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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77851248
log Bayes Factor = 21.7911
Chromosome 21   position 24,570,193  (GRCh37) Explore rs77851248 on Ensembl!
Variant rs77851248 is part of Cluster X0293

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
0.999 0.001 0.000
E10-E14 Diabetes mellitus
0.999 0.001 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.998 0.002 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.998 0.002 0.000
Chapter II Neoplasms
0.997 0.003 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.997 0.003 0.000
Chapter X Diseases of the respiratory system
0.995 0.005 0.000
Chapter VI Diseases of the nervous system
0.992 0.008 0.000
E70-E90 Metabolic disorders
0.992 0.008 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.989 0.011 0.000
M20-M25 Other joint disorders
0.988 0.012 0.000
E10 Insulin-dependent diabetes mellitus
0.987 0.013 0.000
K55-K64 Other diseases of intestines
0.986 0.014 0.000
E11 Non-insulin-dependent diabetes mellitus
0.979 0.021 0.000
N93 Other abnormal uterine and vaginal bleeding
0.975 0.025 0.000
S60-S69 Injuries to the wrist and hand
0.971 0.029 0.000
Chapter I Certain infectious and parasitic diseases
0.971 0.029 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.969 0.031 0.000
N17-N19 Renal failure
0.968 0.032 0.000
J90-J94 Other diseases of pleura
0.961 0.039 0.000
E83 Disorders of mineral metabolism
0.960 0.040 0.000
J95-J99 Other diseases of the respiratory system
0.958 0.042 0.000
K60 Fissure and fistula of anal and rectal regions
0.949 0.051 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.947 0.053 0.000
Chapter XXI Factors influencing health status and contact with health services
0.942 0.058 0.000
E83.5 Disorders of calcium metabolism
0.933 0.067 0.000
J98 Other respiratory disorders
0.931 0.069 0.000
N93.9 Abnormal uterine and vaginal bleeding, unspecified
0.926 0.074 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.924 0.076 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.923 0.077 0.000
M20 Acquired deformities of fingers and toes
0.922 0.078 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.921 0.079 0.000
K60.2 Anal fissure, unspecified
0.918 0.082 0.000
C79 Secondary malignant neoplasm of other sites
0.914 0.086 0.000
G56 Mononeuropathies of upper limb
0.914 0.086 0.000
N85 Other noninflammatory disorders of uterus, except cervix
0.913 0.087 0.000
N30-N39 Other diseases of urinary system
0.912 0.088 0.000
E11.4 With neurological complications
0.910 0.090 0.000
E10.9 Without complications
0.907 0.093 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.905 0.095 0.000
S62 Fracture at wrist and hand level
0.904 0.096 0.000
B95-B98 Bacterial, viral and other infectious agents
0.903 0.097 0.000
N60-N64 Disorders of breast
0.901 0.099 0.000
N93.0 Postcoital and contact bleeding
0.899 0.101 0.000
G90-G99 Other disorders of the nervous system
0.897 0.103 0.000
C15-C26 Malignant neoplasms of digestive organs
0.896 0.104 0.000
K90-K93 Other diseases of the digestive system
0.896 0.104 0.000
K65-K67 Diseases of peritoneum
0.894 0.106 0.000
E10.3 With ophthalmic complications
0.889 0.111 0.000
K59 Other functional intestinal disorders
0.887 0.113 0.000
N10-N16 Renal tubulo-interstitial diseases
0.883 0.117 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.882 0.118 0.000
G56.0 Carpal tunnel syndrome
0.881 0.119 0.000
E11.9 Without complications
0.881 0.119 0.000
N81 Female genital prolapse
0.881 0.119 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.880 0.120 0.000
J92 Pleural plaque
0.880 0.120 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.873 0.127 0.000
M20.5 Other deformities of toe(s) (acquired)
0.872 0.128 0.000
M35 Other systemic involvement of connective tissue
0.872 0.128 0.000
N18 Chronic renal failure
0.871 0.129 0.000
E86 Volume depletion
0.867 0.133 0.000
Chapter XX External causes of morbidity and mortality
0.866 0.134 0.000
J98.1 Pulmonary collapse
0.865 0.135 0.000
K82 Other diseases of gallbladder
0.862 0.138 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.862 0.138 0.000
E50-E64 Other nutritional deficiencies
0.861 0.139 0.000
N83 Noninflammatory disorders of ovary, Fallopian tube and broad ligament
0.860 0.140 0.000
Chapter VII Diseases of the eye and adnexa
0.855 0.145 0.000
S62.6 Fracture of other finger
0.854 0.146 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.854 0.146 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.851 0.149 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.850 0.150 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.850 0.150 0.000
R79 Other abnormal findings of blood chemistry
0.849 0.151 0.000
M80-M85 Disorders of bone density and structure
0.846 0.154 0.000
N17 Acute renal failure
0.846 0.154 0.000
Z45 Adjustment and management of implanted device
0.845 0.155 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.844 0.156 0.000
J30-J39 Other diseases of upper respiratory tract
0.843 0.157 0.000
K83 Other diseases of biliary tract
0.843 0.157 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.842 0.158 0.000
E10.4 With neurological complications
0.841 0.159 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.839 0.161 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.839 0.161 0.000
K56 Paralytic ileus and intestinal obstruction without hernia
0.838 0.162 0.000
K86 Other diseases of pancreas
0.837 0.163 0.000
C80 Malignant neoplasm without specification of site
0.837 0.163 0.000
M05-M14 Inflammatory polyarthropathies
0.837 0.163 0.000
Chapter VIII Diseases of the ear and mastoid process
0.833 0.167 0.000
N85.4 Malposition of uterus
0.829 0.171 0.000
S61 Open wound of wrist and hand
0.828 0.172 0.000
J90 Pleural effusion, not elsewhere classified
0.828 0.172 0.000
M25 Other joint disorders, not elsewhere classified
0.827 0.173 0.000
Chapter IX Diseases of the circulatory system
0.827 0.173 0.000
E10.1 With ketoacidosis
0.826 0.174 0.000
N19 Unspecified renal failure
0.826 0.174 0.000
N60 Benign mammary dysplasia
0.825 0.175 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.824 0.176 0.000
N89 Other noninflammatory disorders of vagina
0.823 0.176 0.000
R79.8 Other specified abnormal findings of blood chemistry
0.823 0.177 0.000
N99-N99 Other disorders of the genitourinary system
0.820 0.180 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.820 0.180 0.000
N35 Urethral stricture
0.820 0.180 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.819 0.181 0.000
E73 Lactose intolerance
0.816 0.184 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.815 0.185 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.814 0.186 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.814 0.186 0.000
C18 Malignant neoplasm of colon
0.813 0.187 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.812 0.188 0.000
Z48 Other surgical follow-up care
0.812 0.188 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.812 0.188 0.000
S90-S99 Injuries to the ankle and foot
0.811 0.189 0.000
M86-M90 Other osteopathies
0.810 0.190 0.000
N87 Dysplasia of cervix uteri
0.808 0.192 0.000
K82.8 Other specified diseases of gallbladder
0.806 0.194 0.000
J98.4 Other disorders of lung
0.805 0.195 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.804 0.196 0.000
N81.6 Rectocele
0.804 0.196 0.000
Z42 Follow-up care involving plastic surgery
0.803 0.197 0.000
M31 Other necrotising vasculopathies
0.803 0.197 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.803 0.197 0.000
N18.3 Chronic kidney disease, stage 3
0.802 0.198 0.000
M23 Internal derangement of knee
0.801 0.199 0.000
N92 Excessive, frequent and irregular menstruation
0.799 0.201 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.799 0.201 0.000
C77.2 Intra-abdominal lymph nodes
0.798 0.202 0.000
S80-S89 Injuries to the knee and lower leg
0.797 0.203 0.000
N13 Obstructive and reflux uropathy
0.796 0.204 0.000
S68 Traumatic amputation of wrist and hand
0.795 0.205 0.000
D00-D09 In situ neoplasms
0.795 0.205 0.000
M65-M68 Disorders of synovium and tendon
0.793 0.206 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.793 0.206 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.790 0.210 0.000
G70-G73 Diseases of myoneural junction and muscle
0.787 0.213 0.000
N85.2 Hypertrophy of uterus
0.786 0.214 0.000
A00-A09 Intestinal infectious diseases
0.786 0.214 0.000
N80 Endometriosis
0.786 0.214 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.784 0.216 0.000
E11.3 With ophthalmic complications
0.783 0.217 0.000
G93 Other disorders of brain
0.783 0.217 0.000
S62.60 Fracture of other finger (closed)
0.782 0.217 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.781 0.219 0.000
K55 Vascular disorders of intestine
0.780 0.219 0.000
N20-N23 Urolithiasis
0.780 0.220 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.778 0.222 0.000
Z45.8 Adjustment and management of other implanted devices
0.777 0.223 0.000
K59.0 Constipation
0.776 0.224 0.000
K66 Other disorders of peritoneum
0.776 0.224 0.000
S40-S49 Injuries to the shoulder and upper arm
0.776 0.224 0.000
Z47 Other orthopaedic follow-up care
0.775 0.225 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.775 0.225 0.000
E14 Unspecified diabetes mellitus
0.774 0.226 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.773 0.227 0.000
C43 Malignant melanoma of skin
0.772 0.228 0.000
C77.5 Intrapelvic lymph nodes
0.771 0.228 0.000
J92.0 Pleural plaque with presence of asbestos
0.770 0.230 0.000
Z60 Problems related to social environment
0.769 0.231 0.000
J09-J18 Influenza and pneumonia
0.768 0.232 0.000
N30 Cystitis
0.768 0.232 0.000
N81.1 Cystocele
0.767 0.233 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.766 0.234 0.000
J34 Other disorders of nose and nasal sinuses
0.766 0.234 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.763 0.237 0.000
K58 Irritable bowel syndrome
0.762 0.238 0.000
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.762 0.238 0.000
Chapter V Mental and behavioural disorders
0.762 0.238 0.000
T66-T78 Other and unspecified effects of external causes
0.761 0.238 0.000
E55 Vitamin D deficiency
0.759 0.240 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.759 0.241 0.000
N17.9 Acute renal failure, unspecified
0.759 0.241 0.000
J93 Pneumothorax
0.758 0.241 0.000
J60-J70 Lung diseases due to external agents
0.755 0.245 0.000
J98.8 Other specified respiratory disorders
0.755 0.245 0.000
N35.9 Urethral stricture, unspecified
0.754 0.246 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.754 0.246 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.753 0.247 0.000
M15-M19 Arthrosis
0.753 0.247 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.750 0.250 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.750 0.250 0.000
E16 Other disorders of pancreatic internal secretion
0.749 0.251 0.000
E83.4 Disorders of magnesium metabolism
0.749 0.251 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.748 0.252 0.000
J92.9 Pleural plaque without asbestos
0.747 0.253 0.000
H30-H36 Disorders of choroid and retina
0.747 0.253 0.000
S69 Other and unspecified injuries of wrist and hand
0.747 0.253 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.744 0.256 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.741 0.259 0.000
I60-I69 Cerebrovascular diseases
0.741 0.259 0.000
G30-G32 Other degenerative diseases of the nervous system
0.741 0.259 0.000
C77.9 Lymph node, unspecified
0.740 0.260 0.000
M40-M43 Deforming dorsopathies
0.740 0.260 0.000
K81 Cholecystitis
0.740 0.260 0.000
K83.8 Other specified diseases of biliary tract
0.740 0.260 0.000
B35-B49 Mycoses
0.739 0.261 0.000
E11.5 With peripheral circulatory complications
0.738 0.262 0.000
J91 Pleural effusion in conditions classified elsewhere
0.738 0.262 0.000
A80-A89 Viral infections of the central nervous system
0.737 0.263 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.736 0.264 0.000
M22 Disorders of patella
0.736 0.264 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.735 0.265 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.735 0.265 0.000
Q60-Q64 Congenital malformations of the urinary system
0.734 0.266 0.000
K70-K77 Diseases of liver
0.734 0.266 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.733 0.267 0.000
S62.61 Fracture of other finger (open)
0.732 0.268 0.000
M35.3 Polymyalgia rheumatica
0.731 0.269 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.731 0.269 0.000
K65 Peritonitis
0.730 0.270 0.000
N90 Other noninflammatory disorders of vulva and perineum
0.730 0.270 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.728 0.272 0.000
E20-E35 Disorders of other endocrine glands
0.728 0.272 0.000
G56.2 Lesion of ulnar nerve
0.728 0.272 0.000
J34.3 Hypertrophy of nasal turbinates
0.727 0.273 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.727 0.273 0.000
S00-S09 Injuries to the head
0.726 0.274 0.000
R20 Disturbances of skin sensation
0.726 0.274 0.000
K59.8 Other specified functional intestinal disorders
0.726 0.274 0.000
R94 Abnormal results of function studies
0.726 0.274 0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified
0.725 0.275 0.000
K60.1 Chronic anal fissure
0.725 0.275 0.000
M24 Other specific joint derangements
0.725 0.275 0.000
M35.0 Sicca syndrome [Sjogren]
0.725 0.275 0.000
C50-C50 Malignant neoplasm of breast
0.724 0.276 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.723 0.277 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.723 0.277 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.723 0.277 0.000
M20.3 Other deformity of hallux (acquired)
0.722 0.278 0.000
Z53 Persons encountering health services for specifie procedures, not carried out
0.722 0.278 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.721 0.279 0.000
Z60.2 Living alone
0.720 0.280 0.000
Z40 Prophylactic surgery
0.720 0.280 0.000
Z45.0 Adjustment and management of cardiac pacemaker
0.719 0.281 0.000
H65-H75 Diseases of middle ear and mastoid
0.719 0.281 0.000
N83.0 Follicular cyst of ovary
0.718 0.282 0.000
Chapter XXII Codes for special purposes
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E40-E46 Malnutrition
0.717 0.283 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.717 0.283 0.000
E13 Other specified diabetes mellitus
0.716 0.284 0.000
E12 Malnutrition-related diabetes mellitus
0.716 0.284 0.000
J35 Chronic diseases of tonsils and adenoids
0.716 0.284 0.000
N98 Complications associated with artificial fertilisation
0.716 0.284 0.000
N91 Absent, scanty and rare menstruation
0.716 0.284 0.000
N82 Fistulae involving female genital tract
0.716 0.284 0.000
N96 Habitual aborter
0.716 0.284 0.000
T79-T79 Certain early complications of trauma
0.715 0.284 0.000
T33-T35 Frostbite
0.715 0.284 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.715 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.715 0.284 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.715 0.284 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.715 0.284 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.715 0.284 0.000
T00-T07 Injuries involving multiple body regions
0.715 0.284 0.000
S10-S19 Injuries to the neck
0.715 0.284 0.000
H53-H54 Visual disturbances and blindness
0.715 0.285 0.000
E87.5 Hyperkalaemia
0.715 0.285 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.715 0.285 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.715 0.285 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.715 0.285 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.715 0.285 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.715 0.285 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.715 0.285 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.714 0.285 0.000
M91-M94 Chondropathies
0.714 0.285 0.000
M60-M63 Disorders of muscles
0.714 0.285 0.000
M00-M03 Infectious arthropathies
0.714 0.285 0.000
C51-C58 Malignant neoplasms of female genital organs
0.714 0.286 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.713 0.287 0.000
B15-B19 Viral hepatitis
0.711 0.288 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.711 0.288 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.711 0.288 0.000
I84 Haemorrhoids
0.711 0.289 0.000
E88 Other metabolic disorders
0.711 0.289 0.000
E85 Amyloidosis
0.711 0.289 0.000
E84 Cystic fibrosis
0.711 0.289 0.000
E79 Disorders of purine and pyrimidine metabolism
0.711 0.289 0.000
E77 Disorders of glycoprotein metabolism
0.711 0.289 0.000
E76 Disorders of glycosaminoglycan metabolism
0.711 0.289 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.711 0.289 0.000
E74 Other disorders of carbohydrate metabolism
0.711 0.289 0.000
E72 Other disorders of amino-acid metabolism
0.711 0.289 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.711 0.289 0.000
E70 Disorders of aromatic amino-acid metabolism
0.711 0.289 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.711 0.289 0.000
R18 Ascites
0.710 0.290 0.000
K86.2 Cyst of pancreas
0.710 0.290 0.000
G63.2 Diabetic polyneuropathy
0.710 0.290 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.710 0.290 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.709 0.291 0.000
A04 Other bacterial intestinal infections
0.709 0.291 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.708 0.291 0.000
M34 Systemic sclerosis
0.708 0.291 0.000
M33 Dermatopolymyositis
0.708 0.291 0.000
M32 Systemic lupus erythematosus
0.708 0.291 0.000
M30 Polyarteritis nodosa and related conditions
0.708 0.291 0.000
M21 Other acquired deformities of limbs
0.708 0.291 0.000
E10.8 With unspecified complications
0.708 0.292 0.000
E10.7 With multiple complications
0.708 0.292 0.000
E10.6 With other specified complications
0.708 0.292 0.000
E10.5 With peripheral circulatory complications
0.708 0.292 0.000
E10.2 With renal complications
0.708 0.292 0.000
E10.0 With coma
0.708 0.292 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.707 0.293 0.000
K64 Haemorrhoids and perianal venous thrombosis
0.707 0.293 0.000
N62 Hypertrophy of breast
0.707 0.293 0.000
C25 Malignant neoplasm of pancreas
0.707 0.293 0.000
G57 Mononeuropathies of lower limb
0.703 0.297 0.000
N81.4 Uterovaginal prolapse, unspecified
0.703 0.297 0.000
K85 Acute pancreatitis
0.702 0.298 0.000
B02 Zoster [herpes zoster]
0.702 0.298 0.000
E11.8 With unspecified complications
0.702 0.298 0.000
E11.7 With multiple complications
0.702 0.298 0.000
E11.6 With other specified complications
0.702 0.298 0.000
E11.2 With renal complications
0.702 0.298 0.000
E11.1 With ketoacidosis
0.702 0.298 0.000
E11.0 With coma
0.702 0.298 0.000
C79.2 Secondary malignant neoplasm of skin
0.700 0.300 0.000
N60.0 Solitary cyst of breast
0.700 0.300 0.000
M81 Osteoporosis without pathological fracture
0.699 0.301 0.000
S67 Crushing injury of wrist and hand
0.696 0.304 0.000
S65 Injury of blood vessels at wrist and hand level
0.696 0.304 0.000
S64 Injury of nerves at wrist and hand level
0.696 0.304 0.000
S60 Superficial injury of wrist and hand
0.696 0.304 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.696 0.304 0.000
B99-B99 Other infectious diseases
0.696 0.304 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.696 0.304 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.696 0.304 0.000
B65-B83 Helminthiases
0.696 0.304 0.000
B50-B64 Protozoal diseases
0.696 0.304 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.696 0.304 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.696 0.304 0.000
A75-A79 Rickettsioses
0.696 0.304 0.000
A70-A74 Other diseases caused by chlamydiae
0.696 0.304 0.000
A65-A69 Other spirochaetal diseases
0.696 0.304 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.696 0.304 0.000
A20-A28 Certain zoonotic bacterial diseases
0.696 0.304 0.000
A15-A19 Tuberculosis
0.696 0.304 0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.695 0.305 0.000
K83.1 Obstruction of bile duct
0.695 0.305 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.694 0.306 0.000
Z53.0 Procedure not carried out because of contraindication
0.694 0.306 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.693 0.307 0.000
K91.3 Postoperative intestinal obstruction
0.693 0.307 0.000
Z43 Attention to artificial openings
0.693 0.307 0.000
N18.4 Chronic kidney disease, stage 4
0.693 0.307 0.000
N94.6 Dysmenorrhoea, unspecified
0.692 0.307 0.000
G91 Hydrocephalus
0.692 0.308 0.000
L82 Seborrhoeic keratosis
0.692 0.308 0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified
0.692 0.308 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.691 0.309 0.000
C18.7 Sigmoid colon
0.690 0.310 0.000
E73.9 Lactose intolerance, unspecified
0.690 0.310 0.000
J98.0 Diseases of bronchus, not elsewhere classified
0.690 0.310 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.689 0.311 0.000
S20-S29 Injuries to the thorax
0.689 0.311 0.000
J94 Other pleural conditions
0.689 0.311 0.000
N92.6 Irregular menstruation, unspecified
0.688 0.312 0.000
M23.8 Other internal derangements of knee
0.688 0.312 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.688 0.312 0.000
E83.8 Other disorders of mineral metabolism
0.688 0.312 0.000
E83.3 Disorders of phosphorus metabolism
0.688 0.312 0.000
E83.2 Disorders of zinc metabolism
0.688 0.312 0.000
E83.0 Disorders of copper metabolism
0.688 0.312 0.000
K56.2 Volvulus
0.688 0.312 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.687 0.313 0.000
J96 Respiratory failure, not elsewhere classified
0.687 0.313 0.000
C77.3 Axillary and upper limb lymph nodes
0.687 0.313 0.000
K11 Diseases of salivary glands
0.687 0.313 0.000
E55.9 Vitamin D deficiency, unspecified
0.687 0.313 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.687 0.313 0.000
H55-H59 Other disorders of eye and adnexa
0.686 0.314 0.000
A30-A49 Other bacterial diseases
0.684 0.316 0.000
R11 Nausea and vomiting
0.682 0.318 0.000
T92 Sequelae of injuries of upper limb
0.682 0.318 0.000
Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device
0.682 0.318 0.000
Z48.0 Attention to surgical dressings and sutures
0.682 0.318 0.000
N13.3 Other and unspecified hydronephrosis
0.681 0.319 0.000
C80.9 Malignant neoplasm, unspecified
0.681 0.319 0.000
K60.5 Anorectal fistula
0.681 0.319 0.000
K60.4 Rectal fistula
0.681 0.319 0.000
K60.0 Acute anal fissure
0.681 0.319 0.000
S50-S59 Injuries to the elbow and forearm
0.680 0.320 0.000
M13 Other arthritis
0.679 0.321 0.000
K61 Abscess of anal and rectal regions
0.679 0.321 0.000
K01 Embedded and impacted teeth
0.679 0.321 0.000
N86 Erosion and ectropion of cervix uteri
0.679 0.321 0.000
G58 Other mononeuropathies
0.679 0.321 0.000
G54 Nerve root and plexus disorders
0.679 0.321 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.679 0.321 0.000
G52 Disorders of other cranial nerves
0.679 0.321 0.000
M25.5 Pain in joint
0.679 0.321 0.000
S61.0 Open wound of finger(s) without damage to nail
0.678 0.322 0.000
K57 Diverticular disease of intestine
0.678 0.322 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.678 0.322 0.000
S92 Fracture of foot, except ankle
0.678 0.322 0.000
M05 Seropositive rheumatoid arthritis
0.678 0.322 0.000
N80.8 Other endometriosis
0.677 0.323 0.000
J00-J06 Acute upper respiratory infections
0.677 0.323 0.000
K60.3 Anal fistula
0.675 0.325 0.000
E16.2 Hypoglycaemia, unspecified
0.674 0.326 0.000
W20-W49 Exposure to inanimate mechanical forces
0.674 0.326 0.000
S70-S79 Injuries to the hip and thigh
0.673 0.327 0.000
N00-N08 Glomerular diseases
0.673 0.327 0.000
K13 Other diseases of lip and oral mucosa
0.673 0.327 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.673 0.327 0.000
J36 Peritonsillar abscess
0.672 0.328 0.000
C80.0 Malignant neoplasm, primary site unknown, so stated
0.672 0.328 0.000
A04.8 Other specified bacterial intestinal infections
0.672 0.328 0.000
N64 Other disorders of breast
0.671 0.329 0.000
N83.1 Corpus luteum cyst
0.671 0.329 0.000
M80 Osteoporosis with pathological fracture
0.671 0.329 0.000
K08 Other disorders of teeth and supporting structures
0.671 0.329 0.000
M31.6 Other giant cell arteritis
0.671 0.329 0.000
N89.8 Other specified noninflammatory disorders of vagina
0.670 0.330 0.000
L40-L45 Papulosquamous disorders
0.670 0.330 0.000
S68.1 Traumatic amputation of other single finger (complete)(partial)
0.669 0.331 0.000
H36 Retinal disorders in diseases classified elsewhere
0.669 0.331 0.000
N94.1 Dyspareunia
0.668 0.332 0.000
Z42.1 Follow-up care involving plastic surgery of breast
0.668 0.332 0.000
G61 Inflammatory polyneuropathy
0.668 0.332 0.000
J98.9 Respiratory disorder, unspecified
0.668 0.332 0.000
J98.6 Disorders of diaphragm
0.668 0.332 0.000
J98.5 Diseases of mediastinum, not elsewhere classified
0.668 0.332 0.000
J98.3 Compensatory emphysema
0.668 0.332 0.000
J98.2 Interstitial emphysema
0.668 0.332 0.000
K56.6 Other and unspecified intestinal obstruction
0.667 0.332 0.000
H10-H13 Disorders of conjunctiva
0.667 0.333 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.667 0.333 0.000
O80-O84 Delivery
0.667 0.333 0.000
L03 Cellulitis
0.667 0.333 0.000
G93.3 Postviral fatigue syndrome
0.666 0.334 0.000
T93 Sequelae of injuries of lower limb
0.665 0.335 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.665 0.335 0.000
N60.8 Other benign mammary dysplasias
0.665 0.335 0.000
K04 Diseases of pulp and periapical tissues
0.664 0.336 0.000
C20 Malignant neoplasm of rectum
0.664 0.336 0.000
I84.8 Unspecified haemorrhoids with other complications
0.664 0.336 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.663 0.337 0.000
G50 Disorders of trigeminal nerve
0.663 0.337 0.000
C78.2 Secondary malignant neoplasm of pleura
0.663 0.337 0.000
C43.6 Malignant melanoma of upper limb, including shoulder
0.663 0.337 0.000
E83.1 Disorders of iron metabolism
0.663 0.337 0.000
Z42.0 Follow-up care involving plastic surgery of head and neck
0.662 0.337 0.000
L10-L14 Bullous disorders
0.662 0.338 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.662 0.338 0.000
N23 Unspecified renal colic
0.662 0.338 0.000
K80 Cholelithiasis
0.662 0.338 0.000
R94.5 Abnormal results of liver function studies
0.661 0.339 0.000
N87.0 Mild cervical dysplasia
0.661 0.339 0.000
K86.9 Disease of pancreas, unspecified
0.661 0.339 0.000
M20.0 Deformity of finger(s)
0.661 0.339 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.661 0.339 0.000
R73 Elevated blood glucose level
0.660 0.340 0.000
Z50 Care involving use of rehabilitation procedures
0.660 0.340 0.000
Z54 Convalescence
0.660 0.340 0.000
Z52 Donors of organs and tissues
0.660 0.340 0.000
Z49 Care involving dialysis
0.660 0.340 0.000
Z44 Fitting and adjustment of external prosthetic device
0.660 0.340 0.000
K91.4 Colostomy and enterostomy malfunction
0.659 0.341 0.000
W00-W19 Falls
0.659 0.341 0.000
N13.8 Other obstructive and reflux uropathy
0.658 0.341 0.000
S62.3 Fracture of other metacarpal bone
0.658 0.342 0.000
E87.2 Acidosis
0.658 0.342 0.000
K35-K38 Diseases of appendix
0.657 0.343 0.000
M20.4 Other hammer toe(s) (acquired)
0.657 0.343 0.000
N83.2 Other and unspecified ovarian cysts
0.657 0.343 0.000
C18.0 Caecum
0.657 0.343 0.000
N97 Female infertility
0.656 0.344 0.000
N92.5 Other specified irregular menstruation
0.656 0.344 0.000
E00-E07 Disorders of thyroid gland
0.656 0.344 0.000
K66.0 Peritoneal adhesions
0.655 0.344 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.655 0.345 0.000
C79.6 Secondary malignant neoplasm of ovary
0.655 0.345 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.655 0.345 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.655 0.345 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.655 0.345 0.000
G56.9 Mononeuropathy of upper limb, unspecified
0.655 0.345 0.000
G56.8 Other mononeuropathies of upper limb
0.655 0.345 0.000
G56.4 Causalgia
0.655 0.345 0.000
G56.3 Lesion of radial nerve
0.655 0.345 0.000
G56.1 Other lesions of median nerve
0.655 0.345 0.000
N25-N29 Other disorders of kidney and ureter
0.655 0.345 0.000
N85.9 Noninflammatory disorder of uterus, unspecified
0.654 0.345 0.000
N85.7 Haematometra
0.654 0.345 0.000
N85.6 Intra-uterine synechiae
0.654 0.345 0.000
N85.5 Inversion of uterus
0.654 0.345 0.000
N85.3 Subinvolution of uterus
0.654 0.345 0.000
N85.1 Endometrial adenomatous hyperplasia
0.654 0.345 0.000
N37 Urethral disorders in diseases classified elsewhere
0.654 0.346 0.000
N36 Other disorders of urethra
0.654 0.346 0.000
N34 Urethritis and urethral syndrome
0.654 0.346 0.000
N33 Bladder disorders in diseases classified elsewhere
0.654 0.346 0.000
N61 Inflammatory disorders of breast
0.654 0.346 0.000
S61.9 Open wound of wrist and hand, part unspecified
0.653 0.346 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.653 0.346 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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