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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77015620
log Bayes Factor = 18.4816
Chromosome 6   position 32,583,783  (GRCh37) Explore rs77015620 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.001 0.999
M06.9 Rheumatoid arthritis, unspecified
0.000 0.003 0.997
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.004 0.996
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.004 0.996
# Top node
0.036 0.005 0.959
E03 Other hypothyroidism
0.000 0.007 0.993
E00-E07 Disorders of thyroid gland
0.000 0.011 0.989
J45 Asthma
0.000 0.014 0.985
K90 Intestinal malabsorption
0.000 0.015 0.984
K90-K93 Other diseases of the digestive system
0.000 0.022 0.978
J40-J47 Chronic lower respiratory diseases
0.001 0.023 0.975
Chapter IV Endocrine, nutritional and metabolic diseases
0.004 0.026 0.969
Chapter XI Diseases of the digestive system
0.000 0.027 0.973
Chapter X Diseases of the respiratory system
0.008 0.027 0.964
K20-K31 Diseases of oesophagus, stomach and duodenum
0.000 0.036 0.964
Chapter II Neoplasms
0.000 0.044 0.956
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.003 0.049 0.949
C43-C44 Melanoma and other malignant neoplasms of skin
0.000 0.049 0.951
C44 Other malignant neoplasms of skin
0.000 0.049 0.951
K29 Gastritis and duodenitis
0.000 0.050 0.950
K29.8 Duodenitis
0.000 0.055 0.945
C44.3 Skin of other and unspecified parts of face
0.000 0.057 0.943
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.064 0.936
J44 Other chronic obstructive pulmonary disease
0.000 0.072 0.928
D60-D64 Aplastic and other anaemias
0.001 0.072 0.927
K20 Oesophagitis
0.000 0.072 0.928
C44.7 Skin of lower limb, including hip
0.000 0.082 0.918
D64 Other anaemias
0.000 0.085 0.915
M06 Other rheumatoid arthritis
0.028 0.089 0.884
J00-J06 Acute upper respiratory infections
0.002 0.090 0.909
D64.9 Anaemia, unspecified
0.000 0.094 0.906
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.000 0.096 0.904
E05.9 Thyrotoxicosis, unspecified
0.000 0.114 0.886
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.124 0.876
J46 Status asthmaticus
0.001 0.134 0.865
J20-J22 Other acute lower respiratory infections
0.004 0.136 0.861
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.136 0.864
K22 Other diseases of oesophagus
0.000 0.139 0.861
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.001 0.142 0.857
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.224 0.144 0.632
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.000 0.145 0.855
K29.4 Chronic atrophic gastritis
0.000 0.150 0.850
J02 Acute pharyngitis
0.001 0.154 0.845
D37-D48 Neoplasms of uncertain or unknown behaviour
0.000 0.156 0.844
J44.8 Other specified chronic obstructive pulmonary disease
0.000 0.158 0.842
M05-M14 Inflammatory polyarthropathies
0.138 0.164 0.698
D00-D09 In situ neoplasms
0.000 0.167 0.833
C44.0 Skin of lip
0.000 0.173 0.827
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.000 0.173 0.827
K70-K77 Diseases of liver
0.000 0.175 0.825
E10-E14 Diabetes mellitus
0.001 0.179 0.820
E06 Thyroiditis
0.000 0.182 0.818
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.000 0.182 0.818
K92 Other diseases of digestive system
0.000 0.184 0.816
K22.2 Oesophageal obstruction
0.000 0.189 0.811
Chapter XII Diseases of the skin and subcutaneous tissue
0.003 0.192 0.805
C51-C58 Malignant neoplasms of female genital organs
0.000 0.196 0.804
D06 Carcinoma in situ of cervix uteri
0.000 0.197 0.803
E50-E64 Other nutritional deficiencies
0.002 0.200 0.798
J02.9 Acute pharyngitis, unspecified
0.000 0.200 0.799
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.000 0.204 0.796
J22 Unspecified acute lower respiratory infection
0.000 0.205 0.795
K22.1 Ulcer of oesophagus
0.000 0.209 0.791
D06.9 Cervix, unspecified
0.000 0.219 0.781
D69 Purpura and other haemorrhagic conditions
0.001 0.220 0.780
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.000 0.221 0.779
E11 Non-insulin-dependent diabetes mellitus
0.000 0.226 0.774
M06.0 Seronegative rheumatoid arthritis
0.015 0.229 0.756
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.231 0.769
K92.0 Haematemesis
0.000 0.231 0.769
M80-M85 Disorders of bone density and structure
0.180 0.234 0.586
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.002 0.234 0.764
K70 Alcoholic liver disease
0.000 0.236 0.764
D45 Polycythaemia vera
0.000 0.242 0.758
E11.3 With ophthalmic complications
0.000 0.242 0.758
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.000 0.244 0.756
K26 Duodenal ulcer
0.000 0.245 0.755
D80-D89 Certain disorders involving the immune mechanism
0.002 0.252 0.746
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.253 0.747
K50-K52 Noninfective enteritis and colitis
0.013 0.254 0.734
J44.9 Chronic obstructive pulmonary disease, unspecified
0.000 0.254 0.746
D69.6 Thrombocytopenia, unspecified
0.000 0.262 0.738
L57 Skin changes due to chronic exposure to nonionising radiation
0.001 0.264 0.735
C73 Malignant neoplasm of thyroid gland
0.000 0.266 0.734
L40-L45 Papulosquamous disorders
0.001 0.266 0.733
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.269 0.731
K35-K38 Diseases of appendix
0.000 0.269 0.730
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.278 0.722
L57.0 Actinic keratosis
0.000 0.278 0.722
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.000 0.282 0.718
K27 Peptic ulcer, site unspecified
0.000 0.282 0.718
Chapter I Certain infectious and parasitic diseases
0.003 0.283 0.714
D62 Acute posthaemorrhagic anaemia
0.001 0.284 0.715
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.285 0.715
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.285 0.715
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.285 0.715
Chapter XVI Certain conditions originating in the perinatal period
0.026 0.286 0.688
K29.5 Chronic gastritis, unspecified
0.000 0.286 0.714
K51 Ulcerative colitis
0.004 0.288 0.708
E03.5 Myxoedema coma
0.000 0.288 0.712
E03.4 Atrophy of thyroid (acquired)
0.000 0.288 0.712
E03.3 Postinfectious hypothyroidism
0.000 0.288 0.712
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.288 0.712
E03.1 Congenital hypothyroidism without goitre
0.000 0.288 0.712
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.288 0.712
K29.1 Other acute gastritis
0.000 0.288 0.712
C53 Malignant neoplasm of cervix uteri
0.000 0.289 0.711
K70.9 Alcoholic liver disease, unspecified
0.000 0.289 0.711
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.291 0.709
E00 Congenital iodine-deficiency syndrome
0.000 0.291 0.709
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.291 0.709
J45.8 Mixed asthma
0.000 0.293 0.706
J45.1 Nonallergic asthma
0.000 0.293 0.706
K90.8 Other intestinal malabsorption
0.000 0.294 0.706
K90.3 Pancreatic steatorrhoea
0.000 0.294 0.706
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.294 0.706
K90.1 Tropical sprue
0.000 0.294 0.706
K22.9 Disease of oesophagus, unspecified
0.000 0.295 0.705
D70-D77 Other diseases of blood and blood-forming organs
0.001 0.297 0.702
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.299 0.701
J41 Simple and mucopurulent chronic bronchitis
0.001 0.300 0.699
E55 Vitamin D deficiency
0.001 0.300 0.699
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.000 0.304 0.695
C44.4 Skin of scalp and neck
0.000 0.305 0.695
E06.3 Autoimmune thyroiditis
0.000 0.305 0.695
C81 Hodgkin's disease
0.000 0.305 0.695
J45.0 Predominantly allergic asthma
0.000 0.306 0.694
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.006 0.307 0.687
C44.9 Malignant neoplasm of skin, unspecified
0.000 0.308 0.692
J01 Acute sinusitis
0.001 0.308 0.691
Chapter XXII Codes for special purposes
0.024 0.308 0.667
K28 Gastrojejunal ulcer
0.000 0.309 0.691
K23 Disorders of oesophagus in diseases classified elsewhere
0.000 0.309 0.691
J03 Acute tonsillitis
0.001 0.310 0.689
C54 Malignant neoplasm of corpus uteri
0.000 0.310 0.690
L40 Psoriasis
0.000 0.311 0.688
B35-B49 Mycoses
0.001 0.313 0.685
C40-C41 Malignant neoplasms of bone and articular cartilage
0.000 0.315 0.685
C60-C63 Malignant neoplasms of male genital organs
0.000 0.315 0.685
C64-C68 Malignant neoplasms of urinary tract
0.000 0.318 0.682
C44.8 Overlapping lesion of skin
0.000 0.318 0.681
K29.9 Gastroduodenitis, unspecified
0.000 0.319 0.681
K29.2 Alcoholic gastritis
0.000 0.319 0.681
D55-D59 Haemolytic anaemias
0.002 0.321 0.677
E07 Other disorders of thyroid
0.000 0.322 0.678
K51.9 Ulcerative colitis, unspecified
0.000 0.324 0.676
K31 Other diseases of stomach and duodenum
0.000 0.326 0.674
C92 Myeloid leukaemia
0.000 0.327 0.673
E20-E35 Disorders of other endocrine glands
0.003 0.327 0.670
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.007 0.329 0.665
E05.8 Other thyrotoxicosis
0.000 0.329 0.671
E05.5 Thyroid crisis or storm
0.000 0.329 0.671
E05.4 Thyrotoxicosis factitia
0.000 0.329 0.671
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.329 0.671
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.329 0.671
J95-J99 Other diseases of the respiratory system
0.005 0.329 0.666
D63 Anaemia in chronic diseases classified elsewhere
0.001 0.329 0.670
M81 Osteoporosis without pathological fracture
0.095 0.330 0.575
J00 Acute nasopharyngitis [common cold]
0.001 0.331 0.668
K92.1 Melaena
0.000 0.333 0.667
B37 Candidiasis
0.000 0.334 0.666
M05 Seropositive rheumatoid arthritis
0.080 0.334 0.586
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.001 0.334 0.665
C44.1 Skin of eyelid, including canthus
0.000 0.335 0.665
J04 Acute laryngitis and tracheitis
0.001 0.335 0.663
K29.3 Chronic superficial gastritis
0.000 0.336 0.664
E03.8 Other specified hypothyroidism
0.000 0.339 0.661
E11.4 With neurological complications
0.000 0.340 0.659
J06 Acute upper respiratory infections of multiple and unspecified sites
0.001 0.342 0.657
D64.8 Other specified anaemias
0.000 0.344 0.656
D64.4 Congenital dyserythropoietic anaemia
0.000 0.344 0.656
D64.3 Other sideroblastic anaemias
0.000 0.344 0.656
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.344 0.656
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.344 0.656
D64.0 Hereditary sideroblastic anaemia
0.000 0.344 0.656
M06.8 Other specified rheumatoid arthritis
0.020 0.346 0.633
M06.4 Inflammatory polyarthropathy
0.020 0.346 0.633
M06.3 Rheumatoid nodule
0.020 0.346 0.633
M06.2 Rheumatoid bursitis
0.020 0.346 0.633
M06.1 Adult-onset Still's disease
0.020 0.346 0.633
J05 Acute obstructive laryngitis [croup] and epiglottitis
0.001 0.347 0.651
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.348 0.651
D68 Other coagulation defects
0.001 0.350 0.650
K51.2 Ulcerative (chronic) proctitis
0.001 0.350 0.648
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.000 0.352 0.648
C95 Leukaemia of unspecified cell type
0.000 0.352 0.648
C94 Other leukaemias of specified cell type
0.000 0.352 0.648
C93 Monocytic leukaemia
0.000 0.352 0.648
C86 Other specified types of T/NK-cell lymphoma
0.000 0.352 0.648
C84 Peripheral and cutaneous T-cell lymphomas
0.000 0.352 0.648
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.352 0.648
C09 Malignant neoplasm of tonsil
0.000 0.352 0.648
K65-K67 Diseases of peritoneum
0.000 0.352 0.647
C53.9 Cervix uteri, unspecified
0.000 0.356 0.644
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.356 0.643
K26.9 Unspecified as acute or chronic, without haemorrhage or perforation
0.000 0.357 0.643
C90 Multiple myeloma and malignant plasma cell neoplasms
0.000 0.358 0.642
L40.9 Psoriasis, unspecified
0.000 0.358 0.642
C83 Diffuse non-Hodgkin's lymphoma
0.000 0.364 0.636
K90.9 Intestinal malabsorption, unspecified
0.000 0.364 0.636
B37.8 Candidiasis of other sites
0.000 0.364 0.636
E04 Other non-toxic goitre
0.000 0.367 0.633
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.003 0.369 0.628
C44.2 Skin of ear and external auricular canal
0.000 0.369 0.631
K72 Hepatic failure, not elsewhere classified
0.000 0.370 0.630
E55.9 Vitamin D deficiency, unspecified
0.000 0.372 0.628
K51.8 Other ulcerative colitis
0.002 0.373 0.626
D86 Sarcoidosis
0.001 0.373 0.627
C85.1 B-cell lymphoma, unspecified
0.000 0.373 0.627
C91 Lymphoid leukaemia
0.000 0.378 0.622
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.000 0.378 0.622
D46 Myelodysplastic syndromes
0.000 0.378 0.622
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.000 0.379 0.621
J21 Acute bronchiolitis
0.003 0.380 0.617
D47.2 Monoclonal gammopathy
0.000 0.380 0.620
K22.3 Perforation of oesophagus
0.000 0.382 0.618
K22.4 Dyskinesia of oesophagus
0.000 0.384 0.615
D67 Hereditary factor IX deficiency
0.001 0.385 0.614
D66 Hereditary factor VIII deficiency
0.001 0.385 0.614
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.001 0.385 0.614
M91-M94 Chondropathies
0.151 0.390 0.459
C88 Malignant immunoproliferative diseases
0.000 0.390 0.610
C54.1 Endometrium
0.000 0.391 0.609
J02.8 Acute pharyngitis due to other specified organisms
0.001 0.394 0.606
J02.0 Streptococcal pharyngitis
0.001 0.394 0.606
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.002 0.394 0.603
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.000 0.395 0.605
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.000 0.395 0.605
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.000 0.395 0.605
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.000 0.395 0.605
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.000 0.395 0.605
M81.9 Osteoporosis, unspecified
0.032 0.398 0.570
M14 Arthropathies in other diseases classified elsewhere
0.099 0.401 0.500
M12 Other specific arthropathies
0.099 0.401 0.500
M09 Juvenile arthritis in diseases classified elsewhere
0.099 0.401 0.500
M08 Juvenile arthritis
0.099 0.401 0.500
M07 Psoriatic and enteropathic arthropathies
0.091 0.401 0.508
A50-A64 Infections with a predominantly sexual mode of transmission
0.002 0.401 0.596
M00-M03 Infectious arthropathies
0.167 0.401 0.431
D02 Carcinoma in situ of middle ear and respiratory system
0.000 0.403 0.597
D01 Carcinoma in situ of other and unspecified digestive organs
0.000 0.403 0.597
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.000 0.403 0.597
D75 Other diseases of blood and blood-forming organs
0.000 0.403 0.596
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.000 0.404 0.595
C67 Malignant neoplasm of bladder
0.000 0.406 0.594
D47.3 Essential (haemorrhagic) thrombocythaemia
0.000 0.406 0.594
C75 Malignant neoplasm of other endocrine glands and related structures
0.000 0.407 0.593
C74 Malignant neoplasm of adrenal gland
0.000 0.407 0.593
M60-M63 Disorders of muscles
0.171 0.407 0.421
E11.5 With peripheral circulatory complications
0.000 0.408 0.592
K77 Liver disorders in diseases classified elsewhere
0.000 0.408 0.592
K73 Chronic hepatitis, not elsewhere classified
0.000 0.408 0.592
K71 Toxic liver disease
0.000 0.408 0.592
D07 Carcinoma in situ of other and unspecified genital organs
0.000 0.410 0.590
J90-J94 Other diseases of pleura
0.003 0.410 0.586
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.000 0.411 0.589
E12 Malnutrition-related diabetes mellitus
0.001 0.411 0.588
J20 Acute bronchitis
0.003 0.412 0.585
E06.9 Thyroiditis, unspecified
0.000 0.413 0.586
E06.5 Other chronic thyroiditis
0.000 0.413 0.586
E06.4 Drug-induced thyroiditis
0.000 0.413 0.586
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.413 0.586
E06.1 Subacute thyroiditis
0.000 0.413 0.586
E06.0 Acute thyroiditis
0.000 0.413 0.586
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.000 0.414 0.586
C82.6 Cutaneous follicle centre lymphoma
0.000 0.414 0.586
C82.5 Diffuse follicle centre lymphoma
0.000 0.414 0.586
C82.4 Follicular lymphoma grade IIIb
0.000 0.414 0.586
C82.3 Follicular lymphoma grade IIIa
0.000 0.414 0.586
C82.2 Large cell, follicular
0.000 0.414 0.586
C82.1 Mixed small cleaved and large cell, follicular
0.000 0.414 0.586
C82.0 Small cleaved cell, follicular
0.000 0.414 0.586
D68.9 Coagulation defect, unspecified
0.000 0.415 0.585
K92.8 Other specified diseases of digestive system
0.000 0.415 0.585
C02 Malignant neoplasm of other and unspecified parts of tongue
0.000 0.415 0.584
E53 Deficiency of other B group vitamins
0.001 0.417 0.582
D05 Carcinoma in situ of breast
0.000 0.417 0.583
C51 Malignant neoplasm of vulva
0.000 0.419 0.581
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.000 0.420 0.580
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.001 0.421 0.578
L10-L14 Bullous disorders
0.002 0.421 0.577
K70.4 Alcoholic hepatic failure
0.000 0.421 0.579
C44.5 Skin of trunk
0.000 0.422 0.578
J95 Postprocedural respiratory disorders, not elsewhere classified
0.003 0.423 0.575
K29.0 Acute haemorrhagic gastritis
0.000 0.423 0.577
C57 Malignant neoplasm of other and unspecified female genital organs
0.000 0.423 0.577
C58 Malignant neoplasm of placenta
0.000 0.423 0.577
C55 Malignant neoplasm of uterus, part unspecified
0.000 0.423 0.577
C52 Malignant neoplasm of vagina
0.000 0.423 0.577
D06.7 Other parts of cervix
0.000 0.424 0.575
D06.1 Exocervix
0.000 0.424 0.575
D06.0 Endocervix
0.000 0.424 0.575
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.426 0.574
K70.3 Alcoholic cirrhosis of liver
0.000 0.426 0.574
K26.4 Chronic or unspecified with haemorrhage
0.000 0.426 0.574
E64 Sequelae of malnutrition and other nutritional deficiencies
0.002 0.426 0.572
E63 Other nutritional deficiencies
0.002 0.426 0.572
E56 Other vitamin deficiencies
0.002 0.426 0.572
E51 Thiamine deficiency
0.002 0.426 0.572
E50 Vitamin A deficiency
0.002 0.426 0.572
E60 Dietary zinc deficiency
0.002 0.426 0.572
E59 Dietary selenium deficiency
0.002 0.426 0.572
E58 Dietary calcium deficiency
0.002 0.426 0.572
E54 Ascorbic acid deficiency
0.002 0.426 0.572
E52 Niacin deficiency [pellagra]
0.002 0.426 0.572
K22.8 Other specified diseases of oesophagus
0.000 0.428 0.572
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.000 0.429 0.570
C85.0 Lymphosarcoma
0.000 0.429 0.570
M11 Other crystal arthropathies
0.099 0.430 0.471
M81.99 Osteoporosis, unspecified (Site unspecified)
0.001 0.430 0.569
E40-E46 Malnutrition
0.004 0.432 0.564
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.000 0.433 0.567
K37 Unspecified appendicitis
0.000 0.437 0.563
J60-J70 Lung diseases due to external agents
0.006 0.438 0.556
B07 Viral warts
0.001 0.439 0.561
B37.0 Candidal stomatitis
0.000 0.439 0.561
E11.6 With other specified complications
0.000 0.440 0.560
D69.9 Haemorrhagic condition, unspecified
0.001 0.440 0.559
D69.8 Other specified haemorrhagic conditions
0.001 0.440 0.559
D69.4 Other primary thrombocytopenia
0.001 0.440 0.559
D69.2 Other nonthrombocytopenic purpura
0.001 0.440 0.559
D69.1 Qualitative platelet defects
0.001 0.440 0.559
D69.0 Allergic purpura
0.001 0.440 0.559
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.441 0.559
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.000 0.442 0.558
C13 Malignant neoplasm of hypopharynx
0.000 0.442 0.558
C11 Malignant neoplasm of nasopharynx
0.000 0.442 0.558
C10 Malignant neoplasm of oropharynx
0.000 0.442 0.558
C08 Malignant neoplasm of other and unspecified major salivary glands
0.000 0.442 0.558
C06 Malignant neoplasm of other and unspecified parts of mouth
0.000 0.442 0.558
C05 Malignant neoplasm of palate
0.000 0.442 0.558
C04 Malignant neoplasm of floor of mouth
0.000 0.442 0.558
C03 Malignant neoplasm of gum
0.000 0.442 0.558
C00 Malignant neoplasm of lip
0.000 0.442 0.558
C12 Malignant neoplasm of pyriform sinus
0.000 0.442 0.558
C07 Malignant neoplasm of parotid gland
0.000 0.442 0.558
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.164 0.443 0.393
K22.0 Achalasia of cardia
0.000 0.444 0.556
E11.8 With unspecified complications
0.000 0.445 0.555
E11.7 With multiple complications
0.000 0.445 0.555
K75 Other inflammatory liver diseases
0.000 0.445 0.555
C09.9 Tonsil, unspecified
0.000 0.446 0.554
D09 Carcinoma in situ of other and unspecified sites
0.000 0.447 0.552
M06.08 Seronegative rheumatoid arthritis (Other)
0.011 0.447 0.542
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.011 0.447 0.542
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.011 0.447 0.542
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.011 0.447 0.542
M06.04 Seronegative rheumatoid arthritis (Hand)
0.011 0.447 0.542
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.011 0.447 0.542
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.011 0.447 0.542
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.011 0.447 0.542
L40.5 Arthropathic psoriasis
0.000 0.448 0.552
D50-D53 Nutritional anaemias
0.001 0.449 0.550
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.010 0.449 0.541
M83 Adult osteomalacia
0.129 0.451 0.420
M82 Osteoporosis in diseases classified elsewhere
0.129 0.451 0.420
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.001 0.451 0.548
L58 Radiodermatitis
0.001 0.451 0.548
L56 Other acute skin changes due to ultraviolet radiation
0.001 0.451 0.548
L55 Sunburn
0.001 0.451 0.548
E13 Other specified diabetes mellitus
0.001 0.451 0.548
K70.2 Alcoholic fibrosis and sclerosis of liver
0.000 0.452 0.548
K70.0 Alcoholic fatty liver
0.000 0.452 0.548
C67.9 Bladder, unspecified
0.000 0.453 0.547
B90-B94 Sequelae of infectious and parasitic diseases
0.002 0.453 0.544
C81.9 Hodgkin's disease, unspecified
0.000 0.455 0.545
M05.9 Seropositive rheumatoid arthritis, unspecified
0.039 0.456 0.505
K27.9 Unspecified as acute or chronic, without haemorrhage or perforation
0.000 0.458 0.541
K26.6 Chronic or unspecified with both haemorrhage and perforation
0.000 0.459 0.541
K26.2 Acute with both haemorrhage and perforation
0.000 0.459 0.541
K26.1 Acute with perforation
0.000 0.459 0.541
K26.0 Acute with haemorrhage
0.000 0.459 0.541
M40-M43 Deforming dorsopathies
0.153 0.460 0.387
C92.0 Acute myeloid leukaemia
0.000 0.460 0.540
K76 Other diseases of liver
0.000 0.460 0.540
E29 Testicular dysfunction
0.002 0.462 0.536
D84 Other immunodeficiencies
0.001 0.464 0.535
D83 Common variable immunodeficiency
0.001 0.464 0.535
D82 Immunodeficiency associated with other major defects
0.001 0.464 0.535
D81 Combined immunodeficiencies
0.001 0.464 0.535
C01 Malignant neoplasm of base of tongue
0.000 0.464 0.536
J01.9 Acute sinusitis, unspecified
0.001 0.465 0.534
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.465 0.535
J03.9 Acute tonsillitis, unspecified
0.001 0.467 0.532
E11.0 With coma
0.000 0.467 0.532
K70.1 Alcoholic hepatitis
0.000 0.468 0.532
K22.5 Diverticulum of oesophagus, acquired
0.000 0.468 0.532
D75.1 Secondary polycythaemia
0.000 0.469 0.531
K35 Acute appendicitis
0.000 0.469 0.531
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.001 0.472 0.527
L57.5 Actinic granuloma
0.001 0.472 0.527
L57.4 Cutis laxa senilis
0.001 0.472 0.527
L57.3 Poikiloderma of Civatte
0.001 0.472 0.527
L57.2 Cutis rhomboidalis nuchae
0.001 0.472 0.527
L57.1 Actinic reticuloid
0.001 0.472 0.527
C61 Malignant neoplasm of prostate
0.000 0.473 0.527
D80 Immunodeficiency with predominantly antibody defects
0.001 0.473 0.526
L44 Other papulosquamous disorders
0.001 0.474 0.525
L41 Parapsoriasis
0.001 0.474 0.525
L45 Papulosquamous disorders in diseases classified elsewhere
0.001 0.474 0.525
L42 Pityriasis rosea
0.001 0.474 0.525
K31.8 Other specified diseases of stomach and duodenum
0.000 0.474 0.526
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
0.000 0.476 0.524
D47.7 Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.000 0.476 0.524
D47.5 Chronic eosinophilic leukaemia [hypereosinophilic syndrome]
0.000 0.476 0.524
D47.4 Osteomyelofibrosis
0.000 0.476 0.524
D47.0 Histiocytic and mast cell tumours of uncertain and unknown behaviour
0.000 0.476 0.524
K26.7 Chronic without haemorrhage or perforation
0.000 0.476 0.524
K36 Other appendicitis
0.000 0.476 0.524
D61 Other aplastic anaemias
0.001 0.476 0.522
D48.5 Skin
0.000 0.477 0.523
D86.0 Sarcoidosis of lung
0.000 0.479 0.520
M80 Osteoporosis with pathological fracture
0.126 0.481 0.394
L82 Seborrhoeic keratosis
0.000 0.481 0.519
B20-B24 Human immunodeficiency virus [HIV] disease
0.003 0.481 0.516
B35 Dermatophytosis
0.001 0.483 0.516
E21.0 Primary hyperparathyroidism
0.000 0.484 0.515
K27.7 Chronic without haemorrhage or perforation
0.000 0.485 0.515
K27.6 Chronic or unspecified with both haemorrhage and perforation
0.000 0.485 0.515
K27.5 Chronic or unspecified with perforation
0.000 0.485 0.515
K27.4 Chronic or unspecified with haemorrhage
0.000 0.485 0.515
K27.3 Acute without haemorrhage or perforation
0.000 0.485 0.515
K27.2 Acute with both haemorrhage and perforation
0.000 0.485 0.515
K27.1 Acute with perforation
0.000 0.485 0.515
K27.0 Acute with haemorrhage
0.000 0.485 0.515
M86-M90 Other osteopathies
0.204 0.486 0.310
B99-B99 Other infectious diseases
0.003 0.486 0.512
B85-B89 Pediculosis, acariasis and other infestations
0.003 0.486 0.512
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.003 0.486 0.512
A75-A79 Rickettsioses
0.003 0.486 0.512
A70-A74 Other diseases caused by chlamydiae
0.003 0.486 0.512
A65-A69 Other spirochaetal diseases
0.003 0.486 0.512
A20-A28 Certain zoonotic bacterial diseases
0.003 0.486 0.512
A15-A19 Tuberculosis
0.003 0.486 0.512
K26.5 Chronic or unspecified with perforation
0.000 0.486 0.514
C50-C50 Malignant neoplasm of breast
0.000 0.486 0.514
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.001 0.486 0.513
K31.1 Adult hypertrophic pyloric stenosis
0.000 0.487 0.512
M85 Other disorders of bone density and structure
0.131 0.488 0.382
P90-P96 Other disorders originating in the perinatal period
0.019 0.488 0.493
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn
0.019 0.488 0.493
P75-P78 Digestive system disorders of fetus and newborn
0.019 0.488 0.493
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn
0.019 0.488 0.493
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn
0.019 0.488 0.493
P35-P39 Infections specific to the perinatal period
0.019 0.488 0.493
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period
0.019 0.488 0.493
P10-P15 Birth trauma
0.019 0.488 0.493
P05-P08 Disorders related to length of gestation and fetal growth
0.019 0.488 0.493
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery
0.019 0.488 0.493
D04 Carcinoma in situ of skin
0.000 0.489 0.511
K51.1 Ulcerative (chronic) ileocolitis
0.003 0.489 0.508
J95.8 Other postprocedural respiratory disorders
0.001 0.490 0.509
Z85.8 Personal history of malignant neoplasms of other organs and systems
0.000 0.490 0.510
C53.8 Overlapping lesion of cervix uteri
0.000 0.490 0.510
C53.1 Exocervix
0.000 0.490 0.510
C53.0 Endocervix
0.000 0.490 0.510
C97 Malignant neoplasms of independent (primary) multiple sites
0.000 0.491 0.509
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.491 0.508
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.491 0.508
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.491 0.508
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.491 0.508
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.491 0.508
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.491 0.508
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.491 0.508
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.491 0.508
B25-B34 Other viral diseases
0.002 0.491 0.507
K38 Other diseases of appendix
0.000 0.492 0.508
E61 Deficiency of other nutrient elements
0.002 0.494 0.504
D86.9 Sarcoidosis, unspecified
0.000 0.494 0.505
M10 Gout
0.084 0.496 0.420
D72 Other disorders of white blood cells
0.001 0.496 0.504
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.001 0.496 0.503
D74 Methaemoglobinaemia
0.001 0.496 0.503
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.001 0.496 0.503
D71 Functional disorders of polymorphonuclear neutrophils
0.001 0.496 0.503
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.497 0.503
K93.1 Megacolon in Chagas' disease
0.000 0.497 0.503
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.497 0.503
C90.0 Multiple myeloma
0.000 0.497 0.503
J41.8 Mixed simple and mucopurulent chronic bronchitis
0.001 0.498 0.501
J41.1 Mucopurulent chronic bronchitis
0.001 0.498 0.501
J41.0 Simple chronic bronchitis
0.001 0.498 0.501
D47.1 Chronic myeloproliferative disease
0.000 0.498 0.502
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.001 0.498 0.501
E55.0 Rickets, active
0.001 0.498 0.501
D63.0 Anaemia in neoplastic disease
0.000 0.498 0.501
L40.0 Psoriasis vulgaris
0.000 0.499 0.501
E04.9 Non-toxic goitre, unspecified
0.000 0.499 0.501
C44.6 Skin of upper limb, including shoulder
0.000 0.500 0.499
B37.9 Candidiasis, unspecified
0.000 0.501 0.499
C83.3 Large cell (diffuse)
0.000 0.501 0.499
E07.9 Disorder of thyroid, unspecified
0.000 0.501 0.498
C81.7 Other Hodgkin's disease
0.000 0.502 0.498
C81.4 Lymphocyte-rich classical Hodgkin lymphoma
0.000 0.502 0.498
C81.3 Lymphocytic depletion
0.000 0.502 0.498
C81.2 Mixed cellularity
0.000 0.502 0.498
C81.1 Nodular sclerosis
0.000 0.502 0.498
C81.0 Lymphocytic predominance
0.000 0.502 0.498

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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