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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6916187
log Bayes Factor = 65.4592
Chromosome 6   position 31,463,926  (GRCh37) Explore rs6916187 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.001 0.999
M45 Ankylosing spondylitis
0.999 0.001 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.997 0.003 0.000
R31 Unspecified haematuria
0.997 0.003 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.006 0.994
E10-E14 Diabetes mellitus
0.000 0.008 0.992
E05.9 Thyrotoxicosis, unspecified
0.000 0.008 0.992
E00-E07 Disorders of thyroid gland
0.000 0.012 0.988
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.012 0.988
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.016 0.984
E10.2 With renal complications
0.000 0.024 0.976
E10.9 Without complications
0.000 0.026 0.974
I25 Chronic ischaemic heart disease
0.968 0.032 0.000
I20-I25 Ischaemic heart diseases
0.965 0.035 0.000
I20 Angina pectoris
0.964 0.036 0.000
G35 Multiple sclerosis
0.000 0.037 0.963
I25.1 Atherosclerotic heart disease
0.962 0.038 0.000
I20.0 Unstable angina
0.957 0.043 0.000
E10.3 With ophthalmic complications
0.000 0.043 0.957
M45.X2 Ankylosing spondylitis (Cervical region)
0.951 0.049 0.000
E10.1 With ketoacidosis
0.000 0.052 0.948
I24 Other acute ischaemic heart diseases
0.921 0.079 0.000
K90 Intestinal malabsorption
0.000 0.080 0.920
E20-E35 Disorders of other endocrine glands
0.000 0.083 0.917
E10.4 With neurological complications
0.000 0.084 0.916
I25.9 Chronic ischaemic heart disease, unspecified
0.916 0.084 0.000
I20.9 Angina pectoris, unspecified
0.915 0.085 0.000
E27 Other disorders of adrenal gland
0.000 0.088 0.912
K90.9 Intestinal malabsorption, unspecified
0.000 0.101 0.899
E27.1 Primary adrenocortical insufficiency
0.000 0.108 0.892
E50-E64 Other nutritional deficiencies
0.000 0.110 0.890
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.113 0.887
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.875 0.125 0.000
G37 Other demyelinating diseases of central nervous system
0.000 0.127 0.873
I25.5 Ischaemic cardiomyopathy
0.871 0.129 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.135 0.865
E05.8 Other thyrotoxicosis
0.000 0.147 0.853
E10.8 With unspecified complications
0.000 0.149 0.851
I20.1 Angina pectoris with documented spasm
0.847 0.153 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.841 0.159 0.000
I25.2 Old myocardial infarction
0.821 0.179 0.000
E10.5 With peripheral circulatory complications
0.000 0.187 0.813
E06 Thyroiditis
0.000 0.189 0.811
E10.6 With other specified complications
0.000 0.189 0.811
E27.8 Other specified disorders of adrenal gland
0.000 0.192 0.808
E11 Non-insulin-dependent diabetes mellitus
0.000 0.199 0.801
I24.8 Other forms of acute ischaemic heart disease
0.792 0.208 0.000
E53 Deficiency of other B group vitamins
0.000 0.209 0.791
E61 Deficiency of other nutrient elements
0.000 0.215 0.785
I23 Certain current complications following acute myocardial infarction
0.772 0.228 0.000
E11.5 With peripheral circulatory complications
0.000 0.233 0.767
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.233 0.767
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.236 0.764
E34 Other endocrine disorders
0.000 0.257 0.743
E20 Hypoparathyroidism
0.000 0.259 0.741
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.263 0.737
I25.8 Other forms of chronic ischaemic heart disease
0.737 0.263 0.000
E27.2 Addisonian crisis
0.000 0.264 0.736
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.266 0.734
I25.4 Coronary artery aneurysm
0.724 0.276 0.000
E06.9 Thyroiditis, unspecified
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.284 0.716
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.716 0.284 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.716 0.284 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.716 0.284 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.716 0.284 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.716 0.284 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.716 0.284 0.000
E05.5 Thyroid crisis or storm
0.000 0.287 0.713
E05.4 Thyrotoxicosis factitia
0.000 0.287 0.713
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.287 0.713
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.287 0.713
E12 Malnutrition-related diabetes mellitus
0.000 0.288 0.711
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.290 0.710
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.291 0.709
E00 Congenital iodine-deficiency syndrome
0.000 0.291 0.709
E14 Unspecified diabetes mellitus
0.000 0.293 0.707
I25.6 Silent myocardial ischaemia
0.707 0.293 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.309 0.691
E07 Other disorders of thyroid
0.000 0.316 0.684
E61.1 Iron deficiency
0.000 0.318 0.682
E40-E46 Malnutrition
0.000 0.319 0.681
I24.9 Acute ischaemic heart disease, unspecified
0.669 0.331 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.340 0.659
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.340 0.659
K90.1 Tropical sprue
0.000 0.340 0.659
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.342 0.658
E32 Diseases of thymus
0.000 0.342 0.658
E31 Polyglandular dysfunction
0.000 0.342 0.658
E30 Disorders of puberty, not elsewhere classified
0.000 0.342 0.658
E27.5 Adrenomedullary hyperfunction
0.000 0.346 0.654
E27.0 Other adrenocortical overactivity
0.000 0.346 0.654
E25 Adrenogenital disorders
0.000 0.348 0.652
K90.8 Other intestinal malabsorption
0.000 0.351 0.648
E51 Thiamine deficiency
0.000 0.358 0.642
E11.4 With neurological complications
0.000 0.360 0.640
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.361 0.639
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.362 0.638
E63 Other nutritional deficiencies
0.000 0.362 0.638
E50 Vitamin A deficiency
0.000 0.362 0.638
E60 Dietary zinc deficiency
0.000 0.362 0.638
E59 Dietary selenium deficiency
0.000 0.362 0.638
E54 Ascorbic acid deficiency
0.000 0.362 0.638
E52 Niacin deficiency [pellagra]
0.000 0.362 0.638
E10.0 With coma
0.000 0.363 0.636
I23.8 Other current complications following acute myocardial infarction
0.633 0.367 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.371 0.629
E11.6 With other specified complications
0.000 0.373 0.627
G37.5 Concentric sclerosis [Balo]
0.000 0.374 0.626
G37.4 Subacute necrotising myelitis
0.000 0.374 0.626
G37.2 Central pontine myelinolysis
0.000 0.374 0.626
G37.1 Central demyelination of corpus callosum
0.000 0.374 0.626
G37.0 Diffuse sclerosis
0.000 0.374 0.626
E11.3 With ophthalmic complications
0.000 0.377 0.623
E61.2 Magnesium deficiency
0.000 0.378 0.622
G36 Other acute disseminated demyelination
0.000 0.380 0.620
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.381 0.619
I25.3 Aneurysm of heart
0.618 0.382 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.385 0.614
E56 Other vitamin deficiencies
0.000 0.389 0.611
E34.9 Endocrine disorder, unspecified
0.000 0.393 0.607
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.399 0.601
E14.3 With ophthalmic complications
0.000 0.407 0.593
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.408 0.592
E27.9 Disorder of adrenal gland, unspecified
0.000 0.414 0.586
E06.4 Drug-induced thyroiditis
0.000 0.419 0.581
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.419 0.581
E06.1 Subacute thyroiditis
0.000 0.419 0.581
E06.0 Acute thyroiditis
0.000 0.419 0.581
E21.0 Primary hyperparathyroidism
0.000 0.422 0.578
E55 Vitamin D deficiency
0.000 0.422 0.578
E11.1 With ketoacidosis
0.000 0.424 0.576
E58 Dietary calcium deficiency
0.000 0.424 0.576
E11.7 With multiple complications
0.000 0.425 0.574
E53.1 Pyridoxine deficiency
0.000 0.433 0.567
E53.0 Riboflavin deficiency
0.000 0.433 0.567
E14.1 With ketoacidosis
0.000 0.434 0.566
E61.9 Deficiency of nutrient element, unspecified
0.000 0.437 0.563
E61.8 Deficiency of other specified nutrient elements
0.000 0.437 0.563
E61.7 Deficiency of multiple nutrient elements
0.000 0.437 0.563
E61.6 Vanadium deficiency
0.000 0.437 0.563
E61.5 Molybdenum deficiency
0.000 0.437 0.563
E61.4 Chromium deficiency
0.000 0.437 0.563
E61.3 Manganese deficiency
0.000 0.437 0.563
E61.0 Copper deficiency
0.000 0.437 0.563
E11.8 With unspecified complications
0.000 0.440 0.560
E29 Testicular dysfunction
0.000 0.441 0.559
E14.5 With peripheral circulatory complications
0.000 0.445 0.554
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.553 0.447 0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.553 0.447 0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.553 0.447 0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.553 0.447 0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.553 0.447 0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.553 0.447 0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.553 0.447 0.000
E34.8 Other specified endocrine disorders
0.000 0.454 0.546
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.455 0.545
E06.5 Other chronic thyroiditis
0.000 0.455 0.545
E13 Other specified diabetes mellitus
0.000 0.456 0.544
I24.1 Dressler's syndrome
0.541 0.459 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.541 0.459 0.000
E26 Hyperaldosteronism
0.000 0.459 0.540
E06.3 Autoimmune thyroiditis
0.000 0.460 0.540
E24 Cushing's syndrome
0.000 0.460 0.540
E34.0 Carcinoid syndrome
0.000 0.463 0.537
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.465 0.535
E34.5 Androgen resistance syndrome
0.000 0.467 0.533
E34.4 Constitutional tall stature
0.000 0.467 0.533
E34.3 Short stature, not elsewhere classified
0.000 0.467 0.533
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.467 0.533
E34.1 Other hypersecretion of intestinal hormones
0.000 0.467 0.533
E20.8 Other hypoparathyroidism
0.000 0.469 0.531
E20.1 Pseudohypoparathyroidism
0.000 0.469 0.531
E20.0 Idiopathic hypoparathyroidism
0.000 0.469 0.531
E07.9 Disorder of thyroid, unspecified
0.000 0.473 0.526
E21.4 Other specified disorders of parathyroid gland
0.000 0.474 0.526
E14.6 With other specified complications
0.000 0.474 0.526
E14.8 With unspecified complications
0.000 0.478 0.522
I22 Subsequent myocardial infarction
0.515 0.485 0.000
E12.9 Without complications
0.000 0.490 0.510
E12.8 With unspecified complications
0.000 0.490 0.510
E12.7 With multiple complications
0.000 0.490 0.510
E12.6 With other specified complications
0.000 0.490 0.510
E12.5 With peripheral circulatory complications
0.000 0.490 0.510
E12.4 With neurological complications
0.000 0.490 0.510
E12.3 With ophthalmic complications
0.000 0.490 0.510
E12.2 With renal complications
0.000 0.490 0.510
E12.1 With ketoacidosis
0.000 0.490 0.510
E12.0 With coma
0.000 0.490 0.510
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.492 0.508
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.492 0.508
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.492 0.508
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.492 0.508
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.492 0.508
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.492 0.508
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.492 0.508
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.492 0.508
E14.7 With multiple complications
0.000 0.493 0.507
E14.2 Withrenal complications
0.000 0.493 0.507
E14.0 With coma
0.000 0.493 0.507
E21.2 Other hyperparathyroidism
0.000 0.497 0.502
E07.1 Dyshormogenetic goitre
0.000 0.510 0.490
E07.0 Hypersecretion of calcitonin
0.000 0.510 0.490
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.512 0.488
E45 Retarded development following protein-energy malnutrition
0.000 0.512 0.488
E43 Unspecified severe protein-energy malnutrition
0.000 0.512 0.488
E42 Marasmic kwashiorkor
0.000 0.512 0.488
E41 Nutritional marasmus
0.000 0.512 0.488
E40 Kwashiorkor
0.000 0.512 0.488
I21 Acute myocardial infarction
0.483 0.517 0.000
E14.4 With neurological complications
0.000 0.522 0.477
I21.2 Acute transmural myocardial infarction of other sites
0.472 0.528 0.000
E30.9 Disorder of puberty, unspecified
0.000 0.528 0.471
E30.8 Other disorders of puberty
0.000 0.528 0.471
E30.1 Precocious puberty
0.000 0.528 0.471
E30.0 Delayed puberty
0.000 0.528 0.471
E31.9 Polyglandular dysfunction, unspecified
0.000 0.528 0.471
E31.8 Other polyglandular dysfunction
0.000 0.528 0.471
E31.1 Polyglandular hyperfunction
0.000 0.528 0.471
E31.0 Autoimmune polyglandular failure
0.000 0.528 0.471
E32.9 Disease of thymus, unspecified
0.000 0.528 0.471
E32.8 Other diseases of thymus
0.000 0.528 0.471
E32.1 Abscess of thymus
0.000 0.528 0.471
E32.0 Persistent hyperplasia of thymus
0.000 0.528 0.471
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.528 0.471
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.528 0.471
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.528 0.471
I22.1 Subsequent myocardial infarction of inferior wall
0.471 0.529 0.000
E25.9 Adrenogenital disorder, unspecified
0.000 0.532 0.467
E25.8 Other adrenogenital disorders
0.000 0.532 0.467
E51.2 Wernicke's encephalopathy
0.000 0.535 0.464
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.538 0.462
E46 Unspecified protein-energy malnutrition
0.000 0.539 0.461
E51.9 Thiamine deficiency, unspecified
0.000 0.539 0.460
E51.8 Other manifestations of thiamine deficiency
0.000 0.539 0.460
E51.1 Beriberi
0.000 0.539 0.460
E50.9 Vitamin A deficiency, unspecified
0.000 0.542 0.458
E50.8 Other manifestations of vitamin A deficiency
0.000 0.542 0.458
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.542 0.458
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.542 0.458
E50.5 Vitamin A deficiency with night blindness
0.000 0.542 0.458
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.542 0.458
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.542 0.458
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.542 0.458
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.542 0.458
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.542 0.458
E63.9 Nutritional deficiency, unspecified
0.000 0.542 0.458
E63.8 Other specified nutritional deficiencies
0.000 0.542 0.458
E63.1 Imbalance of constituents of food intake
0.000 0.542 0.458
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.542 0.458
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.542 0.458
E64.8 Sequelae of other nutritional deficiencies
0.000 0.542 0.458
E64.3 Sequelae of rickets
0.000 0.542 0.458
E64.2 Sequelae of vitamin C deficiency
0.000 0.542 0.458
E64.1 Sequelae of vitamin A deficiency
0.000 0.542 0.458
E64.0 Sequelae of protein-energy malnutrition
0.000 0.542 0.458
E11.2 With renal complications
0.000 0.548 0.452
G36.9 Acute disseminated demyelination, unspecified
0.000 0.555 0.445
G36.8 Other specified acute disseminated demyelination
0.000 0.555 0.445
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.555 0.445
E56.9 Vitamin deficiency, unspecified
0.000 0.562 0.438
E56.8 Deficiency of other vitamins
0.000 0.562 0.438
E56.0 Deficiency of vitamin E
0.000 0.562 0.438
E21.3 Hyperparathyroidism, unspecified
0.000 0.563 0.437
R30.0 Dysuria
0.430 0.570 0.000
G36.0 Neuromyelitis optica [Devic]
0.000 0.571 0.429
R30-R39 Symptoms and signs involving the urinary system
0.426 0.574 0.000
R30 Pain associated with micturition
0.424 0.576 0.000
E28 Ovarian dysfunction
0.000 0.582 0.418
E07.8 Other specified disorders of thyroid
0.000 0.585 0.415
E55.0 Rickets, active
0.000 0.586 0.414
E56.1 Deficiency of vitamin K
0.000 0.589 0.411
E22 Hyperfunction of pituitary gland
0.000 0.596 0.404
E29.9 Testicular dysfunction, unspecified
0.000 0.599 0.401
E29.8 Other testicular dysfunction
0.000 0.599 0.401
E29.0 Testicular hyperfunction
0.000 0.599 0.401
R34 Anuria and oliguria
0.396 0.604 0.000
E15 Nondiabetic hypoglycaemic coma
0.000 0.609 0.391
E13.8 With unspecified complications
0.000 0.609 0.390
E13.7 With multiple complications
0.000 0.609 0.390
E13.6 With other specified complications
0.000 0.609 0.390
E13.5 With peripheral circulatory complications
0.000 0.609 0.390
E13.4 With neurological complications
0.000 0.609 0.390
E13.2 With renal complications
0.000 0.609 0.390
E13.1 With ketoacidosis
0.000 0.609 0.390
E13.0 With coma
0.000 0.609 0.390
E13.3 With ophthalmic complications
0.000 0.610 0.390
E26.8 Other hyperaldosteronism
0.000 0.612 0.387
E26.1 Secondary hyperaldosteronism
0.000 0.612 0.387
E24.8 Other Cushing's syndrome
0.000 0.612 0.387
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.612 0.387
E24.3 Ectopic ACTH syndrome
0.000 0.612 0.387
E24.1 Nelson's syndrome
0.000 0.612 0.387
E24.0 Pituitary-dependent Cushing's disease
0.000 0.626 0.374
E26.9 Hyperaldosteronism, unspecified
0.000 0.628 0.371
E11.0 With coma
0.000 0.632 0.367
E24.2 Drug-induced Cushing's syndrome
0.000 0.640 0.360
E55.9 Vitamin D deficiency, unspecified
0.000 0.646 0.354
E44.1 Mild protein-energy malnutrition
0.000 0.650 0.350
E44.0 Moderate protein-energy malnutrition
0.000 0.650 0.350
I21.X Presumed acute myicardial infaction (unconfirmed)
0.346 0.654 0.000
I21.9 Acute myocardial infarction, unspecified
0.344 0.656 0.000
E24.9 Cushing's syndrome, unspecified
0.000 0.671 0.329
E65-E68 Obesity and other hyperalimentation
0.000 0.673 0.326
E23 Hypofunction and other disorders of pituitary gland
0.000 0.686 0.314
R30.1 Vesical tenesmus
0.308 0.692 0.000
E29.1 Testicular hypofunction
0.000 0.697 0.302
E28.9 Ovarian dysfunction, unspecified
0.000 0.700 0.300
E28.8 Other ovarian dysfunction
0.000 0.700 0.300
E28.1 Androgen excess
0.000 0.700 0.300
E28.0 Oestrogen excess
0.000 0.700 0.300
E03 Other hypothyroidism
0.001 0.702 0.297
E26.0 Primary hyperaldosteronism
0.000 0.704 0.296
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.710 0.289
E22.8 Other hyperfunction of pituitary gland
0.000 0.710 0.289
I22.8 Subsequent myocardial infarction of other sites
0.289 0.710 0.000
R36 Urethral discharge
0.279 0.720 0.000
E28.3 Primary ovarian failure
0.000 0.724 0.276
I21.3 Acute transmural myocardial infarction of unspecified site
0.262 0.738 0.000
E22.1 Hyperprolactinaemia
0.000 0.747 0.253
I20.8 Other forms of angina pectoris
0.242 0.757 0.000
E23.7 Disorder of pituitary gland, unspecified
0.000 0.762 0.238
E67 Other hyperalimentation
0.000 0.766 0.234
E68 Sequelae of hyperalimentation
0.000 0.766 0.234
I22.0 Subsequent myocardial infarction of anterior wall
0.227 0.773 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.773 0.227
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.775 0.225
E23.1 Drug-induced hypopituitarism
0.000 0.775 0.225
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.775 0.225
E13.9 Without complications
0.000 0.775 0.224
E22.0 Acromegaly and pituitary gigantism
0.000 0.775 0.225
E03.5 Myxoedema coma
0.001 0.786 0.213
E03.4 Atrophy of thyroid (acquired)
0.001 0.786 0.213
E03.3 Postinfectious hypothyroidism
0.001 0.786 0.213
E03.0 Congenital hypothyroidism with diffuse goitre
0.001 0.786 0.213
E03.1 Congenital hypothyroidism without goitre
0.001 0.790 0.209
E03.8 Other specified hypothyroidism
0.001 0.804 0.196
M25.55 Pain in joint (Pelvic region and thigh)
0.000 0.805 0.195
E23.2 Diabetes insipidus
0.000 0.807 0.193
R30.9 Painful micturition, unspecified
0.186 0.813 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.001 0.814 0.185
M25.54 Pain in joint (Hand)
0.000 0.816 0.184
M25.5 Pain in joint
0.000 0.817 0.183
I21.1 Acute transmural myocardial infarction of inferior wall
0.174 0.826 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.169 0.831 0.000
E67.8 Other specified hyperalimentation
0.000 0.832 0.168
E67.3 Hypervitaminosis D
0.000 0.832 0.168
E67.2 Megavitamin-B6 syndrome
0.000 0.832 0.168
E67.1 Hypercarotenaemia
0.000 0.832 0.168
E67.0 Hypervitaminosis A
0.000 0.832 0.168
M25.53 Pain in joint (Forearm)
0.000 0.836 0.164
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.837 0.163
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.837 0.163
E16.4 Abnormal secretion of gastrin
0.000 0.837 0.163
E16.3 Increased secretion of glucagon
0.000 0.837 0.163
E04 Other non-toxic goitre
0.000 0.840 0.160
M25 Other joint disorders, not elsewhere classified
0.000 0.843 0.157
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.845 0.155
M25.58 Pain in joint (Other)
0.000 0.846 0.154
E65 Localised adiposity
0.000 0.847 0.153
M25.7 Osteophyte
0.000 0.849 0.151
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.000 0.851 0.149
E23.6 Other disorders of pituitary gland
0.001 0.854 0.146
E16.1 Other hypoglycaemia
0.000 0.860 0.140
M25.71 Osteophyte (Shoulder region)
0.000 0.862 0.138
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.863 0.137
M25.64 Stiffness of joint, not elsewhere classified (Hand)
0.000 0.863 0.137
R39 Other symptoms and signs involving the urinary system
0.133 0.867 0.000
M25.9 Joint disorder, unspecified
0.000 0.868 0.132
M25.72 Osteophyte (Upper arm)
0.000 0.872 0.128
E11.9 Without complications
0.000 0.872 0.128
M25.68 Stiffness of joint, not elsewhere classified (Other)
0.000 0.873 0.127
M25.77 Osteophyte (Ankle and foot)
0.000 0.874 0.126
M25.76 Osteophyte (Lower leg)
0.000 0.874 0.125
M25.52 Pain in joint (Upper arm)
0.000 0.877 0.123
E28.2 Polycystic ovarian syndrome
0.001 0.879 0.121
M25.74 Osteophyte (Hand)
0.000 0.880 0.120
E04.0 Non-toxic diffuse goitre
0.000 0.880 0.120
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)
0.000 0.881 0.119
I21.0 Acute transmural myocardial infarction of anterior wall
0.119 0.881 0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)
0.000 0.882 0.118
E23.0 Hypopituitarism
0.000 0.882 0.118
M25.96 Joint disorder, unspecified (Lower leg)
0.000 0.883 0.117
H20.9 Iridocyclitis, unspecified
0.117 0.883 0.000
M25.0 Haemarthrosis
0.000 0.884 0.116
M25.73 Osteophyte (Forearm)
0.000 0.884 0.116
E04.8 Other specified non-toxic goitre
0.000 0.885 0.115
M25.50 Pain in joint (Multiple sites)
0.000 0.886 0.114
M25.63 Stiffness of joint, not elsewhere classified (Forearm)
0.000 0.886 0.114
M25.2 Flail joint
0.000 0.887 0.113
M25.1 Fistula of joint
0.000 0.887 0.113
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)
0.000 0.888 0.111
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)
0.000 0.890 0.110
M25.57 Pain in joint (Ankle and foot)
0.000 0.890 0.110
M25.70 Osteophyte (Multiple sites)
0.000 0.892 0.108
M25.79 Osteophyte (Site unspecified)
0.000 0.892 0.107
E16.2 Hypoglycaemia, unspecified
0.000 0.893 0.107
M25.91 Joint disorder, unspecified (Shoulder region)
0.000 0.894 0.106
M25.59 Pain in joint (Site unspecified)
0.000 0.897 0.102
M25.94 Joint disorder, unspecified (Hand)
0.000 0.899 0.101
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.000 0.900 0.100
C71 Malignant neoplasm of brain
0.097 0.903 0.000
R39.2 Extrarenal uraemia
0.095 0.904 0.000
C71.2 Temporal lobe
0.096 0.904 0.000
C71.9 Brain, unspecified
0.095 0.905 0.000
M25.98 Joint disorder, unspecified (Other)
0.000 0.905 0.095
M25.92 Joint disorder, unspecified (Upper arm)
0.000 0.905 0.095
M25.90 Joint disorder, unspecified (Multiple sites)
0.000 0.905 0.095
M25.78 Osteophyte (Other)
0.000 0.905 0.095
C71.0 Cerebrum, except lobes and ventricles
0.093 0.907 0.000
S02.40 Fracture of malar and maxillary bones (closed)
0.000 0.908 0.092
M25.99 Joint disorder, unspecified (Site unspecified)
0.000 0.908 0.091
M25.93 Joint disorder, unspecified (Forearm)
0.000 0.909 0.091
M25.95 Joint disorder, unspecified (Pelvic region and thigh)
0.000 0.910 0.090
M25.06 Haemarthrosis (Lower leg)
0.000 0.913 0.087
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.086 0.914 0.000
M25.09 Haemarthrosis (Site unspecified)
0.000 0.916 0.084
M25.08 Haemarthrosis (Other)
0.000 0.916 0.084
M25.07 Haemarthrosis (Ankle and foot)
0.000 0.916 0.084
M25.05 Haemarthrosis (Pelvic region and thigh)
0.000 0.916 0.084
M25.04 Haemarthrosis (Hand)
0.000 0.916 0.084
M25.03 Haemarthrosis (Forearm)
0.000 0.916 0.084
M25.02 Haemarthrosis (Upper arm)
0.000 0.916 0.084
M25.01 Haemarthrosis (Shoulder region)
0.000 0.916 0.084
M25.00 Haemarthrosis (Multiple sites)
0.000 0.916 0.084
R39.0 Extravasation of urine
0.084 0.916 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.917 0.083
C71.3 Parietal lobe
0.083 0.917 0.000
M25.19 Fistula of joint (Site unspecified)
0.000 0.919 0.081
M25.18 Fistula of joint (Other)
0.000 0.919 0.081
M25.17 Fistula of joint (Ankle and foot)
0.000 0.919 0.081
M25.16 Fistula of joint (Lower leg)
0.000 0.919 0.081
M25.15 Fistula of joint (Pelvic region and thigh)
0.000 0.919 0.081
M25.14 Fistula of joint (Hand)
0.000 0.919 0.081
M25.13 Fistula of joint (Forearm)
0.000 0.919 0.081
M25.12 Fistula of joint (Upper arm)
0.000 0.919 0.081
M25.11 Fistula of joint (Shoulder region)
0.000 0.919 0.081
M25.10 Fistula of joint (Multiple sites)
0.000 0.919 0.081
M25.29 Flail joint (Site unspecified)
0.000 0.919 0.081
M25.28 Flail joint (Other)
0.000 0.919 0.081
M25.27 Flail joint (Ankle and foot)
0.000 0.919 0.081
M25.26 Flail joint (Lower leg)
0.000 0.919 0.081
M25.25 Flail joint (Pelvic region and thigh)
0.000 0.919 0.081
M25.24 Flail joint (Hand)
0.000 0.919 0.081
M25.23 Flail joint (Forearm)
0.000 0.919 0.081
M25.22 Flail joint (Upper arm)
0.000 0.919 0.081
M25.21 Flail joint (Shoulder region)
0.000 0.919 0.081
M25.20 Flail joint (Multiple sites)
0.000 0.919 0.081
M25.97 Joint disorder, unspecified (Ankle and foot)
0.000 0.921 0.079
E66 Obesity
0.000 0.926 0.074
S02.4 Fracture of malar and maxillary bones
0.000 0.927 0.073
C71.7 Brain stem
0.070 0.930 0.000
C71.6 Cerebellum
0.070 0.930 0.000
C71.5 Cerebral ventricle
0.070 0.930 0.000
C71.8 Overlapping lesion of brain
0.070 0.930 0.000
R32 Unspecified urinary incontinence
0.066 0.934 0.000
C71.4 Occipital lobe
0.066 0.934 0.000
K90-K93 Other diseases of the digestive system
0.000 0.935 0.065
I21.4 Acute subendocardial myocardial infarction
0.062 0.938 0.000
S02 Fracture of skull and facial bones
0.000 0.941 0.059
M25.3 Other instability of joint
0.000 0.942 0.058
M45-M49 Spondylopathies
0.058 0.942 0.000
E04.2 Non-toxic multinodular goitre
0.000 0.942 0.058
C71.1 Frontal lobe
0.057 0.943 0.000
S06 Intracranial injury
0.000 0.945 0.055
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.946 0.054
S00-S09 Injuries to the head
0.000 0.946 0.054
E66.1 Drug-induced obesity
0.000 0.947 0.053
S02.41 Fracture of malar and maxillary bones (open)
0.000 0.947 0.052
S02.6 Fracture of mandible
0.000 0.948 0.052
M25.8 Other specified joint disorders
0.000 0.948 0.052
S06.3 Focal brain injury
0.000 0.949 0.051
S06.0 Concussion
0.000 0.950 0.050
S06.30 Focal brain injury (without open intracranial wound)
0.000 0.951 0.049
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.048 0.952 0.000
S06.2 Diffuse brain injury
0.000 0.952 0.048
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.953 0.047
S06.5 Traumatic subdural haemorrhage
0.000 0.953 0.047
N93.8 Other specified abnormal uterine and vaginal bleeding
0.000 0.953 0.047
S02.60 Fracture of mandible (closed)
0.000 0.953 0.047
S00 Superficial injury of head
0.000 0.954 0.046
S06.00 Concussion (without open intracranial wound)
0.000 0.954 0.046
S05 Injury of eye and orbit
0.000 0.954 0.046
E04.9 Non-toxic goitre, unspecified
0.000 0.954 0.046
S02.9 Fracture of skull and facial bones, part unspecified
0.000 0.955 0.045
S00.1 Contusion of eyelid and periocular area
0.000 0.955 0.045
E04.1 Non-toxic single thyroid nodule
0.000 0.957 0.043
S06.20 Diffuse brain injury (without open intracranial wound)
0.000 0.957 0.042
S09 Other and unspecified injuries of head
0.000 0.957 0.043
S09.8 Other specified injuries of head
0.000 0.958 0.042
M25.31 Other instability of joint (Shoulder region)
0.000 0.958 0.042
M25.39 Other instability of joint (Site unspecified)
0.000 0.958 0.042
M25.38 Other instability of joint (Other)
0.000 0.958 0.042
M25.35 Other instability of joint (Pelvic region and thigh)
0.000 0.958 0.042
M25.32 Other instability of joint (Upper arm)
0.000 0.958 0.042
M25.30 Other instability of joint (Multiple sites)
0.000 0.958 0.042
S06.50 Traumatic subdural haemorrhage (without open intracranial wound)
0.000 0.959 0.041
S02.3 Fracture of orbital floor
0.000 0.959 0.041

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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