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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6930616
log Bayes Factor = 48.5109
Chromosome 6   position 26,331,969  (GRCh37) Explore rs6930616 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.006 0.994
E10-E14 Diabetes mellitus
0.000 0.010 0.990
E10 Insulin-dependent diabetes mellitus
0.000 0.018 0.982
E11.2 With renal complications
0.000 0.022 0.978
E11.5 With peripheral circulatory complications
0.000 0.060 0.940
E11.9 Without complications
0.000 0.070 0.930
E11.3 With ophthalmic complications
0.000 0.085 0.915
E10.0 With coma
0.000 0.087 0.913
I10 Essential (primary) hypertension
0.000 0.088 0.912
E10.5 With peripheral circulatory complications
0.000 0.099 0.901
E11.4 With neurological complications
0.000 0.113 0.887
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.123 0.877
E10.3 With ophthalmic complications
0.000 0.125 0.875
E83 Disorders of mineral metabolism
0.000 0.128 0.872
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.138 0.862
E16 Other disorders of pancreatic internal secretion
0.000 0.148 0.852
E10.1 With ketoacidosis
0.000 0.148 0.851
E70-E90 Metabolic disorders
0.000 0.151 0.849
E16.2 Hypoglycaemia, unspecified
0.000 0.155 0.845
E11.6 With other specified complications
0.000 0.176 0.824
E14 Unspecified diabetes mellitus
0.000 0.204 0.796
E40-E46 Malnutrition
0.000 0.211 0.789
E11.1 With ketoacidosis
0.000 0.248 0.752
E11.0 With coma
0.000 0.258 0.742
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.269 0.731
E46 Unspecified protein-energy malnutrition
0.000 0.274 0.726
E14.3 With ophthalmic complications
0.000 0.274 0.726
E10.7 With multiple complications
0.000 0.280 0.719
E10.8 With unspecified complications
0.000 0.281 0.719
E10.2 With renal complications
0.000 0.287 0.713
E11.7 With multiple complications
0.000 0.287 0.713
E12 Malnutrition-related diabetes mellitus
0.000 0.290 0.710
E88 Other metabolic disorders
0.000 0.302 0.698
E10.4 With neurological complications
0.000 0.321 0.679
E73 Lactose intolerance
0.000 0.336 0.664
E84 Cystic fibrosis
0.000 0.338 0.662
E14.6 With other specified complications
0.000 0.345 0.654
E13 Other specified diabetes mellitus
0.000 0.346 0.654
E80.4 Gilbert's syndrome
0.000 0.350 0.650
E14.5 With peripheral circulatory complications
0.000 0.371 0.629
E79 Disorders of purine and pyrimidine metabolism
0.000 0.372 0.628
E10.9 Without complications
0.000 0.372 0.628
E10.6 With other specified complications
0.000 0.373 0.627
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.375 0.625
E83.8 Other disorders of mineral metabolism
0.000 0.375 0.625
E83.2 Disorders of zinc metabolism
0.000 0.375 0.625
E83.0 Disorders of copper metabolism
0.000 0.375 0.625
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.378 0.622
E15 Nondiabetic hypoglycaemic coma
0.000 0.382 0.618
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.386 0.614
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.389 0.611
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.389 0.611
E16.4 Abnormal secretion of gastrin
0.000 0.389 0.611
E16.3 Increased secretion of glucagon
0.000 0.389 0.611
E76 Disorders of glycosaminoglycan metabolism
0.000 0.391 0.609
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.391 0.609
E70 Disorders of aromatic amino-acid metabolism
0.000 0.391 0.609
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.391 0.609
E16.1 Other hypoglycaemia
0.000 0.405 0.595
E14.1 With ketoacidosis
0.000 0.419 0.581
E77 Disorders of glycoprotein metabolism
0.000 0.421 0.579
E14.8 With unspecified complications
0.000 0.425 0.575
E88.8 Other specified metabolic disorders
0.000 0.426 0.574
E14.7 With multiple complications
0.000 0.429 0.571
E14.0 With coma
0.000 0.429 0.571
E83.3 Disorders of phosphorus metabolism
0.000 0.433 0.567
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.434 0.566
E45 Retarded development following protein-energy malnutrition
0.000 0.434 0.566
E43 Unspecified severe protein-energy malnutrition
0.000 0.434 0.566
E42 Marasmic kwashiorkor
0.000 0.434 0.566
E41 Nutritional marasmus
0.000 0.434 0.566
E40 Kwashiorkor
0.000 0.434 0.566
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.444 0.556
E80.2 Other porphyria
0.000 0.448 0.552
E72 Other disorders of amino-acid metabolism
0.000 0.454 0.546
E14.4 With neurological complications
0.000 0.463 0.537
E73.9 Lactose intolerance, unspecified
0.000 0.469 0.531
E84.9 Cystic fibrosis, unspecified
0.000 0.472 0.528
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.476 0.524
E80.5 Crigler-Najjar syndrome
0.000 0.476 0.524
E80.3 Defects of catalase and peroxydase
0.000 0.476 0.524
E80.1 Porphyria cutanea tarda
0.000 0.476 0.524
E80.0 Hereditary erythropoietic porphyria
0.000 0.476 0.524
E74 Other disorders of carbohydrate metabolism
0.000 0.484 0.516
E12.9 Without complications
0.000 0.491 0.509
E12.8 With unspecified complications
0.000 0.491 0.509
E12.7 With multiple complications
0.000 0.491 0.509
E12.6 With other specified complications
0.000 0.491 0.509
E12.5 With peripheral circulatory complications
0.000 0.491 0.509
E12.4 With neurological complications
0.000 0.491 0.509
E12.3 With ophthalmic complications
0.000 0.491 0.509
E12.2 With renal complications
0.000 0.491 0.509
E12.1 With ketoacidosis
0.000 0.491 0.509
E12.0 With coma
0.000 0.491 0.509
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.492 0.508
E88.3 Tumour lysis syndrome
0.000 0.499 0.501
E88.9 Metabolic disorder, unspecified
0.000 0.506 0.494
E80.6 Other disorders of bilirubin metabolism
0.000 0.516 0.483
E65-E68 Obesity and other hyperalimentation
0.000 0.520 0.480
E73.8 Other lactose intolerance
0.000 0.524 0.476
E73.1 Secondary lactase deficiency
0.000 0.524 0.476
E73.0 Congenital lactase deficiency
0.000 0.524 0.476
E84.8 Cystic fibrosis with other manifestations
0.000 0.525 0.475
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.525 0.475
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.525 0.475
E13.3 With ophthalmic complications
0.000 0.525 0.475
E83.4 Disorders of magnesium metabolism
0.000 0.526 0.474
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.530 0.470
E13.8 With unspecified complications
0.000 0.531 0.469
E13.7 With multiple complications
0.000 0.531 0.469
E13.6 With other specified complications
0.000 0.531 0.469
E13.5 With peripheral circulatory complications
0.000 0.531 0.469
E13.4 With neurological complications
0.000 0.531 0.469
E13.2 With renal complications
0.000 0.531 0.469
E13.1 With ketoacidosis
0.000 0.531 0.469
E13.0 With coma
0.000 0.531 0.469
E11.8 With unspecified complications
0.000 0.533 0.466
E14.2 Withrenal complications
0.000 0.541 0.459
E88.2 Lipomatosis, not elsewhere classified
0.000 0.542 0.458
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.549 0.450
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.549 0.450
E79.1 Lesch-Nyhan syndrome
0.000 0.549 0.450
E75.5 Other lipid storage disorders
0.000 0.555 0.445
E75.6 Lipid storage disorder, unspecified
0.000 0.560 0.440
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.560 0.440
E75.3 Sphingolipidosis, unspecified
0.000 0.560 0.440
E75.2 Other sphingolipidosis
0.000 0.560 0.440
E75.1 Other gangliosidosis
0.000 0.560 0.440
E75.0 GM2 gangliosidosis
0.000 0.560 0.440
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.563 0.437
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.563 0.437
E70.3 Albinism
0.000 0.563 0.437
E70.2 Disorders of tyrosine metabolism
0.000 0.563 0.437
E70.1 Other hyperphenylalaninaemias
0.000 0.563 0.437
E70.0 Classical phenylketonuria
0.000 0.563 0.437
E71.3 Disorders of fatty-acid metabolism
0.000 0.563 0.437
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.563 0.437
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.563 0.437
E71.0 Maple-syrup-urine disease
0.000 0.563 0.437
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.563 0.437
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.563 0.437
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.563 0.437
E76.2 Other mucopolysaccharidoses
0.000 0.563 0.437
E76.1 Mucopolysaccharidosis, type II
0.000 0.563 0.437
E76.0 Mucopolysaccharidosis, type I
0.000 0.563 0.437
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.585 0.415
E77.1 Defects in glycoprotein degradation
0.000 0.585 0.415
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.585 0.415
E44.1 Mild protein-energy malnutrition
0.000 0.594 0.406
E44.0 Moderate protein-energy malnutrition
0.000 0.594 0.406
E13.9 Without complications
0.000 0.594 0.405
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.608 0.391
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.608 0.391
E72.5 Disorders of glycine metabolism
0.000 0.608 0.391
E72.4 Disorders of ornithine metabolism
0.000 0.608 0.391
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.608 0.391
E72.2 Disorders of urea cycle metabolism
0.000 0.608 0.391
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.608 0.391
E65 Localised adiposity
0.000 0.615 0.385
E77.8 Other disorders of glycoprotein metabolism
0.000 0.615 0.385
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.630 0.370
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.630 0.370
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.630 0.370
E74.2 Disorders of galactose metabolism
0.000 0.630 0.370
E74.1 Disorders of fructose metabolism
0.000 0.630 0.370
E83.5 Disorders of calcium metabolism
0.000 0.636 0.364
E74.0 Glycogen storage disease
0.000 0.643 0.357
E67 Other hyperalimentation
0.000 0.656 0.344
E68 Sequelae of hyperalimentation
0.000 0.656 0.344
E72.0 Disorders of amino-acid transport
0.000 0.671 0.328
E85 Amyloidosis
0.001 0.689 0.310
K90 Intestinal malabsorption
0.000 0.699 0.301
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.703 0.297
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.748 0.252
E67.8 Other specified hyperalimentation
0.000 0.753 0.247
E67.3 Hypervitaminosis D
0.000 0.753 0.247
E67.2 Megavitamin-B6 syndrome
0.000 0.753 0.247
E67.1 Hypercarotenaemia
0.000 0.753 0.247
E67.0 Hypervitaminosis A
0.000 0.753 0.247
E85.8 Other amyloidosis
0.001 0.770 0.230
E50-E64 Other nutritional deficiencies
0.001 0.777 0.223
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.777 0.222
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.777 0.222
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.777 0.222
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.781 0.219
K90.3 Pancreatic steatorrhoea
0.000 0.784 0.216
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.784 0.216
K90.1 Tropical sprue
0.000 0.784 0.216
E89.4 Postprocedural ovarian failure
0.000 0.785 0.215
E14.9 Without complications
0.000 0.799 0.201
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.808 0.192
I10-I15 Hypertensive diseases
0.000 0.814 0.186
K90.8 Other intestinal malabsorption
0.000 0.815 0.185
K90.9 Intestinal malabsorption, unspecified
0.000 0.816 0.183
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.819 0.181
E89.1 Postprocedural hypoinsulinaemia
0.000 0.819 0.181
E85.4 Organ-limited amyloidosis
0.001 0.821 0.178
E56 Other vitamin deficiencies
0.000 0.831 0.169
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.000 0.833 0.167
E00-E07 Disorders of thyroid gland
0.000 0.834 0.166
E89.5 Postprocedural testicular hypofunction
0.000 0.835 0.164
E64 Sequelae of malnutrition and other nutritional deficiencies
0.001 0.840 0.160
E63 Other nutritional deficiencies
0.001 0.840 0.160
E50 Vitamin A deficiency
0.001 0.840 0.160
E60 Dietary zinc deficiency
0.001 0.840 0.160
E59 Dietary selenium deficiency
0.001 0.840 0.160
E54 Ascorbic acid deficiency
0.001 0.840 0.160
E52 Niacin deficiency [pellagra]
0.001 0.840 0.160
E85.9 Amyloidosis, unspecified
0.001 0.841 0.158
E58 Dietary calcium deficiency
0.001 0.844 0.156
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.845 0.154
E51 Thiamine deficiency
0.001 0.848 0.151
E85.3 Secondary systemic amyloidosis
0.001 0.850 0.149
I11 Hypertensive heart disease
0.000 0.857 0.143
I13 Hypertensive heart and renal disease
0.000 0.866 0.134
E03 Other hypothyroidism
0.000 0.866 0.134
E89.2 Postprocedural hypoparathyroidism
0.000 0.869 0.130
E56.1 Deficiency of vitamin K
0.000 0.870 0.130
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.871 0.129
E89.3 Postprocedural hypopituitarism
0.000 0.877 0.123
E56.9 Vitamin deficiency, unspecified
0.000 0.878 0.121
E56.8 Deficiency of other vitamins
0.000 0.878 0.121
E56.0 Deficiency of vitamin E
0.000 0.878 0.121
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.880 0.120
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.881 0.119
E00 Congenital iodine-deficiency syndrome
0.000 0.881 0.119
E50.9 Vitamin A deficiency, unspecified
0.001 0.885 0.115
E50.8 Other manifestations of vitamin A deficiency
0.001 0.885 0.115
E50.7 Other ocular manifestations of vitamin A deficiency
0.001 0.885 0.115
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.001 0.885 0.115
E50.5 Vitamin A deficiency with night blindness
0.001 0.885 0.115
E50.4 Vitamin A deficiency with keratomalacia
0.001 0.885 0.115
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.001 0.885 0.115
E50.2 Vitamin A deficiency with corneal xerosis
0.001 0.885 0.115
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.001 0.885 0.115
E50.0 Vitamin A deficiency with conjunctival xerosis
0.001 0.885 0.115
E63.9 Nutritional deficiency, unspecified
0.001 0.885 0.115
E63.8 Other specified nutritional deficiencies
0.001 0.885 0.115
E63.1 Imbalance of constituents of food intake
0.001 0.885 0.115
E63.0 Essential fatty acid [EFA] deficiency
0.001 0.885 0.115
E64.9 Sequelae of unspecified nutritional deficiency
0.001 0.885 0.115
E64.8 Sequelae of other nutritional deficiencies
0.001 0.885 0.115
E64.3 Sequelae of rickets
0.001 0.885 0.115
E64.2 Sequelae of vitamin C deficiency
0.001 0.885 0.115
E64.1 Sequelae of vitamin A deficiency
0.001 0.885 0.115
E64.0 Sequelae of protein-energy malnutrition
0.001 0.885 0.115
E86 Volume depletion
0.000 0.886 0.114
I15 Secondary hypertension
0.000 0.888 0.112
E51.9 Thiamine deficiency, unspecified
0.001 0.891 0.108
E51.8 Other manifestations of thiamine deficiency
0.001 0.891 0.108
E51.1 Beriberi
0.001 0.891 0.108
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.894 0.106
E53 Deficiency of other B group vitamins
0.000 0.896 0.104
E61 Deficiency of other nutrient elements
0.001 0.897 0.102
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.898 0.102
E51.2 Wernicke's encephalopathy
0.001 0.900 0.099
E55 Vitamin D deficiency
0.001 0.901 0.098
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.903 0.097
E03.8 Other specified hypothyroidism
0.000 0.904 0.096
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.904 0.096
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.904 0.096
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.904 0.096
E03.5 Myxoedema coma
0.000 0.904 0.096
E03.4 Atrophy of thyroid (acquired)
0.000 0.904 0.096
E03.3 Postinfectious hypothyroidism
0.000 0.904 0.096
E03.1 Congenital hypothyroidism without goitre
0.000 0.904 0.096
E06 Thyroiditis
0.000 0.904 0.096
E20-E35 Disorders of other endocrine glands
0.000 0.905 0.095
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.910 0.090
E05.9 Thyrotoxicosis, unspecified
0.000 0.914 0.086
I15.9 Seconday hypertension, unspecified
0.000 0.914 0.085
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.914 0.085
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.914 0.085
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.914 0.085
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.914 0.085
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.914 0.085
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.914 0.085
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.914 0.085
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.914 0.085
E03.9 Hypothyroidism, unspecified
0.000 0.919 0.081
E05.8 Other thyrotoxicosis
0.000 0.919 0.081
I15.8 Other secondary hypertension
0.000 0.919 0.080
I15.2 Hypertension secondary to endocrine disorders
0.000 0.921 0.079
E20 Hypoparathyroidism
0.000 0.924 0.076
I15.0 Renovascular hypertension
0.000 0.924 0.076
E06.3 Autoimmune thyroiditis
0.000 0.924 0.076
E29 Testicular dysfunction
0.000 0.924 0.075
E53.1 Pyridoxine deficiency
0.000 0.925 0.075
E53.0 Riboflavin deficiency
0.000 0.925 0.075
E61.9 Deficiency of nutrient element, unspecified
0.001 0.926 0.074
E61.8 Deficiency of other specified nutrient elements
0.001 0.926 0.074
E61.7 Deficiency of multiple nutrient elements
0.001 0.926 0.074
E61.6 Vanadium deficiency
0.001 0.926 0.074
E61.5 Molybdenum deficiency
0.001 0.926 0.074
E61.4 Chromium deficiency
0.001 0.926 0.074
E61.3 Manganese deficiency
0.001 0.926 0.074
E61.0 Copper deficiency
0.001 0.926 0.074
E05.5 Thyroid crisis or storm
0.000 0.926 0.074
E05.4 Thyrotoxicosis factitia
0.000 0.926 0.074
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.926 0.074
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.926 0.074
E07 Other disorders of thyroid
0.000 0.926 0.073
E55.0 Rickets, active
0.001 0.929 0.070
E66 Obesity
0.000 0.929 0.071
E25 Adrenogenital disorders
0.000 0.929 0.071
E06.4 Drug-induced thyroiditis
0.000 0.931 0.069
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.931 0.069
E06.0 Acute thyroiditis
0.000 0.931 0.069
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.932 0.068
E32 Diseases of thymus
0.000 0.932 0.068
E31 Polyglandular dysfunction
0.000 0.932 0.068
E30 Disorders of puberty, not elsewhere classified
0.000 0.932 0.068
E26 Hyperaldosteronism
0.000 0.934 0.066
E61.2 Magnesium deficiency
0.001 0.934 0.066
E06.9 Thyroiditis, unspecified
0.000 0.934 0.066
E89.0 Postprocedural hypothyroidism
0.000 0.935 0.065
E20.9 Hypoparathyroidism, unspecified
0.000 0.937 0.063
E53.9 Vitamin B deficiency, unspecified
0.000 0.937 0.063
E34 Other endocrine disorders
0.000 0.937 0.063
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.938 0.062
E29.1 Testicular hypofunction
0.000 0.938 0.062
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.938 0.062
E06.5 Other chronic thyroiditis
0.000 0.940 0.060
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.940 0.060
I15.1 Hypertension secondary to other renal disorders
0.000 0.941 0.059
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.942 0.058
I83 Varicose veins of lower extremities
0.000 0.944 0.056
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.944 0.056
E20.8 Other hypoparathyroidism
0.000 0.945 0.055
E20.1 Pseudohypoparathyroidism
0.000 0.945 0.055
E20.0 Idiopathic hypoparathyroidism
0.000 0.945 0.055
I12 Hypertensive renal disease
0.000 0.945 0.054
E29.9 Testicular dysfunction, unspecified
0.000 0.946 0.054
E29.8 Other testicular dysfunction
0.000 0.946 0.054
E29.0 Testicular hyperfunction
0.000 0.946 0.054
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.946 0.054
E07.1 Dyshormogenetic goitre
0.000 0.947 0.053
E07.0 Hypersecretion of calcitonin
0.000 0.947 0.053
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.947 0.052
E27 Other disorders of adrenal gland
0.000 0.948 0.052
E66.1 Drug-induced obesity
0.000 0.949 0.051
E34.9 Endocrine disorder, unspecified
0.000 0.949 0.051
E06.1 Subacute thyroiditis
0.000 0.949 0.051
E25.9 Adrenogenital disorder, unspecified
0.000 0.949 0.051
E25.8 Other adrenogenital disorders
0.000 0.949 0.051
E26.9 Hyperaldosteronism, unspecified
0.000 0.950 0.050
E78.1 Pure hyperglyceridaemia
0.000 0.950 0.050
E30.9 Disorder of puberty, unspecified
0.000 0.951 0.049
E30.8 Other disorders of puberty
0.000 0.951 0.049
E30.1 Precocious puberty
0.000 0.951 0.049
E30.0 Delayed puberty
0.000 0.951 0.049
E31.9 Polyglandular dysfunction, unspecified
0.000 0.951 0.049
E31.8 Other polyglandular dysfunction
0.000 0.951 0.049
E31.1 Polyglandular hyperfunction
0.000 0.951 0.049
E31.0 Autoimmune polyglandular failure
0.000 0.951 0.049
E32.9 Disease of thymus, unspecified
0.000 0.951 0.049
E32.8 Other diseases of thymus
0.000 0.951 0.049
E32.1 Abscess of thymus
0.000 0.951 0.049
E32.0 Persistent hyperplasia of thymus
0.000 0.951 0.049
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.951 0.049
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.951 0.049
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.951 0.049
E78.4 Other hyperlipidaemia
0.000 0.951 0.049
R40.0 Somnolence
0.048 0.952 0.000
E21.2 Other hyperparathyroidism
0.000 0.952 0.048
E26.8 Other hyperaldosteronism
0.000 0.952 0.048
E26.1 Secondary hyperaldosteronism
0.000 0.952 0.048
E07.8 Other specified disorders of thyroid
0.000 0.953 0.047
E34.8 Other specified endocrine disorders
0.000 0.954 0.046
E78.6 Lipoprotein deficiency
0.000 0.954 0.046
E34.5 Androgen resistance syndrome
0.000 0.954 0.045
E34.4 Constitutional tall stature
0.000 0.954 0.045
E34.3 Short stature, not elsewhere classified
0.000 0.954 0.045
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.954 0.045
E34.1 Other hypersecretion of intestinal hormones
0.000 0.954 0.045
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.955 0.045
E28 Ovarian dysfunction
0.000 0.955 0.045
I83.0 Varicose veins of lower extremities with ulcer
0.000 0.955 0.045
E21.4 Other specified disorders of parathyroid gland
0.000 0.956 0.044
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.956 0.044
E78.3 Hyperchylomicronaemia
0.000 0.957 0.043
E26.0 Primary hyperaldosteronism
0.000 0.957 0.043
E53.8 Deficiency of other specified B group vitamins
0.000 0.957 0.042
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.960 0.040
E27.1 Primary adrenocortical insufficiency
0.000 0.960 0.040
E22 Hyperfunction of pituitary gland
0.000 0.961 0.039
E24 Cushing's syndrome
0.000 0.962 0.038
I83.1 Varicose veins of lower extremities with inflammation
0.000 0.962 0.038
E27.5 Adrenomedullary hyperfunction
0.000 0.962 0.037
E27.0 Other adrenocortical overactivity
0.000 0.962 0.037
E87.5 Hyperkalaemia
0.000 0.964 0.036
E27.2 Addisonian crisis
0.000 0.964 0.036
E21.0 Primary hyperparathyroidism
0.000 0.964 0.036
E61.1 Iron deficiency
0.001 0.965 0.034
E27.9 Disorder of adrenal gland, unspecified
0.000 0.967 0.033
E23 Hypofunction and other disorders of pituitary gland
0.000 0.967 0.033
E28.9 Ovarian dysfunction, unspecified
0.000 0.967 0.032
E28.8 Other ovarian dysfunction
0.000 0.967 0.032
E28.1 Androgen excess
0.000 0.967 0.032
E28.0 Oestrogen excess
0.000 0.967 0.032
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.967 0.032
E78.8 Other disorders of lipoprotein metabolism
0.000 0.968 0.032
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.968 0.032
E27.8 Other specified disorders of adrenal gland
0.000 0.968 0.031
E66.0 Obesity due to excess calories
0.000 0.969 0.031
E78.2 Mixed hyperlipidaemia
0.000 0.969 0.030
D45 Polycythaemia vera
0.000 0.970 0.030
E28.3 Primary ovarian failure
0.000 0.970 0.030
E87.3 Alkalosis
0.000 0.970 0.030
E22.1 Hyperprolactinaemia
0.000 0.970 0.029
E87.4 Mixed disorder of acid-base balance
0.000 0.971 0.029
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.000 0.971 0.029
E34.0 Carcinoid syndrome
0.000 0.971 0.028
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.971 0.028
E22.8 Other hyperfunction of pituitary gland
0.000 0.971 0.028
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.972 0.027
E24.3 Ectopic ACTH syndrome
0.000 0.972 0.027
E24.1 Nelson's syndrome
0.000 0.972 0.027
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.972 0.028
E24.2 Drug-induced Cushing's syndrome
0.000 0.972 0.027
K90-K93 Other diseases of the digestive system
0.000 0.973 0.027
I12.9 Hypertensive renal disease without renal failure
0.000 0.974 0.026
E87.0 Hyperosmolality and hypernatraemia
0.000 0.974 0.026
E22.0 Acromegaly and pituitary gigantism
0.000 0.976 0.024
E24.0 Pituitary-dependent Cushing's disease
0.000 0.976 0.023
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.976 0.023
E23.1 Drug-induced hypopituitarism
0.000 0.976 0.023
E24.8 Other Cushing's syndrome
0.001 0.976 0.023
E23.7 Disorder of pituitary gland, unspecified
0.000 0.978 0.022
E07.9 Disorder of thyroid, unspecified
0.000 0.978 0.022
L40.5 Arthropathic psoriasis
0.022 0.978 0.000
E23.2 Diabetes insipidus
0.000 0.978 0.022
E21.3 Hyperparathyroidism, unspecified
0.000 0.979 0.021
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.980 0.020
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.981 0.019
E23.6 Other disorders of pituitary gland
0.000 0.981 0.019
E24.9 Cushing's syndrome, unspecified
0.000 0.982 0.018
D37-D48 Neoplasms of uncertain or unknown behaviour
0.000 0.982 0.018
D46 Myelodysplastic syndromes
0.000 0.983 0.017
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.000 0.983 0.017
D39.1 Ovary
0.000 0.984 0.016
E04 Other non-toxic goitre
0.000 0.984 0.016
L40 Psoriasis
0.016 0.984 0.000
L40.0 Psoriasis vulgaris
0.016 0.984 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.000 0.984 0.016
E28.2 Polycystic ovarian syndrome
0.000 0.985 0.015
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.000 0.985 0.015
D46.9 Myelodysplastic syndrome, unspecified
0.000 0.985 0.015
D46.4 Refractory anaemia, unspecified
0.000 0.985 0.015
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.986 0.014
K93.1 Megacolon in Chagas' disease
0.000 0.986 0.014
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.986 0.014
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.986 0.014
D37.7 Other digestive organs
0.000 0.986 0.014
E66.8 Other obesity
0.000 0.986 0.014
D37.3 Appendix
0.000 0.987 0.013
D46.7 Other myelodysplastic syndromes
0.000 0.987 0.013
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.000 0.987 0.013
D44.3 Pituitary gland
0.000 0.987 0.013
D46.1 Refractory anaemia with sideroblasts
0.000 0.987 0.013
D37.6 Liver, gallbladder and bile ducts
0.000 0.987 0.013
D39.7 Other female genital organs
0.000 0.987 0.013
D46.2 Refractory anaemia with excess of blasts
0.000 0.987 0.013
D47.3 Essential (haemorrhagic) thrombocythaemia
0.000 0.987 0.013
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.987 0.013
D46.6 Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
0.000 0.988 0.012
D46.5 Refractory anaemia with multi-lineage dysplasia
0.000 0.988 0.012
D46.3 Refractory anaemia with excess of blasts with transformation
0.000 0.988 0.012
D46.0 Refractory anaemia without sideroblasts, so stated
0.000 0.988 0.012
D39.0 Uterus
0.000 0.988 0.012
D39.9 Female genital organ, unspecified
0.000 0.988 0.012
D39.2 Placenta
0.000 0.988 0.012
D37.4 Colon
0.000 0.988 0.012
D37.1 Stomach
0.000 0.988 0.012
L40.4 Guttate psoriasis
0.012 0.988 0.000
L40.9 Psoriasis, unspecified
0.012 0.988 0.000
D44.7 Aortic body and other paraganglia
0.000 0.988 0.012
D37.9 Digestive organ, unspecified
0.000 0.988 0.012
E04.8 Other specified non-toxic goitre
0.000 0.988 0.012
L40.2 Acrodermatitis continua
0.012 0.988 0.000
D44.0 Thyroid gland
0.000 0.988 0.012
D86.9 Sarcoidosis, unspecified
0.000 0.988 0.012
M07.39 Other psoriatic arthropathies (Site unspecified)
0.011 0.989 0.000
D44.6 Carotid body
0.000 0.989 0.011
D47.2 Monoclonal gammopathy
0.000 0.989 0.011
L40.3 Pustulosis palmaris et plantaris
0.011 0.989 0.000
L40.1 Generalised pustular psoriasis
0.011 0.989 0.000
D44.5 Pineal gland
0.000 0.989 0.011
D44.2 Parathyroid gland
0.000 0.989 0.011
D86 Sarcoidosis
0.000 0.989 0.011
E55.9 Vitamin D deficiency, unspecified
0.002 0.989 0.009
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.989 0.011
D75.1 Secondary polycythaemia
0.000 0.990 0.010
D44.9 Endocrine gland, unspecified
0.000 0.990 0.010
D86.0 Sarcoidosis of lung
0.000 0.990 0.010
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]
0.000 0.990 0.010
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour
0.000 0.990 0.010
L40.8 Other psoriasis
0.010 0.990 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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