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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77172747
log Bayes Factor = 11.7522
Chromosome 16   position 67,605,125  (GRCh37) Explore rs77172747 on Ensembl!
Variant rs77172747 is part of Cluster X0258

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
D10-D36 Benign neoplasms
1.000 0.000 0.000
M70-M79 Other soft tissue disorders
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
D25 Leiomyoma of uterus
0.999 0.001 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.998 0.002 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.997 0.003 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.996 0.004 0.000
N80 Endometriosis
0.992 0.008 0.000
D25.9 Leiomyoma of uterus, unspecified
0.988 0.012 0.000
N92 Excessive, frequent and irregular menstruation
0.987 0.013 0.000
M05-M14 Inflammatory polyarthropathies
0.986 0.014 0.000
N60-N64 Disorders of breast
0.984 0.016 0.000
M75 Shoulder lesions
0.982 0.018 0.000
E10-E14 Diabetes mellitus
0.981 0.019 0.000
N92.0 Excessive and frequent menstruation with regular cycle
0.981 0.019 0.000
E20-E35 Disorders of other endocrine glands
0.979 0.021 0.000
M79.6 Pain in limb
0.970 0.030 0.000
M06 Other rheumatoid arthritis
0.970 0.030 0.000
Chapter IX Diseases of the circulatory system
0.969 0.031 0.000
I10-I15 Hypertensive diseases
0.962 0.038 0.000
E10 Insulin-dependent diabetes mellitus
0.960 0.040 0.000
I10 Essential (primary) hypertension
0.960 0.040 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.948 0.052 0.000
D17 Benign lipomatous neoplasm
0.947 0.053 0.000
N80.1 Endometriosis of ovary
0.946 0.054 0.000
C15-C26 Malignant neoplasms of digestive organs
0.944 0.056 0.000
Chapter VI Diseases of the nervous system
0.944 0.056 0.000
D25.1 Intramural leiomyoma of uterus
0.943 0.057 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.942 0.058 0.000
E10.9 Without complications
0.940 0.060 0.000
D17.2 Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
0.934 0.066 0.000
N83 Noninflammatory disorders of ovary, Fallopian tube and broad ligament
0.928 0.072 0.000
M06.9 Rheumatoid arthritis, unspecified
0.927 0.073 0.000
G40-G47 Episodic and paroxysmal disorders
0.921 0.079 0.000
D00-D09 In situ neoplasms
0.917 0.083 0.000
E21.0 Primary hyperparathyroidism
0.915 0.085 0.000
G47 Sleep disorders
0.914 0.086 0.000
E65-E68 Obesity and other hyperalimentation
0.913 0.087 0.000
N10-N16 Renal tubulo-interstitial diseases
0.912 0.088 0.000
C20 Malignant neoplasm of rectum
0.908 0.092 0.000
D25.2 Subserosal leiomyoma of uterus
0.903 0.097 0.000
N00-N08 Glomerular diseases
0.901 0.099 0.000
N17-N19 Renal failure
0.900 0.100 0.000
D11 Benign neoplasm of major salivary glands
0.895 0.105 0.000
M79.7 Fibromyalgia
0.894 0.106 0.000
N80.0 Endometriosis of uterus
0.894 0.106 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.892 0.108 0.000
M65-M68 Disorders of synovium and tendon
0.891 0.109 0.000
D27 Benign neoplasm of ovary
0.886 0.114 0.000
N60 Benign mammary dysplasia
0.884 0.116 0.000
M15-M19 Arthrosis
0.881 0.119 0.000
N62 Hypertrophy of breast
0.880 0.120 0.000
M80-M85 Disorders of bone density and structure
0.879 0.121 0.000
M79.8 Other specified soft tissue disorders
0.878 0.122 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.878 0.122 0.000
M75.4 Impingement syndrome of shoulder
0.877 0.123 0.000
M06.0 Seronegative rheumatoid arthritis
0.875 0.125 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.874 0.126 0.000
N64 Other disorders of breast
0.873 0.127 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.872 0.128 0.000
M19 Other arthrosis
0.872 0.128 0.000
M19.9 Arthrosis, unspecified
0.869 0.131 0.000
G47.3 Sleep apnoea
0.869 0.131 0.000
N92.1 Excessive and frequent menstruation with irregular cycle
0.868 0.132 0.000
N18 Chronic renal failure
0.868 0.132 0.000
C50-C50 Malignant neoplasm of breast
0.862 0.138 0.000
D24 Benign neoplasm of breast
0.855 0.145 0.000
E66 Obesity
0.853 0.147 0.000
Chapter VII Diseases of the eye and adnexa
0.851 0.149 0.000
G47.9 Sleep disorder, unspecified
0.851 0.149 0.000
M10 Gout
0.850 0.150 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.847 0.153 0.000
N83.2 Other and unspecified ovarian cysts
0.846 0.154 0.000
M79.62 Pain in limb (Upper arm)
0.845 0.155 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.844 0.156 0.000
D10 Benign neoplasm of mouth and pharynx
0.843 0.157 0.000
N80.3 Endometriosis of pelvic peritoneum
0.842 0.158 0.000
D17.1 Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk
0.839 0.161 0.000
C16 Malignant neoplasm of stomach
0.838 0.162 0.000
M75.1 Rotator cuff syndrome
0.837 0.163 0.000
E27 Other disorders of adrenal gland
0.836 0.164 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.833 0.167 0.000
N99-N99 Other disorders of the genitourinary system
0.831 0.169 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.830 0.170 0.000
N61 Inflammatory disorders of breast
0.829 0.171 0.000
D35 Benign neoplasm of other and unspecified endocrine glands
0.828 0.171 0.000
E11 Non-insulin-dependent diabetes mellitus
0.827 0.173 0.000
M79.69 Pain in limb (Site unspecified)
0.827 0.173 0.000
M71 Other bursopathies
0.826 0.174 0.000
M75.3 Calcific tendinitis of shoulder
0.823 0.177 0.000
M79.79 Fibromyalgia (Site unspecified)
0.821 0.179 0.000
D11.0 Parotid gland
0.820 0.180 0.000
G70-G73 Diseases of myoneural junction and muscle
0.818 0.182 0.000
I05-I09 Chronic rheumatic heart diseases
0.818 0.182 0.000
E66.8 Other obesity
0.815 0.185 0.000
N18.3 Chronic kidney disease, stage 3
0.813 0.187 0.000
N80.4 Endometriosis of rectovaginal septum and vagina
0.813 0.187 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.808 0.192 0.000
M65 Synovitis and tenosynovitis
0.808 0.192 0.000
M07 Psoriatic and enteropathic arthropathies
0.808 0.192 0.000
Chapter XXII Codes for special purposes
0.805 0.195 0.000
M75.2 Bicipital tendinitis
0.801 0.199 0.000
C64-C68 Malignant neoplasms of urinary tract
0.800 0.200 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.800 0.200 0.000
E13 Other specified diabetes mellitus
0.800 0.200 0.000
E23 Hypofunction and other disorders of pituitary gland
0.799 0.201 0.000
N64.8 Other specified disorders of breast
0.797 0.203 0.000
Q60-Q64 Congenital malformations of the urinary system
0.796 0.204 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.796 0.204 0.000
D31 Benign neoplasm of eye and adnexa
0.795 0.205 0.000
M40-M43 Deforming dorsopathies
0.789 0.211 0.000
M79.67 Pain in limb (Ankle and foot)
0.789 0.211 0.000
M79.0 Rheumatism, unspecified
0.788 0.212 0.000
D06 Carcinoma in situ of cervix uteri
0.787 0.213 0.000
D30 Benign neoplasm of urinary organs
0.787 0.213 0.000
E10.2 With renal complications
0.786 0.214 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.786 0.214 0.000
N94.8 Other specified conditions associated with female genital organs and menstrual cycle
0.786 0.214 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.785 0.215 0.000
N80.8 Other endometriosis
0.784 0.216 0.000
H40-H42 Glaucoma
0.782 0.218 0.000
D28 Benign neoplasm of other and unspecified female genital organs
0.780 0.220 0.000
N80.2 Endometriosis of Fallopian tube
0.777 0.223 0.000
M79.5 Residual foreign body in soft tissue
0.776 0.224 0.000
D04 Carcinoma in situ of skin
0.775 0.225 0.000
M50-M54 Other dorsopathies
0.773 0.227 0.000
M79.66 Pain in limb (Lower leg)
0.772 0.228 0.000
N60.1 Diffuse cystic mastopathy
0.769 0.231 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.769 0.231 0.000
O60-O75 Complications of labour and delivery
0.767 0.233 0.000
M72 Fibroblastic disorders
0.767 0.233 0.000
C51-C58 Malignant neoplasms of female genital organs
0.767 0.233 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.766 0.234 0.000
E21.3 Hyperparathyroidism, unspecified
0.766 0.234 0.000
M45-M49 Spondylopathies
0.765 0.235 0.000
M84 Disorders of continuity of bone
0.765 0.235 0.000
M75.9 Shoulder lesion, unspecified
0.763 0.237 0.000
C50 Malignant neoplasm of breast
0.763 0.237 0.000
D17.5 Benign lipomatous neoplasm of intra-abdominal organs
0.761 0.239 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.760 0.240 0.000
N03 Chronic nephritic syndrome
0.760 0.240 0.000
I77 Other disorders of arteries and arterioles
0.756 0.244 0.000
M91-M94 Chondropathies
0.754 0.246 0.000
D03 Melanoma in situ
0.754 0.246 0.000
M06.4 Inflammatory polyarthropathy
0.754 0.246 0.000
M10.9 Gout, unspecified
0.752 0.248 0.000
M81 Osteoporosis without pathological fracture
0.750 0.249 0.000
M75.5 Bursitis of shoulder
0.749 0.251 0.000
Q50-Q56 Congenital malformations of genital organs
0.749 0.251 0.000
D22 Melanocytic naevi
0.748 0.252 0.000
M05 Seropositive rheumatoid arthritis
0.748 0.252 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.747 0.253 0.000
I71 Aortic aneurysm and dissection
0.747 0.253 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.744 0.256 0.000
N83.1 Corpus luteum cyst
0.743 0.257 0.000
M79.63 Pain in limb (Forearm)
0.743 0.257 0.000
D29 Benign neoplasm of male genital organs
0.743 0.257 0.000
Q00-Q07 Congenital malformations of the nervous system
0.742 0.258 0.000
N92.3 Ovulation bleeding
0.742 0.258 0.000
N18.5 Chronic kidney disease, stage 5
0.741 0.259 0.000
M79.88 Other specified soft tissue disorders (Other)
0.739 0.260 0.000
I11 Hypertensive heart disease
0.738 0.261 0.000
N60.2 Fibroadenosis of breast
0.737 0.263 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.737 0.263 0.000
G47.0 Disorders of initiating and maintaining sleep [insomnias]
0.737 0.263 0.000
D32 Benign neoplasm of meninges
0.735 0.265 0.000
D26 Other benign neoplasms of uterus
0.734 0.266 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.734 0.266 0.000
H40 Glaucoma
0.733 0.267 0.000
C17 Malignant neoplasm of small intestine
0.732 0.268 0.000
Q80-Q89 Other congenital malformations
0.729 0.271 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.729 0.271 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.728 0.272 0.000
G47.1 Disorders of excessive somnolence [hypersomnias]
0.726 0.274 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.725 0.275 0.000
E11.9 Without complications
0.724 0.276 0.000
N13 Obstructive and reflux uropathy
0.724 0.276 0.000
M77 Other enthesopathies
0.723 0.277 0.000
M79.64 Pain in limb (Hand)
0.723 0.277 0.000
M79.1 Myalgia
0.723 0.277 0.000
N80.9 Endometriosis, unspecified
0.722 0.278 0.000
E10.4 With neurological complications
0.721 0.279 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.721 0.279 0.000
M79.85 Other specified soft tissue disorders (Pelvic region and thigh)
0.720 0.280 0.000
D14 Benign neoplasm of middle ear and respiratory system
0.719 0.281 0.000
N04 Nephrotic syndrome
0.719 0.281 0.000
C16.9 Stomach, unspecified
0.718 0.282 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.718 0.282 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum
0.717 0.283 0.000
D19 Benign neoplasm of mesothelial tissue
0.717 0.283 0.000
D16 Benign neoplasm of bone and articular cartilage
0.717 0.283 0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs
0.717 0.283 0.000
M76 Enthesopathies of lower limb, excluding foot
0.717 0.283 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.717 0.283 0.000
C16.5 Lesser curvature of stomach, unspecified
0.716 0.284 0.000
M79.9 Soft tissue disorder, unspecified
0.715 0.285 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.715 0.285 0.000
M79.3 Panniculitis, unspecified
0.715 0.285 0.000
M79.2 Neuralgia and neuritis, unspecified
0.715 0.285 0.000
N98 Complications associated with artificial fertilisation
0.714 0.286 0.000
N91 Absent, scanty and rare menstruation
0.714 0.286 0.000
N82 Fistulae involving female genital tract
0.714 0.286 0.000
N96 Habitual aborter
0.714 0.286 0.000
H25-H28 Disorders of lens
0.714 0.286 0.000
N18.9 Chronic renal failure, unspecified
0.713 0.287 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.712 0.288 0.000
N94.9 Unspecified condition associated with female genital organs and menstrual cycle
0.712 0.288 0.000
D36 Benign neoplasm of other and unspecified sites
0.712 0.288 0.000
N80.6 Endometriosis in cutaneous scar
0.711 0.289 0.000
N80.5 Endometriosis of intestine
0.711 0.289 0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified
0.711 0.289 0.000
C15 Malignant neoplasm of oesophagus
0.710 0.290 0.000
C34 Malignant neoplasm of bronchus and lung
0.709 0.291 0.000
D41.4 Bladder
0.708 0.292 0.000
N92.5 Other specified irregular menstruation
0.708 0.292 0.000
N92.2 Excessive menstruation at puberty
0.708 0.292 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.707 0.293 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.707 0.293 0.000
M14 Arthropathies in other diseases classified elsewhere
0.707 0.293 0.000
M12 Other specific arthropathies
0.707 0.293 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.707 0.293 0.000
M08 Juvenile arthritis
0.707 0.293 0.000
I99 Other and unspecified disorders of circulatory system
0.707 0.293 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.707 0.293 0.000
M75.0 Adhesive capsulitis of shoulder
0.706 0.294 0.000
E10.3 With ophthalmic complications
0.706 0.294 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.704 0.296 0.000
N95 Menopausal and other perimenopausal disorders
0.704 0.296 0.000
M75.8 Other shoulder lesions
0.704 0.296 0.000
E12 Malnutrition-related diabetes mellitus
0.704 0.296 0.000
G51 Facial nerve disorders
0.703 0.297 0.000
M71.2 Synovial cyst of popliteal space [Baker]
0.702 0.298 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.702 0.298 0.000
E34 Other endocrine disorders
0.702 0.298 0.000
E32 Diseases of thymus
0.702 0.298 0.000
E31 Polyglandular dysfunction
0.702 0.298 0.000
E30 Disorders of puberty, not elsewhere classified
0.702 0.298 0.000
E26 Hyperaldosteronism
0.702 0.298 0.000
E25 Adrenogenital disorders
0.702 0.298 0.000
E24 Cushing's syndrome
0.702 0.298 0.000
E20 Hypoparathyroidism
0.702 0.298 0.000
D35.2 Pituitary gland
0.702 0.298 0.000
N94.6 Dysmenorrhoea, unspecified
0.701 0.299 0.000
N92.4 Excessive bleeding in the premenopausal period
0.700 0.299 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.700 0.300 0.000
N83.0 Follicular cyst of ovary
0.700 0.300 0.000
C21 Malignant neoplasm of anus and anal canal
0.699 0.301 0.000
E50-E64 Other nutritional deficiencies
0.697 0.303 0.000
M79.68 Pain in limb (Other)
0.695 0.304 0.000
M79.61 Pain in limb (Shoulder region)
0.695 0.304 0.000
M06.8 Other specified rheumatoid arthritis
0.695 0.305 0.000
M06.3 Rheumatoid nodule
0.695 0.305 0.000
M06.2 Rheumatoid bursitis
0.695 0.305 0.000
M06.1 Adult-onset Still's disease
0.695 0.305 0.000
I00-I02 Acute rheumatic fever
0.695 0.305 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.695 0.305 0.000
D06.9 Cervix, unspecified
0.695 0.305 0.000
D22.7 Melanocytic naevi of lower limb, including hip
0.695 0.305 0.000
D10.3 Other and unspecified parts of mouth
0.694 0.306 0.000
N64.9 Disorder of breast, unspecified
0.693 0.307 0.000
Chapter VIII Diseases of the ear and mastoid process
0.691 0.309 0.000
N90 Other noninflammatory disorders of vulva and perineum
0.691 0.309 0.000
N25-N29 Other disorders of kidney and ureter
0.691 0.309 0.000
M10.99 Gout, unspecified (Site unspecified)
0.691 0.309 0.000
M79.82 Other specified soft tissue disorders (Upper arm)
0.690 0.310 0.000
I15 Secondary hypertension
0.690 0.310 0.000
I13 Hypertensive heart and renal disease
0.690 0.310 0.000
E22 Hyperfunction of pituitary gland
0.690 0.310 0.000
E10.8 With unspecified complications
0.688 0.311 0.000
E10.7 With multiple complications
0.688 0.311 0.000
E10.6 With other specified complications
0.688 0.311 0.000
E10.5 With peripheral circulatory complications
0.688 0.311 0.000
E10.0 With coma
0.688 0.311 0.000
G44 Other headache syndromes
0.686 0.314 0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system
0.685 0.315 0.000
I05 Rheumatic mitral valve diseases
0.685 0.315 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.682 0.318 0.000
I74 Arterial embolism and thrombosis
0.682 0.318 0.000
M07.3 Other psoriatic arthropathies
0.681 0.319 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.681 0.319 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.680 0.320 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.679 0.320 0.000
E21.4 Other specified disorders of parathyroid gland
0.679 0.320 0.000
E21.2 Other hyperparathyroidism
0.679 0.320 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.679 0.320 0.000
D17.4 Benign lipomatous neoplasm of intrathoracic organs
0.679 0.321 0.000
D33 Benign neoplasm of brain and other parts of central nervous system
0.679 0.321 0.000
H02 Other disorders of eyelid
0.679 0.321 0.000
I78 Diseases of capillaries
0.678 0.322 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.677 0.323 0.000
C23 Malignant neoplasm of gallbladder
0.677 0.323 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.677 0.323 0.000
E40-E46 Malnutrition
0.676 0.324 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.675 0.325 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.675 0.325 0.000
Q35-Q37 Cleft lip and cleft palate
0.675 0.325 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.675 0.325 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.675 0.325 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.674 0.325 0.000
M65.3 Trigger finger
0.673 0.327 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.671 0.329 0.000
N83.8 Other noninflammatory disorders of ovary, Fallopian tube and broad ligament
0.670 0.330 0.000
E23.0 Hypopituitarism
0.670 0.330 0.000
I95 Hypotension
0.670 0.330 0.000
E13.9 Without complications
0.669 0.331 0.000
G43 Migraine
0.669 0.331 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.669 0.331 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.669 0.331 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.669 0.331 0.000
M48 Other spondylopathies
0.669 0.331 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.668 0.332 0.000
M43 Other deforming dorsopathies
0.668 0.332 0.000
G72 Other myopathies
0.668 0.332 0.000
G57 Mononeuropathies of lower limb
0.667 0.333 0.000
H26 Other cataract
0.667 0.333 0.000
E29 Testicular dysfunction
0.667 0.333 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.666 0.334 0.000
I70 Atherosclerosis
0.666 0.334 0.000
M54 Dorsalgia
0.665 0.335 0.000
N83.9 Noninflammatory disorder of ovary, Fallopian tube and broad ligament, unspecified
0.665 0.335 0.000
N83.7 Haematoma of broad ligament
0.665 0.335 0.000
N83.6 Haematosalpinx
0.665 0.335 0.000
N83.5 Torsion of ovary, ovarian pedicle and Fallopian tube
0.665 0.335 0.000
N83.4 Prolapse and hernia of ovary and Fallopian tube
0.665 0.335 0.000
N83.3 Acquired atrophy of ovary and Fallopian tube
0.665 0.335 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.664 0.336 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.664 0.336 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.664 0.336 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.664 0.336 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.664 0.336 0.000
M79.80 Other specified soft tissue disorders (Multiple sites)
0.664 0.336 0.000
H55-H59 Other disorders of eye and adnexa
0.664 0.336 0.000
D10.1 Tongue
0.662 0.338 0.000
G71 Primary disorders of muscles
0.661 0.338 0.000
E28 Ovarian dysfunction
0.661 0.339 0.000
N60.8 Other benign mammary dysplasias
0.660 0.340 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.660 0.340 0.000
G41 Status epilepticus
0.660 0.340 0.000
M86-M90 Other osteopathies
0.659 0.341 0.000
M11 Other crystal arthropathies
0.658 0.342 0.000
N03.9 Unspecified
0.658 0.342 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.657 0.343 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.657 0.343 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.657 0.343 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.657 0.343 0.000
E27.9 Disorder of adrenal gland, unspecified
0.657 0.343 0.000
D25.0 Submucous leiomyoma of uterus
0.656 0.344 0.000
G47.8 Other sleep disorders
0.655 0.345 0.000
G47.4 Narcolepsy and cataplexy
0.655 0.345 0.000
G47.2 Disorders of the sleep-wake schedule
0.655 0.345 0.000
E67 Other hyperalimentation
0.655 0.345 0.000
E68 Sequelae of hyperalimentation
0.655 0.345 0.000
E65 Localised adiposity
0.655 0.345 0.000
C50.4 Upper-outer quadrant of breast
0.655 0.345 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.655 0.345 0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere
0.654 0.346 0.000
N15 Other renal tubulo-interstitial diseases
0.654 0.346 0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
0.654 0.346 0.000
N11 Chronic tubulo-interstitial nephritis
0.654 0.346 0.000
N02 Recurrent and persistent haematuria
0.654 0.346 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.654 0.346 0.000
M67 Other disorders of synovium and tendon
0.654 0.346 0.000
M79.87 Other specified soft tissue disorders (Ankle and foot)
0.653 0.347 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.653 0.347 0.000
M81.9 Osteoporosis, unspecified
0.652 0.348 0.000
N89 Other noninflammatory disorders of vagina
0.652 0.348 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.649 0.351 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.649 0.351 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.649 0.351 0.000
D31.0 Conjunctiva
0.648 0.352 0.000
D03.3 Melanoma in situ of other and unspecified parts of face
0.646 0.354 0.000
N07 Hereditary nephropathy, not elsewhere classified
0.646 0.354 0.000
N06 Isolated proteinuria with specified morphological lesion
0.646 0.354 0.000
N01 Rapidly progressive nephritic syndrome
0.646 0.354 0.000
N00 Acute nephritic syndrome
0.646 0.354 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.645 0.354 0.000
I08 Multiple valve diseases
0.645 0.355 0.000
Q61 Cystic kidney disease
0.644 0.356 0.000
C66 Malignant neoplasm of ureter
0.644 0.356 0.000
N60.4 Mammary duct ectasia
0.644 0.356 0.000
C50.3 Lower-inner quadrant of breast
0.642 0.358 0.000
Q63 Other congenital malformations of kidney
0.642 0.358 0.000
D11.9 Major salivary gland, unspecified
0.642 0.358 0.000
D11.7 Other major salivary glands
0.642 0.358 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.642 0.358 0.000
M79.78 Fibromyalgia (Other)
0.641 0.359 0.000
M79.77 Fibromyalgia (Ankle and foot)
0.641 0.359 0.000
M79.76 Fibromyalgia (Lower leg)
0.641 0.359 0.000
M79.75 Fibromyalgia (Pelvic region and thigh)
0.641 0.359 0.000
M79.74 Fibromyalgia (Hand)
0.641 0.359 0.000
M79.73 Fibromyalgia (Forearm)
0.641 0.359 0.000
M79.72 Fibromyalgia (Upper arm)
0.641 0.359 0.000
M79.71 Fibromyalgia (Shoulder region)
0.641 0.359 0.000
M79.70 Fibromyalgia (Multiple sites)
0.641 0.359 0.000
D04.4 Skin of scalp and neck
0.641 0.359 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.641 0.359 0.000
E27.8 Other specified disorders of adrenal gland
0.641 0.359 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.640 0.360 0.000
N60.3 Fibrosclerosis of breast
0.640 0.360 0.000
E11.6 With other specified complications
0.640 0.360 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.640 0.360 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.640 0.360 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.640 0.360 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.640 0.360 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.639 0.361 0.000
M66 Spontaneous rupture of synovium and tendon
0.639 0.361 0.000
D35.1 Parathyroid gland
0.638 0.361 0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid
0.638 0.362 0.000
M79.09 Rheumatism, unspecified (Site unspecified)
0.638 0.362 0.000
M79.84 Other specified soft tissue disorders (Hand)
0.637 0.363 0.000
M65.4 Radial styloid tenosynovitis [de Quervain]
0.637 0.363 0.000
M54.2 Cervicalgia
0.636 0.364 0.000
D46 Myelodysplastic syndromes
0.636 0.364 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.635 0.364 0.000
D09 Carcinoma in situ of other and unspecified sites
0.635 0.365 0.000
O72 Postpartum haemorrhage
0.635 0.365 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.634 0.366 0.000
C50.5 Lower-outer quadrant of breast
0.634 0.366 0.000
N60.9 Benign mammary dysplasia, unspecified
0.634 0.366 0.000
N05 Unspecified nephritic syndrome
0.633 0.366 0.000
O66 Other obstructed labour
0.634 0.366 0.000
M79.60 Pain in limb (Multiple sites)
0.632 0.367 0.000
M15 Polyarthrosis
0.632 0.368 0.000
M83 Adult osteomalacia
0.630 0.370 0.000
M82 Osteoporosis in diseases classified elsewhere
0.630 0.370 0.000
N97 Female infertility
0.630 0.370 0.000
M79.83 Other specified soft tissue disorders (Forearm)
0.630 0.370 0.000
M79.81 Other specified soft tissue disorders (Shoulder region)
0.630 0.370 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.629 0.371 0.000
C25 Malignant neoplasm of pancreas
0.628 0.372 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.627 0.373 0.000
G90-G99 Other disorders of the nervous system
0.627 0.373 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.627 0.373 0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.627 0.373 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.627 0.373 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.627 0.373 0.000
M06.04 Seronegative rheumatoid arthritis (Hand)
0.627 0.373 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.627 0.373 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.627 0.373 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.627 0.373 0.000
G51.0 Bell's palsy
0.627 0.373 0.000
N94.5 Secondary dysmenorrhoea
0.627 0.373 0.000
N94.4 Primary dysmenorrhoea
0.627 0.373 0.000
N94.2 Vaginismus
0.627 0.373 0.000
N94.0 Mittelschmerz
0.627 0.373 0.000
N64.4 Mastodynia
0.626 0.374 0.000
N64.3 Galactorrhoea not associated with childbirth
0.626 0.374 0.000
N64.2 Atrophy of breast
0.626 0.374 0.000
N64.0 Fissure and fistula of nipple
0.626 0.374 0.000
H40.8 Other glaucoma
0.626 0.374 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.625 0.375 0.000
M19.8 Other specified arthrosis
0.625 0.375 0.000
M19.2 Other secondary arthrosis
0.625 0.375 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.623 0.377 0.000
D30.0 Kidney
0.623 0.377 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.623 0.377 0.000
D28.2 Uterine tubes and ligaments
0.623 0.377 0.000
N18.8 Other chronic renal failure
0.622 0.378 0.000
N18.1 Chronic kidney disease, stage 1
0.622 0.378 0.000
H60-H62 Diseases of external ear
0.622 0.378 0.000
E11.2 With renal complications
0.619 0.381 0.000
E11.3 With ophthalmic complications
0.618 0.382 0.000
M79.54 Residual foreign body in soft tissue (Hand)
0.618 0.382 0.000
H02.8 Other specified disorders of eyelid
0.616 0.384 0.000
I77.1 Stricture of artery
0.615 0.385 0.000
H26.9 Cataract, unspecified
0.615 0.385 0.000
N64.5 Other signs and symptoms in breast
0.614 0.385 0.000
O62 Abnormalities of forces of labour
0.614 0.386 0.000
G70 Myasthenia gravis and other myoneural disorders
0.614 0.386 0.000
M71.26 Synovial cyst of popliteal space [Baker]-Lower Leg
0.613 0.387 0.000
N18.4 Chronic kidney disease, stage 4
0.612 0.388 0.000
H02.3 Blepharochalasis
0.612 0.388 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.611 0.388 0.000
E66.1 Drug-induced obesity
0.611 0.388 0.000
E66.0 Obesity due to excess calories
0.611 0.388 0.000
D38.1 Trachea, bronchus and lung
0.611 0.389 0.000
I85 Oesophageal varices
0.611 0.389 0.000
Q51 Congenital malformations of uterus and cervix
0.611 0.389 0.000
I86 Varicose veins of other sites
0.611 0.389 0.000
C04 Malignant neoplasm of floor of mouth
0.610 0.390 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.610 0.390 0.000
M10.4 Other secondary gout
0.609 0.391 0.000
M10.3 Gout due to impairment of renal function
0.609 0.391 0.000
M10.2 Drug-induced gout
0.609 0.391 0.000
M10.1 Lead-induced gout
0.609 0.391 0.000
M10.0 Idiopathic gout
0.609 0.391 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.609 0.391 0.000
N18.2 Chronic kidney disease, stage 2
0.609 0.391 0.000
I72 Other aneurysm
0.609 0.391 0.000
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified
0.608 0.391 0.000
C77.2 Intra-abdominal lymph nodes
0.604 0.396 0.000
D10.9 Pharynx, unspecified
0.604 0.396 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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