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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6456777
log Bayes Factor = 15.9435
Chromosome 6   position 27,365,994  (GRCh37) Explore rs6456777 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.355 0.645
E10.9 Without complications
0.000 0.358 0.642
E10.4 With neurological complications
0.000 0.398 0.602
E10.5 With peripheral circulatory complications
0.000 0.407 0.593
E10.6 With other specified complications
0.000 0.413 0.587
E10.8 With unspecified complications
0.000 0.457 0.543
E10-E14 Diabetes mellitus
0.000 0.502 0.498
E10.1 With ketoacidosis
0.000 0.509 0.491
E10.2 With renal complications
0.000 0.519 0.481
E10.7 With multiple complications
0.000 0.537 0.462
E10.0 With coma
0.000 0.553 0.447
E10.3 With ophthalmic complications
0.000 0.577 0.423
E13 Other specified diabetes mellitus
0.000 0.579 0.421
E14 Unspecified diabetes mellitus
0.000 0.602 0.398
E83 Disorders of mineral metabolism
0.000 0.608 0.392
E14.3 With ophthalmic complications
0.000 0.616 0.384
E13.9 Without complications
0.000 0.634 0.366
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.641 0.359
E12 Malnutrition-related diabetes mellitus
0.000 0.643 0.357
E70-E90 Metabolic disorders
0.000 0.647 0.353
K90 Intestinal malabsorption
0.000 0.688 0.312
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.692 0.308
E13.8 With unspecified complications
0.000 0.698 0.302
E13.7 With multiple complications
0.000 0.698 0.302
E13.6 With other specified complications
0.000 0.698 0.302
E13.5 With peripheral circulatory complications
0.000 0.698 0.302
E13.4 With neurological complications
0.000 0.698 0.302
E13.3 With ophthalmic complications
0.000 0.698 0.302
E13.2 With renal complications
0.000 0.698 0.302
E13.1 With ketoacidosis
0.000 0.698 0.302
E13.0 With coma
0.000 0.698 0.302
E40-E46 Malnutrition
0.000 0.699 0.301
E14.5 With peripheral circulatory complications
0.000 0.703 0.297
E88 Other metabolic disorders
0.000 0.705 0.295
E85 Amyloidosis
0.000 0.714 0.286
E14.7 With multiple complications
0.000 0.714 0.286
E14.6 With other specified complications
0.000 0.714 0.286
E14.2 Withrenal complications
0.000 0.714 0.286
E14.0 With coma
0.000 0.714 0.286
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.719 0.281
E83.8 Other disorders of mineral metabolism
0.000 0.719 0.281
E83.2 Disorders of zinc metabolism
0.000 0.719 0.281
E83.0 Disorders of copper metabolism
0.000 0.719 0.281
E14.4 With neurological complications
0.000 0.724 0.276
E16 Other disorders of pancreatic internal secretion
0.000 0.729 0.271
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.734 0.266
E46 Unspecified protein-energy malnutrition
0.000 0.741 0.259
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.741 0.259
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.743 0.257
E12.9 Without complications
0.000 0.744 0.256
E12.8 With unspecified complications
0.000 0.744 0.256
E12.7 With multiple complications
0.000 0.744 0.256
E12.6 With other specified complications
0.000 0.744 0.256
E12.5 With peripheral circulatory complications
0.000 0.744 0.256
E12.4 With neurological complications
0.000 0.744 0.256
E12.3 With ophthalmic complications
0.000 0.744 0.256
E12.2 With renal complications
0.000 0.744 0.256
E12.1 With ketoacidosis
0.000 0.744 0.256
E12.0 With coma
0.000 0.744 0.256
E84 Cystic fibrosis
0.000 0.746 0.253
E77 Disorders of glycoprotein metabolism
0.000 0.746 0.253
E76 Disorders of glycosaminoglycan metabolism
0.000 0.746 0.253
E72 Other disorders of amino-acid metabolism
0.000 0.746 0.253
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.746 0.253
E70 Disorders of aromatic amino-acid metabolism
0.000 0.746 0.253
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.746 0.253
E16.2 Hypoglycaemia, unspecified
0.000 0.748 0.252
E65-E68 Obesity and other hyperalimentation
0.000 0.757 0.243
E14.1 With ketoacidosis
0.000 0.758 0.242
E85.9 Amyloidosis, unspecified
0.000 0.761 0.239
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.763 0.237
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.763 0.237
E14.8 With unspecified complications
0.000 0.764 0.236
E79 Disorders of purine and pyrimidine metabolism
0.000 0.770 0.230
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.775 0.225
E88.8 Other specified metabolic disorders
0.000 0.776 0.224
K90.3 Pancreatic steatorrhoea
0.000 0.776 0.224
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.776 0.224
K90.1 Tropical sprue
0.000 0.776 0.224
E88.2 Lipomatosis, not elsewhere classified
0.000 0.778 0.222
E11 Non-insulin-dependent diabetes mellitus
0.000 0.778 0.222
E15 Nondiabetic hypoglycaemic coma
0.000 0.779 0.221
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.784 0.216
E45 Retarded development following protein-energy malnutrition
0.000 0.784 0.216
E43 Unspecified severe protein-energy malnutrition
0.000 0.784 0.216
E42 Marasmic kwashiorkor
0.000 0.784 0.216
E41 Nutritional marasmus
0.000 0.784 0.216
E40 Kwashiorkor
0.000 0.784 0.216
E85.4 Organ-limited amyloidosis
0.000 0.784 0.216
K90.8 Other intestinal malabsorption
0.000 0.784 0.215
E89.2 Postprocedural hypoparathyroidism
0.000 0.786 0.214
E88.3 Tumour lysis syndrome
0.000 0.787 0.213
E65 Localised adiposity
0.000 0.793 0.207
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.794 0.206
E85.8 Other amyloidosis
0.000 0.795 0.205
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.795 0.205
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.795 0.205
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.795 0.205
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.795 0.205
E89.0 Postprocedural hypothyroidism
0.000 0.796 0.204
E74 Other disorders of carbohydrate metabolism
0.000 0.800 0.200
E89.4 Postprocedural ovarian failure
0.000 0.801 0.199
E88.9 Metabolic disorder, unspecified
0.000 0.803 0.197
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.806 0.194
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.806 0.194
E16.4 Abnormal secretion of gastrin
0.000 0.806 0.194
E16.3 Increased secretion of glucagon
0.000 0.806 0.194
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.809 0.191
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.809 0.191
E89.5 Postprocedural testicular hypofunction
0.000 0.809 0.191
E89.1 Postprocedural hypoinsulinaemia
0.000 0.809 0.191
E75.5 Other lipid storage disorders
0.000 0.809 0.191
E85.3 Secondary systemic amyloidosis
0.000 0.809 0.191
E75.6 Lipid storage disorder, unspecified
0.000 0.814 0.186
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.814 0.186
E75.3 Sphingolipidosis, unspecified
0.000 0.814 0.186
E75.2 Other sphingolipidosis
0.000 0.814 0.186
E75.1 Other gangliosidosis
0.000 0.814 0.186
E75.0 GM2 gangliosidosis
0.000 0.814 0.186
E73 Lactose intolerance
0.001 0.815 0.184
E11.5 With peripheral circulatory complications
0.000 0.817 0.183
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.818 0.182
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.818 0.182
E70.3 Albinism
0.000 0.818 0.182
E70.2 Disorders of tyrosine metabolism
0.000 0.818 0.182
E70.1 Other hyperphenylalaninaemias
0.000 0.818 0.182
E70.0 Classical phenylketonuria
0.000 0.818 0.182
E71.3 Disorders of fatty-acid metabolism
0.000 0.818 0.182
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.818 0.182
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.818 0.182
E71.0 Maple-syrup-urine disease
0.000 0.818 0.182
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.818 0.182
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.818 0.182
E72.5 Disorders of glycine metabolism
0.000 0.818 0.182
E72.4 Disorders of ornithine metabolism
0.000 0.818 0.182
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.818 0.182
E72.2 Disorders of urea cycle metabolism
0.000 0.818 0.182
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.818 0.182
E72.0 Disorders of amino-acid transport
0.000 0.818 0.182
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.818 0.182
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.818 0.182
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.818 0.182
E76.2 Other mucopolysaccharidoses
0.000 0.818 0.182
E76.1 Mucopolysaccharidosis, type II
0.000 0.818 0.182
E76.0 Mucopolysaccharidosis, type I
0.000 0.818 0.182
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.818 0.182
E77.8 Other disorders of glycoprotein metabolism
0.000 0.818 0.182
E77.1 Defects in glycoprotein degradation
0.000 0.818 0.182
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.818 0.182
E84.9 Cystic fibrosis, unspecified
0.000 0.818 0.182
E84.8 Cystic fibrosis with other manifestations
0.000 0.818 0.182
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.818 0.182
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.818 0.182
E67 Other hyperalimentation
0.000 0.826 0.174
E68 Sequelae of hyperalimentation
0.000 0.826 0.174
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.830 0.170
E80.5 Crigler-Najjar syndrome
0.000 0.830 0.170
E80.3 Defects of catalase and peroxydase
0.000 0.830 0.170
E80.1 Porphyria cutanea tarda
0.000 0.830 0.170
E80.0 Hereditary erythropoietic porphyria
0.000 0.830 0.170
E11.0 With coma
0.000 0.830 0.170
E80.4 Gilbert's syndrome
0.000 0.830 0.170
E83.3 Disorders of phosphorus metabolism
0.000 0.831 0.169
E11.8 With unspecified complications
0.000 0.834 0.166
E00-E07 Disorders of thyroid gland
0.000 0.834 0.166
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.835 0.165
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.835 0.165
E79.1 Lesch-Nyhan syndrome
0.000 0.835 0.165
E80.2 Other porphyria
0.000 0.836 0.164
E11.1 With ketoacidosis
0.000 0.837 0.163
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.838 0.162
E80.6 Other disorders of bilirubin metabolism
0.000 0.838 0.162
E83.4 Disorders of magnesium metabolism
0.000 0.839 0.161
E11.2 With renal complications
0.000 0.839 0.161
E11.7 With multiple complications
0.000 0.840 0.160
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.843 0.157
E44.1 Mild protein-energy malnutrition
0.000 0.845 0.155
E44.0 Moderate protein-energy malnutrition
0.000 0.845 0.155
E11.6 With other specified complications
0.000 0.847 0.153
E11.4 With neurological complications
0.000 0.850 0.150
E16.1 Other hypoglycaemia
0.000 0.853 0.147
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.856 0.144
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.856 0.144
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.856 0.144
E74.2 Disorders of galactose metabolism
0.000 0.856 0.144
E74.1 Disorders of fructose metabolism
0.000 0.856 0.144
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.859 0.141
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.866 0.134
E73.8 Other lactose intolerance
0.001 0.867 0.132
E73.1 Secondary lactase deficiency
0.001 0.867 0.132
E73.0 Congenital lactase deficiency
0.001 0.867 0.132
E74.0 Glycogen storage disease
0.000 0.868 0.132
E78.4 Other hyperlipidaemia
0.000 0.868 0.132
E07 Other disorders of thyroid
0.000 0.871 0.129
E04 Other non-toxic goitre
0.000 0.872 0.128
E67.8 Other specified hyperalimentation
0.000 0.875 0.125
E67.3 Hypervitaminosis D
0.000 0.875 0.125
E67.2 Megavitamin-B6 syndrome
0.000 0.875 0.125
E67.1 Hypercarotenaemia
0.000 0.875 0.125
E67.0 Hypervitaminosis A
0.000 0.875 0.125
E14.9 Without complications
0.000 0.877 0.123
E78.6 Lipoprotein deficiency
0.000 0.877 0.123
E87.3 Alkalosis
0.000 0.879 0.121
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.881 0.119
E00 Congenital iodine-deficiency syndrome
0.000 0.881 0.119
E50-E64 Other nutritional deficiencies
0.000 0.881 0.118
E78.3 Hyperchylomicronaemia
0.000 0.883 0.117
E11.3 With ophthalmic complications
0.000 0.883 0.117
E89.3 Postprocedural hypopituitarism
0.000 0.884 0.115
E04.9 Non-toxic goitre, unspecified
0.000 0.887 0.113
E87.0 Hyperosmolality and hypernatraemia
0.000 0.888 0.112
E06 Thyroiditis
0.000 0.889 0.111
E78.1 Pure hyperglyceridaemia
0.000 0.890 0.110
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.890 0.109
E07.9 Disorder of thyroid, unspecified
0.000 0.891 0.109
E03 Other hypothyroidism
0.000 0.892 0.108
E78.2 Mixed hyperlipidaemia
0.000 0.893 0.106
E20-E35 Disorders of other endocrine glands
0.000 0.899 0.101
E87.2 Acidosis
0.000 0.902 0.098
E03.8 Other specified hypothyroidism
0.000 0.903 0.097
E87.7 Fluid overload
0.000 0.903 0.097
E83.5 Disorders of calcium metabolism
0.000 0.903 0.097
K90.9 Intestinal malabsorption, unspecified
0.001 0.903 0.096
E04.0 Non-toxic diffuse goitre
0.000 0.904 0.096
E87.4 Mixed disorder of acid-base balance
0.000 0.904 0.096
E07.1 Dyshormogenetic goitre
0.000 0.907 0.093
E07.0 Hypersecretion of calcitonin
0.000 0.907 0.093
E04.8 Other specified non-toxic goitre
0.000 0.908 0.092
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.909 0.091
E87.5 Hyperkalaemia
0.000 0.912 0.088
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.914 0.085
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.914 0.085
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.914 0.085
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.914 0.085
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.914 0.085
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.914 0.085
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.914 0.085
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.914 0.085
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.915 0.085
E63 Other nutritional deficiencies
0.000 0.915 0.085
E56 Other vitamin deficiencies
0.000 0.915 0.085
E50 Vitamin A deficiency
0.000 0.915 0.085
E60 Dietary zinc deficiency
0.000 0.915 0.085
E59 Dietary selenium deficiency
0.000 0.915 0.085
E54 Ascorbic acid deficiency
0.000 0.915 0.085
E52 Niacin deficiency [pellagra]
0.000 0.915 0.085
E58 Dietary calcium deficiency
0.000 0.916 0.084
E04.2 Non-toxic multinodular goitre
0.000 0.916 0.083
E07.8 Other specified disorders of thyroid
0.000 0.918 0.082
E66 Obesity
0.000 0.918 0.082
E06.3 Autoimmune thyroiditis
0.000 0.919 0.081
E06.5 Other chronic thyroiditis
0.000 0.920 0.080
E06.4 Drug-induced thyroiditis
0.000 0.920 0.080
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.920 0.080
E06.1 Subacute thyroiditis
0.000 0.920 0.080
E06.0 Acute thyroiditis
0.000 0.920 0.080
E51 Thiamine deficiency
0.000 0.921 0.078
E03.5 Myxoedema coma
0.000 0.922 0.078
E03.4 Atrophy of thyroid (acquired)
0.000 0.922 0.078
E03.3 Postinfectious hypothyroidism
0.000 0.922 0.078
E03.1 Congenital hypothyroidism without goitre
0.000 0.922 0.078
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.922 0.078
E28 Ovarian dysfunction
0.000 0.923 0.077
E53 Deficiency of other B group vitamins
0.000 0.923 0.077
E20 Hypoparathyroidism
0.000 0.923 0.076
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.924 0.076
E26 Hyperaldosteronism
0.000 0.924 0.075
E29 Testicular dysfunction
0.000 0.927 0.073
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.928 0.072
E32 Diseases of thymus
0.000 0.928 0.072
E31 Polyglandular dysfunction
0.000 0.928 0.072
E30 Disorders of puberty, not elsewhere classified
0.000 0.928 0.072
E25 Adrenogenital disorders
0.000 0.928 0.072
E23 Hypofunction and other disorders of pituitary gland
0.000 0.928 0.072
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.928 0.072
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.930 0.070
E06.9 Thyroiditis, unspecified
0.000 0.930 0.070
E78.8 Other disorders of lipoprotein metabolism
0.000 0.931 0.069
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.931 0.069
E28.2 Polycystic ovarian syndrome
0.000 0.931 0.069
E55 Vitamin D deficiency
0.000 0.933 0.067
E34 Other endocrine disorders
0.000 0.934 0.066
E24 Cushing's syndrome
0.000 0.934 0.066
E23.2 Diabetes insipidus
0.000 0.935 0.065
E04.1 Non-toxic single thyroid nodule
0.000 0.936 0.064
E73.9 Lactose intolerance, unspecified
0.001 0.936 0.063
E50.9 Vitamin A deficiency, unspecified
0.000 0.939 0.061
E50.8 Other manifestations of vitamin A deficiency
0.000 0.939 0.061
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.939 0.061
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.939 0.061
E50.5 Vitamin A deficiency with night blindness
0.000 0.939 0.061
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.939 0.061
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.939 0.061
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.939 0.061
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.939 0.061
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.939 0.061
E56.9 Vitamin deficiency, unspecified
0.000 0.939 0.061
E56.8 Deficiency of other vitamins
0.000 0.939 0.061
E56.1 Deficiency of vitamin K
0.000 0.939 0.061
E56.0 Deficiency of vitamin E
0.000 0.939 0.061
E63.9 Nutritional deficiency, unspecified
0.000 0.939 0.061
E63.8 Other specified nutritional deficiencies
0.000 0.939 0.061
E63.1 Imbalance of constituents of food intake
0.000 0.939 0.061
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.939 0.061
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.939 0.061
E64.8 Sequelae of other nutritional deficiencies
0.000 0.939 0.061
E64.3 Sequelae of rickets
0.000 0.939 0.061
E64.2 Sequelae of vitamin C deficiency
0.000 0.939 0.061
E64.1 Sequelae of vitamin A deficiency
0.000 0.939 0.061
E64.0 Sequelae of protein-energy malnutrition
0.000 0.939 0.061
E27 Other disorders of adrenal gland
0.000 0.939 0.060
E66.1 Drug-induced obesity
0.000 0.941 0.059
E20.9 Hypoparathyroidism, unspecified
0.000 0.941 0.059
E26.0 Primary hyperaldosteronism
0.000 0.942 0.057
E66.0 Obesity due to excess calories
0.000 0.943 0.057
E51.9 Thiamine deficiency, unspecified
0.000 0.943 0.056
E51.8 Other manifestations of thiamine deficiency
0.000 0.943 0.056
E51.1 Beriberi
0.000 0.943 0.056
E27.1 Primary adrenocortical insufficiency
0.000 0.944 0.056
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.944 0.056
E28.9 Ovarian dysfunction, unspecified
0.000 0.944 0.055
E28.8 Other ovarian dysfunction
0.000 0.944 0.055
E28.1 Androgen excess
0.000 0.944 0.055
E28.0 Oestrogen excess
0.000 0.944 0.055
E53.1 Pyridoxine deficiency
0.000 0.944 0.055
E53.0 Riboflavin deficiency
0.000 0.944 0.055
E20.8 Other hypoparathyroidism
0.000 0.945 0.055
E20.1 Pseudohypoparathyroidism
0.000 0.945 0.055
E20.0 Idiopathic hypoparathyroidism
0.000 0.945 0.055
E53.9 Vitamin B deficiency, unspecified
0.000 0.945 0.055
E24.2 Drug-induced Cushing's syndrome
0.000 0.945 0.055
E26.9 Hyperaldosteronism, unspecified
0.000 0.946 0.054
E26.8 Other hyperaldosteronism
0.000 0.946 0.054
E26.1 Secondary hyperaldosteronism
0.000 0.946 0.054
E05.8 Other thyrotoxicosis
0.000 0.947 0.053
E29.1 Testicular hypofunction
0.000 0.948 0.052
E29.9 Testicular dysfunction, unspecified
0.000 0.948 0.052
E29.8 Other testicular dysfunction
0.000 0.948 0.052
E29.0 Testicular hyperfunction
0.000 0.948 0.052
E25.9 Adrenogenital disorder, unspecified
0.000 0.948 0.052
E25.8 Other adrenogenital disorders
0.000 0.948 0.052
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.948 0.052
E30.9 Disorder of puberty, unspecified
0.000 0.948 0.052
E30.8 Other disorders of puberty
0.000 0.948 0.052
E30.1 Precocious puberty
0.000 0.948 0.052
E30.0 Delayed puberty
0.000 0.948 0.052
E31.9 Polyglandular dysfunction, unspecified
0.000 0.948 0.052
E31.8 Other polyglandular dysfunction
0.000 0.948 0.052
E31.1 Polyglandular hyperfunction
0.000 0.948 0.052
E31.0 Autoimmune polyglandular failure
0.000 0.948 0.052
E32.9 Disease of thymus, unspecified
0.000 0.948 0.052
E32.8 Other diseases of thymus
0.000 0.948 0.052
E32.1 Abscess of thymus
0.000 0.948 0.052
E32.0 Persistent hyperplasia of thymus
0.000 0.948 0.052
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.948 0.052
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.948 0.052
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.948 0.052
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.948 0.051
E23.1 Drug-induced hypopituitarism
0.000 0.948 0.051
E05.5 Thyroid crisis or storm
0.000 0.948 0.051
E05.4 Thyrotoxicosis factitia
0.000 0.948 0.051
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.948 0.051
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.948 0.051
E23.7 Disorder of pituitary gland, unspecified
0.000 0.949 0.050
E51.2 Wernicke's encephalopathy
0.000 0.950 0.050
E55.0 Rickets, active
0.000 0.951 0.048
E53.8 Deficiency of other specified B group vitamins
0.000 0.952 0.048
E34.5 Androgen resistance syndrome
0.000 0.952 0.047
E34.4 Constitutional tall stature
0.000 0.952 0.047
E34.3 Short stature, not elsewhere classified
0.000 0.952 0.047
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.952 0.047
E34.1 Other hypersecretion of intestinal hormones
0.000 0.952 0.047
E24.8 Other Cushing's syndrome
0.000 0.953 0.047
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.953 0.047
E24.3 Ectopic ACTH syndrome
0.000 0.953 0.047
E24.1 Nelson's syndrome
0.000 0.953 0.047
E34.9 Endocrine disorder, unspecified
0.000 0.953 0.047
E34.8 Other specified endocrine disorders
0.000 0.954 0.046
E23.6 Other disorders of pituitary gland
0.000 0.955 0.045
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.955 0.045
E61 Deficiency of other nutrient elements
0.001 0.955 0.044
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.956 0.044
E27.5 Adrenomedullary hyperfunction
0.000 0.956 0.043
E27.0 Other adrenocortical overactivity
0.000 0.956 0.043
E34.0 Carcinoid syndrome
0.000 0.957 0.043
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.958 0.042
E24.0 Pituitary-dependent Cushing's disease
0.000 0.958 0.042
E86 Volume depletion
0.000 0.962 0.038
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.963 0.037
E28.3 Primary ovarian failure
0.000 0.964 0.035
E27.2 Addisonian crisis
0.000 0.966 0.034
E24.9 Cushing's syndrome, unspecified
0.000 0.966 0.033
E61.9 Deficiency of nutrient element, unspecified
0.001 0.968 0.031
E61.8 Deficiency of other specified nutrient elements
0.001 0.968 0.031
E61.7 Deficiency of multiple nutrient elements
0.001 0.968 0.031
E61.6 Vanadium deficiency
0.001 0.968 0.031
E61.5 Molybdenum deficiency
0.001 0.968 0.031
E61.4 Chromium deficiency
0.001 0.968 0.031
E61.3 Manganese deficiency
0.001 0.968 0.031
E61.0 Copper deficiency
0.001 0.968 0.031
E22 Hyperfunction of pituitary gland
0.000 0.968 0.032
E21.3 Hyperparathyroidism, unspecified
0.000 0.968 0.032
E21.4 Other specified disorders of parathyroid gland
0.000 0.968 0.032
E21.2 Other hyperparathyroidism
0.000 0.968 0.032
E55.9 Vitamin D deficiency, unspecified
0.000 0.969 0.031
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.970 0.029
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.970 0.029
E27.8 Other specified disorders of adrenal gland
0.000 0.972 0.028
E27.9 Disorder of adrenal gland, unspecified
0.000 0.974 0.025
E23.0 Hypopituitarism
0.000 0.975 0.025
E61.2 Magnesium deficiency
0.001 0.975 0.024
E66.9 Obesity, unspecified
0.000 0.976 0.024
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.977 0.023
E22.8 Other hyperfunction of pituitary gland
0.000 0.977 0.023
E22.1 Hyperprolactinaemia
0.000 0.979 0.021
K90-K93 Other diseases of the digestive system
0.000 0.980 0.020
E87.6 Hypokalaemia
0.000 0.983 0.017
E21.0 Primary hyperparathyroidism
0.000 0.984 0.016
E05.9 Thyrotoxicosis, unspecified
0.000 0.984 0.016
R31 Unspecified haematuria
0.015 0.985 0.000
E22.0 Acromegaly and pituitary gigantism
0.001 0.985 0.015
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.985 0.015
C71.2 Temporal lobe
0.014 0.986 0.000
C71 Malignant neoplasm of brain
0.014 0.986 0.000
C71.9 Brain, unspecified
0.014 0.986 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.001 0.988 0.011
C71.3 Parietal lobe
0.012 0.988 0.000
C71.1 Frontal lobe
0.012 0.988 0.000
E66.8 Other obesity
0.000 0.989 0.011
E61.1 Iron deficiency
0.001 0.989 0.010
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.989 0.011
K93.1 Megacolon in Chagas' disease
0.000 0.989 0.011
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.989 0.011
C71.7 Brain stem
0.011 0.989 0.000
M41.9 Scoliosis, unspecified
0.010 0.990 0.000
C71.6 Cerebellum
0.010 0.990 0.000
C71.5 Cerebral ventricle
0.010 0.990 0.000
C71.0 Cerebrum, except lobes and ventricles
0.010 0.990 0.000
M41.96 Scoliosis, unspecified (Lumbar region)
0.010 0.990 0.000
C71.8 Overlapping lesion of brain
0.010 0.990 0.000
M41.97 Scoliosis, unspecified (Lumbosacral region)
0.010 0.990 0.000
M41.94 Scoliosis, unspecified (Thoracic region)
0.010 0.990 0.000
M41.99 Scoliosis, unspecified (Site unspecified)
0.010 0.990 0.000
G44.2 Tension-type headache
0.009 0.991 0.000
C71.4 Occipital lobe
0.008 0.991 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.008 0.992 0.000
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)
0.008 0.992 0.000
M41.93 Scoliosis, unspecified (Cervicothoracic region)
0.008 0.992 0.000
M41.92 Scoliosis, unspecified (Cervical region)
0.008 0.992 0.000
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)
0.008 0.992 0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)
0.008 0.992 0.000
C69 Malignant neoplasm of eye and adnexa
0.007 0.993 0.000
G31.8 Other specified degenerative diseases of nervous system
0.000 0.993 0.007
M41.90 Scoliosis, unspecified (Multiple sites in spine)
0.007 0.993 0.000
C70 Malignant neoplasm of meninges
0.006 0.993 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.006 0.994 0.000
C69.9 Eye, unspecified
0.006 0.994 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.000 0.994 0.006
N04.9 Unspecified
0.000 0.994 0.006
G54.9 Nerve root and plexus disorder, unspecified
0.006 0.994 0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
0.006 0.994 0.000
G31.0 Circumscribed brain atrophy
0.000 0.994 0.006
C69.3 Choroid
0.006 0.994 0.000
M79.10 Myalgia (Multiple sites)
0.006 0.994 0.000
Z86.1 Personal history of infectious and parasitic diseases
0.000 0.994 0.006
C69.8 Overlapping lesion of eye and adnexa
0.005 0.995 0.000
C69.5 Lachrymal gland and duct
0.005 0.995 0.000
C69.4 Ciliary body
0.005 0.995 0.000
C69.2 Retina
0.005 0.995 0.000
C69.1 Cornea
0.005 0.995 0.000
C70.0 Cerebral meninges
0.005 0.995 0.000
C69.6 Orbit
0.005 0.995 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.000 0.995 0.005
C69.0 Conjunctiva
0.005 0.995 0.000
M41 Scoliosis
0.005 0.995 0.000
C70.9 Meninges, unspecified
0.005 0.995 0.000
C70.1 Spinal meninges
0.005 0.995 0.000
G44 Other headache syndromes
0.005 0.995 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.995 0.005
G31.1 Senile degeneration of brain, not elsewhere classified
0.000 0.995 0.004
R52.1 Chronic intractable pain
0.005 0.995 0.000
C72.9 Central nervous system, unspecified
0.004 0.995 0.000
C72.8 Overlapping lesion of brain and other parts of central nervous system
0.004 0.995 0.000
C72.5 Other and unspecified cranial nerves
0.004 0.995 0.000
C72.4 Acoustic nerve
0.004 0.995 0.000
C72.3 Optic nerve
0.004 0.995 0.000
C72.2 Olfactory nerve
0.004 0.995 0.000
C72.1 Cauda equina
0.004 0.995 0.000
M67.8 Other specified disorders of synovium and tendon
0.000 0.996 0.004
G44.8 Other specified headache syndromes
0.004 0.996 0.000
E11.9 Without complications
0.000 0.996 0.004
C72.0 Spinal cord
0.004 0.996 0.000
I31.9 Disease of pericardium, unspecified
0.000 0.996 0.004
M41.5 Other secondary scoliosis
0.004 0.996 0.000
M41.4 Neuromuscular scoliosis
0.004 0.996 0.000
M41.3 Thoracogenic scoliosis
0.004 0.996 0.000
M41.2 Other idiopathic scoliosis
0.004 0.996 0.000
M41.1 Juvenile idiopathic scoliosis
0.004 0.996 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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