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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77009508
log Bayes Factor = 13.9319
Chromosome 6   position 161,004,972  (GRCh37) Explore rs77009508 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.001 0.999
I30-I52 Other forms of heart disease
0.000 0.001 0.999
I25.2 Old myocardial infarction
0.000 0.002 0.998
I51 Complications and ill-defined descriptions of heart disease
0.000 0.004 0.996
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.005 0.995
I20.0 Unstable angina
0.000 0.011 0.989
I50 Heart failure
0.000 0.011 0.989
I35 Nonrheumatic aortic valve disorders
0.000 0.011 0.989
I51.8 Other ill-defined heart diseases
0.000 0.012 0.988
I20.9 Angina pectoris, unspecified
0.000 0.014 0.986
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.015 0.985
I60-I69 Cerebrovascular diseases
0.000 0.019 0.981
I21 Acute myocardial infarction
0.000 0.019 0.981
I77 Other disorders of arteries and arterioles
0.000 0.028 0.972
I35.0 Aortic (valve) stenosis
0.000 0.037 0.963
I50.1 Left ventricular failure
0.000 0.045 0.955
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.049 0.951
I77.1 Stricture of artery
0.000 0.049 0.951
I51.9 Heart disease, unspecified
0.000 0.056 0.944
I73 Other peripheral vascular diseases
0.000 0.067 0.933
I73.9 Peripheral vascular disease, unspecified
0.000 0.085 0.915
I64 Stroke, not specified as haemorrhage or infarction
0.000 0.086 0.914
I63 Cerebral infarction
0.000 0.087 0.913
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.091 0.909
I50.9 Heart failure, unspecified
0.000 0.094 0.906
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.103 0.897
I63.9 Cerebral infarction, unspecified
0.000 0.110 0.890
I24 Other acute ischaemic heart diseases
0.000 0.124 0.876
I74 Arterial embolism and thrombosis
0.000 0.137 0.863
I77.8 Other specified disorders of arteries and arterioles
0.000 0.148 0.852
I35.8 Other aortic valve disorders
0.000 0.155 0.845
I33 Acute and subacute endocarditis
0.000 0.162 0.838
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.168 0.832
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.169 0.831
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.176 0.824
I69 Sequelae of cerebrovascular disease
0.000 0.182 0.818
I51.7 Cardiomegaly
0.000 0.185 0.815
Z95.1 Presence of aortocoronary bypass graft
0.000 0.188 0.812
I20.8 Other forms of angina pectoris
0.000 0.189 0.811
I62 Other nontraumatic intracranial haemorrhage
0.000 0.192 0.808
I25.5 Ischaemic cardiomyopathy
0.000 0.197 0.803
I50.0 Congestive heart failure
0.000 0.198 0.802
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.205 0.795
I25.3 Aneurysm of heart
0.000 0.205 0.795
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.210 0.790
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.210 0.790
Z95.4 Presence of other heart-valve replacement
0.000 0.218 0.782
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.229 0.771
I42 Cardiomyopathy
0.000 0.230 0.770
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.248 0.752
I22 Subsequent myocardial infarction
0.000 0.249 0.751
I67 Other cerebrovascular diseases
0.000 0.260 0.740
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.263 0.737
I05-I09 Chronic rheumatic heart diseases
0.000 0.267 0.733
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.270 0.730
I21.4 Acute subendocardial myocardial infarction
0.000 0.277 0.723
I33.0 Acute and subacute infective endocarditis
0.000 0.277 0.723
Z95.2 Presence of prosthetic heart valve
0.000 0.280 0.720
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I25.4 Coronary artery aneurysm
0.000 0.283 0.717
I23 Certain current complications following acute myocardial infarction
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.717
I52 Other heart disorders in diseases classified elsewhere
0.000 0.284 0.716
I48 Atrial fibrillation and flutter
0.000 0.284 0.716
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.284 0.716
I41 Myocarditis in diseases classified elsewhere
0.000 0.284 0.716
I40 Acute myocarditis
0.000 0.284 0.716
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.284 0.716
I32 Pericarditis in diseases classified elsewhere
0.000 0.284 0.716
I51.5 Myocardial degeneration
0.000 0.286 0.714
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.286 0.714
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.286 0.714
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.286 0.714
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.288 0.712
I77.0 Arteriovenous fistula, acquired
0.000 0.289 0.711
I69.3 Sequelae of cerebral infarction
0.000 0.289 0.711
Z95.3 Presence of xenogenic heart valve
0.000 0.294 0.706
I68 Cerebrovascular disorders in diseases classified elsewhere
0.000 0.297 0.703
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.000 0.297 0.703
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.297 0.703
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.000 0.297 0.703
I36 Nonrheumatic tricuspid valve disorders
0.000 0.298 0.702
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.303 0.697
I77.5 Necrosis of artery
0.000 0.303 0.697
I77.4 Coeliac artery compression syndrome
0.000 0.303 0.697
I77.3 Arterial fibromuscular dysplasia
0.000 0.303 0.697
I77.2 Rupture of artery
0.000 0.303 0.697
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.306 0.694
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.308 0.692
I51.6 Cardiovascular disease, unspecified
0.000 0.311 0.689
I63.8 Other cerebral infarction
0.000 0.312 0.688
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.317 0.683
I42.0 Dilated cardiomyopathy
0.000 0.323 0.677
I35.1 Aortic (valve) insufficiency
0.000 0.326 0.674
I67.9 Cerebrovascular disease, unspecified
0.000 0.327 0.673
I73.8 Other specified peripheral vascular diseases
0.000 0.328 0.671
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.331 0.669
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.333 0.667
I65.2 Occlusion and stenosis of carotid artery
0.000 0.335 0.665
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.000 0.335 0.664
I51.4 Myocarditis, unspecified
0.000 0.341 0.659
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.000 0.345 0.655
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.000 0.345 0.655
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.000 0.345 0.655
I77.6 Arteritis, unspecified
0.000 0.347 0.653
I74.5 Embolism and thrombosis of iliac artery
0.000 0.348 0.652
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.356 0.644
I45 Other conduction disorders
0.000 0.359 0.641
I74.8 Embolism and thrombosis of other arteries
0.000 0.364 0.636
I24.1 Dressler's syndrome
0.000 0.372 0.628
I30 Acute pericarditis
0.000 0.376 0.624
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.381 0.619
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.381 0.619
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.381 0.619
I69.1 Sequelae of intracerebral haemorrhage
0.000 0.387 0.613
I37 Pulmonary valve disorders
0.000 0.391 0.608
I33.9 Acute endocarditis, unspecified
0.000 0.399 0.601
I31 Other diseases of pericardium
0.000 0.406 0.594
I07 Rheumatic tricuspid valve diseases
0.000 0.406 0.594
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.406 0.593
I51.0 Cardiac septal defect, acquired
0.000 0.408 0.592
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.000 0.409 0.591
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.000 0.413 0.587
H65-H75 Diseases of middle ear and mastoid
0.586 0.414 0.000
I45.9 Conduction disorder, unspecified
0.000 0.417 0.583
I24.8 Other forms of acute ischaemic heart disease
0.000 0.417 0.583
I67.2 Cerebral atherosclerosis
0.000 0.418 0.582
I62.1 Nontraumatic extradural haemorrhage
0.000 0.421 0.579
H71 Cholesteatoma of middle ear
0.577 0.423 0.000
I42.6 Alcoholic cardiomyopathy
0.000 0.424 0.576
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.000 0.425 0.575
H66 Suppurative and unspecified otitis media
0.571 0.429 0.000
I42.8 Other cardiomyopathies
0.000 0.429 0.571
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.000 0.433 0.567
I65.8 Occlusion and stenosis of other precerebral artery
0.000 0.433 0.567
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.000 0.433 0.567
I65.1 Occlusion and stenosis of basilar artery
0.000 0.433 0.567
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.000 0.434 0.566
I72 Other aneurysm
0.000 0.437 0.563
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.000 0.438 0.562
I34 Nonrheumatic mitral valve disorders
0.000 0.440 0.559
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.441 0.559
I69.0 Sequelae of subarachnoid haemorrhage
0.000 0.445 0.555
H66.9 Otitis media, unspecified
0.554 0.446 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.448 0.552
I42.5 Other restrictive cardiomyopathy
0.000 0.448 0.552
I42.4 Endocardial fibroelastosis
0.000 0.448 0.552
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.448 0.552
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.000 0.452 0.548
I65.0 Occlusion and stenosis of vertebral artery
0.000 0.453 0.547
I70 Atherosclerosis
0.000 0.459 0.541
I20.1 Angina pectoris with documented spasm
0.000 0.460 0.539
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.461 0.539
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.000 0.463 0.537
I27 Other pulmonary heart diseases
0.000 0.464 0.536
H72 Perforation of tympanic membrane
0.532 0.468 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.000 0.469 0.531
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.000 0.469 0.531
I67.5 Moyamoya disease
0.000 0.469 0.531
I67.4 Hypertensive encephalopathy
0.000 0.469 0.531
I67.3 Progressive vascular leukoencephalopathy
0.000 0.469 0.531
I35.9 Aortic valve disorder, unspecified
0.000 0.471 0.529
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.471 0.529
I79.1 Aortitis in diseases classified elsewhere
0.000 0.471 0.529
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.471 0.529
I08 Multiple valve diseases
0.000 0.474 0.526
I06 Rheumatic aortic valve diseases
0.000 0.474 0.526
H74 Other disorders of middle ear and mastoid
0.526 0.474 0.000
I61 Intracerebral haemorrhage
0.000 0.476 0.524
I67.0 Dissection of cerebral arteries, nonruptured
0.000 0.480 0.520
H65 Nonsuppurative otitis media
0.520 0.480 0.000
I23.8 Other current complications following acute myocardial infarction
0.000 0.486 0.514
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.486 0.514
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.486 0.514
I02 Rheumatic chorea
0.000 0.486 0.514
I01 Rheumatic fever with heart involvement
0.000 0.486 0.514
I00 Rheumatic fever without mention of heart involvement
0.000 0.486 0.514
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.486 0.513
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.513
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.486 0.513
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.486 0.513
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.486 0.513
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.486 0.513
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.486 0.513
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.486 0.513
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.486 0.513
I40.9 Acute myocarditis, unspecified
0.000 0.486 0.513
I40.8 Other acute myocarditis
0.000 0.486 0.513
I40.1 Isolated myocarditis
0.000 0.486 0.513
I40.0 Infective myocarditis
0.000 0.486 0.513
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.486 0.513
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.513
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.486 0.513
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.486 0.513
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.486 0.513
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.486 0.513
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.486 0.513
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.486 0.513
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.486 0.513
I48.4 Atypical atrial flutter
0.000 0.486 0.513
I48.3 Typical atrial flutter
0.000 0.486 0.513
I48.2 Chronic atrial fibrillation
0.000 0.486 0.513
I48.1 Persistent atrial fibrillation
0.000 0.486 0.513
I48.0 Paroxysmal atrial fibrillation
0.000 0.486 0.513
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.486 0.513
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.486 0.513
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.486 0.513
Z95.0 Presence of cardiac pacemaker
0.000 0.494 0.506
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.000 0.495 0.504
I66.8 Occlusion and stenosis of other cerebral artery
0.000 0.495 0.504
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.000 0.495 0.504
I66.3 Occlusion and stenosis of cerebellar arteries
0.000 0.495 0.504
I66.2 Occlusion and stenosis of posterior cerebral artery
0.000 0.495 0.504
I66.1 Occlusion and stenosis of anterior cerebral artery
0.000 0.495 0.504
I66.0 Occlusion and stenosis of middle cerebral artery
0.000 0.495 0.504
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.000 0.495 0.504
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.000 0.495 0.504
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.000 0.495 0.504
I68.0 Cerebral amyloid angiopathy
0.000 0.495 0.504
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.496 0.504
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.496 0.504
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.496 0.504
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.496 0.504
I42.9 Cardiomyopathy, unspecified
0.000 0.500 0.500
I45.8 Other specified conduction disorders
0.000 0.501 0.499
I46 Cardiac arrest
0.000 0.501 0.499
I05 Rheumatic mitral valve diseases
0.000 0.505 0.495
I07.1 Tricuspid insufficiency
0.000 0.505 0.495
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.510 0.490
I22.8 Subsequent myocardial infarction of other sites
0.000 0.513 0.487
I78 Diseases of capillaries
0.000 0.514 0.486
I09 Other rheumatic heart diseases
0.000 0.515 0.485
H73 Other disorders of tympanic membrane
0.483 0.516 0.000
I08.0 Disorders of both mitral and aortic valves
0.000 0.517 0.483
I28 Other diseases of pulmonary vessels
0.000 0.522 0.478
I27.2 Other secondary pulmonary hypertension
0.000 0.523 0.477
H65.2 Chronic serous otitis media
0.472 0.528 0.000
I67.8 Other specified cerebrovascular diseases
0.000 0.529 0.471
I30.1 Infective pericarditis
0.000 0.534 0.465
I45.4 Nonspecific intraventricular block
0.000 0.538 0.462
I45.0 Right fascicular block
0.000 0.540 0.459
I44 Atrioventricular and left bundle-branch block
0.000 0.541 0.459
H72.9 Perforation of tympanic membrane, unspecified
0.457 0.543 0.000
I72.4 Aneurysm of artery of lower extremity
0.000 0.544 0.456
H74.3 Other acquired abnormalities of ear ossicles
0.453 0.546 0.000
H72.2 Other marginal perforations of tympanic membrane
0.451 0.549 0.000
I21.9 Acute myocardial infarction, unspecified
0.000 0.550 0.450
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.552 0.448
I30.8 Other forms of acute pericarditis
0.000 0.553 0.447
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.553 0.447
H66.4 Suppurative otitis media, unspecified
0.446 0.554 0.000
I37.9 Pulmonary valve disorder, unspecified
0.000 0.563 0.436
I37.8 Other pulmonary valve disorders
0.000 0.563 0.436
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.563 0.436
I37.0 Pulmonary valve stenosis
0.000 0.563 0.436
H66.1 Chronic tubotympanic suppurative otitis media
0.436 0.564 0.000
I34.1 Mitral (valve) prolapse
0.000 0.565 0.435
I08.8 Other multiple valve diseases
0.000 0.566 0.434
H74.9 Disorder of middle ear and mastoid, unspecified
0.431 0.569 0.000
I31.8 Other specified diseases of pericardium
0.000 0.574 0.426
I31.2 Haemopericardium, not elsewhere classified
0.000 0.574 0.426
I31.1 Chronic constrictive pericarditis
0.000 0.574 0.426
I31.0 Chronic adhesive pericarditis
0.000 0.574 0.426
I07.9 Tricuspid valve disease, unspecified
0.000 0.574 0.426
I07.8 Other tricuspid valve diseases
0.000 0.574 0.426
I07.2 Tricuspid stenosis with insufficiency
0.000 0.574 0.426
I07.0 Tricuspid stenosis
0.000 0.574 0.426
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.420 0.580 0.000
H68 Eustachian salpingitis and obstruction
0.420 0.580 0.000
H67 Otitis media in diseases classified elsewhere
0.420 0.580 0.000
I45.1 Other and unspecified right bundle-branch block
0.000 0.581 0.419
H66.3 Other chronic suppurative otitis media
0.418 0.582 0.000
H70 Mastoiditis and related conditions
0.411 0.589 0.000
H73.8 Other specified disorders of tympanic membrane
0.410 0.590 0.000
H66.2 Chronic atticoantral suppurative otitis media
0.409 0.590 0.000
H66.0 Acute suppurative otitis media
0.409 0.590 0.000
I42.2 Other hypertrophic cardiomyopathy
0.000 0.593 0.407
H72.8 Other perforations of tympanic membrane
0.406 0.594 0.000
I72.9 Aneurysm of unspecified site
0.000 0.596 0.404
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.596 0.404
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.596 0.404
I72.2 Aneurysm of renal artery
0.000 0.596 0.404
I72.1 Aneurysm of artery of upper extremity
0.000 0.596 0.404
I34.8 Other nonrheumatic mitral valve disorders
0.000 0.599 0.401
I34.2 Nonrheumatic mitral (valve) stenosis
0.000 0.599 0.401
H65.4 Other chronic nonsuppurative otitis media
0.400 0.600 0.000
I45.6 Preexcitation syndrome
0.000 0.601 0.399
H74.8 Other specified disorders of middle ear and mastoid
0.399 0.601 0.000
I44.3 Other and unspecified atrioventricular block
0.000 0.603 0.397
H74.4 Polyp of middle ear
0.395 0.605 0.000
I31.9 Disease of pericardium, unspecified
0.000 0.606 0.393
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.000 0.611 0.389
I70.9 Generalised and unspecified atherosclerosis
0.000 0.612 0.388
I70.8 Atherosclerosis of other arteries
0.000 0.612 0.388
H65.9 Nonsuppurative otitis media, unspecified
0.388 0.612 0.000
I73.0 Raynaud's syndrome
0.000 0.614 0.386
I05.9 Mitral valve disease, unspecified
0.000 0.614 0.386
I27.8 Other specified pulmonary heart diseases
0.000 0.616 0.384
I27.1 Kyphoscoliotic heart disease
0.000 0.616 0.384
H72.1 Attic perforation of tympanic membrane
0.382 0.618 0.000
I08.9 Multiple valve disease, unspecified
0.000 0.623 0.377
I38 Endocarditis, valve unspecified
0.000 0.623 0.377
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.623 0.377
I06.8 Other rheumatic aortic valve diseases
0.000 0.623 0.377
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.623 0.377
I06.1 Rheumatic aortic insufficiency
0.000 0.623 0.377
I06.0 Rheumatic aortic stenosis
0.000 0.623 0.377
H74.2 Discontinuity and dislocation of ear ossicles
0.377 0.623 0.000
H74.1 Adhesive middle ear disease
0.377 0.623 0.000
I61.6 Intracerebral haemorrhage, multiple localised
0.000 0.624 0.376
I61.4 Intracerebral haemorrhage in cerebellum
0.000 0.624 0.376
I61.3 Intracerebral haemorrhage in brain stem
0.000 0.624 0.376
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.000 0.624 0.376
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.625 0.375
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.000 0.625 0.375
I45.5 Other specified heart block
0.000 0.626 0.374
H65.1 Other acute nonsuppurative otitis media
0.373 0.627 0.000
H65.0 Acute serous otitis media
0.373 0.627 0.000
I61.5 Intracerebral haemorrhage, intraventricular
0.000 0.630 0.370
I72.8 Aneurysm of other specified arteries
0.000 0.631 0.369
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.631 0.368
I01.8 Other acute rheumatic heart disease
0.000 0.631 0.368
I01.2 Acute rheumatic myocarditis
0.000 0.631 0.368
I01.1 Acute rheumatic endocarditis
0.000 0.631 0.368
I01.0 Acute rheumatic pericarditis
0.000 0.631 0.368
I02.9 Rheumatic chorea without heart involvement
0.000 0.631 0.368
I02.0 Rheumatic chorea with heart involvement
0.000 0.631 0.368
I70.1 Atherosclerosis of renal artery
0.000 0.634 0.366
I45.2 Bifascicular block
0.000 0.636 0.364
H72.0 Central perforation of tympanic membrane
0.362 0.638 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.640 0.360
I46.1 Sudden cardiac death, so described
0.000 0.642 0.358
I27.0 Primary pulmonary hypertension
0.000 0.644 0.356
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.645 0.355
I05.8 Other mitral valve diseases
0.000 0.645 0.355
I45.3 Trifascicular block
0.000 0.645 0.355
I05.1 Rheumatic mitral insufficiency
0.000 0.646 0.354
Chapter VIII Diseases of the ear and mastoid process
0.352 0.648 0.000
I31.3 Pericardial effusion (noninflammatory)
0.000 0.649 0.351
I60 Subarachnoid haemorrhage
0.000 0.651 0.349
I78.9 Disease of capillaries, unspecified
0.000 0.651 0.348
I09.8 Other specified rheumatic heart diseases
0.000 0.652 0.348
I09.2 Chronic rheumatic pericarditis
0.000 0.652 0.348
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.652 0.348
I09.0 Rheumatic myocarditis
0.000 0.652 0.348
H73.9 Disorder of tympanic membrane, unspecified
0.347 0.653 0.000
H73.1 Chronic myringitis
0.347 0.653 0.000
H73.0 Acute myringitis
0.347 0.653 0.000
I70.0 Atherosclerosis of aorta
0.000 0.654 0.346
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.000 0.657 0.343
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.657 0.343
I28.8 Other specified diseases of pulmonary vessels
0.000 0.657 0.343
I28.1 Aneurysm of pulmonary artery
0.000 0.657 0.343
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.657 0.343
H74.0 Tympanosclerosis
0.342 0.657 0.000
H69 Other disorders of Eustachian tube
0.341 0.659 0.000
I46.9 Cardiac arrest, unspecified
0.000 0.663 0.337
I27.9 Pulmonary heart disease, unspecified
0.000 0.668 0.332
I44.1 Atrioventricular block, second degree
0.000 0.670 0.330
I44.5 Left posterior fascicular block
0.000 0.671 0.329
I44.4 Left anterior fascicular block
0.000 0.671 0.329
I37.1 Pulmonary valve insufficiency
0.001 0.671 0.328
I78.8 Other diseases of capillaries
0.000 0.673 0.326
H65.3 Chronic mucoid otitis media
0.326 0.674 0.000
I30.9 Acute pericarditis, unspecified
0.000 0.676 0.324
I72.0 Aneurysm of carotid artery
0.000 0.676 0.323
I26 Pulmonary embolism
0.000 0.676 0.324
I71 Aortic aneurysm and dissection
0.000 0.676 0.323
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.677 0.323
I05.0 Mitral stenosis
0.000 0.678 0.322
I61.8 Other intracerebral haemorrhage
0.000 0.681 0.319
I72.3 Aneurysm of iliac artery
0.000 0.681 0.318
I05.2 Mitral stenosis with insufficiency
0.000 0.682 0.318
H90-H95 Other disorders of ear
0.315 0.685 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.687 0.312
I09.9 Rheumatic heart disease, unspecified
0.000 0.693 0.307
I44.0 Atrioventricular block, first degree
0.000 0.699 0.301
H67.8 Otitis media in other diseases classified elsewhere
0.301 0.699 0.000
H67.1 Otitis media in viral diseases classified elsewhere
0.301 0.699 0.000
H67.0 Otitis media in bacterial diseases classified elsewhere
0.301 0.699 0.000
H68.1 Obstruction of Eustachian tube
0.301 0.699 0.000
H68.0 Eustachian salpingitis
0.301 0.699 0.000
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere
0.301 0.699 0.000
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
0.301 0.699 0.000
H70.8 Other mastoiditis and related conditions
0.295 0.705 0.000
H70.2 Petrositis
0.295 0.705 0.000
H70.1 Chronic mastoiditis
0.295 0.705 0.000
H70.0 Acute mastoiditis
0.295 0.705 0.000
H60-H62 Diseases of external ear
0.294 0.706 0.000
H90 Conductive and sensorineural hearing loss
0.294 0.706 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.708 0.292
I44.6 Other and unspecified fascicular block
0.000 0.713 0.287
H70.9 Mastoiditis, unspecified
0.286 0.713 0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.000 0.719 0.281
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.721 0.278
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.721 0.278
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.721 0.278
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.721 0.278
I61.9 Intracerebral haemorrhage, unspecified
0.000 0.724 0.276
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.271 0.729 0.000
I34.0 Mitral (valve) insufficiency
0.000 0.734 0.266
H61 Other disorders of external ear
0.263 0.737 0.000
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.737 0.262
I10-I15 Hypertensive diseases
0.000 0.743 0.257
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.000 0.749 0.250
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.000 0.749 0.250
I60.5 Subarachnoid haemorrhage from vertebral artery
0.000 0.749 0.250
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.000 0.749 0.250
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.248 0.751 0.000
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.751 0.248
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.246 0.754 0.000
H69.0 Patulous Eustachian tube
0.245 0.755 0.000
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.760 0.240
H93 Other disorders of ear, not elsewhere classified
0.237 0.763 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.764 0.235
H90.8 Mixed conductive and sensorineural hearing loss, unspecified
0.234 0.765 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.768 0.232
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.768 0.232
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.768 0.232
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.768 0.232
H90.5 Sensorineural hearing loss, unspecified
0.230 0.770 0.000
I44.2 Atrioventricular block, complete
0.000 0.770 0.230
I60.4 Subarachnoid haemorrhage from basilar artery
0.001 0.772 0.228
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.772 0.228
H61.1 Non-infective disorders of pinna
0.228 0.772 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.226 0.774 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.775 0.225
I99 Other and unspecified disorders of circulatory system
0.000 0.775 0.224
I60.8 Other subarachnoid haemorrhage
0.001 0.776 0.224
H69.8 Other specified disorders of Eustachian tube
0.221 0.779 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.780 0.220
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.781 0.218
H90.2 Conductive hearing loss, unspecified
0.218 0.782 0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.214 0.786 0.000
H61.2 Impacted cerumen
0.214 0.786 0.000
H62 Disorders of external ear in diseases classified elsewhere
0.211 0.789 0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral
0.211 0.789 0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.791 0.209
H61.3 Acquired stenosis of external ear canal
0.209 0.791 0.000
I67.1 Cerebral aneurysm, nonruptured
0.001 0.792 0.207
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.001 0.792 0.207
I70.00 Atherosclerosis of aorta (without gangrene)
0.001 0.793 0.206
H95.0 Recurrent cholesteatoma of postmastoidectomy cavity
0.204 0.796 0.000
H61.8 Other specified disorders of external ear
0.203 0.797 0.000
H69.9 Eustachian tube disorder, unspecified
0.201 0.799 0.000
H92 Otalgia and effusion of ear
0.199 0.801 0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.001 0.802 0.198
H90.0 Conductive hearing loss, bilateral
0.194 0.806 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.000 0.806 0.194
H93.8 Other specified disorders of ear
0.188 0.812 0.000
H61.9 Disorder of external ear, unspecified
0.186 0.814 0.000
I46.0 Cardiac arrest with successful resuscitation
0.000 0.814 0.186
H60 Otitis externa
0.185 0.814 0.000
I13 Hypertensive heart and renal disease
0.000 0.815 0.184
H91 Other hearing loss
0.180 0.820 0.000
I15 Secondary hypertension
0.000 0.821 0.179
H95.9 Postprocedural disorder of ear and mastoid process, unspecified
0.178 0.822 0.000
H95.8 Other postprocedural disorders of ear and mastoid process
0.178 0.822 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.823 0.176
I11 Hypertensive heart disease
0.000 0.824 0.176
H95.1 Other disorders following mastoidectomy
0.173 0.826 0.000
I95 Hypotension
0.000 0.826 0.173
I44.7 Left bundle-branch block, unspecified
0.000 0.828 0.172
H93.1 Tinnitus
0.172 0.828 0.000
I97.1 Other functional disturbances following cardiac surgery
0.000 0.829 0.171
H93.3 Disorders of acoustic nerve
0.170 0.830 0.000
H93.2 Other abnormal auditory perceptions
0.170 0.830 0.000
H93.0 Degenerative and vascular disorders of ear
0.170 0.830 0.000
I71.0 Dissection of aorta [any part]
0.000 0.831 0.168
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.834 0.166
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.001 0.836 0.163
I71.3 Abdominal aortic aneurysm, ruptured
0.001 0.836 0.163
I47 Paroxysmal tachycardia
0.000 0.837 0.162
I78.1 Naevus, nonneoplastic
0.001 0.838 0.162
I49 Other cardiac arrhythmias
0.000 0.838 0.162
H94.8 Other specified disorders of ear in diseases classified elsewhere
0.162 0.838 0.000
H94.0 Acoustic neuritis in infectious and parasitic diseases classified elsewhere
0.162 0.838 0.000
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.838 0.161
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.838 0.161
I97.0 Postcardiotomy syndrome
0.000 0.838 0.161
H93.9 Disorder of ear, unspecified
0.159 0.841 0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.843 0.157
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.843 0.157
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.843 0.157
I98.0 Cardiovascular syphilis
0.000 0.843 0.157
H60.4 Cholesteatoma of external ear
0.154 0.845 0.000
H62.8 Other disorders of external ear in diseases classified elsewhere
0.151 0.848 0.000
H62.4 Otitis externa in other diseases classified elsewhere
0.151 0.848 0.000
H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere
0.151 0.848 0.000
H62.2 Otitis externa in mycoses
0.151 0.848 0.000
H62.1 Otitis externa in viral diseases classified elsewhere
0.151 0.848 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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