TreeWAS – Variant ID: rs6129846

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
K11 Diseases of salivary glands	0.040	0.960	0.000
K11.2 Sialoadenitis	0.040	0.960	0.000
K04 Diseases of pulp and periapical tissues	0.040	0.960	0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws	0.039	0.961	0.000
K13 Other diseases of lip and oral mucosa	0.037	0.963	0.000
K12 Stomatitis and related lesions	0.037	0.963	0.000
K13.0 Diseases of lips	0.037	0.963	0.000
K04.9 Other and unspecified diseases of pulp and periapical tissues	0.036	0.964	0.000
K04.7 Periapical abscess without sinus	0.034	0.966	0.000
K11.8 Other diseases of salivary glands	0.034	0.966	0.000
K12.3 Oral mucositis (ulcerative)	0.034	0.966	0.000
K12.1 Other forms of stomatitis	0.034	0.966	0.000
K04.8 Radicular cyst	0.033	0.967	0.000
K11.5 Sialolithiasis	0.033	0.967	0.000
K00 Disorders of tooth development and eruption	0.033	0.967	0.000
K13.4 Granuloma and granuloma-like lesions of oral mucosa	0.032	0.968	0.000
K06 Other disorders of gingiva and edentulous alveolar ridge	0.032	0.968	0.000
K11.1 Hypertrophy of salivary gland	0.032	0.968	0.000
K04.4 Acute apical periodontitis of pulpal origin	0.031	0.969	0.000
K11.9 Disease of salivary gland, unspecified	0.030	0.970	0.000
K04.5 Chronic apical periodontitis	0.030	0.970	0.000
K10 Other diseases of jaws	0.030	0.970	0.000
K09 Cysts of oral region, not elsewhere classified	0.030	0.970	0.000
K04.0 Pulpitis	0.029	0.970	0.000
K11.7 Disturbances of salivary secretion	0.029	0.971	0.000
K11.4 Fistula of salivary gland	0.029	0.971	0.000
K11.3 Abscess of salivary gland	0.029	0.971	0.000
K11.0 Atrophy of salivary gland	0.029	0.971	0.000
K04.3 Abnormal hard tissue formation in pulp	0.028	0.971	0.000
K04.2 Pulp degeneration	0.028	0.971	0.000
K04.1 Necrosis of pulp	0.028	0.971	0.000
K13.6 Irritative hyperplasia of oral mucosa	0.028	0.971	0.000
K12.0 Recurrent oral aphthae	0.028	0.971	0.000
K03 Other diseases of hard tissues of teeth	0.028	0.972	0.000
K00.6 Disturbances in tooth eruption	0.028	0.972	0.000
D23.1 Skin of eyelid, including canthus	0.000	0.973	0.027
K13.2 Leukoplakia and other disturbances of oral epithelium, including tongue	0.027	0.973	0.000
K13.5 Oral submucous fibrosis	0.027	0.973	0.000
K13.3 Hairy leukoplakia	0.027	0.973	0.000
K13.1 Cheek and lip biting	0.027	0.973	0.000
D23 Other benign neoplasms of skin	0.000	0.973	0.027
K05 Gingivitis and periodontal diseases	0.026	0.974	0.000
K01 Embedded and impacted teeth	0.026	0.974	0.000
K06.9 Disorder of gingiva and edentulous alveolar ridge, unspecified	0.026	0.974	0.000
K04.6 Periapical abscess with sinus	0.026	0.974	0.000
K07 Dentofacial anomalies [including malocclusion]	0.025	0.975	0.000
K09.1 Developmental (nonodontogenic) cysts of oral region	0.025	0.975	0.000
K06.8 Other specified disorders of gingiva and edentulous alveolar ridge	0.025	0.975	0.000
K10.2 Inflammatory conditions of jaws	0.024	0.976	0.000
K09.0 Developmental odontogenic cysts	0.024	0.976	0.000
D23.7 Skin of lower limb, including hip	0.000	0.976	0.024
D23.3 Skin of other and unspecified parts of face	0.000	0.976	0.024
K00.9 Disorder of tooth development, unspecified	0.024	0.976	0.000
K00.8 Other disorders of tooth development	0.024	0.976	0.000
K00.7 Teething syndrome	0.024	0.976	0.000
K00.5 Hereditary disturbances in tooth structure, not elsewhere classified	0.024	0.976	0.000
K00.4 Disturbances in tooth formation	0.024	0.976	0.000
K00.3 Mottled teeth	0.024	0.976	0.000
K00.2 Abnormalities of size and form of teeth	0.024	0.976	0.000
K00.1 Supernumerary teeth	0.024	0.976	0.000
K00.0 Anodontia	0.024	0.976	0.000
D23.5 Skin of trunk	0.000	0.977	0.023
K06.2 Gingival and edentulous alveolar ridge lesions associated with trauma	0.023	0.977	0.000
K06.1 Gingival enlargement	0.023	0.977	0.000
K06.0 Gingival recession	0.023	0.977	0.000
K10.0 Developmental disorders of jaws	0.023	0.977	0.000
D23.0 Skin of lip	0.000	0.977	0.022
K11.6 Mucocele of salivary gland	0.021	0.978	0.000
K10.9 Disease of jaws, unspecified	0.021	0.978	0.000
K10.3 Alveolitis of jaws	0.021	0.978	0.000
K10.1 Giant cell granuloma, central	0.021	0.978	0.000
K09.9 Cyst of oral region, unspecified	0.021	0.978	0.000
D23.4 Skin of scalp and neck	0.000	0.979	0.021
K03.9 Disease of hard tissues of teeth, unspecified	0.020	0.979	0.000
K03.8 Other specified diseases of hard tissues of teeth	0.020	0.979	0.000
K03.7 Posteruptive colour changes of dental hard tissues	0.020	0.979	0.000
K03.6 Deposits [accretions] on teeth	0.020	0.979	0.000
K03.5 Ankylosis of teeth	0.020	0.979	0.000
K03.4 Hypercementosis	0.020	0.979	0.000
K03.3 Pathological resorption of teeth	0.020	0.979	0.000
K03.2 Erosion of teeth	0.020	0.979	0.000
K03.1 Abrasion of teeth	0.020	0.979	0.000
K03.0 Excessive attrition of teeth	0.020	0.979	0.000
K05.6 Periodontal disease, unspecified	0.020	0.980	0.000
K08 Other disorders of teeth and supporting structures	0.020	0.980	0.000
K07.4 Malocclusion, unspecified	0.020	0.980	0.000
D23.9 Skin, unspecified	0.000	0.980	0.020
K07.1 Anomalies of jaw-cranial base relationship	0.020	0.980	0.000
K13.29 Other disturbances of oral epithelium, including tongue	0.019	0.980	0.000
K05.1 Chronic gingivitis	0.019	0.981	0.000
K05.2 Acute periodontitis	0.019	0.981	0.000
K05.5 Other periodontal diseases	0.019	0.981	0.000
K05.4 Periodontosis	0.019	0.981	0.000
K05.0 Acute gingivitis	0.019	0.981	0.000
D23.2 Skin of ear and external auricular canal	0.000	0.981	0.019
K01.1 Impacted teeth	0.018	0.982	0.000
K07.9 Dentofacial anomaly, unspecified	0.018	0.982	0.000
K07.8 Other dentofacial anomalies	0.018	0.982	0.000
K07.5 Dentofacial functional abnormalities	0.018	0.982	0.000
K07.2 Anomalies of dental arch relationship	0.018	0.982	0.000
K07.0 Major anomalies of jaw size	0.018	0.982	0.000
K08.2 Atrophy of edentulous alveolar ridge	0.018	0.982	0.000
K09.2 Other cysts of jaw	0.018	0.982	0.000
K09.8 Other cysts of oral region, not elsewhere classified	0.017	0.982	0.000
R50.9 Fever, unspecified	0.017	0.983	0.000
K01.0 Embedded teeth	0.017	0.983	0.000
K02 Dental caries	0.017	0.983	0.000
K10.8 Other specified diseases of jaws	0.016	0.984	0.000
K12.2 Cellulitis and abscess of mouth	0.016	0.984	0.000
D23.6 Skin of upper limb, including shoulder	0.000	0.984	0.016
K08.1 Loss of teeth due to accident, extraction or local periodontal disease	0.015	0.985	0.000
K07.3 Anomalies of tooth position	0.015	0.985	0.000
K08.0 Exfoliation of teeth due to systemic causes	0.015	0.985	0.000
K14 Diseases of tongue	0.014	0.986	0.000
K05.22 Aggressive periodontitis, generalized	0.014	0.986	0.000
K05.3 Chronic periodontitis	0.014	0.986	0.000
K07.6 Temporomandibular joint disorders	0.013	0.986	0.000
K08.8 Other specified disorders of teeth and supporting structures	0.014	0.986	0.000
K02.5 Caries with pulp exposure	0.012	0.988	0.000
K02.4 Odontoclasia	0.012	0.988	0.000
K02.3 Arrested dental caries	0.012	0.988	0.000
K02.2 Caries of cementum	0.012	0.988	0.000
K02.1 Caries of dentin	0.012	0.988	0.000
K02.0 Caries limited to enamel	0.012	0.988	0.000
N73.6 Female pelvic peritoneal adhesions	0.011	0.989	0.000
K13.7 Other and unspecified lesions of oral mucosa	0.011	0.989	0.000
K08.9 Disorder of teeth and supporting structures, unspecified	0.010	0.989	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.011	0.989	0.000
K14.6 Glossodynia	0.010	0.989	0.000
K14.5 Plicated tongue	0.010	0.989	0.000
K14.4 Atrophy of tongue papillae	0.010	0.989	0.000
K14.3 Hypertrophy of tongue papillae	0.010	0.989	0.000
K14.2 Median rhomboid glossitis	0.010	0.989	0.000
K14.1 Geographic tongue	0.010	0.989	0.000
K02.8 Other dental caries	0.009	0.991	0.000
K14.0 Glossitis	0.009	0.991	0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.009	0.991	0.000
I71 Aortic aneurysm and dissection	0.008	0.992	0.000
K14.9 Disease of tongue, unspecified	0.007	0.993	0.000
K14.8 Other diseases of tongue	0.007	0.993	0.000
K02.9 Dental caries, unspecified	0.006	0.994	0.000
I71.8 Aortic aneurysm of unspecified site, ruptured	0.006	0.994	0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.006	0.994	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.006	0.994	0.000
I71.1 Thoracic aortic aneurysm, ruptured	0.006	0.994	0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified	0.000	0.994	0.006
N73 Other female pelvic inflammatory diseases	0.006	0.994	0.000
R50 Fever of unknown origin	0.005	0.995	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.005	0.995	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.005	0.995	0.000
D18.0 Haemangioma, any site	0.000	0.995	0.005
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection	0.000	0.995	0.005
I71.0 Dissection of aorta [any part]	0.005	0.995	0.000
N73.9 Female pelvic inflammatory disease, unspecified	0.005	0.995	0.000
J44 Other chronic obstructive pulmonary disease	0.000	0.995	0.005
R39.1 Other difficulties with micturition	0.000	0.996	0.004
N73.8 Other specified female pelvic inflammatory diseases	0.004	0.996	0.000
N73.5 Female pelvic peritonitis, unspecified	0.004	0.996	0.000
N73.4 Female chronic pelvic peritonitis	0.004	0.996	0.000
N73.3 Female acute pelvic peritonitis	0.004	0.996	0.000
N73.2 Unspecified parametritis and pelvic cellulitis	0.004	0.996	0.000
N73.1 Chronic parametritis and pelvic cellulitis	0.004	0.996	0.000
N73.0 Acute parametritis and pelvic cellulitis	0.004	0.996	0.000
Z93.2 Ileostomy status	0.004	0.996	0.000
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.004	0.996	0.000
R50.2 Drug-induced fever	0.004	0.996	0.000
R50.1 Persistent fever	0.004	0.996	0.000
J44.9 Chronic obstructive pulmonary disease, unspecified	0.000	0.996	0.004
M23.80 Other internal derangements of knee (Multiple sites)	0.004	0.996	0.000
I50.9 Heart failure, unspecified	0.004	0.996	0.000
R50.8 Other specified fever	0.003	0.996	0.000
M23.8 Other internal derangements of knee	0.004	0.996	0.000
T93.2 Sequelae of other fractures of lower limb	0.003	0.997	0.000
J33.9 Nasal polyp, unspecified	0.000	0.997	0.003
R50.0 Fever with chills	0.003	0.997	0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)	0.003	0.997	0.000
D68.2 Hereditary deficiency of other clotting factors	0.003	0.997	0.000
D68 Other coagulation defects	0.003	0.997	0.000
D68.0 Von Willebrand's disease	0.003	0.997	0.000
D68.8 Other specified coagulation defects	0.003	0.997	0.000
K08.3 Retained dental root	0.003	0.997	0.000
S42.30 Fracture of shaft of humerus (closed)	0.003	0.997	0.000
J44.8 Other specified chronic obstructive pulmonary disease	0.000	0.997	0.003
S62.60 Fracture of other finger (closed)	0.000	0.997	0.003
M23.87 Other internal derangements of knee (Capsular ligament)	0.003	0.997	0.000
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.003	0.997	0.000
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.003	0.997	0.000
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.003	0.997	0.000
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.003	0.997	0.000
K76.8 Other specified diseases of liver	0.003	0.997	0.000
D68.5 Primary Thrombophilia	0.003	0.997	0.000
S42.40 Fracture of lower end of humerus (closed)	0.003	0.997	0.000
D68.9 Coagulation defect, unspecified	0.003	0.997	0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.003	0.997	0.000
Y40.8 Other systemic antibiotics	0.003	0.997	0.000
D68.6 Other Thrombophilia	0.002	0.997	0.000
D68.4 Acquired coagulation factor deficiency	0.002	0.997	0.000
D68.1 Hereditary factor XI deficiency	0.002	0.997	0.000
T93 Sequelae of injuries of lower limb	0.002	0.998	0.000
K41.9 Unilateral or unspecified femoral hernia, without obstruction or gangrene	0.000	0.998	0.002
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified	0.000	0.998	0.002
Q51.3 Bicornate uterus	0.002	0.998	0.000
D18 Haemangioma and lymphangioma, any site	0.000	0.998	0.002
D41.4 Bladder	0.000	0.998	0.002
S42.3 Fracture of shaft of humerus	0.002	0.998	0.000
V18.0 Driver injured in nontraffic accident	0.000	0.998	0.002
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess	0.002	0.998	0.000
T93.8 Sequelae of other specified injuries of lower limb	0.002	0.998	0.000
T93.1 Sequelae of fracture of femur	0.002	0.998	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.002	0.998	0.000
S62.6 Fracture of other finger	0.000	0.998	0.002
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.002	0.998	0.000
I49.0 Ventricular fibrillation and flutter	0.002	0.998	0.000
I50.0 Congestive heart failure	0.002	0.998	0.000
S42.4 Fracture of lower end of humerus	0.002	0.998	0.000
I50 Heart failure	0.002	0.998	0.000
S62.50 Fracture of thumb (closed)	0.000	0.998	0.002
Y40 Systemic antibiotics	0.002	0.998	0.000
T93.9 Sequelae of unspecified injury of lower limb	0.002	0.998	0.000
I42.0 Dilated cardiomyopathy	0.002	0.998	0.000
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb	0.002	0.998	0.000
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.002	0.998	0.000
T93.4 Sequelae of injury of nerve of lower limb	0.002	0.998	0.000
T93.0 Sequelae of open wound of lower limb	0.002	0.998	0.000
D18.1 Lymphangioma, any site	0.000	0.998	0.002
H61.2 Impacted cerumen	0.002	0.998	0.000
Y40.3 Macrolides	0.002	0.998	0.000
Z93.4 Other artificial openings of gastro-intestinal tract status	0.002	0.998	0.000
S62.61 Fracture of other finger (open)	0.000	0.998	0.002
Z93 Artificial opening status	0.002	0.998	0.000
S42.31 Fracture of shaft of humerus (open)	0.002	0.998	0.000
Q51 Congenital malformations of uterus and cervix	0.002	0.998	0.000
Y44.2 Anticoagulants	0.002	0.998	0.000
S42.70 Multiple fractures of clavicle, scapula and humerus (closed)	0.002	0.998	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.002	0.998	0.000
Z93.9 Artificial opening status, unspecified	0.002	0.998	0.000
S42.41 Fracture of lower end of humerus (open)	0.002	0.998	0.000
N99.4 Postprocedural pelvic peritoneal adhesions	0.000	0.998	0.002
V18.2 Unspecified pedal cyclist injured in nontraffic accident	0.000	0.998	0.002
S42.7 Multiple fractures of clavicle, scapula and humerus	0.002	0.998	0.000
Y40.7 Antifungal antibiotics, systemically used	0.002	0.998	0.000
Y40.6 Rifamycins	0.002	0.998	0.000
Y40.5 Aminoglycosides	0.002	0.998	0.000
Y40.4 Tetracyclines	0.002	0.998	0.000
Y40.2 Chloramphenicol group	0.002	0.998	0.000
S62.5 Fracture of thumb	0.000	0.998	0.002
S42 Fracture of shoulder and upper arm	0.002	0.998	0.000
V18 Pedal cyclist injured in noncollision transport accident	0.000	0.998	0.002
Y51 Drugs primarily affecting the autonomic nervous system	0.002	0.998	0.000
Y44 Agents primarily affecting blood constituents	0.002	0.998	0.000
L98.9 Disorder of skin and subcutaneous tissue, unspecified	0.002	0.998	0.000
N50.1 Vascular disorders of male genital organs	0.002	0.998	0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified	0.002	0.998	0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified	0.002	0.998	0.000
M54.57 Low back pain (Lumbosacral region)	0.000	0.998	0.002
Q51.2 Other doubling of uterus	0.002	0.998	0.000
H74.0 Tympanosclerosis	0.002	0.998	0.000
Z93.8 Other artificial opening status	0.002	0.998	0.000
Z93.1 Gastrostomy status	0.002	0.998	0.000
Q51.9 Congenital malformation of uterus and cervix, unspecified	0.001	0.998	0.000
Q51.8 Other congenital malformations of uterus and cervix	0.001	0.998	0.000
Q51.7 Congenital fistulae between uterus and digestive and urinary tracts	0.001	0.998	0.000
Q51.6 Embryonic cyst of cervix	0.001	0.998	0.000
Q51.5 Agenesis and aplasia of cervix	0.001	0.998	0.000
Q51.4 Unicornate uterus	0.001	0.998	0.000
Q51.1 Doubling of uterus with doubling of cervix and vagina	0.001	0.998	0.000
Q51.0 Agenesis and aplasia of uterus	0.001	0.998	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.002	0.998	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.002	0.998	0.000
H74.4 Polyp of middle ear	0.002	0.998	0.000
K76.0 Fatty (change of) liver, not elsewhere classified	0.002	0.998	0.000
N99.0 Postprocedural renal failure	0.000	0.998	0.002
T93.3 Sequelae of dislocation, sprain and strain of lower limb	0.001	0.998	0.000
Y40.9 Systemic antibiotic, unspecified	0.002	0.998	0.000
R44.3 Hallucinations, unspecified	0.000	0.998	0.002
Y40.0 Penicillins	0.002	0.998	0.000
Z93.0 Tracheostomy status	0.002	0.998	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.002	0.998	0.000
C78.0 Secondary malignant neoplasm of lung	0.000	0.998	0.002
H74.3 Other acquired abnormalities of ear ossicles	0.002	0.998	0.000
S42.71 Multiple fractures of clavicle, scapula and humerus (open)	0.001	0.998	0.000
N99.8 Other postprocedural disorders of genito-urinary system	0.000	0.998	0.002
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.001	0.998	0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified	0.000	0.998	0.002
Z93.6 Other artificial openings of urinary tract status	0.002	0.998	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.001	0.998	0.000
S62.51 Fracture of thumb (open)	0.000	0.998	0.001
S42.9 Fracture of shoulder girdle, part unspecified	0.001	0.998	0.000
S42.8 Fracture of other parts of shoulder and upper arm	0.001	0.998	0.000
T92.9 Sequelae of unspecified injury of upper limb	0.001	0.998	0.000
V18.9 Unspecified pedal cyclist injured in traffic accident	0.000	0.998	0.001
V18.4 Driver injured in traffic accident	0.000	0.998	0.001
V18.5 Passenger injured in traffic accident	0.000	0.998	0.001
V18.3 Person injured while boarding or alighting	0.000	0.998	0.001
V18.1 Passenger injured in nontraffic accident	0.000	0.998	0.001
Y44.9 Other and unspecified agents affecting blood constituents	0.001	0.998	0.000
Y44.7 Plasma substitutes	0.001	0.998	0.000
Y44.6 Natural blood and blood products	0.001	0.998	0.000
Y44.5 Thrombolytic drugs	0.001	0.998	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.001	0.998	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.001	0.998	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.001	0.998	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.001	0.998	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.001	0.998	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.001	0.998	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.001	0.998	0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.001	0.998	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.001	0.998	0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.001	0.998	0.000
Y51.1 Other parasympathomimetics [cholinergics]	0.001	0.998	0.000
Y51.0 Anticholinesterase agents	0.001	0.998	0.000
H74 Other disorders of middle ear and mastoid	0.002	0.998	0.000
Q54.9 Hypospadias, unspecified	0.001	0.998	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.002	0.998	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.002	0.998	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.001	0.998	0.000
Q54 Hypospadias	0.001	0.998	0.000
I49.8 Other specified cardiac arrhythmias	0.001	0.998	0.000
N99.3 Prolapse of vaginal vault after hysterectomy	0.000	0.998	0.001
Y43.4 Immunosuppressive agents	0.001	0.998	0.000
Z95.0 Presence of cardiac pacemaker	0.002	0.998	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.001	0.998	0.000
Z93.5 Cystostomy status	0.001	0.998	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.001	0.999	0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb	0.001	0.999	0.000
S62 Fracture at wrist and hand level	0.000	0.999	0.001
H74.8 Other specified disorders of middle ear and mastoid	0.001	0.999	0.000
R40.2 Coma, unspecified	0.001	0.999	0.000
Y59 Other and unspecified vaccines and biological substances	0.001	0.999	0.000
Y58 Bacterial vaccines	0.001	0.999	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.001	0.999	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.001	0.999	0.000
Y48 Anaesthetics and therapeutic gases	0.001	0.999	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.001	0.999	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.001	0.999	0.000
Y43 Primarily systemic agents	0.001	0.999	0.000
Q50-Q56 Congenital malformations of genital organs	0.001	0.999	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.001	0.999	0.000
T92 Sequelae of injuries of upper limb	0.001	0.999	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.001	0.999	0.000
Q54.0 Hypospadias, balanic	0.001	0.999	0.000
S62.0 Fracture of navicular [scaphoid] bone of hand	0.000	0.999	0.001
Y42.7 Androgens and anabolic congeners	0.001	0.999	0.000
Y56.9 Topical agent, unspecified	0.001	0.999	0.000
Y56.8 Other topical agents	0.001	0.999	0.000
Y56.7 Dental drugs, topically applied	0.001	0.999	0.000
Y56.6 Otorhinolaryngological drugs and preparations	0.001	0.999	0.000
Y56.5 Ophthalmological drugs and preparations	0.001	0.999	0.000
Y56.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.001	0.999	0.000
Y56.3 Emollients, demulcents and protectants	0.001	0.999	0.000
Y56.2 Local astringents and local detergents	0.001	0.999	0.000
Y56.1 Antipruritics	0.001	0.999	0.000
N99.9 Postprocedural disorder of genito-urinary system, unspecified	0.000	0.999	0.001
N99.2 Postprocedural adhesions of vagina	0.000	0.999	0.001
R10.2 Pelvic and perineal pain	0.001	0.999	0.000
S42.1 Fracture of scapula	0.001	0.999	0.000
L90.5 Scar conditions and fibrosis of skin	0.001	0.999	0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.001	0.999	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.001	0.999	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.001	0.999	0.000
S42.81 Fracture of other parts of shoulder and upper arm (open)	0.001	0.999	0.000
S42.80 Fracture of other parts of shoulder and upper arm (closed)	0.001	0.999	0.000
S42.91 Fracture of shoulder girdle, part unspecified (open)	0.001	0.999	0.000
S42.90 Fracture of shoulder girdle, part unspecified (closed)	0.001	0.999	0.000
S62.00 Fracture of navicular [scaphoid] bone of hand (closed)	0.000	0.999	0.001
V18.49 Pedal cyclist injured in noncollision transport accident; driver injured in traffic accident ; during unspecified activity	0.000	0.999	0.001
V18.99 Pedal cyclist injured in noncollision transport accident; unspecified pedal cyclist injured in traffic accident; during unspecified activity	0.000	0.999	0.001
D32.0 Cerebral meninges	0.001	0.999	0.000
H74.9 Disorder of middle ear and mastoid, unspecified	0.001	0.999	0.000
H74.2 Discontinuity and dislocation of ear ossicles	0.001	0.999	0.000
H74.1 Adhesive middle ear disease	0.001	0.999	0.000
I49.3 Ventricular premature depolarisation	0.001	0.999	0.000
N45.0 Orchitis, epididymitis and epididymo-orchitis with abscess	0.001	0.999	0.000
Q87.4 Marfan's syndrome	0.001	0.999	0.000
S61.1 Open wound of finger(s) with damage to nail	0.000	0.999	0.001
T45.0 Antiallergic and antiemetic drugs	0.001	0.999	0.000
Y42.9 Other and unspecified hormone antagonists	0.001	0.999	0.000
Y42.4 Oral contraceptives	0.001	0.999	0.000
Y42.2 Antithyroid drugs	0.001	0.999	0.000
Y42.1 Thyroid hormones and substitutes	0.001	0.999	0.000
D67 Hereditary factor IX deficiency	0.001	0.999	0.000
D66 Hereditary factor VIII deficiency	0.001	0.999	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.001	0.999	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.001	0.999	0.000
M06.9 Rheumatoid arthritis, unspecified	0.001	0.999	0.000
Q54.8 Other hypospadias	0.001	0.999	0.000
Q54.4 Congenital chordee	0.001	0.999	0.000
Q54.3 Hypospadias, perineal	0.001	0.999	0.000
Q54.2 Hypospadias, penoscrotal	0.001	0.999	0.000
Q54.1 Hypospadias, penile	0.001	0.999	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.001	0.999	0.000
Z49.0 Preparatory care for dialysis	0.000	0.999	0.001
J33 Nasal polyp	0.000	0.999	0.001
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments	0.001	0.999	0.000
M06.4 Inflammatory polyarthropathy	0.001	0.999	0.000
Q63.0 Accessory kidney	0.000	0.999	0.001
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.001	0.999	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.001	0.999	0.000
Y53.7 Emetics	0.001	0.999	0.000
Y53.6 Antidiarrhoeal drugs	0.001	0.999	0.000
Y53.5 Digestants	0.001	0.999	0.000
Y53.4 Other laxatives	0.001	0.999	0.000
Y53.3 Saline and osmotic laxatives	0.001	0.999	0.000
Y53.2 Stimulant laxatives	0.001	0.999	0.000
Y53.0 Histamine H2-receptor antagonists	0.001	0.999	0.000
Q53 Undescended testicle	0.001	0.999	0.000
I50.1 Left ventricular failure	0.001	0.999	0.000
S62.7 Multiple fractures of fingers	0.000	0.999	0.001
S62.1 Fracture of other carpal bone(s)	0.000	0.999	0.001
Y49.2 Other and unspecified antidepressants	0.001	0.999	0.000
Y54.4 Loop [high-ceiling] diuretics	0.001	0.999	0.000
M94.86 Other specified disorders of cartilage (Lower leg)	0.001	0.999	0.000
G00.9 Bacterial meningitis, unspecified	0.001	0.999	0.000
K92.1 Melaena	0.001	0.999	0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid	0.001	0.999	0.000
S62.4 Multiple fractures of metacarpal bones	0.000	0.999	0.001
Y43.9 Primarily systemic agent, unspecified	0.001	0.999	0.000
Y43.8 Other primarily systemic agents, not elsewhere classified	0.001	0.999	0.000
Y43.6 Enzymes, not elsewhere classified	0.001	0.999	0.000
Y43.5 Acidifying and alkalising agents	0.001	0.999	0.000
Y43.2 Antineoplastic natural products	0.001	0.999	0.000
Y46.8 Antispasticity drugs	0.001	0.999	0.000
Y46.7 Anti-Parkinsonism drugs	0.001	0.999	0.000
Y46.6 Other and unspecified antiepileptics	0.001	0.999	0.000
Y46.5 Valproic acid	0.001	0.999	0.000
Y46.4 Iminostilbenes	0.001	0.999	0.000
Y46.3 Deoxybarbiturates	0.001	0.999	0.000
Y46.2 Hydantoin derivatives	0.001	0.999	0.000
Y46.1 Oxazolidinediones	0.001	0.999	0.000
Y46.0 Succinimides	0.001	0.999	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.001	0.999	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.001	0.999	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.001	0.999	0.000
Y47.4 Bromine compounds	0.001	0.999	0.000
Y47.3 Paraldehyde	0.001	0.999	0.000
Y47.2 Chloral derivatives	0.001	0.999	0.000
Y47.1 Benzodiazepines	0.001	0.999	0.000
Y47.0 Barbiturates, not elsewhere classified	0.001	0.999	0.000
Y48.5 Therapeutic gases	0.001	0.999	0.000
Y48.4 Anaesthetic, unspecified	0.001	0.999	0.000
Y48.3 Local anaesthetics	0.001	0.999	0.000
Y48.2 Other and unspecified general anaesthetics	0.001	0.999	0.000
Y48.1 Parenteral anaesthetics	0.001	0.999	0.000
Y48.0 Inhaled anaesthetics	0.001	0.999	0.000
Y50.9 Central nervous system stimulant, unspecified	0.001	0.999	0.000
Y50.8 Other central nervous system stimulants	0.001	0.999	0.000
Y50.2 Methylxanthines, not elsewhere classified	0.001	0.999	0.000
Y50.1 Opioid receptor antagonists	0.001	0.999	0.000
Y50.0 Analeptics	0.001	0.999	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.001	0.999	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.001	0.999	0.000
Y55.5 Anticommon cold drugs	0.001	0.999	0.000
Y55.4 Expectorants	0.001	0.999	0.000
Y55.3 Antitussives	0.001	0.999	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.001	0.999	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.001	0.999	0.000
Y55.0 Oxytocic drugs	0.001	0.999	0.000
Y58.9 Other and unspecified bacterial vaccines	0.001	0.999	0.000
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.001	0.999	0.000
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.001	0.999	0.000
Y58.5 Diphtheria vaccine	0.001	0.999	0.000
Y58.4 Tetanus vaccine	0.001	0.999	0.000
Y58.3 Plague vaccine	0.001	0.999	0.000
Y58.2 Cholera vaccine	0.001	0.999	0.000
Y58.1 Typhoid and paratyphoid vaccine	0.001	0.999	0.000
Y58.0 BCG vaccine	0.001	0.999	0.000
Y59.9 Vaccine or biological substance, unspecified	0.001	0.999	0.000
Y59.8 Other specified vaccines and biological substances	0.001	0.999	0.000
Y59.3 Immunoglobulin	0.001	0.999	0.000
Y59.2 Protozoal vaccines	0.001	0.999	0.000
Y59.1 Rickettsial vaccines	0.001	0.999	0.000
Y59.0 Viral vaccines	0.001	0.999	0.000
Q56 Indeterminate sex and pseudohermaphroditism	0.001	0.999	0.000
Q55 Other congenital malformations of male genital organs	0.001	0.999	0.000
Q52 Other congenital malformations of female genitalia	0.001	0.999	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.001	0.999	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.001	0.999	0.000
M66.06 Rupture of popliteal cyst-Lower leg	0.001	0.999	0.000
N99.1 Postprocedural urethral stricture	0.000	0.999	0.001
S90.9 Superficial injury of ankle and foot, unspecified	0.001	0.999	0.000
T92.8 Sequelae of other specified injuries of upper limb	0.001	0.999	0.000
T92.6 Sequelae of crushing injury and traumatic amputation of upper limb	0.001	0.999	0.000
T92.4 Sequelae of injury of nerve of upper limb	0.001	0.999	0.000
T92.0 Sequelae of open wound of upper limb	0.001	0.999	0.000
Y49.9 Psychotropic drug, unspecified	0.001	0.999	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.001	0.999	0.000
Y49.7 Psychostimulants with abuse potential	0.001	0.999	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.001	0.999	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.001	0.999	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.001	0.999	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.001	0.999	0.000
Y49.0 Tricyclic and tetracyclic antidepressants	0.001	0.999	0.000
K76 Other diseases of liver	0.001	0.999	0.000
N45 Orchitis and epididymitis	0.001	0.999	0.000
S42.11 Fracture of scapula (open)	0.001	0.999	0.000
S62.01 Fracture of navicular [scaphoid] bone of hand (open)	0.000	0.999	0.001
C90.0 Multiple myeloma	0.001	0.999	0.000
N99.5 Malfunction of external stoma of urinary tract	0.000	0.999	0.001
O68.9 Labour and delivery complicated by foetal stress, unspecified	0.001	0.999	0.000
Q50.4 Embryonic cyst of Fallopian tube	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations