TreeWAS – Variant ID: rs7121538

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I42.0 Dilated cardiomyopathy	0.028	0.972	0.000
I31.3 Pericardial effusion (noninflammatory)	0.000	0.978	0.022
I42 Cardiomyopathy	0.018	0.982	0.000
I42.1 Obstructive hypertrophic cardiomyopathy	0.017	0.983	0.000
I42.7 Cardiomyopathy due to drugs and other external agents	0.014	0.986	0.000
I42.5 Other restrictive cardiomyopathy	0.013	0.987	0.000
I42.4 Endocardial fibroelastosis	0.013	0.987	0.000
I42.3 Endomyocardial (eosinophilic) disease	0.013	0.987	0.000
I42.2 Other hypertrophic cardiomyopathy	0.013	0.987	0.000
I42.9 Cardiomyopathy, unspecified	0.013	0.987	0.000
I42.6 Alcoholic cardiomyopathy	0.012	0.988	0.000
I31 Other diseases of pericardium	0.000	0.988	0.012
I31.9 Disease of pericardium, unspecified	0.000	0.989	0.011
I42.8 Other cardiomyopathies	0.011	0.989	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.011	0.989	0.000
O26.8 Other specified pregnancy-related conditions	0.011	0.989	0.000
K72.9 Hepatic failure, unspecified	0.010	0.990	0.000
I31.8 Other specified diseases of pericardium	0.000	0.991	0.009
I31.2 Haemopericardium, not elsewhere classified	0.000	0.991	0.009
M79.62 Pain in limb (Upper arm)	0.000	0.991	0.009
I31.0 Chronic adhesive pericarditis	0.000	0.992	0.008
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.000	0.992	0.008
I31.1 Chronic constrictive pericarditis	0.000	0.992	0.008
M81.9 Osteoporosis, unspecified	0.008	0.992	0.000
O26 Maternal care for other conditions predominantly related to pregnancy	0.008	0.992	0.000
K92.2 Gastro-intestinal haemorrhage, unspecified	0.000	0.992	0.008
O26.9 Pregnancy-related condition, unspecified	0.007	0.993	0.000
M81.94 Osteoporosis, unspecified (Hand)	0.007	0.993	0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.006	0.993	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.000	0.993	0.007
H18.5 Hereditary corneal dystrophies	0.006	0.993	0.000
M81.93 Osteoporosis, unspecified (Forearm)	0.006	0.994	0.000
K72 Hepatic failure, not elsewhere classified	0.006	0.994	0.000
O26.6 Liver disorders in pregnancy, childbirth and the puerperium	0.006	0.994	0.000
M81.92 Osteoporosis, unspecified (Upper arm)	0.006	0.994	0.000
M81.91 Osteoporosis, unspecified (Shoulder region)	0.006	0.994	0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.006	0.994	0.000
O26.5 Maternal hypotension syndrome	0.006	0.994	0.000
O26.4 Herpes gestationis	0.006	0.994	0.000
O26.3 Retained intra-uterine contraceptive device in pregnancy	0.006	0.994	0.000
O26.1 Low weight gain in pregnancy	0.006	0.994	0.000
O26.0 Excessive weight gain in pregnancy	0.006	0.994	0.000
M81 Osteoporosis without pathological fracture	0.006	0.994	0.000
K72.0 Acute and subacute hepatic failure	0.006	0.994	0.000
O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium	0.005	0.994	0.000
M81.96 Osteoporosis, unspecified (Lower leg)	0.005	0.994	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.000	0.994	0.006
M81.4 Drug-induced osteoporosis	0.005	0.995	0.000
T39.0 Salicylates	0.000	0.995	0.005
N97.9 Female infertility, unspecified	0.005	0.995	0.000
O26.2 Pregnancy care of habitual aborter	0.005	0.995	0.000
S92.00 Fracture of calcaneus (closed)	0.005	0.995	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.000	0.995	0.005
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.000	0.995	0.005
T47.1 Other antacids and anti-gastric-secretion drugs	0.000	0.995	0.005
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.000	0.995	0.005
M81.40 Drug-induced osteoporosis (Multiple sites)	0.005	0.995	0.000
T39.4 Antirheumatics, not elsewhere classified	0.000	0.995	0.005
T39.2 Pyrazolone derivatives	0.000	0.995	0.005
K72.1 Chronic hepatic failure	0.005	0.995	0.000
M81.99 Osteoporosis, unspecified (Site unspecified)	0.005	0.995	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.995	0.005
M81.98 Osteoporosis, unspecified (Other)	0.005	0.995	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.000	0.995	0.005
M81.49 Drug-induced osteoporosis (Site unspecified)	0.005	0.995	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.000	0.995	0.005
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.000	0.995	0.005
S92.0 Fracture of calcaneus	0.005	0.995	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.000	0.995	0.005
T45.1 Antineoplastic and immunosuppressive drugs	0.000	0.995	0.004
T36 Poisoning by systemic antibiotics	0.000	0.995	0.004
M81.8 Other osteoporosis	0.004	0.996	0.000
M81.6 Localised osteoporosis [Lequesne]	0.004	0.996	0.000
M81.5 Idiopathic osteoporosis	0.004	0.996	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.004	0.996	0.000
M81.1 Postoophorectomy osteoporosis	0.004	0.996	0.000
M81.0 Postmenopausal osteoporosis	0.004	0.996	0.000
J06.9 Acute upper respiratory infection, unspecified	0.000	0.996	0.004
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.000	0.996	0.004
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.000	0.996	0.004
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.000	0.996	0.004
T41 Poisoning by anaesthetics and therapeutic gases	0.000	0.996	0.004
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.000	0.996	0.004
T46 Poisoning by agents primarily affecting the cardiovascular system	0.000	0.996	0.004
M81.48 Drug-induced osteoporosis (Other)	0.004	0.996	0.000
M81.47 Drug-induced osteoporosis (Ankle and foot)	0.004	0.996	0.000
M81.46 Drug-induced osteoporosis (Lower leg)	0.004	0.996	0.000
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)	0.004	0.996	0.000
M81.44 Drug-induced osteoporosis (Hand)	0.004	0.996	0.000
M81.43 Drug-induced osteoporosis (Forearm)	0.004	0.996	0.000
M81.42 Drug-induced osteoporosis (Upper arm)	0.004	0.996	0.000
M81.41 Drug-induced osteoporosis (Shoulder region)	0.004	0.996	0.000
T45.5 Anticoagulants	0.000	0.996	0.004
S92 Fracture of foot, except ankle	0.004	0.996	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.000	0.996	0.004
T45.0 Antiallergic and antiemetic drugs	0.000	0.996	0.004
T42.4 Benzodiazepines	0.000	0.996	0.004
D43.2 Brain, unspecified	0.004	0.996	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.000	0.996	0.004
T47.8 Other agents primarily affecting the gastro-intestinal system	0.000	0.996	0.004
T47.7 Emetics	0.000	0.996	0.004
T47.6 Antidiarrhoeal drugs	0.000	0.996	0.004
T47.5 Digestants	0.000	0.996	0.004
T47.4 Other laxatives	0.000	0.996	0.004
T47.3 Saline and osmotic laxatives	0.000	0.996	0.004
T47.2 Stimulant laxatives	0.000	0.996	0.004
T47.0 Histamine H(2)-receptor antagonists	0.000	0.996	0.004
T45.9 Primarily systemic and haematological agent, unspecified	0.000	0.996	0.004
T45.8 Other primarily systemic and haematological agents	0.000	0.996	0.004
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.000	0.996	0.004
T45.6 Fibrinolysis-affecting drugs	0.000	0.996	0.004
T45.4 Iron and its compounds	0.000	0.996	0.004
T45.3 Enzymes, not elsewhere classified	0.000	0.996	0.004
T45.2 Vitamins, not elsewhere classified	0.000	0.996	0.004
T39.1 4-Aminophenol derivatives	0.000	0.996	0.004
M81.2 Osteoporosis of disuse	0.004	0.996	0.000
T50.8 Diagnostic agents	0.000	0.996	0.004
T50.7 Analeptics and opioid receptor antagonists	0.000	0.996	0.004
T50.6 Antidotes and chelating agents, not elsewhere classified	0.000	0.996	0.004
T50.5 Appetite depressants	0.000	0.996	0.004
T50.4 Drugs affecting uric acid metabolism	0.000	0.996	0.004
T50.3 Electrolytic, caloric and water-balance agents	0.000	0.996	0.004
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.000	0.996	0.004
T50.1 Loop [high-ceiling] diuretics	0.000	0.996	0.004
T50.0 Mineralocorticoids and their antagonists	0.000	0.996	0.004
H53.2 Diplopia	0.004	0.996	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.000	0.996	0.004
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.000	0.996	0.004
T38.9 Other and unspecified hormone antagonists	0.000	0.996	0.004
T38.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.996	0.004
T38.7 Androgens and anabolic congeners	0.000	0.996	0.004
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.000	0.996	0.004
T38.5 Other oestrogens and progestogens	0.000	0.996	0.004
T38.4 Oral contraceptives	0.000	0.996	0.004
T38.2 Antithyroid drugs	0.000	0.996	0.004
T38.1 Thyroid hormones and substitutes	0.000	0.996	0.004
T38.0 Glucocorticoids and synthetic analogues	0.000	0.996	0.004
Z42.0 Follow-up care involving plastic surgery of head and neck	0.004	0.996	0.000
M50.0 Cervical disk disorder with myelopathy	0.000	0.996	0.004
T36.0 Penicillins	0.000	0.996	0.004
S92.5 Fracture of other toe	0.004	0.996	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.000	0.996	0.003
T42.5 Mixed antiepileptics, not elsewhere classified	0.000	0.996	0.003
T42.3 Barbiturates	0.000	0.996	0.003
T42.2 Succinimides and oxazolidinediones	0.000	0.996	0.003
S92.01 Fracture of calcaneus (open)	0.003	0.996	0.000
K81.9 Cholecystitis, unspecified	0.004	0.996	0.000
S92.2 Fracture of other tarsal bone(s)	0.003	0.996	0.000
S90-S99 Injuries to the ankle and foot	0.004	0.996	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.000	0.996	0.003
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.000	0.996	0.003
S92.4 Fracture of great toe	0.003	0.996	0.000
T36.9 Systemic antibiotic, unspecified	0.000	0.996	0.003
T36.8 Other systemic antibiotics	0.000	0.996	0.003
T36.7 Antifungal antibiotics, systemically used	0.000	0.996	0.003
T36.6 Rifamycins	0.000	0.996	0.003
T36.5 Aminoglycosides	0.000	0.996	0.003
T36.4 Tetracyclines	0.000	0.996	0.003
T36.3 Macrolides	0.000	0.996	0.003
T36.2 Chloramphenicol group	0.000	0.996	0.003
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.000	0.996	0.003
M81.09 Postmenopausal osteoporosis (Site unspecified)	0.003	0.997	0.000
M81.08 Postmenopausal osteoporosis (Other)	0.003	0.997	0.000
M81.07 Postmenopausal osteoporosis (Ankle and foot)	0.003	0.997	0.000
M81.06 Postmenopausal osteoporosis (Lower leg)	0.003	0.997	0.000
M81.05 Postmenopausal osteoporosis (Pelvic region and thigh)	0.003	0.997	0.000
M81.04 Postmenopausal osteoporosis (Hand)	0.003	0.997	0.000
M81.03 Postmenopausal osteoporosis (Forearm)	0.003	0.997	0.000
M81.02 Postmenopausal osteoporosis (Upper arm)	0.003	0.997	0.000
M81.01 Postmenopausal osteoporosis (Shoulder region)	0.003	0.997	0.000
M81.00 Postmenopausal osteoporosis (Multiple sites)	0.003	0.997	0.000
M81.19 Postoophorectomy osteoporosis (Site unspecified)	0.003	0.997	0.000
M81.18 Postoophorectomy osteoporosis (Other)	0.003	0.997	0.000
M81.17 Postoophorectomy osteoporosis (Ankle and foot)	0.003	0.997	0.000
M81.16 Postoophorectomy osteoporosis (Lower leg)	0.003	0.997	0.000
M81.15 Postoophorectomy osteoporosis (Pelvic region and thigh)	0.003	0.997	0.000
M81.14 Postoophorectomy osteoporosis (Hand)	0.003	0.997	0.000
M81.13 Postoophorectomy osteoporosis (Forearm)	0.003	0.997	0.000
M81.12 Postoophorectomy osteoporosis (Upper arm)	0.003	0.997	0.000
M81.11 Postoophorectomy osteoporosis (Shoulder region)	0.003	0.997	0.000
M81.10 Postoophorectomy osteoporosis (Multiple sites)	0.003	0.997	0.000
M81.39 Postsurgical malabsorption osteoporosis (Site unspecified)	0.003	0.997	0.000
M81.38 Postsurgical malabsorption osteoporosis (Other)	0.003	0.997	0.000
M81.37 Postsurgical malabsorption osteoporosis (Ankle and foot)	0.003	0.997	0.000
M81.36 Postsurgical malabsorption osteoporosis (Lower leg)	0.003	0.997	0.000
M81.35 Postsurgical malabsorption osteoporosis (Pelvic region and thigh)	0.003	0.997	0.000
M81.34 Postsurgical malabsorption osteoporosis (Hand)	0.003	0.997	0.000
M81.33 Postsurgical malabsorption osteoporosis (Forearm)	0.003	0.997	0.000
M81.32 Postsurgical malabsorption osteoporosis (Upper arm)	0.003	0.997	0.000
M81.31 Postsurgical malabsorption osteoporosis (Shoulder region)	0.003	0.997	0.000
M81.30 Postsurgical malabsorption osteoporosis (Multiple sites)	0.003	0.997	0.000
M81.59 Idiopathic osteoporosis (Site unspecified)	0.003	0.997	0.000
M81.58 Idiopathic osteoporosis (Other)	0.003	0.997	0.000
M81.57 Idiopathic osteoporosis (Ankle and foot)	0.003	0.997	0.000
M81.56 Idiopathic osteoporosis (Lower leg)	0.003	0.997	0.000
M81.55 Idiopathic osteoporosis (Pelvic region and thigh)	0.003	0.997	0.000
M81.54 Idiopathic osteoporosis (Hand)	0.003	0.997	0.000
M81.53 Idiopathic osteoporosis (Forearm)	0.003	0.997	0.000
M81.52 Idiopathic osteoporosis (Upper arm)	0.003	0.997	0.000
M81.51 Idiopathic osteoporosis (Shoulder region)	0.003	0.997	0.000
M81.50 Idiopathic osteoporosis (Multiple sites)	0.003	0.997	0.000
M81.69 Localized osteoporosis [Lequesne] (Site unspecified)	0.003	0.997	0.000
M81.68 Localized osteoporosis [Lequesne] (Other)	0.003	0.997	0.000
M81.67 Localized osteoporosis [Lequesne] (Ankle and foot)	0.003	0.997	0.000
M81.66 Localized osteoporosis [Lequesne] (Lower leg)	0.003	0.997	0.000
M81.65 Localized osteoporosis [Lequesne] (Pelvic region and thigh)	0.003	0.997	0.000
M81.64 Localized osteoporosis [Lequesne] (Hand)	0.003	0.997	0.000
M81.63 Localized osteoporosis [Lequesne] (Forearm)	0.003	0.997	0.000
M81.62 Localized osteoporosis [Lequesne] (Upper arm)	0.003	0.997	0.000
M81.61 Localized osteoporosis [Lequesne] (Shoulder region)	0.003	0.997	0.000
M81.60 Localized osteoporosis [Lequesne] (Multiple sites)	0.003	0.997	0.000
M81.89 Other osteoporosis (Site unspecified)	0.003	0.997	0.000
M81.88 Other osteoporosis (Other)	0.003	0.997	0.000
M81.87 Other osteoporosis (Ankle and foot)	0.003	0.997	0.000
M81.86 Other osteoporosis (Lower leg)	0.003	0.997	0.000
M81.85 Other osteoporosis (Pelvic region and thigh)	0.003	0.997	0.000
M81.84 Other osteoporosis (Hand)	0.003	0.997	0.000
M81.83 Other osteoporosis (Forearm)	0.003	0.997	0.000
M81.82 Other osteoporosis (Upper arm)	0.003	0.997	0.000
M81.81 Other osteoporosis (Shoulder region)	0.003	0.997	0.000
M81.80 Other osteoporosis (Multiple sites)	0.003	0.997	0.000
M85.65 Other cyst of bone (Pelvic region and thigh)	0.003	0.997	0.000
C71.9 Brain, unspecified	0.003	0.997	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.000	0.997	0.003
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.000	0.997	0.003
T37.8 Other specified systemic anti-infectives and antiparasitics	0.000	0.997	0.003
T37.5 Antiviral drugs	0.000	0.997	0.003
T37.4 Anthelminthics	0.000	0.997	0.003
T37.3 Other antiprotozoal drugs	0.000	0.997	0.003
T37.2 Antimalarials and drugs acting on other blood protozoa	0.000	0.997	0.003
T37.1 Antimycobacterial drugs	0.000	0.997	0.003
T37.0 Sulphonamides	0.000	0.997	0.003
T41.5 Therapeutic gases	0.000	0.997	0.003
T41.4 Anaesthetic, unspecified	0.000	0.997	0.003
T41.3 Local anaesthetics	0.000	0.997	0.003
T41.2 Other and unspecified general anaesthetics	0.000	0.997	0.003
T41.1 Intravenous anaesthetics	0.000	0.997	0.003
T41.0 Inhaled anaesthetics	0.000	0.997	0.003
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.000	0.997	0.003
T48.6 Antiasthmatics, not elsewhere classified	0.000	0.997	0.003
T48.5 Anti-common-cold drugs	0.000	0.997	0.003
T48.4 Expectorants	0.000	0.997	0.003
T48.3 Antitussives	0.000	0.997	0.003
T48.2 Other and unspecified agents primarily acting on muscles	0.000	0.997	0.003
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.000	0.997	0.003
T48.0 Oxytocic drugs	0.000	0.997	0.003
T49.9 Topical agent, unspecified	0.000	0.997	0.003
T49.8 Other topical agents	0.000	0.997	0.003
T49.7 Dental drugs, topically applied	0.000	0.997	0.003
T49.6 Otorhinolaryngological drugs and preparations	0.000	0.997	0.003
T49.5 Ophthalmological drugs and preparations	0.000	0.997	0.003
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.000	0.997	0.003
T49.3 Emollients, demulcents and protectants	0.000	0.997	0.003
T49.2 Local astringents and local detergents	0.000	0.997	0.003
T49.1 Antipruritics	0.000	0.997	0.003
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.000	0.997	0.003
S92.7 Multiple fractures of foot	0.003	0.997	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.000	0.997	0.003
T46.8 Antivaricose drugs, including sclerosing agents	0.000	0.997	0.003
T46.7 Peripheral vasodilators	0.000	0.997	0.003
T46.5 Other antihypertensive drugs, not elsewhere classified	0.000	0.997	0.003
T46.3 Coronary vasodilators, not elsewhere classified	0.000	0.997	0.003
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.000	0.997	0.003
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.000	0.997	0.003
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.003	0.997	0.000
S90 Superficial injury of ankle and foot	0.003	0.997	0.000
C71.1 Frontal lobe	0.003	0.997	0.000
C71 Malignant neoplasm of brain	0.003	0.997	0.000
S92.9 Fracture of foot, unspecified	0.003	0.997	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.000	0.997	0.003
S99 Other and unspecified injuries of ankle and foot	0.003	0.997	0.000
S92.51 Fracture of other toe (open)	0.003	0.997	0.000
C71.0 Cerebrum, except lobes and ventricles	0.003	0.997	0.000
S92.20 Fracture of other tarsal bone(s) (closed)	0.003	0.997	0.000
T42.1 Iminostilbenes	0.000	0.997	0.003
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.003	0.997	0.000
S91 Open wound of ankle and foot	0.003	0.997	0.000
M81.29 Osteoporosis of disuse (Site unspecified)	0.003	0.997	0.000
M81.28 Osteoporosis of disuse (Other)	0.003	0.997	0.000
M81.27 Osteoporosis of disuse (Ankle and foot)	0.003	0.997	0.000
M81.26 Osteoporosis of disuse (Lower leg)	0.003	0.997	0.000
M81.25 Osteoporosis of disuse (Pelvic region and thigh)	0.003	0.997	0.000
M81.24 Osteoporosis of disuse (Hand)	0.003	0.997	0.000
M81.23 Osteoporosis of disuse (Forearm)	0.003	0.997	0.000
M81.22 Osteoporosis of disuse (Upper arm)	0.003	0.997	0.000
M81.21 Osteoporosis of disuse (Shoulder region)	0.003	0.997	0.000
S92.3 Fracture of metatarsal bone	0.003	0.997	0.000
S92.50 Fracture of other toe (closed)	0.003	0.997	0.000
T40.4 Other synthetic narcotics	0.000	0.997	0.003
T46.1 Calcium-channel blockers	0.000	0.997	0.003
S91.1 Open wound of toe(s) without damage to nail	0.003	0.997	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.000	0.997	0.003
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.000	0.997	0.003
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.997	0.003
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.000	0.997	0.003
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.000	0.997	0.003
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.000	0.997	0.003
T44.1 Other parasympathomimetics [cholinergics]	0.000	0.997	0.003
T44.0 Anticholinesterase agents	0.000	0.997	0.003
S92.40 Fracture of great toe (closed)	0.003	0.997	0.000
D43.0 Brain, supratentorial	0.003	0.997	0.000
M85.6 Other cyst of bone	0.003	0.997	0.000
S90.0 Contusion of ankle	0.003	0.997	0.000
D43.4 Spinal cord	0.003	0.997	0.000
T42.0 Hydantoin derivatives	0.000	0.997	0.003
S96 Injury of muscle and tendon at ankle and foot level	0.003	0.997	0.000
S27.20 Traumatic haemopneumothorax (without open wound into thoracic cavity)	0.003	0.997	0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.000	0.997	0.003
S90.8 Other superficial injuries of ankle and foot	0.003	0.997	0.000
S93.0 Dislocation of ankle joint	0.003	0.997	0.000
M80-M85 Disorders of bone density and structure	0.003	0.997	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.000	0.997	0.003
S92.21 Fracture of other tarsal bone(s) (open)	0.003	0.997	0.000
S99.8 Other specified injuries of ankle and foot	0.003	0.997	0.000
S98 Traumatic amputation of ankle and foot	0.003	0.997	0.000
S97 Crushing injury of ankle and foot	0.003	0.997	0.000
S95 Injury of blood vessels at ankle and foot level	0.003	0.997	0.000
S94 Injury of nerves at ankle and foot level	0.003	0.997	0.000
S92.1 Fracture of talus	0.003	0.997	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.000	0.997	0.003
T40.8 Lysergide [LSD]	0.000	0.997	0.003
T40.7 Cannabis (derivatives)	0.000	0.997	0.003
T40.3 Methadone	0.000	0.997	0.003
T40.1 Heroin	0.000	0.997	0.003
T40.0 Opium	0.000	0.997	0.003
S92.41 Fracture of great toe (open)	0.003	0.997	0.000
S90.3 Contusion of other and unspecified parts of foot	0.003	0.997	0.000
S99.9 Unspecified injury of ankle and foot	0.003	0.997	0.000
C71.4 Occipital lobe	0.003	0.997	0.000
S92.70 Multiple fractures of foot (closed)	0.003	0.997	0.000
T40.6 Other and unspecified narcotics	0.000	0.997	0.003
M85 Other disorders of bone density and structure	0.003	0.997	0.000
D43.9 Central nervous system, unspecified	0.003	0.997	0.000
D43.7 Other parts of central nervous system	0.003	0.997	0.000
D43.3 Cranial nerves	0.003	0.997	0.000
D43.1 Brain, infratentorial	0.003	0.997	0.000
S90.7 Multiple superficial injuries of ankle and foot	0.003	0.997	0.000
S90.2 Contusion of toe(s) with damage to nail	0.003	0.997	0.000
S90.1 Contusion of toe(s) without damage to nail	0.003	0.997	0.000
S92.71 Multiple fractures of foot (open)	0.002	0.997	0.000
T43.5 Other and unspecified antipsychotics and neuroleptics	0.000	0.997	0.003
S92.91 Fracture of foot, unspecified (open)	0.002	0.997	0.000
S92.90 Fracture of foot, unspecified (closed)	0.002	0.997	0.000
C71.7 Brain stem	0.003	0.997	0.000
C71.6 Cerebellum	0.003	0.997	0.000
C71.5 Cerebral ventricle	0.003	0.997	0.000
T43.6 Psychostimulants with abuse potential	0.000	0.997	0.003
C71.8 Overlapping lesion of brain	0.003	0.997	0.000
C18.0 Caecum	0.003	0.997	0.000
C71.3 Parietal lobe	0.003	0.997	0.000
D72.8 Other specified disorders of white blood cells	0.003	0.997	0.000
S91.3 Open wound of other parts of foot	0.003	0.997	0.000
S96.1 Injury of muscle and tendon of long extensor muscle of toe at ankle and foot level	0.002	0.997	0.000
T43.9 Psychotropic drug, unspecified	0.000	0.997	0.002
T43.8 Other psychotropic drugs, not elsewhere classified	0.000	0.997	0.002
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.000	0.997	0.002
S99.7 Multiple injuries of ankle and foot	0.002	0.997	0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.997	0.002
S90.9 Superficial injury of ankle and foot, unspecified	0.002	0.997	0.000
C83.0 Small cell (diffuse)	0.003	0.997	0.000
S93.4 Sprain and strain of ankle	0.002	0.997	0.000
S93.6 Sprain and strain of other and unspecified parts of foot	0.002	0.997	0.000
S93.5 Sprain and strain of toe(s)	0.002	0.997	0.000
S93.3 Dislocation of other and unspecified parts of foot	0.002	0.997	0.000
S93.2 Rupture of ligaments at ankle and foot level	0.002	0.997	0.000
N97 Female infertility	0.003	0.997	0.000
M81.20 Osteoporosis of disuse (Multiple sites)	0.002	0.997	0.000
S91.7 Multiple open wounds of ankle and foot	0.002	0.997	0.000
S91.2 Open wound of toe(s) with damage to nail	0.002	0.997	0.000
D44.4 Craniopharyngeal duct	0.002	0.997	0.000
D45 Polycythaemia vera	0.002	0.997	0.000
S92.31 Fracture of metatarsal bone (open)	0.002	0.998	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.000	0.998	0.002
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.002	0.998	0.000
M85.69 Other cyst of bone (Site unspecified)	0.002	0.998	0.000
M85.68 Other cyst of bone (Other)	0.002	0.998	0.000
M85.67 Other cyst of bone (Ankle and foot)	0.002	0.998	0.000
M85.66 Other cyst of bone (Lower leg)	0.002	0.998	0.000
M85.64 Other cyst of bone (Hand)	0.002	0.998	0.000
M85.63 Other cyst of bone (Forearm)	0.002	0.998	0.000
M85.62 Other cyst of bone (Upper arm)	0.002	0.998	0.000
M85.61 Other cyst of bone (Shoulder region)	0.002	0.998	0.000
M85.60 Other cyst of bone (Multiple sites)	0.002	0.998	0.000
D44.6 Carotid body	0.002	0.998	0.000
S93.1 Dislocation of toe(s)	0.002	0.998	0.000
M65.81 Other synovitis and tenosynovitis (Shoulder region)	0.002	0.998	0.000
C71.2 Temporal lobe	0.002	0.998	0.000
S96.8 Injury of other muscles and tendons at ankle and foot level	0.002	0.998	0.000
S96.7 Injury of multiple muscles and tendons at ankle and foot level	0.002	0.998	0.000
S96.2 Injury of intrinsic muscle and tendon at ankle and foot level	0.002	0.998	0.000
S96.0 Injury of muscle and tendon of long flexor muscle of toe at ankle and foot level	0.002	0.998	0.000
T40.5 Cocaine	0.000	0.998	0.002
H18 Other disorders of cornea	0.002	0.998	0.000
M83 Adult osteomalacia	0.002	0.998	0.000
M54.22 Cervicalgia (Cervical region)	0.000	0.998	0.002
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)	0.002	0.998	0.000
M65.86 Other synovitis and tenosynovitis (Lower leg)	0.002	0.998	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.002	0.998	0.000
S94.9 Injury of unspecified nerve at ankle and foot level	0.002	0.998	0.000
S94.8 Injury of other nerves at ankle and foot level	0.002	0.998	0.000
S94.7 Injury of multiple nerves at ankle and foot level	0.002	0.998	0.000
S94.3 Injury of cutaneous sensory nerve at ankle and foot level	0.002	0.998	0.000
S94.2 Injury of deep peroneal nerve at ankle and foot level	0.002	0.998	0.000
S94.1 Injury of medial plantar nerve	0.002	0.998	0.000
S94.0 Injury of lateral plantar nerve	0.002	0.998	0.000
S95.9 Injury of unspecified blood vessel at ankle and foot level	0.002	0.998	0.000
S95.8 Injury of other blood vessels at ankle and foot level	0.002	0.998	0.000
S95.7 Injury of multiple blood vessels at ankle and foot level	0.002	0.998	0.000
S95.2 Injury of dorsal vein of foot	0.002	0.998	0.000
S95.1 Injury of plantar artery of foot	0.002	0.998	0.000
S95.0 Injury of dorsal artery of foot	0.002	0.998	0.000
S97.8 Crushing injury of other parts of ankle and foot	0.002	0.998	0.000
S97.1 Crushing injury of toe(s)	0.002	0.998	0.000
S97.0 Crushing injury of ankle	0.002	0.998	0.000
S98.4 Traumatic amputation of foot, level unspecified	0.002	0.998	0.000
S98.3 Traumatic amputation of other parts of foot	0.002	0.998	0.000
S98.2 Traumatic amputation of two or more toes	0.002	0.998	0.000
S98.1 Traumatic amputation of one toe	0.002	0.998	0.000
S98.0 Traumatic amputation of foot at ankle level	0.002	0.998	0.000
C18.9 Colon, unspecified	0.002	0.998	0.000
M84 Disorders of continuity of bone	0.002	0.998	0.000
S92.11 Fracture of talus (open)	0.002	0.998	0.000
S96.9 Injury of unspecified muscle and tendon at ankle and foot level	0.002	0.998	0.000
D44.3 Pituitary gland	0.002	0.998	0.000
H18.3 Changes in corneal membranes	0.002	0.998	0.000
M65.8 Other synovitis and tenosynovitis	0.002	0.998	0.000
M84.0 Malunion of fracture	0.002	0.998	0.000
T40.2 Other opioids	0.000	0.998	0.002
G55.1 Nerve root and plexus compressions in intervertebral disk disorders	0.000	0.998	0.002
M84.07 Malunion of fracture (Ankle and foot)	0.002	0.998	0.000
M85.9 Disorder of bone density and structure, unspecified	0.002	0.998	0.000
M85.5 Aneurysmal bone cyst	0.002	0.998	0.000
M85.4 Solitary bone cyst	0.002	0.998	0.000
M85.3 Osteitis condensans	0.002	0.998	0.000
M85.2 Hyperostosis of skull	0.002	0.998	0.000
M85.1 Skeletal fluorosis	0.002	0.998	0.000
M80 Osteoporosis with pathological fracture	0.002	0.998	0.000
C69.3 Choroid	0.002	0.998	0.000
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)	0.002	0.998	0.000
M82 Osteoporosis in diseases classified elsewhere	0.002	0.998	0.000
X62.9 Unspecified place	0.000	0.998	0.002
S92.30 Fracture of metatarsal bone (closed)	0.002	0.998	0.000
H33.0 Retinal detachment with retinal break	0.002	0.998	0.000
N97.1 Female infertility of tubal origin	0.002	0.998	0.000
Z03.2 Observation for suspected mental and behavioural disorders	0.002	0.998	0.000
M84.05 Malunion of fracture (Pelvic region and thigh)	0.002	0.998	0.000
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)	0.002	0.998	0.000
J95.8 Other postprocedural respiratory disorders	0.000	0.998	0.002
H21.8 Other specified disorders of iris and ciliary body	0.002	0.998	0.000
T43.2 Other and unspecified antidepressants	0.000	0.998	0.002
S93.40 Sprain of unspecified ligament of ankle	0.002	0.998	0.000
N97.8 Female infertility of other origin	0.002	0.998	0.000
N97.4 Female infertility associated with male factors	0.002	0.998	0.000
N97.3 Female infertility of cervical origin	0.002	0.998	0.000
N97.2 Female infertility of uterine origin	0.002	0.998	0.000
N97.0 Female infertility associated with anovulation	0.002	0.998	0.000
M84.4 Pathological fracture, not elsewhere classified	0.002	0.998	0.000
M84.2 Delayed union of fracture	0.002	0.998	0.000
S91.0 Open wound of ankle	0.002	0.998	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.002	0.998	0.000
M65.87 Other synovitis and tenosynovitis (Ankle and foot)	0.002	0.998	0.000
D44.9 Endocrine gland, unspecified	0.002	0.998	0.000
D44.8 Pluriglandular involvement	0.002	0.998	0.000
D44.7 Aortic body and other paraganglia	0.002	0.998	0.000
D44.5 Pineal gland	0.002	0.998	0.000
D44.2 Parathyroid gland	0.002	0.998	0.000
D44.1 Adrenal gland	0.002	0.998	0.000
H18.1 Bullous keratopathy	0.002	0.998	0.000
R47.8 Other and unspecified speech disturbances	0.002	0.998	0.000
C83.3 Large cell (diffuse)	0.002	0.998	0.000
H18.0 Corneal pigmentations and deposits	0.002	0.998	0.000
C69 Malignant neoplasm of eye and adnexa	0.002	0.998	0.000
D39.1 Ovary	0.000	0.998	0.002
M65.83 Other synovitis and tenosynovitis (Forearm)	0.002	0.998	0.000
H18.9 Disorder of cornea, unspecified	0.002	0.998	0.000
O66.0 Obstructed labour due to shoulder dystocia	0.002	0.998	0.000
M84.48 Pathological fracture, not elsewhere classified (Other)	0.002	0.998	0.000
H18.7 Other corneal deformities	0.002	0.998	0.000
J06 Acute upper respiratory infections of multiple and unspecified sites	0.000	0.998	0.002
O22 Venous complications in pregnancy	0.002	0.998	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.002	0.998	0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.002	0.998	0.000
M80.59 Idiopathic osteoporosis with pathological fracture (Site unspecified)	0.002	0.998	0.000
M80.58 Idiopathic osteoporosis with pathological fracture (Other)	0.002	0.998	0.000
M80.57 Idiopathic osteoporosis with pathological fracture (Ankle and foot)	0.002	0.998	0.000
M80.56 Idiopathic osteoporosis with pathological fracture (Lower leg)	0.002	0.998	0.000
M80.55 Idiopathic osteoporosis with pathological fracture (Pelvic region and thigh)	0.002	0.998	0.000
M80.54 Idiopathic osteoporosis with pathological fracture (Hand)	0.002	0.998	0.000
M80.53 Idiopathic osteoporosis with pathological fracture (Forearm)	0.002	0.998	0.000
M80.51 Idiopathic osteoporosis with pathological fracture (Shoulder region)	0.002	0.998	0.000
M83.9 Adult osteomalacia, unspecified	0.002	0.998	0.000
M83.8 Other adult osteomalacia	0.002	0.998	0.000
M83.5 Other drug-induced osteomalacia in adults	0.002	0.998	0.000
M83.4 Aluminum bone disease	0.002	0.998	0.000
M83.3 Adult osteomalacia due to malnutrition	0.002	0.998	0.000
M83.2 Adult osteomalacia due to malabsorption	0.002	0.998	0.000
M83.1 Senile osteomalacia	0.002	0.998	0.000
M83.0 Puerperal osteomalacia	0.002	0.998	0.000
O22.0 Varicose veins of lower extremity in pregnancy	0.002	0.998	0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations