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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs7382794
log Bayes Factor = 103.948
Chromosome 6   position 32,734,030  (GRCh37) Explore rs7382794 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.001 0.999
E16.2 Hypoglycaemia, unspecified
0.000 0.001 0.999
E16 Other disorders of pancreatic internal secretion
0.000 0.001 0.999
L40.9 Psoriasis, unspecified
0.998 0.002 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.003 0.997
E10.2 With renal complications
0.000 0.006 0.994
E10.4 With neurological complications
0.000 0.037 0.963
E10.5 With peripheral circulatory complications
0.000 0.043 0.957
E50-E64 Other nutritional deficiencies
0.000 0.046 0.954
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.073 0.927
L40 Psoriasis
0.926 0.074 0.000
E55 Vitamin D deficiency
0.000 0.085 0.915
D86.9 Sarcoidosis, unspecified
0.000 0.090 0.910
G37 Other demyelinating diseases of central nervous system
0.000 0.097 0.903
E14 Unspecified diabetes mellitus
0.000 0.098 0.902
D86 Sarcoidosis
0.000 0.098 0.902
E55.9 Vitamin D deficiency, unspecified
0.000 0.113 0.887
D86.0 Sarcoidosis of lung
0.000 0.122 0.878
L40.5 Arthropathic psoriasis
0.836 0.164 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.167 0.833
L40.0 Psoriasis vulgaris
0.818 0.182 0.000
E10.0 With coma
0.000 0.187 0.813
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.190 0.809
E14.8 With unspecified complications
0.000 0.211 0.789
E10.7 With multiple complications
0.000 0.212 0.788
E40-E46 Malnutrition
0.000 0.215 0.785
D86.8 Sarcoidosis of other and combined sites
0.000 0.216 0.784
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.218 0.782
E14.3 With ophthalmic complications
0.000 0.221 0.779
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.234 0.766
D80-D89 Certain disorders involving the immune mechanism
0.000 0.240 0.760
E14.6 With other specified complications
0.000 0.246 0.754
E10.6 With other specified complications
0.000 0.247 0.753
E53 Deficiency of other B group vitamins
0.000 0.260 0.740
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.261 0.739
E10.8 With unspecified complications
0.000 0.273 0.727
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.274 0.726
D86.1 Sarcoidosis of lymph nodes
0.000 0.276 0.723
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
E51 Thiamine deficiency
0.000 0.293 0.707
E14.2 Withrenal complications
0.000 0.303 0.697
G36 Other acute disseminated demyelination
0.000 0.305 0.695
E61 Deficiency of other nutrient elements
0.000 0.307 0.693
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.310 0.690
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.312 0.688
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.316 0.684
E63 Other nutritional deficiencies
0.000 0.316 0.684
E50 Vitamin A deficiency
0.000 0.316 0.684
E60 Dietary zinc deficiency
0.000 0.316 0.684
E59 Dietary selenium deficiency
0.000 0.316 0.684
E54 Ascorbic acid deficiency
0.000 0.316 0.684
E52 Niacin deficiency [pellagra]
0.000 0.316 0.684
L40.1 Generalised pustular psoriasis
0.683 0.317 0.000
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.321 0.679
L40.4 Guttate psoriasis
0.677 0.322 0.000
L40.3 Pustulosis palmaris et plantaris
0.676 0.323 0.000
E56 Other vitamin deficiencies
0.000 0.326 0.674
E13 Other specified diabetes mellitus
0.000 0.327 0.673
L40.2 Acrodermatitis continua
0.664 0.336 0.000
E55.0 Rickets, active
0.000 0.344 0.656
G37.5 Concentric sclerosis [Balo]
0.000 0.353 0.647
G37.4 Subacute necrotising myelitis
0.000 0.353 0.647
G37.2 Central pontine myelinolysis
0.000 0.353 0.647
G37.1 Central demyelination of corpus callosum
0.000 0.353 0.647
G37.0 Diffuse sclerosis
0.000 0.353 0.647
E14.7 With multiple complications
0.000 0.353 0.646
E14.0 With coma
0.000 0.353 0.646
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.355 0.645
K90 Intestinal malabsorption
0.000 0.357 0.643
E58 Dietary calcium deficiency
0.000 0.361 0.639
E04 Other non-toxic goitre
0.000 0.365 0.635
E20-E35 Disorders of other endocrine glands
0.000 0.365 0.635
E46 Unspecified protein-energy malnutrition
0.000 0.369 0.631
E27 Other disorders of adrenal gland
0.000 0.371 0.629
E27.1 Primary adrenocortical insufficiency
0.000 0.371 0.629
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.372 0.628
E14.5 With peripheral circulatory complications
0.000 0.377 0.623
L40-L45 Papulosquamous disorders
0.598 0.378 0.024
M06.9 Rheumatoid arthritis, unspecified
0.615 0.385 0.000
M06 Other rheumatoid arthritis
0.607 0.393 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.605 0.395 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.398 0.602
E14.9 Without complications
0.000 0.410 0.590
D82 Immunodeficiency associated with other major defects
0.000 0.412 0.588
E61.2 Magnesium deficiency
0.000 0.412 0.588
E14.1 With ketoacidosis
0.000 0.420 0.580
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.579 0.421 0.000
M06.3 Rheumatoid nodule
0.575 0.425 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.427 0.573
L40.8 Other psoriasis
0.567 0.433 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.566 0.434 0.000
E06 Thyroiditis
0.000 0.436 0.564
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.437 0.563
E45 Retarded development following protein-energy malnutrition
0.000 0.437 0.563
E43 Unspecified severe protein-energy malnutrition
0.000 0.437 0.563
E42 Marasmic kwashiorkor
0.000 0.437 0.563
E41 Nutritional marasmus
0.000 0.437 0.563
E40 Kwashiorkor
0.000 0.437 0.563
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.441 0.559
M06.0 Seronegative rheumatoid arthritis
0.553 0.447 0.000
E04.2 Non-toxic multinodular goitre
0.000 0.447 0.553
D86.3 Sarcoidosis of skin
0.000 0.451 0.549
D81 Combined immunodeficiencies
0.000 0.455 0.545
E07 Other disorders of thyroid
0.000 0.466 0.534
E05.8 Other thyrotoxicosis
0.000 0.468 0.532
E53.1 Pyridoxine deficiency
0.000 0.469 0.531
E53.0 Riboflavin deficiency
0.000 0.469 0.531
E51.2 Wernicke's encephalopathy
0.000 0.471 0.529
G36.0 Neuromyelitis optica [Devic]
0.000 0.471 0.529
L42 Pityriasis rosea
0.514 0.475 0.011
E27.2 Addisonian crisis
0.000 0.477 0.523
D80 Immunodeficiency with predominantly antibody defects
0.000 0.477 0.522
D89.3 Immune reconstitution syndrome
0.000 0.480 0.520
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
M05-M14 Inflammatory polyarthropathies
0.511 0.489 0.000
D83 Common variable immunodeficiency
0.000 0.489 0.510
M05 Seropositive rheumatoid arthritis
0.510 0.490 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.510 0.490 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.509 0.491 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.493 0.507
E51.9 Thiamine deficiency, unspecified
0.000 0.493 0.507
E51.8 Other manifestations of thiamine deficiency
0.000 0.493 0.507
E51.1 Beriberi
0.000 0.493 0.507
M06.98 Rheumatoid arthritis, unspecified (Other)
0.505 0.495 0.000
G36.9 Acute disseminated demyelination, unspecified
0.000 0.502 0.498
G36.8 Other specified acute disseminated demyelination
0.000 0.502 0.498
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.502 0.498
E61.9 Deficiency of nutrient element, unspecified
0.000 0.503 0.497
E61.8 Deficiency of other specified nutrient elements
0.000 0.503 0.497
E61.7 Deficiency of multiple nutrient elements
0.000 0.503 0.497
E61.6 Vanadium deficiency
0.000 0.503 0.497
E61.5 Molybdenum deficiency
0.000 0.503 0.497
E61.4 Chromium deficiency
0.000 0.503 0.497
E61.3 Manganese deficiency
0.000 0.503 0.497
E61.0 Copper deficiency
0.000 0.503 0.497
E20 Hypoparathyroidism
0.000 0.504 0.496
E27.8 Other specified disorders of adrenal gland
0.000 0.505 0.495
M06.32 Rheumatoid nodule (Upper arm)
0.493 0.507 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.509 0.490
E50.8 Other manifestations of vitamin A deficiency
0.000 0.509 0.490
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.509 0.490
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.509 0.490
E50.5 Vitamin A deficiency with night blindness
0.000 0.509 0.490
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.509 0.490
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.509 0.490
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.509 0.490
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.509 0.490
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.509 0.490
E63.9 Nutritional deficiency, unspecified
0.000 0.509 0.490
E63.8 Other specified nutritional deficiencies
0.000 0.509 0.490
E63.1 Imbalance of constituents of food intake
0.000 0.509 0.490
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.509 0.490
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.509 0.490
E64.8 Sequelae of other nutritional deficiencies
0.000 0.509 0.490
E64.3 Sequelae of rickets
0.000 0.509 0.490
E64.2 Sequelae of vitamin C deficiency
0.000 0.509 0.490
E64.1 Sequelae of vitamin A deficiency
0.000 0.509 0.490
E64.0 Sequelae of protein-energy malnutrition
0.000 0.509 0.490
M06.34 Rheumatoid nodule (Hand)
0.491 0.509 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.513 0.487
E04.0 Non-toxic diffuse goitre
0.000 0.514 0.486
E13.9 Without complications
0.000 0.516 0.484
E56.9 Vitamin deficiency, unspecified
0.000 0.516 0.483
E56.8 Deficiency of other vitamins
0.000 0.516 0.483
E56.0 Deficiency of vitamin E
0.000 0.516 0.483
E13.8 With unspecified complications
0.000 0.517 0.483
E13.7 With multiple complications
0.000 0.517 0.483
E13.6 With other specified complications
0.000 0.517 0.483
E13.5 With peripheral circulatory complications
0.000 0.517 0.483
E13.4 With neurological complications
0.000 0.517 0.483
E13.2 With renal complications
0.000 0.517 0.483
E13.1 With ketoacidosis
0.000 0.517 0.483
E13.0 With coma
0.000 0.517 0.483
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.482 0.518 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.481 0.519 0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.521 0.479
E14.4 With neurological complications
0.000 0.522 0.478
E56.1 Deficiency of vitamin K
0.000 0.526 0.474
L44 Other papulosquamous disorders
0.458 0.526 0.016
E31 Polyglandular dysfunction
0.000 0.535 0.465
D82.1 Di George's syndrome
0.000 0.535 0.465
M06.33 Rheumatoid nodule (Forearm)
0.463 0.537 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.539 0.461
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.539 0.461
K90.1 Tropical sprue
0.000 0.539 0.461
E34 Other endocrine disorders
0.000 0.542 0.458
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.458 0.542 0.000
E16.1 Other hypoglycaemia
0.001 0.543 0.457
E04.8 Other specified non-toxic goitre
0.000 0.544 0.455
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.545 0.455
E32 Diseases of thymus
0.000 0.545 0.455
E30 Disorders of puberty, not elsewhere classified
0.000 0.545 0.455
E27.5 Adrenomedullary hyperfunction
0.000 0.549 0.451
E27.0 Other adrenocortical overactivity
0.000 0.549 0.451
L41 Parapsoriasis
0.429 0.554 0.017
L45 Papulosquamous disorders in diseases classified elsewhere
0.429 0.554 0.017
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.554 0.445
D84 Other immunodeficiencies
0.000 0.555 0.445
M06.36 Rheumatoid nodule (Lower leg)
0.445 0.555 0.000
M06.1 Adult-onset Still's disease
0.437 0.563 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.437 0.563 0.000
E13.3 With ophthalmic complications
0.000 0.563 0.437
E28 Ovarian dysfunction
0.000 0.563 0.437
M06.2 Rheumatoid bursitis
0.435 0.565 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.433 0.566 0.000
D89.1 Cryoglobulinaemia
0.000 0.567 0.433
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.431 0.569 0.000
M06.4 Inflammatory polyarthropathy
0.429 0.571 0.000
E06.5 Other chronic thyroiditis
0.000 0.572 0.427
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.425 0.575 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.577 0.423
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.578 0.422
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.578 0.422
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.578 0.422
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.578 0.422
D82.2 Immunodeficiency with short-limbed stature
0.000 0.578 0.422
D82.0 Wiskott-Aldrich syndrome
0.000 0.578 0.422
M06.30 Rheumatoid nodule (Multiple sites)
0.418 0.582 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.412 0.588 0.000
M06.38 Rheumatoid nodule (Other)
0.412 0.588 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.412 0.588 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.412 0.588 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.411 0.589 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.410 0.590 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.409 0.590 0.000
K90.8 Other intestinal malabsorption
0.000 0.595 0.404
E06.4 Drug-induced thyroiditis
0.000 0.596 0.404
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.596 0.404
E06.0 Acute thyroiditis
0.000 0.596 0.404
E44.1 Mild protein-energy malnutrition
0.000 0.596 0.404
E44.0 Moderate protein-energy malnutrition
0.000 0.596 0.404
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.403 0.597 0.000
M14 Arthropathies in other diseases classified elsewhere
0.402 0.598 0.000
E06.1 Subacute thyroiditis
0.000 0.598 0.402
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.401 0.599 0.000
M05.1 Rheumatoid lung disease
0.401 0.599 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.400 0.600 0.000
L43 Lichen planus
0.391 0.600 0.009
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.398 0.602 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.603 0.397
M06.08 Seronegative rheumatoid arthritis (Other)
0.397 0.603 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.397 0.603 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.397 0.603 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.397 0.603 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.397 0.603 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.395 0.605 0.000
M06.8 Other specified rheumatoid arthritis
0.395 0.605 0.000
E06.9 Thyroiditis, unspecified
0.000 0.608 0.392
D81.9 Combined immunodeficiency, unspecified
0.000 0.609 0.391
D81.8 Other combined immunodeficiencies
0.000 0.609 0.391
D81.7 Major histocompatibility complex class II deficiency
0.000 0.609 0.391
D81.6 Major histocompatibility complex class I deficiency
0.000 0.609 0.391
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.609 0.391
D81.4 Nezelof's syndrome
0.000 0.609 0.391
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.609 0.391
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.609 0.391
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.609 0.391
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.609 0.391
M05.8 Other seropositive rheumatoid arthritis
0.391 0.609 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.390 0.610 0.000
E34.8 Other specified endocrine disorders
0.000 0.610 0.390
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.387 0.613 0.000
M08 Juvenile arthritis
0.384 0.616 0.000
E04.9 Non-toxic goitre, unspecified
0.000 0.617 0.383
E07.1 Dyshormogenetic goitre
0.000 0.617 0.383
E07.0 Hypersecretion of calcitonin
0.000 0.617 0.383
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.617 0.383
E25 Adrenogenital disorders
0.000 0.619 0.381
E26 Hyperaldosteronism
0.000 0.621 0.378
H36.0 Diabetic retinopathy
0.000 0.625 0.375
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.625 0.375
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.625 0.375
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.625 0.375
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.625 0.375
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.625 0.375
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.625 0.375
L44.0 Pityriasis rubra pilaris
0.358 0.633 0.010
E27.9 Disorder of adrenal gland, unspecified
0.000 0.633 0.366
M09 Juvenile arthritis in diseases classified elsewhere
0.366 0.633 0.000
E24 Cushing's syndrome
0.000 0.634 0.366
D83.8 Other common variable immunodeficiencies
0.000 0.634 0.366
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.634 0.366
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.634 0.366
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.634 0.366
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.366 0.634 0.000
M05.0 Felty's syndrome
0.366 0.634 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.366 0.634 0.000
M11 Other crystal arthropathies
0.364 0.636 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.357 0.642 0.000
E20.8 Other hypoparathyroidism
0.000 0.644 0.356
E20.1 Pseudohypoparathyroidism
0.000 0.644 0.356
E20.0 Idiopathic hypoparathyroidism
0.000 0.644 0.356
E23 Hypofunction and other disorders of pituitary gland
0.000 0.646 0.354
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.650 0.350
M05.2 Rheumatoid vasculitis
0.348 0.651 0.000
E61.1 Iron deficiency
0.000 0.652 0.347
E28.3 Primary ovarian failure
0.000 0.653 0.347
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.347 0.653 0.000
E31.0 Autoimmune polyglandular failure
0.000 0.656 0.343
E07.8 Other specified disorders of thyroid
0.000 0.657 0.343
H36 Retinal disorders in diseases classified elsewhere
0.000 0.658 0.342
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.660 0.340
L44.9 Papulosquamous disorder, unspecified
0.328 0.660 0.011
L44.8 Other specified papulosquamous disorders
0.328 0.660 0.011
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.328 0.660 0.011
L44.3 Lichen ruber moniliformis
0.328 0.660 0.011
L44.2 Lichen striatus
0.328 0.660 0.011
L44.1 Lichen nitidus
0.328 0.660 0.011
M14.6 Neuropathic arthropathy
0.335 0.665 0.000
E31.9 Polyglandular dysfunction, unspecified
0.000 0.666 0.333
E31.8 Other polyglandular dysfunction
0.000 0.666 0.333
E31.1 Polyglandular hyperfunction
0.000 0.666 0.333
D83.9 Common variable immunodeficiency, unspecified
0.000 0.669 0.331
E34.5 Androgen resistance syndrome
0.000 0.671 0.329
E34.4 Constitutional tall stature
0.000 0.671 0.329
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.671 0.329
E34.1 Other hypersecretion of intestinal hormones
0.000 0.671 0.329
E30.9 Disorder of puberty, unspecified
0.000 0.673 0.326
E30.8 Other disorders of puberty
0.000 0.673 0.326
E30.1 Precocious puberty
0.000 0.673 0.326
E30.0 Delayed puberty
0.000 0.673 0.326
E32.9 Disease of thymus, unspecified
0.000 0.673 0.326
E32.8 Other diseases of thymus
0.000 0.673 0.326
E32.1 Abscess of thymus
0.000 0.673 0.326
E32.0 Persistent hyperplasia of thymus
0.000 0.673 0.326
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.673 0.326
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.673 0.326
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.673 0.326
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.325 0.675 0.000
M06.46 Inflammatory polyarthropathy (Lower leg)
0.324 0.676 0.000
E29 Testicular dysfunction
0.000 0.677 0.323
M05.19 Rheumatoid lung disease (Site unspecified)
0.322 0.678 0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.321 0.679 0.000
L41.9 Parapsoriasis, unspecified
0.307 0.680 0.012
L41.8 Other parapsoriasis
0.307 0.680 0.012
L41.5 Retiform parapsoriasis
0.307 0.680 0.012
L41.4 Large plaque parapsoriasis
0.307 0.680 0.012
L41.3 Small plaque parapsoriasis
0.307 0.680 0.012
L41.2 Lymphomatoid papulosis
0.307 0.680 0.012
L41.1 Pityriasis lichenoides chronica
0.307 0.680 0.012
L41.0 Pityriasis lichenoides et varioliformis acuta
0.307 0.680 0.012
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.681 0.319
H30-H36 Disorders of choroid and retina
0.000 0.681 0.319
E34.0 Carcinoid syndrome
0.000 0.681 0.318
E65-E68 Obesity and other hyperalimentation
0.000 0.683 0.316
M06.10 Adult-onset Still's disease (Multiple sites)
0.316 0.684 0.000
D84.8 Other specified immunodeficiencies
0.000 0.684 0.315
E34.3 Short stature, not elsewhere classified
0.000 0.685 0.315
M06.19 Adult-onset Still's disease (Site unspecified)
0.314 0.686 0.000
M06.18 Adult-onset Still's disease (Other)
0.314 0.686 0.000
M06.17 Adult-onset Still's disease (Ankle and foot)
0.314 0.686 0.000
M06.16 Adult-onset Still's disease (Lower leg)
0.314 0.686 0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.314 0.686 0.000
M06.14 Adult-onset Still's disease (Hand)
0.314 0.686 0.000
M06.13 Adult-onset Still's disease (Forearm)
0.314 0.686 0.000
M06.12 Adult-onset Still's disease (Upper arm)
0.314 0.686 0.000
M06.11 Adult-onset Still's disease (Shoulder region)
0.314 0.686 0.000
E28.9 Ovarian dysfunction, unspecified
0.000 0.687 0.313
E28.8 Other ovarian dysfunction
0.000 0.687 0.313
E28.1 Androgen excess
0.000 0.687 0.313
E28.0 Oestrogen excess
0.000 0.687 0.313
M06.29 Rheumatoid bursitis (Site unspecified)
0.312 0.688 0.000
M06.28 Rheumatoid bursitis (Other)
0.312 0.688 0.000
M06.27 Rheumatoid bursitis (Ankle and foot)
0.312 0.688 0.000
M06.26 Rheumatoid bursitis (Lower leg)
0.312 0.688 0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.312 0.688 0.000
M06.24 Rheumatoid bursitis (Hand)
0.312 0.688 0.000
M06.23 Rheumatoid bursitis (Forearm)
0.312 0.688 0.000
M06.22 Rheumatoid bursitis (Upper arm)
0.312 0.688 0.000
M06.21 Rheumatoid bursitis (Shoulder region)
0.312 0.688 0.000
M06.20 Rheumatoid bursitis (Multiple sites)
0.312 0.688 0.000
D84.1 Defects in the complement system
0.000 0.688 0.311
M07 Psoriatic and enteropathic arthropathies
0.311 0.689 0.000
H04 Disorders of lachrymal system
0.000 0.690 0.310
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.690 0.310
M12 Other specific arthropathies
0.308 0.692 0.000
M06.48 Inflammatory polyarthropathy (Other)
0.308 0.692 0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.308 0.692 0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.308 0.692 0.000
M06.44 Inflammatory polyarthropathy (Hand)
0.308 0.692 0.000
M06.43 Inflammatory polyarthropathy (Forearm)
0.308 0.692 0.000
M06.42 Inflammatory polyarthropathy (Upper arm)
0.308 0.692 0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.308 0.692 0.000
H33 Retinal detachments and breaks
0.000 0.693 0.307
L43.0 Hypertrophic lichen planus
0.301 0.693 0.006
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.304 0.695 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.696 0.304
Chapter VII Diseases of the eye and adnexa
0.000 0.697 0.303
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.700 0.300
H33.3 Retinal breaks without detachment
0.000 0.701 0.299
C21.0 Anus, unspecified
0.298 0.702 0.000
# Top node
0.000 0.704 0.296
H04.8 Other disorders of lachrymal system
0.000 0.704 0.296
M08.0 Juvenile rheumatoid arthritis
0.293 0.706 0.000
L20-L30 Dermatitis and eczema
0.000 0.708 0.292
C21.1 Anal canal
0.291 0.709 0.000
C21 Malignant neoplasm of anus and anal canal
0.289 0.711 0.000
M14.8 Arthropathies in other specified diseases classified elsewhere
0.288 0.712 0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.288 0.712 0.000
M14.4 Arthropathy in amyloidosis
0.288 0.712 0.000
M14.3 Lipoid dermatoarthritis
0.288 0.712 0.000
M14.1 Crystal arthropathy in other metabolic disorders
0.288 0.712 0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.288 0.712 0.000
E22 Hyperfunction of pituitary gland
0.000 0.712 0.288
Chapter VI Diseases of the nervous system
0.000 0.712 0.288
M05.18 Rheumatoid lung disease (Other)
0.287 0.713 0.000
M05.17 Rheumatoid lung disease (Ankle and foot)
0.287 0.713 0.000
M05.16 Rheumatoid lung disease (Lower leg)
0.287 0.713 0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)
0.287 0.713 0.000
M05.14 Rheumatoid lung disease (Hand)
0.287 0.713 0.000
M05.13 Rheumatoid lung disease (Forearm)
0.287 0.713 0.000
M05.12 Rheumatoid lung disease (Upper arm)
0.287 0.713 0.000
M05.11 Rheumatoid lung disease (Shoulder region)
0.287 0.713 0.000
M05.10 Rheumatoid lung disease (Multiple sites)
0.287 0.713 0.000
L60-L75 Disorders of skin appendages
0.000 0.713 0.287
L43.3 Subacute (active) lichen planus
0.280 0.713 0.007
L43.2 Lichenoid drug reaction
0.280 0.713 0.007
L43.1 Bullous lichen planus
0.280 0.713 0.007
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.286 0.714 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.714 0.286
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.715 0.285
M11.9 Crystal arthropathy, unspecified
0.285 0.715 0.000
M06.88 Other specified rheumatoid arthritis (Other)
0.283 0.717 0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.283 0.717 0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.283 0.717 0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.283 0.717 0.000
M06.84 Other specified rheumatoid arthritis (Hand)
0.283 0.717 0.000
M06.83 Other specified rheumatoid arthritis (Forearm)
0.283 0.717 0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.283 0.717 0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.283 0.717 0.000
H04.1 Other disorders of lachrymal gland
0.000 0.717 0.283
E23.2 Diabetes insipidus
0.000 0.717 0.283
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.717 0.283
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.281 0.719 0.000
M05.88 Other seropositive rheumatoid arthritis (Other)
0.280 0.719 0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)
0.280 0.719 0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)
0.280 0.719 0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)
0.280 0.719 0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)
0.280 0.719 0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)
0.280 0.719 0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)
0.280 0.719 0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)
0.280 0.719 0.000
E23.6 Other disorders of pituitary gland
0.000 0.722 0.278
M08.9 Juvenile arthritis, unspecified
0.276 0.724 0.000
M08.8 Other juvenile arthritis
0.276 0.724 0.000
M08.4 Pauciarticular juvenile arthritis
0.276 0.724 0.000
M08.3 Juvenile polyarthritis (seronegative)
0.276 0.724 0.000
M08.2 Juvenile arthritis with systemic onset
0.276 0.724 0.000
M08.1 Juvenile ankylosing spondylitis
0.276 0.724 0.000
L27 Dermatitis due to substances taken internally
0.000 0.726 0.274
L50-L54 Urticaria and erythema
0.000 0.727 0.273
E25.9 Adrenogenital disorder, unspecified
0.000 0.727 0.273
E25.8 Other adrenogenital disorders
0.000 0.727 0.273
E26.8 Other hyperaldosteronism
0.000 0.728 0.271
E26.1 Secondary hyperaldosteronism
0.000 0.728 0.271
E07.9 Disorder of thyroid, unspecified
0.000 0.729 0.271
M14.2 Diabetic arthropathy
0.270 0.730 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.730 0.270
H06.2 Dysthyroid exophthalmos
0.000 0.732 0.268
L71 Rosacea
0.000 0.733 0.267
D50-D53 Nutritional anaemias
0.000 0.734 0.266
L10-L14 Bullous disorders
0.000 0.734 0.266

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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