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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs657197
log Bayes Factor = 20.0865
Chromosome 12   position 111,965,658  (GRCh37) Explore rs657197 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.002 0.998
E03 Other hypothyroidism
0.000 0.004 0.996
E00-E07 Disorders of thyroid gland
0.000 0.005 0.995
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.006 0.994
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.014 0.986
E20-E35 Disorders of other endocrine glands
0.000 0.015 0.985
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.020 0.980
E27 Other disorders of adrenal gland
0.000 0.023 0.977
I10-I15 Hypertensive diseases
0.000 0.023 0.977
Chapter IX Diseases of the circulatory system
0.000 0.026 0.974
E05.9 Thyrotoxicosis, unspecified
0.000 0.027 0.973
I22 Subsequent myocardial infarction
0.000 0.034 0.966
Z95.1 Presence of aortocoronary bypass graft
0.000 0.045 0.955
E10-E14 Diabetes mellitus
0.000 0.046 0.954
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.047 0.953
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.047 0.953
E10 Insulin-dependent diabetes mellitus
0.000 0.049 0.951
I21.9 Acute myocardial infarction, unspecified
0.000 0.049 0.951
E27.1 Primary adrenocortical insufficiency
0.000 0.053 0.947
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.055 0.945
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.066 0.934
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.088 0.912
I25.5 Ischaemic cardiomyopathy
0.000 0.089 0.911
E10.3 With ophthalmic complications
0.000 0.090 0.910
E10.9 Without complications
0.000 0.090 0.910
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.111 0.889
Z95.3 Presence of xenogenic heart valve
0.000 0.111 0.889
E23 Hypofunction and other disorders of pituitary gland
0.000 0.130 0.870
I99 Other and unspecified disorders of circulatory system
0.000 0.146 0.854
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.154 0.846
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.166 0.834
E50-E64 Other nutritional deficiencies
0.000 0.167 0.833
E21.0 Primary hyperparathyroidism
0.000 0.172 0.828
E34 Other endocrine disorders
0.000 0.184 0.816
I97.1 Other functional disturbances following cardiac surgery
0.000 0.185 0.815
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.187 0.812
E27.8 Other specified disorders of adrenal gland
0.000 0.190 0.810
E06 Thyroiditis
0.000 0.196 0.804
E10.4 With neurological complications
0.000 0.201 0.799
I25.2 Old myocardial infarction
0.000 0.202 0.798
E10.5 With peripheral circulatory complications
0.000 0.204 0.796
E28 Ovarian dysfunction
0.000 0.210 0.789
I25.4 Coronary artery aneurysm
0.000 0.216 0.784
E23.2 Diabetes insipidus
0.000 0.216 0.784
I23 Certain current complications following acute myocardial infarction
0.000 0.226 0.774
E27.2 Addisonian crisis
0.000 0.227 0.773
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.231 0.768
Z95.2 Presence of prosthetic heart valve
0.000 0.233 0.767
I30-I52 Other forms of heart disease
0.000 0.234 0.766
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.235 0.765
I35 Nonrheumatic aortic valve disorders
0.000 0.236 0.764
E10.0 With coma
0.000 0.237 0.763
I49 Other cardiac arrhythmias
0.000 0.242 0.758
I35.0 Aortic (valve) stenosis
0.000 0.245 0.755
I25.3 Aneurysm of heart
0.000 0.246 0.754
I49.9 Cardiac arrhythmia, unspecified
0.000 0.246 0.754
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.248 0.752
E22 Hyperfunction of pituitary gland
0.000 0.249 0.750
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.255 0.745
E03.8 Other specified hypothyroidism
0.000 0.264 0.736
I49.3 Ventricular premature depolarisation
0.000 0.267 0.733
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.272 0.728
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.277 0.723
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.283 0.717
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.284 0.716
E03.5 Myxoedema coma
0.000 0.286 0.714
E03.4 Atrophy of thyroid (acquired)
0.000 0.286 0.714
E03.3 Postinfectious hypothyroidism
0.000 0.286 0.714
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.286 0.714
E21.3 Hyperparathyroidism, unspecified
0.000 0.287 0.713
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.287 0.713
E00 Congenital iodine-deficiency syndrome
0.000 0.287 0.713
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.294 0.706
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.294 0.706
E32 Diseases of thymus
0.000 0.294 0.706
E31 Polyglandular dysfunction
0.000 0.294 0.706
E30 Disorders of puberty, not elsewhere classified
0.000 0.294 0.706
E10.2 With renal complications
0.000 0.297 0.703
E05.5 Thyroid crisis or storm
0.000 0.297 0.703
E05.4 Thyrotoxicosis factitia
0.000 0.297 0.703
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.297 0.703
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.297 0.703
Z95.0 Presence of cardiac pacemaker
0.000 0.297 0.703
E27.5 Adrenomedullary hyperfunction
0.000 0.299 0.701
E27.0 Other adrenocortical overactivity
0.000 0.299 0.701
I13 Hypertensive heart and renal disease
0.000 0.300 0.700
E61 Deficiency of other nutrient elements
0.000 0.301 0.699
I00-I02 Acute rheumatic fever
0.000 0.301 0.699
Z95.4 Presence of other heart-valve replacement
0.000 0.309 0.691
E10.8 With unspecified complications
0.000 0.309 0.691
I47 Paroxysmal tachycardia
0.000 0.310 0.690
E27.9 Disorder of adrenal gland, unspecified
0.000 0.312 0.688
E06.9 Thyroiditis, unspecified
0.000 0.315 0.685
I22.8 Subsequent myocardial infarction of other sites
0.000 0.315 0.685
E10.6 With other specified complications
0.000 0.315 0.685
E12 Malnutrition-related diabetes mellitus
0.000 0.316 0.684
E23.6 Other disorders of pituitary gland
0.000 0.316 0.684
E53 Deficiency of other B group vitamins
0.000 0.323 0.677
E20 Hypoparathyroidism
0.000 0.327 0.672
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.332 0.668
I47.2 Ventricular tachycardia
0.000 0.335 0.665
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.342 0.658
I20 Angina pectoris
0.000 0.342 0.658
E21.4 Other specified disorders of parathyroid gland
0.000 0.346 0.654
E21.2 Other hyperparathyroidism
0.000 0.346 0.654
I24 Other acute ischaemic heart diseases
0.000 0.347 0.653
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.348 0.652
E23.7 Disorder of pituitary gland, unspecified
0.000 0.350 0.650
E14 Unspecified diabetes mellitus
0.000 0.354 0.646
E25 Adrenogenital disorders
0.000 0.355 0.645
I20.8 Other forms of angina pectoris
0.000 0.356 0.644
E34.9 Endocrine disorder, unspecified
0.000 0.357 0.643
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.362 0.638
I97.0 Postcardiotomy syndrome
0.000 0.362 0.638
I50 Heart failure
0.000 0.363 0.637
E34.0 Carcinoid syndrome
0.000 0.366 0.634
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.368 0.632
E03.1 Congenital hypothyroidism without goitre
0.000 0.374 0.626
E26 Hyperaldosteronism
0.000 0.374 0.626
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.376 0.623
E23.1 Drug-induced hypopituitarism
0.000 0.376 0.623
E05.8 Other thyrotoxicosis
0.000 0.380 0.620
E28.3 Primary ovarian failure
0.000 0.381 0.619
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.385 0.615
I23.8 Other current complications following acute myocardial infarction
0.000 0.387 0.613
E34.8 Other specified endocrine disorders
0.000 0.390 0.610
E10.1 With ketoacidosis
0.000 0.392 0.608
E28.2 Polycystic ovarian syndrome
0.000 0.395 0.605
E06.3 Autoimmune thyroiditis
0.000 0.396 0.604
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.402 0.598
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.403 0.597
E63 Other nutritional deficiencies
0.000 0.403 0.597
E56 Other vitamin deficiencies
0.000 0.403 0.597
E51 Thiamine deficiency
0.000 0.403 0.597
E50 Vitamin A deficiency
0.000 0.403 0.597
E60 Dietary zinc deficiency
0.000 0.403 0.597
E59 Dietary selenium deficiency
0.000 0.403 0.597
E58 Dietary calcium deficiency
0.000 0.403 0.597
E54 Ascorbic acid deficiency
0.000 0.403 0.597
E52 Niacin deficiency [pellagra]
0.000 0.403 0.597
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.407 0.593
I49.0 Ventricular fibrillation and flutter
0.000 0.410 0.590
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.414 0.586
E34.5 Androgen resistance syndrome
0.000 0.415 0.585
E34.4 Constitutional tall stature
0.000 0.415 0.585
E34.3 Short stature, not elsewhere classified
0.000 0.415 0.585
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.415 0.585
E34.1 Other hypersecretion of intestinal hormones
0.000 0.415 0.585
E06.4 Drug-induced thyroiditis
0.000 0.423 0.576
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.423 0.576
E06.1 Subacute thyroiditis
0.000 0.423 0.576
E06.0 Acute thyroiditis
0.000 0.423 0.576
E61.1 Iron deficiency
0.000 0.424 0.576
I24.8 Other forms of acute ischaemic heart disease
0.000 0.428 0.572
E07 Other disorders of thyroid
0.000 0.430 0.570
E28.9 Ovarian dysfunction, unspecified
0.000 0.434 0.566
E28.8 Other ovarian dysfunction
0.000 0.434 0.566
E28.1 Androgen excess
0.000 0.434 0.566
E28.0 Oestrogen excess
0.000 0.434 0.566
I42 Cardiomyopathy
0.000 0.437 0.563
E40-E46 Malnutrition
0.000 0.439 0.561
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.445 0.555
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.445 0.555
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.445 0.555
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.445 0.555
I52 Other heart disorders in diseases classified elsewhere
0.000 0.451 0.549
I48 Atrial fibrillation and flutter
0.000 0.451 0.549
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.451 0.549
I41 Myocarditis in diseases classified elsewhere
0.000 0.451 0.549
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.451 0.549
I32 Pericarditis in diseases classified elsewhere
0.000 0.451 0.549
E29 Testicular dysfunction
0.000 0.453 0.546
E61.2 Magnesium deficiency
0.000 0.454 0.546
I49.2 Junctional premature depolarisation
0.000 0.457 0.543
I11 Hypertensive heart disease
0.000 0.459 0.541
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.461 0.539
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.461 0.539
E55 Vitamin D deficiency
0.000 0.461 0.539
E24 Cushing's syndrome
0.000 0.461 0.539
E53.9 Vitamin B deficiency, unspecified
0.000 0.461 0.539
I21.4 Acute subendocardial myocardial infarction
0.000 0.461 0.539
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.462 0.538
E22.8 Other hyperfunction of pituitary gland
0.000 0.462 0.538
I37 Pulmonary valve disorders
0.000 0.464 0.535
I50.9 Heart failure, unspecified
0.000 0.474 0.526
E14.3 With ophthalmic complications
0.000 0.476 0.524
I15 Secondary hypertension
0.000 0.476 0.523
I33 Acute and subacute endocarditis
0.000 0.477 0.523
E53.8 Deficiency of other specified B group vitamins
0.000 0.479 0.521
E22.1 Hyperprolactinaemia
0.000 0.479 0.521
I50.1 Left ventricular failure
0.000 0.480 0.520
E23.0 Hypopituitarism
0.000 0.483 0.517
E10.7 With multiple complications
0.000 0.485 0.515
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.486 0.514
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.514
I98.0 Cardiovascular syphilis
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.489 0.511
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.489 0.511
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.489 0.511
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.489 0.511
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.489 0.511
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.489 0.511
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.489 0.511
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.489 0.511
E30.9 Disorder of puberty, unspecified
0.000 0.493 0.506
E30.8 Other disorders of puberty
0.000 0.493 0.506
E30.1 Precocious puberty
0.000 0.493 0.506
E30.0 Delayed puberty
0.000 0.493 0.506
E31.9 Polyglandular dysfunction, unspecified
0.000 0.493 0.506
E31.8 Other polyglandular dysfunction
0.000 0.493 0.506
E31.1 Polyglandular hyperfunction
0.000 0.493 0.506
E31.0 Autoimmune polyglandular failure
0.000 0.493 0.506
E32.9 Disease of thymus, unspecified
0.000 0.493 0.506
E32.8 Other diseases of thymus
0.000 0.493 0.506
E32.1 Abscess of thymus
0.000 0.493 0.506
E32.0 Persistent hyperplasia of thymus
0.000 0.493 0.506
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.493 0.506
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.493 0.506
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.493 0.506
E06.5 Other chronic thyroiditis
0.000 0.494 0.505
E14.4 With neurological complications
0.000 0.496 0.504
I05-I09 Chronic rheumatic heart diseases
0.000 0.497 0.503
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.498 0.502
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.498 0.502
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.498 0.502
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.498 0.502
E61.9 Deficiency of nutrient element, unspecified
0.000 0.498 0.501
E61.8 Deficiency of other specified nutrient elements
0.000 0.498 0.501
E61.7 Deficiency of multiple nutrient elements
0.000 0.498 0.501
E61.6 Vanadium deficiency
0.000 0.498 0.501
E61.5 Molybdenum deficiency
0.000 0.498 0.501
E61.4 Chromium deficiency
0.000 0.498 0.501
E61.3 Manganese deficiency
0.000 0.498 0.501
E61.0 Copper deficiency
0.000 0.498 0.501
I02 Rheumatic chorea
0.000 0.499 0.501
I01 Rheumatic fever with heart involvement
0.000 0.499 0.501
I00 Rheumatic fever without mention of heart involvement
0.000 0.499 0.501
I49.4 Other and unspecified premature depolarisation
0.000 0.501 0.499
I36 Nonrheumatic tricuspid valve disorders
0.000 0.503 0.497
E13 Other specified diabetes mellitus
0.000 0.507 0.493
E12.9 Without complications
0.000 0.509 0.490
E12.8 With unspecified complications
0.000 0.509 0.490
E12.7 With multiple complications
0.000 0.509 0.490
E12.6 With other specified complications
0.000 0.509 0.490
E12.5 With peripheral circulatory complications
0.000 0.509 0.490
E12.4 With neurological complications
0.000 0.509 0.490
E12.3 With ophthalmic complications
0.000 0.509 0.490
E12.2 With renal complications
0.000 0.509 0.490
E12.1 With ketoacidosis
0.000 0.509 0.490
E12.0 With coma
0.000 0.509 0.490
E14.6 With other specified complications
0.000 0.514 0.486
E53.1 Pyridoxine deficiency
0.000 0.515 0.485
E53.0 Riboflavin deficiency
0.000 0.515 0.485
E20.8 Other hypoparathyroidism
0.000 0.518 0.482
E20.1 Pseudohypoparathyroidism
0.000 0.518 0.482
E20.0 Idiopathic hypoparathyroidism
0.000 0.518 0.482
E14.1 With ketoacidosis
0.000 0.518 0.482
I24.1 Dressler's syndrome
0.000 0.519 0.481
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.522 0.478
I35.9 Aortic valve disorder, unspecified
0.000 0.524 0.476
E15 Nondiabetic hypoglycaemic coma
0.000 0.528 0.472
E14.7 With multiple complications
0.000 0.536 0.464
E14.5 With peripheral circulatory complications
0.000 0.536 0.464
E14.2 Withrenal complications
0.000 0.536 0.464
E14.0 With coma
0.000 0.536 0.464
E25.9 Adrenogenital disorder, unspecified
0.000 0.537 0.462
E25.8 Other adrenogenital disorders
0.000 0.537 0.462
I42.9 Cardiomyopathy, unspecified
0.000 0.540 0.460
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.547 0.453
I35.8 Other aortic valve disorders
0.000 0.547 0.453
E26.8 Other hyperaldosteronism
0.000 0.551 0.449
E26.1 Secondary hyperaldosteronism
0.000 0.551 0.449
E20.9 Hypoparathyroidism, unspecified
0.000 0.551 0.448
I47.0 Reentry ventricular arrhythmia
0.000 0.563 0.436
E50.9 Vitamin A deficiency, unspecified
0.000 0.572 0.428
E50.8 Other manifestations of vitamin A deficiency
0.000 0.572 0.428
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.572 0.428
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.572 0.428
E50.5 Vitamin A deficiency with night blindness
0.000 0.572 0.428
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.572 0.428
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.572 0.428
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.572 0.428
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.572 0.428
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.572 0.428
E51.9 Thiamine deficiency, unspecified
0.000 0.572 0.428
E51.8 Other manifestations of thiamine deficiency
0.000 0.572 0.428
E51.2 Wernicke's encephalopathy
0.000 0.572 0.428
E51.1 Beriberi
0.000 0.572 0.428
E56.9 Vitamin deficiency, unspecified
0.000 0.572 0.428
E56.8 Deficiency of other vitamins
0.000 0.572 0.428
E56.1 Deficiency of vitamin K
0.000 0.572 0.428
E56.0 Deficiency of vitamin E
0.000 0.572 0.428
E63.9 Nutritional deficiency, unspecified
0.000 0.572 0.428
E63.8 Other specified nutritional deficiencies
0.000 0.572 0.428
E63.1 Imbalance of constituents of food intake
0.000 0.572 0.428
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.572 0.428
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.572 0.428
E64.8 Sequelae of other nutritional deficiencies
0.000 0.572 0.428
E64.3 Sequelae of rickets
0.000 0.572 0.428
E64.2 Sequelae of vitamin C deficiency
0.000 0.572 0.428
E64.1 Sequelae of vitamin A deficiency
0.000 0.572 0.428
E64.0 Sequelae of protein-energy malnutrition
0.000 0.572 0.428
I40 Acute myocarditis
0.000 0.573 0.427
E16 Other disorders of pancreatic internal secretion
0.000 0.577 0.423
E26.9 Hyperaldosteronism, unspecified
0.000 0.578 0.422
I42.2 Other hypertrophic cardiomyopathy
0.000 0.587 0.413
E07.1 Dyshormogenetic goitre
0.000 0.591 0.409
E07.0 Hypersecretion of calcitonin
0.000 0.591 0.409
I50.0 Congestive heart failure
0.000 0.593 0.407
I42.5 Other restrictive cardiomyopathy
0.000 0.596 0.403
I42.4 Endocardial fibroelastosis
0.000 0.596 0.403
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.596 0.403
E26.0 Primary hyperaldosteronism
0.000 0.597 0.402
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.598 0.402
E45 Retarded development following protein-energy malnutrition
0.000 0.598 0.402
E43 Unspecified severe protein-energy malnutrition
0.000 0.598 0.402
E42 Marasmic kwashiorkor
0.000 0.598 0.402
E41 Nutritional marasmus
0.000 0.598 0.402
E40 Kwashiorkor
0.000 0.598 0.402
I35.1 Aortic (valve) insufficiency
0.000 0.598 0.402
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.599 0.401
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.606 0.394
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.606 0.394
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.606 0.394
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.606 0.394
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.606 0.394
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.606 0.394
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.606 0.394
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.606 0.394
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.606 0.394
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.606 0.394
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.606 0.394
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.606 0.394
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.606 0.394
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.606 0.394
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.606 0.394
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.606 0.394
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.606 0.394
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.606 0.394
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.606 0.394
I48.4 Atypical atrial flutter
0.000 0.606 0.394
I48.3 Typical atrial flutter
0.000 0.606 0.394
I48.2 Chronic atrial fibrillation
0.000 0.606 0.394
I48.1 Persistent atrial fibrillation
0.000 0.606 0.394
I48.0 Paroxysmal atrial fibrillation
0.000 0.606 0.394
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.606 0.394
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.606 0.394
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.606 0.394
E29.9 Testicular dysfunction, unspecified
0.000 0.608 0.392
E29.8 Other testicular dysfunction
0.000 0.608 0.392
E29.0 Testicular hyperfunction
0.000 0.608 0.392
E24.0 Pituitary-dependent Cushing's disease
0.000 0.611 0.389
I42.6 Alcoholic cardiomyopathy
0.000 0.611 0.389
E55.0 Rickets, active
0.000 0.613 0.387
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.613 0.386
E24.3 Ectopic ACTH syndrome
0.000 0.613 0.386
E24.1 Nelson's syndrome
0.000 0.613 0.386
I37.9 Pulmonary valve disorder, unspecified
0.000 0.616 0.384
I37.8 Other pulmonary valve disorders
0.000 0.616 0.384
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.616 0.384
I37.0 Pulmonary valve stenosis
0.000 0.616 0.384
I05 Rheumatic mitral valve diseases
0.000 0.623 0.377
I42.0 Dilated cardiomyopathy
0.000 0.624 0.376
I15.8 Other secondary hypertension
0.000 0.624 0.375
I15.2 Hypertension secondary to endocrine disorders
0.000 0.624 0.375
I15.0 Renovascular hypertension
0.000 0.624 0.375
I33.9 Acute endocarditis, unspecified
0.000 0.625 0.375
E07.8 Other specified disorders of thyroid
0.000 0.625 0.375
I37.1 Pulmonary valve insufficiency
0.000 0.630 0.370
E24.2 Drug-induced Cushing's syndrome
0.000 0.631 0.368
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.633 0.367
E65-E68 Obesity and other hyperalimentation
0.000 0.634 0.366
I06 Rheumatic aortic valve diseases
0.000 0.639 0.361
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.641 0.359
I01.8 Other acute rheumatic heart disease
0.000 0.641 0.359
I01.2 Acute rheumatic myocarditis
0.000 0.641 0.359
I01.1 Acute rheumatic endocarditis
0.000 0.641 0.359
I01.0 Acute rheumatic pericarditis
0.000 0.641 0.359
I02.9 Rheumatic chorea without heart involvement
0.000 0.641 0.359
I02.0 Rheumatic chorea with heart involvement
0.000 0.641 0.359
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.643 0.356
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.643 0.356
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.643 0.356
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.643 0.356
I30 Acute pericarditis
0.001 0.645 0.354
E13.8 With unspecified complications
0.000 0.646 0.353
E13.7 With multiple complications
0.000 0.646 0.353
E13.6 With other specified complications
0.000 0.646 0.353
E13.5 With peripheral circulatory complications
0.000 0.646 0.353
E13.4 With neurological complications
0.000 0.646 0.353
E13.2 With renal complications
0.000 0.646 0.353
E13.1 With ketoacidosis
0.000 0.646 0.353
E13.0 With coma
0.000 0.646 0.353
E22.0 Acromegaly and pituitary gigantism
0.000 0.648 0.352
I33.0 Acute and subacute infective endocarditis
0.000 0.651 0.349
I49.1 Atrial premature depolarisation
0.000 0.652 0.348
E16.1 Other hypoglycaemia
0.000 0.652 0.348
E24.8 Other Cushing's syndrome
0.000 0.654 0.346
I49.5 Sick sinus syndrome
0.000 0.657 0.342
I12 Hypertensive renal disease
0.000 0.658 0.342
E14.8 With unspecified complications
0.000 0.665 0.334
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.669 0.331
E14.9 Without complications
0.000 0.670 0.330
I07 Rheumatic tricuspid valve diseases
0.000 0.670 0.330
E55.9 Vitamin D deficiency, unspecified
0.000 0.671 0.329
I38 Endocarditis, valve unspecified
0.000 0.674 0.326
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.676 0.324
E13.3 With ophthalmic complications
0.000 0.681 0.319
E07.9 Disorder of thyroid, unspecified
0.000 0.681 0.319
I42.8 Other cardiomyopathies
0.000 0.681 0.319
I05.0 Mitral stenosis
0.000 0.686 0.314
I15.9 Seconday hypertension, unspecified
0.001 0.689 0.310
E24.9 Cushing's syndrome, unspecified
0.000 0.692 0.308
I40.8 Other acute myocarditis
0.000 0.694 0.306
I40.1 Isolated myocarditis
0.000 0.694 0.306
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.696 0.304
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.697 0.303
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.697 0.303
E16.4 Abnormal secretion of gastrin
0.000 0.697 0.303
E16.3 Increased secretion of glucagon
0.000 0.697 0.303
I09 Other rheumatic heart diseases
0.000 0.699 0.300
I15.1 Hypertension secondary to other renal disorders
0.000 0.702 0.297
I05.2 Mitral stenosis with insufficiency
0.000 0.707 0.293
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.709 0.290
I40.9 Acute myocarditis, unspecified
0.001 0.711 0.289
E44.1 Mild protein-energy malnutrition
0.000 0.711 0.288
E44.0 Moderate protein-energy malnutrition
0.000 0.711 0.288
I08 Multiple valve diseases
0.000 0.718 0.282
I05.8 Other mitral valve diseases
0.000 0.729 0.270
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.733 0.266
I20.1 Angina pectoris with documented spasm
0.000 0.734 0.265
E67 Other hyperalimentation
0.000 0.737 0.262
E68 Sequelae of hyperalimentation
0.000 0.737 0.262
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.741 0.259
I06.8 Other rheumatic aortic valve diseases
0.000 0.741 0.259
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.741 0.259
I06.1 Rheumatic aortic insufficiency
0.000 0.741 0.259
I06.0 Rheumatic aortic stenosis
0.000 0.741 0.259
I05.1 Rheumatic mitral insufficiency
0.000 0.744 0.256
E46 Unspecified protein-energy malnutrition
0.000 0.744 0.255
I31 Other diseases of pericardium
0.000 0.746 0.254
I30.8 Other forms of acute pericarditis
0.001 0.746 0.254
I30.0 Acute nonspecific idiopathic pericarditis
0.001 0.746 0.254
E16.2 Hypoglycaemia, unspecified
0.000 0.753 0.247
I30.1 Infective pericarditis
0.001 0.753 0.246
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.000 0.759 0.241
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.761 0.239
I07.9 Tricuspid valve disease, unspecified
0.000 0.763 0.237
I07.8 Other tricuspid valve diseases
0.000 0.763 0.237
I07.2 Tricuspid stenosis with insufficiency
0.000 0.763 0.237
I07.0 Tricuspid stenosis
0.000 0.763 0.237
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.766 0.234
E29.1 Testicular hypofunction
0.001 0.768 0.232
E13.9 Without complications
0.000 0.772 0.228
I95 Hypotension
0.000 0.778 0.222
I08.0 Disorders of both mitral and aortic valves
0.000 0.779 0.221
I09.8 Other specified rheumatic heart diseases
0.000 0.784 0.215
I09.2 Chronic rheumatic pericarditis
0.000 0.784 0.215
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.784 0.215
I09.0 Rheumatic myocarditis
0.000 0.784 0.215
E65 Localised adiposity
0.000 0.786 0.214
I40.0 Infective myocarditis
0.001 0.786 0.213
I85 Oesophageal varices
0.000 0.791 0.209
I05.9 Mitral valve disease, unspecified
0.000 0.793 0.207
I07.1 Tricuspid insufficiency
0.000 0.794 0.206
I45 Other conduction disorders
0.000 0.795 0.205
I46 Cardiac arrest
0.000 0.797 0.203
I08.9 Multiple valve disease, unspecified
0.000 0.798 0.202
I86 Varicose veins of other sites
0.000 0.799 0.201
I60-I69 Cerebrovascular diseases
0.000 0.803 0.197
I12.9 Hypertensive renal disease without renal failure
0.000 0.805 0.195
I08.8 Other multiple valve diseases
0.000 0.806 0.194
I86.4 Gastric varices
0.000 0.806 0.194
E04 Other non-toxic goitre
0.000 0.806 0.193
I28 Other diseases of pulmonary vessels
0.001 0.809 0.191
I85.0 Oesophageal varices with bleeding
0.000 0.809 0.191
I31.1 Chronic constrictive pericarditis
0.000 0.810 0.190
E67.8 Other specified hyperalimentation
0.000 0.811 0.188
E67.3 Hypervitaminosis D
0.000 0.811 0.188
E67.2 Megavitamin-B6 syndrome
0.000 0.811 0.188
E67.1 Hypercarotenaemia
0.000 0.811 0.188
E67.0 Hypervitaminosis A
0.000 0.811 0.188
I80 Phlebitis and thrombophlebitis
0.000 0.812 0.188
I31.0 Chronic adhesive pericarditis
0.000 0.813 0.187
I20.0 Unstable angina
0.000 0.813 0.187
I95.2 Hypotension due to drugs
0.000 0.814 0.186
I64 Stroke, not specified as haemorrhage or infarction
0.000 0.816 0.184

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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