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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6456778
log Bayes Factor = 15.6523
Chromosome 6   position 27,370,046  (GRCh37) Explore rs6456778 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.557 0.443
E10.9 Without complications
0.000 0.560 0.440
E10.4 With neurological complications
0.000 0.587 0.413
E10.5 With peripheral circulatory complications
0.000 0.593 0.407
E10.6 With other specified complications
0.000 0.601 0.399
E10.8 With unspecified complications
0.000 0.627 0.373
E10.1 With ketoacidosis
0.000 0.668 0.332
E10.2 With renal complications
0.000 0.669 0.331
E10-E14 Diabetes mellitus
0.000 0.674 0.326
E10.7 With multiple complications
0.000 0.682 0.318
E10.0 With coma
0.000 0.700 0.300
E10.3 With ophthalmic complications
0.000 0.709 0.291
E13 Other specified diabetes mellitus
0.000 0.720 0.279
K90 Intestinal malabsorption
0.000 0.722 0.278
E83 Disorders of mineral metabolism
0.000 0.726 0.274
E13.9 Without complications
0.000 0.752 0.248
E14 Unspecified diabetes mellitus
0.000 0.752 0.248
E14.3 With ophthalmic complications
0.000 0.763 0.237
E12 Malnutrition-related diabetes mellitus
0.000 0.766 0.234
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.769 0.231
E70-E90 Metabolic disorders
0.000 0.772 0.228
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.781 0.219
E13.8 With unspecified complications
0.000 0.799 0.200
E13.7 With multiple complications
0.000 0.799 0.200
E13.6 With other specified complications
0.000 0.799 0.200
E13.5 With peripheral circulatory complications
0.000 0.799 0.200
E13.4 With neurological complications
0.000 0.799 0.200
E13.2 With renal complications
0.000 0.799 0.200
E13.1 With ketoacidosis
0.000 0.799 0.200
E13.0 With coma
0.000 0.799 0.200
K90.3 Pancreatic steatorrhoea
0.000 0.801 0.199
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.801 0.199
K90.1 Tropical sprue
0.000 0.801 0.199
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.803 0.197
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.803 0.197
E83.8 Other disorders of mineral metabolism
0.000 0.803 0.197
E83.2 Disorders of zinc metabolism
0.000 0.803 0.197
E83.0 Disorders of copper metabolism
0.000 0.803 0.197
E13.3 With ophthalmic complications
0.000 0.804 0.196
E40-E46 Malnutrition
0.000 0.806 0.194
K90.8 Other intestinal malabsorption
0.000 0.808 0.192
E88 Other metabolic disorders
0.000 0.811 0.189
E14.5 With peripheral circulatory complications
0.000 0.815 0.185
E85 Amyloidosis
0.000 0.816 0.184
E14.7 With multiple complications
0.000 0.822 0.178
E14.6 With other specified complications
0.000 0.822 0.178
E14.2 Withrenal complications
0.000 0.822 0.178
E14.0 With coma
0.000 0.822 0.178
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.823 0.177
E16 Other disorders of pancreatic internal secretion
0.000 0.827 0.173
E14.4 With neurological complications
0.000 0.828 0.172
E12.9 Without complications
0.000 0.832 0.168
E12.8 With unspecified complications
0.000 0.832 0.168
E12.7 With multiple complications
0.000 0.832 0.168
E12.6 With other specified complications
0.000 0.832 0.168
E12.5 With peripheral circulatory complications
0.000 0.832 0.168
E12.4 With neurological complications
0.000 0.832 0.168
E12.3 With ophthalmic complications
0.000 0.832 0.168
E12.2 With renal complications
0.000 0.832 0.168
E12.1 With ketoacidosis
0.000 0.832 0.168
E12.0 With coma
0.000 0.832 0.168
E46 Unspecified protein-energy malnutrition
0.000 0.833 0.167
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.833 0.167
E84 Cystic fibrosis
0.000 0.836 0.163
E77 Disorders of glycoprotein metabolism
0.000 0.836 0.163
E76 Disorders of glycosaminoglycan metabolism
0.000 0.836 0.163
E72 Other disorders of amino-acid metabolism
0.000 0.836 0.163
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.836 0.163
E70 Disorders of aromatic amino-acid metabolism
0.000 0.836 0.163
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.836 0.163
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.838 0.162
E16.2 Hypoglycaemia, unspecified
0.000 0.838 0.162
E65-E68 Obesity and other hyperalimentation
0.000 0.842 0.158
E85.9 Amyloidosis, unspecified
0.000 0.846 0.154
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.846 0.154
E14.1 With ketoacidosis
0.000 0.849 0.151
E79 Disorders of purine and pyrimidine metabolism
0.000 0.852 0.148
E14.8 With unspecified complications
0.000 0.853 0.147
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.856 0.144
E88.2 Lipomatosis, not elsewhere classified
0.000 0.858 0.142
E89.2 Postprocedural hypoparathyroidism
0.000 0.858 0.142
E15 Nondiabetic hypoglycaemic coma
0.000 0.858 0.142
E11 Non-insulin-dependent diabetes mellitus
0.000 0.860 0.140
E85.4 Organ-limited amyloidosis
0.000 0.861 0.139
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.861 0.139
E45 Retarded development following protein-energy malnutrition
0.000 0.861 0.139
E43 Unspecified severe protein-energy malnutrition
0.000 0.861 0.139
E42 Marasmic kwashiorkor
0.000 0.861 0.139
E41 Nutritional marasmus
0.000 0.861 0.139
E40 Kwashiorkor
0.000 0.861 0.139
E88.8 Other specified metabolic disorders
0.000 0.862 0.138
E89.0 Postprocedural hypothyroidism
0.000 0.863 0.137
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.863 0.137
E88.3 Tumour lysis syndrome
0.000 0.864 0.136
E65 Localised adiposity
0.000 0.865 0.135
E85.8 Other amyloidosis
0.000 0.867 0.132
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.867 0.132
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.867 0.132
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.867 0.132
E89.4 Postprocedural ovarian failure
0.000 0.868 0.132
E74 Other disorders of carbohydrate metabolism
0.000 0.871 0.129
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.871 0.128
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.873 0.127
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.873 0.127
E89.5 Postprocedural testicular hypofunction
0.000 0.873 0.127
E89.1 Postprocedural hypoinsulinaemia
0.000 0.873 0.127
E88.9 Metabolic disorder, unspecified
0.000 0.874 0.126
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.876 0.124
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.876 0.124
E16.4 Abnormal secretion of gastrin
0.000 0.876 0.124
E16.3 Increased secretion of glucagon
0.000 0.876 0.124
E80.4 Gilbert's syndrome
0.000 0.876 0.124
E85.3 Secondary systemic amyloidosis
0.000 0.877 0.123
E75.5 Other lipid storage disorders
0.000 0.877 0.123
E75.6 Lipid storage disorder, unspecified
0.000 0.880 0.120
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.880 0.120
E75.3 Sphingolipidosis, unspecified
0.000 0.880 0.120
E75.2 Other sphingolipidosis
0.000 0.880 0.120
E75.1 Other gangliosidosis
0.000 0.880 0.120
E75.0 GM2 gangliosidosis
0.000 0.880 0.120
E83.3 Disorders of phosphorus metabolism
0.000 0.882 0.118
E73 Lactose intolerance
0.001 0.882 0.118
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.882 0.117
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.882 0.117
E70.3 Albinism
0.000 0.882 0.117
E70.2 Disorders of tyrosine metabolism
0.000 0.882 0.117
E70.1 Other hyperphenylalaninaemias
0.000 0.882 0.117
E70.0 Classical phenylketonuria
0.000 0.882 0.117
E71.3 Disorders of fatty-acid metabolism
0.000 0.882 0.117
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.882 0.117
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.882 0.117
E71.0 Maple-syrup-urine disease
0.000 0.882 0.117
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.882 0.117
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.882 0.117
E72.5 Disorders of glycine metabolism
0.000 0.882 0.117
E72.4 Disorders of ornithine metabolism
0.000 0.882 0.117
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.882 0.117
E72.2 Disorders of urea cycle metabolism
0.000 0.882 0.117
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.882 0.117
E72.0 Disorders of amino-acid transport
0.000 0.882 0.117
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.882 0.117
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.882 0.117
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.882 0.117
E76.2 Other mucopolysaccharidoses
0.000 0.882 0.117
E76.1 Mucopolysaccharidosis, type II
0.000 0.882 0.117
E76.0 Mucopolysaccharidosis, type I
0.000 0.882 0.117
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.882 0.117
E77.8 Other disorders of glycoprotein metabolism
0.000 0.882 0.117
E77.1 Defects in glycoprotein degradation
0.000 0.882 0.117
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.882 0.117
E84.9 Cystic fibrosis, unspecified
0.000 0.882 0.117
E84.8 Cystic fibrosis with other manifestations
0.000 0.882 0.117
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.882 0.117
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.882 0.117
E11.5 With peripheral circulatory complications
0.000 0.883 0.117
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.884 0.116
E80.5 Crigler-Najjar syndrome
0.000 0.884 0.116
E80.3 Defects of catalase and peroxydase
0.000 0.884 0.116
E80.1 Porphyria cutanea tarda
0.000 0.884 0.116
E80.0 Hereditary erythropoietic porphyria
0.000 0.884 0.116
E67 Other hyperalimentation
0.000 0.886 0.113
E68 Sequelae of hyperalimentation
0.000 0.886 0.113
E80.2 Other porphyria
0.000 0.888 0.112
E80.6 Other disorders of bilirubin metabolism
0.000 0.889 0.111
E11.0 With coma
0.000 0.892 0.108
E83.4 Disorders of magnesium metabolism
0.000 0.893 0.107
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.893 0.106
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.893 0.106
E79.1 Lesch-Nyhan syndrome
0.000 0.893 0.106
E11.8 With unspecified complications
0.000 0.895 0.105
E11.1 With ketoacidosis
0.000 0.897 0.103
E11.7 With multiple complications
0.000 0.899 0.101
E44.1 Mild protein-energy malnutrition
0.000 0.900 0.100
E44.0 Moderate protein-energy malnutrition
0.000 0.900 0.100
E11.2 With renal complications
0.000 0.902 0.098
E00-E07 Disorders of thyroid gland
0.000 0.903 0.097
E11.6 With other specified complications
0.000 0.903 0.096
E16.1 Other hypoglycaemia
0.000 0.906 0.094
E11.4 With neurological complications
0.000 0.907 0.093
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.907 0.093
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.907 0.093
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.907 0.093
E74.2 Disorders of galactose metabolism
0.000 0.907 0.093
E74.1 Disorders of fructose metabolism
0.000 0.907 0.093
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.909 0.091
K90.9 Intestinal malabsorption, unspecified
0.001 0.913 0.086
E74.0 Glycogen storage disease
0.000 0.915 0.085
E73.8 Other lactose intolerance
0.001 0.915 0.085
E73.1 Secondary lactase deficiency
0.001 0.915 0.085
E73.0 Congenital lactase deficiency
0.001 0.915 0.085
E89.3 Postprocedural hypopituitarism
0.000 0.915 0.084
E67.8 Other specified hyperalimentation
0.000 0.918 0.081
E67.3 Hypervitaminosis D
0.000 0.918 0.081
E67.2 Megavitamin-B6 syndrome
0.000 0.918 0.081
E67.1 Hypercarotenaemia
0.000 0.918 0.081
E67.0 Hypervitaminosis A
0.000 0.918 0.081
E50-E64 Other nutritional deficiencies
0.000 0.920 0.079
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.921 0.079
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.922 0.078
E14.9 Without complications
0.000 0.924 0.076
E83.5 Disorders of calcium metabolism
0.000 0.925 0.075
E20-E35 Disorders of other endocrine glands
0.000 0.926 0.074
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.926 0.074
E07 Other disorders of thyroid
0.000 0.926 0.074
E11.3 With ophthalmic complications
0.000 0.927 0.073
E87.3 Alkalosis
0.000 0.928 0.072
E04 Other non-toxic goitre
0.000 0.928 0.072
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.929 0.070
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.930 0.069
E00 Congenital iodine-deficiency syndrome
0.000 0.930 0.069
E06 Thyroiditis
0.000 0.934 0.066
E87.0 Hyperosmolality and hypernatraemia
0.000 0.934 0.066
E03 Other hypothyroidism
0.000 0.937 0.063
E04.9 Non-toxic goitre, unspecified
0.000 0.938 0.062
E78.4 Other hyperlipidaemia
0.000 0.939 0.061
E07.9 Disorder of thyroid, unspecified
0.000 0.939 0.061
E78.6 Lipoprotein deficiency
0.000 0.941 0.059
E87.7 Fluid overload
0.000 0.942 0.058
E87.2 Acidosis
0.000 0.942 0.058
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.943 0.057
E63 Other nutritional deficiencies
0.000 0.943 0.057
E56 Other vitamin deficiencies
0.000 0.943 0.057
E50 Vitamin A deficiency
0.000 0.943 0.057
E60 Dietary zinc deficiency
0.000 0.943 0.057
E59 Dietary selenium deficiency
0.000 0.943 0.057
E54 Ascorbic acid deficiency
0.000 0.943 0.057
E52 Niacin deficiency [pellagra]
0.000 0.943 0.057
E03.8 Other specified hypothyroidism
0.000 0.943 0.057
E87.4 Mixed disorder of acid-base balance
0.000 0.943 0.057
E66 Obesity
0.000 0.943 0.057
E58 Dietary calcium deficiency
0.000 0.943 0.057
E20 Hypoparathyroidism
0.000 0.943 0.057
E28 Ovarian dysfunction
0.000 0.943 0.056
E78.3 Hyperchylomicronaemia
0.000 0.944 0.056
E26 Hyperaldosteronism
0.000 0.944 0.056
E53 Deficiency of other B group vitamins
0.000 0.946 0.054
E04.0 Non-toxic diffuse goitre
0.000 0.946 0.054
E29 Testicular dysfunction
0.000 0.946 0.054
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.946 0.053
E32 Diseases of thymus
0.000 0.946 0.053
E31 Polyglandular dysfunction
0.000 0.946 0.053
E30 Disorders of puberty, not elsewhere classified
0.000 0.946 0.053
E25 Adrenogenital disorders
0.000 0.946 0.053
E07.1 Dyshormogenetic goitre
0.000 0.947 0.053
E07.0 Hypersecretion of calcitonin
0.000 0.947 0.053
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.947 0.053
E23 Hypofunction and other disorders of pituitary gland
0.000 0.947 0.053
E78.1 Pure hyperglyceridaemia
0.000 0.947 0.053
E51 Thiamine deficiency
0.000 0.947 0.053
E04.8 Other specified non-toxic goitre
0.000 0.948 0.052
E78.2 Mixed hyperlipidaemia
0.000 0.949 0.051
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.950 0.050
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.950 0.050
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.950 0.050
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.950 0.050
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.950 0.050
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.950 0.050
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.950 0.050
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.950 0.050
E28.2 Polycystic ovarian syndrome
0.000 0.950 0.050
E27 Other disorders of adrenal gland
0.000 0.950 0.049
E06.3 Autoimmune thyroiditis
0.000 0.951 0.049
E34 Other endocrine disorders
0.000 0.951 0.049
E24 Cushing's syndrome
0.000 0.951 0.049
E23.2 Diabetes insipidus
0.000 0.951 0.049
E87.5 Hyperkalaemia
0.000 0.952 0.048
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.952 0.048
E06.5 Other chronic thyroiditis
0.000 0.953 0.047
E06.4 Drug-induced thyroiditis
0.000 0.953 0.047
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.953 0.047
E06.1 Subacute thyroiditis
0.000 0.953 0.047
E06.0 Acute thyroiditis
0.000 0.953 0.047
E04.2 Non-toxic multinodular goitre
0.000 0.953 0.047
E07.8 Other specified disorders of thyroid
0.000 0.953 0.047
E27.1 Primary adrenocortical insufficiency
0.000 0.954 0.046
E03.5 Myxoedema coma
0.000 0.954 0.045
E03.4 Atrophy of thyroid (acquired)
0.000 0.954 0.045
E03.3 Postinfectious hypothyroidism
0.000 0.954 0.045
E03.1 Congenital hypothyroidism without goitre
0.000 0.954 0.045
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.954 0.045
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.955 0.045
E55 Vitamin D deficiency
0.000 0.956 0.044
E20.9 Hypoparathyroidism, unspecified
0.000 0.956 0.044
R31 Unspecified haematuria
0.043 0.957 0.000
E26.0 Primary hyperaldosteronism
0.000 0.957 0.043
E06.9 Thyroiditis, unspecified
0.000 0.958 0.041
E50.9 Vitamin A deficiency, unspecified
0.000 0.959 0.041
E50.8 Other manifestations of vitamin A deficiency
0.000 0.959 0.041
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.959 0.041
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.959 0.041
E50.5 Vitamin A deficiency with night blindness
0.000 0.959 0.041
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.959 0.041
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.959 0.041
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.959 0.041
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.959 0.041
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.959 0.041
E56.9 Vitamin deficiency, unspecified
0.000 0.959 0.041
E56.8 Deficiency of other vitamins
0.000 0.959 0.041
E56.1 Deficiency of vitamin K
0.000 0.959 0.041
E56.0 Deficiency of vitamin E
0.000 0.959 0.041
E63.9 Nutritional deficiency, unspecified
0.000 0.959 0.041
E63.8 Other specified nutritional deficiencies
0.000 0.959 0.041
E63.1 Imbalance of constituents of food intake
0.000 0.959 0.041
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.959 0.041
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.959 0.041
E64.8 Sequelae of other nutritional deficiencies
0.000 0.959 0.041
E64.3 Sequelae of rickets
0.000 0.959 0.041
E64.2 Sequelae of vitamin C deficiency
0.000 0.959 0.041
E64.1 Sequelae of vitamin A deficiency
0.000 0.959 0.041
E64.0 Sequelae of protein-energy malnutrition
0.000 0.959 0.041
E66.1 Drug-induced obesity
0.000 0.959 0.041
E20.8 Other hypoparathyroidism
0.000 0.959 0.041
E20.1 Pseudohypoparathyroidism
0.000 0.959 0.041
E20.0 Idiopathic hypoparathyroidism
0.000 0.959 0.041
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.959 0.041
E28.9 Ovarian dysfunction, unspecified
0.000 0.959 0.041
E28.8 Other ovarian dysfunction
0.000 0.959 0.041
E28.1 Androgen excess
0.000 0.959 0.041
E28.0 Oestrogen excess
0.000 0.959 0.041
E24.2 Drug-induced Cushing's syndrome
0.000 0.959 0.040
E26.9 Hyperaldosteronism, unspecified
0.000 0.960 0.040
E26.8 Other hyperaldosteronism
0.000 0.960 0.040
E26.1 Secondary hyperaldosteronism
0.000 0.960 0.040
E73.9 Lactose intolerance, unspecified
0.001 0.960 0.039
E66.0 Obesity due to excess calories
0.000 0.960 0.039
E53.1 Pyridoxine deficiency
0.000 0.961 0.039
E53.0 Riboflavin deficiency
0.000 0.961 0.039
E29.1 Testicular hypofunction
0.000 0.961 0.039
E53.9 Vitamin B deficiency, unspecified
0.000 0.961 0.039
E29.9 Testicular dysfunction, unspecified
0.000 0.961 0.039
E29.8 Other testicular dysfunction
0.000 0.961 0.039
E29.0 Testicular hyperfunction
0.000 0.961 0.039
E25.9 Adrenogenital disorder, unspecified
0.000 0.961 0.038
E25.8 Other adrenogenital disorders
0.000 0.961 0.038
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.961 0.038
E30.9 Disorder of puberty, unspecified
0.000 0.961 0.038
E30.8 Other disorders of puberty
0.000 0.961 0.038
E30.1 Precocious puberty
0.000 0.961 0.038
E30.0 Delayed puberty
0.000 0.961 0.038
E31.9 Polyglandular dysfunction, unspecified
0.000 0.961 0.038
E31.8 Other polyglandular dysfunction
0.000 0.961 0.038
E31.1 Polyglandular hyperfunction
0.000 0.961 0.038
E31.0 Autoimmune polyglandular failure
0.000 0.961 0.038
E32.9 Disease of thymus, unspecified
0.000 0.961 0.038
E32.8 Other diseases of thymus
0.000 0.961 0.038
E32.1 Abscess of thymus
0.000 0.961 0.038
E32.0 Persistent hyperplasia of thymus
0.000 0.961 0.038
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.961 0.038
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.961 0.038
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.961 0.038
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.962 0.038
E23.1 Drug-induced hypopituitarism
0.000 0.962 0.038
E51.9 Thiamine deficiency, unspecified
0.000 0.962 0.038
E51.8 Other manifestations of thiamine deficiency
0.000 0.962 0.038
E51.1 Beriberi
0.000 0.962 0.038
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.962 0.038
E04.1 Non-toxic single thyroid nodule
0.000 0.962 0.038
E23.7 Disorder of pituitary gland, unspecified
0.000 0.962 0.037
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.963 0.037
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.963 0.037
E53.8 Deficiency of other specified B group vitamins
0.000 0.963 0.037
E27.5 Adrenomedullary hyperfunction
0.000 0.964 0.036
E27.0 Other adrenocortical overactivity
0.000 0.964 0.036
E34.5 Androgen resistance syndrome
0.000 0.965 0.035
E34.4 Constitutional tall stature
0.000 0.965 0.035
E34.3 Short stature, not elsewhere classified
0.000 0.965 0.035
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.965 0.035
E34.1 Other hypersecretion of intestinal hormones
0.000 0.965 0.035
E24.8 Other Cushing's syndrome
0.000 0.965 0.035
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.965 0.035
E24.3 Ectopic ACTH syndrome
0.000 0.965 0.035
E24.1 Nelson's syndrome
0.000 0.965 0.035
E34.9 Endocrine disorder, unspecified
0.000 0.965 0.035
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.966 0.034
E34.8 Other specified endocrine disorders
0.000 0.966 0.034
E51.2 Wernicke's encephalopathy
0.000 0.966 0.033
E23.6 Other disorders of pituitary gland
0.000 0.966 0.033
E78.8 Other disorders of lipoprotein metabolism
0.000 0.966 0.033
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.968 0.032
E34.0 Carcinoid syndrome
0.000 0.968 0.032
E55.0 Rickets, active
0.000 0.968 0.032
E24.0 Pituitary-dependent Cushing's disease
0.000 0.969 0.031
E05.8 Other thyrotoxicosis
0.000 0.969 0.031
E61 Deficiency of other nutrient elements
0.001 0.970 0.029
E27.2 Addisonian crisis
0.000 0.970 0.030
E05.5 Thyroid crisis or storm
0.000 0.970 0.029
E05.4 Thyrotoxicosis factitia
0.000 0.970 0.029
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.970 0.029
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.970 0.029
E28.3 Primary ovarian failure
0.000 0.974 0.026
E21.3 Hyperparathyroidism, unspecified
0.000 0.975 0.025
E24.9 Cushing's syndrome, unspecified
0.000 0.975 0.025
E21.4 Other specified disorders of parathyroid gland
0.000 0.975 0.025
E21.2 Other hyperparathyroidism
0.000 0.975 0.025
E22 Hyperfunction of pituitary gland
0.000 0.975 0.024
E27.8 Other specified disorders of adrenal gland
0.000 0.977 0.023
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.977 0.023
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.977 0.023
E86 Volume depletion
0.000 0.978 0.022
E61.9 Deficiency of nutrient element, unspecified
0.001 0.978 0.021
E61.8 Deficiency of other specified nutrient elements
0.001 0.978 0.021
E61.7 Deficiency of multiple nutrient elements
0.001 0.978 0.021
E61.6 Vanadium deficiency
0.001 0.978 0.021
E61.5 Molybdenum deficiency
0.001 0.978 0.021
E61.4 Chromium deficiency
0.001 0.978 0.021
E61.3 Manganese deficiency
0.001 0.978 0.021
E61.0 Copper deficiency
0.001 0.978 0.021
E27.9 Disorder of adrenal gland, unspecified
0.000 0.979 0.021
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.980 0.020
E66.9 Obesity, unspecified
0.000 0.980 0.020
E23.0 Hypopituitarism
0.000 0.981 0.019
E55.9 Vitamin D deficiency, unspecified
0.000 0.981 0.019
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.982 0.018
E22.8 Other hyperfunction of pituitary gland
0.000 0.982 0.018
K90-K93 Other diseases of the digestive system
0.000 0.982 0.018
E61.2 Magnesium deficiency
0.001 0.983 0.016
E22.1 Hyperprolactinaemia
0.000 0.984 0.016
C71.2 Temporal lobe
0.015 0.985 0.000
C71 Malignant neoplasm of brain
0.014 0.986 0.000
C71.9 Brain, unspecified
0.014 0.986 0.000
E21.0 Primary hyperparathyroidism
0.000 0.987 0.013
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.987 0.013
M41.9 Scoliosis, unspecified
0.012 0.988 0.000
M41.96 Scoliosis, unspecified (Lumbar region)
0.012 0.988 0.000
C71.3 Parietal lobe
0.012 0.988 0.000
C71.1 Frontal lobe
0.012 0.988 0.000
M41.99 Scoliosis, unspecified (Site unspecified)
0.012 0.988 0.000
E22.0 Acromegaly and pituitary gigantism
0.000 0.988 0.011
M41.97 Scoliosis, unspecified (Lumbosacral region)
0.011 0.988 0.000
M41.94 Scoliosis, unspecified (Thoracic region)
0.011 0.989 0.000
C71.7 Brain stem
0.011 0.989 0.000
C71.6 Cerebellum
0.010 0.989 0.000
C71.5 Cerebral ventricle
0.010 0.989 0.000
C71.0 Cerebrum, except lobes and ventricles
0.010 0.989 0.000
C71.8 Overlapping lesion of brain
0.010 0.990 0.000
E87.6 Hypokalaemia
0.000 0.990 0.010
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.990 0.009
G31.8 Other specified degenerative diseases of nervous system
0.000 0.990 0.010
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.990 0.009
K93.1 Megacolon in Chagas' disease
0.000 0.990 0.009
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.990 0.009
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)
0.009 0.991 0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)
0.009 0.991 0.000
M41.93 Scoliosis, unspecified (Cervicothoracic region)
0.009 0.991 0.000
M41.92 Scoliosis, unspecified (Cervical region)
0.009 0.991 0.000
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)
0.009 0.991 0.000
C71.4 Occipital lobe
0.009 0.991 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.000 0.991 0.009
G44.2 Tension-type headache
0.009 0.991 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.009 0.991 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.991 0.009
G31.0 Circumscribed brain atrophy
0.000 0.991 0.008
M41.90 Scoliosis, unspecified (Multiple sites in spine)
0.008 0.992 0.000
E66.8 Other obesity
0.000 0.992 0.008
E61.1 Iron deficiency
0.001 0.992 0.007
G31.9 Degenerative disease of nervous system, unspecified
0.000 0.992 0.008
C69 Malignant neoplasm of eye and adnexa
0.008 0.992 0.000
C70 Malignant neoplasm of meninges
0.007 0.993 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.007 0.993 0.000
C69.9 Eye, unspecified
0.007 0.993 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.000 0.993 0.006
C69.3 Choroid
0.006 0.994 0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
0.006 0.994 0.000
M79.10 Myalgia (Multiple sites)
0.006 0.994 0.000
M41 Scoliosis
0.006 0.994 0.000
G54.9 Nerve root and plexus disorder, unspecified
0.006 0.994 0.000
N04.9 Unspecified
0.000 0.994 0.006
C69.8 Overlapping lesion of eye and adnexa
0.006 0.994 0.000
C69.5 Lachrymal gland and duct
0.006 0.994 0.000
C69.4 Ciliary body
0.006 0.994 0.000
C69.2 Retina
0.006 0.994 0.000
C69.1 Cornea
0.006 0.994 0.000
C69.6 Orbit
0.006 0.994 0.000
C70.0 Cerebral meninges
0.006 0.994 0.000
C69.0 Conjunctiva
0.005 0.994 0.000
G31.2 Degeneration of nervous system due to alcohol
0.000 0.995 0.005
C70.9 Meninges, unspecified
0.005 0.995 0.000
C70.1 Spinal meninges
0.005 0.995 0.000
G30-G32 Other degenerative diseases of the nervous system
0.000 0.995 0.005
G30 Alzheimer's disease
0.000 0.995 0.005
C72.9 Central nervous system, unspecified
0.005 0.995 0.000
C72.8 Overlapping lesion of brain and other parts of central nervous system
0.005 0.995 0.000
C72.5 Other and unspecified cranial nerves
0.005 0.995 0.000
C72.4 Acoustic nerve
0.005 0.995 0.000
C72.3 Optic nerve
0.005 0.995 0.000
C72.2 Olfactory nerve
0.005 0.995 0.000
C72.1 Cauda equina
0.005 0.995 0.000
M41.5 Other secondary scoliosis
0.004 0.995 0.000
M41.4 Neuromuscular scoliosis
0.004 0.995 0.000
M41.3 Thoracogenic scoliosis
0.004 0.995 0.000
M41.2 Other idiopathic scoliosis
0.004 0.995 0.000
M41.1 Juvenile idiopathic scoliosis
0.004 0.995 0.000
M41.0 Infantile idiopathic scoliosis
0.004 0.995 0.000
M67.8 Other specified disorders of synovium and tendon
0.000 0.995 0.005
C72.0 Spinal cord
0.004 0.995 0.000
K22.6 Gastro-oesophageal laceration-haemorrhage syndrome
0.005 0.995 0.000
R52.1 Chronic intractable pain
0.004 0.996 0.000
G30.0 Alzheimer's disease with early onset
0.000 0.996 0.004

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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