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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs507778
log Bayes Factor = 74.1016
Chromosome 6   position 32,209,861  (GRCh37) Explore rs507778 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
N18 Chronic renal failure
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
N00-N08 Glomerular diseases
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
N17-N19 Renal failure
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
D60-D64 Aplastic and other anaemias
1.000 0.000 0.000
M15-M19 Arthrosis
1.000 0.000 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M20-M25 Other joint disorders
1.000 0.000 0.000
M06 Other rheumatoid arthritis
0.000 0.001 0.999
E10.1 With ketoacidosis
0.999 0.001 0.000
D64 Other anaemias
0.999 0.001 0.000
D64.9 Anaemia, unspecified
0.999 0.001 0.000
N04 Nephrotic syndrome
0.999 0.001 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.999 0.001 0.000
E14 Unspecified diabetes mellitus
0.998 0.002 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.002 0.998
M17 Gonarthrosis [arthrosis of knee]
0.998 0.002 0.000
E16 Other disorders of pancreatic internal secretion
0.998 0.002 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.003 0.997
M18 Arthrosis of first carpometacarpal joint
0.996 0.004 0.000
D50-D53 Nutritional anaemias
0.996 0.004 0.000
M17.1 Other primary gonarthrosis
0.996 0.004 0.000
E16.2 Hypoglycaemia, unspecified
0.996 0.004 0.000
N05 Unspecified nephritic syndrome
0.995 0.005 0.000
D80-D89 Certain disorders involving the immune mechanism
0.995 0.005 0.000
N18.3 Chronic kidney disease, stage 3
0.995 0.005 0.000
M05-M14 Inflammatory polyarthropathies
0.009 0.006 0.985
M05 Seropositive rheumatoid arthritis
0.004 0.006 0.989
N04.9 Unspecified
0.993 0.007 0.000
Chapter VII Diseases of the eye and adnexa
0.992 0.008 0.000
D86 Sarcoidosis
0.991 0.009 0.000
N25-N29 Other disorders of kidney and ureter
0.990 0.010 0.000
D50 Iron deficiency anaemia
0.990 0.010 0.000
N28.9 Disorder of kidney and ureter, unspecified
0.989 0.011 0.000
E20-E35 Disorders of other endocrine glands
0.988 0.012 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.986 0.014 0.000
N18.9 Chronic renal failure, unspecified
0.986 0.014 0.000
M06.3 Rheumatoid nodule
0.000 0.014 0.986
E14.3 With ophthalmic complications
0.986 0.014 0.000
E10.4 With neurological complications
0.985 0.015 0.000
M35 Other systemic involvement of connective tissue
0.984 0.016 0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.984 0.016 0.000
M24 Other specific joint derangements
0.983 0.017 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.983 0.017 0.000
H30-H36 Disorders of choroid and retina
0.982 0.018 0.000
E83.1 Disorders of iron metabolism
0.000 0.022 0.978
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.022 0.978
E27 Other disorders of adrenal gland
0.977 0.023 0.000
D50.9 Iron deficiency anaemia, unspecified
0.977 0.023 0.000
H36 Retinal disorders in diseases classified elsewhere
0.977 0.023 0.000
N18.2 Chronic kidney disease, stage 2
0.976 0.024 0.000
M17.0 Primary gonarthrosis, bilateral
0.976 0.024 0.000
E27.1 Primary adrenocortical insufficiency
0.975 0.025 0.000
M35.0 Sicca syndrome [Sjogren]
0.975 0.025 0.000
H36.0 Diabetic retinopathy
0.973 0.027 0.000
D86.9 Sarcoidosis, unspecified
0.972 0.028 0.000
E10.2 With renal complications
0.969 0.031 0.000
N05.9 Unspecified
0.969 0.031 0.000
N17 Acute renal failure
0.969 0.031 0.000
N05.2 Diffuse membranous glomerulonephritis
0.968 0.032 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.967 0.033 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.967 0.033 0.000
N17.9 Acute renal failure, unspecified
0.959 0.041 0.000
H06.2 Dysthyroid exophthalmos
0.955 0.045 0.000
H02 Other disorders of eyelid
0.955 0.045 0.000
H02.5 Other disorders affecting eyelid function
0.953 0.047 0.000
M23 Internal derangement of knee
0.950 0.050 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.050 0.950
M06.34 Rheumatoid nodule (Hand)
0.000 0.052 0.948
M24.8 Other specific joint derangements, not elsewhere classified
0.947 0.053 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.055 0.945
H00.1 Chalazion
0.000 0.064 0.936
M23.3 Other meniscus derangements
0.930 0.070 0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)
0.929 0.071 0.000
H34 Retinal vascular occlusions
0.929 0.071 0.000
M33 Dermatopolymyositis
0.914 0.086 0.000
N04.2 Diffuse membranous glomerulonephritis
0.910 0.090 0.000
E07 Other disorders of thyroid
0.905 0.095 0.000
D61 Other aplastic anaemias
0.904 0.096 0.000
M60-M63 Disorders of muscles
0.903 0.097 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.903 0.097 0.000
M35.7 Hypermobility syndrome
0.903 0.097 0.000
K40.2 Bilateral inguinal hernia, without obstruction or gangrene
0.000 0.100 0.900
N08.3 Glomerular disorders in diabetes mellitus
0.896 0.104 0.000
K40.9 Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.000 0.105 0.895
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.894 0.106 0.000
E06 Thyroiditis
0.890 0.110 0.000
K40 Inguinal hernia
0.000 0.110 0.890
N18.0 End-stage renal disease
0.884 0.116 0.000
D50.8 Other iron deficiency anaemias
0.881 0.119 0.000
D86.8 Sarcoidosis of other and combined sites
0.880 0.120 0.000
E14.1 With ketoacidosis
0.879 0.121 0.000
H00 Hordeolum and chalazion
0.071 0.122 0.808
H34.8 Other retinal vascular occlusions
0.875 0.125 0.000
E24 Cushing's syndrome
0.871 0.129 0.000
N18.4 Chronic kidney disease, stage 4
0.871 0.129 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.870 0.130 0.000
M24.1 Other articular cartilage disorders
0.867 0.133 0.000
E14.9 Without complications
0.866 0.134 0.000
D51 Vitamin B12 deficiency anaemia
0.860 0.140 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.859 0.141 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.859 0.141 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.858 0.142 0.000
H02.6 Xanthelasma of eyelid
0.853 0.147 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.147 0.853
H02.0 Entropion and trichiasis of eyelid
0.848 0.152 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.844 0.156 0.000
N08.5 Glomerular disorders in systemic connective tissue disorders
0.843 0.157 0.000
N04.1 Focal and segmental glomerular lesions
0.841 0.159 0.000
M33.2 Polymyositis
0.839 0.161 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.838 0.162 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.164 0.836
M60 Myositis
0.833 0.167 0.000
M32 Systemic lupus erythematosus
0.833 0.167 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.169 0.831
D86.0 Sarcoidosis of lung
0.829 0.171 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.171 0.829
D61.9 Aplastic anaemia, unspecified
0.828 0.172 0.000
M23.0 Cystic meniscus
0.826 0.174 0.000
N03 Chronic nephritic syndrome
0.826 0.174 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.826 0.174 0.000
E10.5 With peripheral circulatory complications
0.824 0.176 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.823 0.177 0.000
E14.8 With unspecified complications
0.822 0.178 0.000
E16.1 Other hypoglycaemia
0.820 0.180 0.000
E28 Ovarian dysfunction
0.817 0.183 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.816 0.184 0.000
E07.8 Other specified disorders of thyroid
0.816 0.184 0.000
M80-M85 Disorders of bone density and structure
0.812 0.188 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.808 0.192 0.000
N18.5 Chronic kidney disease, stage 5
0.807 0.193 0.000
M22 Disorders of patella
0.807 0.193 0.000
E10.7 With multiple complications
0.805 0.195 0.000
E24.2 Drug-induced Cushing's syndrome
0.802 0.198 0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.802 0.198 0.000
E10.0 With coma
0.801 0.199 0.000
N05.5 Diffuse mesangiocapillary glomerulonephritis
0.799 0.201 0.000
M24.7 Protrusio acetabuli
0.798 0.202 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.798 0.202 0.000
N05.1 Focal and segmental glomerular lesions
0.796 0.204 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.795 0.205 0.000
E14.4 With neurological complications
0.794 0.206 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.792 0.208 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.208 0.792
M35.1 Other overlap syndromes
0.791 0.209 0.000
E13 Other specified diabetes mellitus
0.790 0.210 0.000
D83 Common variable immunodeficiency
0.784 0.216 0.000
M24.9 Joint derangement, unspecified
0.782 0.218 0.000
E14.2 Withrenal complications
0.781 0.219 0.000
M86-M90 Other osteopathies
0.780 0.220 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.220 0.780
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.777 0.223 0.000
H02.1 Ectropion of eyelid
0.776 0.224 0.000
D52 Folate deficiency anaemia
0.776 0.224 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.225 0.775
H00.0 Hordeolum and other deep inflammation of eyelid
0.013 0.228 0.759
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.230 0.770
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases
0.770 0.230 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.769 0.231 0.000
E29 Testicular dysfunction
0.766 0.234 0.000
M91-M94 Chondropathies
0.765 0.235 0.000
D86.1 Sarcoidosis of lymph nodes
0.761 0.239 0.000
D86.3 Sarcoidosis of skin
0.759 0.241 0.000
E22 Hyperfunction of pituitary gland
0.758 0.241 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.758 0.242 0.000
E31 Polyglandular dysfunction
0.758 0.242 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.757 0.243 0.000
M15 Polyarthrosis
0.756 0.244 0.000
M14 Arthropathies in other diseases classified elsewhere
0.005 0.245 0.750
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.249 0.751
M60.9 Myositis, unspecified
0.750 0.250 0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.750 0.250 0.000
N18.1 Chronic kidney disease, stage 1
0.749 0.250 0.000
D68 Other coagulation defects
0.749 0.251 0.000
N29 Other disorders of kidney and ureter in diseases classified elsewhere
0.747 0.253 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.254 0.746
H34.2 Other retinal artery occlusions
0.745 0.255 0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)
0.744 0.255 0.000
E25 Adrenogenital disorders
0.744 0.256 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.743 0.257 0.000
D82 Immunodeficiency associated with other major defects
0.743 0.257 0.000
N25 Disorders resulting from impaired renal tubular function
0.742 0.258 0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)
0.737 0.263 0.000
D50.1 Sideropenic dysphagia
0.737 0.263 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.266 0.734
D62 Acute posthaemorrhagic anaemia
0.733 0.267 0.000
M25 Other joint disorders, not elsewhere classified
0.731 0.269 0.000
E06.9 Thyroiditis, unspecified
0.731 0.269 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.270 0.730
H30 Chorioretinal inflammation
0.729 0.270 0.000
N00 Acute nephritic syndrome
0.728 0.272 0.000
H05 Disorders of orbit
0.727 0.273 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.727 0.273 0.000
M23.03 Cystic meniscus (Medial collateral ligament or Other and unspecified medial meniscus)
0.725 0.275 0.000
H10-H13 Disorders of conjunctiva
0.720 0.280 0.000
M23.8 Other internal derangements of knee
0.719 0.281 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.718 0.282 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.718 0.282 0.000
M82 Osteoporosis in diseases classified elsewhere
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
N07 Hereditary nephropathy, not elsewhere classified
0.717 0.283 0.000
N06 Isolated proteinuria with specified morphological lesion
0.717 0.283 0.000
N01 Rapidly progressive nephritic syndrome
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E06.1 Subacute thyroiditis
0.716 0.283 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.716 0.284 0.000
D64.4 Congenital dyserythropoietic anaemia
0.716 0.284 0.000
D64.3 Other sideroblastic anaemias
0.716 0.284 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.716 0.284 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.716 0.284 0.000
D64.0 Hereditary sideroblastic anaemia
0.716 0.284 0.000
N04.8 Other
0.716 0.284 0.000
N04.7 Diffuse crescentic glomerulonephritis
0.716 0.284 0.000
N04.6 Dense deposit disease
0.716 0.284 0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis
0.716 0.284 0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis
0.716 0.284 0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis
0.716 0.284 0.000
N04.0 Minor glomerular abnormality
0.716 0.284 0.000
E15 Nondiabetic hypoglycaemic coma
0.716 0.284 0.000
E14.7 With multiple complications
0.715 0.284 0.000
E14.0 With coma
0.715 0.284 0.000
N02 Recurrent and persistent haematuria
0.716 0.284 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.715 0.285 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.715 0.285 0.000
E16.4 Abnormal secretion of gastrin
0.715 0.285 0.000
E16.3 Increased secretion of glucagon
0.715 0.285 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.715 0.285 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.285 0.715
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.285 0.715
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.285 0.715
M18.5 Other secondary arthrosis of first carpometacarpal joint
0.714 0.286 0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral
0.714 0.286 0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint
0.714 0.286 0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral
0.714 0.286 0.000
H50 Other strabismus
0.714 0.286 0.000
N05.6 Dense deposit disease
0.714 0.286 0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis
0.714 0.286 0.000
N05.0 Minor glomerular abnormality
0.714 0.286 0.000
D81 Combined immunodeficiencies
0.713 0.286 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.007 0.287 0.706
M08 Juvenile arthritis
0.007 0.287 0.706
E28.3 Primary ovarian failure
0.713 0.287 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.003 0.287 0.709
M05.1 Rheumatoid lung disease
0.003 0.287 0.709
M05.0 Felty's syndrome
0.003 0.287 0.709
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.712 0.288 0.000
D69 Purpura and other haemorrhagic conditions
0.710 0.290 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.710 0.290 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.708 0.292 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.708 0.292 0.000
E32 Diseases of thymus
0.708 0.292 0.000
E30 Disorders of puberty, not elsewhere classified
0.708 0.292 0.000
E07.9 Disorder of thyroid, unspecified
0.707 0.293 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.293 0.707
M06.38 Rheumatoid nodule (Other)
0.000 0.293 0.707
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.293 0.707
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.293 0.707
M06.33 Rheumatoid nodule (Forearm)
0.000 0.293 0.707
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.293 0.707
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.706 0.294 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.706 0.294 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.706 0.294 0.000
M35.5 Multifocal fibrosclerosis
0.706 0.294 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.706 0.294 0.000
M33.1 Other dermatomyositis
0.706 0.294 0.000
H34.9 Retinal vascular occlusion, unspecified
0.705 0.295 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.704 0.296 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.296 0.704
M86 Osteomyelitis
0.703 0.296 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.703 0.297 0.000
M05.8 Other seropositive rheumatoid arthritis
0.003 0.297 0.700
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.703 0.297 0.000
D64.8 Other specified anaemias
0.703 0.297 0.000
E23 Hypofunction and other disorders of pituitary gland
0.701 0.299 0.000
E27.5 Adrenomedullary hyperfunction
0.701 0.299 0.000
E27.0 Other adrenocortical overactivity
0.701 0.299 0.000
M23.4 Loose body in knee
0.701 0.299 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.700 0.300 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.700 0.300 0.000
N03.1 Focal and segmental glomerular lesions
0.700 0.300 0.000
M22.9 Disorder of patella, unspecified
0.699 0.301 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.697 0.303 0.000
M34 Systemic sclerosis
0.695 0.304 0.000
N17.2 Acute renal failure with medullary necrosis
0.694 0.306 0.000
N08.8 Glomerular disorders in other diseases classified elsewhere
0.693 0.306 0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism
0.693 0.306 0.000
N08.1 Glomerular disorders in neoplastic diseases
0.693 0.306 0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere
0.693 0.306 0.000
H06.3 Other disorders of orbit in diseases classified elsewhere
0.693 0.307 0.000
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.693 0.307 0.000
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.693 0.307 0.000
D53 Other nutritional anaemias
0.693 0.307 0.000
M25.9 Joint disorder, unspecified
0.693 0.307 0.000
E24.0 Pituitary-dependent Cushing's disease
0.689 0.311 0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified
0.688 0.312 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.687 0.313 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.684 0.315 0.000
D55-D59 Haemolytic anaemias
0.683 0.317 0.000
E06.3 Autoimmune thyroiditis
0.683 0.317 0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)
0.683 0.317 0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.682 0.318 0.000
M24.2 Disorder of ligament
0.682 0.318 0.000
E14.5 With peripheral circulatory complications
0.681 0.319 0.000
E03.8 Other specified hypothyroidism
0.679 0.321 0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)
0.679 0.321 0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)
0.679 0.321 0.000
M17.5 Other secondary gonarthrosis
0.677 0.322 0.000
D68.8 Other specified coagulation defects
0.677 0.323 0.000
D61.1 Drug-induced aplastic anaemia
0.677 0.323 0.000
N02.2 Diffuse membranous glomerulonephritis
0.674 0.326 0.000
H46 Optic neuritis
0.674 0.326 0.000
M35.2 Behcet's disease
0.674 0.326 0.000
Chapter XXII Codes for special purposes
0.672 0.328 0.000
M23.5 Chronic instability of knee
0.672 0.328 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.328 0.671
N05.3 Diffuse mesangial proliferative glomerulonephritis
0.671 0.329 0.000
E06.5 Other chronic thyroiditis
0.670 0.330 0.000
M22.8 Other disorders of patella
0.670 0.330 0.000
M23.37 Other meniscus derangements-Capsular lig
0.667 0.333 0.000
M83 Adult osteomalacia
0.667 0.333 0.000
H34.0 Transient retinal artery occlusion
0.666 0.334 0.000
H03.8 Involvement of eyelid in other diseases classified elsewhere
0.666 0.334 0.000
M24.75 Protrusio acetabuli-Pelvic/thigh
0.665 0.335 0.000
M15.2 Bouchard's nodes (with arthropathy)
0.665 0.335 0.000
M60.99 Myositis, unspecified (Site unspecified)
0.664 0.336 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.663 0.337 0.000
K40.0 Bilateral inguinal hernia, with obstruction, without gangrene
0.000 0.337 0.663
M21 Other acquired deformities of limbs
0.662 0.338 0.000
H03.1 Involvement of eyelid in other infectious diseases classified elsewhere
0.661 0.339 0.000
M06.4 Inflammatory polyarthropathy
0.000 0.340 0.660
M12 Other specific arthropathies
0.007 0.343 0.650
N19 Unspecified renal failure
0.657 0.343 0.000
M05.2 Rheumatoid vasculitis
0.004 0.344 0.652
M33.9 Dermatopolymyositis, unspecified
0.656 0.344 0.000
M33.0 Juvenile dermatomyositis
0.656 0.344 0.000
M80 Osteoporosis with pathological fracture
0.655 0.345 0.000
D63.0 Anaemia in neoplastic disease
0.655 0.345 0.000
E40-E46 Malnutrition
0.652 0.348 0.000
M62 Other disorders of muscle
0.652 0.348 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.651 0.349 0.000
M82.1 Osteoporosis in endocrine disorders
0.649 0.351 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.649 0.351 0.000
M23.06 Cystic meniscus (Other and unspecified lateral meniscus)
0.649 0.351 0.000
E07.1 Dyshormogenetic goitre
0.649 0.351 0.000
E07.0 Hypersecretion of calcitonin
0.649 0.351 0.000
D61.8 Other specified aplastic anaemias
0.648 0.352 0.000
D61.3 Idiopathic aplastic anaemia
0.648 0.352 0.000
D61.2 Aplastic anaemia due to other external agents
0.648 0.352 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.648 0.352 0.000
D68.2 Hereditary deficiency of other clotting factors
0.648 0.352 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.648 0.352 0.000
M61 Calcification and ossification of muscle
0.648 0.352 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.646 0.354 0.000
M24.6 Ankylosis of joint
0.646 0.354 0.000
D61.0 Constitutional aplastic anaemia
0.646 0.354 0.000
M22.2 Patellofemoral disorders
0.645 0.355 0.000
N17.1 Acute renal failure with acute cortical necrosis
0.642 0.357 0.000
N18.8 Other chronic renal failure
0.642 0.358 0.000
E13.9 Without complications
0.640 0.360 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.361 0.639
E06.4 Drug-induced thyroiditis
0.638 0.362 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.638 0.362 0.000
E06.0 Acute thyroiditis
0.638 0.362 0.000
K40.1 Bilateral inguinal hernia, with gangrene
0.000 0.362 0.638
M24.96 Joint derangement, unspecified (Lower leg)
0.638 0.362 0.000
M94 Other disorders of cartilage
0.636 0.363 0.000
Q60-Q64 Congenital malformations of the urinary system
0.636 0.364 0.000
D67 Hereditary factor IX deficiency
0.635 0.365 0.000
E03.1 Congenital hypothyroidism without goitre
0.634 0.365 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.634 0.366 0.000
M24.5 Contracture of joint
0.633 0.367 0.000
N27 Small kidney of unknown cause
0.633 0.367 0.000
D83.9 Common variable immunodeficiency, unspecified
0.633 0.367 0.000
H49 Paralytic strabismus
0.632 0.368 0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)
0.631 0.369 0.000
D63.8 Anaemia in other chronic diseases classified elsewhere
0.628 0.372 0.000
K40.4 Unilateral or unspecified inguinal hernia, with gangrene
0.000 0.375 0.625
N03.8 Other
0.625 0.375 0.000
H50.5 Heterophoria
0.625 0.375 0.000
E24.8 Other Cushing's syndrome
0.625 0.375 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.625 0.375 0.000
E24.3 Ectopic ACTH syndrome
0.625 0.375 0.000
E24.1 Nelson's syndrome
0.625 0.375 0.000
D89.3 Immune reconstitution syndrome
0.624 0.376 0.000
M24.19 Other articular cartilage disorders (Site unspecified)
0.621 0.378 0.000
M24.18 Other articular cartilage disorders (Other)
0.621 0.378 0.000
M24.14 Other articular cartilage disorders (Hand)
0.621 0.378 0.000
M24.12 Other articular cartilage disorders (Upper arm)
0.621 0.378 0.000
M24.10 Other articular cartilage disorders (Multiple sites)
0.621 0.378 0.000
H02.2 Lagophthalmos
0.621 0.379 0.000
H34.1 Central retinal artery occlusion
0.621 0.379 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.619 0.381 0.000
D52.9 Folate deficiency anaemia, unspecified
0.618 0.382 0.000
E20 Hypoparathyroidism
0.617 0.383 0.000
D51.2 Transcobalamin II deficiency
0.616 0.384 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.616 0.384 0.000
H50.2 Vertical strabismus
0.616 0.384 0.000
M24.49 Recurrent dislocation and subluxation of joint (Site unspecified)
0.615 0.385 0.000
M24.48 Recurrent dislocation and subluxation of joint (Other)
0.615 0.385 0.000
M24.46 Recurrent dislocation and subluxation of joint (Lower leg)
0.615 0.385 0.000
M24.43 Recurrent dislocation and subluxation of joint (Forearm)
0.615 0.385 0.000
M24.42 Recurrent dislocation and subluxation of joint (Upper arm)
0.615 0.385 0.000
M24.40 Recurrent dislocation and subluxation of joint (Multiple sites)
0.615 0.385 0.000
M23.1 Discoid meniscus (congenital)
0.614 0.386 0.000
M25.97 Joint disorder, unspecified (Ankle and foot)
0.613 0.387 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.388 0.612
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.612 0.388 0.000
E22.1 Hyperprolactinaemia
0.612 0.388 0.000
D69.6 Thrombocytopenia, unspecified
0.610 0.390 0.000
D89.2 Hypergammaglobulinaemia, unspecified
0.610 0.390 0.000
M00-M03 Infectious arthropathies
0.609 0.390 0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.609 0.391 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.608 0.392 0.000
M22.3 Other derangements of patella
0.608 0.392 0.000
E29.1 Testicular hypofunction
0.607 0.393 0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.607 0.393 0.000
H35 Other retinal disorders
0.607 0.393 0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)
0.606 0.394 0.000
H50.0 Convergent concomitant strabismus
0.605 0.395 0.000
E10.8 With unspecified complications
0.604 0.396 0.000
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)
0.604 0.396 0.000
M60.95 Myositis, unspecified (Pelvic region and thigh)
0.603 0.397 0.000
N17.0 Acute renal failure with tubular necrosis
0.603 0.397 0.000
M35.8 Other specified systemic involvement of connective tissue
0.600 0.399 0.000
M60.0 Infective myositis
0.600 0.400 0.000
E50-E64 Other nutritional deficiencies
0.599 0.401 0.000
Q50-Q56 Congenital malformations of genital organs
0.599 0.401 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.598 0.402 0.000
M60.8 Other myositis
0.597 0.403 0.000
M60.1 Interstitial myositis
0.597 0.403 0.000
M32.9 Systemic lupus erythematosus, unspecified
0.597 0.403 0.000
M32.0 Drug-induced systemic lupus erythematosus
0.597 0.403 0.000
M21.0 Valgus deformity, not elsewhere classified
0.597 0.403 0.000
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.595 0.405 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.595 0.405 0.000
M25.0 Haemarthrosis
0.595 0.405 0.000
D69.4 Other primary thrombocytopenia
0.595 0.405 0.000
D89.1 Cryoglobulinaemia
0.594 0.405 0.000
M24.44 Recurrent dislocation and subluxation of joint (Hand)
0.594 0.406 0.000
E31.0 Autoimmune polyglandular failure
0.593 0.407 0.000
M23.07 Cystic meniscus-Capsular lig
0.592 0.407 0.000
M23.05 Cystic meniscus (Posterior horn of lateral meniscus)
0.592 0.407 0.000
M23.02 Cystic meniscus (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.592 0.407 0.000
M23.01 Cystic meniscus (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.592 0.407 0.000
M23.00 Cystic meniscus (Multiple sites)
0.592 0.407 0.000
N03.7 Diffuse crescentic glomerulonephritis
0.592 0.408 0.000
N03.6 Dense deposit disease
0.592 0.408 0.000
N03.4 Diffuse endocapillary proliferative glomerulonephritis
0.592 0.408 0.000
N03.3 Diffuse mesangial proliferative glomerulonephritis
0.592 0.408 0.000
N03.2 Diffuse membranous glomerulonephritis
0.592 0.408 0.000
N03.0 Minor glomerular abnormality
0.592 0.408 0.000
H03.0 Parasitic infestation of eyelid in diseases classified elsewhere
0.592 0.408 0.000
E10.6 With other specified complications
0.590 0.409 0.000
N29.1 Other disorders of kidney and ureter in infectious and parasitic diseases classified elsewhere
0.590 0.410 0.000
N03.5 Diffuse mesangiocapillary glomerulonephritis
0.590 0.410 0.000
M23.80 Other internal derangements of knee (Multiple sites)
0.590 0.410 0.000
M90 Osteopathies in diseases classified elsewhere
0.589 0.411 0.000
N05.7 Diffuse crescentic glomerulonephritis
0.588 0.412 0.000
M32.8 Other forms of systemic lupus erythematosus
0.587 0.413 0.000
M93 Other osteochondropathies
0.587 0.413 0.000
E23.7 Disorder of pituitary gland, unspecified
0.587 0.413 0.000
E28.9 Ovarian dysfunction, unspecified
0.586 0.414 0.000
E28.8 Other ovarian dysfunction
0.586 0.414 0.000
E28.1 Androgen excess
0.586 0.414 0.000
E28.0 Oestrogen excess
0.586 0.414 0.000
M86.9 Osteomyelitis, unspecified
0.586 0.414 0.000
D63.1 Anaemia in other chronic diseases classified elsewhere
0.585 0.415 0.000
M60.24 Foreign body granuloma of soft tissue, not elsewhere classified (Hand)
0.585 0.415 0.000
M85 Other disorders of bone density and structure
0.585 0.415 0.000
M23.49 Loose body in knee-Unspec lig/men
0.582 0.418 0.000
E27.9 Disorder of adrenal gland, unspecified
0.579 0.421 0.000
M22.1 Recurrent subluxation of patella
0.579 0.421 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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