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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs5006725
log Bayes Factor = 104.879
Chromosome 6   position 31,337,872  (GRCh37) Explore rs5006725 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
K51.9 Ulcerative colitis, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
K51 Ulcerative colitis
1.000 0.000 0.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
M45 Ankylosing spondylitis
0.999 0.001 0.000
E83.1 Disorders of iron metabolism
0.999 0.001 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.999 0.001 0.000
E10.1 With ketoacidosis
0.000 0.002 0.998
E14.9 Without complications
0.000 0.002 0.998
K51.4 Pseudopolyposis of colon
0.994 0.006 0.000
G35 Multiple sclerosis
0.993 0.007 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.007 0.993
K51.2 Ulcerative (chronic) proctitis
0.989 0.011 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.018 0.982
M06.9 Rheumatoid arthritis, unspecified
0.000 0.026 0.974
E10.4 With neurological complications
0.000 0.030 0.970
E00-E07 Disorders of thyroid gland
0.000 0.034 0.966
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.034 0.966
K51.3 Ulcerative (chronic) rectosigmoiditis
0.964 0.036 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.039 0.961
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.040 0.960
E27 Other disorders of adrenal gland
0.000 0.046 0.954
E11.1 With ketoacidosis
0.000 0.052 0.948
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.059 0.941
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.068 0.932
E11.3 With ophthalmic complications
0.000 0.068 0.932
E10.0 With coma
0.000 0.073 0.927
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.081 0.919
E11.0 With coma
0.000 0.087 0.913
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.088 0.912
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.095 0.905
E10.8 With unspecified complications
0.000 0.110 0.889
E27.1 Primary adrenocortical insufficiency
0.000 0.112 0.888
E14.1 With ketoacidosis
0.000 0.113 0.887
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.125 0.875
E10.6 With other specified complications
0.000 0.139 0.861
K51.5 Mucosal proctocolitis
0.858 0.142 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.145 0.855
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.150 0.850
K51.8 Other ulcerative colitis
0.845 0.155 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.163 0.837
M45.X2 Ankylosing spondylitis (Cervical region)
0.835 0.165 0.000
E23 Hypofunction and other disorders of pituitary gland
0.000 0.166 0.834
E22 Hyperfunction of pituitary gland
0.000 0.174 0.826
E11.5 With peripheral circulatory complications
0.000 0.184 0.816
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.810 0.190 0.000
E24 Cushing's syndrome
0.000 0.198 0.802
E14.6 With other specified complications
0.000 0.203 0.797
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.204 0.796
E10.2 With renal complications
0.000 0.210 0.790
M45.X6 Ankylosing spondylitis (Lumbar region)
0.784 0.216 0.000
E16.1 Other hypoglycaemia
0.000 0.222 0.778
E14.3 With ophthalmic complications
0.000 0.227 0.773
E13 Other specified diabetes mellitus
0.000 0.230 0.770
E14.2 Withrenal complications
0.000 0.232 0.768
G35-G37 Demyelinating diseases of the central nervous system
0.767 0.233 0.000
E05.8 Other thyrotoxicosis
0.000 0.240 0.760
E23.2 Diabetes insipidus
0.000 0.241 0.759
E11.9 Without complications
0.000 0.242 0.758
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.248 0.752
E10.5 With peripheral circulatory complications
0.000 0.265 0.735
E40-E46 Malnutrition
0.000 0.271 0.729
E25 Adrenogenital disorders
0.000 0.275 0.725
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.716 0.284 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.716 0.284 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.716 0.284 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.716 0.284 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.716 0.284 0.000
E14.8 With unspecified complications
0.000 0.285 0.715
E11.7 With multiple complications
0.000 0.288 0.712
G37 Other demyelinating diseases of central nervous system
0.711 0.289 0.000
E34 Other endocrine disorders
0.000 0.291 0.709
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.294 0.706
E26 Hyperaldosteronism
0.000 0.295 0.705
E28 Ovarian dysfunction
0.000 0.295 0.704
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.296 0.704
E32 Diseases of thymus
0.000 0.296 0.704
E30 Disorders of puberty, not elsewhere classified
0.000 0.296 0.704
E10.7 With multiple complications
0.000 0.297 0.703
E24.0 Pituitary-dependent Cushing's disease
0.000 0.305 0.695
E07 Other disorders of thyroid
0.000 0.306 0.694
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.307 0.693
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.307 0.692
E00 Congenital iodine-deficiency syndrome
0.000 0.307 0.692
E05.5 Thyroid crisis or storm
0.000 0.307 0.692
E05.4 Thyrotoxicosis factitia
0.000 0.307 0.692
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.307 0.692
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.307 0.692
E14.5 With peripheral circulatory complications
0.000 0.309 0.691
E27.5 Adrenomedullary hyperfunction
0.000 0.316 0.684
E27.0 Other adrenocortical overactivity
0.000 0.316 0.684
E31 Polyglandular dysfunction
0.000 0.318 0.682
K51.0 Ulcerative (chronic) enterocolitis
0.681 0.319 0.000
J45 Asthma
0.000 0.326 0.674
E29 Testicular dysfunction
0.000 0.330 0.670
G37.9 Demyelinating disease of central nervous system, unspecified
0.666 0.334 0.000
E22.0 Acromegaly and pituitary gigantism
0.000 0.338 0.662
E20 Hypoparathyroidism
0.000 0.339 0.661
E23.7 Disorder of pituitary gland, unspecified
0.000 0.347 0.653
M06 Other rheumatoid arthritis
0.002 0.348 0.650
E14.4 With neurological complications
0.000 0.360 0.640
E11.6 With other specified complications
0.000 0.363 0.637
E27.8 Other specified disorders of adrenal gland
0.000 0.365 0.635
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.366 0.634
M06.3 Rheumatoid nodule
0.001 0.372 0.627
E11.8 With unspecified complications
0.000 0.375 0.624
E13.9 Without complications
0.000 0.380 0.620
K51.1 Ulcerative (chronic) ileocolitis
0.619 0.381 0.000
K90 Intestinal malabsorption
0.000 0.385 0.615
E24.2 Drug-induced Cushing's syndrome
0.000 0.388 0.612
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.402 0.598
E23.1 Drug-induced hypopituitarism
0.000 0.402 0.598
E22.8 Other hyperfunction of pituitary gland
0.000 0.408 0.592
G36 Other acute disseminated demyelination
0.591 0.409 0.000
E28.2 Polycystic ovarian syndrome
0.000 0.415 0.585
E11.4 With neurological complications
0.000 0.417 0.583
M06.34 Rheumatoid nodule (Hand)
0.000 0.420 0.580
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.420 0.580
E22.1 Hyperprolactinaemia
0.000 0.420 0.580
E23.6 Other disorders of pituitary gland
0.000 0.424 0.576
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.425 0.575
E24.3 Ectopic ACTH syndrome
0.000 0.425 0.575
E24.1 Nelson's syndrome
0.000 0.425 0.575
E11.2 With renal complications
0.000 0.426 0.574
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.436 0.564
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.438 0.562
E07.8 Other specified disorders of thyroid
0.000 0.439 0.561
J45.1 Nonallergic asthma
0.000 0.445 0.555
E13.8 With unspecified complications
0.000 0.448 0.552
E13.7 With multiple complications
0.000 0.448 0.552
E13.6 With other specified complications
0.000 0.448 0.552
E13.5 With peripheral circulatory complications
0.000 0.448 0.552
E13.4 With neurological complications
0.000 0.448 0.552
E13.2 With renal complications
0.000 0.448 0.552
E13.1 With ketoacidosis
0.000 0.448 0.552
E13.0 With coma
0.000 0.448 0.552
G37.8 Other specified demyelinating diseases of central nervous system
0.546 0.454 0.000
E26.9 Hyperaldosteronism, unspecified
0.000 0.454 0.545
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.455 0.544
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.459 0.541
E34.9 Endocrine disorder, unspecified
0.000 0.462 0.538
E46 Unspecified protein-energy malnutrition
0.000 0.466 0.534
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.467 0.533
J45.8 Mixed asthma
0.000 0.468 0.532
E13.3 With ophthalmic complications
0.000 0.468 0.532
E24.9 Cushing's syndrome, unspecified
0.000 0.468 0.532
J45.0 Predominantly allergic asthma
0.000 0.468 0.532
E24.8 Other Cushing's syndrome
0.000 0.472 0.528
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.477 0.522
E45 Retarded development following protein-energy malnutrition
0.000 0.477 0.522
E43 Unspecified severe protein-energy malnutrition
0.000 0.477 0.522
E42 Marasmic kwashiorkor
0.000 0.477 0.522
E41 Nutritional marasmus
0.000 0.477 0.522
E40 Kwashiorkor
0.000 0.477 0.522
E25.9 Adrenogenital disorder, unspecified
0.000 0.480 0.520
E25.8 Other adrenogenital disorders
0.000 0.480 0.520
E34.0 Carcinoid syndrome
0.000 0.481 0.519
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
K90.9 Intestinal malabsorption, unspecified
0.000 0.488 0.511
G37.5 Concentric sclerosis [Balo]
0.510 0.490 0.000
G37.4 Subacute necrotising myelitis
0.510 0.490 0.000
G37.2 Central pontine myelinolysis
0.510 0.490 0.000
G37.1 Central demyelination of corpus callosum
0.510 0.490 0.000
G37.0 Diffuse sclerosis
0.510 0.490 0.000
E34.5 Androgen resistance syndrome
0.000 0.491 0.509
E34.4 Constitutional tall stature
0.000 0.491 0.509
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.491 0.509
E34.1 Other hypersecretion of intestinal hormones
0.000 0.491 0.509
E26.8 Other hyperaldosteronism
0.000 0.494 0.506
E26.1 Secondary hyperaldosteronism
0.000 0.494 0.506
E28.9 Ovarian dysfunction, unspecified
0.000 0.495 0.505
E28.8 Other ovarian dysfunction
0.000 0.495 0.505
E28.1 Androgen excess
0.000 0.495 0.505
E28.0 Oestrogen excess
0.000 0.495 0.505
E30.9 Disorder of puberty, unspecified
0.000 0.495 0.505
E30.8 Other disorders of puberty
0.000 0.495 0.505
E30.1 Precocious puberty
0.000 0.495 0.505
E30.0 Delayed puberty
0.000 0.495 0.505
E32.9 Disease of thymus, unspecified
0.000 0.495 0.505
E32.8 Other diseases of thymus
0.000 0.495 0.505
E32.1 Abscess of thymus
0.000 0.495 0.505
E32.0 Persistent hyperplasia of thymus
0.000 0.495 0.505
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.495 0.505
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.495 0.505
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.495 0.505
K90.8 Other intestinal malabsorption
0.000 0.502 0.498
E07.1 Dyshormogenetic goitre
0.000 0.502 0.497
E07.0 Hypersecretion of calcitonin
0.000 0.502 0.497
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.503 0.496
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.503 0.496
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.503 0.496
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.503 0.496
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.503 0.496
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.503 0.496
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.503 0.496
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.503 0.496
E27.2 Addisonian crisis
0.000 0.504 0.495
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.494 0.506 0.000
H20.9 Iridocyclitis, unspecified
0.490 0.510 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.510 0.490
E34.3 Short stature, not elsewhere classified
0.000 0.510 0.490
E31.9 Polyglandular dysfunction, unspecified
0.000 0.511 0.489
E31.8 Other polyglandular dysfunction
0.000 0.511 0.489
E31.1 Polyglandular hyperfunction
0.000 0.511 0.489
E34.8 Other specified endocrine disorders
0.000 0.511 0.489
E29.9 Testicular dysfunction, unspecified
0.000 0.520 0.480
E29.8 Other testicular dysfunction
0.000 0.520 0.480
E29.0 Testicular hyperfunction
0.000 0.520 0.480
E20.8 Other hypoparathyroidism
0.000 0.526 0.474
E20.1 Pseudohypoparathyroidism
0.000 0.526 0.474
E20.0 Idiopathic hypoparathyroidism
0.000 0.526 0.474
M06.8 Other specified rheumatoid arthritis
0.002 0.526 0.472
M06.2 Rheumatoid bursitis
0.002 0.532 0.466
M06.1 Adult-onset Still's disease
0.002 0.532 0.466
E31.0 Autoimmune polyglandular failure
0.000 0.532 0.467
G36.0 Neuromyelitis optica [Devic]
0.464 0.536 0.000
E26.0 Primary hyperaldosteronism
0.000 0.542 0.458
M06.30 Rheumatoid nodule (Multiple sites)
0.001 0.542 0.458
M06.4 Inflammatory polyarthropathy
0.001 0.545 0.454
E03 Other hypothyroidism
0.000 0.548 0.452
M06.39 Rheumatoid nodule (Site unspecified)
0.001 0.550 0.450
M06.38 Rheumatoid nodule (Other)
0.001 0.550 0.450
M06.36 Rheumatoid nodule (Lower leg)
0.001 0.550 0.450
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.001 0.550 0.450
M06.33 Rheumatoid nodule (Forearm)
0.001 0.550 0.450
M06.31 Rheumatoid nodule (Shoulder region)
0.001 0.550 0.450
E29.1 Testicular hypofunction
0.000 0.554 0.446
H20 Iridocyclitis
0.445 0.555 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.556 0.444
K90.3 Pancreatic steatorrhoea
0.000 0.559 0.441
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.559 0.441
K90.1 Tropical sprue
0.000 0.559 0.441
E23.0 Hypopituitarism
0.000 0.564 0.435
E20.9 Hypoparathyroidism, unspecified
0.000 0.569 0.431
G36.9 Acute disseminated demyelination, unspecified
0.423 0.576 0.000
G36.8 Other specified acute disseminated demyelination
0.423 0.576 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.423 0.576 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.577 0.422
E07.9 Disorder of thyroid, unspecified
0.000 0.593 0.407
I10 Essential (primary) hypertension
0.000 0.593 0.407
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.595 0.404
E06 Thyroiditis
0.000 0.607 0.392
H20.0 Acute and subacute iridocyclitis
0.388 0.612 0.000
E44.1 Mild protein-energy malnutrition
0.000 0.625 0.375
E44.0 Moderate protein-energy malnutrition
0.000 0.625 0.375
E28.3 Primary ovarian failure
0.000 0.627 0.373
H20.8 Other iridocyclitis
0.370 0.630 0.000
H20.1 Chronic iridocyclitis
0.369 0.631 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.635 0.365
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.001 0.654 0.344
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.656 0.344
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.001 0.657 0.342
M06.88 Other specified rheumatoid arthritis (Other)
0.001 0.660 0.338
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.001 0.660 0.338
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.001 0.660 0.338
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.001 0.660 0.338
M06.84 Other specified rheumatoid arthritis (Hand)
0.001 0.660 0.338
M06.83 Other specified rheumatoid arthritis (Forearm)
0.001 0.660 0.338
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.001 0.660 0.338
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.001 0.660 0.338
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.001 0.660 0.338
M06.19 Adult-onset Still's disease (Site unspecified)
0.002 0.664 0.334
M06.18 Adult-onset Still's disease (Other)
0.002 0.664 0.334
M06.17 Adult-onset Still's disease (Ankle and foot)
0.002 0.664 0.334
M06.16 Adult-onset Still's disease (Lower leg)
0.002 0.664 0.334
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.002 0.664 0.334
M06.14 Adult-onset Still's disease (Hand)
0.002 0.664 0.334
M06.13 Adult-onset Still's disease (Forearm)
0.002 0.664 0.334
M06.12 Adult-onset Still's disease (Upper arm)
0.002 0.664 0.334
M06.11 Adult-onset Still's disease (Shoulder region)
0.002 0.664 0.334
M06.10 Adult-onset Still's disease (Multiple sites)
0.002 0.664 0.334
M06.29 Rheumatoid bursitis (Site unspecified)
0.002 0.664 0.334
M06.28 Rheumatoid bursitis (Other)
0.002 0.664 0.334
M06.27 Rheumatoid bursitis (Ankle and foot)
0.002 0.664 0.334
M06.26 Rheumatoid bursitis (Lower leg)
0.002 0.664 0.334
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.002 0.664 0.334
M06.24 Rheumatoid bursitis (Hand)
0.002 0.664 0.334
M06.23 Rheumatoid bursitis (Forearm)
0.002 0.664 0.334
M06.22 Rheumatoid bursitis (Upper arm)
0.002 0.664 0.334
M06.21 Rheumatoid bursitis (Shoulder region)
0.002 0.664 0.334
M06.20 Rheumatoid bursitis (Multiple sites)
0.002 0.664 0.334
M06.48 Inflammatory polyarthropathy (Other)
0.001 0.673 0.325
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.001 0.673 0.325
M06.46 Inflammatory polyarthropathy (Lower leg)
0.001 0.673 0.325
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.001 0.673 0.325
M06.44 Inflammatory polyarthropathy (Hand)
0.001 0.673 0.325
M06.43 Inflammatory polyarthropathy (Forearm)
0.001 0.673 0.325
M06.42 Inflammatory polyarthropathy (Upper arm)
0.001 0.673 0.325
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.001 0.673 0.325
E03.5 Myxoedema coma
0.000 0.676 0.324
E03.4 Atrophy of thyroid (acquired)
0.000 0.676 0.324
E03.3 Postinfectious hypothyroidism
0.000 0.676 0.324
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.676 0.324
H20.2 Lens-induced iridocyclitis
0.319 0.681 0.000
E21.4 Other specified disorders of parathyroid gland
0.000 0.682 0.318
E50-E64 Other nutritional deficiencies
0.000 0.688 0.312
E03.1 Congenital hypothyroidism without goitre
0.000 0.688 0.312
E67 Other hyperalimentation
0.000 0.697 0.303
E68 Sequelae of hyperalimentation
0.000 0.697 0.303
E03.8 Other specified hypothyroidism
0.000 0.705 0.295
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.001 0.706 0.293
E65 Localised adiposity
0.000 0.715 0.285
E06.4 Drug-induced thyroiditis
0.000 0.718 0.281
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.718 0.281
E06.0 Acute thyroiditis
0.000 0.718 0.281
E21.2 Other hyperparathyroidism
0.000 0.719 0.280
E06.1 Subacute thyroiditis
0.000 0.721 0.279
E21.3 Hyperparathyroidism, unspecified
0.000 0.731 0.269
E06.5 Other chronic thyroiditis
0.000 0.732 0.267
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.735 0.265
K50-K52 Noninfective enteritis and colitis
0.263 0.736 0.000
E21.0 Primary hyperparathyroidism
0.000 0.745 0.255
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.244 0.756 0.000
E51 Thiamine deficiency
0.000 0.757 0.243
E83 Disorders of mineral metabolism
0.239 0.760 0.002
H21 Other disorders of iris and ciliary body
0.232 0.768 0.000
H21.5 Other adhesions and disruptions of iris and ciliary body
0.229 0.771 0.000
E58 Dietary calcium deficiency
0.000 0.775 0.225
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.776 0.224
E63 Other nutritional deficiencies
0.000 0.776 0.224
E50 Vitamin A deficiency
0.000 0.776 0.224
E60 Dietary zinc deficiency
0.000 0.776 0.224
E59 Dietary selenium deficiency
0.000 0.776 0.224
E54 Ascorbic acid deficiency
0.000 0.776 0.224
E52 Niacin deficiency [pellagra]
0.000 0.776 0.224
E67.8 Other specified hyperalimentation
0.000 0.782 0.217
E67.3 Hypervitaminosis D
0.000 0.782 0.217
E67.2 Megavitamin-B6 syndrome
0.000 0.782 0.217
E67.1 Hypercarotenaemia
0.000 0.782 0.217
E67.0 Hypervitaminosis A
0.000 0.782 0.217
H36.0 Diabetic retinopathy
0.000 0.791 0.209
E56 Other vitamin deficiencies
0.000 0.795 0.205
E06.9 Thyroiditis, unspecified
0.000 0.804 0.195
E51.2 Wernicke's encephalopathy
0.000 0.807 0.193
E06.3 Autoimmune thyroiditis
0.000 0.809 0.190
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.189 0.811 0.000
H21.8 Other specified disorders of iris and ciliary body
0.188 0.812 0.000
E51.9 Thiamine deficiency, unspecified
0.000 0.826 0.174
E51.8 Other manifestations of thiamine deficiency
0.000 0.826 0.174
E51.1 Beriberi
0.000 0.826 0.174
E83.9 Disorder of mineral metabolism, unspecified
0.171 0.827 0.001
E83.8 Other disorders of mineral metabolism
0.171 0.827 0.001
E83.2 Disorders of zinc metabolism
0.171 0.827 0.001
E83.0 Disorders of copper metabolism
0.171 0.827 0.001
E61 Deficiency of other nutrient elements
0.000 0.828 0.172
H21.2 Degeneration of iris and ciliary body
0.170 0.830 0.000
H21.4 Pupillary membranes
0.166 0.833 0.000
H21.3 Cyst of iris, ciliary body and anterior chamber
0.166 0.833 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.165 0.835 0.000
K50 Crohn's disease [regional enteritis]
0.164 0.836 0.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.838 0.162
E83.3 Disorders of phosphorus metabolism
0.161 0.838 0.001
E50.9 Vitamin A deficiency, unspecified
0.000 0.839 0.161
E50.8 Other manifestations of vitamin A deficiency
0.000 0.839 0.161
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.839 0.161
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.839 0.161
E50.5 Vitamin A deficiency with night blindness
0.000 0.839 0.161
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.839 0.161
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.839 0.161
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.839 0.161
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.839 0.161
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.839 0.161
E63.9 Nutritional deficiency, unspecified
0.000 0.839 0.161
E63.8 Other specified nutritional deficiencies
0.000 0.839 0.161
E63.1 Imbalance of constituents of food intake
0.000 0.839 0.161
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.839 0.161
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.839 0.161
E64.8 Sequelae of other nutritional deficiencies
0.000 0.839 0.161
E64.3 Sequelae of rickets
0.000 0.839 0.161
E64.2 Sequelae of vitamin C deficiency
0.000 0.839 0.161
E64.1 Sequelae of vitamin A deficiency
0.000 0.839 0.161
E64.0 Sequelae of protein-energy malnutrition
0.000 0.839 0.161
E83.4 Disorders of magnesium metabolism
0.160 0.840 0.000
H16 Keratitis
0.160 0.840 0.000
E55 Vitamin D deficiency
0.000 0.840 0.160
H17 Corneal scars and opacities
0.156 0.844 0.000
K52 Other non-infective gastro-enteritis and colitis
0.151 0.849 0.000
H22.1 Iridocyclitis in other diseases classified elsewhere
0.149 0.851 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.853 0.147
E56.8 Deficiency of other vitamins
0.000 0.853 0.147
E56.0 Deficiency of vitamin E
0.000 0.853 0.147
H18 Other disorders of cornea
0.147 0.853 0.000
H21.9 Disorder of iris and ciliary body, unspecified
0.144 0.856 0.000
H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
0.143 0.857 0.000
K52.3 Indeterminate colitis
0.142 0.858 0.000
H15 Disorders of sclera
0.141 0.858 0.000
H21.0 Hyphaema
0.139 0.861 0.000
K50.1 Crohn's disease of large intestine
0.138 0.862 0.000
K50.9 Crohn's disease, unspecified
0.136 0.864 0.000
H22.8 Other disorders of iris and ciliary body in diseases classified elsewhere
0.135 0.864 0.000
H22.0 Iridocyclitis in infectious and parasitic diseases classified elsewhere
0.135 0.864 0.000
H30-H36 Disorders of choroid and retina
0.000 0.871 0.129
H16.9 Keratitis, unspecified
0.128 0.872 0.000
H21.1 Other vascular disorders of iris and ciliary body
0.128 0.872 0.000
E56.1 Deficiency of vitamin K
0.000 0.872 0.127
H16.0 Corneal ulcer
0.128 0.872 0.000
K52.1 Toxic gastro-enteritis and colitis
0.126 0.873 0.000
E04 Other non-toxic goitre
0.000 0.875 0.125
E61.9 Deficiency of nutrient element, unspecified
0.000 0.876 0.123
E61.8 Deficiency of other specified nutrient elements
0.000 0.876 0.123
E61.7 Deficiency of multiple nutrient elements
0.000 0.876 0.123
E61.6 Vanadium deficiency
0.000 0.876 0.123
E61.5 Molybdenum deficiency
0.000 0.876 0.123
E61.4 Chromium deficiency
0.000 0.876 0.123
E61.3 Manganese deficiency
0.000 0.876 0.123
E61.0 Copper deficiency
0.000 0.876 0.123
E53 Deficiency of other B group vitamins
0.000 0.878 0.122
E83.5 Disorders of calcium metabolism
0.119 0.881 0.000
H19.8 Other disorders of sclera and cornea in diseases classified elsewhere
0.118 0.881 0.000
H19.0 Scleritis and episcleritis in diseases classified elsewhere
0.118 0.881 0.000
H33 Retinal detachments and breaks
0.000 0.882 0.118
K52.0 Gastro-enteritis and colitis due to radiation
0.117 0.883 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.883 0.116
H18.3 Changes in corneal membranes
0.115 0.885 0.000
H16.8 Other keratitis
0.115 0.885 0.000
H16.4 Corneal neovascularisation
0.115 0.885 0.000
M06.0 Seronegative rheumatoid arthritis
0.003 0.885 0.112
E55.0 Rickets, active
0.000 0.885 0.115
H18.5 Hereditary corneal dystrophies
0.115 0.885 0.000
H18.6 Keratoconus
0.114 0.886 0.000
H33.3 Retinal breaks without detachment
0.000 0.886 0.114
H15.9 Disorder of sclera, unspecified
0.113 0.887 0.000
H17.1 Other central corneal opacity
0.112 0.888 0.000
H17.0 Adherent leukoma
0.112 0.888 0.000
H17.8 Other corneal scars and opacities
0.111 0.888 0.000
H18.1 Bullous keratopathy
0.110 0.889 0.000
H18.0 Corneal pigmentations and deposits
0.110 0.890 0.000
E61.1 Iron deficiency
0.000 0.890 0.110
H16.3 Interstitial and deep keratitis
0.106 0.893 0.000
H18.2 Other corneal oedema
0.105 0.895 0.000
H18.7 Other corneal deformities
0.105 0.895 0.000
H30 Chorioretinal inflammation
0.000 0.896 0.104
I83.0 Varicose veins of lower extremities with ulcer
0.100 0.900 0.000
H33.0 Retinal detachment with retinal break
0.000 0.901 0.099
H33.1 Retinoschisis and retinal cysts
0.000 0.901 0.099
I83 Varicose veins of lower extremities
0.099 0.901 0.000
H33.4 Traction detachment of retina
0.000 0.902 0.098
H34 Retinal vascular occlusions
0.000 0.902 0.098
H31 Other disorders of choroid
0.000 0.903 0.097
H16.1 Other superficial keratitis without conjunctivitis
0.095 0.904 0.000
E61.2 Magnesium deficiency
0.000 0.906 0.094
H15.8 Other disorders of sclera
0.094 0.906 0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.094 0.906 0.000
H17.9 Corneal scar and opacity, unspecified
0.093 0.907 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.907 0.092
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.092 0.908 0.000
I83.1 Varicose veins of lower extremities with inflammation
0.091 0.909 0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.090 0.910 0.000
E04.8 Other specified non-toxic goitre
0.000 0.910 0.090
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere
0.090 0.910 0.000
H16.2 Keratoconjunctivitis
0.089 0.911 0.000
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.089 0.911 0.000
H35.8 Other specified retinal disorders
0.000 0.912 0.088
E53.1 Pyridoxine deficiency
0.000 0.912 0.088
E53.0 Riboflavin deficiency
0.000 0.912 0.088
I10-I15 Hypertensive diseases
0.000 0.914 0.086
H30.9 Chorioretinal inflammation, unspecified
0.000 0.914 0.086
H35 Other retinal disorders
0.000 0.915 0.085
H15.0 Scleritis
0.085 0.915 0.000
M45-M49 Spondylopathies
0.085 0.915 0.000
H18.9 Disorder of cornea, unspecified
0.084 0.916 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.002 0.917 0.080
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.002 0.917 0.080
M06.04 Seronegative rheumatoid arthritis (Hand)
0.002 0.917 0.080
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.002 0.917 0.080
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.002 0.917 0.080
H18.8 Other specified disorders of cornea
0.081 0.919 0.000
H15.1 Episcleritis
0.081 0.919 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.920 0.080
E04.9 Non-toxic goitre, unspecified
0.000 0.922 0.078
H34.2 Other retinal artery occlusions
0.000 0.922 0.078
K50.0 Crohn's disease of small intestine
0.076 0.924 0.000
H31.1 Choroidal degeneration
0.000 0.924 0.076

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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