TreeWAS – Variant ID: rs6693017

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I30-I52 Other forms of heart disease	0.988	0.012	0.000
I44 Atrioventricular and left bundle-branch block	0.986	0.014	0.000
I50 Heart failure	0.973	0.027	0.000
I50.0 Congestive heart failure	0.971	0.029	0.000
I35 Nonrheumatic aortic valve disorders	0.970	0.030	0.000
I35.1 Aortic (valve) insufficiency	0.959	0.041	0.000
I44.0 Atrioventricular block, first degree	0.957	0.043	0.000
I47 Paroxysmal tachycardia	0.956	0.044	0.000
I45 Other conduction disorders	0.951	0.049	0.000
I44.3 Other and unspecified atrioventricular block	0.920	0.080	0.000
I47.1 Supraventricular tachycardia	0.910	0.090	0.000
I47.2 Ventricular tachycardia	0.888	0.112	0.000
I34 Nonrheumatic mitral valve disorders	0.859	0.141	0.000
I44.7 Left bundle-branch block, unspecified	0.849	0.151	0.000
I45.3 Trifascicular block	0.849	0.151	0.000
I37 Pulmonary valve disorders	0.830	0.170	0.000
I35.2 Aortic (valve) stenosis with insufficiency	0.799	0.201	0.000
I45.5 Other specified heart block	0.796	0.204	0.000
I45.2 Bifascicular block	0.791	0.209	0.000
I49 Other cardiac arrhythmias	0.789	0.211	0.000
I44.2 Atrioventricular block, complete	0.787	0.213	0.000
I44.6 Other and unspecified fascicular block	0.784	0.216	0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified	0.780	0.220	0.000
I44.1 Atrioventricular block, second degree	0.772	0.228	0.000
I45.6 Preexcitation syndrome	0.770	0.230	0.000
I38 Endocarditis, valve unspecified	0.769	0.231	0.000
I45.4 Nonspecific intraventricular block	0.760	0.240	0.000
I36 Nonrheumatic tricuspid valve disorders	0.754	0.246	0.000
I35.0 Aortic (valve) stenosis	0.752	0.248	0.000
I34.0 Mitral (valve) insufficiency	0.728	0.272	0.000
I45.1 Other and unspecified right bundle-branch block	0.725	0.275	0.000
I37.1 Pulmonary valve insufficiency	0.717	0.283	0.000
I52 Other heart disorders in diseases classified elsewhere	0.708	0.292	0.000
I48 Atrial fibrillation and flutter	0.708	0.292	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.708	0.292	0.000
I41 Myocarditis in diseases classified elsewhere	0.708	0.292	0.000
I40 Acute myocarditis	0.708	0.292	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.708	0.292	0.000
I32 Pericarditis in diseases classified elsewhere	0.708	0.292	0.000
I44.5 Left posterior fascicular block	0.707	0.293	0.000
I44.4 Left anterior fascicular block	0.707	0.293	0.000
I30 Acute pericarditis	0.686	0.314	0.000
I45.0 Right fascicular block	0.682	0.318	0.000
I49.5 Sick sinus syndrome	0.674	0.326	0.000
I49.0 Ventricular fibrillation and flutter	0.663	0.337	0.000
I50.1 Left ventricular failure	0.651	0.349	0.000
I34.2 Nonrheumatic mitral (valve) stenosis	0.630	0.370	0.000
I49.3 Ventricular premature depolarisation	0.620	0.380	0.000
I34.8 Other nonrheumatic mitral valve disorders	0.616	0.384	0.000
I47.0 Reentry ventricular arrhythmia	0.612	0.388	0.000
I35.8 Other aortic valve disorders	0.610	0.390	0.000
I37.9 Pulmonary valve disorder, unspecified	0.595	0.405	0.000
I37.8 Other pulmonary valve disorders	0.595	0.405	0.000
I37.2 Pulmonary valve stenosis with insufficiency	0.595	0.405	0.000
I37.0 Pulmonary valve stenosis	0.595	0.405	0.000
I45.8 Other specified conduction disorders	0.591	0.409	0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency	0.587	0.413	0.000
I45.9 Conduction disorder, unspecified	0.581	0.419	0.000
I49.2 Junctional premature depolarisation	0.566	0.434	0.000
I49.8 Other specified cardiac arrhythmias	0.550	0.450	0.000
I36.9 Nonrheumatic tricuspid valve disorder, unspecified	0.541	0.459	0.000
I36.8 Other nonrheumatic tricuspid valve disorders	0.541	0.459	0.000
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency	0.541	0.459	0.000
I36.0 Nonrheumatic tricuspid (valve) stenosis	0.541	0.459	0.000
I49.1 Atrial premature depolarisation	0.539	0.461	0.000
I47.9 Paroxysmal tachycardia, unspecified	0.522	0.478	0.000
I30.1 Infective pericarditis	0.517	0.483	0.000
I32.8 Pericarditis in other diseases classified elsewhere	0.508	0.492	0.000
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere	0.508	0.492	0.000
I32.0 Pericarditis in bacterial diseases classified elsewhere	0.508	0.492	0.000
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere	0.508	0.492	0.000
I39.4 Multiple valve disorders in diseases classified elsewhere	0.508	0.492	0.000
I39.3 Pulmonary valve disorders in diseases classified elsewhere	0.508	0.492	0.000
I39.2 Tricuspid valve disorders in diseases classified elsewhere	0.508	0.492	0.000
I39.1 Aortic valve disorders in diseases classified elsewhere	0.508	0.492	0.000
I39.0 Mitral valve disorders in diseases classified elsewhere	0.508	0.492	0.000
I40.9 Acute myocarditis, unspecified	0.508	0.492	0.000
I40.8 Other acute myocarditis	0.508	0.492	0.000
I40.1 Isolated myocarditis	0.508	0.492	0.000
I40.0 Infective myocarditis	0.508	0.492	0.000
I41.8 Myocarditis in other diseases classified elsewhere	0.508	0.492	0.000
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere	0.508	0.492	0.000
I41.1 Myocarditis in viral diseases classified elsewhere	0.508	0.492	0.000
I41.0 Myocarditis in bacterial diseases classified elsewhere	0.508	0.492	0.000
I43.8 Cardiomyopathy in other diseases classified elsewhere	0.508	0.492	0.000
I43.2 Cardiomyopathy in nutritional diseases	0.508	0.492	0.000
I43.1 Cardiomyopathy in metabolic diseases	0.508	0.492	0.000
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere	0.508	0.492	0.000
I48.9 Atrial fibrillation and atrial flutter, unspecified	0.508	0.492	0.000
I48.4 Atypical atrial flutter	0.508	0.492	0.000
I48.3 Typical atrial flutter	0.508	0.492	0.000
I48.2 Chronic atrial fibrillation	0.508	0.492	0.000
I48.1 Persistent atrial fibrillation	0.508	0.492	0.000
I48.0 Paroxysmal atrial fibrillation	0.508	0.492	0.000
I52.8 Other heart disorders in other diseases classified elsewhere	0.508	0.492	0.000
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere	0.508	0.492	0.000
I52.0 Other heart disorders in bacterial diseases classified elsewhere	0.508	0.492	0.000
I33 Acute and subacute endocarditis	0.492	0.507	0.001
I30.8 Other forms of acute pericarditis	0.492	0.508	0.000
I30.0 Acute nonspecific idiopathic pericarditis	0.492	0.508	0.000
I42 Cardiomyopathy	0.488	0.512	0.000
I35.9 Aortic valve disorder, unspecified	0.464	0.536	0.000
I49.9 Cardiac arrhythmia, unspecified	0.451	0.549	0.000
I42.2 Other hypertrophic cardiomyopathy	0.451	0.549	0.000
I46 Cardiac arrest	0.445	0.554	0.000
I30.9 Acute pericarditis, unspecified	0.438	0.562	0.000
I49.4 Other and unspecified premature depolarisation	0.432	0.567	0.000
I33.9 Acute endocarditis, unspecified	0.353	0.646	0.001
I42.7 Cardiomyopathy due to drugs and other external agents	0.350	0.650	0.000
I42.5 Other restrictive cardiomyopathy	0.350	0.650	0.000
I42.4 Endocardial fibroelastosis	0.350	0.650	0.000
I42.3 Endomyocardial (eosinophilic) disease	0.350	0.650	0.000
I42.6 Alcoholic cardiomyopathy	0.321	0.679	0.000
I46.1 Sudden cardiac death, so described	0.319	0.680	0.000
I42.1 Obstructive hypertrophic cardiomyopathy	0.315	0.685	0.000
I31 Other diseases of pericardium	0.314	0.685	0.000
I34.1 Mitral (valve) prolapse	0.294	0.705	0.000
I42.8 Other cardiomyopathies	0.293	0.707	0.000
I46.9 Cardiac arrest, unspecified	0.264	0.736	0.000
I42.0 Dilated cardiomyopathy	0.238	0.762	0.000
I31.8 Other specified diseases of pericardium	0.225	0.774	0.000
I31.2 Haemopericardium, not elsewhere classified	0.225	0.774	0.000
I31.1 Chronic constrictive pericarditis	0.225	0.774	0.000
I31.0 Chronic adhesive pericarditis	0.225	0.774	0.000
I51 Complications and ill-defined descriptions of heart disease	0.222	0.778	0.000
I51.6 Cardiovascular disease, unspecified	0.176	0.823	0.000
I46.0 Cardiac arrest with successful resuscitation	0.175	0.825	0.000
I50.9 Heart failure, unspecified	0.167	0.833	0.000
I51.0 Cardiac septal defect, acquired	0.160	0.839	0.000
I51.5 Myocardial degeneration	0.159	0.841	0.000
I51.2 Rupture of papillary muscle, not elsewhere classified	0.159	0.841	0.000
I51.4 Myocarditis, unspecified	0.159	0.841	0.000
I42.9 Cardiomyopathy, unspecified	0.153	0.847	0.000
I51.3 Intracardiac thrombosis, not elsewhere classified	0.152	0.848	0.000
I51.9 Heart disease, unspecified	0.151	0.849	0.000
I33.0 Acute and subacute infective endocarditis	0.137	0.861	0.002
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.133	0.867	0.000
I31.3 Pericardial effusion (noninflammatory)	0.113	0.887	0.000
I31.9 Disease of pericardium, unspecified	0.101	0.898	0.000
I51.7 Cardiomegaly	0.079	0.921	0.000
I51.8 Other ill-defined heart diseases	0.034	0.966	0.000
Z92.1 Personal history of long-term (current) use of anticoagulants	0.028	0.972	0.000
C81.9 Hodgkin's disease, unspecified	0.026	0.974	0.000
M47.92 Spondylosis, unspecified (Cervical region)	0.000	0.975	0.025
M47.9 Spondylosis, unspecified	0.000	0.981	0.019
M47.99 Spondylosis, unspecified (Site unspecified)	0.000	0.982	0.018
C81 Hodgkin's disease	0.018	0.982	0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)	0.000	0.984	0.016
C81.1 Nodular sclerosis	0.015	0.985	0.000
C81.2 Mixed cellularity	0.014	0.986	0.000
M47.95 Spondylosis, unspecified (Thoracolumbar region)	0.000	0.986	0.014
M47.94 Spondylosis, unspecified (Thoracic region)	0.000	0.986	0.014
M47.93 Spondylosis, unspecified (Cervicothoracic region)	0.000	0.986	0.014
M47.91 Spondylosis, unspecified (Occipito-atlanto-axial region)	0.000	0.986	0.014
C81.0 Lymphocytic predominance	0.013	0.987	0.000
C55 Malignant neoplasm of uterus, part unspecified	0.000	0.987	0.013
C81.7 Other Hodgkin's disease	0.013	0.987	0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma	0.013	0.987	0.000
C81.3 Lymphocytic depletion	0.013	0.987	0.000
M47.98 Spondylosis, unspecified (Sacral and sacrococcygeal region)	0.000	0.988	0.012
C56 Malignant neoplasm of ovary	0.000	0.988	0.012
M47.90 Spondylosis, unspecified (Multiple sites in spine)	0.000	0.988	0.012
C51-C58 Malignant neoplasms of female genital organs	0.000	0.988	0.012
M47 Spondylosis	0.000	0.989	0.011
I98.2 Oesophageal varices in diseases classified elsewhere	0.011	0.989	0.000
Q61.2 Polycystic kidney, adult type	0.011	0.989	0.000
M47.2 Other spondylosis with radiculopathy	0.000	0.989	0.011
Q61.3 Polycystic kidney, unspecified	0.010	0.990	0.000
C53 Malignant neoplasm of cervix uteri	0.000	0.990	0.010
Q61 Cystic kidney disease	0.010	0.990	0.000
Chapter IX Diseases of the circulatory system	0.010	0.990	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.010	0.990	0.000
M47.22 Other spondylosis with radiculopathy (Cervical region)	0.000	0.991	0.009
C52 Malignant neoplasm of vagina	0.000	0.991	0.009
I95-I99 Other and unspecified disorders of the circulatory system	0.009	0.991	0.000
M47.26 Other spondylosis with radiculopathy (Lumbar region)	0.000	0.991	0.009
C58 Malignant neoplasm of placenta	0.000	0.991	0.008
M47.0 Anterior spinal and vertebral artery compression syndromes	0.000	0.992	0.008
C51 Malignant neoplasm of vulva	0.000	0.992	0.008
C54 Malignant neoplasm of corpus uteri	0.000	0.992	0.008
M47.8 Other spondylosis	0.000	0.992	0.008
C53.9 Cervix uteri, unspecified	0.000	0.992	0.008
C57 Malignant neoplasm of other and unspecified female genital organs	0.000	0.992	0.008
M47.27 Other spondylosis with radiculopathy (Lumbosacral region)	0.000	0.992	0.008
M47.29 Other spondylosis with radiculopathy (Site unspecified)	0.000	0.992	0.008
M47.28 Other spondylosis with radiculopathy (Sacral and sacrococcygeal region)	0.000	0.992	0.008
M47.25 Other spondylosis with radiculopathy (Thoracolumbar region)	0.000	0.992	0.008
M47.24 Other spondylosis with radiculopathy (Thoracic region)	0.000	0.992	0.008
M47.23 Other spondylosis with radiculopathy (Cervicothoracic region)	0.000	0.992	0.008
M47.21 Other spondylosis with radiculopathy (Occipito-atlanto-axial region)	0.000	0.992	0.008
M47.20 Other spondylosis with radiculopathy (Multiple sites in spine)	0.000	0.992	0.008
C53.0 Endocervix	0.000	0.992	0.008
Q60-Q64 Congenital malformations of the urinary system	0.007	0.993	0.000
I05-I09 Chronic rheumatic heart diseases	0.007	0.993	0.000
M47.1 Other spondylosis with myelopathy	0.000	0.993	0.007
C53.8 Overlapping lesion of cervix uteri	0.000	0.993	0.007
C53.1 Exocervix	0.000	0.993	0.007
Q61.9 Cystic kidney disease, unspecified	0.007	0.993	0.000
Q61.8 Other cystic kidney diseases	0.007	0.993	0.000
Q61.4 Renal dysplasia	0.007	0.993	0.000
Q61.1 Polycystic kidney, infantile type	0.007	0.993	0.000
M47.86 Other spondylosis (Lumbar region)	0.000	0.993	0.007
I00-I02 Acute rheumatic fever	0.007	0.993	0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere	0.007	0.993	0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere	0.007	0.993	0.000
I98.0 Cardiovascular syphilis	0.007	0.993	0.000
Q61.5 Medullary cystic kidney	0.007	0.993	0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.007	0.993	0.000
I09 Other rheumatic heart diseases	0.007	0.993	0.000
I09.9 Rheumatic heart disease, unspecified	0.007	0.993	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.007	0.993	0.000
M47.87 Other spondylosis (Lumbosacral region)	0.000	0.993	0.007
C54.1 Endometrium	0.000	0.993	0.007
Q60 Renal agenesis and other reduction defects of kidney	0.006	0.993	0.000
M47.09 Anterior spinal and vertebral artery compression syndromes (Site unspecified)	0.000	0.994	0.006
M47.08 Anterior spinal and vertebral artery compression syndromes (Sacral and sacrococcygeal region)	0.000	0.994	0.006
M47.07 Anterior spinal and vertebral artery compression syndromes (Lumbosacral region)	0.000	0.994	0.006
M47.06 Anterior spinal and vertebral artery compression syndromes (Lumbar region)	0.000	0.994	0.006
M47.05 Anterior spinal and vertebral artery compression syndromes (Thoracolumbar region)	0.000	0.994	0.006
M47.04 Anterior spinal and vertebral artery compression syndromes (Thoracic region)	0.000	0.994	0.006
M47.03 Anterior spinal and vertebral artery compression syndromes (Cervicothoracic region)	0.000	0.994	0.006
M47.02 Anterior spinal and vertebral artery compression syndromes (Cervical region)	0.000	0.994	0.006
M47.01 Anterior spinal and vertebral artery compression syndromes (Occipito-atlanto-axial region)	0.000	0.994	0.006
M47.00 Anterior spinal and vertebral artery compression syndromes (Multiple sites in spine)	0.000	0.994	0.006
C51.8 Overlapping lesion of vulva	0.000	0.994	0.006
C51.2 Clitoris	0.000	0.994	0.006
C51.1 Labium minus	0.000	0.994	0.006
C51.0 Labium majus	0.000	0.994	0.006
C54.8 Overlapping lesion of corpus uteri	0.000	0.994	0.006
C54.3 Fundus uteri	0.000	0.994	0.006
C54.2 Myometrium	0.000	0.994	0.006
C54.0 Isthmus uteri	0.000	0.994	0.006
M47.83 Other spondylosis (Cervicothoracic region)	0.000	0.994	0.006
M47.81 Other spondylosis (Occipito-atlanto-axial region)	0.000	0.994	0.006
M47.80 Other spondylosis (Multiple sites in spine)	0.000	0.994	0.006
I07 Rheumatic tricuspid valve diseases	0.006	0.994	0.000
C57.9 Female genital organ, unspecified	0.000	0.994	0.006
C57.8 Overlapping lesion of female genital organs	0.000	0.994	0.006
C57.7 Other specified female genital organs	0.000	0.994	0.006
C57.4 Uterine adnexa, unspecified	0.000	0.994	0.006
C57.3 Parametrium	0.000	0.994	0.006
C57.2 Round ligament	0.000	0.994	0.006
C57.1 Broad ligament	0.000	0.994	0.006
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.006	0.994	0.000
I27 Other pulmonary heart diseases	0.006	0.994	0.000
M47.89 Other spondylosis (Site unspecified)	0.000	0.994	0.006
C51.9 Vulva, unspecified	0.000	0.994	0.006
M47.84 Other spondylosis (Thoracic region)	0.000	0.994	0.006
M47.88 Other spondylosis (Sacral and sacrococcygeal region)	0.000	0.994	0.006
M47.85 Other spondylosis (Thoracolumbar region)	0.000	0.994	0.006
Q60.0 Renal agenesis, unilateral	0.006	0.994	0.000
I61.9 Intracerebral haemorrhage, unspecified	0.006	0.994	0.000
C57.0 Fallopian tube	0.000	0.994	0.005
I06 Rheumatic aortic valve diseases	0.005	0.994	0.000
Q64 Other congenital malformations of urinary system	0.005	0.994	0.000
M47.19 Other spondylosis with myelopathy (Site unspecified)	0.000	0.994	0.005
M47.18 Other spondylosis with myelopathy (Sacral and sacrococcygeal region)	0.000	0.994	0.005
M47.17 Other spondylosis with myelopathy (Lumbosacral region)	0.000	0.994	0.005
M47.15 Other spondylosis with myelopathy (Thoracolumbar region)	0.000	0.994	0.005
M47.14 Other spondylosis with myelopathy (Thoracic region)	0.000	0.994	0.005
M47.13 Other spondylosis with myelopathy (Cervicothoracic region)	0.000	0.994	0.005
M47.11 Other spondylosis with myelopathy (Occipito-atlanto-axial region)	0.000	0.994	0.005
M47.10 Other spondylosis with myelopathy (Multiple sites in spine)	0.000	0.994	0.005
C54.9 Corpus uteri, unspecified	0.000	0.994	0.005
I95 Hypotension	0.005	0.994	0.000
I02 Rheumatic chorea	0.005	0.995	0.000
I01 Rheumatic fever with heart involvement	0.005	0.995	0.000
I00 Rheumatic fever without mention of heart involvement	0.005	0.995	0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter	0.005	0.995	0.000
I27.8 Other specified pulmonary heart diseases	0.005	0.995	0.000
Q44.6 Cystic disease of liver	0.005	0.995	0.000
Q63 Other congenital malformations of kidney	0.005	0.995	0.000
I27.0 Primary pulmonary hypertension	0.005	0.995	0.000
I07.1 Tricuspid insufficiency	0.005	0.995	0.000
I09.8 Other specified rheumatic heart diseases	0.005	0.995	0.000
I09.2 Chronic rheumatic pericarditis	0.005	0.995	0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified	0.005	0.995	0.000
I09.0 Rheumatic myocarditis	0.005	0.995	0.000
I27.9 Pulmonary heart disease, unspecified	0.005	0.995	0.000
I99 Other and unspecified disorders of circulatory system	0.005	0.995	0.000
I95.1 Orthostatic hypotension	0.005	0.995	0.000
M47.12 Other spondylosis with myelopathy (Cervical region)	0.000	0.995	0.005
Q61.0 Congenital single renal cyst	0.005	0.995	0.000
M47.16 Other spondylosis with myelopathy (Lumbar region)	0.000	0.995	0.005
Q60.2 Renal agenesis, unspecified	0.005	0.995	0.000
I10-I15 Hypertensive diseases	0.005	0.995	0.000
Q60.6 Potter's syndrome	0.005	0.995	0.000
Q60.5 Renal hypoplasia, unspecified	0.005	0.995	0.000
Q60.4 Renal hypoplasia, bilateral	0.005	0.995	0.000
Q60.3 Renal hypoplasia, unilateral	0.005	0.995	0.000
Q60.1 Renal agenesis, bilateral	0.005	0.995	0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.005	0.995	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.000	0.995	0.005
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.005	0.995	0.000
I28 Other diseases of pulmonary vessels	0.005	0.995	0.000
M47.82 Other spondylosis (Cervical region)	0.000	0.995	0.005
I07.9 Tricuspid valve disease, unspecified	0.005	0.995	0.000
I07.8 Other tricuspid valve diseases	0.005	0.995	0.000
I07.2 Tricuspid stenosis with insufficiency	0.005	0.995	0.000
I07.0 Tricuspid stenosis	0.005	0.995	0.000
M84.03 Malunion of fracture (Forearm)	0.005	0.995	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.005	0.995	0.000
I97.2 Postmastectomy lymphoedema syndrome	0.005	0.995	0.000
I97.9 Postprocedural disorder of circulatory system, unspecified	0.004	0.995	0.000
I97.0 Postcardiotomy syndrome	0.004	0.995	0.000
I27.1 Kyphoscoliotic heart disease	0.004	0.995	0.000
I97.1 Other functional disturbances following cardiac surgery	0.004	0.995	0.000
Q63.1 Lobulated, fused and horseshoe kidney	0.005	0.995	0.000
M84.0 Malunion of fracture	0.004	0.996	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.004	0.996	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.004	0.996	0.000
S00.1 Contusion of eyelid and periocular area	0.004	0.996	0.000
I06.9 Rheumatic aortic valve disease, unspecified	0.004	0.996	0.000
I06.8 Other rheumatic aortic valve diseases	0.004	0.996	0.000
I06.2 Rheumatic aortic stenosis with insufficiency	0.004	0.996	0.000
I06.1 Rheumatic aortic insufficiency	0.004	0.996	0.000
I06.0 Rheumatic aortic stenosis	0.004	0.996	0.000
Q64.9 Congenital malformation of urinary system, unspecified	0.004	0.996	0.000
Q64.8 Other specified congenital malformations of urinary system	0.004	0.996	0.000
Q64.7 Other congenital malformations of bladder and urethra	0.004	0.996	0.000
Q64.6 Congenital diverticulum of bladder	0.004	0.996	0.000
Q64.5 Congenital absence of bladder and urethra	0.004	0.996	0.000
Q64.4 Malformation of urachus	0.004	0.996	0.000
Q64.3 Other atresia and stenosis of urethra and bladder neck	0.004	0.996	0.000
Q64.2 Congenital posterior urethral valves	0.004	0.996	0.000
Q64.1 Exstrophy of urinary bladder	0.004	0.996	0.000
Q64.0 Epispadias	0.004	0.996	0.000
I11 Hypertensive heart disease	0.004	0.996	0.000
Q62.8 Other congenital malformations of ureter	0.004	0.996	0.000
Q62.7 Congenital vesico-uretero-renal reflux	0.004	0.996	0.000
Q62.6 Malposition of ureter	0.004	0.996	0.000
Q62.4 Agenesis of ureter	0.004	0.996	0.000
Q62.3 Other obstructive defects of renal pelvis and ureter	0.004	0.996	0.000
Q62.2 Congenital megaloureter	0.004	0.996	0.000
Q62.1 Atresia and stenosis of ureter	0.004	0.996	0.000
Q62.0 Congenital hydronephrosis	0.004	0.996	0.000
I01.9 Acute rheumatic heart disease, unspecified	0.004	0.996	0.000
I01.8 Other acute rheumatic heart disease	0.004	0.996	0.000
I01.2 Acute rheumatic myocarditis	0.004	0.996	0.000
I01.1 Acute rheumatic endocarditis	0.004	0.996	0.000
I01.0 Acute rheumatic pericarditis	0.004	0.996	0.000
I02.9 Rheumatic chorea without heart involvement	0.004	0.996	0.000
I02.0 Rheumatic chorea with heart involvement	0.004	0.996	0.000
M84 Disorders of continuity of bone	0.004	0.996	0.000
Q21 Congenital malformations of cardiac septa	0.004	0.996	0.000
Q63.9 Congenital malformation of kidney, unspecified	0.004	0.996	0.000
Q63.8 Other specified congenital malformations of kidney	0.004	0.996	0.000
Q63.3 Hyperplastic and giant kidney	0.004	0.996	0.000
Q63.2 Ectopic kidney	0.004	0.996	0.000
S00.5 Superficial injury of lip and oral cavity	0.004	0.996	0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.004	0.996	0.000
Q62.5 Duplication of ureter	0.004	0.996	0.000
Q44.5 Other congenital malformations of bile ducts	0.004	0.996	0.000
S00.8 Superficial injury of other parts of head	0.004	0.996	0.000
M35.3 Polymyalgia rheumatica	0.000	0.996	0.004
I11.0 Hypertensive heart disease with (congestive) heart failure	0.004	0.996	0.000
I05 Rheumatic mitral valve diseases	0.004	0.996	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.004	0.996	0.000
I08 Multiple valve diseases	0.004	0.996	0.000
I12 Hypertensive renal disease	0.004	0.996	0.000
I12.0 Hypertensive renal disease with renal failure	0.004	0.996	0.000
S00 Superficial injury of head	0.004	0.996	0.000
I95.8 Other hypotension	0.004	0.996	0.000
I13 Hypertensive heart and renal disease	0.004	0.996	0.000
M84.01 Malunion of fracture (Shoulder region)	0.004	0.996	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.004	0.996	0.000
M84.02 Malunion of fracture (Upper arm)	0.004	0.996	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.004	0.996	0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.004	0.996	0.000
Q21.1 Atrial septal defect	0.004	0.996	0.000
Q44.7 Other congenital malformations of liver	0.004	0.996	0.000
Q44.4 Choledochal cyst	0.004	0.996	0.000
Q44.3 Congenital stenosis and stricture of bile ducts	0.004	0.996	0.000
Q44.2 Atresia of bile ducts	0.004	0.996	0.000
Q44.1 Other congenital malformations of gallbladder	0.004	0.996	0.000
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder	0.004	0.996	0.000
S00.3 Superficial injury of nose	0.004	0.996	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.004	0.996	0.000
Q80-Q89 Other congenital malformations	0.004	0.996	0.000
I28.9 Disease of pulmonary vessels, unspecified	0.003	0.996	0.000
I28.1 Aneurysm of pulmonary artery	0.003	0.996	0.000
I28.0 Arteriovenous fistula of pulmonary vessels	0.003	0.996	0.000
I95.0 Idiopathic hypotension	0.004	0.996	0.000
Q21.9 Congenital malformation of cardiac septum, unspecified	0.004	0.996	0.000
M84.4 Pathological fracture, not elsewhere classified	0.004	0.996	0.000
M84.15 Nonunion of fracture [pseudarthrosis] (Pelvic region and thigh)	0.004	0.996	0.000
Q35-Q37 Cleft lip and cleft palate	0.004	0.996	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.004	0.996	0.000
S00.4 Superficial injury of ear	0.004	0.996	0.000
Q21.3 Tetralogy of Fallot	0.003	0.996	0.000
I15 Secondary hypertension	0.003	0.996	0.000
Q24 Other congenital malformations of heart	0.003	0.996	0.000
M84.09 Malunion of fracture (Site unspecified)	0.003	0.997	0.000
M84.08 Malunion of fracture (Other)	0.003	0.997	0.000
M84.05 Malunion of fracture (Pelvic region and thigh)	0.003	0.997	0.000
M84.00 Malunion of fracture (Multiple sites)	0.003	0.997	0.000
I28.8 Other specified diseases of pulmonary vessels	0.003	0.997	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.003	0.997	0.000
M84.07 Malunion of fracture (Ankle and foot)	0.003	0.997	0.000
I95.9 Hypotension, unspecified	0.003	0.997	0.000
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.003	0.997	0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.003	0.997	0.000
Q45 Other congenital malformations of digestive system	0.003	0.997	0.000
Q42 Congenital absence, atresia and stenosis of large intestine	0.003	0.997	0.000
Q41 Congenital absence, atresia and stenosis of small intestine	0.003	0.997	0.000
Q40 Other congenital malformations of upper alimentary tract	0.003	0.997	0.000
I61 Intracerebral haemorrhage	0.003	0.997	0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.003	0.997	0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified	0.003	0.997	0.000
M84.48 Pathological fracture, not elsewhere classified (Other)	0.003	0.997	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.003	0.997	0.000
M84.06 Malunion of fracture (Lower leg)	0.003	0.997	0.000
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.003	0.997	0.000
Q00-Q07 Congenital malformations of the nervous system	0.003	0.997	0.000
C91.0 Acute lymphoblastic leukaemia	0.003	0.997	0.000
I08.9 Multiple valve disease, unspecified	0.003	0.997	0.000
Q24.9 Congenital malformation of the heart, unspecified	0.003	0.997	0.000
M47.96 Spondylosis, unspecified (Lumbar region)	0.000	0.997	0.003
Q74 Other congenital malformations of limb(s)	0.003	0.997	0.000
B34.9 Viral infection, unspecified	0.003	0.997	0.000
I05.2 Mitral stenosis with insufficiency	0.003	0.997	0.000
M84.9 Disorder of continuity of bone, unspecified	0.003	0.997	0.000
M84.8 Other disorders of continuity of bone	0.003	0.997	0.000
M84.3 Stress fracture, not elsewhere classified	0.003	0.997	0.000
M84.2 Delayed union of fracture	0.003	0.997	0.000
O73.0 Retained placenta, without haemorrhage	0.003	0.997	0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.003	0.997	0.000
I87.2 Venous insufficiency (chronic) (peripheral)	0.003	0.997	0.000
Q21.8 Other congenital malformations of cardiac septa	0.003	0.997	0.000
Q21.4 Aortopulmonary septal defect	0.003	0.997	0.000
Q21.2 Atrioventricular septal defect	0.003	0.997	0.000
I95.2 Hypotension due to drugs	0.003	0.997	0.000
I05.1 Rheumatic mitral insufficiency	0.003	0.997	0.000
O73.1 Retained portions of placenta and membranes, without haemorrhage	0.003	0.997	0.000
Q21.0 Ventricular septal defect	0.003	0.997	0.000
I05.8 Other mitral valve diseases	0.003	0.997	0.000
C91 Lymphoid leukaemia	0.003	0.997	0.000
Q26 Congenital malformations of great veins	0.003	0.997	0.000
Q25 Congenital malformations of great arteries	0.003	0.997	0.000
Q22 Congenital malformations of pulmonary and tricuspid valves	0.003	0.997	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.003	0.997	0.000
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.003	0.997	0.000
Q43 Other congenital malformations of intestine	0.003	0.997	0.000
I08.0 Disorders of both mitral and aortic valves	0.003	0.997	0.000
M62.8 Other specified disorders of muscle	0.003	0.997	0.000
Q39 Congenital malformations of oesophagus	0.003	0.997	0.000
M84.04 Malunion of fracture (Hand)	0.003	0.997	0.000
I08.8 Other multiple valve diseases	0.003	0.997	0.000
Q63.0 Accessory kidney	0.003	0.997	0.000
Q78 Other osteochondrodysplasias	0.003	0.997	0.000
Q89 Other congenital malformations, not elsewhere classified	0.003	0.997	0.000
Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified	0.003	0.997	0.000
M62.80 Other specified disorders of muscle (Multiple sites)	0.003	0.997	0.000
Q27 Other congenital malformations of peripheral vascular system	0.003	0.997	0.000
I13.9 Hypertensive heart and renal disease, unspecified	0.003	0.997	0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.003	0.997	0.000
I13.1 Hypertensive heart and renal disease with renal failure	0.003	0.997	0.000
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.003	0.997	0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine	0.003	0.997	0.000
Q75 Other congenital malformations of skull and face bones	0.003	0.997	0.000
Q73 Reduction defects of unspecified limb	0.003	0.997	0.000
Q72 Reduction defects of lower limb	0.003	0.997	0.000
Q71 Reduction defects of upper limb	0.003	0.997	0.000
Q70 Syndactyly	0.003	0.997	0.000
Q69 Polydactyly	0.003	0.997	0.000
Q68 Other congenital musculoskeletal deformities	0.003	0.997	0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.003	0.997	0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical	0.003	0.997	0.000
I27.2 Other secondary pulmonary hypertension	0.003	0.997	0.000
S00.2 Other superficial injuries of eyelid and periocular area	0.003	0.997	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.003	0.997	0.000
Q66 Congenital deformities of feet	0.003	0.997	0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.003	0.997	0.000
Q84 Other congenital malformations of integument	0.003	0.997	0.000
Q81 Epidermolysis bullosa	0.003	0.997	0.000
Q80 Congenital ichthyosis	0.003	0.997	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.003	0.997	0.000
Q79.6 Ehlers-Danlos syndrome	0.003	0.997	0.000
Q99 Other chromosome abnormalities, not elsewhere classified	0.003	0.997	0.000
Q97 Other sex chromosome abnormalities, female phenotype, not elsewhere classified	0.003	0.997	0.000
Q96 Turner's syndrome	0.003	0.997	0.000
Q95 Balanced rearrangements and structural markers, not elsewhere classified	0.003	0.997	0.000
Q93 Monosomies and deletions from the autosomes, not elsewhere classified	0.003	0.997	0.000
Q92 Other trisomies and partial trisomies of the autosomes, not elsewhere classified	0.003	0.997	0.000
Q91 Edwards' syndrome and Patau's syndrome	0.003	0.997	0.000
Q90 Down's syndrome	0.003	0.997	0.000
Q50-Q56 Congenital malformations of genital organs	0.003	0.997	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.003	0.997	0.000
Q18 Other congenital malformations of face and neck	0.003	0.997	0.000
Q82 Other congenital malformations of skin	0.003	0.997	0.000
C91.5 Adult T-cell leukaemia	0.003	0.997	0.000
C91.1 Chronic lymphocytic leukaemia	0.003	0.997	0.000
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.003	0.997	0.000
M84.49 Pathological fracture, not elsewhere classified (Site unspecified)	0.003	0.997	0.000
M84.47 Pathological fracture, not elsewhere classified (Ankle and foot)	0.003	0.997	0.000
M84.46 Pathological fracture, not elsewhere classified (Lower leg)	0.003	0.997	0.000
M84.44 Pathological fracture, not elsewhere classified (Hand)	0.003	0.997	0.000
M84.43 Pathological fracture, not elsewhere classified (Forearm)	0.003	0.997	0.000
M84.42 Pathological fracture, not elsewhere classified (Upper arm)	0.003	0.997	0.000
M84.41 Pathological fracture, not elsewhere classified (Shoulder region)	0.003	0.997	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations