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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs78574971
log Bayes Factor = 12.9395
Chromosome 12   position 52,023,925  (GRCh37) Explore rs78574971 on Ensembl!
Variant rs78574971 is part of Cluster X0032

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.999 0.001 0.000
I30-I52 Other forms of heart disease
0.998 0.002 0.000
E65-E68 Obesity and other hyperalimentation
0.997 0.003 0.000
E66 Obesity
0.995 0.005 0.000
M20-M25 Other joint disorders
0.994 0.006 0.000
T81 Complications of procedures, not elsewhere classified
0.994 0.006 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.989 0.011 0.000
M50-M54 Other dorsopathies
0.988 0.012 0.000
M25 Other joint disorders, not elsewhere classified
0.988 0.012 0.000
Chapter XX External causes of morbidity and mortality
0.988 0.012 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.982 0.018 0.000
E66.9 Obesity, unspecified
0.982 0.018 0.000
Chapter XI Diseases of the digestive system
0.982 0.018 0.000
M54 Dorsalgia
0.982 0.018 0.000
E00-E07 Disorders of thyroid gland
0.982 0.018 0.000
I51 Complications and ill-defined descriptions of heart disease
0.978 0.022 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.974 0.026 0.000
I47 Paroxysmal tachycardia
0.968 0.032 0.000
K13 Other diseases of lip and oral mucosa
0.966 0.034 0.000
E66.8 Other obesity
0.965 0.035 0.000
M25.5 Pain in joint
0.961 0.039 0.000
M45-M49 Spondylopathies
0.959 0.041 0.000
I51.7 Cardiomegaly
0.955 0.045 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.952 0.048 0.000
E03 Other hypothyroidism
0.947 0.053 0.000
M25.56 Pain in joint (Lower leg)
0.943 0.057 0.000
I47.2 Ventricular tachycardia
0.941 0.059 0.000
K05 Gingivitis and periodontal diseases
0.938 0.062 0.000
M54.9 Dorsalgia, unspecified
0.936 0.064 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.934 0.066 0.000
K13.0 Diseases of lips
0.933 0.067 0.000
I05-I09 Chronic rheumatic heart diseases
0.933 0.067 0.000
M54.5 Low back pain
0.930 0.070 0.000
M25.7 Osteophyte
0.929 0.071 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.927 0.073 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.922 0.078 0.000
K01 Embedded and impacted teeth
0.921 0.079 0.000
Chapter X Diseases of the respiratory system
0.921 0.079 0.000
E03.9 Hypothyroidism, unspecified
0.918 0.082 0.000
K35-K38 Diseases of appendix
0.917 0.083 0.000
D70 Agranulocytosis
0.908 0.092 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.906 0.094 0.000
M40-M43 Deforming dorsopathies
0.906 0.094 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.905 0.095 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.897 0.103 0.000
K05.3 Chronic periodontitis
0.897 0.103 0.000
S80-S89 Injuries to the knee and lower leg
0.896 0.104 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.892 0.108 0.000
E10-E14 Diabetes mellitus
0.888 0.112 0.000
I08 Multiple valve diseases
0.887 0.113 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.883 0.117 0.000
J09-J18 Influenza and pneumonia
0.878 0.122 0.000
M46 Other inflammatory spondylopathies
0.878 0.122 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.875 0.125 0.000
M54.56 Low back pain (Lumbar region)
0.875 0.125 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.874 0.126 0.000
M54.4 Lumbago with sciatica
0.874 0.126 0.000
M25.76 Osteophyte (Lower leg)
0.873 0.127 0.000
I87 Other disorders of veins
0.869 0.131 0.000
J00-J06 Acute upper respiratory infections
0.867 0.133 0.000
K14 Diseases of tongue
0.867 0.133 0.000
I44 Atrioventricular and left bundle-branch block
0.864 0.136 0.000
K35 Acute appendicitis
0.857 0.143 0.000
M24 Other specific joint derangements
0.853 0.147 0.000
S90-S99 Injuries to the ankle and foot
0.850 0.150 0.000
D80-D89 Certain disorders involving the immune mechanism
0.848 0.152 0.000
M41 Scoliosis
0.844 0.156 0.000
K70-K77 Diseases of liver
0.843 0.157 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.840 0.160 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.838 0.162 0.000
D72 Other disorders of white blood cells
0.837 0.163 0.000
S82 Fracture of lower leg, including ankle
0.836 0.164 0.000
K01.1 Impacted teeth
0.836 0.164 0.000
E10 Insulin-dependent diabetes mellitus
0.835 0.165 0.000
I31 Other diseases of pericardium
0.833 0.167 0.000
M80-M85 Disorders of bone density and structure
0.830 0.170 0.000
M47 Spondylosis
0.828 0.172 0.000
I08.0 Disorders of both mitral and aortic valves
0.825 0.175 0.000
W00-W19 Falls
0.823 0.177 0.000
Chapter XXII Codes for special purposes
0.822 0.178 0.000
I34 Nonrheumatic mitral valve disorders
0.820 0.180 0.000
I45 Other conduction disorders
0.820 0.180 0.000
M21 Other acquired deformities of limbs
0.820 0.180 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.820 0.180 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.818 0.182 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.817 0.183 0.000
Chapter VIII Diseases of the ear and mastoid process
0.817 0.183 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.815 0.185 0.000
E70-E90 Metabolic disorders
0.814 0.186 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.813 0.187 0.000
M25.9 Joint disorder, unspecified
0.813 0.187 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.811 0.189 0.000
M05-M14 Inflammatory polyarthropathies
0.808 0.192 0.000
J18 Pneumonia, organism unspecified
0.807 0.193 0.000
E20-E35 Disorders of other endocrine glands
0.802 0.198 0.000
K09 Cysts of oral region, not elsewhere classified
0.802 0.198 0.000
M41.9 Scoliosis, unspecified
0.800 0.200 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.799 0.201 0.000
M31 Other necrotising vasculopathies
0.797 0.203 0.000
Chapter VI Diseases of the nervous system
0.795 0.205 0.000
K14.0 Glossitis
0.795 0.205 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.794 0.206 0.000
I51.9 Heart disease, unspecified
0.793 0.207 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.793 0.207 0.000
J06 Acute upper respiratory infections of multiple and unspecified sites
0.792 0.208 0.000
E04 Other non-toxic goitre
0.792 0.208 0.000
J18.1 Lobar pneumonia, unspecified
0.791 0.209 0.000
S32 Fracture of lumbar spine and pelvis
0.791 0.209 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.790 0.210 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.790 0.210 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.790 0.210 0.000
T87 Complications peculiar to reattachment and amputation
0.790 0.210 0.000
M25.50 Pain in joint (Multiple sites)
0.787 0.213 0.000
M54.59 Low back pain (Site unspecified)
0.787 0.213 0.000
K01.0 Embedded teeth
0.785 0.215 0.000
K13.6 Irritative hyperplasia of oral mucosa
0.783 0.216 0.000
I95 Hypotension
0.782 0.218 0.000
E07 Other disorders of thyroid
0.781 0.219 0.000
S10-S19 Injuries to the neck
0.781 0.219 0.000
E10.9 Without complications
0.780 0.220 0.000
V40-V49 Car occupant injured in transport accident
0.779 0.221 0.000
E83 Disorders of mineral metabolism
0.779 0.221 0.000
I33 Acute and subacute endocarditis
0.779 0.221 0.000
M25.53 Pain in joint (Forearm)
0.778 0.222 0.000
I51.6 Cardiovascular disease, unspecified
0.778 0.222 0.000
T90 Sequelae of injuries of head
0.777 0.223 0.000
S60-S69 Injuries to the wrist and hand
0.776 0.224 0.000
S82.4 Fracture of fibula alone
0.774 0.226 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.774 0.226 0.000
K35.0 Acute appendicitis with generalised peritonitis
0.772 0.228 0.000
I77 Other disorders of arteries and arterioles
0.771 0.229 0.000
M41.96 Scoliosis, unspecified (Lumbar region)
0.770 0.230 0.000
K13.7 Other and unspecified lesions of oral mucosa
0.766 0.234 0.000
M25.0 Haemarthrosis
0.766 0.234 0.000
I95.9 Hypotension, unspecified
0.764 0.236 0.000
M53 Other dorsopathies, not elsewhere classified
0.762 0.237 0.000
D86 Sarcoidosis
0.762 0.238 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.761 0.239 0.000
W50-W64 Exposure to animate mechanical forces
0.760 0.240 0.000
K13.4 Granuloma and granuloma-like lesions of oral mucosa
0.759 0.240 0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)
0.759 0.241 0.000
K10 Other diseases of jaws
0.758 0.242 0.000
K11 Diseases of salivary glands
0.757 0.243 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.756 0.244 0.000
I87.8 Other specified disorders of veins
0.755 0.245 0.000
D72.8 Other specified disorders of white blood cells
0.755 0.245 0.000
K38 Other diseases of appendix
0.754 0.246 0.000
M34 Systemic sclerosis
0.754 0.246 0.000
X50-X57 Overexertion, travel and privation
0.754 0.246 0.000
I87.2 Venous insufficiency (chronic) (peripheral)
0.753 0.247 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.753 0.247 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.753 0.247 0.000
I49 Other cardiac arrhythmias
0.752 0.248 0.000
I86 Varicose veins of other sites
0.751 0.248 0.000
M00-M03 Infectious arthropathies
0.750 0.250 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.750 0.250 0.000
I87.1 Compression of vein
0.748 0.252 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.745 0.255 0.000
I42 Cardiomyopathy
0.745 0.255 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.743 0.257 0.000
M35 Other systemic involvement of connective tissue
0.743 0.257 0.000
M91-M94 Chondropathies
0.742 0.258 0.000
M25.78 Osteophyte (Other)
0.742 0.258 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.741 0.259 0.000
K75 Other inflammatory liver diseases
0.740 0.260 0.000
V80-V89 Other land transport accidents
0.740 0.260 0.000
E83.1 Disorders of iron metabolism
0.739 0.261 0.000
J06.9 Acute upper respiratory infection, unspecified
0.739 0.261 0.000
M54.47 Lumbago with sciatica (Lumbosacral region)
0.739 0.261 0.000
D73 Diseases of spleen
0.739 0.261 0.000
S92 Fracture of foot, except ankle
0.738 0.262 0.000
S89 Other and unspecified injuries of lower leg
0.738 0.262 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.738 0.262 0.000
I20-I25 Ischaemic heart diseases
0.736 0.264 0.000
I31.9 Disease of pericardium, unspecified
0.736 0.264 0.000
T86 Failure and rejection of transplanted organs and tissues
0.735 0.265 0.000
J95-J99 Other diseases of the respiratory system
0.734 0.266 0.000
J10 Influenza due to identified influenza virus
0.732 0.268 0.000
K05.6 Periodontal disease, unspecified
0.732 0.268 0.000
M54.46 Lumbago with sciatica (Lumbar region)
0.732 0.268 0.000
M48 Other spondylopathies
0.729 0.270 0.000
S82.40 Fracture of fibula alone (closed)
0.729 0.271 0.000
M54.55 Low back pain (Thoracolumbar region)
0.729 0.271 0.000
E06 Thyroiditis
0.726 0.274 0.000
M54.3 Sciatica
0.726 0.274 0.000
I85 Oesophageal varices
0.726 0.274 0.000
K35.1 Acute appendicitis with peritoneal abscess
0.726 0.274 0.000
I77.6 Arteritis, unspecified
0.726 0.274 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.725 0.275 0.000
M25.8 Other specified joint disorders
0.724 0.276 0.000
M21.0 Valgus deformity, not elsewhere classified
0.724 0.276 0.000
M24.0 Loose body in joint
0.724 0.276 0.000
M50 Cervical disk disorders
0.722 0.278 0.000
X60-X84 Intentional self-harm
0.722 0.278 0.000
M47.8 Other spondylosis
0.721 0.279 0.000
M22 Disorders of patella
0.721 0.279 0.000
M25.54 Pain in joint (Hand)
0.720 0.279 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.720 0.280 0.000
I20 Angina pectoris
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
I44.0 Atrioventricular block, first degree
0.717 0.283 0.000
Chapter I Certain infectious and parasitic diseases
0.716 0.284 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.716 0.284 0.000
I52 Other heart disorders in diseases classified elsewhere
0.716 0.284 0.000
I48 Atrial fibrillation and flutter
0.716 0.284 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.716 0.284 0.000
I41 Myocarditis in diseases classified elsewhere
0.716 0.284 0.000
I40 Acute myocarditis
0.716 0.284 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.716 0.284 0.000
I37 Pulmonary valve disorders
0.716 0.284 0.000
I36 Nonrheumatic tricuspid valve disorders
0.716 0.284 0.000
I32 Pericarditis in diseases classified elsewhere
0.716 0.284 0.000
M45 Ankylosing spondylitis
0.716 0.284 0.000
E50-E64 Other nutritional deficiencies
0.716 0.284 0.000
E67 Other hyperalimentation
0.715 0.285 0.000
E68 Sequelae of hyperalimentation
0.715 0.285 0.000
E65 Localised adiposity
0.715 0.285 0.000
K12 Stomatitis and related lesions
0.715 0.285 0.000
M54.2 Cervicalgia
0.714 0.286 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.713 0.286 0.000
E66.1 Drug-induced obesity
0.713 0.286 0.000
E66.0 Obesity due to excess calories
0.713 0.286 0.000
X20-X29 Contact with venomous animals and plants
0.713 0.287 0.000
T93 Sequelae of injuries of lower limb
0.713 0.287 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.713 0.287 0.000
M33 Dermatopolymyositis
0.713 0.287 0.000
M32 Systemic lupus erythematosus
0.713 0.287 0.000
M30 Polyarteritis nodosa and related conditions
0.713 0.287 0.000
J00 Acute nasopharyngitis [common cold]
0.713 0.287 0.000
T81.9 Unspecified complication of procedure
0.712 0.287 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.712 0.287 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.712 0.287 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.712 0.287 0.000
E03.8 Other specified hypothyroidism
0.712 0.288 0.000
S00-S09 Injuries to the head
0.711 0.289 0.000
E14 Unspecified diabetes mellitus
0.710 0.290 0.000
W20-W49 Exposure to inanimate mechanical forces
0.710 0.290 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.709 0.291 0.000
M25.3 Other instability of joint
0.709 0.291 0.000
M25.2 Flail joint
0.709 0.291 0.000
M25.1 Fistula of joint
0.709 0.291 0.000
Y35-Y36 Legal intervention and operations of war
0.709 0.291 0.000
Y10-Y34 Event of undetermined intent
0.709 0.291 0.000
Y00-Y09 Assault
0.709 0.291 0.000
X85-X99 Assault
0.709 0.291 0.000
X30-X39 Exposure to forces of nature
0.709 0.291 0.000
X10-X19 Contact with heat and hot substances
0.709 0.291 0.000
X00-X09 Exposure to smoke, fire and flames
0.709 0.291 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.709 0.291 0.000
W75-W84 Other accidental threats to breathing
0.709 0.291 0.000
W65-W74 Accidental drowning and submersion
0.709 0.291 0.000
V98-V99 Other and unspecified transport accidents
0.709 0.291 0.000
V95-V97 Air and space transport accidents
0.709 0.291 0.000
V90-V94 Water transport accidents
0.709 0.291 0.000
V70-V79 Bus occupant injured in transport accident
0.709 0.291 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.709 0.291 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.709 0.291 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.709 0.291 0.000
V01-V09 Pedestrian injured in transport accident
0.709 0.291 0.000
V10-V19 Pedal cyclist injured in transport accident
0.707 0.293 0.000
I99 Other and unspecified disorders of circulatory system
0.707 0.293 0.000
Q60-Q64 Congenital malformations of the urinary system
0.705 0.295 0.000
W19 Unspecified fall
0.705 0.295 0.000
K03 Other diseases of hard tissues of teeth
0.704 0.296 0.000
M54.8 Other dorsalgia
0.704 0.296 0.000
M54.0 Panniculitis affecting regions of neck and back
0.704 0.296 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.704 0.296 0.000
E00 Congenital iodine-deficiency syndrome
0.704 0.296 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.704 0.296 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.704 0.296 0.000
K65-K67 Diseases of peritoneum
0.702 0.298 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.702 0.298 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.701 0.298 0.000
I51.5 Myocardial degeneration
0.701 0.299 0.000
I51.4 Myocarditis, unspecified
0.701 0.299 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.701 0.299 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.701 0.299 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.701 0.299 0.000
I51.0 Cardiac septal defect, acquired
0.701 0.299 0.000
I34.0 Mitral (valve) insufficiency
0.701 0.299 0.000
J81 Pulmonary oedema
0.699 0.301 0.000
D55-D59 Haemolytic anaemias
0.698 0.302 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.698 0.302 0.000
S82.5 Fracture of medial malleolus
0.697 0.302 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.696 0.304 0.000
S82.0 Fracture of patella
0.696 0.304 0.000
I47.0 Reentry ventricular arrhythmia
0.694 0.306 0.000
I82 Other venous embolism and thrombosis
0.693 0.306 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.693 0.307 0.000
K13.2 Leukoplakia and other disturbances of oral epithelium, including tongue
0.692 0.307 0.000
K13.5 Oral submucous fibrosis
0.692 0.307 0.000
K13.3 Hairy leukoplakia
0.692 0.307 0.000
K13.1 Cheek and lip biting
0.692 0.307 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.692 0.308 0.000
J01 Acute sinusitis
0.692 0.308 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.691 0.309 0.000
M05 Seropositive rheumatoid arthritis
0.691 0.309 0.000
I44.2 Atrioventricular block, complete
0.691 0.309 0.000
M25.59 Pain in joint (Site unspecified)
0.689 0.311 0.000
M25.58 Pain in joint (Other)
0.689 0.311 0.000
M25.52 Pain in joint (Upper arm)
0.689 0.311 0.000
M54.50 Low back pain (Multiple sites in spine)
0.689 0.311 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.689 0.311 0.000
H90-H95 Other disorders of ear
0.689 0.311 0.000
T79-T79 Certain early complications of trauma
0.689 0.311 0.000
Q00-Q07 Congenital malformations of the nervous system
0.688 0.312 0.000
M49 Spondylopathies in diseases classified elsewhere
0.687 0.313 0.000
E10.1 With ketoacidosis
0.687 0.313 0.000
M25.96 Joint disorder, unspecified (Lower leg)
0.687 0.313 0.000
T83.3 Mechanical complication of intra-uterine contraceptive device
0.686 0.314 0.000
K00 Disorders of tooth development and eruption
0.685 0.315 0.000
E88 Other metabolic disorders
0.684 0.316 0.000
T92 Sequelae of injuries of upper limb
0.684 0.316 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.682 0.317 0.000
D74 Methaemoglobinaemia
0.682 0.317 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.682 0.317 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.682 0.317 0.000
T23 Burn and corrosion of wrist and hand
0.682 0.318 0.000
M54.6 Pain in thoracic spine
0.681 0.318 0.000
S20-S29 Injuries to the thorax
0.681 0.319 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.681 0.319 0.000
M86-M90 Other osteopathies
0.681 0.319 0.000
M80 Osteoporosis with pathological fracture
0.680 0.320 0.000
M31.3 Wegener's granulomatosis
0.680 0.320 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.680 0.320 0.000
M25.57 Pain in joint (Ankle and foot)
0.679 0.321 0.000
E03.5 Myxoedema coma
0.679 0.321 0.000
E03.4 Atrophy of thyroid (acquired)
0.679 0.321 0.000
E03.3 Postinfectious hypothyroidism
0.679 0.321 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.679 0.321 0.000
E03.1 Congenital hypothyroidism without goitre
0.679 0.321 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.679 0.321 0.000
S82.3 Fracture of lower end of tibia
0.679 0.321 0.000
M47.82 Other spondylosis (Cervical region)
0.677 0.323 0.000
I81 Portal vein thrombosis
0.677 0.323 0.000
K74 Fibrosis and cirrhosis of liver
0.677 0.323 0.000
I07 Rheumatic tricuspid valve diseases
0.676 0.323 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.676 0.324 0.000
S32.4 Fracture of acetabulum
0.675 0.324 0.000
T66-T78 Other and unspecified effects of external causes
0.675 0.325 0.000
M70-M79 Other soft tissue disorders
0.674 0.326 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.673 0.327 0.000
K05.2 Acute periodontitis
0.672 0.327 0.000
K05.5 Other periodontal diseases
0.672 0.327 0.000
K05.4 Periodontosis
0.672 0.327 0.000
K05.1 Chronic gingivitis
0.672 0.327 0.000
K05.0 Acute gingivitis
0.672 0.327 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.672 0.328 0.000
M65-M68 Disorders of synovium and tendon
0.671 0.328 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.671 0.329 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.671 0.329 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.671 0.329 0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.671 0.329 0.000
M54.92 Dorsalgia, unspecified (Cervical region)
0.671 0.329 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.671 0.329 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.671 0.329 0.000
Y65 Other misadventures during surgical and medical care
0.670 0.330 0.000
I09 Other rheumatic heart diseases
0.669 0.331 0.000
I06 Rheumatic aortic valve diseases
0.669 0.331 0.000
E40-E46 Malnutrition
0.668 0.332 0.000
D75 Other diseases of blood and blood-forming organs
0.668 0.332 0.000
I44.7 Left bundle-branch block, unspecified
0.668 0.332 0.000
M54.54 Low back pain-Thoracic
0.667 0.333 0.000
M54.53 Low back pain-Cervicothoracic
0.667 0.333 0.000
M54.52 Low back pain-Cervical
0.667 0.333 0.000
M54.51 Low back pain-Occipit-atl-axl
0.667 0.333 0.000
I45.3 Trifascicular block
0.666 0.333 0.000
M25.79 Osteophyte (Site unspecified)
0.666 0.334 0.000
M25.73 Osteophyte (Forearm)
0.666 0.334 0.000
M25.72 Osteophyte (Upper arm)
0.666 0.334 0.000
M25.70 Osteophyte (Multiple sites)
0.666 0.334 0.000
J03 Acute tonsillitis
0.665 0.335 0.000
I30 Acute pericarditis
0.664 0.336 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.664 0.336 0.000
S37 Injury of urinary and pelvic organs
0.664 0.336 0.000
S36 Injury of intra-abdominal organs
0.664 0.336 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.664 0.336 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.664 0.336 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.664 0.336 0.000
S31 Open wound of abdomen, lower back and pelvis
0.664 0.336 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.663 0.337 0.000
K72 Hepatic failure, not elsewhere classified
0.663 0.337 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.663 0.337 0.000
M84 Disorders of continuity of bone
0.663 0.337 0.000
J60-J70 Lung diseases due to external agents
0.662 0.338 0.000
Y89 Sequelae of other external causes
0.662 0.338 0.000
I84 Haemorrhoids
0.662 0.338 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.661 0.339 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.661 0.339 0.000
T82.3 Mechanical complication of other vascular grafts
0.661 0.339 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.661 0.339 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.661 0.339 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.661 0.339 0.000
G90-G99 Other disorders of the nervous system
0.658 0.342 0.000
K36 Other appendicitis
0.657 0.343 0.000
K35.8 Acute appendicitis, other and unspecified
0.657 0.343 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.656 0.344 0.000
S30.1 Contusion of abdominal wall
0.655 0.345 0.000
I05 Rheumatic mitral valve diseases
0.654 0.346 0.000
V20-V29 Motorcycle rider injured in transport accident
0.653 0.347 0.000
S81 Open wound of lower leg
0.653 0.347 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.653 0.347 0.000
K09.0 Developmental odontogenic cysts
0.653 0.347 0.000
Y88 Sequelae of surgical and medical care as external cause
0.652 0.347 0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)
0.652 0.348 0.000
I84.6 Residual haemorrhoidal skin tags
0.652 0.348 0.000
M85 Other disorders of bone density and structure
0.650 0.350 0.000
E04.2 Non-toxic multinodular goitre
0.650 0.350 0.000
I88 Nonspecific lymphadenitis
0.649 0.350 0.000
M42 Spinal osteochondrosis
0.649 0.350 0.000
M40 Kyphosis and lordosis
0.649 0.350 0.000
G40-G47 Episodic and paroxysmal disorders
0.649 0.351 0.000
Q80-Q89 Other congenital malformations
0.649 0.351 0.000
T98 Sequelae of other and unspecified effects of external causes
0.648 0.351 0.000
T95 Sequelae of burns, corrosions and frostbite
0.648 0.351 0.000
T91 Sequelae of injuries of neck and trunk
0.648 0.351 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.648 0.351 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.648 0.351 0.000
Y79 Orthopaedic devices associated with adverse incidents
0.648 0.351 0.000
E74 Other disorders of carbohydrate metabolism
0.648 0.352 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.648 0.352 0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.648 0.352 0.000
E14.9 Without complications
0.647 0.353 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.646 0.354 0.000
E13 Other specified diabetes mellitus
0.646 0.354 0.000
D60-D64 Aplastic and other anaemias
0.645 0.355 0.000
Y52 Agents primarily affecting the cardiovascular system
0.645 0.355 0.000
S61 Open wound of wrist and hand
0.644 0.356 0.000
M06 Other rheumatoid arthritis
0.644 0.356 0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft
0.643 0.357 0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract
0.643 0.357 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.643 0.357 0.000
T83.2 Mechanical complication of graft of urinary organ
0.643 0.357 0.000
I74 Arterial embolism and thrombosis
0.642 0.358 0.000
S88 Traumatic amputation of lower leg
0.642 0.358 0.000
S87 Crushing injury of lower leg
0.642 0.358 0.000
S86 Injury of muscle and tendon at lower leg level
0.642 0.358 0.000
S85 Injury of blood vessels at lower leg level
0.642 0.358 0.000
S84 Injury of nerves at lower leg level
0.642 0.358 0.000
S40-S49 Injuries to the shoulder and upper arm
0.642 0.358 0.000
M47.1 Other spondylosis with myelopathy
0.642 0.358 0.000
I20.0 Unstable angina
0.640 0.360 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.640 0.360 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.639 0.361 0.000
T87.6 Other and unspecified complications of amputation stump
0.639 0.361 0.000
W18 Other fall on same level
0.639 0.361 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.638 0.362 0.000
M24.5 Contracture of joint
0.638 0.362 0.000
E07.9 Disorder of thyroid, unspecified
0.638 0.362 0.000
K38.8 Other specified diseases of appendix
0.638 0.362 0.000
E12 Malnutrition-related diabetes mellitus
0.637 0.363 0.000
I47.1 Supraventricular tachycardia
0.637 0.363 0.000
I08.9 Multiple valve disease, unspecified
0.636 0.364 0.000
I08.8 Other multiple valve diseases
0.636 0.364 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.636 0.364 0.000
T90.5 Sequelae of intracranial injury
0.635 0.365 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.635 0.365 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.635 0.365 0.000
M11 Other crystal arthropathies
0.635 0.365 0.000
G62 Other polyneuropathies
0.634 0.366 0.000
Y86 Sequelae of other accidents
0.634 0.366 0.000
G47 Sleep disorders
0.634 0.366 0.000
H60-H62 Diseases of external ear
0.633 0.367 0.000
I51.8 Other ill-defined heart diseases
0.633 0.367 0.000
H65-H75 Diseases of middle ear and mastoid
0.633 0.367 0.000
Y85 Sequelae of transport accidents
0.633 0.367 0.000
K09.8 Other cysts of oral region, not elsewhere classified
0.632 0.367 0.000
T90.9 Sequelae of unspecified injury of head
0.632 0.368 0.000
S92.1 Fracture of talus
0.631 0.369 0.000
K04 Diseases of pulp and periapical tissues
0.631 0.369 0.000
I72 Other aneurysm
0.630 0.370 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.630 0.370 0.000
J17 Pneumonia in diseases classified elsewhere
0.629 0.370 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.629 0.370 0.000
J12 Viral pneumonia, not elsewhere classified
0.629 0.370 0.000
J11 Influenza, virus not identified
0.629 0.370 0.000
J14 Pneumonia due to Haemophilus influenzae
0.629 0.370 0.000
J09 Influenza due to certain identified influenza virus
0.629 0.370 0.000
M46.8 Other specified inflammatory spondylopathies
0.629 0.371 0.000
M46.5 Other infective spondylopathies
0.629 0.371 0.000
M46.4 Discitis, unspecified
0.629 0.371 0.000
M46.3 Infection of intervertebral disk (pyogenic)
0.629 0.371 0.000
M46.2 Osteomyelitis of vertebra
0.629 0.371 0.000
M46.1 Sacro-iliitis, not elsewhere classified
0.629 0.371 0.000
M46.0 Spinal enthesopathy
0.629 0.371 0.000
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)
0.629 0.371 0.000
I77.1 Stricture of artery
0.628 0.372 0.000
J10.1 Influenza with other respiratory manifestations, influenza virus identified
0.628 0.372 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.628 0.372 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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