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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs869708
log Bayes Factor = 14.092
Chromosome 21   position 46,434,954  (GRCh37) Explore rs869708 on Ensembl!
Variant rs869708 is part of Cluster X0084

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter V Mental and behavioural disorders
1.000 0.000 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
1.000 0.000 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.997 0.003 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.995 0.005 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.994 0.006 0.000
I05-I09 Chronic rheumatic heart diseases
0.992 0.008 0.000
I71 Aortic aneurysm and dissection
0.991 0.009 0.000
Chapter XX External causes of morbidity and mortality
0.991 0.009 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.989 0.011 0.000
I49 Other cardiac arrhythmias
0.989 0.011 0.000
I08 Multiple valve diseases
0.989 0.011 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.982 0.018 0.000
Chapter VI Diseases of the nervous system
0.978 0.022 0.000
G90-G99 Other disorders of the nervous system
0.977 0.023 0.000
M70-M79 Other soft tissue disorders
0.970 0.030 0.000
I74 Arterial embolism and thrombosis
0.968 0.032 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.968 0.032 0.000
T92 Sequelae of injuries of upper limb
0.963 0.037 0.000
F10.2 Dependence syndrome
0.960 0.040 0.000
I08.0 Disorders of both mitral and aortic valves
0.960 0.040 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.954 0.046 0.000
I35 Nonrheumatic aortic valve disorders
0.950 0.050 0.000
G93 Other disorders of brain
0.941 0.059 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.940 0.060 0.000
T92.1 Sequelae of fracture of arm
0.940 0.060 0.000
G91 Hydrocephalus
0.937 0.063 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.936 0.064 0.000
Y40 Systemic antibiotics
0.933 0.067 0.000
F30-F39 Mood [affective] disorders
0.928 0.072 0.000
I49.9 Cardiac arrhythmia, unspecified
0.928 0.072 0.000
S60-S69 Injuries to the wrist and hand
0.925 0.075 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.920 0.080 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.919 0.081 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.919 0.081 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.914 0.086 0.000
F10.1 Harmful use
0.911 0.089 0.000
F33 Recurrent depressive disorder
0.911 0.089 0.000
M65-M68 Disorders of synovium and tendon
0.903 0.097 0.000
I44 Atrioventricular and left bundle-branch block
0.902 0.098 0.000
I73 Other peripheral vascular diseases
0.901 0.099 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.900 0.100 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.898 0.102 0.000
I49.5 Sick sinus syndrome
0.898 0.102 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.898 0.102 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.896 0.104 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.896 0.104 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.895 0.105 0.000
T51 Toxic effect of alcohol
0.893 0.107 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.893 0.107 0.000
I45 Other conduction disorders
0.889 0.111 0.000
S70-S79 Injuries to the hip and thigh
0.886 0.114 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.884 0.116 0.000
G91.1 Obstructive hydrocephalus
0.883 0.117 0.000
I38 Endocarditis, valve unspecified
0.882 0.118 0.000
M86-M90 Other osteopathies
0.882 0.118 0.000
I78 Diseases of capillaries
0.881 0.119 0.000
T93 Sequelae of injuries of lower limb
0.879 0.121 0.000
F05.9 Delirium, unspecified
0.876 0.124 0.000
F10.3 Withdrawal state
0.875 0.125 0.000
T66-T78 Other and unspecified effects of external causes
0.874 0.126 0.000
Y40.9 Systemic antibiotic, unspecified
0.873 0.127 0.000
M95.0 Acquired deformity of nose
0.872 0.128 0.000
I42 Cardiomyopathy
0.871 0.129 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.871 0.129 0.000
M77 Other enthesopathies
0.867 0.133 0.000
F60-F69 Disorders of adult personality and behaviour
0.863 0.137 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.861 0.139 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.859 0.141 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.858 0.142 0.000
I45.1 Other and unspecified right bundle-branch block
0.857 0.143 0.000
I26 Pulmonary embolism
0.856 0.144 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.856 0.144 0.000
Chapter VII Diseases of the eye and adnexa
0.855 0.145 0.000
I44.1 Atrioventricular block, second degree
0.855 0.145 0.000
F11 Mental and behavioural disorders due to use of opioids
0.853 0.147 0.000
F10.0 Acute intoxication
0.853 0.147 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.847 0.153 0.000
I49.0 Ventricular fibrillation and flutter
0.846 0.154 0.000
S64 Injury of nerves at wrist and hand level
0.844 0.156 0.000
T40.2 Other opioids
0.844 0.156 0.000
I73.0 Raynaud's syndrome
0.843 0.157 0.000
M91-M94 Chondropathies
0.843 0.157 0.000
M80-M85 Disorders of bone density and structure
0.842 0.158 0.000
G93.8 Other specified disorders of brain
0.842 0.158 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.841 0.159 0.000
F33.9 Recurrent depressive disorder, unspecified
0.841 0.159 0.000
Y00-Y09 Assault
0.839 0.161 0.000
I35.1 Aortic (valve) insufficiency
0.838 0.162 0.000
M60-M63 Disorders of muscles
0.837 0.163 0.000
F40 Phobic anxiety disorders
0.836 0.164 0.000
Y52 Agents primarily affecting the cardiovascular system
0.836 0.164 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.832 0.168 0.000
G93.4 Encephalopathy, unspecified
0.831 0.169 0.000
I10-I15 Hypertensive diseases
0.830 0.170 0.000
F10.5 Psychotic disorder
0.827 0.173 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.826 0.174 0.000
V40-V49 Car occupant injured in transport accident
0.824 0.176 0.000
Chapter XXII Codes for special purposes
0.822 0.178 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.821 0.179 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.821 0.179 0.000
I47 Paroxysmal tachycardia
0.818 0.182 0.000
I78.0 Hereditary haemorrhagic telangiectasia
0.818 0.182 0.000
I31 Other diseases of pericardium
0.818 0.182 0.000
G95 Other diseases of spinal cord
0.815 0.185 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.814 0.186 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.812 0.188 0.000
G99.2 Myelopathy in diseases classified elsewhere
0.811 0.189 0.000
T51.0 Ethanol
0.808 0.192 0.000
W50-W64 Exposure to animate mechanical forces
0.804 0.196 0.000
X50-X57 Overexertion, travel and privation
0.802 0.198 0.000
I33 Acute and subacute endocarditis
0.802 0.198 0.000
M75 Shoulder lesions
0.802 0.198 0.000
I72 Other aneurysm
0.801 0.199 0.000
I74.8 Embolism and thrombosis of other arteries
0.799 0.201 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.799 0.201 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.799 0.201 0.000
I71.0 Dissection of aorta [any part]
0.799 0.201 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.799 0.201 0.000
G96 Other disorders of central nervous system
0.798 0.202 0.000
Chapter I Certain infectious and parasitic diseases
0.797 0.203 0.000
I49.4 Other and unspecified premature depolarisation
0.797 0.203 0.000
I46 Cardiac arrest
0.797 0.203 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.795 0.205 0.000
T51.9 Alcohol, unspecified
0.795 0.205 0.000
T93.1 Sequelae of fracture of femur
0.794 0.206 0.000
S64.4 Injury of digital nerve of other finger
0.794 0.206 0.000
M84 Disorders of continuity of bone
0.793 0.207 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.792 0.208 0.000
F40.2 Specific (isolated) phobias
0.792 0.208 0.000
I49.1 Atrial premature depolarisation
0.792 0.208 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.791 0.209 0.000
T68 Hypothermia
0.791 0.209 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.790 0.210 0.000
Chapter XXI Factors influencing health status and contact with health services
0.789 0.211 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.789 0.211 0.000
T45.0 Antiallergic and antiemetic drugs
0.789 0.211 0.000
S60 Superficial injury of wrist and hand
0.789 0.211 0.000
I36 Nonrheumatic tricuspid valve disorders
0.788 0.212 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.787 0.213 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.786 0.214 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.786 0.214 0.000
F33.0 Recurrent depressive disorder, current episode mild
0.785 0.215 0.000
I95 Hypotension
0.785 0.215 0.000
V20-V29 Motorcycle rider injured in transport accident
0.785 0.215 0.000
M87 Osteonecrosis
0.782 0.218 0.000
G93.9 Disorder of brain, unspecified
0.781 0.219 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.780 0.220 0.000
I08.8 Other multiple valve diseases
0.777 0.223 0.000
I99 Other and unspecified disorders of circulatory system
0.773 0.227 0.000
Z29 Need for other prophylactic measures
0.772 0.228 0.000
G93.6 Cerebral oedema
0.771 0.229 0.000
Y40.8 Other systemic antibiotics
0.771 0.229 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.771 0.229 0.000
S72 Fracture of femur
0.769 0.231 0.000
I77 Other disorders of arteries and arterioles
0.769 0.231 0.000
Z60 Problems related to social environment
0.764 0.236 0.000
T45.5 Anticoagulants
0.763 0.237 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.762 0.238 0.000
I44.3 Other and unspecified atrioventricular block
0.762 0.238 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.761 0.239 0.000
E20-E35 Disorders of other endocrine glands
0.761 0.239 0.000
Z60.2 Living alone
0.760 0.240 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.758 0.242 0.000
G91.8 Other hydrocephalus
0.758 0.242 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.758 0.242 0.000
T00-T07 Injuries involving multiple body regions
0.757 0.243 0.000
G91.0 Communicating hydrocephalus
0.757 0.243 0.000
M65 Synovitis and tenosynovitis
0.755 0.245 0.000
S10-S19 Injuries to the neck
0.754 0.246 0.000
I35.9 Aortic valve disorder, unspecified
0.754 0.246 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.753 0.247 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.752 0.248 0.000
T93.0 Sequelae of open wound of lower limb
0.752 0.248 0.000
S71 Open wound of hip and thigh
0.751 0.249 0.000
T45.2 Vitamins, not elsewhere classified
0.751 0.249 0.000
F11.2 Dependence syndrome
0.751 0.249 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.750 0.250 0.000
X60-X84 Intentional self-harm
0.750 0.250 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.750 0.250 0.000
I42.0 Dilated cardiomyopathy
0.749 0.251 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.747 0.253 0.000
M75.3 Calcific tendinitis of shoulder
0.745 0.255 0.000
T92.9 Sequelae of unspecified injury of upper limb
0.744 0.256 0.000
I37 Pulmonary valve disorders
0.744 0.256 0.000
F45 Somatoform disorders
0.743 0.257 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.742 0.257 0.000
E27 Other disorders of adrenal gland
0.742 0.258 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.742 0.258 0.000
Z29.2 Other prophylactic chemotherapy
0.741 0.259 0.000
M67 Other disorders of synovium and tendon
0.740 0.260 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.738 0.262 0.000
M77.0 Medial epicondylitis
0.737 0.263 0.000
T39.1 4-Aminophenol derivatives
0.736 0.264 0.000
M77.1 Lateral epicondylitis
0.736 0.264 0.000
H43-H45 Disorders of vitreous body and globe
0.735 0.265 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.734 0.266 0.000
G20-G26 Extrapyramidal and movement disorders
0.734 0.266 0.000
F70-F79 Mental retardation
0.733 0.266 0.000
S65 Injury of blood vessels at wrist and hand level
0.732 0.268 0.000
F02 Dementia in other diseases classified elsewhere
0.730 0.270 0.000
M70.4 Prepatellar bursitis
0.730 0.270 0.000
F60 Specific personality disorders
0.729 0.271 0.000
F43 Reaction to severe stress, and adjustment disorders
0.727 0.273 0.000
T58 Toxic effect of carbon monoxide
0.727 0.273 0.000
M66 Spontaneous rupture of synovium and tendon
0.726 0.274 0.000
I09 Other rheumatic heart diseases
0.725 0.275 0.000
Y44 Agents primarily affecting blood constituents
0.721 0.279 0.000
I35.0 Aortic (valve) stenosis
0.719 0.281 0.000
M71 Other bursopathies
0.719 0.281 0.000
T92.5 Sequelae of injury of muscle and tendon of upper limb
0.719 0.281 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.719 0.281 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.716 0.284 0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics
0.716 0.284 0.000
T82.3 Mechanical complication of other vascular grafts
0.715 0.285 0.000
B35-B49 Mycoses
0.715 0.285 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.714 0.285 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.714 0.285 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.714 0.285 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.714 0.285 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.714 0.285 0.000
F10.8 Other mental and behavioural disorders
0.713 0.287 0.000
F10.7 Residual and late-onset psychotic disorder
0.713 0.287 0.000
F10.6 Amnesic syndrome
0.713 0.287 0.000
Z22 Carrier of infectious disease
0.712 0.288 0.000
I46.9 Cardiac arrest, unspecified
0.712 0.288 0.000
I06 Rheumatic aortic valve diseases
0.711 0.288 0.000
S69 Other and unspecified injuries of wrist and hand
0.711 0.289 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.711 0.289 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.711 0.289 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.711 0.289 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.711 0.289 0.000
Y35-Y36 Legal intervention and operations of war
0.710 0.290 0.000
Y10-Y34 Event of undetermined intent
0.710 0.290 0.000
X85-X99 Assault
0.710 0.290 0.000
X30-X39 Exposure to forces of nature
0.710 0.290 0.000
X10-X19 Contact with heat and hot substances
0.710 0.290 0.000
X00-X09 Exposure to smoke, fire and flames
0.710 0.290 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.710 0.290 0.000
W75-W84 Other accidental threats to breathing
0.710 0.290 0.000
W65-W74 Accidental drowning and submersion
0.710 0.290 0.000
V98-V99 Other and unspecified transport accidents
0.710 0.290 0.000
V95-V97 Air and space transport accidents
0.710 0.290 0.000
V90-V94 Water transport accidents
0.710 0.290 0.000
V70-V79 Bus occupant injured in transport accident
0.710 0.290 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.710 0.290 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.710 0.290 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.710 0.290 0.000
V01-V09 Pedestrian injured in transport accident
0.710 0.290 0.000
M87.2 Osteonecrosis due to previous trauma
0.709 0.291 0.000
I95.9 Hypotension, unspecified
0.709 0.291 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.709 0.291 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.709 0.291 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.709 0.291 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.709 0.291 0.000
I49.2 Junctional premature depolarisation
0.709 0.291 0.000
I08.9 Multiple valve disease, unspecified
0.709 0.291 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.708 0.292 0.000
M00-M03 Infectious arthropathies
0.708 0.292 0.000
M92 Other juvenile osteochondrosis
0.708 0.292 0.000
T36 Poisoning by systemic antibiotics
0.707 0.293 0.000
G70-G73 Diseases of myoneural junction and muscle
0.707 0.293 0.000
H52 Disorders of refraction and accommodation
0.707 0.293 0.000
M89 Other disorders of bone
0.707 0.293 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.706 0.294 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.706 0.294 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.706 0.294 0.000
M76 Enthesopathies of lower limb, excluding foot
0.705 0.295 0.000
T46.1 Calcium-channel blockers
0.705 0.295 0.000
I72.3 Aneurysm of iliac artery
0.705 0.295 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.704 0.296 0.000
T95 Sequelae of burns, corrosions and frostbite
0.704 0.296 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.704 0.296 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.704 0.296 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.704 0.296 0.000
X20-X29 Contact with venomous animals and plants
0.703 0.297 0.000
T63 Toxic effect of contact with venomous animals
0.702 0.298 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.702 0.298 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.702 0.298 0.000
M70.2 Olecranon bursitis
0.702 0.298 0.000
M84.0 Malunion of fracture
0.701 0.299 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.701 0.299 0.000
G92 Toxic encephalopathy
0.701 0.299 0.000
H50 Other strabismus
0.701 0.299 0.000
H10-H13 Disorders of conjunctiva
0.701 0.299 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.700 0.300 0.000
M72 Fibroblastic disorders
0.700 0.300 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.700 0.300 0.000
G95.8 Other specified diseases of spinal cord
0.697 0.303 0.000
G93.2 Benign intracranial hypertension
0.696 0.304 0.000
Y07 Other maltreatment syndromes
0.696 0.304 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.696 0.304 0.000
I31.9 Disease of pericardium, unspecified
0.695 0.305 0.000
T40.6 Other and unspecified narcotics
0.694 0.306 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.694 0.306 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.694 0.306 0.000
Y59 Other and unspecified vaccines and biological substances
0.694 0.306 0.000
Y58 Bacterial vaccines
0.694 0.306 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.694 0.306 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.694 0.306 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.694 0.306 0.000
E00-E07 Disorders of thyroid gland
0.694 0.306 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.694 0.306 0.000
Y48 Anaesthetics and therapeutic gases
0.693 0.307 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.693 0.307 0.000
T98 Sequelae of other and unspecified effects of external causes
0.692 0.308 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.692 0.308 0.000
Z29.1 Prophylactic immunotherapy
0.692 0.308 0.000
T92.6 Sequelae of crushing injury and traumatic amputation of upper limb
0.690 0.310 0.000
T92.4 Sequelae of injury of nerve of upper limb
0.690 0.310 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.689 0.311 0.000
T82.1 Mechanical complication of cardiac electronic device
0.689 0.311 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.688 0.312 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.687 0.312 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.687 0.313 0.000
I73.8 Other specified peripheral vascular diseases
0.686 0.314 0.000
S40-S49 Injuries to the shoulder and upper arm
0.686 0.314 0.000
M60 Myositis
0.685 0.315 0.000
F69 Unspecified disorder of adult personality and behaviour
0.685 0.315 0.000
H40-H42 Glaucoma
0.685 0.315 0.000
I20-I25 Ischaemic heart diseases
0.685 0.315 0.000
S64.0 Injury of ulnar nerve at wrist and hand level
0.684 0.316 0.000
M20-M25 Other joint disorders
0.684 0.316 0.000
V48 Car occupant injured in noncollision transport accident
0.683 0.317 0.000
Q50-Q56 Congenital malformations of genital organs
0.683 0.317 0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb
0.683 0.317 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.681 0.319 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.680 0.320 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.680 0.320 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.680 0.320 0.000
T90 Sequelae of injuries of head
0.680 0.320 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.679 0.321 0.000
I49.8 Other specified cardiac arrhythmias
0.678 0.322 0.000
R04 Haemorrhage from respiratory passages
0.678 0.322 0.000
Y40.0 Penicillins
0.677 0.323 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.677 0.323 0.000
I45.2 Bifascicular block
0.676 0.324 0.000
I11 Hypertensive heart disease
0.676 0.324 0.000
I27 Other pulmonary heart diseases
0.675 0.325 0.000
I95.2 Hypotension due to drugs
0.675 0.325 0.000
Y40.3 Macrolides
0.675 0.325 0.000
V80-V89 Other land transport accidents
0.674 0.325 0.000
G93.7 Reye's syndrome
0.674 0.325 0.000
G93.5 Compression of brain
0.674 0.325 0.000
M75.2 Bicipital tendinitis
0.674 0.326 0.000
T65 Toxic effect of other and unspecified substances
0.674 0.326 0.000
T62 Toxic effect of other noxious substances eaten as food
0.674 0.326 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.674 0.326 0.000
T60 Toxic effect of pesticides
0.674 0.326 0.000
T57 Toxic effect of other inorganic substances
0.674 0.326 0.000
T56 Toxic effect of metals
0.674 0.326 0.000
T54 Toxic effect of corrosive substances
0.674 0.326 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.674 0.326 0.000
T52 Toxic effect of organic solvents
0.674 0.326 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.674 0.326 0.000
T55 Toxic effect of soaps and detergents
0.674 0.326 0.000
F32 Depressive episode
0.673 0.327 0.000
G91.3 Posttraumatic hydrocephalus, unspecified
0.672 0.328 0.000
G91.2 Normal-pressure hydrocephalus
0.672 0.328 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.671 0.329 0.000
M99 Biomechanical lesions, not elsewhere classified
0.671 0.329 0.000
I07 Rheumatic tricuspid valve diseases
0.671 0.329 0.000
R04.2 Haemoptysis
0.671 0.329 0.000
G00 Bacterial meningitis, not elsewhere classified
0.671 0.329 0.000
S68 Traumatic amputation of wrist and hand
0.670 0.330 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.670 0.330 0.000
M65.4 Radial styloid tenosynovitis [de Quervain]
0.669 0.331 0.000
G96.0 Cerebrospinal fluid leak
0.669 0.331 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.669 0.331 0.000
Y40.7 Antifungal antibiotics, systemically used
0.669 0.331 0.000
Y40.6 Rifamycins
0.669 0.331 0.000
Y40.5 Aminoglycosides
0.669 0.331 0.000
Y40.4 Tetracyclines
0.669 0.331 0.000
Y40.2 Chloramphenicol group
0.669 0.331 0.000
F48 Other neurotic disorders
0.668 0.332 0.000
F10.9 Unspecified mental and behavioural disorder
0.668 0.332 0.000
H46 Optic neuritis
0.667 0.333 0.000
I45.5 Other specified heart block
0.667 0.333 0.000
M94 Other disorders of cartilage
0.667 0.333 0.000
X51 Travel and motion
0.666 0.334 0.000
S72.3 Fracture of shaft of femur
0.666 0.334 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.666 0.334 0.000
F38 Other mood [affective] disorders
0.666 0.334 0.000
F34 Persistent mood [affective] disorders
0.666 0.334 0.000
F39 Unspecified mood [affective] disorder
0.666 0.334 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.664 0.336 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.664 0.336 0.000
M77.4 Metatarsalgia
0.663 0.337 0.000
M86 Osteomyelitis
0.662 0.338 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.662 0.338 0.000
W51 Striking against or bumped into by another person
0.662 0.338 0.000
S60.9 Superficial injury of wrist and hand, unspecified
0.662 0.338 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.661 0.338 0.000
I42.9 Cardiomyopathy, unspecified
0.660 0.340 0.000
M62 Other disorders of muscle
0.660 0.340 0.000
Y04 Assault by bodily force
0.660 0.340 0.000
I33.0 Acute and subacute infective endocarditis
0.660 0.340 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.659 0.340 0.000
F09 Unspecified organic or symptomatic mental disorder
0.659 0.340 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.659 0.340 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.659 0.341 0.000
Z20 Contact with and exposure to communicable diseases
0.659 0.341 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.659 0.341 0.000
T45.8 Other primarily systemic and haematological agents
0.659 0.341 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.659 0.341 0.000
T45.6 Fibrinolysis-affecting drugs
0.659 0.341 0.000
T45.4 Iron and its compounds
0.659 0.341 0.000
T45.3 Enzymes, not elsewhere classified
0.659 0.341 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.659 0.341 0.000
I28 Other diseases of pulmonary vessels
0.659 0.341 0.000
B15-B19 Viral hepatitis
0.658 0.342 0.000
T79-T79 Certain early complications of trauma
0.658 0.342 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.658 0.342 0.000
Y76 Obstetric and gynaecological devices associated with adverse incidents
0.658 0.342 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.656 0.343 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.656 0.344 0.000
E27.1 Primary adrenocortical insufficiency
0.656 0.344 0.000
S71.1 Open wound of thigh
0.655 0.345 0.000
S72.1 Pertrochanteric fracture
0.655 0.345 0.000
F05.0 Delirium not superimposed on dementia, so described
0.654 0.345 0.000
Q80-Q89 Other congenital malformations
0.654 0.346 0.000
E05.9 Thyrotoxicosis, unspecified
0.654 0.346 0.000
F10.4 Withdrawal state with delirium
0.654 0.346 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.653 0.347 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.653 0.347 0.000
F33.8 Other recurrent depressive disorders
0.653 0.347 0.000
F33.4 Recurrent depressive disorder, currently in remission
0.653 0.347 0.000
V43 Car occupant injured in collision with car, pick-up truck or van
0.652 0.348 0.000
I47.0 Reentry ventricular arrhythmia
0.652 0.348 0.000
G94.1 Hydrocephalus in neoplastic disease
0.651 0.349 0.000
T39.0 Salicylates
0.649 0.351 0.000
Y54.3 Benzothiadiazine derivatives
0.648 0.352 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.648 0.352 0.000
S62 Fracture at wrist and hand level
0.648 0.352 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.647 0.352 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.647 0.353 0.000
I44.5 Left posterior fascicular block
0.647 0.353 0.000
I44.4 Left anterior fascicular block
0.647 0.353 0.000
I42.8 Other cardiomyopathies
0.647 0.353 0.000
F42 Obsessive-compulsive disorder
0.646 0.353 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.646 0.354 0.000
G30-G32 Other degenerative diseases of the nervous system
0.646 0.354 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.646 0.354 0.000
F44 Dissociative [conversion] disorders
0.645 0.355 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.645 0.355 0.000
H43 Disorders of vitreous body
0.645 0.355 0.000
M95.9 Acquired deformity of musculoskeletal system, unspecified
0.644 0.356 0.000
M95.8 Other specified acquired deformities of musculoskeletal system
0.644 0.356 0.000
M95.5 Acquired deformity of pelvis
0.644 0.356 0.000
M95.4 Acquired deformity of chest and rib
0.644 0.356 0.000
M95.3 Acquired deformity of neck
0.644 0.356 0.000
M95.2 Other acquired deformity of head
0.644 0.356 0.000
M95.1 Cauliflower ear
0.644 0.356 0.000
I12 Hypertensive renal disease
0.644 0.356 0.000
M77.02 Medial epicondylitis (Upper arm)
0.644 0.356 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.643 0.356 0.000
T93.2 Sequelae of other fractures of lower limb
0.642 0.357 0.000
I34 Nonrheumatic mitral valve disorders
0.642 0.358 0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.642 0.358 0.000
T40.8 Lysergide [LSD]
0.642 0.358 0.000
T40.7 Cannabis (derivatives)
0.642 0.358 0.000
T40.5 Cocaine
0.642 0.358 0.000
T40.3 Methadone
0.642 0.358 0.000
T40.1 Heroin
0.642 0.358 0.000
T40.0 Opium
0.642 0.358 0.000
M70.5 Other bursitis of knee
0.642 0.358 0.000
M75.5 Bursitis of shoulder
0.642 0.358 0.000
F05.8 Other delirium
0.641 0.359 0.000
F05.1 Delirium superimposed on dementia
0.641 0.359 0.000
M77.12 Lateral epicondylitis (Upper arm)
0.641 0.359 0.000
T51.8 Other alcohols
0.641 0.359 0.000
T51.3 Fusel oil
0.641 0.359 0.000
T51.2 2-Propanol
0.641 0.359 0.000
T51.1 Methanol
0.641 0.359 0.000
G93.0 Cerebral cysts
0.640 0.359 0.000
M40-M43 Deforming dorsopathies
0.640 0.360 0.000
F01 Vascular dementia
0.640 0.360 0.000
I44.6 Other and unspecified fascicular block
0.640 0.360 0.000
I42.2 Other hypertrophic cardiomyopathy
0.639 0.361 0.000
B99-B99 Other infectious diseases
0.639 0.361 0.000
I24 Other acute ischaemic heart diseases
0.639 0.361 0.000
I42.6 Alcoholic cardiomyopathy
0.638 0.361 0.000
M70.46 Prepatellar bursitis-Lower Leg
0.638 0.362 0.000
I45.8 Other specified conduction disorders
0.637 0.362 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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