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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs619865
log Bayes Factor = 38.3242
Chromosome 20   position 33,867,697  (GRCh37) Explore rs619865 on Ensembl!
Variant rs619865 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
C44 Other malignant neoplasms of skin
1.000 0.000 0.000
C43 Malignant melanoma of skin
1.000 0.000 0.000
M20 Acquired deformities of fingers and toes
1.000 0.000 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
1.000 0.000 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
1.000 0.000 0.000
C44.6 Skin of upper limb, including shoulder
1.000 0.000 0.000
C44.3 Skin of other and unspecified parts of face
1.000 0.000 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
M20.1 Hallux valgus (acquired)
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
C44.5 Skin of trunk
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
L57.0 Actinic keratosis
1.000 0.000 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
1.000 0.000 0.000
L57 Skin changes due to chronic exposure to nonionising radiation
1.000 0.000 0.000
C44.4 Skin of scalp and neck
1.000 0.000 0.000
C43.5 Malignant melanoma of trunk
0.999 0.001 0.000
L90 Atrophic disorders of skin
0.999 0.001 0.000
L90.5 Scar conditions and fibrosis of skin
0.999 0.001 0.000
M20.4 Other hammer toe(s) (acquired)
0.999 0.001 0.000
L81 Other disorders of pigmentation
0.998 0.002 0.000
Z85.8 Personal history of malignant neoplasms of other organs and systems
0.998 0.002 0.000
C44.1 Skin of eyelid, including canthus
0.997 0.003 0.000
L60-L75 Disorders of skin appendages
0.996 0.004 0.000
L81.4 Other melanin hyperpigmentation
0.996 0.004 0.000
L72.1 Trichilemmal cyst
0.996 0.004 0.000
L72 Follicular cysts of skin and subcutaneous tissue
0.996 0.004 0.000
M23 Internal derangement of knee
0.994 0.006 0.000
M80-M85 Disorders of bone density and structure
0.993 0.007 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.991 0.009 0.000
D00-D09 In situ neoplasms
0.990 0.010 0.000
D03 Melanoma in situ
0.989 0.011 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.988 0.012 0.000
C43.6 Malignant melanoma of upper limb, including shoulder
0.988 0.012 0.000
# Top node
0.987 0.013 0.000
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)
0.985 0.015 0.000
C44.7 Skin of lower limb, including hip
0.983 0.017 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.982 0.018 0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.977 0.023 0.000
D03.5 Melanoma in situ of trunk
0.973 0.027 0.000
C44.2 Skin of ear and external auricular canal
0.965 0.035 0.000
C71 Malignant neoplasm of brain
0.964 0.036 0.000
M40-M43 Deforming dorsopathies
0.960 0.040 0.000
M84 Disorders of continuity of bone
0.960 0.040 0.000
M80 Osteoporosis with pathological fracture
0.955 0.045 0.000
D46 Myelodysplastic syndromes
0.952 0.048 0.000
L85 Other epidermal thickening
0.946 0.054 0.000
Chapter VII Diseases of the eye and adnexa
0.945 0.055 0.000
M20.0 Deformity of finger(s)
0.941 0.059 0.000
L89 Decubitus ulcer
0.940 0.060 0.000
C64-C68 Malignant neoplasms of urinary tract
0.937 0.063 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.933 0.067 0.000
C71.9 Brain, unspecified
0.929 0.071 0.000
H53-H54 Visual disturbances and blindness
0.919 0.081 0.000
D03.6 Melanoma in situ of upper limb, including shoulder
0.918 0.082 0.000
H53 Visual disturbances
0.913 0.087 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.911 0.089 0.000
C43.4 Malignant melanoma of scalp and neck
0.909 0.091 0.000
M43 Other deforming dorsopathies
0.904 0.096 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.903 0.097 0.000
Chapter XX External causes of morbidity and mortality
0.900 0.100 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.895 0.105 0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)
0.890 0.110 0.000
C43.3 Malignant melanoma of other and unspecified parts of face
0.889 0.111 0.000
D03.3 Melanoma in situ of other and unspecified parts of face
0.889 0.111 0.000
D46.9 Myelodysplastic syndrome, unspecified
0.884 0.116 0.000
L81.8 Other specified disorders of pigmentation
0.884 0.116 0.000
L85.8 Other specified epidermal thickening
0.880 0.120 0.000
L89.1 Stage II decubitus ulcer
0.878 0.122 0.000
H53.8 Other visual disturbances
0.877 0.123 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.875 0.125 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.874 0.126 0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.873 0.127 0.000
C44.0 Skin of lip
0.870 0.130 0.000
M20.2 Hallux rigidus
0.869 0.131 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.865 0.134 0.000
H53.4 Visual field defects
0.865 0.135 0.000
M45-M49 Spondylopathies
0.865 0.135 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.864 0.136 0.000
D45 Polycythaemia vera
0.857 0.143 0.000
M60-M63 Disorders of muscles
0.857 0.143 0.000
M43.1 Spondylolisthesis
0.846 0.154 0.000
M86-M90 Other osteopathies
0.844 0.156 0.000
L89.0 Stage I decubitus ulcer and pressure area
0.834 0.166 0.000
C71.0 Cerebrum, except lobes and ventricles
0.829 0.171 0.000
Y52 Agents primarily affecting the cardiovascular system
0.828 0.172 0.000
H30-H36 Disorders of choroid and retina
0.828 0.172 0.000
M00-M03 Infectious arthropathies
0.827 0.173 0.000
M91-M94 Chondropathies
0.827 0.173 0.000
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)
0.827 0.173 0.000
M23.8 Other internal derangements of knee
0.821 0.179 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.817 0.183 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.816 0.184 0.000
D03.4 Melanoma in situ of scalp and neck
0.815 0.185 0.000
H34 Retinal vascular occlusions
0.811 0.189 0.000
H02 Other disorders of eyelid
0.811 0.189 0.000
H04 Disorders of lachrymal system
0.810 0.190 0.000
C43.1 Malignant melanoma of eyelid, including canthus
0.805 0.195 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.805 0.195 0.000
L70 Acne
0.804 0.196 0.000
C43.9 Malignant melanoma of skin, unspecified
0.801 0.198 0.000
C50-C50 Malignant neoplasm of breast
0.801 0.199 0.000
D46.4 Refractory anaemia, unspecified
0.800 0.200 0.000
M81 Osteoporosis without pathological fracture
0.799 0.201 0.000
L72.8 Other follicular cysts of skin and subcutaneous tissue
0.795 0.205 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.794 0.206 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.793 0.207 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.791 0.209 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.790 0.210 0.000
L85.9 Epidermal thickening, unspecified
0.787 0.213 0.000
M40 Kyphosis and lordosis
0.787 0.213 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.784 0.216 0.000
D41.0 Kidney
0.781 0.219 0.000
M50-M54 Other dorsopathies
0.779 0.221 0.000
M48 Other spondylopathies
0.778 0.222 0.000
C44.9 Malignant neoplasm of skin, unspecified
0.777 0.223 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.777 0.223 0.000
L81.2 Freckles
0.776 0.224 0.000
C69 Malignant neoplasm of eye and adnexa
0.776 0.224 0.000
D47.2 Monoclonal gammopathy
0.775 0.224 0.000
C68 Malignant neoplasm of other and unspecified urinary organs
0.774 0.226 0.000
M43.6 Torticollis
0.773 0.227 0.000
H04.2 Epiphora
0.771 0.229 0.000
H34.2 Other retinal artery occlusions
0.770 0.230 0.000
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.769 0.231 0.000
M23.5 Chronic instability of knee
0.769 0.231 0.000
C66 Malignant neoplasm of ureter
0.768 0.232 0.000
H43-H45 Disorders of vitreous body and globe
0.767 0.233 0.000
M84.4 Pathological fracture, not elsewhere classified
0.766 0.234 0.000
D46.2 Refractory anaemia with excess of blasts
0.765 0.235 0.000
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)
0.765 0.235 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.764 0.236 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.764 0.236 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.760 0.240 0.000
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.759 0.241 0.000
H02.1 Ectropion of eyelid
0.758 0.242 0.000
Y45.2 Propionic acid derivatives
0.758 0.242 0.000
L10-L14 Bullous disorders
0.758 0.242 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.756 0.244 0.000
D03.2 Melanoma in situ of ear and external auricular canal
0.755 0.245 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.755 0.245 0.000
M43.16 Spondylolisthesis (Lumbar region)
0.754 0.246 0.000
M84.2 Delayed union of fracture
0.752 0.247 0.000
M81.4 Drug-induced osteoporosis
0.752 0.247 0.000
M51 Other intervertebral disk disorders
0.752 0.248 0.000
H53.0 Amblyopia ex anopsia
0.752 0.248 0.000
C71.2 Temporal lobe
0.751 0.249 0.000
C13 Malignant neoplasm of hypopharynx
0.750 0.250 0.000
M80.0 Postmenopausal osteoporosis with pathological fracture
0.750 0.250 0.000
M23.4 Loose body in knee
0.749 0.251 0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)
0.747 0.253 0.000
L56 Other acute skin changes due to ultraviolet radiation
0.746 0.254 0.000
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)
0.746 0.254 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.746 0.254 0.000
L83 Acanthosis nigricans
0.745 0.255 0.000
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)
0.743 0.257 0.000
C65 Malignant neoplasm of renal pelvis
0.742 0.258 0.000
M41 Scoliosis
0.741 0.259 0.000
C71.4 Occipital lobe
0.739 0.260 0.000
M23.0 Cystic meniscus
0.739 0.261 0.000
M62 Other disorders of muscle
0.738 0.262 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.737 0.263 0.000
H53.1 Subjective visual disturbances
0.737 0.263 0.000
C67 Malignant neoplasm of bladder
0.737 0.263 0.000
H02.0 Entropion and trichiasis of eyelid
0.737 0.263 0.000
D41.4 Bladder
0.736 0.264 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.735 0.264 0.000
L89.3 Stage IV decubitus ulcer
0.735 0.265 0.000
M24 Other specific joint derangements
0.732 0.268 0.000
M94 Other disorders of cartilage
0.732 0.268 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.731 0.268 0.000
M25 Other joint disorders, not elsewhere classified
0.730 0.270 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.730 0.270 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.730 0.270 0.000
L50-L54 Urticaria and erythema
0.729 0.271 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.729 0.271 0.000
H34.8 Other retinal vascular occlusions
0.728 0.272 0.000
M23.1 Discoid meniscus (congenital)
0.727 0.273 0.000
M32 Systemic lupus erythematosus
0.723 0.277 0.000
C04 Malignant neoplasm of floor of mouth
0.721 0.279 0.000
H53.9 Visual disturbance, unspecified
0.720 0.280 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.717 0.283 0.000
C43.8 Overlapping malignant melanoma of skin
0.717 0.283 0.000
C43.0 Malignant melanoma of lip
0.717 0.283 0.000
C44.8 Overlapping lesion of skin
0.717 0.283 0.000
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.717 0.283 0.000
L87 Transepidermal elimination disorders
0.717 0.283 0.000
L88 Pyoderma gangrenosum
0.717 0.283 0.000
L86 Keratoderma in diseases classified elsewhere
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
M22 Disorders of patella
0.717 0.283 0.000
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.717 0.283 0.000
L58 Radiodermatitis
0.717 0.283 0.000
L55 Sunburn
0.717 0.283 0.000
L57.5 Actinic granuloma
0.717 0.283 0.000
L57.4 Cutis laxa senilis
0.717 0.283 0.000
L57.3 Poikiloderma of Civatte
0.717 0.283 0.000
L57.2 Cutis rhomboidalis nuchae
0.717 0.283 0.000
L57.1 Actinic reticuloid
0.717 0.283 0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture
0.716 0.283 0.000
L90.9 Atrophic disorder of skin, unspecified
0.716 0.284 0.000
L90.8 Other atrophic disorders of skin
0.716 0.284 0.000
L90.6 Striae atrophicae
0.716 0.284 0.000
L90.4 Acrodermatitis chronica atrophicans
0.716 0.284 0.000
L90.3 Atrophoderma of Pasini and Pierini
0.716 0.284 0.000
L90.2 Anetoderma of Jadassohn-Pellizzari
0.716 0.284 0.000
L90.1 Anetoderma of Schweninger-Buzzi
0.716 0.284 0.000
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.716 0.284 0.000
L81.7 Pigmented purpuric dermatosis
0.716 0.284 0.000
L81.6 Other disorders of diminished melanin formation
0.716 0.284 0.000
L81.5 Leukoderma, not elsewhere classified
0.716 0.284 0.000
L81.3 Cafe au lait spots
0.716 0.284 0.000
L81.1 Chloasma
0.716 0.284 0.000
L81.0 Postinflammatory hyperpigmentation
0.716 0.284 0.000
M46 Other inflammatory spondylopathies
0.715 0.285 0.000
L75 Apocrine sweat disorders
0.714 0.286 0.000
L74 Eccrine sweat disorders
0.714 0.286 0.000
L68 Hypertrichosis
0.714 0.286 0.000
L67 Hair colour and hair shaft abnormalities
0.714 0.286 0.000
L66 Cicatricial alopecia [scarring hair loss]
0.714 0.286 0.000
L64 Androgenic alopecia
0.714 0.286 0.000
L63 Alopecia areata
0.714 0.286 0.000
L62 Nail disorders in diseases classified elsewhere
0.714 0.286 0.000
L72.2 Steatocystoma multiplex
0.714 0.286 0.000
M83 Adult osteomalacia
0.712 0.288 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.712 0.288 0.000
M85 Other disorders of bone density and structure
0.711 0.289 0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular
0.711 0.289 0.000
M87 Osteonecrosis
0.710 0.290 0.000
D03.9 Melanoma in situ, unspecified
0.709 0.291 0.000
D03.8 Melanoma in situ of other sites
0.709 0.291 0.000
D03.1 Melanoma in situ of eyelid, including canthus
0.709 0.291 0.000
D03.0 Melanoma in situ of lip
0.709 0.291 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.708 0.291 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.707 0.293 0.000
D41.2 Ureter
0.707 0.293 0.000
M81.40 Drug-induced osteoporosis (Multiple sites)
0.706 0.294 0.000
M23.9 Internal derangement of knee, unspecified
0.704 0.296 0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
0.704 0.296 0.000
C70 Malignant neoplasm of meninges
0.704 0.296 0.000
M00 Pyogenic arthritis
0.704 0.296 0.000
M30 Polyarteritis nodosa and related conditions
0.704 0.296 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.701 0.299 0.000
C71.3 Parietal lobe
0.701 0.299 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.700 0.300 0.000
C00 Malignant neoplasm of lip
0.700 0.300 0.000
M23.80 Other internal derangements of knee (Multiple sites)
0.699 0.301 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.698 0.302 0.000
C73 Malignant neoplasm of thyroid gland
0.698 0.302 0.000
X10-X19 Contact with heat and hot substances
0.697 0.303 0.000
L98.4 Chronic ulcer of skin, not elsewhere classified
0.696 0.304 0.000
Q38.7 Pharyngeal pouch
0.696 0.304 0.000
M88 Paget's disease of bone [osteitis deformans]
0.695 0.305 0.000
W75-W84 Other accidental threats to breathing
0.694 0.306 0.000
C01 Malignant neoplasm of base of tongue
0.694 0.306 0.000
M80.5 Idiopathic osteoporosis with pathological fracture
0.693 0.306 0.000
C06 Malignant neoplasm of other and unspecified parts of mouth
0.693 0.307 0.000
M21 Other acquired deformities of limbs
0.693 0.307 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.692 0.308 0.000
C71.8 Overlapping lesion of brain
0.691 0.309 0.000
C71.7 Brain stem
0.691 0.309 0.000
C71.6 Cerebellum
0.691 0.309 0.000
C71.5 Cerebral ventricle
0.691 0.309 0.000
W00-W19 Falls
0.691 0.309 0.000
Q66 Congenital deformities of feet
0.689 0.311 0.000
M42 Spinal osteochondrosis
0.688 0.312 0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)
0.688 0.312 0.000
M84.9 Disorder of continuity of bone, unspecified
0.688 0.312 0.000
M84.8 Other disorders of continuity of bone
0.688 0.312 0.000
M84.3 Stress fracture, not elsewhere classified
0.688 0.312 0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)
0.687 0.313 0.000
M80.8 Other osteoporosis with pathological fracture
0.684 0.316 0.000
M80.4 Drug-induced osteoporosis with pathological fracture
0.684 0.316 0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture
0.684 0.316 0.000
M80.2 Osteoporosis of disuse with pathological fracture
0.684 0.316 0.000
C08 Malignant neoplasm of other and unspecified major salivary glands
0.684 0.316 0.000
L85.1 Acquired keratosis [keratoderma] palmaris et plantaris
0.684 0.316 0.000
X20-X29 Contact with venomous animals and plants
0.683 0.317 0.000
D46.7 Other myelodysplastic syndromes
0.682 0.318 0.000
D46.6 Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
0.682 0.318 0.000
D46.5 Refractory anaemia with multi-lineage dysplasia
0.682 0.318 0.000
D46.3 Refractory anaemia with excess of blasts with transformation
0.682 0.318 0.000
D46.1 Refractory anaemia with sideroblasts
0.682 0.318 0.000
D46.0 Refractory anaemia without sideroblasts, so stated
0.682 0.318 0.000
D04 Carcinoma in situ of skin
0.682 0.318 0.000
Y48 Anaesthetics and therapeutic gases
0.682 0.318 0.000
C12 Malignant neoplasm of pyriform sinus
0.681 0.319 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.681 0.319 0.000
L94 Other localised connective tissue disorders
0.680 0.320 0.000
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.679 0.321 0.000
Q80-Q89 Other congenital malformations
0.679 0.321 0.000
M43.62 Torticollis-Cervical
0.679 0.321 0.000
L85.3 Xerosis cutis
0.678 0.322 0.000
L85.2 Keratosis punctata (palmaris et plantaris)
0.678 0.322 0.000
L85.0 Acquired ichthyosis
0.678 0.322 0.000
Y00-Y09 Assault
0.677 0.322 0.000
H02.6 Xanthelasma of eyelid
0.676 0.324 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.676 0.324 0.000
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)
0.675 0.325 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.675 0.325 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.675 0.325 0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified
0.675 0.325 0.000
D03.7 Melanoma in situ of lower limb, including hip
0.675 0.325 0.000
M51.2 Other specified intervertebral disk displacement
0.672 0.328 0.000
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)
0.672 0.328 0.000
V95-V97 Air and space transport accidents
0.672 0.328 0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.671 0.329 0.000
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)
0.669 0.331 0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)
0.669 0.331 0.000
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.668 0.332 0.000
V80-V89 Other land transport accidents
0.668 0.332 0.000
L71 Rosacea
0.667 0.333 0.000
C48 Malignant neoplasm of retroperitoneum and peritoneum
0.667 0.333 0.000
L70.0 Acne vulgaris
0.666 0.334 0.000
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)
0.666 0.334 0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)
0.665 0.335 0.000
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
0.665 0.335 0.000
Y42.7 Androgens and anabolic congeners
0.665 0.335 0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system
0.664 0.336 0.000
M40.2 Other and unspecified kyphosis
0.663 0.337 0.000
L95 Vasculitis limited to skin, not elsewhere classified
0.662 0.338 0.000
C05 Malignant neoplasm of palate
0.662 0.338 0.000
C43.2 Malignant melanoma of ear and external auricular canal
0.661 0.339 0.000
Y85 Sequelae of transport accidents
0.661 0.339 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.658 0.342 0.000
C50 Malignant neoplasm of breast
0.658 0.342 0.000
H04.9 Disorder of lachrymal system, unspecified
0.657 0.343 0.000
C11 Malignant neoplasm of nasopharynx
0.655 0.345 0.000
H53.6 Night blindness
0.654 0.345 0.000
H53.5 Colour vision deficiencies
0.654 0.345 0.000
H53.3 Other disorders of binocular vision
0.654 0.345 0.000
M49 Spondylopathies in diseases classified elsewhere
0.654 0.346 0.000
M43.12 Spondylolisthesis (Cervical region)
0.654 0.346 0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)
0.653 0.347 0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)
0.653 0.347 0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)
0.653 0.347 0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)
0.653 0.347 0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)
0.653 0.347 0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)
0.653 0.347 0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)
0.653 0.347 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.653 0.347 0.000
M25.3 Other instability of joint
0.652 0.348 0.000
D47.1 Chronic myeloproliferative disease
0.652 0.348 0.000
Q76 Congenital malformations of spine and bony thorax
0.651 0.348 0.000
W50-W64 Exposure to animate mechanical forces
0.649 0.351 0.000
M43.9 Deforming dorsopathy, unspecified
0.648 0.352 0.000
M43.8 Other specified deforming dorsopathies
0.648 0.352 0.000
M43.5 Other recurrent vertebral subluxation
0.648 0.352 0.000
M43.4 Other recurrent atlantoaxial subluxation
0.648 0.352 0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy
0.648 0.352 0.000
M43.2 Other fusion of spine
0.648 0.352 0.000
M51.9 Intervertebral disk disorder, unspecified
0.648 0.352 0.000
D41.9 Urinary organ, unspecified
0.647 0.352 0.000
D41.7 Other urinary organs
0.647 0.352 0.000
D41.3 Urethra
0.647 0.352 0.000
D41.1 Renal pelvis
0.647 0.352 0.000
C13.9 Hypopharynx, unspecified
0.647 0.353 0.000
M60 Myositis
0.646 0.354 0.000
Y35-Y36 Legal intervention and operations of war
0.645 0.354 0.000
Y10-Y34 Event of undetermined intent
0.645 0.354 0.000
X85-X99 Assault
0.645 0.354 0.000
X30-X39 Exposure to forces of nature
0.645 0.354 0.000
X00-X09 Exposure to smoke, fire and flames
0.645 0.354 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.645 0.354 0.000
W65-W74 Accidental drowning and submersion
0.645 0.354 0.000
V90-V94 Water transport accidents
0.645 0.354 0.000
V70-V79 Bus occupant injured in transport accident
0.645 0.354 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.645 0.354 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.645 0.354 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.645 0.354 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.645 0.355 0.000
M45 Ankylosing spondylitis
0.645 0.355 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.644 0.356 0.000
L65 Other nonscarring hair loss
0.644 0.356 0.000
V98-V99 Other and unspecified transport accidents
0.643 0.357 0.000
L93 Lupus erythematosus
0.643 0.357 0.000
Q50-Q56 Congenital malformations of genital organs
0.642 0.358 0.000
C03 Malignant neoplasm of gum
0.642 0.358 0.000
H35 Other retinal disorders
0.642 0.358 0.000
M25.8 Other specified joint disorders
0.640 0.360 0.000
C43.7 Malignant melanoma of lower limb, including hip
0.640 0.360 0.000
C71.1 Frontal lobe
0.639 0.361 0.000
Q43 Other congenital malformations of intestine
0.639 0.361 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.638 0.362 0.000
Y89 Sequelae of other external causes
0.637 0.363 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.636 0.364 0.000
H18 Other disorders of cornea
0.635 0.365 0.000
C50.2 Upper-inner quadrant of breast
0.634 0.366 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.634 0.366 0.000
C67.8 Overlapping lesion of bladder
0.634 0.366 0.000
V01-V09 Pedestrian injured in transport accident
0.634 0.366 0.000
C10 Malignant neoplasm of oropharynx
0.633 0.367 0.000
L98.1 Factitial dermatitis
0.633 0.367 0.000
L72.9 Follicular cyst of skin and subcutaneous tissue, unspecified
0.633 0.367 0.000
M62.8 Other specified disorders of muscle
0.633 0.367 0.000
Y40 Systemic antibiotics
0.632 0.368 0.000
C68.9 Urinary organ, unspecified
0.632 0.368 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.631 0.369 0.000
M22.9 Disorder of patella, unspecified
0.629 0.371 0.000
M90 Osteopathies in diseases classified elsewhere
0.628 0.372 0.000
Y59 Other and unspecified vaccines and biological substances
0.627 0.373 0.000
Y58 Bacterial vaccines
0.627 0.373 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.627 0.373 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.627 0.373 0.000
H34.1 Central retinal artery occlusion
0.626 0.374 0.000
H02.2 Lagophthalmos
0.626 0.374 0.000
H06.2 Dysthyroid exophthalmos
0.625 0.375 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.625 0.375 0.000
D47.4 Osteomyelofibrosis
0.624 0.375 0.000
Y44 Agents primarily affecting blood constituents
0.622 0.378 0.000
D05 Carcinoma in situ of breast
0.621 0.379 0.000
D09 Carcinoma in situ of other and unspecified sites
0.621 0.379 0.000
Q35-Q37 Cleft lip and cleft palate
0.620 0.379 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.620 0.379 0.000
M84.42 Pathological fracture, not elsewhere classified (Upper arm)
0.620 0.380 0.000
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.620 0.380 0.000
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]
0.620 0.380 0.000
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour
0.620 0.380 0.000
H02.3 Blepharochalasis
0.619 0.381 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.619 0.381 0.000
M20.5 Other deformities of toe(s) (acquired)
0.619 0.381 0.000
Q66.8 Other congenital deformities of feet
0.618 0.382 0.000
H43 Disorders of vitreous body
0.618 0.382 0.000
H21 Other disorders of iris and ciliary body
0.617 0.382 0.000
H17 Corneal scars and opacities
0.617 0.383 0.000
D43.2 Brain, unspecified
0.617 0.383 0.000
M93 Other osteochondropathies
0.617 0.383 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.616 0.384 0.000
M00.9 Pyogenic arthritis, unspecified
0.615 0.385 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.614 0.386 0.000
M61 Calcification and ossification of muscle
0.614 0.386 0.000
W17 Other fall from one level to another
0.613 0.387 0.000
M21.6 Other acquired deformities of ankle and foot
0.613 0.387 0.000
Y45.0 Opioids and related analgesics
0.612 0.388 0.000
M48.50 Collapsed vertebra, not elsewhere classified (Multiple sites in spine)
0.611 0.388 0.000
M22.8 Other disorders of patella
0.611 0.388 0.000
M51.8 Other specified intervertebral disk disorders
0.611 0.389 0.000
M24.1 Other articular cartilage disorders
0.610 0.390 0.000
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
0.609 0.391 0.000
C69.3 Choroid
0.608 0.391 0.000
D43.1 Brain, infratentorial
0.608 0.392 0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified
0.607 0.393 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.607 0.393 0.000
Y52.1 Calcium-channel blockers
0.607 0.393 0.000
M43.18 Spondylolisthesis (Sacral and sacrococcygeal region)
0.606 0.393 0.000
M43.15 Spondylolisthesis (Thoracolumbar region)
0.606 0.393 0.000
M43.14 Spondylolisthesis (Thoracic region)
0.606 0.393 0.000
M43.13 Spondylolisthesis (Cervicothoracic region)
0.606 0.393 0.000
M43.11 Spondylolisthesis (Occipito-atlanto-axial region)
0.606 0.393 0.000
M43.10 Spondylolisthesis (Multiple sites in spine)
0.606 0.393 0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest
0.604 0.396 0.000
M94.9 Disorder of cartilage, unspecified
0.604 0.396 0.000
M84.26 Delayed union of fracture (Lower leg)
0.604 0.396 0.000
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)
0.604 0.396 0.000
M82 Osteoporosis in diseases classified elsewhere
0.603 0.397 0.000
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.603 0.397 0.000
H02.5 Other disorders affecting eyelid function
0.603 0.397 0.000
M25.7 Osteophyte
0.602 0.398 0.000
X60-X84 Intentional self-harm
0.600 0.400 0.000
Y46.5 Valproic acid
0.600 0.400 0.000
L80 Vitiligo
0.599 0.401 0.000
M81.49 Drug-induced osteoporosis (Site unspecified)
0.599 0.401 0.000
M48.9 Spondylopathy, unspecified
0.598 0.401 0.000
Q39 Congenital malformations of oesophagus
0.598 0.402 0.000
L60 Nail disorders
0.597 0.403 0.000
M48.55 Collapsed vertebra, not elsewhere classified (Thoracolumbar region)
0.597 0.403 0.000
D01.2 Rectum
0.595 0.405 0.000
C04.9 Floor of mouth, unspecified
0.595 0.405 0.000
M94.8 Other specified disorders of cartilage
0.595 0.405 0.000
L50 Urticaria
0.595 0.405 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.594 0.406 0.000
W01 Fall on same level from slipping, tripping and stumbling
0.594 0.406 0.000
Y52.8 Antivaricose drugs, including sclerosing agents
0.594 0.406 0.000
Y52.7 Peripheral vasodilators
0.594 0.406 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.594 0.406 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.594 0.406 0.000
H30 Chorioretinal inflammation
0.594 0.406 0.000
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.593 0.407 0.000
M43.19 Spondylolisthesis (Site unspecified)
0.593 0.407 0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)
0.593 0.407 0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere
0.593 0.407 0.000
M02 Reactive arthropathies
0.593 0.407 0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere
0.593 0.407 0.000
C68.0 Urethra
0.593 0.407 0.000
M91 Juvenile osteochondrosis of hip and pelvis
0.593 0.407 0.000
L98.5 Mucinosis of skin
0.592 0.408 0.000
D47.3 Essential (haemorrhagic) thrombocythaemia
0.591 0.409 0.000
C67.5 Bladder neck
0.589 0.411 0.000
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.589 0.411 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.589 0.411 0.000
M23.87 Other internal derangements of knee (Capsular ligament)
0.589 0.411 0.000
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)
0.589 0.411 0.000
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)
0.589 0.411 0.000
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.589 0.411 0.000
M46.2 Osteomyelitis of vertebra
0.589 0.411 0.000
M88.9 Paget's disease of bone, unspecified
0.588 0.412 0.000
Y46.2 Hydantoin derivatives
0.587 0.413 0.000
Y85.9 Sequelae of other and unspecified transport accidents
0.586 0.414 0.000
C75 Malignant neoplasm of other endocrine glands and related structures
0.586 0.414 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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