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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6457721
log Bayes Factor = 9.77006
Chromosome 6   position 33,107,751  (GRCh37) Explore rs6457721 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.009 0.991
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.017 0.983
E10.1 With ketoacidosis
0.000 0.019 0.981
E00-E07 Disorders of thyroid gland
0.000 0.024 0.976
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.028 0.972
E16 Other disorders of pancreatic internal secretion
0.000 0.036 0.964
E16.2 Hypoglycaemia, unspecified
0.000 0.040 0.960
E04 Other non-toxic goitre
0.000 0.040 0.960
E10.5 With peripheral circulatory complications
0.000 0.072 0.928
E06 Thyroiditis
0.000 0.076 0.924
E04.2 Non-toxic multinodular goitre
0.000 0.084 0.916
E10.2 With renal complications
0.000 0.098 0.902
E50-E64 Other nutritional deficiencies
0.000 0.099 0.900
E04.1 Non-toxic single thyroid nodule
0.000 0.102 0.898
E06.3 Autoimmune thyroiditis
0.000 0.123 0.877
E03 Other hypothyroidism
0.000 0.127 0.873
E11 Non-insulin-dependent diabetes mellitus
0.000 0.149 0.851
E10.6 With other specified complications
0.000 0.149 0.851
E10.4 With neurological complications
0.000 0.174 0.826
E03.9 Hypothyroidism, unspecified
0.000 0.176 0.824
E53 Deficiency of other B group vitamins
0.000 0.185 0.815
E55 Vitamin D deficiency
0.000 0.187 0.813
E11.4 With neurological complications
0.000 0.214 0.786
E10.0 With coma
0.000 0.227 0.773
E53.8 Deficiency of other specified B group vitamins
0.000 0.229 0.771
E11.3 With ophthalmic complications
0.000 0.236 0.764
E11.1 With ketoacidosis
0.000 0.242 0.758
E04.0 Non-toxic diffuse goitre
0.000 0.242 0.758
E55.9 Vitamin D deficiency, unspecified
0.000 0.250 0.750
E10.8 With unspecified complications
0.000 0.273 0.727
E06.9 Thyroiditis, unspecified
0.000 0.280 0.720
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.290 0.710
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.299 0.701
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.300 0.700
E00 Congenital iodine-deficiency syndrome
0.000 0.300 0.700
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.300 0.700
E15 Nondiabetic hypoglycaemic coma
0.000 0.303 0.697
E14 Unspecified diabetes mellitus
0.000 0.307 0.693
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.309 0.691
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.309 0.691
E16.4 Abnormal secretion of gastrin
0.000 0.309 0.691
E16.3 Increased secretion of glucagon
0.000 0.309 0.691
E04.8 Other specified non-toxic goitre
0.000 0.312 0.688
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.325 0.675
E06.5 Other chronic thyroiditis
0.000 0.337 0.663
E06.4 Drug-induced thyroiditis
0.000 0.337 0.663
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.337 0.663
E06.1 Subacute thyroiditis
0.000 0.337 0.663
E06.0 Acute thyroiditis
0.000 0.337 0.663
E11.6 With other specified complications
0.000 0.347 0.653
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.354 0.646
E63 Other nutritional deficiencies
0.000 0.354 0.646
E56 Other vitamin deficiencies
0.000 0.354 0.646
E50 Vitamin A deficiency
0.000 0.354 0.646
E60 Dietary zinc deficiency
0.000 0.354 0.646
E59 Dietary selenium deficiency
0.000 0.354 0.646
E58 Dietary calcium deficiency
0.000 0.354 0.646
E54 Ascorbic acid deficiency
0.000 0.354 0.646
E52 Niacin deficiency [pellagra]
0.000 0.354 0.646
E03.5 Myxoedema coma
0.000 0.374 0.626
E03.4 Atrophy of thyroid (acquired)
0.000 0.374 0.626
E03.3 Postinfectious hypothyroidism
0.000 0.374 0.626
E03.1 Congenital hypothyroidism without goitre
0.000 0.374 0.626
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.374 0.626
E51 Thiamine deficiency
0.000 0.384 0.616
E11.7 With multiple complications
0.000 0.389 0.610
E16.1 Other hypoglycaemia
0.000 0.395 0.605
E14.3 With ophthalmic complications
0.000 0.397 0.603
E11.8 With unspecified complications
0.000 0.405 0.595
E53.1 Pyridoxine deficiency
0.000 0.415 0.584
E53.0 Riboflavin deficiency
0.000 0.415 0.584
E55.0 Rickets, active
0.000 0.417 0.583
E11.0 With coma
0.000 0.422 0.578
E20-E35 Disorders of other endocrine glands
0.000 0.429 0.571
E11.2 With renal complications
0.000 0.444 0.556
E04.9 Non-toxic goitre, unspecified
0.000 0.449 0.551
E20 Hypoparathyroidism
0.000 0.474 0.526
E13 Other specified diabetes mellitus
0.001 0.484 0.516
E12.9 Without complications
0.000 0.491 0.509
E12.8 With unspecified complications
0.000 0.491 0.509
E12.7 With multiple complications
0.000 0.491 0.509
E12.6 With other specified complications
0.000 0.491 0.509
E12.5 With peripheral circulatory complications
0.000 0.491 0.509
E12.4 With neurological complications
0.000 0.491 0.509
E12.3 With ophthalmic complications
0.000 0.491 0.509
E12.2 With renal complications
0.000 0.491 0.509
E12.1 With ketoacidosis
0.000 0.491 0.509
E12.0 With coma
0.000 0.491 0.509
E27 Other disorders of adrenal gland
0.000 0.494 0.506
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.498 0.502
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.498 0.502
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.498 0.502
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.498 0.502
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.498 0.502
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.498 0.502
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.498 0.502
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.498 0.502
E40-E46 Malnutrition
0.001 0.501 0.498
E14.1 With ketoacidosis
0.000 0.502 0.497
E14.7 With multiple complications
0.000 0.503 0.497
E14.6 With other specified complications
0.000 0.503 0.497
E14.5 With peripheral circulatory complications
0.000 0.503 0.497
E14.2 Withrenal complications
0.000 0.503 0.497
E14.0 With coma
0.000 0.503 0.497
E53.9 Vitamin B deficiency, unspecified
0.000 0.505 0.495
E20.9 Hypoparathyroidism, unspecified
0.000 0.505 0.495
E27.1 Primary adrenocortical insufficiency
0.000 0.511 0.489
E14.8 With unspecified complications
0.000 0.517 0.483
E65-E68 Obesity and other hyperalimentation
0.000 0.522 0.477
E14.4 With neurological complications
0.000 0.523 0.476
E50.9 Vitamin A deficiency, unspecified
0.000 0.537 0.463
E50.8 Other manifestations of vitamin A deficiency
0.000 0.537 0.463
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.537 0.463
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.537 0.463
E50.5 Vitamin A deficiency with night blindness
0.000 0.537 0.463
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.537 0.463
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.537 0.463
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.537 0.463
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.537 0.463
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.537 0.463
E56.9 Vitamin deficiency, unspecified
0.000 0.537 0.463
E56.8 Deficiency of other vitamins
0.000 0.537 0.463
E56.1 Deficiency of vitamin K
0.000 0.537 0.463
E56.0 Deficiency of vitamin E
0.000 0.537 0.463
E63.9 Nutritional deficiency, unspecified
0.000 0.537 0.463
E63.8 Other specified nutritional deficiencies
0.000 0.537 0.463
E63.1 Imbalance of constituents of food intake
0.000 0.537 0.463
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.537 0.463
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.537 0.463
E64.8 Sequelae of other nutritional deficiencies
0.000 0.537 0.463
E64.3 Sequelae of rickets
0.000 0.537 0.463
E64.2 Sequelae of vitamin C deficiency
0.000 0.537 0.463
E64.1 Sequelae of vitamin A deficiency
0.000 0.537 0.463
E64.0 Sequelae of protein-energy malnutrition
0.000 0.537 0.463
E07 Other disorders of thyroid
0.000 0.543 0.456
E51.9 Thiamine deficiency, unspecified
0.000 0.558 0.442
E51.8 Other manifestations of thiamine deficiency
0.000 0.558 0.442
E51.1 Beriberi
0.000 0.558 0.442
E61 Deficiency of other nutrient elements
0.000 0.561 0.439
E03.8 Other specified hypothyroidism
0.001 0.588 0.412
E51.2 Wernicke's encephalopathy
0.000 0.588 0.412
E22 Hyperfunction of pituitary gland
0.000 0.589 0.411
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.591 0.409
E32 Diseases of thymus
0.000 0.591 0.409
E31 Polyglandular dysfunction
0.000 0.591 0.409
E30 Disorders of puberty, not elsewhere classified
0.000 0.591 0.409
E25 Adrenogenital disorders
0.000 0.591 0.409
E20.8 Other hypoparathyroidism
0.000 0.622 0.377
E20.1 Pseudohypoparathyroidism
0.000 0.622 0.377
E20.0 Idiopathic hypoparathyroidism
0.000 0.622 0.377
E26 Hyperaldosteronism
0.000 0.624 0.376
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.629 0.371
E28 Ovarian dysfunction
0.000 0.630 0.370
E13.8 With unspecified complications
0.001 0.630 0.370
E13.7 With multiple complications
0.001 0.630 0.370
E13.6 With other specified complications
0.001 0.630 0.370
E13.5 With peripheral circulatory complications
0.001 0.630 0.370
E13.4 With neurological complications
0.001 0.630 0.370
E13.3 With ophthalmic complications
0.001 0.630 0.370
E13.2 With renal complications
0.001 0.630 0.370
E13.1 With ketoacidosis
0.001 0.630 0.370
E13.0 With coma
0.001 0.630 0.370
E27.5 Adrenomedullary hyperfunction
0.000 0.637 0.363
E27.0 Other adrenocortical overactivity
0.000 0.637 0.363
E44 Protein-energy malnutrition of moderate and mild degree
0.001 0.642 0.357
E45 Retarded development following protein-energy malnutrition
0.001 0.642 0.357
E43 Unspecified severe protein-energy malnutrition
0.001 0.642 0.357
E42 Marasmic kwashiorkor
0.001 0.642 0.357
E41 Nutritional marasmus
0.001 0.642 0.357
E40 Kwashiorkor
0.001 0.642 0.357
E34 Other endocrine disorders
0.000 0.643 0.357
E27.2 Addisonian crisis
0.000 0.647 0.353
E27.9 Disorder of adrenal gland, unspecified
0.000 0.650 0.350
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.653 0.347
E65 Localised adiposity
0.000 0.653 0.347
E29 Testicular dysfunction
0.000 0.656 0.344
E67 Other hyperalimentation
0.000 0.657 0.342
E68 Sequelae of hyperalimentation
0.000 0.657 0.342
E07.1 Dyshormogenetic goitre
0.000 0.672 0.327
E07.0 Hypersecretion of calcitonin
0.000 0.672 0.327
E61.9 Deficiency of nutrient element, unspecified
0.000 0.685 0.315
E61.8 Deficiency of other specified nutrient elements
0.000 0.685 0.315
E61.7 Deficiency of multiple nutrient elements
0.000 0.685 0.315
E61.6 Vanadium deficiency
0.000 0.685 0.315
E61.5 Molybdenum deficiency
0.000 0.685 0.315
E61.4 Chromium deficiency
0.000 0.685 0.315
E61.3 Manganese deficiency
0.000 0.685 0.315
E61.0 Copper deficiency
0.000 0.685 0.315
E07.8 Other specified disorders of thyroid
0.000 0.699 0.300
E14.9 Without complications
0.000 0.702 0.298
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.705 0.295
E22.8 Other hyperfunction of pituitary gland
0.000 0.705 0.295
E25.9 Adrenogenital disorder, unspecified
0.000 0.706 0.294
E25.8 Other adrenogenital disorders
0.000 0.706 0.294
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.706 0.294
E30.9 Disorder of puberty, unspecified
0.000 0.706 0.294
E30.8 Other disorders of puberty
0.000 0.706 0.294
E30.1 Precocious puberty
0.000 0.706 0.294
E30.0 Delayed puberty
0.000 0.706 0.294
E31.9 Polyglandular dysfunction, unspecified
0.000 0.706 0.294
E31.8 Other polyglandular dysfunction
0.000 0.706 0.294
E31.1 Polyglandular hyperfunction
0.000 0.706 0.294
E31.0 Autoimmune polyglandular failure
0.000 0.706 0.294
E32.9 Disease of thymus, unspecified
0.000 0.706 0.294
E32.8 Other diseases of thymus
0.000 0.706 0.294
E32.1 Abscess of thymus
0.000 0.706 0.294
E32.0 Persistent hyperplasia of thymus
0.000 0.706 0.294
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.706 0.294
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.706 0.294
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.706 0.294
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.708 0.291
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.710 0.290
E61.2 Magnesium deficiency
0.000 0.715 0.285
E28.3 Primary ovarian failure
0.000 0.715 0.285
E24 Cushing's syndrome
0.000 0.719 0.280
E27.8 Other specified disorders of adrenal gland
0.000 0.726 0.274
E26.0 Primary hyperaldosteronism
0.000 0.730 0.270
E26.8 Other hyperaldosteronism
0.000 0.730 0.270
E26.1 Secondary hyperaldosteronism
0.000 0.730 0.270
E23 Hypofunction and other disorders of pituitary gland
0.000 0.733 0.266
E28.9 Ovarian dysfunction, unspecified
0.000 0.734 0.266
E28.8 Other ovarian dysfunction
0.000 0.734 0.266
E28.1 Androgen excess
0.000 0.734 0.266
E28.0 Oestrogen excess
0.000 0.734 0.266
E22.0 Acromegaly and pituitary gigantism
0.000 0.735 0.265
E44.1 Mild protein-energy malnutrition
0.001 0.743 0.256
E44.0 Moderate protein-energy malnutrition
0.001 0.743 0.256
E34.0 Carcinoid syndrome
0.000 0.743 0.257
E34.5 Androgen resistance syndrome
0.000 0.744 0.256
E34.4 Constitutional tall stature
0.000 0.744 0.256
E34.3 Short stature, not elsewhere classified
0.000 0.744 0.256
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.744 0.256
E34.1 Other hypersecretion of intestinal hormones
0.000 0.744 0.256
E29.9 Testicular dysfunction, unspecified
0.000 0.753 0.246
E29.8 Other testicular dysfunction
0.000 0.753 0.246
E29.0 Testicular hyperfunction
0.000 0.753 0.246
E22.1 Hyperprolactinaemia
0.000 0.754 0.246
E67.8 Other specified hyperalimentation
0.000 0.754 0.246
E67.3 Hypervitaminosis D
0.000 0.754 0.246
E67.2 Megavitamin-B6 syndrome
0.000 0.754 0.246
E67.1 Hypercarotenaemia
0.000 0.754 0.246
E67.0 Hypervitaminosis A
0.000 0.754 0.246
E26.9 Hyperaldosteronism, unspecified
0.000 0.764 0.236
E34.9 Endocrine disorder, unspecified
0.000 0.764 0.236
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.766 0.234
E34.8 Other specified endocrine disorders
0.000 0.772 0.227
E11.5 With peripheral circulatory complications
0.001 0.782 0.217
E23.6 Other disorders of pituitary gland
0.000 0.785 0.215
E21.4 Other specified disorders of parathyroid gland
0.000 0.792 0.208
E21.2 Other hyperparathyroidism
0.000 0.792 0.208
E21.0 Primary hyperparathyroidism
0.000 0.796 0.204
E24.8 Other Cushing's syndrome
0.000 0.799 0.201
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.799 0.201
E24.3 Ectopic ACTH syndrome
0.000 0.799 0.201
E24.1 Nelson's syndrome
0.000 0.799 0.201
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.801 0.199
E24.2 Drug-induced Cushing's syndrome
0.000 0.801 0.198
E23.7 Disorder of pituitary gland, unspecified
0.000 0.803 0.196
E28.2 Polycystic ovarian syndrome
0.000 0.806 0.194
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.809 0.191
E23.1 Drug-induced hypopituitarism
0.000 0.809 0.191
E21.3 Hyperparathyroidism, unspecified
0.000 0.813 0.186
E29.1 Testicular hypofunction
0.000 0.819 0.181
E13.9 Without complications
0.001 0.824 0.175
E61.1 Iron deficiency
0.001 0.826 0.173
E05.5 Thyroid crisis or storm
0.000 0.832 0.168
E05.4 Thyrotoxicosis factitia
0.000 0.832 0.168
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.832 0.168
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.832 0.168
E24.9 Cushing's syndrome, unspecified
0.000 0.834 0.165
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.845 0.155
E46 Unspecified protein-energy malnutrition
0.001 0.848 0.151
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.850 0.150
E07.9 Disorder of thyroid, unspecified
0.000 0.852 0.148
E05.8 Other thyrotoxicosis
0.000 0.855 0.145
E24.0 Pituitary-dependent Cushing's disease
0.001 0.858 0.141
E23.2 Diabetes insipidus
0.001 0.890 0.109
E23.0 Hypopituitarism
0.000 0.898 0.102
E66 Obesity
0.000 0.898 0.102
R20.2 Paraesthesia of skin
0.100 0.900 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.908 0.092
E05.9 Thyrotoxicosis, unspecified
0.000 0.920 0.080
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.923 0.077
E66.1 Drug-induced obesity
0.000 0.926 0.074
E66.0 Obesity due to excess calories
0.000 0.933 0.066
E70-E90 Metabolic disorders
0.000 0.944 0.056
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.957 0.043
E83 Disorders of mineral metabolism
0.000 0.957 0.043
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.957 0.043
R20 Disturbances of skin sensation
0.043 0.957 0.000
E77 Disorders of glycoprotein metabolism
0.000 0.960 0.040
E76 Disorders of glycosaminoglycan metabolism
0.000 0.960 0.040
E72 Other disorders of amino-acid metabolism
0.000 0.960 0.040
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.960 0.040
E70 Disorders of aromatic amino-acid metabolism
0.000 0.960 0.040
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.960 0.040
E79 Disorders of purine and pyrimidine metabolism
0.000 0.960 0.040
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.961 0.039
E88 Other metabolic disorders
0.000 0.961 0.039
E84 Cystic fibrosis
0.000 0.961 0.038
E74 Other disorders of carbohydrate metabolism
0.000 0.962 0.037
E83.4 Disorders of magnesium metabolism
0.000 0.963 0.037
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.965 0.035
R20.3 Hyperaesthesia
0.035 0.965 0.000
E89.2 Postprocedural hypoparathyroidism
0.000 0.965 0.035
E73 Lactose intolerance
0.000 0.965 0.035
E83.1 Disorders of iron metabolism
0.000 0.965 0.035
E11.9 Without complications
0.000 0.967 0.033
E80.6 Other disorders of bilirubin metabolism
0.000 0.967 0.033
N81.2 Incomplete uterovaginal prolapse
0.033 0.967 0.000
E80.4 Gilbert's syndrome
0.000 0.967 0.033
E89.0 Postprocedural hypothyroidism
0.000 0.968 0.032
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.969 0.031
E80.5 Crigler-Najjar syndrome
0.000 0.969 0.031
E80.3 Defects of catalase and peroxydase
0.000 0.969 0.031
E80.2 Other porphyria
0.000 0.969 0.031
E80.1 Porphyria cutanea tarda
0.000 0.969 0.031
E80.0 Hereditary erythropoietic porphyria
0.000 0.969 0.031
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.969 0.031
E83.8 Other disorders of mineral metabolism
0.000 0.969 0.031
E83.2 Disorders of zinc metabolism
0.000 0.969 0.031
E83.0 Disorders of copper metabolism
0.000 0.969 0.031
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.969 0.031
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.969 0.031
E89.5 Postprocedural testicular hypofunction
0.000 0.969 0.031
E89.1 Postprocedural hypoinsulinaemia
0.000 0.969 0.031
R20.1 Hypoaesthesia of skin
0.031 0.969 0.000
E66.8 Other obesity
0.000 0.969 0.031
E89.3 Postprocedural hypopituitarism
0.000 0.970 0.030
E89.4 Postprocedural ovarian failure
0.000 0.970 0.029
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.971 0.029
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.971 0.029
E70.3 Albinism
0.000 0.971 0.029
E70.2 Disorders of tyrosine metabolism
0.000 0.971 0.029
E70.1 Other hyperphenylalaninaemias
0.000 0.971 0.029
E70.0 Classical phenylketonuria
0.000 0.971 0.029
E71.3 Disorders of fatty-acid metabolism
0.000 0.971 0.029
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.971 0.029
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.971 0.029
E71.0 Maple-syrup-urine disease
0.000 0.971 0.029
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.971 0.029
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.971 0.029
E72.5 Disorders of glycine metabolism
0.000 0.971 0.029
E72.4 Disorders of ornithine metabolism
0.000 0.971 0.029
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.971 0.029
E72.2 Disorders of urea cycle metabolism
0.000 0.971 0.029
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.971 0.029
E72.0 Disorders of amino-acid transport
0.000 0.971 0.029
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.971 0.029
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.971 0.029
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.971 0.029
E76.2 Other mucopolysaccharidoses
0.000 0.971 0.029
E76.1 Mucopolysaccharidosis, type II
0.000 0.971 0.029
E76.0 Mucopolysaccharidosis, type I
0.000 0.971 0.029
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.971 0.029
E77.8 Other disorders of glycoprotein metabolism
0.000 0.971 0.029
E77.1 Defects in glycoprotein degradation
0.000 0.971 0.029
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.971 0.029
R20.0 Anaesthesia of skin
0.029 0.971 0.000
E85 Amyloidosis
0.000 0.971 0.029
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.971 0.029
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.971 0.029
E79.1 Lesch-Nyhan syndrome
0.000 0.971 0.029
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.972 0.028
E75.6 Lipid storage disorder, unspecified
0.000 0.972 0.028
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.972 0.028
E75.3 Sphingolipidosis, unspecified
0.000 0.972 0.028
E75.2 Other sphingolipidosis
0.000 0.972 0.028
E75.1 Other gangliosidosis
0.000 0.972 0.028
E75.0 GM2 gangliosidosis
0.000 0.972 0.028
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.972 0.028
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.972 0.028
E84.8 Cystic fibrosis with other manifestations
0.000 0.972 0.028
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.972 0.028
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.972 0.028
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.973 0.027
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.973 0.027
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.973 0.027
E74.2 Disorders of galactose metabolism
0.000 0.973 0.027
E74.1 Disorders of fructose metabolism
0.000 0.973 0.027
E74.0 Glycogen storage disease
0.000 0.973 0.027
E75.5 Other lipid storage disorders
0.000 0.973 0.026
E88.2 Lipomatosis, not elsewhere classified
0.000 0.973 0.026
E84.9 Cystic fibrosis, unspecified
0.000 0.974 0.026
E83.5 Disorders of calcium metabolism
0.000 0.974 0.026
R20.8 Other and unspecified disturbances of skin sensation
0.026 0.974 0.000
E73.8 Other lactose intolerance
0.000 0.975 0.025
E73.1 Secondary lactase deficiency
0.000 0.975 0.025
E73.0 Congenital lactase deficiency
0.000 0.975 0.025
E88.8 Other specified metabolic disorders
0.000 0.975 0.025
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.976 0.024
E83.3 Disorders of phosphorus metabolism
0.000 0.977 0.023
E88.9 Metabolic disorder, unspecified
0.000 0.977 0.023
E88.3 Tumour lysis syndrome
0.000 0.977 0.022
E85.8 Other amyloidosis
0.000 0.979 0.021
E85.3 Secondary systemic amyloidosis
0.000 0.979 0.021
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.979 0.021
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.979 0.021
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.979 0.021
E86 Volume depletion
0.000 0.980 0.020
E73.9 Lactose intolerance, unspecified
0.000 0.981 0.019
E85.4 Organ-limited amyloidosis
0.000 0.982 0.018
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.983 0.017
E85.9 Amyloidosis, unspecified
0.000 0.985 0.015
M19.97 Arthrosis, unspecified (Ankle and foot)
0.014 0.986 0.000
E78.2 Mixed hyperlipidaemia
0.000 0.986 0.014
H36.0 Diabetic retinopathy
0.000 0.986 0.014
E78.1 Pure hyperglyceridaemia
0.000 0.987 0.013
E78.4 Other hyperlipidaemia
0.000 0.987 0.013
E78.6 Lipoprotein deficiency
0.000 0.988 0.012
E78.3 Hyperchylomicronaemia
0.000 0.988 0.012
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.988 0.012
Y85.0 Sequelae of motor-vehicle accident
0.000 0.990 0.010
E78.8 Other disorders of lipoprotein metabolism
0.000 0.991 0.009
I35.0 Aortic (valve) stenosis
0.008 0.992 0.000
Z87.8 Personal history of other specified conditions
0.000 0.994 0.006
M35.0 Sicca syndrome [Sjogren]
0.000 0.994 0.006
H36 Retinal disorders in diseases classified elsewhere
0.000 0.994 0.006
S70.9 Superficial injury of hip and thigh, unspecified
0.006 0.994 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.995 0.005
M35 Other systemic involvement of connective tissue
0.000 0.995 0.005
M35.1 Other overlap syndromes
0.000 0.995 0.005
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.995 0.005
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.995 0.005
M35.7 Hypermobility syndrome
0.000 0.995 0.005
T84.0 Mechanical complication of internal joint prosthesis
0.005 0.995 0.000
K91.4 Colostomy and enterostomy malfunction
0.000 0.996 0.004
I35 Nonrheumatic aortic valve disorders
0.004 0.996 0.000
K12.1 Other forms of stomatitis
0.000 0.996 0.004
E87.3 Alkalosis
0.000 0.996 0.004
I34.0 Mitral (valve) insufficiency
0.000 0.996 0.004
U80.1 Methicillin resistant agent
0.000 0.996 0.004
Y85 Sequelae of transport accidents
0.000 0.996 0.004
I35.2 Aortic (valve) stenosis with insufficiency
0.004 0.996 0.000
E87.4 Mixed disorder of acid-base balance
0.000 0.996 0.004
I35.1 Aortic (valve) insufficiency
0.004 0.996 0.000
M35.2 Behcet's disease
0.000 0.996 0.004
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.996 0.004
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.996 0.004
M35.5 Multifocal fibrosclerosis
0.000 0.996 0.004
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.996 0.004
K37 Unspecified appendicitis
0.000 0.996 0.004
K14.8 Other diseases of tongue
0.000 0.996 0.004
S60.9 Superficial injury of wrist and hand, unspecified
0.000 0.996 0.004
S52.60 Fracture of lower end of both ulna and radius (closed)
0.000 0.996 0.004
M35.3 Polymyalgia rheumatica
0.000 0.996 0.004
M35.8 Other specified systemic involvement of connective tissue
0.000 0.997 0.003
I35.8 Other aortic valve disorders
0.003 0.997 0.000
K90.0 Coeliac disease
0.000 0.997 0.003
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.997 0.003
U80 Agent resistant to penicillin and related antibiotics
0.000 0.997 0.003
Y85.9 Sequelae of other and unspecified transport accidents
0.000 0.997 0.003
Q50.4 Embryonic cyst of Fallopian tube
0.000 0.997 0.003
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.997 0.003
U80.8 Agent resistant to other penicillin-related antibiotic
0.000 0.997 0.003
L40.9 Psoriasis, unspecified
0.000 0.997 0.003
Q76 Congenital malformations of spine and bony thorax
0.003 0.997 0.000
H52.3 Anisometropia and aniseikonia
0.003 0.997 0.000
U80.0 Penicillin resistant agent
0.000 0.997 0.003
E87.0 Hyperosmolality and hypernatraemia
0.000 0.997 0.003
Q66.9 Congenital deformity of feet, unspecified
0.003 0.997 0.000
E87.2 Acidosis
0.000 0.997 0.003
Q66 Congenital deformities of feet
0.003 0.997 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.003 0.997 0.000
Q76.4 Other congenital malformations of spine, not associated with scoliosis
0.003 0.997 0.000
Q44.6 Cystic disease of liver
0.003 0.997 0.000
Q76.0 Spina bifida occulta
0.003 0.997 0.000
G60.0 Hereditary motor and sensory neuropathy
0.003 0.997 0.000
M31.3 Wegener's granulomatosis
0.003 0.997 0.000
M31.6 Other giant cell arteritis
0.003 0.997 0.000
A63.0 Anogenital (venereal) warts
0.000 0.997 0.003
K14.0 Glossitis
0.000 0.997 0.003
Q51.2 Other doubling of uterus
0.002 0.997 0.000
Q65 Congenital deformities of hip
0.002 0.997 0.000
N41.9 Inflammatory disease of prostate, unspecified
0.000 0.997 0.002
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.002 0.998 0.000
D12.8 Rectum
0.000 0.998 0.002
Q65.8 Other congenital deformities of hip
0.002 0.998 0.000
H52 Disorders of refraction and accommodation
0.002 0.998 0.000
Q66.2 Metatarsus varus
0.002 0.998 0.000
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes
0.002 0.998 0.000
Q66.0 Talipes equinovarus
0.002 0.998 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.002 0.998 0.000
H52.0 Hypermetropia
0.002 0.998 0.000
Q76.9 Congenital malformation of bony thorax, unspecified
0.002 0.998 0.000
Q76.8 Other congenital malformations of bony thorax
0.002 0.998 0.000
Q76.7 Congenital malformation of sternum
0.002 0.998 0.000
Q76.6 Other congenital malformations of ribs
0.002 0.998 0.000
Q76.5 Cervical rib
0.002 0.998 0.000
Q76.3 Congenital scoliosis due to congenital bony malformation
0.002 0.998 0.000
Q76.2 Congenital spondylolisthesis
0.002 0.998 0.000
Q76.1 Klippel-Feil syndrome
0.002 0.998 0.000
Q66.3 Other congenital varus deformities of feet
0.002 0.998 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.002 0.998 0.000
Q74 Other congenital malformations of limb(s)
0.002 0.998 0.000
Q66.6 Other congenital valgus deformities of feet
0.002 0.998 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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