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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs79978308
log Bayes Factor = 2.78083
Chromosome 21   position 41,020,545  (GRCh37) Explore rs79978308 on Ensembl!
Variant rs79978308 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
0.998 0.002 0.000
Chapter VII Diseases of the eye and adnexa
0.995 0.005 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.993 0.007 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.985 0.015 0.000
H25-H28 Disorders of lens
0.973 0.027 0.000
D60-D64 Aplastic and other anaemias
0.969 0.031 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.966 0.034 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.958 0.042 0.000
H30-H36 Disorders of choroid and retina
0.948 0.052 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.948 0.052 0.000
Chapter VI Diseases of the nervous system
0.946 0.054 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.946 0.054 0.000
H26 Other cataract
0.940 0.060 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.938 0.062 0.000
D63.0 Anaemia in neoplastic disease
0.911 0.089 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.910 0.090 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.907 0.093 0.000
N13 Obstructive and reflux uropathy
0.901 0.099 0.000
H26.9 Cataract, unspecified
0.900 0.100 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.899 0.101 0.000
N10-N16 Renal tubulo-interstitial diseases
0.899 0.101 0.000
M80-M85 Disorders of bone density and structure
0.898 0.102 0.000
R40 Somnolence, stupor and coma
0.892 0.108 0.000
Chapter XIV Diseases of the genitourinary system
0.891 0.109 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.888 0.112 0.000
G90-G99 Other disorders of the nervous system
0.885 0.115 0.000
M86-M90 Other osteopathies
0.884 0.116 0.000
Chapter XX External causes of morbidity and mortality
0.878 0.122 0.000
L60-L75 Disorders of skin appendages
0.876 0.124 0.000
G30-G32 Other degenerative diseases of the nervous system
0.874 0.126 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.870 0.130 0.000
N13.5 Kinking and stricture of ureter without hydronephrosis
0.866 0.134 0.000
H33 Retinal detachments and breaks
0.865 0.135 0.000
Q60-Q64 Congenital malformations of the urinary system
0.859 0.141 0.000
R41.3 Other amnesia
0.858 0.142 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.857 0.143 0.000
H53-H54 Visual disturbances and blindness
0.857 0.143 0.000
O60-O75 Complications of labour and delivery
0.855 0.145 0.000
R47-R49 Symptoms and signs involving speech and voice
0.849 0.151 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.840 0.160 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.837 0.163 0.000
H25 Senile cataract
0.830 0.170 0.000
D62 Acute posthaemorrhagic anaemia
0.827 0.173 0.000
O80-O84 Delivery
0.824 0.176 0.000
D55-D59 Haemolytic anaemias
0.820 0.180 0.000
D63.8 Anaemia in other chronic diseases classified elsewhere
0.818 0.182 0.000
H33.2 Serous retinal detachment
0.818 0.182 0.000
R41.0 Disorientation, unspecified
0.813 0.187 0.000
R26 Abnormalities of gait and mobility
0.812 0.187 0.000
L50-L54 Urticaria and erythema
0.811 0.189 0.000
G95 Other diseases of spinal cord
0.811 0.189 0.000
H35 Other retinal disorders
0.805 0.195 0.000
D73 Diseases of spleen
0.803 0.197 0.000
R40.0 Somnolence
0.803 0.197 0.000
M84 Disorders of continuity of bone
0.802 0.198 0.000
L60 Nail disorders
0.802 0.198 0.000
R40.2 Coma, unspecified
0.801 0.199 0.000
Chapter I Certain infectious and parasitic diseases
0.800 0.200 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.800 0.200 0.000
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified
0.799 0.201 0.000
H43-H45 Disorders of vitreous body and globe
0.796 0.204 0.000
N13.2 Hydronephrosis with renal and ureteral calculous obstruction
0.794 0.206 0.000
O62 Abnormalities of forces of labour
0.793 0.207 0.000
M60-M63 Disorders of muscles
0.790 0.210 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.785 0.215 0.000
M91-M94 Chondropathies
0.785 0.215 0.000
L40-L45 Papulosquamous disorders
0.784 0.216 0.000
M45-M49 Spondylopathies
0.778 0.222 0.000
D69 Purpura and other haemorrhagic conditions
0.777 0.223 0.000
H26.4 After-cataract
0.776 0.224 0.000
Q50-Q56 Congenital malformations of genital organs
0.775 0.225 0.000
R47 Speech disturbances, not elsewhere classified
0.774 0.226 0.000
M20-M25 Other joint disorders
0.774 0.226 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.773 0.227 0.000
N11 Chronic tubulo-interstitial nephritis
0.773 0.227 0.000
N13.4 Hydroureter
0.773 0.227 0.000
L20-L30 Dermatitis and eczema
0.773 0.227 0.000
G90 Disorders of autonomic nervous system
0.772 0.228 0.000
Q61 Cystic kidney disease
0.772 0.228 0.000
M50-M54 Other dorsopathies
0.772 0.228 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.771 0.229 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.768 0.232 0.000
R25 Abnormal involuntary movements
0.767 0.233 0.000
D61 Other aplastic anaemias
0.765 0.235 0.000
N13.0 Hydronephrosis with ureteropelvic junction obstruction
0.764 0.236 0.000
H31 Other disorders of choroid
0.763 0.237 0.000
N17-N19 Renal failure
0.762 0.238 0.000
M00-M03 Infectious arthropathies
0.762 0.238 0.000
O80 Single spontaneous delivery
0.761 0.239 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.760 0.240 0.000
M40-M43 Deforming dorsopathies
0.758 0.241 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.755 0.245 0.000
H34 Retinal vascular occlusions
0.749 0.250 0.000
H26.2 Complicated cataract
0.748 0.252 0.000
Q80-Q89 Other congenital malformations
0.747 0.253 0.000
D70 Agranulocytosis
0.744 0.256 0.000
H25.0 Senile incipient cataract
0.742 0.258 0.000
R43 Disturbances of smell and taste
0.742 0.258 0.000
O85-O92 Complications predominantly related to the puerperium
0.741 0.259 0.000
M87 Osteonecrosis
0.739 0.261 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.739 0.261 0.000
R46 Symptoms and signs involving appearance and behaviour
0.736 0.264 0.000
H54 Blindness and low vision
0.734 0.266 0.000
M84.0 Malunion of fracture
0.734 0.266 0.000
R47.0 Dysphasia and aphasia
0.731 0.269 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.730 0.270 0.000
O80.9 Single spontaneous delivery, unspecified
0.729 0.271 0.000
M25 Other joint disorders, not elsewhere classified
0.729 0.271 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.729 0.271 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.729 0.271 0.000
N13.6 Pyonephrosis
0.728 0.272 0.000
M48 Other spondylopathies
0.728 0.272 0.000
Y43 Primarily systemic agents
0.727 0.273 0.000
L60.8 Other nail disorders
0.726 0.274 0.000
H55-H59 Other disorders of eye and adnexa
0.724 0.276 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.721 0.279 0.000
M82 Osteoporosis in diseases classified elsewhere
0.720 0.280 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.719 0.280 0.000
H27 Other disorders of lens
0.718 0.282 0.000
M24 Other specific joint derangements
0.717 0.283 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.716 0.284 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.716 0.284 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.715 0.285 0.000
H35.3 Degeneration of macula and posterior pole
0.714 0.286 0.000
M86 Osteomyelitis
0.714 0.286 0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid
0.711 0.289 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.711 0.289 0.000
Y52 Agents primarily affecting the cardiovascular system
0.710 0.290 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.710 0.290 0.000
M65-M68 Disorders of synovium and tendon
0.710 0.290 0.000
D69.5 Secondary thrombocytopenia
0.709 0.291 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.707 0.293 0.000
V40-V49 Car occupant injured in transport accident
0.706 0.294 0.000
M70-M79 Other soft tissue disorders
0.705 0.295 0.000
D73.0 Hyposplenism
0.705 0.295 0.000
H44 Disorders of globe
0.704 0.296 0.000
R45 Symptoms and signs involving emotional state
0.703 0.297 0.000
G30 Alzheimer's disease
0.703 0.297 0.000
R25.2 Cramp and spasm
0.703 0.297 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.698 0.302 0.000
L29 Pruritus
0.697 0.303 0.000
M85 Other disorders of bone density and structure
0.697 0.303 0.000
L43 Lichen planus
0.696 0.304 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.695 0.305 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.695 0.305 0.000
Q61.3 Polycystic kidney, unspecified
0.695 0.305 0.000
L10-L14 Bullous disorders
0.693 0.307 0.000
G95.8 Other specified diseases of spinal cord
0.692 0.308 0.000
R81 Glycosuria
0.691 0.309 0.000
N13.8 Other obstructive and reflux uropathy
0.690 0.310 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.689 0.311 0.000
H46 Optic neuritis
0.689 0.311 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.688 0.312 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.687 0.313 0.000
Q35-Q37 Cleft lip and cleft palate
0.687 0.313 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.687 0.313 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.687 0.313 0.000
Q00-Q07 Congenital malformations of the nervous system
0.687 0.313 0.000
L71 Rosacea
0.687 0.313 0.000
O66 Other obstructed labour
0.686 0.314 0.000
M84.03 Malunion of fracture (Forearm)
0.684 0.315 0.000
R82 Other abnormal findings in urine
0.684 0.316 0.000
M48.0 Spinal stenosis
0.684 0.316 0.000
N11.9 Chronic tubulo-interstitial nephritis, unspecified
0.683 0.317 0.000
O61 Failed induction of labour
0.680 0.320 0.000
L53 Other erythematous conditions
0.680 0.320 0.000
M90 Osteopathies in diseases classified elsewhere
0.680 0.320 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.680 0.320 0.000
H30 Chorioretinal inflammation
0.680 0.320 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.679 0.320 0.000
H26.0 Infantile, juvenile and presenile cataract
0.679 0.321 0.000
D63.1 Anaemia in other chronic diseases classified elsewhere
0.678 0.322 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.678 0.322 0.000
R41.2 Retrograde amnesia
0.676 0.324 0.000
O62.3 Precipitate labour
0.676 0.324 0.000
Q63 Other congenital malformations of kidney
0.676 0.324 0.000
H26.3 Drug-induced cataract
0.674 0.326 0.000
H26.1 Traumatic cataract
0.674 0.326 0.000
N19 Unspecified renal failure
0.674 0.326 0.000
L05 Pilonidal cyst
0.674 0.326 0.000
N13.3 Other and unspecified hydronephrosis
0.668 0.332 0.000
G40-G47 Episodic and paroxysmal disorders
0.667 0.333 0.000
D75 Other diseases of blood and blood-forming organs
0.666 0.334 0.000
G93 Other disorders of brain
0.664 0.336 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.664 0.336 0.000
Y43.3 Other antineoplastic drugs
0.663 0.337 0.000
M89 Other disorders of bone
0.663 0.337 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.663 0.337 0.000
H25.9 Senile cataract, unspecified
0.663 0.337 0.000
G95.9 Disease of spinal cord, unspecified
0.662 0.338 0.000
M48.02 Spinal stenosis (Cervical region)
0.661 0.339 0.000
H25.8 Other senile cataract
0.661 0.339 0.000
Y00-Y09 Assault
0.660 0.339 0.000
H53 Visual disturbances
0.660 0.340 0.000
A30-A49 Other bacterial diseases
0.660 0.340 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.659 0.341 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.659 0.341 0.000
L29.0 Pruritus ani
0.658 0.341 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.658 0.342 0.000
D59 Acquired haemolytic anaemia
0.658 0.342 0.000
H10-H13 Disorders of conjunctiva
0.657 0.343 0.000
Y57 Other and unspecified drugs and medicaments
0.657 0.343 0.000
G91 Hydrocephalus
0.655 0.345 0.000
H49 Paralytic strabismus
0.655 0.345 0.000
R80 Isolated proteinuria
0.655 0.345 0.000
H34.8 Other retinal vascular occlusions
0.654 0.346 0.000
L72 Follicular cysts of skin and subcutaneous tissue
0.654 0.346 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.653 0.347 0.000
Y83.3 Surgical operation with formation of external stoma
0.652 0.348 0.000
R41.1 Anterograde amnesia
0.650 0.350 0.000
M62 Other disorders of muscle
0.650 0.350 0.000
B25-B34 Other viral diseases
0.649 0.351 0.000
H35.0 Background retinopathy and retinal vascular changes
0.648 0.352 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.648 0.352 0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress
0.647 0.352 0.000
W50-W64 Exposure to animate mechanical forces
0.647 0.353 0.000
L60.9 Nail disorder, unspecified
0.647 0.353 0.000
N13.7 Vesicoureteral-reflux-associated uropathy
0.646 0.354 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.646 0.354 0.000
M72 Fibroblastic disorders
0.645 0.355 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.645 0.355 0.000
D74 Methaemoglobinaemia
0.645 0.355 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.645 0.355 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.645 0.355 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.644 0.355 0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere
0.644 0.356 0.000
N15 Other renal tubulo-interstitial diseases
0.644 0.356 0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
0.644 0.356 0.000
D73.5 Infarction of spleen
0.644 0.356 0.000
D66 Hereditary factor VIII deficiency
0.644 0.356 0.000
B95-B98 Bacterial, viral and other infectious agents
0.644 0.356 0.000
M83 Adult osteomalacia
0.644 0.356 0.000
O62.2 Other uterine inertia
0.643 0.357 0.000
Y83.0 Surgical operation with transplant of whole organ
0.643 0.357 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.643 0.357 0.000
V20-V29 Motorcycle rider injured in transport accident
0.643 0.357 0.000
D58 Other hereditary haemolytic anaemias
0.643 0.357 0.000
B99-B99 Other infectious diseases
0.642 0.358 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.642 0.358 0.000
R50-R69 General symptoms and signs
0.642 0.358 0.000
R26.3 Immobility
0.641 0.359 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.641 0.359 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.640 0.360 0.000
R40.1 Stupor
0.640 0.360 0.000
L81 Other disorders of pigmentation
0.639 0.361 0.000
M25.5 Pain in joint
0.638 0.362 0.000
G31.2 Degeneration of nervous system due to alcohol
0.636 0.364 0.000
O62.4 Hypertonic, incoordinate and prolonged uterine contractions
0.635 0.365 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.635 0.365 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.635 0.365 0.000
G92 Toxic encephalopathy
0.635 0.365 0.000
L52 Erythema nodosum
0.634 0.366 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.634 0.366 0.000
G90.2 Horner's syndrome
0.633 0.367 0.000
H44.2 Degenerative myopia
0.633 0.367 0.000
Chapter XXII Codes for special purposes
0.633 0.367 0.000
L43.9 Lichen planus, unspecified
0.633 0.367 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.632 0.368 0.000
Y35-Y36 Legal intervention and operations of war
0.629 0.371 0.000
Y10-Y34 Event of undetermined intent
0.629 0.371 0.000
X85-X99 Assault
0.629 0.371 0.000
X50-X57 Overexertion, travel and privation
0.629 0.371 0.000
X30-X39 Exposure to forces of nature
0.629 0.371 0.000
X10-X19 Contact with heat and hot substances
0.629 0.371 0.000
X00-X09 Exposure to smoke, fire and flames
0.629 0.371 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.629 0.371 0.000
W75-W84 Other accidental threats to breathing
0.629 0.371 0.000
W65-W74 Accidental drowning and submersion
0.629 0.371 0.000
V98-V99 Other and unspecified transport accidents
0.629 0.371 0.000
V95-V97 Air and space transport accidents
0.629 0.371 0.000
V90-V94 Water transport accidents
0.629 0.371 0.000
V70-V79 Bus occupant injured in transport accident
0.629 0.371 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.629 0.371 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.629 0.371 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.629 0.371 0.000
V01-V09 Pedestrian injured in transport accident
0.629 0.371 0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified
0.629 0.371 0.000
G95.0 Syringomyelia and syringobulbia
0.629 0.371 0.000
H33.1 Retinoschisis and retinal cysts
0.629 0.371 0.000
M88 Paget's disease of bone [osteitis deformans]
0.628 0.372 0.000
L75 Apocrine sweat disorders
0.628 0.372 0.000
L74 Eccrine sweat disorders
0.628 0.372 0.000
L70 Acne
0.628 0.372 0.000
L68 Hypertrichosis
0.628 0.372 0.000
L67 Hair colour and hair shaft abnormalities
0.628 0.372 0.000
L66 Cicatricial alopecia [scarring hair loss]
0.628 0.372 0.000
L65 Other nonscarring hair loss
0.628 0.372 0.000
L64 Androgenic alopecia
0.628 0.372 0.000
L63 Alopecia areata
0.628 0.372 0.000
L62 Nail disorders in diseases classified elsewhere
0.628 0.372 0.000
L82 Seborrhoeic keratosis
0.628 0.372 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.628 0.372 0.000
M81 Osteoporosis without pathological fracture
0.627 0.373 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.627 0.373 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.627 0.373 0.000
D69.9 Haemorrhagic condition, unspecified
0.626 0.374 0.000
D67 Hereditary factor IX deficiency
0.624 0.376 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.624 0.376 0.000
V80-V89 Other land transport accidents
0.623 0.376 0.000
R49 Voice disturbances
0.623 0.377 0.000
X20-X29 Contact with venomous animals and plants
0.623 0.377 0.000
M25.7 Osteophyte
0.622 0.378 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.622 0.378 0.000
D50-D53 Nutritional anaemias
0.622 0.378 0.000
M80 Osteoporosis with pathological fracture
0.620 0.379 0.000
H33.4 Traction detachment of retina
0.620 0.380 0.000
B15-B19 Viral hepatitis
0.620 0.380 0.000
N20-N23 Urolithiasis
0.620 0.380 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.620 0.380 0.000
D68 Other coagulation defects
0.618 0.381 0.000
D61.9 Aplastic anaemia, unspecified
0.618 0.382 0.000
X60-X84 Intentional self-harm
0.618 0.382 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.617 0.383 0.000
H33.0 Retinal detachment with retinal break
0.617 0.383 0.000
Q64 Other congenital malformations of urinary system
0.616 0.384 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.616 0.384 0.000
O72 Postpartum haemorrhage
0.616 0.384 0.000
N13.9 Obstructive and reflux uropathy, unspecified
0.615 0.384 0.000
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.615 0.385 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.613 0.387 0.000
O74 Complications of anaesthesia during labour and delivery
0.613 0.387 0.000
O71 Other obstetric trauma
0.613 0.387 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.613 0.387 0.000
O60 Preterm delivery
0.613 0.387 0.000
G95.2 Cord compression, unspecified
0.613 0.387 0.000
S90-S99 Injuries to the ankle and foot
0.612 0.388 0.000
G90.3 Multisystem degeneration
0.611 0.389 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.611 0.389 0.000
L28 Lichen simplex chronicus and prurigo
0.609 0.391 0.000
G96 Other disorders of central nervous system
0.609 0.391 0.000
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified
0.609 0.391 0.000
O62.0 Primary inadequate contractions
0.609 0.391 0.000
H54.9 Unspecified visual impairment (binocular)
0.608 0.392 0.000
M94 Other disorders of cartilage
0.607 0.393 0.000
M93 Other osteochondropathies
0.606 0.394 0.000
M24.1 Other articular cartilage disorders
0.605 0.395 0.000
R30-R39 Symptoms and signs involving the urinary system
0.604 0.396 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.603 0.397 0.000
O81 Single delivery by forceps and vacuum extractor
0.603 0.397 0.000
N99-N99 Other disorders of the genitourinary system
0.603 0.397 0.000
M87.9 Osteonecrosis, unspecified
0.603 0.397 0.000
M00 Pyogenic arthritis
0.602 0.397 0.000
N30-N39 Other diseases of urinary system
0.602 0.398 0.000
G70-G73 Diseases of myoneural junction and muscle
0.602 0.398 0.000
Y42.7 Androgens and anabolic congeners
0.602 0.398 0.000
R43.8 Other and unspecified disturbances of smell and taste
0.601 0.399 0.000
R45.8 Other symptoms and signs involving emotional state
0.601 0.399 0.000
H35.9 Retinal disorder, unspecified
0.601 0.399 0.000
Y59 Other and unspecified vaccines and biological substances
0.600 0.399 0.000
Y58 Bacterial vaccines
0.600 0.399 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.600 0.399 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.600 0.399 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.600 0.399 0.000
Y48 Anaesthetics and therapeutic gases
0.600 0.399 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.600 0.399 0.000
Q61.2 Polycystic kidney, adult type
0.600 0.400 0.000
G90.9 Disorder of autonomic nervous system, unspecified
0.600 0.400 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.599 0.401 0.000
H33.5 Other retinal detachments
0.599 0.401 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.599 0.401 0.000
L81.4 Other melanin hyperpigmentation
0.598 0.401 0.000
R25.8 Other and unspecified abnormal involuntary movements
0.598 0.402 0.000
S60-S69 Injuries to the wrist and hand
0.598 0.402 0.000
H53.9 Visual disturbance, unspecified
0.598 0.402 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.597 0.402 0.000
D80-D89 Certain disorders involving the immune mechanism
0.596 0.403 0.000
M51 Other intervertebral disk disorders
0.597 0.403 0.000
M21 Other acquired deformities of limbs
0.596 0.404 0.000
B35-B49 Mycoses
0.595 0.405 0.000
H25.2 Senile cataract, morgagnian type
0.595 0.405 0.000
G31.8 Other specified degenerative diseases of nervous system
0.595 0.405 0.000
V10-V19 Pedal cyclist injured in transport accident
0.594 0.405 0.000
H31.0 Chorioretinal scars
0.594 0.406 0.000
M41 Scoliosis
0.594 0.406 0.000
M53 Other dorsopathies, not elsewhere classified
0.594 0.406 0.000
H31.8 Other specified disorders of choroid
0.593 0.407 0.000
Q43 Other congenital malformations of intestine
0.593 0.407 0.000
M82.1 Osteoporosis in endocrine disorders
0.592 0.408 0.000
M86.9 Osteomyelitis, unspecified
0.592 0.408 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.592 0.408 0.000
R46.8 Other symptoms and signs involving appearance and behaviour
0.591 0.409 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.591 0.409 0.000
O84 Multiple delivery
0.591 0.409 0.000
O83 Other assisted single delivery
0.591 0.409 0.000
B65-B83 Helminthiases
0.590 0.410 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.590 0.410 0.000
Q23 Congenital malformations of aortic and mitral valves
0.589 0.411 0.000
D57 Sickle-cell disorders
0.588 0.412 0.000
D56 Thalassaemia
0.588 0.412 0.000
D55 Anaemia due to enzyme disorders
0.588 0.412 0.000
O86 Other puerperal infections
0.587 0.413 0.000
L05.0 Pilonidal cyst with abscess
0.587 0.413 0.000
M72.04 Palmar fascial fibromatosis [Dupuytren]-Hand
0.586 0.414 0.000
O80.8 Other single spontaneous delivery
0.586 0.414 0.000
N18 Chronic renal failure
0.586 0.414 0.000
L53.9 Erythematous condition, unspecified
0.586 0.414 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.585 0.415 0.000
R61 Hyperhidrosis
0.585 0.415 0.000
H26.8 Other specified cataract
0.584 0.416 0.000
N10 Acute tubulo-interstitial nephritis
0.584 0.416 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.584 0.416 0.000
H47.0 Disorders of optic nerve, not elsewhere classified
0.584 0.416 0.000
R26.1 Paralytic gait
0.583 0.417 0.000
R26.0 Ataxic gait
0.583 0.417 0.000
O82 Single delivery by Caesarean section
0.582 0.418 0.000
M30 Polyarteritis nodosa and related conditions
0.582 0.418 0.000
L54 Erythema in diseases classified elsewhere
0.582 0.418 0.000
L51 Erythema multiforme
0.582 0.418 0.000
D72 Other disorders of white blood cells
0.582 0.418 0.000
G95.1 Vascular myelopathies
0.581 0.418 0.000
M87.2 Osteonecrosis due to previous trauma
0.581 0.419 0.000
Y52.1 Calcium-channel blockers
0.581 0.419 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.581 0.419 0.000
M15-M19 Arthrosis
0.581 0.419 0.000
Q51 Congenital malformations of uterus and cervix
0.580 0.420 0.000
G30.9 Alzheimer's disease, unspecified
0.580 0.420 0.000
M25.76 Osteophyte (Lower leg)
0.579 0.421 0.000
G62 Other polyneuropathies
0.578 0.422 0.000
H35.2 Other proliferative retinopathy
0.577 0.423 0.000
H35.1 Retinopathy of prematurity
0.577 0.423 0.000
Q27 Other congenital malformations of peripheral vascular system
0.576 0.424 0.000
N25-N29 Other disorders of kidney and ureter
0.576 0.424 0.000
D73.9 Disease of spleen, unspecified
0.576 0.424 0.000
D73.8 Other diseases of spleen
0.576 0.424 0.000
D73.4 Cyst of spleen
0.576 0.424 0.000
D73.3 Abscess of spleen
0.576 0.424 0.000
D73.2 Chronic congestive splenomegaly
0.576 0.424 0.000
D73.1 Hypersplenism
0.576 0.424 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.576 0.424 0.000
M25.56 Pain in joint (Lower leg)
0.576 0.424 0.000
H49.1 Fourth [trochlear] nerve palsy
0.576 0.424 0.000
O90 Complications of the puerperium, not elsewhere classified
0.576 0.424 0.000
M84.9 Disorder of continuity of bone, unspecified
0.575 0.425 0.000
M84.8 Other disorders of continuity of bone
0.575 0.425 0.000
M84.4 Pathological fracture, not elsewhere classified
0.575 0.425 0.000
M84.3 Stress fracture, not elsewhere classified
0.575 0.425 0.000
M84.2 Delayed union of fracture
0.575 0.425 0.000
L60.5 Yellow nail syndrome
0.575 0.425 0.000
L60.4 Beau's lines
0.575 0.425 0.000
L60.3 Nail dystrophy
0.575 0.425 0.000
L60.2 Onychogryphosis
0.575 0.425 0.000
L60.1 Onycholysis
0.575 0.425 0.000
H33.3 Retinal breaks without detachment
0.574 0.426 0.000
L60.0 Ingrowing nail
0.574 0.426 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.574 0.426 0.000
B50-B64 Protozoal diseases
0.574 0.426 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.574 0.426 0.000
A75-A79 Rickettsioses
0.574 0.426 0.000
A70-A74 Other diseases caused by chlamydiae
0.574 0.426 0.000
A65-A69 Other spirochaetal diseases
0.574 0.426 0.000
A20-A28 Certain zoonotic bacterial diseases
0.574 0.426 0.000
A15-A19 Tuberculosis
0.574 0.426 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.574 0.426 0.000
G31.0 Circumscribed brain atrophy
0.574 0.426 0.000
M22 Disorders of patella
0.574 0.426 0.000
D69.6 Thrombocytopenia, unspecified
0.572 0.428 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.571 0.429 0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.571 0.429 0.000
L05.9 Pilonidal cyst without abscess
0.570 0.430 0.000
M54 Dorsalgia
0.570 0.430 0.000
H27.8 Other specified disorders of lens
0.570 0.430 0.000
H54.4 Blindness, one eye
0.569 0.431 0.000
O62.9 Abnormality of forces of labour, unspecified
0.568 0.432 0.000
O62.8 Other abnormalities of forces of labour
0.568 0.432 0.000
O62.1 Secondary uterine inertia
0.568 0.432 0.000
O69.2 Labour and delivery complicated by other cord entanglement
0.568 0.432 0.000
M76 Enthesopathies of lower limb, excluding foot
0.568 0.432 0.000
M46 Other inflammatory spondylopathies
0.567 0.433 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.566 0.434 0.000
M61 Calcification and ossification of muscle
0.566 0.434 0.000
M60 Myositis
0.566 0.434 0.000
M24.2 Disorder of ligament
0.566 0.434 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.566 0.434 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.566 0.434 0.000
Q66 Congenital deformities of feet
0.565 0.435 0.000
O69.1 Labour and delivery complicated by cord around neck, with compression
0.565 0.435 0.000
H54.7 Unspecified visual loss
0.565 0.435 0.000
Q89 Other congenital malformations, not elsewhere classified
0.564 0.435 0.000
H35.6 Retinal haemorrhage
0.564 0.436 0.000
M99 Biomechanical lesions, not elsewhere classified
0.563 0.437 0.000
M92 Other juvenile osteochondrosis
0.563 0.437 0.000
M91 Juvenile osteochondrosis of hip and pelvis
0.563 0.437 0.000
L44 Other papulosquamous disorders
0.562 0.437 0.000
L41 Parapsoriasis
0.562 0.437 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.562 0.437 0.000
L42 Pityriasis rosea
0.562 0.437 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.562 0.438 0.000
M25.4 Effusion of joint
0.561 0.439 0.000
R54 Senility
0.561 0.439 0.000
R27 Other lack of coordination
0.561 0.439 0.000
M24.5 Contracture of joint
0.560 0.439 0.000
H57 Other disorders of eye and adnexa
0.560 0.439 0.000
L50 Urticaria
0.560 0.440 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.560 0.440 0.000
G11 Hereditary ataxia
0.560 0.440 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.559 0.440 0.000
M24.0 Loose body in joint
0.559 0.441 0.000
R51 Headache
0.559 0.441 0.000
G43 Migraine
0.559 0.441 0.000
M49 Spondylopathies in diseases classified elsewhere
0.558 0.442 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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