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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs78008978
log Bayes Factor = 13.3787
Chromosome 12   position 77,282,680  (GRCh37) Explore rs78008978 on Ensembl!
Variant rs78008978 is part of Cluster X0072

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
M70-M79 Other soft tissue disorders
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
1.000 0.000 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.998 0.002 0.000
Chapter V Mental and behavioural disorders
0.997 0.003 0.000
Chapter I Certain infectious and parasitic diseases
0.996 0.004 0.000
M75 Shoulder lesions
0.993 0.007 0.000
M79.0 Rheumatism, unspecified
0.989 0.011 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.989 0.011 0.000
Chapter XX External causes of morbidity and mortality
0.986 0.014 0.000
J90-J94 Other diseases of pleura
0.984 0.016 0.000
F30-F39 Mood [affective] disorders
0.982 0.018 0.000
J09-J18 Influenza and pneumonia
0.982 0.018 0.000
B95-B98 Bacterial, viral and other infectious agents
0.981 0.019 0.000
M79.09 Rheumatism, unspecified (Site unspecified)
0.980 0.020 0.000
J18 Pneumonia, organism unspecified
0.968 0.032 0.000
Chapter VII Diseases of the eye and adnexa
0.960 0.040 0.000
J90 Pleural effusion, not elsewhere classified
0.958 0.042 0.000
J18.1 Lobar pneumonia, unspecified
0.951 0.049 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.947 0.053 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.947 0.053 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.942 0.058 0.000
M75.1 Rotator cuff syndrome
0.935 0.065 0.000
M75.4 Impingement syndrome of shoulder
0.933 0.067 0.000
M79.6 Pain in limb
0.930 0.070 0.000
F32 Depressive episode
0.928 0.072 0.000
J30-J39 Other diseases of upper respiratory tract
0.921 0.079 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.919 0.081 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.917 0.083 0.000
J92 Pleural plaque
0.915 0.085 0.000
S20-S29 Injuries to the thorax
0.914 0.086 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.910 0.090 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.910 0.090 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.900 0.100 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.893 0.107 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.891 0.109 0.000
M75.3 Calcific tendinitis of shoulder
0.891 0.109 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.889 0.111 0.000
Chapter VIII Diseases of the ear and mastoid process
0.885 0.115 0.000
Chapter XXII Codes for special purposes
0.881 0.119 0.000
M20-M25 Other joint disorders
0.879 0.121 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.879 0.121 0.000
J92.9 Pleural plaque without asbestos
0.875 0.125 0.000
J18.9 Pneumonia, unspecified
0.875 0.125 0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters
0.874 0.126 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.872 0.128 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.870 0.130 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.867 0.133 0.000
J35 Chronic diseases of tonsils and adenoids
0.863 0.137 0.000
X60-X84 Intentional self-harm
0.862 0.138 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.859 0.141 0.000
F33 Recurrent depressive disorder
0.858 0.142 0.000
M40-M43 Deforming dorsopathies
0.856 0.143 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.856 0.144 0.000
H30-H36 Disorders of choroid and retina
0.855 0.144 0.000
V10-V19 Pedal cyclist injured in transport accident
0.854 0.146 0.000
H65-H75 Diseases of middle ear and mastoid
0.853 0.147 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.851 0.149 0.000
T66-T78 Other and unspecified effects of external causes
0.850 0.150 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.849 0.151 0.000
A00-A09 Intestinal infectious diseases
0.845 0.155 0.000
T43.2 Other and unspecified antidepressants
0.840 0.160 0.000
F32.3 Severe depressive episode with psychotic symptoms
0.840 0.160 0.000
T92 Sequelae of injuries of upper limb
0.839 0.161 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.838 0.162 0.000
M79.63 Pain in limb (Forearm)
0.838 0.162 0.000
T18 Foreign body in alimentary tract
0.837 0.163 0.000
M05-M14 Inflammatory polyarthropathies
0.831 0.169 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.828 0.172 0.000
J00-J06 Acute upper respiratory infections
0.827 0.173 0.000
B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
0.827 0.173 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.824 0.176 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.821 0.179 0.000
J34 Other disorders of nose and nasal sinuses
0.820 0.180 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.817 0.183 0.000
J35.0 Chronic tonsillitis
0.814 0.186 0.000
H35 Other retinal disorders
0.814 0.186 0.000
S60-S69 Injuries to the wrist and hand
0.812 0.188 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.812 0.188 0.000
Y42.7 Androgens and anabolic congeners
0.811 0.189 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.808 0.192 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.808 0.192 0.000
F31 Bipolar affective disorder
0.808 0.192 0.000
L92 Granulomatous disorders of skin and subcutaneous tissue
0.807 0.193 0.000
B35-B49 Mycoses
0.806 0.194 0.000
M25 Other joint disorders, not elsewhere classified
0.804 0.196 0.000
Y42.5 Other oestrogens and progestogens
0.803 0.197 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.802 0.198 0.000
J32 Chronic sinusitis
0.800 0.200 0.000
M79.00 Rheumatism, unspecified (Multiple sites)
0.799 0.201 0.000
B97.8 Other viral agents as the cause of diseases classified to other chapters
0.799 0.201 0.000
M79.7 Fibromyalgia
0.798 0.202 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.798 0.202 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.797 0.203 0.000
L60-L75 Disorders of skin appendages
0.796 0.204 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.794 0.206 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.793 0.207 0.000
F10.3 Withdrawal state
0.793 0.207 0.000
A04 Other bacterial intestinal infections
0.790 0.210 0.000
F10.1 Harmful use
0.789 0.211 0.000
J95-J99 Other diseases of the respiratory system
0.789 0.211 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.788 0.212 0.000
T18.1 Foreign body in oesophagus
0.785 0.215 0.000
L40-L45 Papulosquamous disorders
0.784 0.216 0.000
J40-J47 Chronic lower respiratory diseases
0.784 0.216 0.000
S90-S99 Injuries to the ankle and foot
0.783 0.217 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.783 0.217 0.000
F30 Manic episode
0.781 0.219 0.000
T79-T79 Certain early complications of trauma
0.780 0.220 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.780 0.220 0.000
H52 Disorders of refraction and accommodation
0.779 0.221 0.000
J81 Pulmonary oedema
0.779 0.221 0.000
M25.5 Pain in joint
0.778 0.222 0.000
H18 Other disorders of cornea
0.775 0.225 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.774 0.226 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.774 0.226 0.000
Chapter XIV Diseases of the genitourinary system
0.773 0.227 0.000
F32.0 Mild depressive episode
0.769 0.231 0.000
M45-M49 Spondylopathies
0.769 0.231 0.000
J44 Other chronic obstructive pulmonary disease
0.769 0.231 0.000
N17-N19 Renal failure
0.769 0.231 0.000
J60-J70 Lung diseases due to external agents
0.768 0.232 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.767 0.233 0.000
H55-H59 Other disorders of eye and adnexa
0.767 0.233 0.000
M65-M68 Disorders of synovium and tendon
0.765 0.235 0.000
V20-V29 Motorcycle rider injured in transport accident
0.765 0.235 0.000
J11 Influenza, virus not identified
0.764 0.236 0.000
M75.5 Bursitis of shoulder
0.763 0.236 0.000
M24 Other specific joint derangements
0.762 0.238 0.000
T40.2 Other opioids
0.761 0.239 0.000
M00-M03 Infectious arthropathies
0.760 0.240 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.760 0.240 0.000
M86-M90 Other osteopathies
0.760 0.240 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.759 0.241 0.000
M79.1 Myalgia
0.758 0.242 0.000
F99-F99 Unspecified mental disorder
0.756 0.244 0.000
M35 Other systemic involvement of connective tissue
0.756 0.244 0.000
Y48 Anaesthetics and therapeutic gases
0.756 0.244 0.000
Y52 Agents primarily affecting the cardiovascular system
0.755 0.245 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.755 0.245 0.000
D69 Purpura and other haemorrhagic conditions
0.754 0.246 0.000
N17 Acute renal failure
0.753 0.247 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.752 0.248 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.752 0.248 0.000
H65 Nonsuppurative otitis media
0.751 0.249 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.750 0.250 0.000
M60-M63 Disorders of muscles
0.749 0.251 0.000
H35.3 Degeneration of macula and posterior pole
0.749 0.251 0.000
M91-M94 Chondropathies
0.749 0.251 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.748 0.252 0.000
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified
0.748 0.252 0.000
M50-M54 Other dorsopathies
0.747 0.253 0.000
H71 Cholesteatoma of middle ear
0.746 0.254 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.745 0.255 0.000
M72 Fibroblastic disorders
0.744 0.255 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.743 0.257 0.000
M79.67 Pain in limb (Ankle and foot)
0.743 0.257 0.000
H43-H45 Disorders of vitreous body and globe
0.742 0.258 0.000
M13 Other arthritis
0.741 0.259 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.740 0.260 0.000
N17.9 Acute renal failure, unspecified
0.739 0.261 0.000
B25-B34 Other viral diseases
0.737 0.263 0.000
S27 Injury of other and unspecified intrathoracic organs
0.737 0.263 0.000
J10 Influenza due to identified influenza virus
0.736 0.264 0.000
S00-S09 Injuries to the head
0.736 0.264 0.000
F10.0 Acute intoxication
0.736 0.264 0.000
V80-V89 Other land transport accidents
0.735 0.265 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.735 0.265 0.000
M71 Other bursopathies
0.733 0.266 0.000
M75.2 Bicipital tendinitis
0.731 0.269 0.000
D69.6 Thrombocytopenia, unspecified
0.730 0.270 0.000
H10-H13 Disorders of conjunctiva
0.729 0.271 0.000
A30-A49 Other bacterial diseases
0.729 0.271 0.000
M79.8 Other specified soft tissue disorders
0.729 0.271 0.000
T88.5 Other complications of anaesthesia
0.725 0.275 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.725 0.275 0.000
M25.51 Pain in joint (Shoulder region)
0.724 0.276 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.722 0.278 0.000
Y42.0 Glucocorticoids and synthetic analogs
0.721 0.279 0.000
T78 Adverse effects, not elsewhere classified
0.720 0.280 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.719 0.281 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.718 0.282 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.718 0.282 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.717 0.283 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
M76 Enthesopathies of lower limb, excluding foot
0.717 0.283 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.717 0.283 0.000
B15-B19 Viral hepatitis
0.717 0.283 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.717 0.283 0.000
M75.9 Shoulder lesion, unspecified
0.716 0.284 0.000
M79.9 Soft tissue disorder, unspecified
0.716 0.284 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.716 0.284 0.000
M79.3 Panniculitis, unspecified
0.716 0.284 0.000
M79.2 Neuralgia and neuritis, unspecified
0.716 0.284 0.000
F32.2 Severe depressive episode without psychotic symptoms
0.715 0.285 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.715 0.285 0.000
F80-F89 Disorders of psychological development
0.715 0.285 0.000
F70-F79 Mental retardation
0.715 0.285 0.000
B99-B99 Other infectious diseases
0.714 0.286 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.714 0.286 0.000
B65-B83 Helminthiases
0.714 0.286 0.000
B50-B64 Protozoal diseases
0.714 0.286 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.714 0.286 0.000
A75-A79 Rickettsioses
0.714 0.286 0.000
A70-A74 Other diseases caused by chlamydiae
0.714 0.286 0.000
A65-A69 Other spirochaetal diseases
0.714 0.286 0.000
A20-A28 Certain zoonotic bacterial diseases
0.714 0.286 0.000
A15-A19 Tuberculosis
0.714 0.286 0.000
H35.0 Background retinopathy and retinal vascular changes
0.712 0.288 0.000
M75.8 Other shoulder lesions
0.712 0.288 0.000
A04.8 Other specified bacterial intestinal infections
0.711 0.289 0.000
T92.5 Sequelae of injury of muscle and tendon of upper limb
0.710 0.290 0.000
X78 Intentional self-harm by sharp object
0.710 0.290 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.710 0.290 0.000
M79.08 Rheumatism, unspecified (Other)
0.709 0.291 0.000
M79.07 Rheumatism, unspecified (Ankle and foot)
0.709 0.291 0.000
M79.06 Rheumatism, unspecified (Lower leg)
0.709 0.291 0.000
M79.05 Rheumatism, unspecified (Pelvic region and thigh)
0.709 0.291 0.000
M79.04 Rheumatism, unspecified (Hand)
0.709 0.291 0.000
M79.03 Rheumatism, unspecified (Forearm)
0.709 0.291 0.000
M79.02 Rheumatism, unspecified (Upper arm)
0.709 0.291 0.000
M79.01 Rheumatism, unspecified (Shoulder region)
0.709 0.291 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.709 0.291 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.709 0.291 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.709 0.291 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.709 0.291 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.709 0.291 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.709 0.291 0.000
T36 Poisoning by systemic antibiotics
0.709 0.291 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.709 0.291 0.000
F60-F69 Disorders of adult personality and behaviour
0.708 0.292 0.000
J82 Pulmonary eosinophilia, not elsewhere classified
0.708 0.292 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.707 0.293 0.000
Y35-Y36 Legal intervention and operations of war
0.707 0.293 0.000
Y10-Y34 Event of undetermined intent
0.707 0.293 0.000
Y00-Y09 Assault
0.707 0.293 0.000
X85-X99 Assault
0.707 0.293 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.707 0.293 0.000
X50-X57 Overexertion, travel and privation
0.707 0.293 0.000
X30-X39 Exposure to forces of nature
0.707 0.293 0.000
X20-X29 Contact with venomous animals and plants
0.707 0.293 0.000
X10-X19 Contact with heat and hot substances
0.707 0.293 0.000
X00-X09 Exposure to smoke, fire and flames
0.707 0.293 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.707 0.293 0.000
W75-W84 Other accidental threats to breathing
0.707 0.293 0.000
W65-W74 Accidental drowning and submersion
0.707 0.293 0.000
W50-W64 Exposure to animate mechanical forces
0.707 0.293 0.000
V98-V99 Other and unspecified transport accidents
0.707 0.293 0.000
V95-V97 Air and space transport accidents
0.707 0.293 0.000
V90-V94 Water transport accidents
0.707 0.293 0.000
V70-V79 Bus occupant injured in transport accident
0.707 0.293 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.707 0.293 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.707 0.293 0.000
V40-V49 Car occupant injured in transport accident
0.707 0.293 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.707 0.293 0.000
V01-V09 Pedestrian injured in transport accident
0.707 0.293 0.000
M79.60 Pain in limb (Multiple sites)
0.707 0.293 0.000
W20-W49 Exposure to inanimate mechanical forces
0.706 0.294 0.000
J94 Other pleural conditions
0.706 0.294 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.705 0.295 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.704 0.296 0.000
M80-M85 Disorders of bone density and structure
0.704 0.296 0.000
F38 Other mood [affective] disorders
0.704 0.296 0.000
F34 Persistent mood [affective] disorders
0.704 0.296 0.000
F39 Unspecified mood [affective] disorder
0.704 0.296 0.000
J17 Pneumonia in diseases classified elsewhere
0.704 0.296 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.704 0.296 0.000
J12 Viral pneumonia, not elsewhere classified
0.704 0.296 0.000
J14 Pneumonia due to Haemophilus influenzae
0.704 0.296 0.000
J09 Influenza due to certain identified influenza virus
0.704 0.296 0.000
F32.1 Moderate depressive episode
0.703 0.297 0.000
H53-H54 Visual disturbances and blindness
0.702 0.298 0.000
J35.9 Chronic disease of tonsils and adenoids, unspecified
0.701 0.299 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.701 0.299 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.700 0.299 0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.700 0.300 0.000
M43 Other deforming dorsopathies
0.699 0.301 0.000
M32 Systemic lupus erythematosus
0.699 0.301 0.000
S70-S79 Injuries to the hip and thigh
0.699 0.301 0.000
J02 Acute pharyngitis
0.699 0.301 0.000
T14 Injury of unspecified body region
0.699 0.301 0.000
M41 Scoliosis
0.698 0.302 0.000
M34 Systemic sclerosis
0.698 0.302 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.696 0.303 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.696 0.304 0.000
S22.2 Fracture of sternum
0.696 0.304 0.000
H50 Other strabismus
0.696 0.304 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.695 0.305 0.000
F20 Schizophrenia
0.695 0.305 0.000
L95 Vasculitis limited to skin, not elsewhere classified
0.695 0.305 0.000
J18.8 Other pneumonia, organism unspecified
0.694 0.306 0.000
J18.2 Hypostatic pneumonia, unspecified
0.694 0.306 0.000
T39.1 4-Aminophenol derivatives
0.694 0.306 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.694 0.306 0.000
A80-A89 Viral infections of the central nervous system
0.693 0.307 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.693 0.307 0.000
F10.4 Withdrawal state with delirium
0.690 0.310 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.690 0.310 0.000
L03 Cellulitis
0.690 0.310 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.690 0.310 0.000
M79.5 Residual foreign body in soft tissue
0.688 0.312 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.688 0.312 0.000
L50-L54 Urticaria and erythema
0.687 0.313 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.686 0.314 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.686 0.314 0.000
V18.0 Driver injured in nontraffic accident
0.685 0.315 0.000
A04.7 Enterocolitis due to Clostridium difficile
0.685 0.315 0.000
Y57 Other and unspecified drugs and medicaments
0.684 0.316 0.000
T17 Foreign body in respiratory tract
0.684 0.316 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.684 0.316 0.000
T51 Toxic effect of alcohol
0.684 0.316 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.683 0.316 0.000
M79.64 Pain in limb (Hand)
0.683 0.317 0.000
S40-S49 Injuries to the shoulder and upper arm
0.682 0.317 0.000
M31 Other necrotising vasculopathies
0.682 0.318 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.681 0.318 0.000
B35 Dermatophytosis
0.680 0.320 0.000
N18 Chronic renal failure
0.680 0.320 0.000
S22.4 Multiple fractures of ribs
0.680 0.320 0.000
T87 Complications peculiar to reattachment and amputation
0.679 0.321 0.000
H49 Paralytic strabismus
0.679 0.321 0.000
L10-L14 Bullous disorders
0.679 0.321 0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.679 0.321 0.000
Y59 Other and unspecified vaccines and biological substances
0.679 0.321 0.000
Y58 Bacterial vaccines
0.679 0.321 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.679 0.321 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.679 0.321 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.679 0.321 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.679 0.321 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.679 0.321 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.679 0.321 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.679 0.321 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.679 0.321 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.679 0.321 0.000
H60-H62 Diseases of external ear
0.678 0.322 0.000
L89 Decubitus ulcer
0.677 0.323 0.000
M79.62 Pain in limb (Upper arm)
0.676 0.324 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.675 0.325 0.000
Y40 Systemic antibiotics
0.675 0.325 0.000
J32.9 Chronic sinusitis, unspecified
0.675 0.325 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.672 0.328 0.000
M35.3 Polymyalgia rheumatica
0.672 0.328 0.000
H18.9 Disorder of cornea, unspecified
0.671 0.329 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.670 0.330 0.000
M24.1 Other articular cartilage disorders
0.670 0.330 0.000
H69 Other disorders of Eustachian tube
0.669 0.331 0.000
S20 Superficial injury of thorax
0.669 0.331 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.669 0.331 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.669 0.331 0.000
M79.69 Pain in limb (Site unspecified)
0.668 0.331 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.668 0.332 0.000
T92.1 Sequelae of fracture of arm
0.667 0.333 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.667 0.333 0.000
M79.68 Pain in limb (Other)
0.667 0.333 0.000
M79.61 Pain in limb (Shoulder region)
0.667 0.333 0.000
M13.9 Arthritis, unspecified
0.667 0.333 0.000
F32.8 Other depressive episodes
0.665 0.335 0.000
H52.2 Astigmatism
0.662 0.338 0.000
F43 Reaction to severe stress, and adjustment disorders
0.661 0.339 0.000
S29 Other and unspecified injuries of thorax
0.661 0.339 0.000
S01 Open wound of head
0.661 0.339 0.000
J37 Chronic laryngitis and laryngotracheitis
0.660 0.340 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.660 0.340 0.000
L92.3 Foreign body granuloma of skin and subcutaneous tissue
0.659 0.341 0.000
M77 Other enthesopathies
0.657 0.342 0.000
N25-N29 Other disorders of kidney and ureter
0.658 0.342 0.000
T43.9 Psychotropic drug, unspecified
0.657 0.343 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.657 0.343 0.000
T43.6 Psychostimulants with abuse potential
0.657 0.343 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.657 0.343 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.657 0.343 0.000
S61 Open wound of wrist and hand
0.657 0.343 0.000
H73 Other disorders of tympanic membrane
0.656 0.344 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.655 0.345 0.000
S26 Injury of heart
0.655 0.345 0.000
S25 Injury of blood vessels of thorax
0.655 0.345 0.000
S24 Injury of nerves and spinal cord at thorax level
0.655 0.345 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.655 0.345 0.000
S21 Open wound of thorax
0.655 0.345 0.000
M25.50 Pain in joint (Multiple sites)
0.655 0.345 0.000
T42.4 Benzodiazepines
0.655 0.345 0.000
M70.2 Olecranon bursitis
0.654 0.346 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.654 0.346 0.000
H57 Other disorders of eye and adnexa
0.654 0.346 0.000
F32.9 Depressive episode, unspecified
0.654 0.346 0.000
J84 Other interstitial pulmonary diseases
0.653 0.346 0.000
L60 Nail disorders
0.653 0.346 0.000
T19 Foreign body in genito-urinary tract
0.653 0.347 0.000
T15 Foreign body on external eye
0.653 0.347 0.000
T16 Foreign body in ear
0.653 0.347 0.000
Y42.9 Other and unspecified hormone antagonists
0.653 0.347 0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified
0.653 0.347 0.000
Y42.4 Oral contraceptives
0.653 0.347 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.653 0.347 0.000
Y42.2 Antithyroid drugs
0.653 0.347 0.000
Y42.1 Thyroid hormones and substitutes
0.653 0.347 0.000
H34 Retinal vascular occlusions
0.652 0.348 0.000
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.651 0.349 0.000
T68 Hypothermia
0.650 0.349 0.000
M25.56 Pain in joint (Lower leg)
0.650 0.350 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.650 0.350 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.649 0.351 0.000
J36 Peritonsillar abscess
0.649 0.351 0.000
B24 Unspecified human immunodeficiency virus [HIV] disease
0.648 0.352 0.000
H74 Other disorders of middle ear and mastoid
0.648 0.352 0.000
T91 Sequelae of injuries of neck and trunk
0.647 0.353 0.000
S67 Crushing injury of wrist and hand
0.646 0.353 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.645 0.354 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.645 0.354 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.645 0.354 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.645 0.354 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.645 0.354 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.645 0.354 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.645 0.354 0.000
F11 Mental and behavioural disorders due to use of opioids
0.645 0.354 0.000
J80 Adult respiratory distress syndrome
0.646 0.354 0.000
T86 Failure and rejection of transplanted organs and tissues
0.645 0.355 0.000
L73 Other follicular disorders
0.645 0.355 0.000
H18.6 Keratoconus
0.644 0.355 0.000
L71 Rosacea
0.642 0.357 0.000
M79.70 Fibromyalgia (Multiple sites)
0.642 0.358 0.000
Y44 Agents primarily affecting blood constituents
0.642 0.358 0.000
J91 Pleural effusion in conditions classified elsewhere
0.640 0.360 0.000
J30 Vasomotor and allergic rhinitis
0.640 0.360 0.000
F25 Schizoaffective disorders
0.639 0.360 0.000
B98.1 Vibrio vulnificus as the cause of diseases classified to other chapters
0.639 0.361 0.000
J35.8 Other chronic diseases of tonsils and adenoids
0.638 0.362 0.000
T98 Sequelae of other and unspecified effects of external causes
0.638 0.362 0.000
T95 Sequelae of burns, corrosions and frostbite
0.638 0.362 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.638 0.362 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.638 0.362 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.638 0.362 0.000
F30.9 Manic episode, unspecified
0.638 0.362 0.000
H52.0 Hypermetropia
0.637 0.363 0.000
J98 Other respiratory disorders
0.636 0.364 0.000
B00 Herpesviral [herpes simplex] infections
0.635 0.365 0.000
L70 Acne
0.634 0.366 0.000
W00-W19 Falls
0.634 0.366 0.000
M05 Seropositive rheumatoid arthritis
0.633 0.367 0.000
F23 Acute and transient psychotic disorders
0.632 0.368 0.000
S22.1 Multiple fractures of thoracic spine
0.632 0.368 0.000
T83.3 Mechanical complication of intra-uterine contraceptive device
0.632 0.368 0.000
H25-H28 Disorders of lens
0.631 0.369 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.630 0.370 0.000
M33 Dermatopolymyositis
0.630 0.370 0.000
M30 Polyarteritis nodosa and related conditions
0.630 0.370 0.000
M53 Other dorsopathies, not elsewhere classified
0.630 0.370 0.000
H51 Other disorders of binocular movement
0.630 0.370 0.000
J32.0 Chronic maxillary sinusitis
0.630 0.370 0.000
S50-S59 Injuries to the elbow and forearm
0.629 0.370 0.000
U80 Agent resistant to penicillin and related antibiotics
0.628 0.372 0.000
J20-J22 Other acute lower respiratory infections
0.628 0.372 0.000
T59 Toxic effect of other gases, fumes and vapours
0.628 0.372 0.000
L03.1 Cellulitis of other parts of limb
0.628 0.372 0.000
H65.0 Acute serous otitis media
0.627 0.373 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.626 0.374 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.626 0.374 0.000
F10.9 Unspecified mental and behavioural disorder
0.625 0.374 0.000
F10.8 Other mental and behavioural disorders
0.625 0.374 0.000
F10.7 Residual and late-onset psychotic disorder
0.625 0.374 0.000
F10.6 Amnesic syndrome
0.625 0.374 0.000
F10.5 Psychotic disorder
0.625 0.374 0.000
N19 Unspecified renal failure
0.625 0.374 0.000
M79.84 Other specified soft tissue disorders (Hand)
0.624 0.375 0.000
L40 Psoriasis
0.624 0.376 0.000
B97.6 Parvovirus as the cause of diseases classified to other chapters
0.624 0.376 0.000
B97.5 Reovirus as the cause of diseases classified to other chapters
0.624 0.376 0.000
B97.4 Respiratory synctial virus as the cause of diseases classified to other chapters
0.624 0.376 0.000
B97.3 Retrovirus as the cause of diseases classified to other chapters
0.624 0.376 0.000
B97.2 Coronavirus as the cause of diseases classified to other chapters
0.624 0.376 0.000
B97.1 Enterovirus as the cause of diseases classified to other chapters
0.624 0.376 0.000
B97.0 Adenovirus as the cause of diseases classified to other chapters
0.624 0.376 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.623 0.377 0.000
L43 Lichen planus
0.623 0.377 0.000
D55-D59 Haemolytic anaemias
0.623 0.377 0.000
L83 Acanthosis nigricans
0.622 0.378 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.621 0.378 0.000
N99-N99 Other disorders of the genitourinary system
0.621 0.379 0.000
L82 Seborrhoeic keratosis
0.620 0.380 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.620 0.380 0.000
S91 Open wound of ankle and foot
0.619 0.381 0.000
J35.3 Hypertrophy of tonsils with hypertrophy of adenoids
0.619 0.381 0.000
J35.2 Hypertrophy of adenoids
0.619 0.381 0.000
M25.59 Pain in joint (Site unspecified)
0.619 0.381 0.000
Y48.3 Local anaesthetics
0.619 0.381 0.000
U81 Agent resistant to vancomycin and related antibiotics
0.619 0.381 0.000
X84 Intentional self-harm by unspecified means
0.618 0.382 0.000
X83 Intentional self-harm by other specified means
0.618 0.382 0.000
X82 Intentional self-harm by crashing of motor vehicle
0.618 0.382 0.000
X81 Intentional self-harm by jumping or lying before moving object
0.618 0.382 0.000
X80 Intentional self-harm by jumping from a high place
0.618 0.382 0.000
X79 Intentional self-harm by blunt object
0.618 0.382 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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