TreeWAS – Variant ID: rs8001611

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M81.99 Osteoporosis, unspecified (Site unspecified)	0.000	0.709	0.291
K75.0 Abscess of liver	0.000	0.788	0.212
K75 Other inflammatory liver diseases	0.000	0.790	0.210
K75.8 Other specified inflammatory liver diseases	0.000	0.794	0.206
K75.3 Granulomatous hepatitis, not elsewhere classified	0.000	0.821	0.179
M81.9 Osteoporosis, unspecified	0.000	0.834	0.166
K75.4 Autoimmune hepatitis	0.000	0.840	0.160
K75.9 Inflammatory liver disease, unspecified	0.000	0.841	0.159
M81.98 Osteoporosis, unspecified (Other)	0.000	0.847	0.153
K75.2 Nonspecific reactive hepatitis	0.000	0.850	0.150
K75.1 Phlebitis of portal vein	0.000	0.850	0.150
M81.93 Osteoporosis, unspecified (Forearm)	0.000	0.869	0.131
M81.96 Osteoporosis, unspecified (Lower leg)	0.000	0.869	0.130
M48.02 Spinal stenosis (Cervical region)	0.131	0.869	0.000
M17.9 Gonarthrosis, unspecified	0.127	0.873	0.000
M81.94 Osteoporosis, unspecified (Hand)	0.000	0.877	0.122
M81.92 Osteoporosis, unspecified (Upper arm)	0.000	0.881	0.119
K70-K77 Diseases of liver	0.000	0.884	0.116
M17 Gonarthrosis [arthrosis of knee]	0.114	0.886	0.000
M17.1 Other primary gonarthrosis	0.114	0.886	0.000
K73 Chronic hepatitis, not elsewhere classified	0.000	0.888	0.112
M81.91 Osteoporosis, unspecified (Shoulder region)	0.000	0.892	0.108
K74 Fibrosis and cirrhosis of liver	0.000	0.897	0.103
K73.9 Chronic hepatitis, unspecified	0.000	0.899	0.101
M48.0 Spinal stenosis	0.100	0.900	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.000	0.901	0.099
K74.3 Primary biliary cirrhosis	0.000	0.901	0.099
K73.2 Chronic active hepatitis, not elsewhere classified	0.000	0.904	0.096
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.000	0.905	0.095
M93.9 Osteochondropathy, unspecified	0.093	0.907	0.000
K73.8 Other chronic hepatitis, not elsewhere classified	0.000	0.909	0.091
E89.0 Postprocedural hypothyroidism	0.000	0.909	0.091
M48 Other spondylopathies	0.091	0.909	0.000
M87 Osteonecrosis	0.091	0.909	0.000
M15-M19 Arthrosis	0.090	0.910	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.090	0.910	0.000
M86-M90 Other osteopathies	0.090	0.910	0.000
M48.09 Spinal stenosis (Site unspecified)	0.090	0.910	0.000
M93 Other osteochondropathies	0.090	0.910	0.000
M87.9 Osteonecrosis, unspecified	0.089	0.911	0.000
M91-M94 Chondropathies	0.088	0.912	0.000
K71 Toxic liver disease	0.000	0.914	0.086
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)	0.086	0.914	0.000
M17.3 Other posttraumatic gonarthrosis	0.085	0.915	0.000
K77 Liver disorders in diseases classified elsewhere	0.000	0.916	0.084
K72 Hepatic failure, not elsewhere classified	0.000	0.918	0.082
M65-M68 Disorders of synovium and tendon	0.082	0.918	0.000
M67.1 Other contracture of tendon (sheath)	0.081	0.919	0.000
M17.4 Other secondary gonarthrosis, bilateral	0.081	0.919	0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified	0.000	0.919	0.080
K73.0 Chronic persistent hepatitis, not elsewhere classified	0.000	0.919	0.080
M45-M49 Spondylopathies	0.080	0.920	0.000
K74.0 Hepatic fibrosis	0.000	0.922	0.078
M23.3 Other meniscus derangements	0.077	0.923	0.000
M87.8 Other osteonecrosis	0.077	0.923	0.000
M60-M63 Disorders of muscles	0.077	0.923	0.000
M17.2 Posttraumatic gonarthrosis, bilateral	0.076	0.924	0.000
M67 Other disorders of synovium and tendon	0.076	0.924	0.000
K74.6 Other and unspecified cirrhosis of liver	0.000	0.925	0.075
M66 Spontaneous rupture of synovium and tendon	0.074	0.926	0.000
K74.4 Secondary biliary cirrhosis	0.000	0.926	0.074
K74.2 Hepatic fibrosis with hepatic sclerosis	0.000	0.926	0.074
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)	0.074	0.926	0.000
M86 Osteomyelitis	0.074	0.926	0.000
M48.05 Spinal stenosis (Thoracolumbar region)	0.073	0.927	0.000
M48.5 Collapsed vertebra, not elsewhere classified	0.073	0.927	0.000
M23.30 Other meniscus derangements (Multiple sites)	0.072	0.928	0.000
M48.03 Spinal stenosis (Cervicothoracic region)	0.072	0.928	0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)	0.072	0.928	0.000
M05-M14 Inflammatory polyarthropathies	0.072	0.928	0.000
M87.96 Osteonecrosis, unspecified (Lower leg)	0.072	0.928	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.072	0.928	0.000
M23 Internal derangement of knee	0.071	0.929	0.000
M19 Other arthrosis	0.071	0.929	0.000
K74.1 Hepatic sclerosis	0.000	0.929	0.070
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.001	0.930	0.070
M87.3 Other secondary osteonecrosis	0.070	0.930	0.000
M87.0 Idiopathic aseptic necrosis of bone	0.070	0.930	0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.070	0.930	0.000
M62 Other disorders of muscle	0.070	0.930	0.000
M90 Osteopathies in diseases classified elsewhere	0.069	0.931	0.000
M48.00 Spinal stenosis (Multiple sites in spine)	0.069	0.931	0.000
M48.8 Other specified spondylopathies	0.069	0.931	0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)	0.068	0.932	0.000
K71.1 Toxic liver disease with hepatic necrosis	0.000	0.932	0.068
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)	0.068	0.932	0.000
M40-M43 Deforming dorsopathies	0.068	0.932	0.000
M00-M03 Infectious arthropathies	0.067	0.932	0.000
K72.9 Hepatic failure, unspecified	0.000	0.933	0.067
M23.4 Loose body in knee	0.067	0.933	0.000
M87.98 Osteonecrosis, unspecified (Other)	0.067	0.933	0.000
M06 Other rheumatoid arthritis	0.067	0.933	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.065	0.935	0.000
M06.4 Inflammatory polyarthropathy	0.065	0.935	0.000
M87.85 Other osteonecrosis (Pelvic region and thigh)	0.065	0.935	0.000
M48.4 Fatigue fracture of vertebra	0.065	0.935	0.000
M48.3 Traumatic spondylopathy	0.065	0.935	0.000
M48.2 Kissing spine	0.065	0.935	0.000
M48.1 Ankylosing hyperostosis [Forestier]	0.065	0.935	0.000
M05 Seropositive rheumatoid arthritis	0.065	0.935	0.000
M19.1 Posttraumatic arthrosis of other joints	0.065	0.935	0.000
M87.97 Osteonecrosis, unspecified (Ankle and foot)	0.065	0.935	0.000
M93.8 Other specified osteochondropathies	0.064	0.936	0.000
M93.2 Osteochondritis dissecans	0.064	0.936	0.000
M93.0 Slipped upper femoral epiphysis (nontraumatic)	0.064	0.936	0.000
M87.2 Osteonecrosis due to previous trauma	0.064	0.936	0.000
M48.04 Spinal stenosis (Thoracic region)	0.064	0.936	0.000
M87.99 Osteonecrosis, unspecified (Site unspecified)	0.064	0.936	0.000
M87.94 Osteonecrosis, unspecified (Hand)	0.064	0.936	0.000
M87.93 Osteonecrosis, unspecified (Forearm)	0.064	0.936	0.000
M87.92 Osteonecrosis, unspecified (Upper arm)	0.064	0.936	0.000
M87.90 Osteonecrosis, unspecified (Multiple sites)	0.064	0.936	0.000
M23.49 Loose body in knee-Unspec lig/men	0.064	0.936	0.000
K71.6 Toxic liver disease with hepatitis, not elsewhere classified	0.000	0.937	0.063
M23.5 Chronic instability of knee	0.063	0.937	0.000
M87.91 Osteonecrosis, unspecified (Shoulder region)	0.063	0.937	0.000
M48.9 Spondylopathy, unspecified	0.063	0.937	0.000
M86.6 Other chronic osteomyelitis	0.063	0.937	0.000
M19.17 Post-traumatic arthrosis of other joints (Ankle and foot)	0.063	0.937	0.000
K71.8 Toxic liver disease with other disorders of liver	0.000	0.938	0.062
K71.7 Toxic liver disease with fibrosis and cirrhosis of liver	0.000	0.938	0.062
K71.5 Toxic liver disease with chronic active hepatitis	0.000	0.938	0.062
K71.4 Toxic liver disease with chronic lobular hepatitis	0.000	0.938	0.062
K71.3 Toxic liver disease with chronic persistent hepatitis	0.000	0.938	0.062
K71.2 Toxic liver disease with acute hepatitis	0.000	0.938	0.062
M66.4 Spontaneous rupture of other tendons	0.062	0.938	0.000
M88 Paget's disease of bone [osteitis deformans]	0.062	0.938	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.061	0.939	0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.061	0.939	0.000
M94 Other disorders of cartilage	0.061	0.939	0.000
M87.1 Osteonecrosis due to drugs	0.060	0.939	0.000
M66.5 Spontaneous rupture of unspecified tendon	0.060	0.940	0.000
M81 Osteoporosis without pathological fracture	0.003	0.940	0.057
M05.9 Seropositive rheumatoid arthritis, unspecified	0.060	0.940	0.000
K77.8 Liver disorders in other diseases classified elsewhere	0.000	0.940	0.060
K77.0 Liver disorders in infectious and parasitic diseases classified elsewhere	0.000	0.940	0.060
M23.9 Internal derangement of knee, unspecified	0.060	0.940	0.000
M66.3 Spontaneous rupture of flexor tendons	0.060	0.940	0.000
M93.1 Kienbock's disease of adults	0.059	0.941	0.000
M62.8 Other specified disorders of muscle	0.059	0.941	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.059	0.941	0.000
K71.9 Toxic liver disease, unspecified	0.000	0.941	0.059
M15 Polyarthrosis	0.059	0.941	0.000
M66.0 Rupture of popliteal cyst	0.059	0.941	0.000
M92 Other juvenile osteochondrosis	0.059	0.941	0.000
M06.3 Rheumatoid nodule	0.059	0.941	0.000
M41 Scoliosis	0.059	0.941	0.000
M87.86 Other osteonecrosis (Lower leg)	0.058	0.942	0.000
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.058	0.942	0.000
K71.0 Toxic liver disease with cholestasis	0.000	0.942	0.058
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)	0.058	0.942	0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.058	0.942	0.000
M89 Other disorders of bone	0.057	0.943	0.000
M13 Other arthritis	0.057	0.943	0.000
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.056	0.944	0.000
M19.11 Post-traumatic arthrosis of other joints (Shoulder region)	0.056	0.944	0.000
M23.1 Discoid meniscus (congenital)	0.056	0.944	0.000
M86.4 Chronic osteomyelitis with draining sinus	0.056	0.944	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.055	0.944	0.000
M23.37 Other meniscus derangements-Capsular lig	0.056	0.944	0.000
M23.41 Loose body in knee-Ant lig/hrn men	0.055	0.944	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.055	0.944	0.000
M62.2 Ischaemic infarction of muscle	0.055	0.945	0.000
M08 Juvenile arthritis	0.055	0.945	0.000
M99 Biomechanical lesions, not elsewhere classified	0.055	0.945	0.000
M87.89 Other osteonecrosis (Site unspecified)	0.055	0.945	0.000
M87.88 Other osteonecrosis (Other)	0.055	0.945	0.000
M87.87 Other osteonecrosis (Ankle and foot)	0.055	0.945	0.000
M87.84 Other osteonecrosis (Hand)	0.055	0.945	0.000
M87.83 Other osteonecrosis (Forearm)	0.055	0.945	0.000
M87.82 Other osteonecrosis (Upper arm)	0.055	0.945	0.000
M87.81 Other osteonecrosis (Shoulder region)	0.055	0.945	0.000
M87.80 Other osteonecrosis (Multiple sites)	0.055	0.945	0.000
M87.35 Other secondary osteonecrosis (Pelvic region and thigh)	0.055	0.945	0.000
M87.05 Idiopathic aseptic necrosis of bone (Pelvic region and thigh)	0.055	0.945	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.055	0.945	0.000
M61 Calcification and ossification of muscle	0.055	0.945	0.000
M86.1 Other acute osteomyelitis	0.055	0.945	0.000
M48.86 Other specified spondylopathies (Lumbar region)	0.055	0.945	0.000
M67.9 Disorder of synovium and tendon, unspecified	0.055	0.945	0.000
M67.3 Transient synovitis	0.055	0.945	0.000
M23.99 Internal derangement of knee, unspecified (Unspecified ligament or Unspecified meniscus)	0.055	0.945	0.000
M19.2 Other secondary arthrosis	0.055	0.945	0.000
M19.8 Other specified arthrosis	0.054	0.946	0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.054	0.946	0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.054	0.946	0.000
M90.8 Osteopathy in other diseases classified elsewhere	0.053	0.946	0.000
M66.1 Rupture of synovium	0.053	0.946	0.000
M67.0 Short Achilles tendon (acquired)	0.053	0.947	0.000
K72.0 Acute and subacute hepatic failure	0.000	0.947	0.053
M48.07 Spinal stenosis (Lumbosacral region)	0.053	0.947	0.000
M23.0 Cystic meniscus	0.053	0.947	0.000
M48.50 Collapsed vertebra, not elsewhere classified (Multiple sites in spine)	0.053	0.947	0.000
M86.5 Other chronic haematogenous osteomyelitis	0.053	0.947	0.000
M86.3 Chronic multifocal osteomyelitis	0.053	0.947	0.000
M86.2 Subacute osteomyelitis	0.053	0.947	0.000
M86.0 Acute haematogenous osteomyelitis	0.053	0.947	0.000
M49 Spondylopathies in diseases classified elsewhere	0.053	0.947	0.000
M02 Reactive arthropathies	0.052	0.948	0.000
M48.58 Collapsed vertebra, not elsewhere classified (Sacral and sacrococcygeal region)	0.052	0.948	0.000
M48.57 Collapsed vertebra, not elsewhere classified (Lumbosacral region)	0.052	0.948	0.000
M48.53 Collapsed vertebra, not elsewhere classified (Cervicothoracic region)	0.052	0.948	0.000
M48.52 Collapsed vertebra, not elsewhere classified (Cervical region)	0.052	0.948	0.000
M48.51 Collapsed vertebra, not elsewhere classified (Occipito-atlanto-axial region)	0.052	0.948	0.000
M19.0 Primary arthrosis of other joints	0.052	0.948	0.000
M86.66 Other chronic osteomyelitis (Lower leg)	0.052	0.948	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.052	0.948	0.000
M41.8 Other forms of scoliosis	0.052	0.948	0.000
M06.8 Other specified rheumatoid arthritis	0.052	0.948	0.000
M62.51 Muscle wasting and atrophy, not elsewhere classified (Shoulder region)	0.051	0.949	0.000
K72.1 Chronic hepatic failure	0.000	0.949	0.051
M23.42 Loose body in knee-Pst lig/hrn men	0.051	0.949	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.051	0.949	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.051	0.949	0.000
M86.8 Other osteomyelitis	0.051	0.949	0.000
M87.24 Osteonecrosis due to previous trauma (Hand)	0.051	0.949	0.000
M62.50 Muscle wasting and atrophy, not elsewhere classified (Multiple sites)	0.051	0.949	0.000
M66.57 Spontaneous rupture of unspecified tendon (Ankle and foot)	0.050	0.949	0.000
M62.86 Other specified disorders of muscle (Lower leg)	0.051	0.949	0.000
M90.1 Periostitis in other infectious diseases classified elsewhere	0.050	0.950	0.000
M87.39 Other secondary osteonecrosis (Site unspecified)	0.050	0.950	0.000
M87.38 Other secondary osteonecrosis (Other)	0.050	0.950	0.000
M87.37 Other secondary osteonecrosis (Ankle and foot)	0.050	0.950	0.000
M87.36 Other secondary osteonecrosis (Lower leg)	0.050	0.950	0.000
M87.34 Other secondary osteonecrosis (Hand)	0.050	0.950	0.000
M87.33 Other secondary osteonecrosis (Forearm)	0.050	0.950	0.000
M87.32 Other secondary osteonecrosis (Upper arm)	0.050	0.950	0.000
M87.31 Other secondary osteonecrosis (Shoulder region)	0.050	0.950	0.000
M87.30 Other secondary osteonecrosis (Multiple sites)	0.050	0.950	0.000
M87.09 Idiopathic aseptic necrosis of bone (Site unspecified)	0.050	0.950	0.000
M87.08 Idiopathic aseptic necrosis of bone (Other)	0.050	0.950	0.000
M87.07 Idiopathic aseptic necrosis of bone (Ankle and foot)	0.050	0.950	0.000
M87.06 Idiopathic aseptic necrosis of bone (Lower leg)	0.050	0.950	0.000
M87.04 Idiopathic aseptic necrosis of bone (Hand)	0.050	0.950	0.000
M87.03 Idiopathic aseptic necrosis of bone (Forearm)	0.050	0.950	0.000
M87.02 Idiopathic aseptic necrosis of bone (Upper arm)	0.050	0.950	0.000
M87.01 Idiopathic aseptic necrosis of bone (Shoulder region)	0.050	0.950	0.000
M87.00 Idiopathic aseptic necrosis of bone (Multiple sites)	0.050	0.950	0.000
M62.0 Diastasis of muscle	0.050	0.950	0.000
M95.3 Acquired deformity of neck	0.050	0.950	0.000
M62.3 Immobility syndrome (paraplegic)	0.050	0.950	0.000
M05.8 Other seropositive rheumatoid arthritis	0.050	0.950	0.000
M90.7 Fracture of bone in neoplastic disease	0.050	0.950	0.000
M90.6 Osteitis deformans in neoplastic disease	0.050	0.950	0.000
M90.5 Osteonecrosis in other diseases classified elsewhere	0.050	0.950	0.000
M90.4 Osteonecrosis due to heamoglobinopathy	0.050	0.950	0.000
M90.3 Osteonecrosis in caisson disease	0.050	0.950	0.000
M90.2 Osteopathy in other infectious diseases classified elsewhere	0.050	0.950	0.000
M90.0 Tuberculosis of bone	0.050	0.950	0.000
M62.4 Contracture of muscle	0.049	0.950	0.000
M48.55 Collapsed vertebra, not elsewhere classified (Thoracolumbar region)	0.049	0.950	0.000
M48.89 Other specified spondylopathies (Site unspecified)	0.049	0.950	0.000
M48.88 Other specified spondylopathies (Sacral and sacrococcygeal region)	0.049	0.950	0.000
M48.85 Other specified spondylopathies (Thoracolumbar region)	0.049	0.950	0.000
M48.84 Other specified spondylopathies (Thoracic region)	0.049	0.950	0.000
M48.83 Other specified spondylopathies (Cervicothoracic region)	0.049	0.950	0.000
M48.81 Other specified spondylopathies (Occipito-atlanto-axial region)	0.049	0.950	0.000
M48.80 Other specified spondylopathies (Multiple sites in spine)	0.049	0.950	0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.049	0.951	0.000
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.049	0.951	0.000
M13.8 Other specified arthritis	0.049	0.951	0.000
M17.5 Other secondary gonarthrosis	0.049	0.951	0.000
M23.44 Loose body in knee-Lat lig/ant men	0.049	0.951	0.000
M62.59 Muscle wasting and atrophy, not elsewhere classified (Site unspecified)	0.049	0.951	0.000
M42 Spinal osteochondrosis	0.049	0.951	0.000
M23.40 Loose body in knee-Mult sites	0.049	0.951	0.000
M48.59 Collapsed vertebra, not elsewhere classified (Site unspecified)	0.049	0.951	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.049	0.951	0.000
M94.8 Other specified disorders of cartilage	0.049	0.951	0.000
M13.0 Polyarthritis, unspecified	0.049	0.951	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.049	0.951	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.049	0.951	0.000
M66.36 Spontaneous rupture of flexor tendons (Lower leg)	0.049	0.951	0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.049	0.951	0.000
M67.2 Synovial hypertrophy, not elsewhere classified	0.049	0.951	0.000
M66.47 Spontaneous rupture of other tendons (Ankle and foot)	0.048	0.952	0.000
M62.87 Other specified disorders of muscle (Ankle and foot)	0.048	0.952	0.000
M48.82 Other specified spondylopathies (Cervical region)	0.048	0.952	0.000
M87.27 Osteonecrosis due to previous trauma (Ankle and foot)	0.048	0.952	0.000
M12 Other specific arthropathies	0.048	0.952	0.000
M41.5 Other secondary scoliosis	0.048	0.952	0.000
M23.47 Loose body in knee-Capsular lig	0.048	0.952	0.000
M23.45 Loose body in knee-Pst hrn lat men	0.048	0.952	0.000
M19.03 Primary arthrosis of other joints (Forearm)	0.048	0.952	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.048	0.952	0.000
M60 Myositis	0.048	0.952	0.000
M88.8 Paget's disease of other bones	0.048	0.952	0.000
M66.46 Spontaneous rupture of other tendons (Lower leg)	0.048	0.952	0.000
M06.2 Rheumatoid bursitis	0.048	0.952	0.000
M06.1 Adult-onset Still's disease	0.048	0.952	0.000
M23.8 Other internal derangements of knee	0.048	0.952	0.000
M62.83 Other specified disorders of muscle (Forearm)	0.048	0.952	0.000
M86.69 Other chronic osteomyelitis (Site unspecified)	0.048	0.952	0.000
M66.2 Spontaneous rupture of extensor tendons	0.048	0.952	0.000
M48.87 Other specified spondylopathies (Lumbosacral region)	0.048	0.952	0.000
M06.36 Rheumatoid nodule (Lower leg)	0.048	0.952	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.048	0.952	0.000
M62.84 Other specified disorders of muscle (Hand)	0.048	0.952	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.002	0.952	0.045
M66.06 Rupture of popliteal cyst-Lower leg	0.047	0.952	0.000
M86.65 Other chronic osteomyelitis (Pelvic region and thigh)	0.047	0.952	0.000
M00 Pyogenic arthritis	0.047	0.953	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.047	0.953	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.047	0.953	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.047	0.953	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.047	0.953	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.047	0.953	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.047	0.953	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.047	0.953	0.000
M23.46 Loose body in knee-O/unsp lat men	0.047	0.953	0.000
M15.4 Erosive (osteo)arthrosis	0.047	0.953	0.000
M48.19 Ankylosing hyperostosis [Forestier] (Site unspecified)	0.047	0.953	0.000
M48.18 Ankylosing hyperostosis [Forestier] (Sacral and sacrococcygeal region)	0.047	0.953	0.000
M48.17 Ankylosing hyperostosis [Forestier] (Lumbosacral region)	0.047	0.953	0.000
M48.16 Ankylosing hyperostosis [Forestier] (Lumbar region)	0.047	0.953	0.000
M48.15 Ankylosing hyperostosis [Forestier] (Thoracolumbar region)	0.047	0.953	0.000
M48.14 Ankylosing hyperostosis [Forestier] (Thoracic region)	0.047	0.953	0.000
M48.13 Ankylosing hyperostosis [Forestier] (Cervicothoracic region)	0.047	0.953	0.000
M48.12 Ankylosing hyperostosis [Forestier] (Cervical region)	0.047	0.953	0.000
M48.11 Ankylosing hyperostosis [Forestier] (Occipito-atlanto-axial region)	0.047	0.953	0.000
M48.10 Ankylosing hyperostosis [Forestier] (Multiple sites in spine)	0.047	0.953	0.000
M48.29 Kissing spine (Site unspecified)	0.047	0.953	0.000
M48.28 Kissing spine (Sacral and sacrococcygeal region)	0.047	0.953	0.000
M48.27 Kissing spine (Lumbosacral region)	0.047	0.953	0.000
M48.26 Kissing spine (Lumbar region)	0.047	0.953	0.000
M48.25 Kissing spine (Thoracolumbar region)	0.047	0.953	0.000
M48.24 Kissing spine (Thoracic region)	0.047	0.953	0.000
M48.23 Kissing spine (Cervicothoracic region)	0.047	0.953	0.000
M48.22 Kissing spine (Cervical region)	0.047	0.953	0.000
M48.21 Kissing spine (Occipito-atlanto-axial region)	0.047	0.953	0.000
M48.20 Kissing spine (Multiple sites in spine)	0.047	0.953	0.000
M48.39 Traumatic spondylopathy (Site unspecified)	0.047	0.953	0.000
M48.38 Traumatic spondylopathy (Sacral and sacrococcygeal region)	0.047	0.953	0.000
M48.37 Traumatic spondylopathy (Lumbosacral region)	0.047	0.953	0.000
M48.36 Traumatic spondylopathy (Lumbar region)	0.047	0.953	0.000
M48.35 Traumatic spondylopathy (Thoracolumbar region)	0.047	0.953	0.000
M48.34 Traumatic spondylopathy (Thoracic region)	0.047	0.953	0.000
M48.33 Traumatic spondylopathy (Cervicothoracic region)	0.047	0.953	0.000
M48.32 Traumatic spondylopathy (Cervical region)	0.047	0.953	0.000
M48.31 Traumatic spondylopathy (Occipito-atlanto-axial region)	0.047	0.953	0.000
M48.30 Traumatic spondylopathy (Multiple sites in spine)	0.047	0.953	0.000
M48.49 Fatigue fracture of vertebra (Site unspecified)	0.047	0.953	0.000
M48.48 Fatigue fracture of vertebra (Sacral and sacrococcygeal region)	0.047	0.953	0.000
M48.47 Fatigue fracture of vertebra (Lumbosacral region)	0.047	0.953	0.000
M48.46 Fatigue fracture of vertebra (Lumbar region)	0.047	0.953	0.000
M48.45 Fatigue fracture of vertebra (Thoracolumbar region)	0.047	0.953	0.000
M48.44 Fatigue fracture of vertebra (Thoracic region)	0.047	0.953	0.000
M48.43 Fatigue fracture of vertebra (Cervicothoracic region)	0.047	0.953	0.000
M48.42 Fatigue fracture of vertebra (Cervical region)	0.047	0.953	0.000
M48.41 Fatigue fracture of vertebra (Occipito-atlanto-axial region)	0.047	0.953	0.000
M48.40 Fatigue fracture of vertebra (Multiple sites in spine)	0.047	0.953	0.000
K74.5 Biliary cirrhosis, unspecified	0.000	0.953	0.047
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.047	0.953	0.000
M05.0 Felty's syndrome	0.047	0.953	0.000
M86.67 Other chronic osteomyelitis (Ankle and foot)	0.047	0.953	0.000
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.047	0.953	0.000
M19.19 Post-traumatic arthrosis of other joints (Site unspecified)	0.046	0.953	0.000
M19.18 Post-traumatic arthrosis of other joints (Other)	0.046	0.953	0.000
M19.16 Post-traumatic arthrosis of other joints-Lower leg	0.046	0.953	0.000
M19.15 Post-traumatic arthrosis of other joints (Pelvic region and thigh)	0.046	0.953	0.000
M19.10 Post-traumatic arthrosis of other joints (Multiple sites)	0.046	0.953	0.000
M66.41 Spontaneous rupture of other tendons (Shoulder region)	0.046	0.953	0.000
M93.26 Osteochondritis dissecans knee	0.046	0.954	0.000
M93.86 Other specified osteochondropathies, lower leg	0.046	0.954	0.000
M86.9 Osteomyelitis, unspecified	0.046	0.954	0.000
M62.9 Disorder of muscle, unspecified	0.046	0.954	0.000
M99.7 Connective tissue and disk stenosis of intervertebral foramina	0.046	0.954	0.000
M87.29 Osteonecrosis due to previous trauma (Site unspecified)	0.046	0.954	0.000
M87.28 Osteonecrosis due to previous trauma (Other)	0.046	0.954	0.000
M87.26 Osteonecrosis due to previous trauma (Lower leg)	0.046	0.954	0.000
M87.23 Osteonecrosis due to previous trauma (Forearm)	0.046	0.954	0.000
M87.22 Osteonecrosis due to previous trauma (Upper arm)	0.046	0.954	0.000
M87.21 Osteonecrosis due to previous trauma (Shoulder region)	0.046	0.954	0.000
M48.96 Spondylopathy, unspecified (Lumbar region)	0.046	0.954	0.000
M66.37 Spontaneous rupture of flexor tendons (Ankle and foot)	0.046	0.954	0.000
M95.0 Acquired deformity of nose	0.046	0.954	0.000
M23.57 Chronic instability of knee (Capsular ligament)	0.046	0.954	0.000
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.046	0.954	0.000
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.046	0.954	0.000
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.046	0.954	0.000
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.046	0.954	0.000
M23.50 Chronic instability of knee (Multiple sites)	0.046	0.954	0.000
M23.16 Discoid meniscus (congenital) (Other and unspecified lateral meniscus)	0.046	0.954	0.000
M48.98 Spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.045	0.954	0.000
M48.97 Spondylopathy, unspecified (Lumbosacral region)	0.045	0.954	0.000
M48.95 Spondylopathy, unspecified (Thoracolumbar region)	0.045	0.954	0.000
M48.94 Spondylopathy, unspecified (Thoracic region)	0.045	0.954	0.000
M48.93 Spondylopathy, unspecified (Cervicothoracic region)	0.045	0.954	0.000
M48.91 Spondylopathy, unspecified (Occipito-atlanto-axial region)	0.045	0.954	0.000
M48.90 Spondylopathy, unspecified (Multiple sites in spine)	0.045	0.954	0.000
M13.00 Polyarthritis, unspecified (Multiple sites)	0.045	0.955	0.000
M86.68 Other chronic osteomyelitis (Other)	0.045	0.955	0.000
M86.64 Other chronic osteomyelitis (Hand)	0.045	0.955	0.000
M86.63 Other chronic osteomyelitis (Forearm)	0.045	0.955	0.000
M86.62 Other chronic osteomyelitis (Upper arm)	0.045	0.955	0.000
M86.61 Other chronic osteomyelitis (Shoulder region)	0.045	0.955	0.000
M86.60 Other chronic osteomyelitis (Multiple sites)	0.045	0.955	0.000
M62.6 Muscle strain	0.045	0.955	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.045	0.955	0.000
M62.26 Ischaemic infarction of muscle (Lower leg)	0.045	0.955	0.000
M89.3 Hypertrophy of bone	0.045	0.955	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.045	0.955	0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)	0.045	0.955	0.000
M06.34 Rheumatoid nodule (Hand)	0.045	0.955	0.000
M05.1 Rheumatoid lung disease	0.045	0.955	0.000
M15.9 Polyarthrosis, unspecified	0.044	0.955	0.000
M81.8 Other osteoporosis	0.002	0.955	0.042
M66.49 Spontaneous rupture of other tendons (Site unspecified)	0.044	0.956	0.000
M66.48 Spontaneous rupture of other tendons (Other)	0.044	0.956	0.000
M66.45 Spontaneous rupture of other tendons (Pelvic region and thigh)	0.044	0.956	0.000
M66.44 Spontaneous rupture of other tendons (Hand)	0.044	0.956	0.000
M66.43 Spontaneous rupture of other tendons (Forearm)	0.044	0.956	0.000
M66.42 Spontaneous rupture of other tendons (Upper arm)	0.044	0.956	0.000
M66.40 Spontaneous rupture of other tendons (Multiple sites)	0.044	0.956	0.000
M88.0 Paget's disease of skull	0.044	0.956	0.000
M48.92 Spondylopathy, unspecified (Cervical region)	0.044	0.956	0.000
M48.99 Spondylopathy, unspecified (Site unspecified)	0.044	0.956	0.000
M62.57 Muscle wasting and atrophy, not elsewhere classified (Ankle and foot)	0.044	0.956	0.000
M62.53 Muscle wasting and atrophy, not elsewhere classified (Forearm)	0.044	0.956	0.000
M62.52 Muscle wasting and atrophy, not elsewhere classified (Upper arm)	0.044	0.956	0.000
M19.27 Other secondary arthrosis (Ankle and foot)	0.044	0.956	0.000
M90.78 Fracture of bone in neoplastic disease (Other)	0.044	0.956	0.000
M15.3 Secondary multiple arthrosis	0.044	0.956	0.000
M86.46 Chronic osteomyelitis with draining sinus (Lower leg)	0.044	0.956	0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.044	0.956	0.000
M94.3 Chondrolysis	0.044	0.956	0.000
M94.1 Relapsing polychondritis	0.044	0.956	0.000
M23.6 Other spontaneous disruption of ligament(s) of knee	0.044	0.956	0.000
M05.2 Rheumatoid vasculitis	0.044	0.956	0.000
M87.20 Osteonecrosis due to previous trauma (Multiple sites)	0.044	0.956	0.000
M66.31 Spontaneous rupture of flexor tendons (Shoulder region)	0.044	0.956	0.000
M87.19 Osteonecrosis due to drugs (Site unspecified)	0.043	0.956	0.000
M87.18 Osteonecrosis due to drugs (Other)	0.043	0.956	0.000
M87.17 Osteonecrosis due to drugs (Ankle and foot)	0.043	0.956	0.000
M87.16 Osteonecrosis due to drugs (Lower leg)	0.043	0.956	0.000
M87.14 Osteonecrosis due to drugs (Hand)	0.043	0.956	0.000
M87.13 Osteonecrosis due to drugs (Forearm)	0.043	0.956	0.000
M87.12 Osteonecrosis due to drugs (Upper arm)	0.043	0.956	0.000
M87.11 Osteonecrosis due to drugs (Shoulder region)	0.043	0.956	0.000
M87.10 Osteonecrosis due to drugs (Multiple sites)	0.043	0.956	0.000
M66.59 Spontaneous rupture of unspecified tendon (Site unspecified)	0.043	0.956	0.000
M66.58 Spontaneous rupture of unspecified tendon (Other)	0.043	0.956	0.000
M66.56 Spontaneous rupture of unspecified tendon (Lower leg)	0.043	0.956	0.000
M66.55 Spontaneous rupture of unspecified tendon (Pelvic region and thigh)	0.043	0.956	0.000
M66.54 Spontaneous rupture of unspecified tendon (Hand)	0.043	0.956	0.000
M66.53 Spontaneous rupture of unspecified tendon (Forearm)	0.043	0.956	0.000
M66.52 Spontaneous rupture of unspecified tendon (Upper arm)	0.043	0.956	0.000
M66.51 Spontaneous rupture of unspecified tendon (Shoulder region)	0.043	0.956	0.000
M66.50 Spontaneous rupture of unspecified tendon (Multiple sites)	0.043	0.956	0.000
M81.6 Localised osteoporosis [Lequesne]	0.002	0.956	0.041
M81.5 Idiopathic osteoporosis	0.002	0.956	0.041
M81.1 Postoophorectomy osteoporosis	0.002	0.956	0.041
M43 Other deforming dorsopathies	0.044	0.956	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.043	0.956	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.043	0.956	0.000
M62.58 Muscle wasting and atrophy, not elsewhere classified (Other)	0.043	0.956	0.000
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.043	0.957	0.000
M96.8 Other postprocedural musculoskeletal disorders	0.043	0.957	0.000
M23.97 Internal derangement of knee, unspecified (Capsular ligament)	0.043	0.957	0.000
M23.96 Internal derangement of knee, unspecified (Other and unspecified lateral meniscus)	0.043	0.957	0.000
M23.95 Internal derangement of knee, unspecified (Posterior horn of lateral meniscus)	0.043	0.957	0.000
M23.94 Internal derangement of knee, unspecified (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.043	0.957	0.000
M23.92 Internal derangement of knee, unspecified (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.043	0.957	0.000
M23.91 Internal derangement of knee, unspecified (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.043	0.957	0.000
M23.90 Internal derangement of knee, unspecified (Multiple sites)	0.043	0.957	0.000
M62.55 Muscle wasting and atrophy, not elsewhere classified (Pelvic region and thigh)	0.043	0.957	0.000
M66.39 Spontaneous rupture of flexor tendons (Site unspecified)	0.043	0.957	0.000
M66.38 Spontaneous rupture of flexor tendons (Other)	0.043	0.957	0.000
M66.35 Spontaneous rupture of flexor tendons (Pelvic region and thigh)	0.043	0.957	0.000
M66.33 Spontaneous rupture of flexor tendons (Forearm)	0.043	0.957	0.000
M66.32 Spontaneous rupture of flexor tendons (Upper arm)	0.043	0.957	0.000
M66.30 Spontaneous rupture of flexor tendons (Multiple sites)	0.043	0.957	0.000
M94.0 Chondrocostal junction syndrome [Tietze]	0.043	0.957	0.000
M02.9 Reactive arthopathy, unspecified	0.043	0.957	0.000
M08.9 Juvenile arthritis, unspecified	0.043	0.957	0.000
M08.2 Juvenile arthritis with systemic onset	0.043	0.957	0.000
M15.8 Other polyarthrosis	0.043	0.957	0.000
M62.56 Muscle wasting and atrophy, not elsewhere classified (Lower leg)	0.043	0.957	0.000
M41.86 Other forms of scoliosis (Lumbar region)	0.043	0.957	0.000
M62.54 Muscle wasting and atrophy, not elsewhere classified (Hand)	0.043	0.957	0.000
M68.8 Other disorders of synovium and tendon in diseases classified elsewhere	0.042	0.957	0.000
M68.0 Synovitis and tenosynovitis in bacterial diseases classified elsewhere	0.042	0.957	0.000
M90.84 Osteopathy in other diseases classified elsewhere (Hand)	0.042	0.958	0.000
M95.1 Cauliflower ear	0.042	0.958	0.000
M66.09 Rupture of popliteal cyst-Site unspec	0.042	0.958	0.000
M66.08 Rupture of popliteal cyst-Other	0.042	0.958	0.000
M66.07 Rupture of popliteal cyst-Ankle/foot	0.042	0.958	0.000
M66.05 Rupture of popliteal cyst-Pelvic/thigh	0.042	0.958	0.000
M66.04 Rupture of popliteal cyst-Hand	0.042	0.958	0.000
M66.03 Rupture of popliteal cyst-Forearm	0.042	0.958	0.000
M66.02 Rupture of popliteal cyst-Upper arm	0.042	0.958	0.000
M66.01 Rupture of popliteal cyst-Shldr region	0.042	0.958	0.000
M66.00 Rupture of popliteal cyst-Mult sites	0.042	0.958	0.000
M92.5 Juvenile osteochondrosis of tibia and fibula	0.042	0.958	0.000
M92.1 Juvenile osteochondrosis of radius and ulna	0.042	0.958	0.000
M92.9 Juvenile osteochondrosis, unspecified	0.042	0.958	0.000
M92.8 Other specified juvenile osteochondrosis	0.042	0.958	0.000
M92.4 Juvenile osteochondrosis of patella	0.042	0.958	0.000
M92.3 Other juvenile osteochondrosis of upper limb	0.042	0.958	0.000
M92.2 Juvenile osteochondrosis of hand	0.042	0.958	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations