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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs537581
log Bayes Factor = 41.0661
Chromosome 6   position 25,886,497  (GRCh37) Explore rs537581 on Ensembl!
Variant rs537581 is part of Cluster X0281

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
H93.1 Tinnitus
0.000 0.357 0.643
H93 Other disorders of ear, not elsewhere classified
0.000 0.400 0.600
K90 Intestinal malabsorption
0.000 0.423 0.577
H90-H95 Other disorders of ear
0.000 0.468 0.532
H92 Otalgia and effusion of ear
0.000 0.474 0.526
H93.9 Disorder of ear, unspecified
0.000 0.483 0.517
H92.1 Otorrhoea
0.000 0.488 0.512
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.521 0.479
H92.0 Otalgia
0.000 0.523 0.477
H93.8 Other specified disorders of ear
0.000 0.543 0.457
K90.8 Other intestinal malabsorption
0.000 0.545 0.455
H93.2 Other abnormal auditory perceptions
0.000 0.570 0.430
H93.0 Degenerative and vascular disorders of ear
0.000 0.570 0.430
H93.3 Disorders of acoustic nerve
0.000 0.584 0.416
K90.3 Pancreatic steatorrhoea
0.000 0.586 0.414
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.586 0.414
K90.1 Tropical sprue
0.000 0.586 0.414
H94 Other disorders of ear in diseases classified elsewhere
0.000 0.618 0.381
K90.9 Intestinal malabsorption, unspecified
0.000 0.626 0.374
H91 Other hearing loss
0.000 0.628 0.372
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.000 0.641 0.359
H92.2 Otorrhagia
0.000 0.651 0.349
H90 Conductive and sensorineural hearing loss
0.000 0.696 0.304
H91.9 Hearing loss, unspecified
0.000 0.711 0.289
H91.3 Deaf mutism, not elsewhere classified
0.000 0.715 0.285
H94.8 Other specified disorders of ear in diseases classified elsewhere
0.000 0.726 0.274
H94.0 Acoustic neuritis in infectious and parasitic diseases classified elsewhere
0.000 0.726 0.274
H95.1 Other disorders following mastoidectomy
0.000 0.729 0.270
H91.1 Presbycusis
0.000 0.736 0.264
E83 Disorders of mineral metabolism
0.000 0.737 0.263
H95.8 Other postprocedural disorders of ear and mastoid process
0.000 0.742 0.257
H91.8 Other specified hearing loss
0.000 0.748 0.252
H91.2 Sudden idiopathic hearing loss
0.000 0.752 0.248
H91.0 Ototoxic hearing loss
0.000 0.757 0.243
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.000 0.760 0.240
H95.9 Postprocedural disorder of ear and mastoid process, unspecified
0.000 0.760 0.240
H90.8 Mixed conductive and sensorineural hearing loss, unspecified
0.000 0.761 0.239
H95.0 Recurrent cholesteatoma of postmastoidectomy cavity
0.000 0.762 0.237
H90.0 Conductive hearing loss, bilateral
0.000 0.766 0.234
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.000 0.772 0.228
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.000 0.785 0.215
H90.5 Sensorineural hearing loss, unspecified
0.000 0.792 0.208
H90.2 Conductive hearing loss, unspecified
0.000 0.796 0.204
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.811 0.189
E83.8 Other disorders of mineral metabolism
0.000 0.811 0.189
E83.2 Disorders of zinc metabolism
0.000 0.811 0.189
E83.0 Disorders of copper metabolism
0.000 0.811 0.189
E83.4 Disorders of magnesium metabolism
0.000 0.821 0.179
E83.3 Disorders of phosphorus metabolism
0.000 0.825 0.175
H90.3 Sensorineural hearing loss, bilateral
0.000 0.850 0.150
H90.6 Mixed conductive and sensorineural hearing loss, bilateral
0.000 0.859 0.141
K51 Ulcerative colitis
0.134 0.866 0.000
K51.9 Ulcerative colitis, unspecified
0.133 0.867 0.000
K51.8 Other ulcerative colitis
0.130 0.870 0.000
E10.9 Without complications
0.000 0.877 0.123
K51.4 Pseudopolyposis of colon
0.121 0.879 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.121 0.879 0.000
E83.5 Disorders of calcium metabolism
0.000 0.879 0.121
K51.2 Ulcerative (chronic) proctitis
0.118 0.882 0.000
K51.1 Ulcerative (chronic) ileocolitis
0.101 0.899 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.902 0.098
K51.0 Ulcerative (chronic) enterocolitis
0.097 0.903 0.000
E10.4 With neurological complications
0.000 0.913 0.087
E10.6 With other specified complications
0.000 0.917 0.083
E10.3 With ophthalmic complications
0.000 0.920 0.080
E10.5 With peripheral circulatory complications
0.000 0.921 0.079
E10.8 With unspecified complications
0.000 0.928 0.072
E10.7 With multiple complications
0.000 0.930 0.070
E10.0 With coma
0.000 0.935 0.064
K51.5 Mucosal proctocolitis
0.060 0.940 0.000
E10-E14 Diabetes mellitus
0.000 0.942 0.058
E70-E90 Metabolic disorders
0.000 0.946 0.054
E10.2 With renal complications
0.000 0.946 0.053
E14 Unspecified diabetes mellitus
0.000 0.950 0.050
E87.0 Hyperosmolality and hypernatraemia
0.000 0.951 0.049
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.954 0.046
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.955 0.045
E14.1 With ketoacidosis
0.000 0.957 0.043
E79 Disorders of purine and pyrimidine metabolism
0.000 0.957 0.043
E12 Malnutrition-related diabetes mellitus
0.000 0.958 0.041
E73 Lactose intolerance
0.000 0.959 0.041
E14.6 With other specified complications
0.000 0.959 0.041
E87.5 Hyperkalaemia
0.000 0.959 0.041
E77 Disorders of glycoprotein metabolism
0.000 0.961 0.039
E76 Disorders of glycosaminoglycan metabolism
0.000 0.961 0.039
E72 Other disorders of amino-acid metabolism
0.000 0.961 0.039
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.961 0.039
E70 Disorders of aromatic amino-acid metabolism
0.000 0.961 0.039
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.961 0.039
E14.8 With unspecified complications
0.000 0.961 0.039
E84 Cystic fibrosis
0.000 0.961 0.039
E14.3 With ophthalmic complications
0.000 0.961 0.039
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.962 0.038
E88 Other metabolic disorders
0.000 0.962 0.038
K90-K93 Other diseases of the digestive system
0.000 0.962 0.038
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.963 0.037
E14.4 With neurological complications
0.000 0.963 0.037
Chapter VIII Diseases of the ear and mastoid process
0.000 0.963 0.037
E14.7 With multiple complications
0.000 0.964 0.036
E14.0 With coma
0.000 0.964 0.036
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.964 0.035
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.965 0.035
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.965 0.035
E14.2 Withrenal complications
0.000 0.965 0.035
E74 Other disorders of carbohydrate metabolism
0.000 0.965 0.035
E40-E46 Malnutrition
0.000 0.966 0.034
E13 Other specified diabetes mellitus
0.000 0.966 0.034
E50-E64 Other nutritional deficiencies
0.000 0.967 0.033
E87.4 Mixed disorder of acid-base balance
0.000 0.967 0.033
E14.5 With peripheral circulatory complications
0.000 0.967 0.033
E73.9 Lactose intolerance, unspecified
0.000 0.968 0.032
E14.9 Without complications
0.000 0.968 0.032
E89.0 Postprocedural hypothyroidism
0.000 0.968 0.032
E16 Other disorders of pancreatic internal secretion
0.000 0.968 0.032
E61 Deficiency of other nutrient elements
0.000 0.969 0.031
E85 Amyloidosis
0.000 0.969 0.031
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.969 0.031
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.969 0.031
E79.1 Lesch-Nyhan syndrome
0.000 0.969 0.031
E88.2 Lipomatosis, not elsewhere classified
0.000 0.969 0.031
E16.2 Hypoglycaemia, unspecified
0.000 0.969 0.031
E12.9 Without complications
0.000 0.970 0.030
E12.8 With unspecified complications
0.000 0.970 0.030
E12.7 With multiple complications
0.000 0.970 0.030
E12.6 With other specified complications
0.000 0.970 0.030
E12.5 With peripheral circulatory complications
0.000 0.970 0.030
E12.4 With neurological complications
0.000 0.970 0.030
E12.3 With ophthalmic complications
0.000 0.970 0.030
E12.2 With renal complications
0.000 0.970 0.030
E12.1 With ketoacidosis
0.000 0.970 0.030
E12.0 With coma
0.000 0.970 0.030
E73.8 Other lactose intolerance
0.000 0.970 0.030
E73.1 Secondary lactase deficiency
0.000 0.970 0.030
E73.0 Congenital lactase deficiency
0.000 0.970 0.030
E61.1 Iron deficiency
0.000 0.971 0.029
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.971 0.029
E88.3 Tumour lysis syndrome
0.000 0.971 0.029
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.972 0.028
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.972 0.028
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.972 0.028
E70.3 Albinism
0.000 0.972 0.028
E70.2 Disorders of tyrosine metabolism
0.000 0.972 0.028
E70.1 Other hyperphenylalaninaemias
0.000 0.972 0.028
E70.0 Classical phenylketonuria
0.000 0.972 0.028
E71.3 Disorders of fatty-acid metabolism
0.000 0.972 0.028
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.972 0.028
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.972 0.028
E71.0 Maple-syrup-urine disease
0.000 0.972 0.028
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.972 0.028
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.972 0.028
E72.5 Disorders of glycine metabolism
0.000 0.972 0.028
E72.4 Disorders of ornithine metabolism
0.000 0.972 0.028
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.972 0.028
E72.2 Disorders of urea cycle metabolism
0.000 0.972 0.028
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.972 0.028
E72.0 Disorders of amino-acid transport
0.000 0.972 0.028
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.972 0.028
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.972 0.028
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.972 0.028
E76.2 Other mucopolysaccharidoses
0.000 0.972 0.028
E76.1 Mucopolysaccharidosis, type II
0.000 0.972 0.028
E76.0 Mucopolysaccharidosis, type I
0.000 0.972 0.028
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.972 0.028
E77.8 Other disorders of glycoprotein metabolism
0.000 0.972 0.028
E77.1 Defects in glycoprotein degradation
0.000 0.972 0.028
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.972 0.028
E84.8 Cystic fibrosis with other manifestations
0.000 0.972 0.028
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.972 0.028
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.972 0.028
E88.8 Other specified metabolic disorders
0.000 0.972 0.028
E84.9 Cystic fibrosis, unspecified
0.000 0.972 0.028
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.972 0.028
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.972 0.028
E89.5 Postprocedural testicular hypofunction
0.000 0.972 0.028
E89.1 Postprocedural hypoinsulinaemia
0.000 0.972 0.028
E88.9 Metabolic disorder, unspecified
0.000 0.972 0.027
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.973 0.027
E15 Nondiabetic hypoglycaemic coma
0.000 0.973 0.027
E87.7 Fluid overload
0.000 0.973 0.027
E46 Unspecified protein-energy malnutrition
0.000 0.973 0.027
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.974 0.026
E87.3 Alkalosis
0.000 0.974 0.026
E89.3 Postprocedural hypopituitarism
0.000 0.974 0.026
E75.6 Lipid storage disorder, unspecified
0.000 0.974 0.025
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.974 0.025
E75.3 Sphingolipidosis, unspecified
0.000 0.974 0.025
E75.2 Other sphingolipidosis
0.000 0.974 0.025
E75.1 Other gangliosidosis
0.000 0.974 0.025
E75.0 GM2 gangliosidosis
0.000 0.974 0.025
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.975 0.025
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.975 0.025
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.975 0.025
E74.2 Disorders of galactose metabolism
0.000 0.975 0.025
E74.1 Disorders of fructose metabolism
0.000 0.975 0.025
E74.0 Glycogen storage disease
0.000 0.975 0.025
E89.4 Postprocedural ovarian failure
0.000 0.975 0.025
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.975 0.025
E45 Retarded development following protein-energy malnutrition
0.000 0.975 0.025
E43 Unspecified severe protein-energy malnutrition
0.000 0.975 0.025
E42 Marasmic kwashiorkor
0.000 0.975 0.025
E41 Nutritional marasmus
0.000 0.975 0.025
E40 Kwashiorkor
0.000 0.975 0.025
E51 Thiamine deficiency
0.000 0.975 0.025
E13.8 With unspecified complications
0.000 0.975 0.025
E13.7 With multiple complications
0.000 0.975 0.025
E13.6 With other specified complications
0.000 0.975 0.025
E13.5 With peripheral circulatory complications
0.000 0.975 0.025
E13.4 With neurological complications
0.000 0.975 0.025
E13.2 With renal complications
0.000 0.975 0.025
E13.1 With ketoacidosis
0.000 0.975 0.025
E13.0 With coma
0.000 0.975 0.025
E61.2 Magnesium deficiency
0.000 0.976 0.024
E89.2 Postprocedural hypoparathyroidism
0.000 0.976 0.024
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.976 0.024
E63 Other nutritional deficiencies
0.000 0.976 0.024
E50 Vitamin A deficiency
0.000 0.976 0.024
E60 Dietary zinc deficiency
0.000 0.976 0.024
E59 Dietary selenium deficiency
0.000 0.976 0.024
E52 Niacin deficiency [pellagra]
0.000 0.976 0.024
H72 Perforation of tympanic membrane
0.000 0.977 0.023
E58 Dietary calcium deficiency
0.000 0.977 0.023
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.977 0.023
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.977 0.023
E16.4 Abnormal secretion of gastrin
0.000 0.977 0.023
E16.3 Increased secretion of glucagon
0.000 0.977 0.023
E61.9 Deficiency of nutrient element, unspecified
0.000 0.977 0.022
E61.8 Deficiency of other specified nutrient elements
0.000 0.977 0.022
E61.7 Deficiency of multiple nutrient elements
0.000 0.977 0.022
E61.6 Vanadium deficiency
0.000 0.977 0.022
E61.5 Molybdenum deficiency
0.000 0.977 0.022
E61.4 Chromium deficiency
0.000 0.977 0.022
E61.3 Manganese deficiency
0.000 0.977 0.022
E61.0 Copper deficiency
0.000 0.977 0.022
E85.8 Other amyloidosis
0.000 0.977 0.022
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.977 0.022
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.977 0.022
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.977 0.022
E13.3 With ophthalmic complications
0.000 0.978 0.022
E75.5 Other lipid storage disorders
0.000 0.978 0.022
H72.8 Other perforations of tympanic membrane
0.000 0.978 0.022
E85.9 Amyloidosis, unspecified
0.000 0.978 0.022
C71 Malignant neoplasm of brain
0.022 0.978 0.000
E87.6 Hypokalaemia
0.000 0.978 0.022
E56 Other vitamin deficiencies
0.000 0.978 0.022
E10.1 With ketoacidosis
0.000 0.978 0.021
E85.4 Organ-limited amyloidosis
0.000 0.978 0.021
H72.9 Perforation of tympanic membrane, unspecified
0.000 0.978 0.022
H65-H75 Diseases of middle ear and mastoid
0.000 0.979 0.021
C71.3 Parietal lobe
0.021 0.979 0.000
C71.9 Brain, unspecified
0.021 0.979 0.000
E13.9 Without complications
0.000 0.979 0.021
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.979 0.020
C71.2 Temporal lobe
0.020 0.980 0.000
E55 Vitamin D deficiency
0.000 0.980 0.020
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.980 0.020
K93.1 Megacolon in Chagas' disease
0.000 0.980 0.020
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.980 0.020
E54 Ascorbic acid deficiency
0.000 0.980 0.020
E53 Deficiency of other B group vitamins
0.000 0.980 0.020
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.981 0.019
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.981 0.019
E80.5 Crigler-Najjar syndrome
0.000 0.981 0.019
E80.3 Defects of catalase and peroxydase
0.000 0.981 0.019
E80.1 Porphyria cutanea tarda
0.000 0.981 0.019
E80.0 Hereditary erythropoietic porphyria
0.000 0.981 0.019
E80.6 Other disorders of bilirubin metabolism
0.000 0.981 0.019
E51.2 Wernicke's encephalopathy
0.000 0.981 0.019
H72.2 Other marginal perforations of tympanic membrane
0.000 0.982 0.018
E44.1 Mild protein-energy malnutrition
0.000 0.982 0.018
E44.0 Moderate protein-energy malnutrition
0.000 0.982 0.018
E51.9 Thiamine deficiency, unspecified
0.000 0.982 0.018
E51.8 Other manifestations of thiamine deficiency
0.000 0.982 0.018
E51.1 Beriberi
0.000 0.982 0.018
H72.1 Attic perforation of tympanic membrane
0.000 0.982 0.018
E16.1 Other hypoglycaemia
0.000 0.982 0.018
E80.2 Other porphyria
0.000 0.982 0.018
C71.1 Frontal lobe
0.018 0.982 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.983 0.017
E50.8 Other manifestations of vitamin A deficiency
0.000 0.983 0.017
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.983 0.017
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.983 0.017
E50.5 Vitamin A deficiency with night blindness
0.000 0.983 0.017
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.983 0.017
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.983 0.017
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.983 0.017
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.983 0.017
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.983 0.017
E63.9 Nutritional deficiency, unspecified
0.000 0.983 0.017
E63.8 Other specified nutritional deficiencies
0.000 0.983 0.017
E63.1 Imbalance of constituents of food intake
0.000 0.983 0.017
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.983 0.017
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.983 0.017
E64.8 Sequelae of other nutritional deficiencies
0.000 0.983 0.017
E64.3 Sequelae of rickets
0.000 0.983 0.017
E64.2 Sequelae of vitamin C deficiency
0.000 0.983 0.017
E64.1 Sequelae of vitamin A deficiency
0.000 0.983 0.017
E64.0 Sequelae of protein-energy malnutrition
0.000 0.983 0.017
C71.0 Cerebrum, except lobes and ventricles
0.017 0.983 0.000
E85.3 Secondary systemic amyloidosis
0.000 0.983 0.017
E53.9 Vitamin B deficiency, unspecified
0.000 0.983 0.017
H72.0 Central perforation of tympanic membrane
0.000 0.983 0.017
H69 Other disorders of Eustachian tube
0.000 0.983 0.017
C71.4 Occipital lobe
0.016 0.983 0.000
H66 Suppurative and unspecified otitis media
0.000 0.984 0.016
C71.7 Brain stem
0.016 0.984 0.000
C71.6 Cerebellum
0.016 0.984 0.000
C71.5 Cerebral ventricle
0.016 0.984 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.984 0.016
E56.8 Deficiency of other vitamins
0.000 0.984 0.016
E56.0 Deficiency of vitamin E
0.000 0.984 0.016
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.984 0.016
H67 Otitis media in diseases classified elsewhere
0.000 0.984 0.016
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.984 0.015
C71.8 Overlapping lesion of brain
0.015 0.985 0.000
E55.0 Rickets, active
0.000 0.985 0.015
H68 Eustachian salpingitis and obstruction
0.000 0.985 0.015
H66.9 Otitis media, unspecified
0.000 0.985 0.015
E53.1 Pyridoxine deficiency
0.000 0.986 0.014
E53.0 Riboflavin deficiency
0.000 0.986 0.014
E87.2 Acidosis
0.000 0.986 0.014
E56.1 Deficiency of vitamin K
0.000 0.986 0.013
H70 Mastoiditis and related conditions
0.000 0.986 0.013
E20-E35 Disorders of other endocrine glands
0.000 0.986 0.014
E65-E68 Obesity and other hyperalimentation
0.000 0.987 0.013
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.987 0.013
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)
0.000 0.987 0.013
H69.8 Other specified disorders of Eustachian tube
0.000 0.987 0.013
K50-K52 Noninfective enteritis and colitis
0.013 0.987 0.000
H66.1 Chronic tubotympanic suppurative otitis media
0.000 0.987 0.013
H66.2 Chronic atticoantral suppurative otitis media
0.000 0.987 0.012
H80-H83 Diseases of inner ear
0.000 0.988 0.012
H69.0 Patulous Eustachian tube
0.000 0.988 0.012
H71 Cholesteatoma of middle ear
0.000 0.988 0.012
H69.9 Eustachian tube disorder, unspecified
0.000 0.988 0.012
H67.8 Otitis media in other diseases classified elsewhere
0.000 0.988 0.011
H67.1 Otitis media in viral diseases classified elsewhere
0.000 0.988 0.011
H67.0 Otitis media in bacterial diseases classified elsewhere
0.000 0.988 0.011
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.988 0.011
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
0.000 0.988 0.011
E23 Hypofunction and other disorders of pituitary gland
0.000 0.989 0.011
D06.9 Cervix, unspecified
0.011 0.989 0.000
H66.0 Acute suppurative otitis media
0.000 0.989 0.011
E55.9 Vitamin D deficiency, unspecified
0.000 0.989 0.011
H66.4 Suppurative otitis media, unspecified
0.000 0.989 0.011
E20 Hypoparathyroidism
0.000 0.989 0.011
H68.0 Eustachian salpingitis
0.000 0.989 0.011
E25 Adrenogenital disorders
0.000 0.989 0.010
M87.9 Osteonecrosis, unspecified
0.000 0.990 0.010
H70.2 Petrositis
0.000 0.990 0.010
H70.0 Acute mastoiditis
0.000 0.990 0.010
H70.9 Mastoiditis, unspecified
0.000 0.990 0.010
H68.1 Obstruction of Eustachian tube
0.000 0.990 0.010
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.990 0.010
E32 Diseases of thymus
0.000 0.990 0.010
E31 Polyglandular dysfunction
0.000 0.990 0.010
E30 Disorders of puberty, not elsewhere classified
0.000 0.990 0.010
E67 Other hyperalimentation
0.000 0.990 0.010
E68 Sequelae of hyperalimentation
0.000 0.990 0.010
H73 Other disorders of tympanic membrane
0.000 0.990 0.010
E80.4 Gilbert's syndrome
0.000 0.990 0.010
H33.3 Retinal breaks without detachment
0.010 0.990 0.000
E23.7 Disorder of pituitary gland, unspecified
0.000 0.990 0.009
E23.0 Hypopituitarism
0.000 0.990 0.010
M87.97 Osteonecrosis, unspecified (Ankle and foot)
0.000 0.990 0.009
E26 Hyperaldosteronism
0.000 0.990 0.009
E24 Cushing's syndrome
0.000 0.990 0.009
H74.8 Other specified disorders of middle ear and mastoid
0.000 0.991 0.009
H70.8 Other mastoiditis and related conditions
0.000 0.991 0.009
H74 Other disorders of middle ear and mastoid
0.000 0.991 0.009
E86 Volume depletion
0.000 0.991 0.009
E20.9 Hypoparathyroidism, unspecified
0.000 0.991 0.009
H82 Vertiginous syndromes in diseases classified elsewhere
0.000 0.991 0.009
E00-E07 Disorders of thyroid gland
0.000 0.991 0.009
E34 Other endocrine disorders
0.000 0.991 0.009
H70.1 Chronic mastoiditis
0.000 0.991 0.009
H60-H62 Diseases of external ear
0.001 0.991 0.008
M87.96 Osteonecrosis, unspecified (Lower leg)
0.000 0.991 0.009
E27 Other disorders of adrenal gland
0.000 0.991 0.009
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.991 0.009
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.992 0.008
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.992 0.008
E23.1 Drug-induced hypopituitarism
0.000 0.992 0.008
E22 Hyperfunction of pituitary gland
0.000 0.992 0.008
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.992 0.008
E23.6 Other disorders of pituitary gland
0.000 0.992 0.008
E20.8 Other hypoparathyroidism
0.000 0.992 0.008
E20.1 Pseudohypoparathyroidism
0.000 0.992 0.008
E20.0 Idiopathic hypoparathyroidism
0.000 0.992 0.008
M87.91 Osteonecrosis, unspecified (Shoulder region)
0.000 0.992 0.008
E25.9 Adrenogenital disorder, unspecified
0.000 0.992 0.008
E25.8 Other adrenogenital disorders
0.000 0.992 0.008
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.008 0.992 0.000
H83 Other diseases of inner ear
0.000 0.992 0.008
E34.9 Endocrine disorder, unspecified
0.000 0.992 0.008
M87.99 Osteonecrosis, unspecified (Site unspecified)
0.000 0.992 0.008
M87.94 Osteonecrosis, unspecified (Hand)
0.000 0.992 0.008
M87.93 Osteonecrosis, unspecified (Forearm)
0.000 0.992 0.008
M87.92 Osteonecrosis, unspecified (Upper arm)
0.000 0.992 0.008
M87.90 Osteonecrosis, unspecified (Multiple sites)
0.000 0.992 0.008
E24.2 Drug-induced Cushing's syndrome
0.000 0.992 0.008
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.992 0.008
E29 Testicular dysfunction
0.000 0.992 0.008
E27.2 Addisonian crisis
0.000 0.992 0.008
E24.9 Cushing's syndrome, unspecified
0.000 0.992 0.007
E30.9 Disorder of puberty, unspecified
0.000 0.993 0.007
E30.8 Other disorders of puberty
0.000 0.993 0.007
E30.1 Precocious puberty
0.000 0.993 0.007
E30.0 Delayed puberty
0.000 0.993 0.007
E31.9 Polyglandular dysfunction, unspecified
0.000 0.993 0.007
E31.8 Other polyglandular dysfunction
0.000 0.993 0.007
E31.1 Polyglandular hyperfunction
0.000 0.993 0.007
E31.0 Autoimmune polyglandular failure
0.000 0.993 0.007
E32.9 Disease of thymus, unspecified
0.000 0.993 0.007
E32.8 Other diseases of thymus
0.000 0.993 0.007
E32.1 Abscess of thymus
0.000 0.993 0.007
E32.0 Persistent hyperplasia of thymus
0.000 0.993 0.007
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.993 0.007
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.993 0.007
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.993 0.007
E78.4 Other hyperlipidaemia
0.000 0.993 0.007
H73.9 Disorder of tympanic membrane, unspecified
0.000 0.993 0.007
E67.8 Other specified hyperalimentation
0.000 0.993 0.007
E67.3 Hypervitaminosis D
0.000 0.993 0.007
E67.2 Megavitamin-B6 syndrome
0.000 0.993 0.007
E67.1 Hypercarotenaemia
0.000 0.993 0.007
E67.0 Hypervitaminosis A
0.000 0.993 0.007
H73.1 Chronic myringitis
0.000 0.993 0.007
S02.20 Fracture of nasal bones (closed)
0.000 0.993 0.007
M87.98 Osteonecrosis, unspecified (Other)
0.000 0.993 0.007
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.993 0.007
E24.3 Ectopic ACTH syndrome
0.000 0.993 0.007
E24.1 Nelson's syndrome
0.000 0.993 0.007
E26.9 Hyperaldosteronism, unspecified
0.000 0.993 0.007
E26.8 Other hyperaldosteronism
0.000 0.993 0.007
E26.1 Secondary hyperaldosteronism
0.000 0.993 0.007
E05.9 Thyrotoxicosis, unspecified
0.000 0.993 0.007
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.993 0.007
E00 Congenital iodine-deficiency syndrome
0.000 0.993 0.007
E34.5 Androgen resistance syndrome
0.000 0.993 0.007
E34.4 Constitutional tall stature
0.000 0.993 0.007
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.993 0.007
E34.1 Other hypersecretion of intestinal hormones
0.000 0.993 0.007
E21.0 Primary hyperparathyroidism
0.000 0.993 0.007
E27.1 Primary adrenocortical insufficiency
0.000 0.993 0.007
E23.2 Diabetes insipidus
0.000 0.993 0.007
E78.1 Pure hyperglyceridaemia
0.000 0.993 0.007
H74.1 Adhesive middle ear disease
0.000 0.993 0.006
E05.8 Other thyrotoxicosis
0.000 0.993 0.007
H83.9 Disease of inner ear, unspecified
0.000 0.993 0.006
E26.0 Primary hyperaldosteronism
0.000 0.993 0.006
E21.3 Hyperparathyroidism, unspecified
0.000 0.993 0.006
E78.6 Lipoprotein deficiency
0.000 0.993 0.006
E27.5 Adrenomedullary hyperfunction
0.000 0.994 0.006
E27.0 Other adrenocortical overactivity
0.000 0.994 0.006
E78.3 Hyperchylomicronaemia
0.000 0.994 0.006
H83.8 Other specified diseases of inner ear
0.000 0.994 0.006
H62 Disorders of external ear in diseases classified elsewhere
0.001 0.994 0.005
E34.8 Other specified endocrine disorders
0.000 0.994 0.006
E24.8 Other Cushing's syndrome
0.000 0.994 0.006
E34.3 Short stature, not elsewhere classified
0.000 0.994 0.006
E21.4 Other specified disorders of parathyroid gland
0.000 0.994 0.006
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.994 0.006
E22.8 Other hyperfunction of pituitary gland
0.000 0.994 0.006
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.994 0.006
E24.0 Pituitary-dependent Cushing's disease
0.000 0.994 0.006
E21.2 Other hyperparathyroidism
0.000 0.994 0.006
H73.0 Acute myringitis
0.000 0.994 0.006
E06 Thyroiditis
0.000 0.994 0.006
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.994 0.006
E78.2 Mixed hyperlipidaemia
0.000 0.994 0.006
H80 Otosclerosis
0.000 0.994 0.006
E07 Other disorders of thyroid
0.000 0.994 0.006
E22.1 Hyperprolactinaemia
0.000 0.994 0.006
H83.3 Noise effects on inner ear
0.000 0.994 0.006
H83.2 Labyrinthine dysfunction
0.000 0.994 0.006
H83.1 Labyrinthine fistula
0.000 0.994 0.006
H74.9 Disorder of middle ear and mastoid, unspecified
0.000 0.994 0.006
E05.5 Thyroid crisis or storm
0.000 0.994 0.006
E05.4 Thyrotoxicosis factitia
0.000 0.994 0.006
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.994 0.006
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.994 0.006
C70 Malignant neoplasm of meninges
0.006 0.994 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.994 0.006
E29.9 Testicular dysfunction, unspecified
0.000 0.994 0.006
E29.8 Other testicular dysfunction
0.000 0.994 0.006
E29.0 Testicular hyperfunction
0.000 0.994 0.006
E28 Ovarian dysfunction
0.001 0.994 0.005
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
0.006 0.994 0.000
E27.8 Other specified disorders of adrenal gland
0.000 0.994 0.005
S02.2 Fracture of nasal bones
0.000 0.994 0.006
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.994 0.005
S06.80 Other intracranial injuries (without open intracranial wound)
0.000 0.994 0.006
E22.0 Acromegaly and pituitary gigantism
0.000 0.994 0.005
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.995 0.005
E65 Localised adiposity
0.001 0.995 0.005
C69 Malignant neoplasm of eye and adnexa
0.005 0.995 0.000
E34.0 Carcinoid syndrome
0.000 0.995 0.005
H74.0 Tympanosclerosis
0.000 0.995 0.005

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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