TreeWAS – Variant ID: rs5004277

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.000	1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.000	1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.000	1.000
E03.9 Hypothyroidism, unspecified	1.000	0.000	0.000
E05.9 Thyrotoxicosis, unspecified	1.000	0.000	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.000	0.000	1.000
M06.9 Rheumatoid arthritis, unspecified	0.000	0.000	1.000
M20.1 Hallux valgus (acquired)	0.000	0.000	1.000
M35.3 Polymyalgia rheumatica	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	1.000	0.000	0.000
L40 Psoriasis	1.000	0.000	0.000
M06 Other rheumatoid arthritis	0.000	0.000	1.000
E00-E07 Disorders of thyroid gland	1.000	0.000	0.000
M05-M14 Inflammatory polyarthropathies	0.000	0.000	1.000
N00-N08 Glomerular diseases	1.000	0.000	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	1.000	0.000	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	1.000	0.000	0.000
# Top node	1.000	0.000	0.000
E05.0 Thyrotoxicosis with diffuse goitre	1.000	0.000	0.000
M20-M25 Other joint disorders	0.000	0.000	1.000
L40.9 Psoriasis, unspecified	1.000	0.000	0.000
E03 Other hypothyroidism	1.000	0.000	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.000	1.000
M20 Acquired deformities of fingers and toes	0.000	0.000	1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.000	0.000	1.000
M05 Seropositive rheumatoid arthritis	0.000	0.000	1.000
N18 Chronic renal failure	1.000	0.000	0.000
M35 Other systemic involvement of connective tissue	0.000	0.000	1.000
D80-D89 Certain disorders involving the immune mechanism	1.000	0.000	0.000
L40-L45 Papulosquamous disorders	1.000	0.000	0.000
D86 Sarcoidosis	1.000	0.000	0.000
N04 Nephrotic syndrome	1.000	0.000	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.000	1.000
Chapter XIV Diseases of the genitourinary system	1.000	0.000	0.000
N05 Unspecified nephritic syndrome	0.999	0.001	0.000
N04.9 Unspecified	0.999	0.001	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.999	0.001	0.000
N17-N19 Renal failure	0.999	0.001	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.001	0.999
M06.3 Rheumatoid nodule	0.000	0.001	0.999
M45.X9 Ankylosing spondylitis (Site unspecified)	0.000	0.002	0.998
M06.0 Seronegative rheumatoid arthritis	0.000	0.002	0.998
E20-E35 Disorders of other endocrine glands	0.998	0.002	0.000
J30-J39 Other diseases of upper respiratory tract	0.000	0.002	0.998
M45 Ankylosing spondylitis	0.000	0.002	0.998
N18.9 Chronic renal failure, unspecified	0.998	0.002	0.000
M45-M49 Spondylopathies	0.000	0.003	0.997
D60-D64 Aplastic and other anaemias	0.997	0.003	0.000
Chapter X Diseases of the respiratory system	0.000	0.003	0.997
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.997	0.003	0.000
J32 Chronic sinusitis	0.000	0.004	0.996
M06.34 Rheumatoid nodule (Hand)	0.000	0.004	0.996
J32.9 Chronic sinusitis, unspecified	0.000	0.005	0.995
J47 Bronchiectasis	0.000	0.005	0.995
J80-J84 Other respiratory diseases principally affecting the interstitium	0.000	0.006	0.994
D64 Other anaemias	0.994	0.006	0.000
J40-J47 Chronic lower respiratory diseases	0.000	0.007	0.993
D64.9 Anaemia, unspecified	0.993	0.007	0.000
J80 Adult respiratory distress syndrome	0.000	0.008	0.992
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.000	0.008	0.992
L40.5 Arthropathic psoriasis	0.991	0.009	0.000
D86.0 Sarcoidosis of lung	0.987	0.013	0.000
N05.2 Diffuse membranous glomerulonephritis	0.987	0.013	0.000
N18.4 Chronic kidney disease, stage 4	0.986	0.014	0.000
D86.9 Sarcoidosis, unspecified	0.983	0.017	0.000
N08 Glomerular disorders in diseases classified elsewhere	0.982	0.018	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.019	0.981
E27 Other disorders of adrenal gland	0.976	0.024	0.000
E24 Cushing's syndrome	0.976	0.024	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.972	0.028	0.000
N18.0 End-stage renal disease	0.971	0.029	0.000
Q60-Q64 Congenital malformations of the urinary system	0.969	0.031	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.968	0.032	0.000
J33 Nasal polyp	0.000	0.034	0.966
N08.3 Glomerular disorders in diabetes mellitus	0.962	0.038	0.000
E27.1 Primary adrenocortical insufficiency	0.961	0.039	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.000	0.041	0.959
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.000	0.046	0.954
Q61 Cystic kidney disease	0.954	0.046	0.000
E16 Other disorders of pancreatic internal secretion	0.952	0.048	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.948	0.052	0.000
N05.9 Unspecified	0.947	0.053	0.000
Q61.2 Polycystic kidney, adult type	0.944	0.056	0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis	0.000	0.056	0.944
M20.5 Other deformities of toe(s) (acquired)	0.000	0.057	0.943
L43 Lichen planus	0.942	0.058	0.000
D86.3 Sarcoidosis of skin	0.939	0.061	0.000
J35 Chronic diseases of tonsils and adenoids	0.000	0.061	0.939
L10-L14 Bullous disorders	0.937	0.063	0.000
M20.3 Other deformity of hallux (acquired)	0.000	0.063	0.937
J38 Diseases of vocal cords and larynx, not elsewhere classified	0.000	0.065	0.935
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.066	0.934
N05.5 Diffuse mesangiocapillary glomerulonephritis	0.932	0.068	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.070	0.930
Q38-Q45 Other congenital malformations of the digestive system	0.929	0.071	0.000
L50-L54 Urticaria and erythema	0.928	0.072	0.000
Q50-Q56 Congenital malformations of genital organs	0.927	0.073	0.000
M60-M63 Disorders of muscles	0.000	0.084	0.916
E24.0 Pituitary-dependent Cushing's disease	0.913	0.087	0.000
J38.4 Oedema of larynx	0.000	0.088	0.912
L43.9 Lichen planus, unspecified	0.911	0.089	0.000
N18.5 Chronic kidney disease, stage 5	0.910	0.090	0.000
M35.1 Other overlap syndromes	0.000	0.098	0.902
E16.2 Hypoglycaemia, unspecified	0.900	0.100	0.000
Q80-Q89 Other congenital malformations	0.899	0.101	0.000
L13 Other bullous disorders	0.894	0.106	0.000
J33.9 Nasal polyp, unspecified	0.000	0.108	0.892
M65-M68 Disorders of synovium and tendon	0.000	0.111	0.889
J35.8 Other chronic diseases of tonsils and adenoids	0.000	0.114	0.886
E21.0 Primary hyperparathyroidism	0.886	0.114	0.000
Q61.3 Polycystic kidney, unspecified	0.877	0.123	0.000
D63.0 Anaemia in neoplastic disease	0.877	0.123	0.000
N18.2 Chronic kidney disease, stage 2	0.877	0.123	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.000	0.123	0.877
L40.0 Psoriasis vulgaris	0.876	0.124	0.000
N25-N29 Other disorders of kidney and ureter	0.872	0.128	0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.000	0.129	0.871
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.870	0.130	0.000
M62 Other disorders of muscle	0.000	0.131	0.869
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.869	0.131	0.000
G35 Multiple sclerosis	0.000	0.133	0.867
D80 Immunodeficiency with predominantly antibody defects	0.865	0.135	0.000
N05.1 Focal and segmental glomerular lesions	0.864	0.136	0.000
L13.0 Dermatitis herpetiformis	0.864	0.136	0.000
N04.2 Diffuse membranous glomerulonephritis	0.864	0.136	0.000
J33.0 Polyp of nasal cavity	0.000	0.138	0.862
E24.2 Drug-induced Cushing's syndrome	0.861	0.139	0.000
J40 Bronchitis, not specified as acute or chronic	0.000	0.140	0.860
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.143	0.857
L53 Other erythematous conditions	0.857	0.143	0.000
J31.0 Chronic rhinitis	0.000	0.147	0.853
D86.8 Sarcoidosis of other and combined sites	0.853	0.147	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.850	0.150	0.000
M62.8 Other specified disorders of muscle	0.000	0.152	0.848
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.846	0.154	0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.000	0.156	0.844
M65 Synovitis and tenosynovitis	0.000	0.157	0.843
J20-J22 Other acute lower respiratory infections	0.000	0.158	0.842
M06.37 Rheumatoid nodule (Ankle and foot)	0.000	0.158	0.842
N04.1 Focal and segmental glomerular lesions	0.842	0.158	0.000
L52 Erythema nodosum	0.842	0.158	0.000
M31 Other necrotising vasculopathies	0.000	0.161	0.839
E27.3 Drug-induced adrenocortical insufficiency	0.839	0.161	0.000
E10-E14 Diabetes mellitus	0.838	0.162	0.000
E03.8 Other specified hypothyroidism	0.836	0.164	0.000
D69 Purpura and other haemorrhagic conditions	0.834	0.166	0.000
M65.9 Synovitis and tenosynovitis, unspecified	0.000	0.167	0.833
M34 Systemic sclerosis	0.000	0.168	0.832
E21.3 Hyperparathyroidism, unspecified	0.831	0.169	0.000
J82 Pulmonary eosinophilia, not elsewhere classified	0.000	0.169	0.831
L40.1 Generalised pustular psoriasis	0.828	0.172	0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.000	0.174	0.826
M06.32 Rheumatoid nodule (Upper arm)	0.000	0.175	0.824
J33.1 Polypoid sinus degeneration	0.000	0.177	0.823
L44 Other papulosquamous disorders	0.822	0.177	0.000
J31.2 Chronic pharyngitis	0.000	0.178	0.822
Q52 Other congenital malformations of female genitalia	0.822	0.178	0.000
M62.89 Other specified disorders of muscle (Site unspecified)	0.000	0.179	0.821
J42 Unspecified chronic bronchitis	0.000	0.179	0.821
J35.0 Chronic tonsillitis	0.000	0.180	0.820
Q00-Q07 Congenital malformations of the nervous system	0.819	0.181	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.817	0.183	0.000
M35.8 Other specified systemic involvement of connective tissue	0.000	0.185	0.815
Q54 Hypospadias	0.814	0.186	0.000
E24.9 Cushing's syndrome, unspecified	0.814	0.186	0.000
K51.9 Ulcerative colitis, unspecified	0.000	0.187	0.813
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.000	0.189	0.811
E16.1 Other hypoglycaemia	0.810	0.189	0.000
L53.9 Erythematous condition, unspecified	0.810	0.190	0.000
M12 Other specific arthropathies	0.000	0.191	0.809
E16.0 Drug-induced hypoglycaemia without coma	0.807	0.192	0.000
E27.2 Addisonian crisis	0.804	0.196	0.000
N25 Disorders resulting from impaired renal tubular function	0.804	0.196	0.000
J32.2 Chronic ethmoidal sinusitis	0.000	0.197	0.803
Q85 Phakomatoses, not elsewhere classified	0.800	0.200	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.800	0.200	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.000	0.200	0.800
J38.6 Stenosis of larynx	0.000	0.202	0.798
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)	0.000	0.202	0.798
M00-M03 Infectious arthropathies	0.000	0.203	0.797
E14 Unspecified diabetes mellitus	0.796	0.204	0.000
D86.1 Sarcoidosis of lymph nodes	0.794	0.206	0.000
Q44.6 Cystic disease of liver	0.791	0.209	0.000
L40.3 Pustulosis palmaris et plantaris	0.791	0.209	0.000
C20 Malignant neoplasm of rectum	0.788	0.212	0.000
L40.4 Guttate psoriasis	0.785	0.215	0.000
M30 Polyarteritis nodosa and related conditions	0.000	0.216	0.784
J32.1 Chronic frontal sinusitis	0.000	0.217	0.783
D69.6 Thrombocytopenia, unspecified	0.781	0.219	0.000
N08.5 Glomerular disorders in systemic connective tissue disorders	0.773	0.227	0.000
M20.6 Acquired deformity of toe(s), unspecified	0.000	0.228	0.772
J38.5 Laryngeal spasm	0.000	0.229	0.771
J38.7 Other diseases of larynx	0.000	0.229	0.771
N04.8 Other	0.770	0.230	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.769	0.231	0.000
M35.2 Behcet's disease	0.000	0.232	0.768
E31 Polyglandular dysfunction	0.767	0.233	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.000	0.234	0.766
M45.X2 Ankylosing spondylitis (Cervical region)	0.000	0.234	0.765
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.765	0.235	0.000
C15-C26 Malignant neoplasms of digestive organs	0.765	0.235	0.000
M46 Other inflammatory spondylopathies	0.000	0.238	0.762
M05.8 Other seropositive rheumatoid arthritis	0.000	0.240	0.760
D83 Common variable immunodeficiency	0.759	0.241	0.000
D82 Immunodeficiency associated with other major defects	0.756	0.244	0.000
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)	0.000	0.245	0.755
Chapter XV Pregnancy, childbirth and the puerperium	0.755	0.245	0.000
D55-D59 Haemolytic anaemias	0.753	0.247	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.750	0.250	0.000
M31.6 Other giant cell arteritis	0.000	0.251	0.749
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases	0.748	0.252	0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)	0.000	0.254	0.746
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.745	0.255	0.000
M06.30 Rheumatoid nodule (Multiple sites)	0.000	0.255	0.745
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.741	0.259	0.000
K51 Ulcerative colitis	0.000	0.261	0.739
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.000	0.261	0.739
E25 Adrenogenital disorders	0.735	0.265	0.000
N05.8 Other	0.733	0.267	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.732	0.268	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.731	0.269	0.000
M62.80 Other specified disorders of muscle (Multiple sites)	0.000	0.269	0.731
M06.8 Other specified rheumatoid arthritis	0.000	0.269	0.731
N04.0 Minor glomerular abnormality	0.730	0.270	0.000
E21.4 Other specified disorders of parathyroid gland	0.730	0.270	0.000
E14.8 With unspecified complications	0.725	0.275	0.000
Q38.1 Ankyloglossia	0.725	0.275	0.000
Chapter II Neoplasms	0.724	0.276	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.721	0.279	0.000
Q52.5 Fusion of labia	0.720	0.279	0.000
L10 Pemphigus	0.720	0.280	0.000
E40-E46 Malnutrition	0.720	0.280	0.000
J32.0 Chronic maxillary sinusitis	0.000	0.281	0.719
E13 Other specified diabetes mellitus	0.718	0.282	0.000
D69.9 Haemorrhagic condition, unspecified	0.718	0.282	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.000	0.283	0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.283	0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.000	0.283	0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.283	0.717
E05.5 Thyroid crisis or storm	0.717	0.283	0.000
E05.4 Thyrotoxicosis factitia	0.717	0.283	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.717	0.283	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.717	0.283	0.000
L40.2 Acrodermatitis continua	0.717	0.283	0.000
M06.2 Rheumatoid bursitis	0.000	0.283	0.717
M06.1 Adult-onset Still's disease	0.000	0.283	0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.717	0.283	0.000
E00 Congenital iodine-deficiency syndrome	0.717	0.283	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.000	0.283	0.717
N07 Hereditary nephropathy, not elsewhere classified	0.717	0.283	0.000
N06 Isolated proteinuria with specified morphological lesion	0.717	0.283	0.000
N01 Rapidly progressive nephritic syndrome	0.717	0.283	0.000
E03.5 Myxoedema coma	0.717	0.283	0.000
E03.4 Atrophy of thyroid (acquired)	0.717	0.283	0.000
E03.3 Postinfectious hypothyroidism	0.717	0.283	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.000	0.283	0.717
M05.1 Rheumatoid lung disease	0.000	0.283	0.717
M05.0 Felty's syndrome	0.000	0.283	0.717
M35.9 Systemic involvement of connective tissue, unspecified	0.000	0.283	0.717
M35.6 Relapsing panniculitis [Weber-Christian]	0.000	0.283	0.717
M35.5 Multifocal fibrosclerosis	0.000	0.283	0.717
M35.4 Diffuse (eosinophilic) fasciitis	0.000	0.283	0.717
D81 Combined immunodeficiencies	0.717	0.283	0.000
L41 Parapsoriasis	0.717	0.283	0.000
L45 Papulosquamous disorders in diseases classified elsewhere	0.717	0.283	0.000
N04.7 Diffuse crescentic glomerulonephritis	0.717	0.283	0.000
N04.6 Dense deposit disease	0.717	0.283	0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis	0.717	0.283	0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis	0.717	0.283	0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis	0.717	0.283	0.000
N05.6 Dense deposit disease	0.716	0.283	0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis	0.716	0.283	0.000
N05.0 Minor glomerular abnormality	0.716	0.283	0.000
Q85.9 Phakomatosis, unspecified	0.716	0.284	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.000	0.284	0.716
M06.38 Rheumatoid nodule (Other)	0.000	0.284	0.716
M06.36 Rheumatoid nodule (Lower leg)	0.000	0.284	0.716
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.000	0.284	0.716
M06.33 Rheumatoid nodule (Forearm)	0.000	0.284	0.716
M06.31 Rheumatoid nodule (Shoulder region)	0.000	0.284	0.716
M06.08 Seronegative rheumatoid arthritis (Other)	0.000	0.284	0.715
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.000	0.284	0.715
M06.04 Seronegative rheumatoid arthritis (Hand)	0.000	0.284	0.715
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.000	0.284	0.715
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.000	0.284	0.715
E35 Disorders of endocrine glands in diseases classified elsewhere	0.715	0.285	0.000
E32 Diseases of thymus	0.715	0.285	0.000
E30 Disorders of puberty, not elsewhere classified	0.715	0.285	0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.000	0.285	0.715
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.000	0.285	0.715
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.000	0.285	0.715
M45.X4 Ankylosing spondylitis (Thoracic region)	0.000	0.285	0.715
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.000	0.285	0.715
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.000	0.285	0.715
M05.2 Rheumatoid vasculitis	0.000	0.285	0.715
Q30-Q34 Congenital malformations of the respiratory system	0.715	0.285	0.000
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)	0.000	0.287	0.713
D64.4 Congenital dyserythropoietic anaemia	0.712	0.287	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.712	0.287	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.712	0.287	0.000
D64.0 Hereditary sideroblastic anaemia	0.712	0.287	0.000
C25 Malignant neoplasm of pancreas	0.710	0.290	0.000
O00-O08 Pregnancy with abortive outcome	0.709	0.291	0.000
L42 Pityriasis rosea	0.709	0.291	0.000
M34.9 Systemic sclerosis, unspecified	0.000	0.291	0.709
D69.4 Other primary thrombocytopenia	0.708	0.292	0.000
J32.3 Chronic sphenoidal sinusitis	0.000	0.292	0.708
J35.2 Hypertrophy of adenoids	0.000	0.292	0.708
L11 Other acantholytic disorders	0.707	0.293	0.000
Q44.5 Other congenital malformations of bile ducts	0.707	0.293	0.000
K51.4 Pseudopolyposis of colon	0.000	0.296	0.704
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.704	0.296	0.000
N08.8 Glomerular disorders in other diseases classified elsewhere	0.704	0.296	0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism	0.704	0.296	0.000
N08.1 Glomerular disorders in neoplastic diseases	0.704	0.296	0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere	0.704	0.296	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.704	0.296	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.000	0.297	0.703
C50-C50 Malignant neoplasm of breast	0.703	0.297	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.000	0.298	0.702
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments	0.702	0.298	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.702	0.298	0.000
M62.0 Diastasis of muscle	0.000	0.300	0.700
M06.4 Inflammatory polyarthropathy	0.000	0.300	0.700
E27.5 Adrenomedullary hyperfunction	0.700	0.300	0.000
E27.0 Other adrenocortical overactivity	0.700	0.300	0.000
E24.8 Other Cushing's syndrome	0.700	0.300	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.700	0.300	0.000
E24.3 Ectopic ACTH syndrome	0.700	0.300	0.000
E24.1 Nelson's syndrome	0.700	0.300	0.000
E14.3 With ophthalmic complications	0.698	0.302	0.000
E15 Nondiabetic hypoglycaemic coma	0.697	0.303	0.000
N18.3 Chronic kidney disease, stage 3	0.696	0.304	0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.696	0.304	0.000
K51.3 Ulcerative (chronic) rectosigmoiditis	0.000	0.304	0.696
L44.0 Pityriasis rubra pilaris	0.695	0.305	0.000
M45.X6 Ankylosing spondylitis (Lumbar region)	0.000	0.306	0.694
J41 Simple and mucopurulent chronic bronchitis	0.000	0.306	0.694
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.694	0.306	0.000
O24 Diabetes mellitus in pregnancy	0.694	0.306	0.000
D69.2 Other nonthrombocytopenic purpura	0.694	0.306	0.000
Q51 Congenital malformations of uterus and cervix	0.693	0.307	0.000
C25.9 Pancreas, unspecified	0.692	0.308	0.000
J31.1 Chronic nasopharyngitis	0.000	0.308	0.692
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.691	0.309	0.000
O00 Ectopic pregnancy	0.691	0.309	0.000
Q38.7 Pharyngeal pouch	0.688	0.312	0.000
C50 Malignant neoplasm of breast	0.688	0.312	0.000
Q89 Other congenital malformations, not elsewhere classified	0.688	0.312	0.000
L53.0 Toxic erythema	0.686	0.314	0.000
D64.3 Other sideroblastic anaemias	0.686	0.314	0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis	0.685	0.315	0.000
N00 Acute nephritic syndrome	0.685	0.315	0.000
Q61.8 Other cystic kidney diseases	0.684	0.316	0.000
Q61.1 Polycystic kidney, infantile type	0.684	0.316	0.000
Q54.1 Hypospadias, penile	0.683	0.317	0.000
M62.88 Other specified disorders of muscle (Other)	0.000	0.318	0.682
E16.9 Disorder of pancreatic internal secretion, unspecified	0.682	0.318	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.682	0.318	0.000
E16.4 Abnormal secretion of gastrin	0.682	0.318	0.000
E16.3 Increased secretion of glucagon	0.682	0.318	0.000
O00.1 Tubal pregnancy	0.681	0.319	0.000
J20 Acute bronchitis	0.000	0.320	0.680
D63.1 Anaemia in other chronic diseases classified elsewhere	0.680	0.320	0.000
J22 Unspecified acute lower respiratory infection	0.000	0.320	0.680
Q07 Other congenital malformations of nervous system	0.678	0.322	0.000
N28 Other disorders of kidney and ureter, not elsewhere classified	0.676	0.324	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.000	0.324	0.676
L43.3 Subacute (active) lichen planus	0.675	0.325	0.000
L43.2 Lichenoid drug reaction	0.675	0.325	0.000
L43.1 Bullous lichen planus	0.675	0.325	0.000
J32.4 Chronic pansinusitis	0.000	0.325	0.675
E20 Hypoparathyroidism	0.675	0.325	0.000
L43.0 Hypertrophic lichen planus	0.675	0.325	0.000
D84 Other immunodeficiencies	0.675	0.325	0.000
J35.9 Chronic disease of tonsils and adenoids, unspecified	0.000	0.325	0.675
J35.3 Hypertrophy of tonsils with hypertrophy of adenoids	0.000	0.327	0.673
Q44.7 Other congenital malformations of liver	0.673	0.327	0.000
L14 Bullous disorders in diseases classified elsewhere	0.672	0.328	0.000
E22 Hyperfunction of pituitary gland	0.672	0.328	0.000
Q87.4 Marfan's syndrome	0.671	0.328	0.000
C23 Malignant neoplasm of gallbladder	0.671	0.329	0.000
N25.8 Other disorders resulting from impaired renal tubular function	0.670	0.330	0.000
Q54.9 Hypospadias, unspecified	0.669	0.331	0.000
D69.8 Other specified haemorrhagic conditions	0.668	0.332	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.667	0.333	0.000
Q38.6 Other congenital malformations of mouth	0.667	0.333	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.667	0.333	0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.000	0.333	0.667
C21 Malignant neoplasm of anus and anal canal	0.667	0.333	0.000
M62.83 Other specified disorders of muscle (Forearm)	0.000	0.333	0.667
M62.9 Disorder of muscle, unspecified	0.000	0.333	0.667
Q42 Congenital absence, atresia and stenosis of large intestine	0.666	0.334	0.000
Q41 Congenital absence, atresia and stenosis of small intestine	0.666	0.334	0.000
Q85.0 Neurofibromatosis (nonmalignant)	0.666	0.334	0.000
L54 Erythema in diseases classified elsewhere	0.665	0.335	0.000
Q56 Indeterminate sex and pseudohermaphroditism	0.665	0.335	0.000
C50.1 Central portion of breast	0.664	0.336	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.663	0.337	0.000
M49 Spondylopathies in diseases classified elsewhere	0.000	0.339	0.661
M66 Spontaneous rupture of synovium and tendon	0.000	0.340	0.660
C32 Malignant neoplasm of larynx	0.660	0.340	0.000
N25.0 Renal osteodystrophy	0.660	0.340	0.000
O24.4 Diabetes mellitus arising in pregnancy	0.659	0.341	0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.000	0.342	0.658
M63 Disorders of muscle in diseases classified elsewhere	0.000	0.343	0.657
M61 Calcification and ossification of muscle	0.000	0.343	0.657
N25.1 Nephrogenic diabetes insipidus	0.655	0.345	0.000
N02 Recurrent and persistent haematuria	0.655	0.345	0.000
E28 Ovarian dysfunction	0.654	0.346	0.000
E21.2 Other hyperparathyroidism	0.653	0.347	0.000
E03.1 Congenital hypothyroidism without goitre	0.652	0.348	0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter	0.652	0.348	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.652	0.348	0.000
M34.8 Other forms of systemic sclerosis	0.000	0.350	0.650
D80.1 Nonfamilial hypogammaglobulinaemia	0.649	0.351	0.000
Q76 Congenital malformations of spine and bony thorax	0.648	0.352	0.000
M08 Juvenile arthritis	0.000	0.352	0.648
E14.4 With neurological complications	0.648	0.352	0.000
Q52.1 Doubling of vagina	0.647	0.353	0.000
Q64 Other congenital malformations of urinary system	0.646	0.354	0.000
M12.3 Palindromic rheumatism	0.000	0.354	0.645
C15 Malignant neoplasm of oesophagus	0.645	0.355	0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.644	0.356	0.000
Q84 Other congenital malformations of integument	0.644	0.356	0.000
Q81 Epidermolysis bullosa	0.644	0.356	0.000
Q80 Congenital ichthyosis	0.644	0.356	0.000
C50.5 Lower-outer quadrant of breast	0.642	0.358	0.000
Q43 Other congenital malformations of intestine	0.642	0.358	0.000
M00 Pyogenic arthritis	0.000	0.358	0.641
N17 Acute renal failure	0.641	0.358	0.000
L13.9 Bullous disorder, unspecified	0.641	0.359	0.000
L13.8 Other specified bullous disorders	0.641	0.359	0.000
L13.1 Subcorneal pustular dermatitis	0.641	0.359	0.000
M62.82 Other specified disorders of muscle (Upper arm)	0.000	0.359	0.641
E14.2 Withrenal complications	0.641	0.359	0.000
N29 Other disorders of kidney and ureter in diseases classified elsewhere	0.640	0.360	0.000
M91-M94 Chondropathies	0.000	0.360	0.640
M31.7 Microscopic polyangiitis	0.000	0.360	0.640
Q35-Q37 Cleft lip and cleft palate	0.638	0.362	0.000
O21 Excessive vomiting in pregnancy	0.638	0.362	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.000	0.363	0.637
E13.9 Without complications	0.636	0.364	0.000
Q38.8 Other congenital malformations of pharynx	0.635	0.365	0.000
M65.1 Other infective (teno)synovitis	0.000	0.366	0.634
Q82 Other congenital malformations of skin	0.632	0.368	0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.632	0.368	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.000	0.369	0.630
N18.8 Other chronic renal failure	0.630	0.370	0.000
D66 Hereditary factor VIII deficiency	0.629	0.371	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.000	0.371	0.629
C15.4 Middle third of oesophagus	0.629	0.371	0.000
Q60.0 Renal agenesis, unilateral	0.628	0.372	0.000
O85-O92 Complications predominantly related to the puerperium	0.628	0.372	0.000
L40.8 Other psoriasis	0.627	0.373	0.000
M34.1 CR(E)ST syndrome	0.000	0.373	0.627
E14.1 With ketoacidosis	0.626	0.374	0.000
E05.8 Other thyrotoxicosis	0.626	0.374	0.000
E34 Other endocrine disorders	0.625	0.375	0.000
M46.9 Inflammatory spondylopathy, unspecified	0.000	0.375	0.625
Q04 Other congenital malformations of brain	0.624	0.376	0.000
Q44.4 Choledochal cyst	0.624	0.376	0.000
Q44.3 Congenital stenosis and stricture of bile ducts	0.624	0.376	0.000
Q44.2 Atresia of bile ducts	0.624	0.376	0.000
Q44.1 Other congenital malformations of gallbladder	0.624	0.376	0.000
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder	0.624	0.376	0.000
M62.4 Contracture of muscle	0.000	0.377	0.623
M62.3 Immobility syndrome (paraplegic)	0.000	0.377	0.623
M62.2 Ischaemic infarction of muscle	0.000	0.377	0.623
C38 Malignant neoplasm of heart, mediastinum and pleura	0.623	0.377	0.000
Q40 Other congenital malformations of upper alimentary tract	0.623	0.377	0.000
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)	0.000	0.378	0.622
J95-J99 Other diseases of the respiratory system	0.000	0.379	0.621
E14.5 With peripheral circulatory complications	0.621	0.379	0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.000	0.379	0.621
D80.8 Other immunodeficiencies with predominantly antibody defects	0.620	0.380	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.620	0.380	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.620	0.380	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.620	0.380	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.620	0.380	0.000
M46.1 Sacro-iliitis, not elsewhere classified	0.000	0.381	0.619
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.619	0.381	0.000
N18.1 Chronic kidney disease, stage 1	0.618	0.382	0.000
Q63 Other congenital malformations of kidney	0.618	0.382	0.000
O28 Abnormal findings on antenatal screening of mother	0.617	0.383	0.000
M12.2 Villonodular synovitis (pigmented)	0.000	0.383	0.617
D70 Agranulocytosis	0.617	0.383	0.000
Q53 Undescended testicle	0.616	0.384	0.000
M31.8 Other specified necrotising vasculopathies	0.000	0.384	0.616
D59 Acquired haemolytic anaemia	0.615	0.385	0.000
Q61.4 Renal dysplasia	0.614	0.386	0.000
L53.3 Other chronic figurate erythema	0.614	0.386	0.000
L53.2 Erythema marginatum	0.614	0.386	0.000
L53.1 Erythema annulare centrifugum	0.614	0.386	0.000
M65.3 Trigger finger	0.000	0.386	0.614
Q55 Other congenital malformations of male genital organs	0.613	0.386	0.000
M62.84 Other specified disorders of muscle (Hand)	0.000	0.387	0.613
C32.9 Larynx, unspecified	0.613	0.387	0.000
Chapter XXII Codes for special purposes	0.613	0.387	0.000
N02.2 Diffuse membranous glomerulonephritis	0.611	0.389	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations