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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs74566653
log Bayes Factor = 14.3561
Chromosome 6   position 49,033,485  (GRCh37) Explore rs74566653 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.999 0.001 0.000
Chapter II Neoplasms
0.997 0.003 0.000
M15-M19 Arthrosis
0.996 0.004 0.000
M19 Other arthrosis
0.995 0.005 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.994 0.006 0.000
M20-M25 Other joint disorders
0.994 0.006 0.000
I60-I69 Cerebrovascular diseases
0.993 0.007 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.993 0.007 0.000
Chapter IX Diseases of the circulatory system
0.991 0.009 0.000
M19.9 Arthrosis, unspecified
0.989 0.011 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.982 0.018 0.000
Chapter VI Diseases of the nervous system
0.981 0.019 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.981 0.019 0.000
C15-C26 Malignant neoplasms of digestive organs
0.981 0.019 0.000
M25 Other joint disorders, not elsewhere classified
0.975 0.025 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.967 0.033 0.000
M05-M14 Inflammatory polyarthropathies
0.967 0.033 0.000
I60 Subarachnoid haemorrhage
0.966 0.034 0.000
C18 Malignant neoplasm of colon
0.959 0.041 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.959 0.041 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.959 0.041 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.956 0.044 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.956 0.044 0.000
M25.5 Pain in joint
0.950 0.050 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.942 0.058 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.939 0.061 0.000
D60-D64 Aplastic and other anaemias
0.935 0.065 0.000
R50-R69 General symptoms and signs
0.931 0.069 0.000
C78.7 Secondary malignant neoplasm of liver
0.930 0.070 0.000
G20-G26 Extrapyramidal and movement disorders
0.922 0.078 0.000
M18 Arthrosis of first carpometacarpal joint
0.920 0.080 0.000
O60-O75 Complications of labour and delivery
0.919 0.081 0.000
D50-D53 Nutritional anaemias
0.916 0.084 0.000
R47-R49 Symptoms and signs involving speech and voice
0.915 0.085 0.000
O00-O08 Pregnancy with abortive outcome
0.915 0.085 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.915 0.085 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.912 0.088 0.000
S40-S49 Injuries to the shoulder and upper arm
0.910 0.090 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.910 0.090 0.000
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.907 0.093 0.000
D64 Other anaemias
0.898 0.102 0.000
M70-M79 Other soft tissue disorders
0.896 0.104 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.896 0.104 0.000
R26 Abnormalities of gait and mobility
0.893 0.107 0.000
R69 Unknown and unspecified causes of morbidity
0.893 0.107 0.000
I61 Intracerebral haemorrhage
0.890 0.110 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.889 0.111 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.886 0.114 0.000
I63 Cerebral infarction
0.885 0.115 0.000
C18.0 Caecum
0.883 0.117 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.881 0.119 0.000
M19.0 Primary arthrosis of other joints
0.880 0.120 0.000
C18.7 Sigmoid colon
0.880 0.120 0.000
G20 Parkinson's disease
0.879 0.121 0.000
S70-S79 Injuries to the hip and thigh
0.876 0.124 0.000
G90-G99 Other disorders of the nervous system
0.876 0.124 0.000
O72 Postpartum haemorrhage
0.872 0.128 0.000
D64.9 Anaemia, unspecified
0.872 0.128 0.000
M80-M85 Disorders of bone density and structure
0.871 0.129 0.000
I69 Sequelae of cerebrovascular disease
0.867 0.133 0.000
M19.1 Posttraumatic arthrosis of other joints
0.867 0.133 0.000
R53 Malaise and fatigue
0.863 0.137 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.862 0.138 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.862 0.138 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.861 0.138 0.000
M24 Other specific joint derangements
0.861 0.139 0.000
M25.57 Pain in joint (Ankle and foot)
0.860 0.140 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.848 0.152 0.000
C78.2 Secondary malignant neoplasm of pleura
0.848 0.152 0.000
S42 Fracture of shoulder and upper arm
0.847 0.153 0.000
D50 Iron deficiency anaemia
0.846 0.154 0.000
Chapter I Certain infectious and parasitic diseases
0.846 0.154 0.000
S00-S09 Injuries to the head
0.845 0.155 0.000
M06 Other rheumatoid arthritis
0.841 0.159 0.000
R47 Speech disturbances, not elsewhere classified
0.839 0.161 0.000
T93 Sequelae of injuries of lower limb
0.837 0.163 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.836 0.164 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.833 0.167 0.000
C18.9 Colon, unspecified
0.830 0.170 0.000
M35 Other systemic involvement of connective tissue
0.829 0.171 0.000
O72.1 Other immediate postpartum haemorrhage
0.829 0.171 0.000
Q60-Q64 Congenital malformations of the urinary system
0.828 0.172 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.828 0.172 0.000
M25.7 Osteophyte
0.827 0.173 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.827 0.173 0.000
S20-S29 Injuries to the thorax
0.826 0.174 0.000
M05 Seropositive rheumatoid arthritis
0.823 0.177 0.000
M65-M68 Disorders of synovium and tendon
0.822 0.177 0.000
S10-S19 Injuries to the neck
0.822 0.178 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.822 0.178 0.000
C79 Secondary malignant neoplasm of other sites
0.820 0.180 0.000
I61.9 Intracerebral haemorrhage, unspecified
0.816 0.184 0.000
T79-T79 Certain early complications of trauma
0.816 0.184 0.000
M13 Other arthritis
0.815 0.185 0.000
G40-G47 Episodic and paroxysmal disorders
0.814 0.186 0.000
L98.9 Disorder of skin and subcutaneous tissue, unspecified
0.812 0.188 0.000
L98.8 Other specified disorders of skin and subcutaneous tissue
0.811 0.189 0.000
T81 Complications of procedures, not elsewhere classified
0.811 0.189 0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.811 0.189 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.807 0.193 0.000
M25.51 Pain in joint (Shoulder region)
0.807 0.193 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.806 0.194 0.000
O04 Medical abortion
0.805 0.194 0.000
M19.94 Arthrosis, unspecified (Hand)
0.805 0.195 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.802 0.198 0.000
I62 Other nontraumatic intracranial haemorrhage
0.801 0.199 0.000
Chapter XXII Codes for special purposes
0.800 0.200 0.000
C20 Malignant neoplasm of rectum
0.796 0.204 0.000
L50-L54 Urticaria and erythema
0.792 0.208 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.790 0.210 0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.789 0.211 0.000
O03 Spontaneous abortion
0.788 0.212 0.000
M07 Psoriatic and enteropathic arthropathies
0.788 0.212 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.786 0.214 0.000
R25 Abnormal involuntary movements
0.786 0.214 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.785 0.215 0.000
S42.0 Fracture of clavicle
0.785 0.215 0.000
M75 Shoulder lesions
0.784 0.216 0.000
D50.9 Iron deficiency anaemia, unspecified
0.781 0.219 0.000
R79 Other abnormal findings of blood chemistry
0.780 0.220 0.000
M34 Systemic sclerosis
0.778 0.222 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.778 0.222 0.000
M25.50 Pain in joint (Multiple sites)
0.778 0.222 0.000
Chapter V Mental and behavioural disorders
0.777 0.223 0.000
Chapter XX External causes of morbidity and mortality
0.777 0.223 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.776 0.224 0.000
M19.17 Post-traumatic arthrosis of other joints (Ankle and foot)
0.775 0.225 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.774 0.226 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.774 0.226 0.000
M21 Other acquired deformities of limbs
0.773 0.227 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.773 0.227 0.000
M45-M49 Spondylopathies
0.771 0.229 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.768 0.231 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.766 0.234 0.000
O62 Abnormalities of forces of labour
0.765 0.235 0.000
A00-A09 Intestinal infectious diseases
0.763 0.237 0.000
I63.9 Cerebral infarction, unspecified
0.762 0.238 0.000
L81 Other disorders of pigmentation
0.762 0.238 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.762 0.238 0.000
M11 Other crystal arthropathies
0.761 0.239 0.000
M50-M54 Other dorsopathies
0.760 0.240 0.000
L91 Hypertrophic disorders of skin
0.758 0.242 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.754 0.246 0.000
I67 Other cerebrovascular diseases
0.752 0.248 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.752 0.248 0.000
S90-S99 Injuries to the ankle and foot
0.752 0.248 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.752 0.248 0.000
S50-S59 Injuries to the elbow and forearm
0.751 0.248 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.751 0.249 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.749 0.251 0.000
L85 Other epidermal thickening
0.749 0.251 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.748 0.252 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.746 0.254 0.000
R68 Other general symptoms and signs
0.745 0.254 0.000
S72 Fracture of femur
0.743 0.257 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.743 0.257 0.000
O80-O84 Delivery
0.742 0.258 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.742 0.258 0.000
L90 Atrophic disorders of skin
0.741 0.259 0.000
S42.00 Fracture of clavicle (closed)
0.741 0.259 0.000
M81 Osteoporosis without pathological fracture
0.741 0.259 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.739 0.261 0.000
Q80-Q89 Other congenital malformations
0.738 0.262 0.000
D51 Vitamin B12 deficiency anaemia
0.737 0.263 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.737 0.263 0.000
M65 Synovitis and tenosynovitis
0.735 0.265 0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)
0.732 0.268 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.731 0.269 0.000
M91-M94 Chondropathies
0.731 0.269 0.000
M20 Acquired deformities of fingers and toes
0.731 0.269 0.000
Q50-Q56 Congenital malformations of genital organs
0.731 0.269 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.730 0.270 0.000
C15 Malignant neoplasm of oesophagus
0.730 0.270 0.000
M35.0 Sicca syndrome [Sjogren]
0.730 0.270 0.000
M06.9 Rheumatoid arthritis, unspecified
0.728 0.272 0.000
M86-M90 Other osteopathies
0.727 0.273 0.000
Chapter VII Diseases of the eye and adnexa
0.727 0.273 0.000
O04.9 Complete or unspecified, without complication
0.727 0.273 0.000
R47.0 Dysphasia and aphasia
0.727 0.273 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.726 0.274 0.000
M25.78 Osteophyte (Other)
0.725 0.275 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.725 0.275 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.725 0.275 0.000
R47.1 Dysarthria and anarthria
0.725 0.275 0.000
S40 Superficial injury of shoulder and upper arm
0.725 0.275 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.724 0.276 0.000
R61 Hyperhidrosis
0.722 0.278 0.000
L89 Decubitus ulcer
0.721 0.279 0.000
M31 Other necrotising vasculopathies
0.721 0.279 0.000
Q23 Congenital malformations of aortic and mitral valves
0.721 0.279 0.000
R49 Voice disturbances
0.721 0.279 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.720 0.280 0.000
G99.2 Myelopathy in diseases classified elsewhere
0.720 0.280 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.720 0.280 0.000
D80-D89 Certain disorders involving the immune mechanism
0.719 0.281 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.719 0.281 0.000
R52 Pain, not elsewhere classified
0.719 0.281 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
L98.0 Pyogenic granuloma
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.716 0.284 0.000
C25 Malignant neoplasm of pancreas
0.716 0.284 0.000
T98 Sequelae of other and unspecified effects of external causes
0.715 0.285 0.000
R54 Senility
0.715 0.285 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.715 0.285 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.714 0.285 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.714 0.285 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.714 0.285 0.000
O26.8 Other specified pregnancy-related conditions
0.715 0.285 0.000
M15 Polyarthrosis
0.714 0.286 0.000
G91 Hydrocephalus
0.714 0.286 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.714 0.286 0.000
M19.8 Other specified arthrosis
0.713 0.287 0.000
M19.2 Other secondary arthrosis
0.713 0.287 0.000
O03.4 Incomplete, without complication
0.713 0.287 0.000
M24.1 Other articular cartilage disorders
0.713 0.287 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.713 0.287 0.000
M25.54 Pain in joint (Hand)
0.713 0.287 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.713 0.287 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.712 0.287 0.000
M33 Dermatopolymyositis
0.712 0.287 0.000
M32 Systemic lupus erythematosus
0.712 0.287 0.000
M30 Polyarteritis nodosa and related conditions
0.712 0.287 0.000
C80 Malignant neoplasm without specification of site
0.713 0.287 0.000
S70 Superficial injury of hip and thigh
0.712 0.288 0.000
Q00-Q07 Congenital malformations of the nervous system
0.712 0.288 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.712 0.288 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.712 0.288 0.000
O85-O92 Complications predominantly related to the puerperium
0.712 0.288 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.712 0.288 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.710 0.289 0.000
I00-I02 Acute rheumatic fever
0.710 0.290 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.709 0.291 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.709 0.291 0.000
M25.8 Other specified joint disorders
0.709 0.291 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.709 0.291 0.000
S06 Intracranial injury
0.708 0.292 0.000
G24 Dystonia
0.708 0.292 0.000
R87 Abnormal findings in specimens from female genital organs
0.707 0.293 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.707 0.293 0.000
M13.9 Arthritis, unspecified
0.707 0.293 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.707 0.293 0.000
D55-D59 Haemolytic anaemias
0.704 0.296 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.704 0.296 0.000
R50 Fever of unknown origin
0.704 0.296 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.704 0.296 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.704 0.296 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.704 0.296 0.000
C21 Malignant neoplasm of anus and anal canal
0.704 0.296 0.000
C17 Malignant neoplasm of small intestine
0.704 0.296 0.000
C23 Malignant neoplasm of gallbladder
0.704 0.296 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.703 0.297 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.702 0.298 0.000
G70-G73 Diseases of myoneural junction and muscle
0.702 0.298 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.700 0.300 0.000
C18.3 Hepatic flexure
0.700 0.300 0.000
M25.9 Joint disorder, unspecified
0.699 0.301 0.000
M25.3 Other instability of joint
0.699 0.301 0.000
M25.2 Flail joint
0.699 0.301 0.000
M25.1 Fistula of joint
0.699 0.301 0.000
M25.0 Haemarthrosis
0.699 0.301 0.000
O21 Excessive vomiting in pregnancy
0.699 0.301 0.000
M25.53 Pain in joint (Forearm)
0.698 0.302 0.000
G30-G32 Other degenerative diseases of the nervous system
0.697 0.303 0.000
R76 Other abnormal immunological findings in serum
0.697 0.303 0.000
L82 Seborrhoeic keratosis
0.697 0.303 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.696 0.304 0.000
M19.01 Primary arthrosis of other joints (Shoulder region)
0.696 0.304 0.000
T93.2 Sequelae of other fractures of lower limb
0.695 0.305 0.000
D61 Other aplastic anaemias
0.694 0.306 0.000
R79.8 Other specified abnormal findings of blood chemistry
0.694 0.306 0.000
M14 Arthropathies in other diseases classified elsewhere
0.693 0.307 0.000
M12 Other specific arthropathies
0.693 0.307 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.693 0.307 0.000
M08 Juvenile arthritis
0.693 0.307 0.000
O73 Retained placenta and membranes, without haemorrhage
0.693 0.307 0.000
I60.8 Other subarachnoid haemorrhage
0.692 0.308 0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.692 0.308 0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.692 0.308 0.000
I60.5 Subarachnoid haemorrhage from vertebral artery
0.692 0.308 0.000
I60.4 Subarachnoid haemorrhage from basilar artery
0.692 0.308 0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.692 0.308 0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.692 0.308 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.692 0.308 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.691 0.308 0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.690 0.310 0.000
L92 Granulomatous disorders of skin and subcutaneous tissue
0.690 0.310 0.000
M84 Disorders of continuity of bone
0.690 0.310 0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.688 0.312 0.000
L53 Other erythematous conditions
0.688 0.312 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.688 0.312 0.000
C18.8 Overlapping lesion of colon
0.688 0.312 0.000
C18.5 Splenic flexure
0.688 0.312 0.000
C18.4 Transverse colon
0.688 0.312 0.000
C18.1 Appendix
0.688 0.312 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.688 0.312 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.688 0.312 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.688 0.312 0.000
G40 Epilepsy
0.687 0.313 0.000
Q61 Cystic kidney disease
0.687 0.313 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.686 0.314 0.000
L10-L14 Bullous disorders
0.686 0.314 0.000
B35-B49 Mycoses
0.686 0.314 0.000
R27 Other lack of coordination
0.686 0.314 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.685 0.314 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.685 0.315 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.685 0.315 0.000
Q35-Q37 Cleft lip and cleft palate
0.685 0.315 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.685 0.315 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.685 0.315 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.684 0.316 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.684 0.316 0.000
M22 Disorders of patella
0.683 0.317 0.000
M77 Other enthesopathies
0.682 0.317 0.000
M75.3 Calcific tendinitis of shoulder
0.682 0.318 0.000
M25.59 Pain in joint (Site unspecified)
0.681 0.319 0.000
M25.58 Pain in joint (Other)
0.681 0.319 0.000
M25.52 Pain in joint (Upper arm)
0.681 0.319 0.000
M24.0 Loose body in joint
0.681 0.319 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.681 0.319 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.679 0.321 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.677 0.323 0.000
O72.0 Third-stage haemorrhage
0.676 0.324 0.000
Q63 Other congenital malformations of kidney
0.676 0.324 0.000
R57 Shock, not elsewhere classified
0.676 0.324 0.000
D00-D09 In situ neoplasms
0.676 0.324 0.000
M71 Other bursopathies
0.676 0.324 0.000
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.675 0.325 0.000
L95 Vasculitis limited to skin, not elsewhere classified
0.675 0.325 0.000
L94 Other localised connective tissue disorders
0.675 0.325 0.000
L93 Lupus erythematosus
0.675 0.325 0.000
L87 Transepidermal elimination disorders
0.675 0.325 0.000
L88 Pyoderma gangrenosum
0.675 0.325 0.000
L86 Keratoderma in diseases classified elsewhere
0.675 0.325 0.000
L83 Acanthosis nigricans
0.675 0.325 0.000
L80 Vitiligo
0.675 0.325 0.000
O02 Other abnormal products of conception
0.674 0.325 0.000
M25.77 Osteophyte (Ankle and foot)
0.674 0.326 0.000
T87 Complications peculiar to reattachment and amputation
0.673 0.327 0.000
T86 Failure and rejection of transplanted organs and tissues
0.673 0.327 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.673 0.327 0.000
M25.4 Effusion of joint
0.673 0.327 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.672 0.327 0.000
M35.7 Hypermobility syndrome
0.672 0.328 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.670 0.329 0.000
S00 Superficial injury of head
0.670 0.330 0.000
R60 Oedema, not elsewhere classified
0.670 0.330 0.000
Q28 Other congenital malformations of circulatory system
0.670 0.330 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.670 0.330 0.000
C77.1 Intrathoracic lymph nodes
0.669 0.331 0.000
C60-C63 Malignant neoplasms of male genital organs
0.668 0.332 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.668 0.332 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.668 0.332 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.667 0.332 0.000
R62 Lack of expected normal physiological development
0.667 0.332 0.000
R64 Cachexia
0.667 0.332 0.000
R58 Haemorrhage, not elsewhere classified
0.667 0.332 0.000
M19.09 Primary arthrosis of other joints (Site unspecified)
0.667 0.333 0.000
T81.9 Unspecified complication of procedure
0.666 0.334 0.000
D62 Acute posthaemorrhagic anaemia
0.665 0.334 0.000
R26.3 Immobility
0.665 0.335 0.000
L98.4 Chronic ulcer of skin, not elsewhere classified
0.665 0.335 0.000
I05-I09 Chronic rheumatic heart diseases
0.664 0.336 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.664 0.336 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.663 0.337 0.000
M19.04 Primary arthrosis of other joints (Hand)
0.663 0.337 0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.662 0.338 0.000
S01 Open wound of head
0.662 0.338 0.000
S42.3 Fracture of shaft of humerus
0.662 0.338 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.662 0.338 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.662 0.338 0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.661 0.339 0.000
G23 Other degenerative diseases of basal ganglia
0.661 0.339 0.000
G21 Secondary Parkinsonism
0.661 0.339 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.661 0.339 0.000
G22 Parkinsonism in diseases classified elsewhere
0.661 0.339 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.661 0.339 0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint
0.659 0.340 0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral
0.659 0.340 0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint
0.659 0.340 0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral
0.659 0.340 0.000
M07.3 Other psoriatic arthropathies
0.659 0.341 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.659 0.341 0.000
O74 Complications of anaesthesia during labour and delivery
0.659 0.341 0.000
O71 Other obstetric trauma
0.659 0.341 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.659 0.341 0.000
O66 Other obstructed labour
0.659 0.341 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.659 0.341 0.000
O61 Failed induction of labour
0.659 0.341 0.000
O60 Preterm delivery
0.659 0.341 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.657 0.343 0.000
O82 Single delivery by Caesarean section
0.656 0.343 0.000
D53 Other nutritional anaemias
0.656 0.343 0.000
D52 Folate deficiency anaemia
0.656 0.343 0.000
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified
0.656 0.344 0.000
O08 Complications following abortion and ectopic and molar pregnancy
0.656 0.344 0.000
O07 Failed attempted abortion
0.656 0.344 0.000
O06 Unspecified abortion
0.656 0.344 0.000
O05 Other abortion
0.656 0.344 0.000
O01 Hydatidiform mole
0.656 0.344 0.000
R25.1 Tremor, unspecified
0.656 0.344 0.000
T95 Sequelae of burns, corrosions and frostbite
0.656 0.344 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.656 0.344 0.000
T91 Sequelae of injuries of neck and trunk
0.656 0.344 0.000
T90 Sequelae of injuries of head
0.656 0.344 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.656 0.344 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.656 0.344 0.000
O62.2 Other uterine inertia
0.656 0.344 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.656 0.344 0.000
T85.2 Mechanical complication of intraocular lens
0.655 0.344 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.655 0.345 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.655 0.345 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.655 0.345 0.000
C18.6 Descending colon
0.655 0.345 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.654 0.346 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.654 0.346 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.653 0.347 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.653 0.347 0.000
S48 Traumatic amputation of shoulder and upper arm
0.653 0.347 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.653 0.347 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.653 0.347 0.000
S44 Injury of nerves at shoulder and upper arm level
0.653 0.347 0.000
S41 Open wound of shoulder and upper arm
0.653 0.347 0.000
S47 Crushing injury of shoulder and upper arm
0.653 0.347 0.000
M06.0 Seronegative rheumatoid arthritis
0.652 0.348 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.652 0.348 0.000
D10-D36 Benign neoplasms
0.652 0.348 0.000
R56 Convulsions, not elsewhere classified
0.651 0.349 0.000
L98.7 Excessive and redundant skin and subcutaneous tissue
0.650 0.349 0.000
L98.6 Other infiltrative disorders of skin and subcutaneous tissue
0.650 0.349 0.000
L98.5 Mucinosis of skin
0.650 0.349 0.000
L98.3 Eosinophilic cellulitis [Wells]
0.650 0.349 0.000
L98.2 Febrile neutrophilic dermatosis [Sweet]
0.650 0.349 0.000
L98.1 Factitial dermatitis
0.650 0.349 0.000
T92 Sequelae of injuries of upper limb
0.650 0.350 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.650 0.350 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.649 0.351 0.000
M81.9 Osteoporosis, unspecified
0.648 0.352 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.647 0.353 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.647 0.353 0.000
L81.4 Other melanin hyperpigmentation
0.646 0.354 0.000
I67.2 Cerebral atherosclerosis
0.644 0.356 0.000
D64.8 Other specified anaemias
0.644 0.356 0.000
D64.4 Congenital dyserythropoietic anaemia
0.644 0.356 0.000
D64.3 Other sideroblastic anaemias
0.644 0.356 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.644 0.356 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.644 0.356 0.000
D64.0 Hereditary sideroblastic anaemia
0.644 0.356 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.643 0.357 0.000
O75.8 Other specified complications of labour and delivery
0.643 0.357 0.000
M76 Enthesopathies of lower limb, excluding foot
0.642 0.357 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.642 0.357 0.000
M80 Osteoporosis with pathological fracture
0.642 0.358 0.000
A09.0 Other and unspecified gastroenteritis and colitis of infectious origin
0.642 0.358 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.641 0.359 0.000
S19 Other and unspecified injuries of neck
0.641 0.359 0.000
Q23.1 Congenital insufficiency of aortic valve
0.641 0.359 0.000
R26.1 Paralytic gait
0.640 0.360 0.000
R26.0 Ataxic gait
0.640 0.360 0.000
M13.94 Arthritis, unspecified (Hand)
0.640 0.360 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.640 0.360 0.000
S51 Open wound of forearm
0.640 0.360 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.638 0.362 0.000
I69.3 Sequelae of cerebral infarction
0.638 0.362 0.000
I61.8 Other intracerebral haemorrhage
0.638 0.362 0.000
I61.6 Intracerebral haemorrhage, multiple localised
0.638 0.362 0.000
I61.5 Intracerebral haemorrhage, intraventricular
0.638 0.362 0.000
I61.4 Intracerebral haemorrhage in cerebellum
0.638 0.362 0.000
I61.3 Intracerebral haemorrhage in brain stem
0.638 0.362 0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.638 0.362 0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.638 0.362 0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.638 0.362 0.000
B15-B19 Viral hepatitis
0.638 0.362 0.000
R78 Findings of drugs and other substances, not normally found in blood
0.637 0.362 0.000
R77 Other abnormalities of plasma proteins
0.637 0.362 0.000
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity
0.637 0.362 0.000
R75 Laboratory evidence of human immunodeficiency virus [HIV]
0.637 0.362 0.000
R71 Abnormality of red blood cells
0.637 0.362 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.638 0.362 0.000
T66-T78 Other and unspecified effects of external causes
0.637 0.362 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.637 0.363 0.000
L91.8 Other hypertrophic disorders of skin
0.636 0.364 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.635 0.365 0.000
O29 Complications of anaesthesia during pregnancy
0.635 0.365 0.000
O28 Abnormal findings on antenatal screening of mother
0.635 0.365 0.000
O24 Diabetes mellitus in pregnancy
0.635 0.365 0.000
O23 Infections of genito-urinary tract in pregnancy
0.635 0.365 0.000
O22 Venous complications in pregnancy
0.635 0.365 0.000
O25 Malnutrition in pregnancy
0.635 0.365 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.635 0.365 0.000
I63.8 Other cerebral infarction
0.635 0.365 0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.635 0.365 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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