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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs58116261
log Bayes Factor = 8.77788
Chromosome 12   position 112,935,344  (GRCh37) Explore rs58116261 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
I25.2 Old myocardial infarction
0.000 0.002 0.998
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.008 0.992
I21.9 Acute myocardial infarction, unspecified
0.000 0.012 0.988
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.087 0.913
I22 Subsequent myocardial infarction
0.000 0.134 0.866
I25.5 Ischaemic cardiomyopathy
0.000 0.137 0.863
I21.4 Acute subendocardial myocardial infarction
0.000 0.171 0.829
Chapter IX Diseases of the circulatory system
0.000 0.181 0.819
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.185 0.815
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.215 0.785
I10-I15 Hypertensive diseases
0.000 0.221 0.779
I73 Other peripheral vascular diseases
0.000 0.224 0.776
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.225 0.775
I73.0 Raynaud's syndrome
0.000 0.239 0.761
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.239 0.761
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.240 0.760
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.240 0.760
I10 Essential (primary) hypertension
0.000 0.247 0.753
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.248 0.752
I24 Other acute ischaemic heart diseases
0.000 0.277 0.723
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
Z95.4 Presence of other heart-valve replacement
0.000 0.291 0.709
I05-I09 Chronic rheumatic heart diseases
0.000 0.294 0.706
Z95.1 Presence of aortocoronary bypass graft
0.000 0.303 0.697
I30-I52 Other forms of heart disease
0.000 0.304 0.696
I25.4 Coronary artery aneurysm
0.000 0.318 0.682
Z95.3 Presence of xenogenic heart valve
0.000 0.319 0.681
I73.9 Peripheral vascular disease, unspecified
0.000 0.324 0.676
I49 Other cardiac arrhythmias
0.000 0.324 0.676
I44 Atrioventricular and left bundle-branch block
0.000 0.328 0.672
I49.3 Ventricular premature depolarisation
0.000 0.334 0.666
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.340 0.660
I44.7 Left bundle-branch block, unspecified
0.000 0.344 0.656
I23 Certain current complications following acute myocardial infarction
0.000 0.352 0.648
I74 Arterial embolism and thrombosis
0.000 0.358 0.642
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.361 0.638
I35 Nonrheumatic aortic valve disorders
0.000 0.371 0.629
I25.3 Aneurysm of heart
0.000 0.377 0.623
I49.0 Ventricular fibrillation and flutter
0.000 0.389 0.611
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.390 0.610
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.392 0.608
I72 Other aneurysm
0.000 0.401 0.599
I49.4 Other and unspecified premature depolarisation
0.000 0.402 0.598
I35.0 Aortic (valve) stenosis
0.000 0.406 0.594
I00-I02 Acute rheumatic fever
0.000 0.412 0.587
I36 Nonrheumatic tricuspid valve disorders
0.000 0.413 0.587
I12 Hypertensive renal disease
0.000 0.416 0.584
I07 Rheumatic tricuspid valve diseases
0.000 0.419 0.581
I05 Rheumatic mitral valve diseases
0.000 0.426 0.574
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.442 0.558
I13 Hypertensive heart and renal disease
0.000 0.442 0.558
I73.8 Other specified peripheral vascular diseases
0.000 0.443 0.556
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.443 0.556
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.451 0.549
I08 Multiple valve diseases
0.000 0.453 0.547
I44.6 Other and unspecified fascicular block
0.000 0.457 0.543
I11 Hypertensive heart disease
0.000 0.460 0.540
I71 Aortic aneurysm and dissection
0.000 0.463 0.537
I12.9 Hypertensive renal disease without renal failure
0.000 0.475 0.525
I24.1 Dressler's syndrome
0.000 0.482 0.518
I15 Secondary hypertension
0.000 0.482 0.518
I50 Heart failure
0.000 0.486 0.514
I47 Paroxysmal tachycardia
0.000 0.488 0.512
I74.5 Embolism and thrombosis of iliac artery
0.000 0.488 0.511
I70 Atherosclerosis
0.000 0.489 0.511
I24.8 Other forms of acute ischaemic heart disease
0.000 0.490 0.510
I37 Pulmonary valve disorders
0.000 0.490 0.510
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.491 0.509
I06 Rheumatic aortic valve diseases
0.000 0.494 0.506
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.494 0.505
I52 Other heart disorders in diseases classified elsewhere
0.000 0.501 0.499
I48 Atrial fibrillation and flutter
0.000 0.501 0.499
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.501 0.499
I41 Myocarditis in diseases classified elsewhere
0.000 0.501 0.499
I40 Acute myocarditis
0.000 0.501 0.499
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.501 0.499
I32 Pericarditis in diseases classified elsewhere
0.000 0.501 0.499
I22.8 Subsequent myocardial infarction of other sites
0.000 0.502 0.497
I35.9 Aortic valve disorder, unspecified
0.000 0.506 0.494
I07.1 Tricuspid insufficiency
0.000 0.508 0.492
I05.0 Mitral stenosis
0.000 0.509 0.491
I78 Diseases of capillaries
0.000 0.512 0.488
I44.0 Atrioventricular block, first degree
0.000 0.514 0.486
I49.2 Junctional premature depolarisation
0.000 0.515 0.484
I44.5 Left posterior fascicular block
0.000 0.518 0.482
I44.4 Left anterior fascicular block
0.000 0.518 0.482
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.524 0.476
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.526 0.474
I44.3 Other and unspecified atrioventricular block
0.000 0.527 0.473
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.528 0.472
I72.8 Aneurysm of other specified arteries
0.000 0.532 0.468
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.532 0.468
Z95.2 Presence of prosthetic heart valve
0.000 0.532 0.468
I44.1 Atrioventricular block, second degree
0.000 0.534 0.466
I47.2 Ventricular tachycardia
0.000 0.535 0.465
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.535 0.465
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.535 0.465
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.535 0.465
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.535 0.465
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.535 0.465
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.535 0.465
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.535 0.465
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.538 0.462
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.540 0.460
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.540 0.460
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.540 0.460
I09 Other rheumatic heart diseases
0.000 0.542 0.457
I49.1 Atrial premature depolarisation
0.000 0.546 0.454
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.550 0.450
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.553 0.447
I72.4 Aneurysm of artery of lower extremity
0.000 0.564 0.436
I72.3 Aneurysm of iliac artery
0.000 0.565 0.435
I08.0 Disorders of both mitral and aortic valves
0.000 0.567 0.433
I35.8 Other aortic valve disorders
0.000 0.568 0.432
I72.9 Aneurysm of unspecified site
0.000 0.571 0.429
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.571 0.429
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.571 0.429
I72.2 Aneurysm of renal artery
0.000 0.571 0.429
I72.1 Aneurysm of artery of upper extremity
0.000 0.571 0.429
I35.1 Aortic (valve) insufficiency
0.000 0.579 0.421
I02 Rheumatic chorea
0.000 0.579 0.421
I01 Rheumatic fever with heart involvement
0.000 0.579 0.421
I00 Rheumatic fever without mention of heart involvement
0.000 0.579 0.421
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.579 0.421
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.579 0.421
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.579 0.421
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.579 0.421
I33 Acute and subacute endocarditis
0.000 0.580 0.419
I07.9 Tricuspid valve disease, unspecified
0.000 0.583 0.417
I07.8 Other tricuspid valve diseases
0.000 0.583 0.417
I07.2 Tricuspid stenosis with insufficiency
0.000 0.583 0.417
I07.0 Tricuspid stenosis
0.000 0.583 0.417
I05.1 Rheumatic mitral insufficiency
0.000 0.584 0.416
I46 Cardiac arrest
0.000 0.587 0.413
I05.8 Other mitral valve diseases
0.000 0.588 0.412
I05.2 Mitral stenosis with insufficiency
0.000 0.588 0.412
I72.0 Aneurysm of carotid artery
0.000 0.589 0.411
I50.0 Congestive heart failure
0.000 0.593 0.407
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.597 0.402
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.598 0.401
I44.2 Atrioventricular block, complete
0.000 0.598 0.402
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.600 0.400
I79.1 Aortitis in diseases classified elsewhere
0.000 0.600 0.400
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.600 0.400
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.600 0.400
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.600 0.400
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.600 0.400
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.600 0.400
I23.8 Other current complications following acute myocardial infarction
0.000 0.604 0.396
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.604 0.396
I08.9 Multiple valve disease, unspecified
0.000 0.608 0.392
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.610 0.390
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.612 0.388
I05.9 Mitral valve disease, unspecified
0.000 0.612 0.387
I50.1 Left ventricular failure
0.000 0.614 0.386
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.615 0.385
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.615 0.385
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.615 0.385
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.615 0.385
I70.0 Atherosclerosis of aorta
0.000 0.618 0.382
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.620 0.380
I42 Cardiomyopathy
0.000 0.621 0.379
I74.8 Embolism and thrombosis of other arteries
0.000 0.621 0.378
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.622 0.377
I37.1 Pulmonary valve insufficiency
0.000 0.624 0.376
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.626 0.374
I47.0 Reentry ventricular arrhythmia
0.000 0.628 0.372
I15.9 Seconday hypertension, unspecified
0.000 0.629 0.371
I15.8 Other secondary hypertension
0.000 0.629 0.371
I15.2 Hypertension secondary to endocrine disorders
0.000 0.629 0.371
I15.0 Renovascular hypertension
0.000 0.629 0.371
I49.9 Cardiac arrhythmia, unspecified
0.000 0.629 0.371
I31 Other diseases of pericardium
0.000 0.630 0.370
I30 Acute pericarditis
0.000 0.631 0.369
I70.9 Generalised and unspecified atherosclerosis
0.000 0.633 0.366
I70.8 Atherosclerosis of other arteries
0.000 0.633 0.366
I70.1 Atherosclerosis of renal artery
0.000 0.633 0.366
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.634 0.366
I37.9 Pulmonary valve disorder, unspecified
0.000 0.634 0.365
I37.8 Other pulmonary valve disorders
0.000 0.634 0.365
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.634 0.365
I37.0 Pulmonary valve stenosis
0.000 0.634 0.365
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.637 0.363
I06.8 Other rheumatic aortic valve diseases
0.000 0.637 0.363
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.637 0.363
I06.1 Rheumatic aortic insufficiency
0.000 0.637 0.363
I06.0 Rheumatic aortic stenosis
0.000 0.637 0.363
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.639 0.360
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.642 0.358
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.642 0.358
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.642 0.358
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.642 0.358
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.642 0.358
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.642 0.358
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.642 0.358
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.642 0.358
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.642 0.358
I40.9 Acute myocarditis, unspecified
0.000 0.642 0.358
I40.8 Other acute myocarditis
0.000 0.642 0.358
I40.1 Isolated myocarditis
0.000 0.642 0.358
I40.0 Infective myocarditis
0.000 0.642 0.358
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.642 0.358
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.642 0.358
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.642 0.358
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.642 0.358
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.642 0.358
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.642 0.358
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.642 0.358
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.642 0.358
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.642 0.358
I48.4 Atypical atrial flutter
0.000 0.642 0.358
I48.3 Typical atrial flutter
0.000 0.642 0.358
I48.2 Chronic atrial fibrillation
0.000 0.642 0.358
I48.1 Persistent atrial fibrillation
0.000 0.642 0.358
I48.0 Paroxysmal atrial fibrillation
0.000 0.642 0.358
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.642 0.358
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.642 0.358
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.642 0.358
I99 Other and unspecified disorders of circulatory system
0.000 0.648 0.352
I78.9 Disease of capillaries, unspecified
0.000 0.650 0.350
I20 Angina pectoris
0.000 0.651 0.349
I51 Complications and ill-defined descriptions of heart disease
0.000 0.655 0.345
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.659 0.341
I08.8 Other multiple valve diseases
0.000 0.665 0.335
I78.8 Other diseases of capillaries
0.000 0.666 0.334
I15.1 Hypertension secondary to other renal disorders
0.000 0.669 0.330
I09.8 Other specified rheumatic heart diseases
0.000 0.672 0.328
I09.2 Chronic rheumatic pericarditis
0.000 0.672 0.328
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.672 0.328
I09.0 Rheumatic myocarditis
0.000 0.672 0.328
I38 Endocarditis, valve unspecified
0.000 0.675 0.325
I50.9 Heart failure, unspecified
0.000 0.686 0.314
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.698 0.302
I01.8 Other acute rheumatic heart disease
0.000 0.698 0.302
I01.2 Acute rheumatic myocarditis
0.000 0.698 0.302
I01.1 Acute rheumatic endocarditis
0.000 0.698 0.302
I01.0 Acute rheumatic pericarditis
0.000 0.698 0.302
I02.9 Rheumatic chorea without heart involvement
0.000 0.698 0.302
I02.0 Rheumatic chorea with heart involvement
0.000 0.698 0.302
I33.9 Acute endocarditis, unspecified
0.000 0.699 0.301
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.703 0.297
I46.1 Sudden cardiac death, so described
0.000 0.704 0.296
I97.1 Other functional disturbances following cardiac surgery
0.000 0.707 0.293
I42.0 Dilated cardiomyopathy
0.000 0.708 0.292
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.709 0.291
I71.0 Dissection of aorta [any part]
0.000 0.710 0.290
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.711 0.289
I46.9 Cardiac arrest, unspecified
0.000 0.713 0.287
I51.9 Heart disease, unspecified
0.000 0.719 0.281
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.719 0.280
I28 Other diseases of pulmonary vessels
0.000 0.720 0.280
I09.9 Rheumatic heart disease, unspecified
0.000 0.720 0.279
I20.9 Angina pectoris, unspecified
0.000 0.720 0.280
I26 Pulmonary embolism
0.000 0.721 0.279
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.726 0.274
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.728 0.271
I42.5 Other restrictive cardiomyopathy
0.000 0.728 0.271
I42.4 Endocardial fibroelastosis
0.000 0.728 0.271
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.728 0.271
I51.4 Myocarditis, unspecified
0.000 0.729 0.271
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.729 0.271
I51.0 Cardiac septal defect, acquired
0.000 0.732 0.268
I31.8 Other specified diseases of pericardium
0.000 0.734 0.266
I31.2 Haemopericardium, not elsewhere classified
0.000 0.734 0.266
I31.1 Chronic constrictive pericarditis
0.000 0.734 0.266
I31.0 Chronic adhesive pericarditis
0.000 0.734 0.266
I30.8 Other forms of acute pericarditis
0.000 0.735 0.264
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.735 0.264
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.737 0.263
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.737 0.263
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.737 0.263
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.737 0.263
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.737 0.263
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.737 0.263
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.737 0.263
I97.0 Postcardiotomy syndrome
0.000 0.737 0.263
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.741 0.259
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.741 0.259
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.741 0.259
I98.0 Cardiovascular syphilis
0.000 0.741 0.259
I51.6 Cardiovascular disease, unspecified
0.000 0.747 0.253
I31.3 Pericardial effusion (noninflammatory)
0.000 0.749 0.251
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.749 0.250
I77 Other disorders of arteries and arterioles
0.000 0.752 0.248
I51.5 Myocardial degeneration
0.000 0.753 0.247
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.753 0.247
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.753 0.247
Z95.0 Presence of cardiac pacemaker
0.000 0.754 0.246
I42.9 Cardiomyopathy, unspecified
0.000 0.755 0.245
I30.1 Infective pericarditis
0.000 0.755 0.244
I49.5 Sick sinus syndrome
0.000 0.756 0.244
I42.6 Alcoholic cardiomyopathy
0.000 0.759 0.240
I49.8 Other specified cardiac arrhythmias
0.001 0.759 0.240
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.763 0.237
I71.3 Abdominal aortic aneurysm, ruptured
0.001 0.764 0.236
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.773 0.227
I78.1 Naevus, nonneoplastic
0.000 0.774 0.226
I46.0 Cardiac arrest with successful resuscitation
0.000 0.776 0.224
I42.2 Other hypertrophic cardiomyopathy
0.000 0.777 0.223
I33.0 Acute and subacute infective endocarditis
0.000 0.778 0.221
I42.8 Other cardiomyopathies
0.000 0.780 0.220
I20.8 Other forms of angina pectoris
0.000 0.780 0.220
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.791 0.209
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.799 0.201
I28.1 Aneurysm of pulmonary artery
0.000 0.799 0.201
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.799 0.201
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.799 0.200
I12.0 Hypertensive renal disease with renal failure
0.000 0.806 0.193
I28.8 Other specified diseases of pulmonary vessels
0.000 0.808 0.192
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.809 0.191
I20.1 Angina pectoris with documented spasm
0.000 0.819 0.181
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.000 0.822 0.178
I77.5 Necrosis of artery
0.000 0.822 0.178
I77.4 Coeliac artery compression syndrome
0.000 0.822 0.178
I77.3 Arterial fibromuscular dysplasia
0.000 0.822 0.178
I77.2 Rupture of artery
0.000 0.822 0.178
I30.9 Acute pericarditis, unspecified
0.001 0.828 0.172
I45 Other conduction disorders
0.000 0.830 0.170
I31.9 Disease of pericardium, unspecified
0.000 0.834 0.166
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.835 0.164
I47.1 Supraventricular tachycardia
0.000 0.838 0.162
I85 Oesophageal varices
0.000 0.839 0.161
I77.1 Stricture of artery
0.000 0.839 0.160
I77.6 Arteritis, unspecified
0.000 0.843 0.157
I77.0 Arteriovenous fistula, acquired
0.000 0.844 0.156
I51.7 Cardiomegaly
0.000 0.847 0.153
I27 Other pulmonary heart diseases
0.000 0.854 0.145
I85.0 Oesophageal varices with bleeding
0.000 0.857 0.143
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.865 0.135
I77.8 Other specified disorders of arteries and arterioles
0.000 0.865 0.135
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.001 0.866 0.133
I88 Nonspecific lymphadenitis
0.000 0.869 0.131
I34 Nonrheumatic mitral valve disorders
0.000 0.869 0.131
I85.9 Oesophageal varices without bleeding
0.000 0.873 0.127
I80 Phlebitis and thrombophlebitis
0.000 0.873 0.127
I45.9 Conduction disorder, unspecified
0.000 0.874 0.126
I86 Varicose veins of other sites
0.000 0.877 0.123
I45.4 Nonspecific intraventricular block
0.000 0.878 0.122
I45.0 Right fascicular block
0.000 0.878 0.122
I45.8 Other specified conduction disorders
0.000 0.882 0.117
I87 Other disorders of veins
0.000 0.884 0.116
I80.1 Phlebitis and thrombophlebitis of femoral vein
0.000 0.887 0.113
I82 Other venous embolism and thrombosis
0.000 0.887 0.113
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.000 0.889 0.111
I45.2 Bifascicular block
0.000 0.891 0.109
I45.5 Other specified heart block
0.000 0.891 0.109
I45.3 Trifascicular block
0.000 0.894 0.106
I27.8 Other specified pulmonary heart diseases
0.000 0.895 0.104
I27.1 Kyphoscoliotic heart disease
0.000 0.895 0.104
I81 Portal vein thrombosis
0.000 0.897 0.103
I86.4 Gastric varices
0.000 0.900 0.100
I45.6 Preexcitation syndrome
0.000 0.900 0.100
I60-I69 Cerebrovascular diseases
0.000 0.902 0.098
I88.9 Nonspecific lymphadenitis, unspecified
0.000 0.903 0.097
I80.8 Phlebitis and thrombophlebitis of other sites
0.000 0.903 0.097
I27.2 Other secondary pulmonary hypertension
0.000 0.904 0.096
I80.9 Phlebitis and thrombophlebitis of unspecified site
0.000 0.905 0.095
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.000 0.906 0.094
I88.8 Other nonspecific lymphadenitis
0.000 0.906 0.094
I88.1 Chronic lymphadenitis, except mesenteric
0.000 0.906 0.094
I88.0 Nonspecific mesenteric lymphadenitis
0.000 0.906 0.094
I34.8 Other nonrheumatic mitral valve disorders
0.000 0.906 0.094
I34.2 Nonrheumatic mitral (valve) stenosis
0.000 0.910 0.090
I87.1 Compression of vein
0.000 0.910 0.090
I86.3 Vulval varices
0.000 0.912 0.088
I86.2 Pelvic varices
0.000 0.912 0.088
I86.0 Sublingual varices
0.000 0.912 0.088
I87.2 Venous insufficiency (chronic) (peripheral)
0.000 0.914 0.086
I89.1 Lymphangitis
0.000 0.914 0.086
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes
0.000 0.915 0.085
I82.9 Embolism and thrombosis of unspecified vein
0.000 0.916 0.084
I87.9 Disorder of vein, unspecified
0.000 0.916 0.083
I87.0 Postphlebitic syndrome
0.000 0.916 0.083
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.000 0.917 0.083
I82.3 Embolism and thrombosis of renal vein
0.000 0.919 0.081
I82.1 Thrombophlebitis migrans
0.000 0.919 0.081
I82.0 Budd-Chiari syndrome
0.000 0.919 0.081
I62 Other nontraumatic intracranial haemorrhage
0.000 0.919 0.081
E10 Insulin-dependent diabetes mellitus
0.000 0.919 0.080
I86.1 Scrotal varices
0.000 0.920 0.080
E10.9 Without complications
0.000 0.920 0.080
I82.8 Embolism and thrombosis of other specified veins
0.000 0.921 0.079
E10.3 With ophthalmic complications
0.000 0.922 0.078
I63 Cerebral infarction
0.000 0.923 0.077
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.000 0.923 0.077
I86.8 Varicose veins of other specified sites
0.000 0.926 0.074
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.000 0.927 0.073
I27.9 Pulmonary heart disease, unspecified
0.001 0.928 0.072
E10.1 With ketoacidosis
0.000 0.928 0.072
C18.7 Sigmoid colon
0.071 0.929 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.000 0.929 0.071
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.000 0.929 0.071
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.000 0.930 0.070
E10.4 With neurological complications
0.000 0.930 0.070
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.000 0.935 0.065
I82.2 Embolism and thrombosis of vena cava
0.000 0.935 0.064
E10.2 With renal complications
0.000 0.938 0.062
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.000 0.938 0.062
I64 Stroke, not specified as haemorrhage or infarction
0.000 0.939 0.061
I27.0 Primary pulmonary hypertension
0.000 0.939 0.060
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified
0.000 0.941 0.059
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.000 0.941 0.059
I62.1 Nontraumatic extradural haemorrhage
0.000 0.942 0.058
E10.8 With unspecified complications
0.000 0.942 0.058
E10.7 With multiple complications
0.000 0.942 0.058
I69 Sequelae of cerebrovascular disease
0.000 0.942 0.058
I87.8 Other specified disorders of veins
0.000 0.942 0.057
E10.6 With other specified complications
0.000 0.944 0.056
I95 Hypotension
0.001 0.944 0.055
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.000 0.944 0.056
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.000 0.944 0.056
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.000 0.944 0.056
E10.5 With peripheral circulatory complications
0.000 0.945 0.055
I45.1 Other and unspecified right bundle-branch block
0.000 0.947 0.053
I20.0 Unstable angina
0.000 0.947 0.053
I63.8 Other cerebral infarction
0.000 0.948 0.052
E10.0 With coma
0.000 0.948 0.052
I51.8 Other ill-defined heart diseases
0.000 0.949 0.051
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.000 0.949 0.051
I66.8 Occlusion and stenosis of other cerebral artery
0.000 0.949 0.051
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.000 0.949 0.051
I66.3 Occlusion and stenosis of cerebellar arteries
0.000 0.949 0.051
I66.2 Occlusion and stenosis of posterior cerebral artery
0.000 0.949 0.051
I66.1 Occlusion and stenosis of anterior cerebral artery
0.000 0.949 0.051
I66.0 Occlusion and stenosis of middle cerebral artery
0.000 0.949 0.051
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.000 0.949 0.051
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.000 0.949 0.051
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.000 0.949 0.051
I68.0 Cerebral amyloid angiopathy
0.000 0.949 0.051
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.000 0.951 0.049
I61 Intracerebral haemorrhage
0.000 0.951 0.049
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.952 0.048
I89.0 Lymphoedema, not elsewhere classified
0.000 0.954 0.045
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.000 0.956 0.043
I69.1 Sequelae of intracerebral haemorrhage
0.000 0.957 0.043
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.000 0.959 0.041
I95.8 Other hypotension
0.001 0.960 0.039
I95.0 Idiopathic hypotension
0.001 0.960 0.039
E10-E14 Diabetes mellitus
0.000 0.960 0.040
K76.0 Fatty (change of) liver, not elsewhere classified
0.000 0.960 0.040
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.000 0.961 0.039
I83 Varicose veins of lower extremities
0.000 0.961 0.039
I34.1 Mitral (valve) prolapse
0.001 0.961 0.038
I69.3 Sequelae of cerebral infarction
0.000 0.962 0.038
C18 Malignant neoplasm of colon
0.038 0.962 0.000
I61.8 Other intracerebral haemorrhage
0.000 0.964 0.036
I61.6 Intracerebral haemorrhage, multiple localised
0.000 0.965 0.035
I61.3 Intracerebral haemorrhage in brain stem
0.000 0.965 0.035
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.000 0.965 0.035
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.000 0.965 0.035
I65.8 Occlusion and stenosis of other precerebral artery
0.000 0.965 0.035
I65.1 Occlusion and stenosis of basilar artery
0.000 0.965 0.035
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.000 0.965 0.034
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.000 0.965 0.034
C71 Malignant neoplasm of brain
0.034 0.966 0.000
I61.4 Intracerebral haemorrhage in cerebellum
0.000 0.966 0.034
E11.5 With peripheral circulatory complications
0.000 0.966 0.034
E11 Non-insulin-dependent diabetes mellitus
0.000 0.966 0.034
I84 Haemorrhoids
0.000 0.966 0.034
I69.0 Sequelae of subarachnoid haemorrhage
0.000 0.968 0.032
C71.9 Brain, unspecified
0.032 0.968 0.000
I67 Other cerebrovascular diseases
0.000 0.968 0.031
I84.5 External haemorrhoids without complication
0.000 0.969 0.031
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.031 0.969 0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.000 0.969 0.031
C71.2 Temporal lobe
0.031 0.969 0.000
C18.6 Descending colon
0.031 0.969 0.000
C71.1 Frontal lobe
0.031 0.969 0.000
C18.2 Ascending colon
0.030 0.970 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.000 0.970 0.030
I65.0 Occlusion and stenosis of vertebral artery
0.000 0.970 0.029
I65.2 Occlusion and stenosis of carotid artery
0.000 0.971 0.029
C18.0 Caecum
0.029 0.971 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.971 0.029
I61.5 Intracerebral haemorrhage, intraventricular
0.000 0.972 0.028
I61.9 Intracerebral haemorrhage, unspecified
0.000 0.972 0.028
E13 Other specified diabetes mellitus
0.000 0.972 0.028
Chapter II Neoplasms
0.028 0.972 0.000
I60 Subarachnoid haemorrhage
0.000 0.972 0.028
C15-C26 Malignant neoplasms of digestive organs
0.028 0.972 0.000
C71.8 Overlapping lesion of brain
0.028 0.972 0.000
C50 Malignant neoplasm of breast
0.028 0.972 0.000
C51-C58 Malignant neoplasms of female genital organs
0.028 0.972 0.000
C50-C50 Malignant neoplasm of breast
0.028 0.972 0.000
I84.7 Unspecified thrombosed haemorrhoids
0.000 0.973 0.027
C18.8 Overlapping lesion of colon
0.027 0.973 0.000
I95.2 Hypotension due to drugs
0.001 0.973 0.026
E11.3 With ophthalmic complications
0.000 0.973 0.027
C50.5 Lower-outer quadrant of breast
0.027 0.973 0.000
D00-D09 In situ neoplasms
0.027 0.973 0.000
I84.0 Internal thrombosed haemorrhoids
0.000 0.973 0.027
E11.8 With unspecified complications
0.000 0.973 0.027
I83.1 Varicose veins of lower extremities with inflammation
0.000 0.973 0.026
C71.3 Parietal lobe
0.026 0.974 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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