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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs78547629
log Bayes Factor = 16.0951
Chromosome 7   position 145,920,329  (GRCh37) Explore rs78547629 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
0.997 0.003 0.000
M50-M54 Other dorsopathies
0.996 0.004 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.996 0.004 0.000
Chapter XXI Factors influencing health status and contact with health services
0.995 0.005 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.995 0.005 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.993 0.007 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.993 0.007 0.000
R10 Abdominal and pelvic pain
0.993 0.007 0.000
E10-E14 Diabetes mellitus
0.991 0.009 0.000
Chapter IX Diseases of the circulatory system
0.989 0.011 0.000
E14 Unspecified diabetes mellitus
0.989 0.011 0.000
E14.9 Without complications
0.986 0.014 0.000
R10.4 Other and unspecified abdominal pain
0.986 0.014 0.000
Chapter VI Diseases of the nervous system
0.984 0.016 0.000
M20-M25 Other joint disorders
0.982 0.018 0.000
M54 Dorsalgia
0.982 0.018 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.980 0.020 0.000
M25 Other joint disorders, not elsewhere classified
0.976 0.024 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.966 0.034 0.000
I30-I52 Other forms of heart disease
0.965 0.035 0.000
Chapter VIII Diseases of the ear and mastoid process
0.962 0.038 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.957 0.043 0.000
M51 Other intervertebral disk disorders
0.953 0.047 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.950 0.050 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.949 0.051 0.000
R13 Dysphagia
0.949 0.051 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.945 0.055 0.000
R10.3 Pain localised to other parts of lower abdomen
0.943 0.057 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.943 0.057 0.000
M25.7 Osteophyte
0.942 0.058 0.000
I60-I69 Cerebrovascular diseases
0.942 0.058 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.934 0.066 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.930 0.070 0.000
G90-G99 Other disorders of the nervous system
0.927 0.073 0.000
H65-H75 Diseases of middle ear and mastoid
0.925 0.075 0.000
M54.9 Dorsalgia, unspecified
0.920 0.080 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.919 0.081 0.000
M51.2 Other specified intervertebral disk displacement
0.919 0.081 0.000
Chapter V Mental and behavioural disorders
0.916 0.084 0.000
I50 Heart failure
0.914 0.086 0.000
Z57 Occupational exposure to risk-factors
0.911 0.089 0.000
M05-M14 Inflammatory polyarthropathies
0.911 0.089 0.000
E20-E35 Disorders of other endocrine glands
0.905 0.095 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.905 0.095 0.000
I51 Complications and ill-defined descriptions of heart disease
0.901 0.099 0.000
F30-F39 Mood [affective] disorders
0.901 0.099 0.000
M25.5 Pain in joint
0.899 0.101 0.000
I67 Other cerebrovascular diseases
0.897 0.103 0.000
I31 Other diseases of pericardium
0.896 0.104 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.894 0.106 0.000
M54.5 Low back pain
0.894 0.106 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.893 0.107 0.000
Y84.6 Urinary catheterisation
0.893 0.107 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.891 0.109 0.000
M65-M68 Disorders of synovium and tendon
0.887 0.113 0.000
I50.1 Left ventricular failure
0.887 0.113 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.875 0.125 0.000
I20-I25 Ischaemic heart diseases
0.875 0.125 0.000
M25.77 Osteophyte (Ankle and foot)
0.874 0.126 0.000
M24 Other specific joint derangements
0.874 0.126 0.000
R12 Heartburn
0.873 0.127 0.000
S40-S49 Injuries to the shoulder and upper arm
0.872 0.128 0.000
R17 Unspecified jaundice
0.872 0.128 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.871 0.129 0.000
Y83.8 Other surgical procedures
0.868 0.132 0.000
Chapter X Diseases of the respiratory system
0.868 0.132 0.000
Z88.5 Personal history of allergy to narcotic agent
0.868 0.132 0.000
F32 Depressive episode
0.867 0.133 0.000
S60-S69 Injuries to the wrist and hand
0.866 0.134 0.000
O80-O84 Delivery
0.864 0.136 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.864 0.136 0.000
S00-S09 Injuries to the head
0.864 0.136 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.861 0.139 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.860 0.140 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.859 0.141 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.857 0.143 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.857 0.143 0.000
I67.8 Other specified cerebrovascular diseases
0.856 0.144 0.000
F32.9 Depressive episode, unspecified
0.856 0.144 0.000
Z34 Supervision of normal pregnancy
0.856 0.144 0.000
I51.9 Heart disease, unspecified
0.855 0.145 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.852 0.147 0.000
I24 Other acute ischaemic heart diseases
0.851 0.149 0.000
I31.3 Pericardial effusion (noninflammatory)
0.850 0.150 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.843 0.156 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.843 0.157 0.000
R50-R69 General symptoms and signs
0.840 0.160 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.840 0.160 0.000
S10-S19 Injuries to the neck
0.840 0.160 0.000
S70-S79 Injuries to the hip and thigh
0.840 0.160 0.000
Z93 Artificial opening status
0.836 0.164 0.000
M54.59 Low back pain (Site unspecified)
0.836 0.164 0.000
J95-J99 Other diseases of the respiratory system
0.831 0.169 0.000
E11 Non-insulin-dependent diabetes mellitus
0.831 0.169 0.000
H71 Cholesteatoma of middle ear
0.830 0.170 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.828 0.172 0.000
M45-M49 Spondylopathies
0.825 0.175 0.000
H90-H95 Other disorders of ear
0.825 0.175 0.000
Y84.2 Radiological procedure and radiotherapy
0.823 0.177 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.820 0.180 0.000
R59 Enlarged lymph nodes
0.820 0.180 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.819 0.181 0.000
S20-S29 Injuries to the thorax
0.818 0.181 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.818 0.182 0.000
M25.51 Pain in joint (Shoulder region)
0.817 0.183 0.000
M54.4 Lumbago with sciatica
0.817 0.183 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.815 0.185 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.813 0.187 0.000
R10.2 Pelvic and perineal pain
0.812 0.188 0.000
R11 Nausea and vomiting
0.812 0.188 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.810 0.190 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.810 0.190 0.000
Z93.2 Ileostomy status
0.809 0.191 0.000
M40-M43 Deforming dorsopathies
0.808 0.192 0.000
Z35 Supervision of high-risk pregnancy
0.808 0.192 0.000
E13 Other specified diabetes mellitus
0.807 0.193 0.000
M25.3 Other instability of joint
0.805 0.195 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.805 0.195 0.000
I24.8 Other forms of acute ischaemic heart disease
0.805 0.195 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.803 0.197 0.000
Z96 Presence of other functional implants
0.803 0.197 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.801 0.199 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.800 0.200 0.000
I05-I09 Chronic rheumatic heart diseases
0.799 0.201 0.000
G62 Other polyneuropathies
0.799 0.201 0.000
I30 Acute pericarditis
0.799 0.201 0.000
M33 Dermatopolymyositis
0.799 0.201 0.000
G95 Other diseases of spinal cord
0.798 0.202 0.000
H65 Nonsuppurative otitis media
0.798 0.202 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.796 0.204 0.000
Y00-Y09 Assault
0.795 0.205 0.000
S00 Superficial injury of head
0.794 0.206 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.793 0.207 0.000
Y57 Other and unspecified drugs and medicaments
0.792 0.208 0.000
H74 Other disorders of middle ear and mastoid
0.791 0.209 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.790 0.210 0.000
Z36 Antenatal screening
0.789 0.211 0.000
E14.3 With ophthalmic complications
0.788 0.212 0.000
Z57.2 Occupational exposure to dust
0.786 0.214 0.000
Chapter XXII Codes for special purposes
0.785 0.215 0.000
M06 Other rheumatoid arthritis
0.784 0.216 0.000
Y52 Agents primarily affecting the cardiovascular system
0.783 0.217 0.000
H90 Conductive and sensorineural hearing loss
0.783 0.217 0.000
Z31 Procreative management
0.783 0.217 0.000
R59.0 Localised enlarged lymph nodes
0.783 0.217 0.000
M11 Other crystal arthropathies
0.780 0.220 0.000
Z57.3 Occupational exposure to other air contaminants
0.780 0.220 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.780 0.220 0.000
Z57.5 Occupational exposure to toxic agents in other industries
0.777 0.223 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.777 0.223 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.776 0.224 0.000
S32 Fracture of lumbar spine and pelvis
0.776 0.224 0.000
G82 Paraplegia and tetraplegia
0.774 0.226 0.000
I44 Atrioventricular and left bundle-branch block
0.773 0.227 0.000
M05 Seropositive rheumatoid arthritis
0.772 0.228 0.000
M65 Synovitis and tenosynovitis
0.771 0.229 0.000
R52 Pain, not elsewhere classified
0.771 0.229 0.000
J09-J18 Influenza and pneumonia
0.771 0.229 0.000
T85.2 Mechanical complication of intraocular lens
0.770 0.230 0.000
Z96.6 Presence of orthopaedic joint implants
0.770 0.230 0.000
E27 Other disorders of adrenal gland
0.769 0.231 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.768 0.231 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.768 0.232 0.000
R10.0 Acute abdomen
0.767 0.233 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.766 0.234 0.000
Z94 Transplanted organ and tissue status
0.766 0.234 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.765 0.235 0.000
G93 Other disorders of brain
0.763 0.237 0.000
O80 Single spontaneous delivery
0.763 0.237 0.000
F33 Recurrent depressive disorder
0.762 0.238 0.000
M24.1 Other articular cartilage disorders
0.761 0.239 0.000
J98 Other respiratory disorders
0.761 0.239 0.000
Chapter VII Diseases of the eye and adnexa
0.760 0.240 0.000
M25.78 Osteophyte (Other)
0.760 0.240 0.000
Z88.2 Personal history of allergy to sulphonamides
0.759 0.241 0.000
Z58 Problems related to physical environment
0.759 0.241 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.759 0.241 0.000
H73 Other disorders of tympanic membrane
0.759 0.241 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.758 0.242 0.000
O24 Diabetes mellitus in pregnancy
0.757 0.243 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.757 0.243 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.756 0.244 0.000
X50-X57 Overexertion, travel and privation
0.756 0.244 0.000
S00.8 Superficial injury of other parts of head
0.755 0.245 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.754 0.246 0.000
M22 Disorders of patella
0.754 0.246 0.000
M25.4 Effusion of joint
0.753 0.247 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.750 0.250 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.749 0.251 0.000
Y95 Nosocomial condition
0.749 0.251 0.000
F31 Bipolar affective disorder
0.748 0.252 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.748 0.252 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.748 0.252 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.747 0.253 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.747 0.253 0.000
M54.2 Cervicalgia
0.747 0.253 0.000
Q80-Q89 Other congenital malformations
0.744 0.256 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.744 0.256 0.000
G30-G32 Other degenerative diseases of the nervous system
0.744 0.256 0.000
Z63 Other problems related to primary support group, including family circumstances
0.744 0.256 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.744 0.256 0.000
G91 Hydrocephalus
0.742 0.258 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.741 0.259 0.000
M60-M63 Disorders of muscles
0.738 0.262 0.000
M25.9 Joint disorder, unspecified
0.737 0.263 0.000
M25.54 Pain in joint (Hand)
0.736 0.264 0.000
Z34.0 Supervision of normal first pregnancy
0.735 0.265 0.000
Z88.4 Personal history of allergy to anaesthetic agent
0.734 0.265 0.000
R45 Symptoms and signs involving emotional state
0.733 0.267 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.733 0.267 0.000
W20-W49 Exposure to inanimate mechanical forces
0.732 0.267 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.731 0.269 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.730 0.270 0.000
R82 Other abnormal findings in urine
0.730 0.270 0.000
M91-M94 Chondropathies
0.730 0.270 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.729 0.271 0.000
M21 Other acquired deformities of limbs
0.728 0.272 0.000
M25.0 Haemarthrosis
0.728 0.272 0.000
Chapter XI Diseases of the digestive system
0.727 0.273 0.000
I51.8 Other ill-defined heart diseases
0.727 0.273 0.000
G20-G26 Extrapyramidal and movement disorders
0.725 0.275 0.000
I42 Cardiomyopathy
0.725 0.275 0.000
Z74 Problems related to care-provider dependency
0.724 0.276 0.000
O82 Single delivery by Caesarean section
0.724 0.276 0.000
M54.6 Pain in thoracic spine
0.723 0.277 0.000
T66-T78 Other and unspecified effects of external causes
0.723 0.277 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.723 0.277 0.000
M34 Systemic sclerosis
0.723 0.277 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.723 0.277 0.000
M54.3 Sciatica
0.721 0.278 0.000
M46 Other inflammatory spondylopathies
0.721 0.279 0.000
M25.72 Osteophyte (Upper arm)
0.721 0.279 0.000
M80-M85 Disorders of bone density and structure
0.720 0.280 0.000
Z88.1 Personal history of allergy to other antibiotic agents
0.720 0.280 0.000
M24.0 Loose body in joint
0.720 0.280 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.720 0.280 0.000
S61 Open wound of wrist and hand
0.719 0.281 0.000
F20 Schizophrenia
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.716 0.284 0.000
R63 Symptoms and signs concerning food and fluid intake
0.716 0.284 0.000
G96 Other disorders of central nervous system
0.715 0.285 0.000
Z88.7 Personal history of allergy to serum and vaccine
0.715 0.285 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.715 0.285 0.000
Y35-Y36 Legal intervention and operations of war
0.715 0.285 0.000
Y10-Y34 Event of undetermined intent
0.715 0.285 0.000
X85-X99 Assault
0.715 0.285 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.715 0.285 0.000
X30-X39 Exposure to forces of nature
0.715 0.285 0.000
X20-X29 Contact with venomous animals and plants
0.715 0.285 0.000
X10-X19 Contact with heat and hot substances
0.715 0.285 0.000
X00-X09 Exposure to smoke, fire and flames
0.715 0.285 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.715 0.285 0.000
W75-W84 Other accidental threats to breathing
0.715 0.285 0.000
W65-W74 Accidental drowning and submersion
0.715 0.285 0.000
W50-W64 Exposure to animate mechanical forces
0.715 0.285 0.000
V98-V99 Other and unspecified transport accidents
0.715 0.285 0.000
V95-V97 Air and space transport accidents
0.715 0.285 0.000
V90-V94 Water transport accidents
0.715 0.285 0.000
V80-V89 Other land transport accidents
0.715 0.285 0.000
V70-V79 Bus occupant injured in transport accident
0.715 0.285 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.715 0.285 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.715 0.285 0.000
V40-V49 Car occupant injured in transport accident
0.715 0.285 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.715 0.285 0.000
V01-V09 Pedestrian injured in transport accident
0.715 0.285 0.000
G82.2 Paraplegia, unspecified
0.715 0.285 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.714 0.285 0.000
K02 Dental caries
0.714 0.286 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.714 0.286 0.000
R44.1 Visual hallucinations
0.713 0.287 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.713 0.287 0.000
Q00-Q07 Congenital malformations of the nervous system
0.713 0.287 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.713 0.287 0.000
M00-M03 Infectious arthropathies
0.713 0.287 0.000
I63 Cerebral infarction
0.713 0.287 0.000
T87 Complications peculiar to reattachment and amputation
0.712 0.288 0.000
Z32 Pregnancy examination and test
0.712 0.288 0.000
E12 Malnutrition-related diabetes mellitus
0.711 0.289 0.000
T79-T79 Certain early complications of trauma
0.710 0.289 0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics
0.710 0.290 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.710 0.290 0.000
S50-S59 Injuries to the elbow and forearm
0.710 0.290 0.000
I00-I02 Acute rheumatic fever
0.709 0.291 0.000
E14.8 With unspecified complications
0.709 0.291 0.000
E14.7 With multiple complications
0.709 0.291 0.000
E14.6 With other specified complications
0.709 0.291 0.000
E14.5 With peripheral circulatory complications
0.709 0.291 0.000
E14.4 With neurological complications
0.709 0.291 0.000
E14.2 Withrenal complications
0.709 0.291 0.000
E14.1 With ketoacidosis
0.709 0.291 0.000
E14.0 With coma
0.709 0.291 0.000
E11.5 With peripheral circulatory complications
0.709 0.291 0.000
M53 Other dorsopathies, not elsewhere classified
0.708 0.292 0.000
O80.0 Spontaneous vertex delivery
0.708 0.292 0.000
Z93.6 Other artificial openings of urinary tract status
0.708 0.292 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.707 0.293 0.000
S05 Injury of eye and orbit
0.706 0.294 0.000
G40-G47 Episodic and paroxysmal disorders
0.706 0.294 0.000
Z73 Problems related to life-management difficulty
0.706 0.294 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.706 0.294 0.000
R52.1 Chronic intractable pain
0.706 0.294 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.706 0.294 0.000
T83.3 Mechanical complication of intra-uterine contraceptive device
0.705 0.294 0.000
E11.3 With ophthalmic complications
0.705 0.295 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.704 0.296 0.000
M32 Systemic lupus erythematosus
0.704 0.296 0.000
M30 Polyarteritis nodosa and related conditions
0.704 0.296 0.000
M54.8 Other dorsalgia
0.704 0.296 0.000
M54.0 Panniculitis affecting regions of neck and back
0.704 0.296 0.000
G90 Disorders of autonomic nervous system
0.704 0.296 0.000
K02.9 Dental caries, unspecified
0.704 0.296 0.000
I67.2 Cerebral atherosclerosis
0.703 0.297 0.000
Z81 Family history of mental and behavioural disorders
0.702 0.298 0.000
V10-V19 Pedal cyclist injured in transport accident
0.702 0.298 0.000
E11.4 With neurological complications
0.702 0.298 0.000
R64 Cachexia
0.701 0.299 0.000
M25.2 Flail joint
0.700 0.300 0.000
M25.1 Fistula of joint
0.700 0.300 0.000
Z88.6 Personal history of allergy to analgesic agent
0.700 0.300 0.000
Z34.9 Supervision of normal pregnancy, unspecified
0.699 0.301 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.699 0.301 0.000
I38 Endocarditis, valve unspecified
0.698 0.301 0.000
E24 Cushing's syndrome
0.698 0.302 0.000
I47 Paroxysmal tachycardia
0.698 0.302 0.000
R59.1 Generalised enlarged lymph nodes
0.697 0.303 0.000
E23 Hypofunction and other disorders of pituitary gland
0.697 0.303 0.000
Y40 Systemic antibiotics
0.697 0.303 0.000
K90-K93 Other diseases of the digestive system
0.696 0.304 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.696 0.304 0.000
T91 Sequelae of injuries of neck and trunk
0.695 0.305 0.000
Z22 Carrier of infectious disease
0.694 0.306 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.693 0.307 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.693 0.307 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.693 0.307 0.000
S70 Superficial injury of hip and thigh
0.693 0.307 0.000
M06.9 Rheumatoid arthritis, unspecified
0.693 0.307 0.000
W00-W19 Falls
0.693 0.307 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.692 0.308 0.000
Q50-Q56 Congenital malformations of genital organs
0.692 0.308 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.692 0.308 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.692 0.308 0.000
I52 Other heart disorders in diseases classified elsewhere
0.692 0.308 0.000
I48 Atrial fibrillation and flutter
0.692 0.308 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.692 0.308 0.000
I41 Myocarditis in diseases classified elsewhere
0.692 0.308 0.000
I40 Acute myocarditis
0.692 0.308 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.692 0.308 0.000
I37 Pulmonary valve disorders
0.692 0.308 0.000
I36 Nonrheumatic tricuspid valve disorders
0.692 0.308 0.000
I32 Pericarditis in diseases classified elsewhere
0.692 0.308 0.000
E34 Other endocrine disorders
0.691 0.309 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.691 0.309 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.690 0.310 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.690 0.310 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.689 0.311 0.000
J90-J94 Other diseases of pleura
0.689 0.311 0.000
G62.9 Polyneuropathy, unspecified
0.688 0.312 0.000
M11.2 Other chondrocalcinosis
0.687 0.313 0.000
Y84.1 Kidney dialysis
0.687 0.313 0.000
O00-O08 Pregnancy with abortive outcome
0.687 0.313 0.000
Z65 Problems related to other psychosocial circumstances
0.686 0.313 0.000
Z64 Problems related to certain psychosocial circumstances
0.686 0.313 0.000
Z62 Other problems related to upbringing
0.686 0.313 0.000
Z61 Problems related to negative life events in childhood
0.686 0.313 0.000
Z59 Problems related to housing and economic circumstances
0.686 0.313 0.000
Z56 Problems related to employment and unemployment
0.686 0.313 0.000
Z55 Problems related to education and literacy
0.686 0.313 0.000
E40-E46 Malnutrition
0.686 0.314 0.000
Z35.1 Supervision of pregnancy with history of abortive outcome
0.686 0.314 0.000
G60 Hereditary and idiopathic neuropathy
0.686 0.314 0.000
O23 Infections of genito-urinary tract in pregnancy
0.686 0.314 0.000
S90-S99 Injuries to the ankle and foot
0.686 0.314 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.685 0.315 0.000
M54.56 Low back pain (Lumbar region)
0.684 0.316 0.000
Z60 Problems related to social environment
0.684 0.316 0.000
Y44 Agents primarily affecting blood constituents
0.684 0.316 0.000
M66 Spontaneous rupture of synovium and tendon
0.684 0.316 0.000
M86-M90 Other osteopathies
0.684 0.316 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.684 0.316 0.000
I62 Other nontraumatic intracranial haemorrhage
0.683 0.317 0.000
G95.8 Other specified diseases of spinal cord
0.683 0.317 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.683 0.317 0.000
M51.3 Other specified intervertebral disk degeneration
0.683 0.317 0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy
0.683 0.317 0.000
M51.9 Intervertebral disk disorder, unspecified
0.683 0.317 0.000
M51.8 Other specified intervertebral disk disorders
0.683 0.317 0.000
M51.4 Schmorl's nodes
0.683 0.317 0.000
M54.50 Low back pain (Multiple sites in spine)
0.683 0.317 0.000
Z34.8 Supervision of other normal pregnancy
0.683 0.317 0.000
Z89 Acquired absence of limb
0.683 0.317 0.000
O21 Excessive vomiting in pregnancy
0.682 0.317 0.000
T86 Failure and rejection of transplanted organs and tissues
0.681 0.319 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.681 0.319 0.000
Y59 Other and unspecified vaccines and biological substances
0.681 0.319 0.000
Y58 Bacterial vaccines
0.681 0.319 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.681 0.319 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.681 0.319 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.681 0.319 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.681 0.319 0.000
Y48 Anaesthetics and therapeutic gases
0.681 0.319 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.681 0.319 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.681 0.319 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.681 0.319 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.681 0.319 0.000
K08 Other disorders of teeth and supporting structures
0.681 0.319 0.000
O20 Haemorrhage in early pregnancy
0.681 0.319 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.680 0.320 0.000
M25.56 Pain in joint (Lower leg)
0.680 0.320 0.000
M25.8 Other specified joint disorders
0.680 0.320 0.000
S72 Fracture of femur
0.680 0.320 0.000
M07 Psoriatic and enteropathic arthropathies
0.680 0.320 0.000
R26 Abnormalities of gait and mobility
0.679 0.321 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.679 0.321 0.000
Y57.9 Drug or medicament, unspecified
0.678 0.322 0.000
O85-O92 Complications predominantly related to the puerperium
0.678 0.322 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.677 0.323 0.000
Q60-Q64 Congenital malformations of the urinary system
0.676 0.323 0.000
Y84.9 Medical procedure, unspecified
0.676 0.324 0.000
Y84.7 Blood-sampling
0.676 0.324 0.000
Y84.5 Insertion of gastric or duodenal sound
0.676 0.324 0.000
Y84.4 Aspiration of fluid
0.676 0.324 0.000
Y84.3 Shock therapy
0.676 0.324 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.676 0.324 0.000
M54.49 Lumbago with sciatica (Site unspecified)
0.676 0.324 0.000
M25.79 Osteophyte (Site unspecified)
0.675 0.325 0.000
M25.73 Osteophyte (Forearm)
0.675 0.325 0.000
M25.71 Osteophyte (Shoulder region)
0.675 0.325 0.000
M25.70 Osteophyte (Multiple sites)
0.675 0.325 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.675 0.325 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.675 0.325 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.675 0.325 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.675 0.325 0.000
E13.9 Without complications
0.675 0.325 0.000
R80 Isolated proteinuria
0.673 0.326 0.000
S43.0 Dislocation of shoulder joint
0.673 0.327 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.672 0.328 0.000
Z84 Family history of other conditions
0.672 0.328 0.000
G70-G73 Diseases of myoneural junction and muscle
0.672 0.328 0.000
Z75 Problems related to medical facilities and other health care
0.672 0.328 0.000
Z97 Presence of other devices
0.672 0.328 0.000
M67 Other disorders of synovium and tendon
0.671 0.329 0.000
X60-X84 Intentional self-harm
0.670 0.329 0.000
R57 Shock, not elsewhere classified
0.670 0.330 0.000
R58 Haemorrhage, not elsewhere classified
0.670 0.330 0.000
E16 Other disorders of pancreatic internal secretion
0.670 0.330 0.000
I67.9 Cerebrovascular disease, unspecified
0.670 0.330 0.000
Z38 Liveborn infants according to place of birth
0.669 0.331 0.000
F33.9 Recurrent depressive disorder, unspecified
0.669 0.331 0.000
H90.2 Conductive hearing loss, unspecified
0.668 0.332 0.000
E29 Testicular dysfunction
0.668 0.332 0.000
Z94.0 Kidney transplant status
0.668 0.332 0.000
I44.7 Left bundle-branch block, unspecified
0.667 0.333 0.000
M54.1 Radiculopathy
0.667 0.333 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.667 0.333 0.000
M33.1 Other dermatomyositis
0.667 0.333 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.667 0.333 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.667 0.333 0.000
Q35-Q37 Cleft lip and cleft palate
0.667 0.333 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.667 0.333 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.665 0.334 0.000
H60-H62 Diseases of external ear
0.665 0.335 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.665 0.335 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.665 0.335 0.000
G92 Toxic encephalopathy
0.665 0.335 0.000
Z93.4 Other artificial openings of gastro-intestinal tract status
0.665 0.335 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.664 0.336 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.663 0.336 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.663 0.337 0.000
H70 Mastoiditis and related conditions
0.663 0.337 0.000
H69 Other disorders of Eustachian tube
0.663 0.337 0.000
H68 Eustachian salpingitis and obstruction
0.663 0.337 0.000
H67 Otitis media in diseases classified elsewhere
0.663 0.337 0.000
I22 Subsequent myocardial infarction
0.663 0.337 0.000
Z35.5 Supervision of elderly primigravida
0.663 0.337 0.000
R41.3 Other amnesia
0.662 0.338 0.000
Z36.2 Other antenatal screening based on amniocentesis
0.661 0.339 0.000
M22.2 Patellofemoral disorders
0.660 0.340 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.660 0.340 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.660 0.340 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.660 0.340 0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.660 0.340 0.000
M54.92 Dorsalgia, unspecified (Cervical region)
0.660 0.340 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.660 0.340 0.000
Z40 Prophylactic surgery
0.660 0.340 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.659 0.340 0.000
Y84.8 Other medical procedures
0.659 0.340 0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft
0.659 0.341 0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract
0.659 0.341 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.659 0.341 0.000
T83.2 Mechanical complication of graft of urinary organ
0.659 0.341 0.000
Z31.4 Procreative investigation and testing
0.658 0.342 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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