TreeWAS – Variant ID: rs877767

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
I30-I52 Other forms of heart disease	1.000	0.000
# Top node	1.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000
K20-K31 Diseases of oesophagus, stomach and duodenum	1.000	0.000
Chapter XI Diseases of the digestive system	0.999	0.001
Chapter X Diseases of the respiratory system	0.999	0.001
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.997	0.003
I35 Nonrheumatic aortic valve disorders	0.988	0.012
K22 Other diseases of oesophagus	0.988	0.012
Chapter XII Diseases of the skin and subcutaneous tissue	0.985	0.015
K20 Oesophagitis	0.983	0.017
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.980	0.020
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.979	0.021
I51 Complications and ill-defined descriptions of heart disease	0.971	0.029
K21 Gastro-oesophageal reflux disease	0.970	0.030
I35.0 Aortic (valve) stenosis	0.969	0.031
Chapter VII Diseases of the eye and adnexa	0.966	0.034
K21.9 Gastro-oesophageal reflux disease without oesophagitis	0.963	0.037
M50-M54 Other dorsopathies	0.957	0.043
I42 Cardiomyopathy	0.951	0.049
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.950	0.050
I46 Cardiac arrest	0.949	0.051
Chapter I Certain infectious and parasitic diseases	0.948	0.052
I50 Heart failure	0.947	0.053
K22.7 Barrett's oesophagus	0.945	0.055
L80-L99 Other disorders of the skin and subcutaneous tissue	0.944	0.056
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.936	0.064
M45-M49 Spondylopathies	0.929	0.071
Chapter VI Diseases of the nervous system	0.929	0.071
Chapter IV Endocrine, nutritional and metabolic diseases	0.928	0.072
M54 Dorsalgia	0.927	0.073
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.918	0.082
K22.1 Ulcer of oesophagus	0.914	0.086
J30-J39 Other diseases of upper respiratory tract	0.912	0.088
I80 Phlebitis and thrombophlebitis	0.910	0.090
I34 Nonrheumatic mitral valve disorders	0.909	0.091
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.907	0.093
H30-H36 Disorders of choroid and retina	0.905	0.095
I46.0 Cardiac arrest with successful resuscitation	0.903	0.097
J95-J99 Other diseases of the respiratory system	0.903	0.097
I49 Other cardiac arrhythmias	0.902	0.098
H43-H45 Disorders of vitreous body and globe	0.901	0.099
I51.8 Other ill-defined heart diseases	0.900	0.100
M47 Spondylosis	0.893	0.107
K26 Duodenal ulcer	0.889	0.111
E00-E07 Disorders of thyroid gland	0.888	0.112
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.887	0.113
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.884	0.116
T81 Complications of procedures, not elsewhere classified	0.881	0.119
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.876	0.124
J40-J47 Chronic lower respiratory diseases	0.873	0.127
B95-B98 Bacterial, viral and other infectious agents	0.873	0.127
M54.5 Low back pain	0.872	0.128
Chapter VIII Diseases of the ear and mastoid process	0.871	0.129
J80-J84 Other respiratory diseases principally affecting the interstitium	0.862	0.138
I47 Paroxysmal tachycardia	0.858	0.142
L82 Seborrhoeic keratosis	0.858	0.142
I51.9 Heart disease, unspecified	0.857	0.143
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.856	0.144
T81.4 Infection following a procedure, not elsewhere classified	0.855	0.145
L60-L75 Disorders of skin appendages	0.852	0.148
I34.0 Mitral (valve) insufficiency	0.852	0.148
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.849	0.151
K40-K46 Hernia	0.845	0.155
I50.1 Left ventricular failure	0.843	0.157
H43 Disorders of vitreous body	0.843	0.157
E03 Other hypothyroidism	0.841	0.159
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.838	0.162
I20-I25 Ischaemic heart diseases	0.835	0.165
M47.8 Other spondylosis	0.834	0.166
J20-J22 Other acute lower respiratory infections	0.833	0.167
L00-L08 Infections of the skin and subcutaneous tissue	0.830	0.170
J09-J18 Influenza and pneumonia	0.828	0.172
E20-E35 Disorders of other endocrine glands	0.824	0.176
I42.2 Other hypertrophic cardiomyopathy	0.822	0.178
I42.0 Dilated cardiomyopathy	0.817	0.183
I35.9 Aortic valve disorder, unspecified	0.816	0.184
M40-M43 Deforming dorsopathies	0.815	0.185
J98 Other respiratory disorders	0.814	0.186
A00-A09 Intestinal infectious diseases	0.814	0.186
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters	0.812	0.188
I35.2 Aortic (valve) stenosis with insufficiency	0.812	0.188
K50-K52 Noninfective enteritis and colitis	0.810	0.190
J00-J06 Acute upper respiratory infections	0.808	0.192
E03.9 Hypothyroidism, unspecified	0.808	0.192
I49.0 Ventricular fibrillation and flutter	0.807	0.193
L50-L54 Urticaria and erythema	0.802	0.198
I95-I99 Other and unspecified disorders of the circulatory system	0.801	0.199
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.800	0.200
G50-G59 Nerve, nerve root and plexus disorders	0.799	0.201
L91 Hypertrophic disorders of skin	0.799	0.201
I05-I09 Chronic rheumatic heart diseases	0.799	0.201
J90-J94 Other diseases of pleura	0.798	0.202
R91 Abnormal findings on diagnostic imaging of lung	0.794	0.206
I50.0 Congestive heart failure	0.794	0.206
D60-D64 Aplastic and other anaemias	0.792	0.208
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.791	0.209
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.790	0.210
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.790	0.210
I84 Haemorrhoids	0.784	0.216
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.783	0.216
I44 Atrioventricular and left bundle-branch block	0.782	0.218
J32 Chronic sinusitis	0.781	0.219
K40 Inguinal hernia	0.780	0.220
M50 Cervical disk disorders	0.779	0.221
H43.8 Other disorders of vitreous body	0.779	0.221
S20-S29 Injuries to the thorax	0.778	0.222
I51.7 Cardiomegaly	0.778	0.222
K26.9 Unspecified as acute or chronic, without haemorrhage or perforation	0.777	0.223
H33 Retinal detachments and breaks	0.777	0.223
I42.1 Obstructive hypertrophic cardiomyopathy	0.776	0.224
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.776	0.224
I21 Acute myocardial infarction	0.775	0.225
T36-T50 Poisoning by drugs, medicaments and biological substances	0.774	0.225
I50.9 Heart failure, unspecified	0.774	0.226
S90-S99 Injuries to the ankle and foot	0.773	0.227
S39 Other and unspecified injuries of abdomen, lower back and pelvis	0.773	0.227
M54.2 Cervicalgia	0.769	0.231
H34 Retinal vascular occlusions	0.768	0.232
H53-H54 Visual disturbances and blindness	0.768	0.232
S00-S09 Injuries to the head	0.767	0.233
G20-G26 Extrapyramidal and movement disorders	0.767	0.233
Chapter XXII Codes for special purposes	0.766	0.234
K25 Gastric ulcer	0.764	0.235
J84 Other interstitial pulmonary diseases	0.764	0.236
M70-M79 Other soft tissue disorders	0.763	0.237
L97 Ulcer of lower limb, not elsewhere classified	0.763	0.237
H10-H13 Disorders of conjunctiva	0.763	0.237
K31 Other diseases of stomach and duodenum	0.762	0.238
K22.0 Achalasia of cardia	0.761	0.239
E05 Thyrotoxicosis [hyperthyroidism]	0.760	0.240
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.759	0.241
K30 Dyspepsia	0.759	0.241
M47.9 Spondylosis, unspecified	0.759	0.241
K27 Peptic ulcer, site unspecified	0.757	0.242
K40.2 Bilateral inguinal hernia, without obstruction or gangrene	0.756	0.244
S40-S49 Injuries to the shoulder and upper arm	0.755	0.245
K22.2 Oesophageal obstruction	0.755	0.245
M54.56 Low back pain (Lumbar region)	0.754	0.246
R93 Abnormal findings on diagnostic imaging of other body structures	0.754	0.246
B35-B49 Mycoses	0.752	0.248
I21.9 Acute myocardial infarction, unspecified	0.751	0.249
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.749	0.251
I60-I69 Cerebrovascular diseases	0.748	0.252
D50-D53 Nutritional anaemias	0.746	0.254
E50-E64 Other nutritional deficiencies	0.745	0.255
K22.4 Dyskinesia of oesophagus	0.742	0.258
H90-H95 Other disorders of ear	0.742	0.258
T85 Complications of other internal prosthetic devices, implants and grafts	0.742	0.258
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters	0.740	0.260
Q60-Q64 Congenital malformations of the urinary system	0.739	0.261
T15-T19 Effects of foreign body entering through natural orifice	0.737	0.262
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.735	0.265
M47.82 Other spondylosis (Cervical region)	0.735	0.265
L81 Other disorders of pigmentation	0.734	0.266
T88 Other complications of surgical and medical care, not elsewhere classified	0.734	0.266
M54.4 Lumbago with sciatica	0.733	0.266
G90-G99 Other disorders of the nervous system	0.732	0.268
I46.9 Cardiac arrest, unspecified	0.732	0.268
S30 Superficial injury of abdomen, lower back and pelvis	0.730	0.270
J45 Asthma	0.730	0.270
H35 Other retinal disorders	0.729	0.271
J60-J70 Lung diseases due to external agents	0.728	0.272
H55-H59 Other disorders of eye and adnexa	0.727	0.272
I42.9 Cardiomyopathy, unspecified	0.727	0.273
S32 Fracture of lumbar spine and pelvis	0.726	0.274
T90 Sequelae of injuries of head	0.726	0.274
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.725	0.274
L20-L30 Dermatitis and eczema	0.725	0.275
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.723	0.277
I47.1 Supraventricular tachycardia	0.723	0.277
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.722	0.277
J43 Emphysema	0.722	0.278
M80-M85 Disorders of bone density and structure	0.721	0.279
M53 Other dorsopathies, not elsewhere classified	0.721	0.279
M54.59 Low back pain (Site unspecified)	0.721	0.279
A04 Other bacterial intestinal infections	0.720	0.280
R21 Rash and other nonspecific skin eruption	0.718	0.282
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.718	0.282
I52 Other heart disorders in diseases classified elsewhere	0.717	0.283
I48 Atrial fibrillation and flutter	0.717	0.283
I43 Cardiomyopathy in diseases classified elsewhere	0.717	0.283
I41 Myocarditis in diseases classified elsewhere	0.717	0.283
I40 Acute myocarditis	0.717	0.283
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.717	0.283
I37 Pulmonary valve disorders	0.717	0.283
I36 Nonrheumatic tricuspid valve disorders	0.717	0.283
I33 Acute and subacute endocarditis	0.717	0.283
I32 Pericarditis in diseases classified elsewhere	0.717	0.283
I30 Acute pericarditis	0.717	0.283
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
I00-I02 Acute rheumatic fever	0.717	0.283
K28 Gastrojejunal ulcer	0.717	0.283
K23 Disorders of oesophagus in diseases classified elsewhere	0.717	0.283
J38 Diseases of vocal cords and larynx, not elsewhere classified	0.717	0.283
D80-D89 Certain disorders involving the immune mechanism	0.716	0.284
T79-T79 Certain early complications of trauma	0.715	0.285
T66-T78 Other and unspecified effects of external causes	0.715	0.285
T33-T35 Frostbite	0.715	0.285
T26-T28 Burns and corrosions confined to eye and internal organs	0.715	0.285
T20-T25 Burns and corrosions of external body surface, specified by site	0.715	0.285
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.715	0.285
T00-T07 Injuries involving multiple body regions	0.715	0.285
S10-S19 Injuries to the neck	0.715	0.285
T84.0 Mechanical complication of internal joint prosthesis	0.714	0.285
J22 Unspecified acute lower respiratory infection	0.714	0.286
Q20-Q28 Congenital malformations of the circulatory system	0.714	0.286
I82 Other venous embolism and thrombosis	0.714	0.286
L60 Nail disorders	0.714	0.286
B25-B34 Other viral diseases	0.714	0.286
J34 Other disorders of nose and nasal sinuses	0.713	0.287
I49.9 Cardiac arrhythmia, unspecified	0.712	0.288
K65-K67 Diseases of peritoneum	0.712	0.288
R94 Abnormal results of function studies	0.711	0.289
L92 Granulomatous disorders of skin and subcutaneous tissue	0.709	0.291
M51 Other intervertebral disk disorders	0.708	0.292
I35.8 Other aortic valve disorders	0.708	0.292
K22.6 Gastro-oesophageal laceration-haemorrhage syndrome	0.708	0.292
K22.5 Diverticulum of oesophagus, acquired	0.708	0.292
K22.3 Perforation of oesophagus	0.708	0.292
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.707	0.293
L91.0 Keloid scar	0.706	0.294
L10-L14 Bullous disorders	0.706	0.294
J98.1 Pulmonary collapse	0.706	0.294
J99 Respiratory disorders in diseases classified elsewhere	0.705	0.295
K50 Crohn's disease [regional enteritis]	0.705	0.295
J36 Peritonsillar abscess	0.704	0.295
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.704	0.296
T87 Complications peculiar to reattachment and amputation	0.702	0.297
T86 Failure and rejection of transplanted organs and tissues	0.702	0.297
T80 Complications following infusion, transfusion and therapeutic injection	0.702	0.297
K22.9 Disease of oesophagus, unspecified	0.702	0.298
M91-M94 Chondropathies	0.702	0.298
M60-M63 Disorders of muscles	0.702	0.298
M00-M03 Infectious arthropathies	0.702	0.298
M54.3 Sciatica	0.701	0.299
I45 Other conduction disorders	0.700	0.300
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.699	0.301
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.698	0.302
H44 Disorders of globe	0.698	0.302
S60-S69 Injuries to the wrist and hand	0.697	0.303
I51.6 Cardiovascular disease, unspecified	0.696	0.304
I51.5 Myocardial degeneration	0.696	0.304
I51.4 Myocarditis, unspecified	0.696	0.304
I51.3 Intracardiac thrombosis, not elsewhere classified	0.696	0.304
I51.2 Rupture of papillary muscle, not elsewhere classified	0.696	0.304
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.696	0.304
I51.0 Cardiac septal defect, acquired	0.696	0.304
J39 Other diseases of upper respiratory tract	0.696	0.304
E21.0 Primary hyperparathyroidism	0.696	0.304
I38 Endocarditis, valve unspecified	0.695	0.305
S70-S79 Injuries to the hip and thigh	0.695	0.305
J30 Vasomotor and allergic rhinitis	0.693	0.306
H46-H48 Disorders of optic nerve and visual pathways	0.692	0.307
M45 Ankylosing spondylitis	0.690	0.310
J33 Nasal polyp	0.689	0.311
M86-M90 Other osteopathies	0.689	0.311
T83.0 Mechanical complication of urinary (indwelling) catheter	0.687	0.313
M41 Scoliosis	0.687	0.313
K26.7 Chronic without haemorrhage or perforation	0.686	0.314
L72 Follicular cysts of skin and subcutaneous tissue	0.686	0.314
I84.2 Internal haemorrhoids without complication	0.685	0.315
M47.2 Other spondylosis with radiculopathy	0.685	0.315
I49.8 Other specified cardiac arrhythmias	0.684	0.316
K70-K77 Diseases of liver	0.684	0.316
L90 Atrophic disorders of skin	0.683	0.317
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.682	0.318
I42.8 Other cardiomyopathies	0.682	0.318
I42.7 Cardiomyopathy due to drugs and other external agents	0.682	0.318
I42.6 Alcoholic cardiomyopathy	0.682	0.318
I42.5 Other restrictive cardiomyopathy	0.682	0.318
I42.4 Endocardial fibroelastosis	0.682	0.318
I42.3 Endomyocardial (eosinophilic) disease	0.682	0.318
L89 Decubitus ulcer	0.681	0.319
I88 Nonspecific lymphadenitis	0.681	0.319
I87 Other disorders of veins	0.681	0.319
I81 Portal vein thrombosis	0.681	0.319
Chapter XV Pregnancy, childbirth and the puerperium	0.680	0.320
I46.1 Sudden cardiac death, so described	0.680	0.320
B99-B99 Other infectious diseases	0.680	0.320
B90-B94 Sequelae of infectious and parasitic diseases	0.680	0.320
B85-B89 Pediculosis, acariasis and other infestations	0.680	0.320
B65-B83 Helminthiases	0.680	0.320
B50-B64 Protozoal diseases	0.680	0.320
B20-B24 Human immunodeficiency virus [HIV] disease	0.680	0.320
B15-B19 Viral hepatitis	0.680	0.320
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.680	0.320
A80-A89 Viral infections of the central nervous system	0.680	0.320
A75-A79 Rickettsioses	0.680	0.320
A70-A74 Other diseases caused by chlamydiae	0.680	0.320
A65-A69 Other spirochaetal diseases	0.680	0.320
A50-A64 Infections with a predominantly sexual mode of transmission	0.680	0.320
A20-A28 Certain zoonotic bacterial diseases	0.680	0.320
A15-A19 Tuberculosis	0.680	0.320
M46 Other inflammatory spondylopathies	0.680	0.320
I86 Varicose veins of other sites	0.679	0.321
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts	0.678	0.322
J98.0 Diseases of bronchus, not elsewhere classified	0.678	0.322
S39.9 Unspecified injury of abdomen, lower back and pelvis	0.677	0.323
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere	0.677	0.323
L95 Vasculitis limited to skin, not elsewhere classified	0.677	0.323
L94 Other localised connective tissue disorders	0.677	0.323
L93 Lupus erythematosus	0.677	0.323
L87 Transepidermal elimination disorders	0.677	0.323
L88 Pyoderma gangrenosum	0.677	0.323
L86 Keratoderma in diseases classified elsewhere	0.677	0.323
L83 Acanthosis nigricans	0.677	0.323
L80 Vitiligo	0.677	0.323
R26 Abnormalities of gait and mobility	0.676	0.324
L08 Other local infections of skin and subcutaneous tissue	0.675	0.325
I47.2 Ventricular tachycardia	0.674	0.326
B96 Other bacterial agents as the cause of diseases classified to other chapters	0.672	0.328
L53 Other erythematous conditions	0.671	0.329
L84 Corns and callosities	0.671	0.329
R95-R99 Ill-defined and unknown causes of mortality	0.671	0.329
B97 Viral agents as the cause of diseases classified to other chapters	0.671	0.329
H34.8 Other retinal vascular occlusions	0.670	0.330
E07 Other disorders of thyroid	0.669	0.330
H36 Retinal disorders in diseases classified elsewhere	0.669	0.331
L85 Other epidermal thickening	0.667	0.333
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.667	0.333
K26.4 Chronic or unspecified with haemorrhage	0.666	0.334
M49 Spondylopathies in diseases classified elsewhere	0.666	0.334
G70-G73 Diseases of myoneural junction and muscle	0.666	0.334
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.666	0.334
G00-G09 Inflammatory diseases of the central nervous system	0.666	0.334
E40-E46 Malnutrition	0.665	0.335
M54.9 Dorsalgia, unspecified	0.665	0.335
R47-R49 Symptoms and signs involving speech and voice	0.665	0.335
J32.9 Chronic sinusitis, unspecified	0.665	0.335
M54.8 Other dorsalgia	0.665	0.335
M54.6 Pain in thoracic spine	0.665	0.335
M54.1 Radiculopathy	0.665	0.335
M54.0 Panniculitis affecting regions of neck and back	0.665	0.335
H43.1 Vitreous haemorrhage	0.665	0.335
H60-H62 Diseases of external ear	0.664	0.336
R00 Abnormalities of heart beat	0.664	0.336
D51 Vitamin B12 deficiency anaemia	0.664	0.336
D63 Anaemia in chronic diseases classified elsewhere	0.663	0.337
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.663	0.337
J18 Pneumonia, organism unspecified	0.663	0.337
T82.1 Mechanical complication of cardiac electronic device	0.663	0.337
M50.0 Cervical disk disorder with myelopathy	0.663	0.337
M47.89 Other spondylosis (Site unspecified)	0.661	0.339
M72 Fibroblastic disorders	0.661	0.339
Chapter XIV Diseases of the genitourinary system	0.659	0.341
D55-D59 Haemolytic anaemias	0.658	0.342
G40-G47 Episodic and paroxysmal disorders	0.658	0.342
I95 Hypotension	0.658	0.342
J47 Bronchiectasis	0.657	0.343
H33.3 Retinal breaks without detachment	0.657	0.343
K44 Diaphragmatic hernia	0.657	0.343
E06 Thyroiditis	0.656	0.344
M54.22 Cervicalgia (Cervical region)	0.656	0.344
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.655	0.345
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified	0.654	0.346
L72.0 Epidermal cyst	0.654	0.346
H40-H42 Glaucoma	0.654	0.346
I35.1 Aortic (valve) insufficiency	0.654	0.346
J37 Chronic laryngitis and laryngotracheitis	0.654	0.346
I08 Multiple valve diseases	0.654	0.346
I20 Angina pectoris	0.653	0.347
J13 Pneumonia due to Streptococcus pneumoniae	0.653	0.347
R03 Abnormal blood-pressure reading, without diagnosis	0.653	0.347
L03 Cellulitis	0.652	0.347
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.652	0.348
I80.8 Phlebitis and thrombophlebitis of other sites	0.652	0.348
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.652	0.348
I34.9 Nonrheumatic mitral valve disorder, unspecified	0.652	0.348
I34.8 Other nonrheumatic mitral valve disorders	0.652	0.348
I34.2 Nonrheumatic mitral (valve) stenosis	0.652	0.348
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.652	0.348
T93 Sequelae of injuries of lower limb	0.651	0.349
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.651	0.349
H54 Blindness and low vision	0.651	0.349
M54.57 Low back pain (Lumbosacral region)	0.650	0.350
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis	0.650	0.350
S37 Injury of urinary and pelvic organs	0.650	0.350
S36 Injury of intra-abdominal organs	0.650	0.350
S35 Injury of blood vessels at abdomen, lower back and pelvis level	0.650	0.350
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level	0.650	0.350
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis	0.650	0.350
S31 Open wound of abdomen, lower back and pelvis	0.650	0.350
M79 Other soft tissue disorders, not elsewhere classified	0.649	0.351
H32 Chorioretinal disorders in diseases classified elsewhere	0.649	0.351
H31 Other disorders of choroid	0.649	0.351
H30 Chorioretinal inflammation	0.649	0.351
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.648	0.352
J96 Respiratory failure, not elsewhere classified	0.647	0.353
J95 Postprocedural respiratory disorders, not elsewhere classified	0.647	0.353
G59 Mononeuropathy in diseases classified elsewhere	0.647	0.353
H65-H75 Diseases of middle ear and mastoid	0.647	0.353
I49.4 Other and unspecified premature depolarisation	0.647	0.353
I49.2 Junctional premature depolarisation	0.647	0.353
I49.1 Atrial premature depolarisation	0.647	0.353
H45 Disorders of vitreous body and globe in diseases classified elsewhere	0.646	0.354
K31.7 Polyp of stomach and duodenum	0.646	0.354
K00-K14 Diseases of oral cavity, salivary glands and jaws	0.645	0.355
G55 Nerve root and plexus compressions in diseases classified elsewhere	0.645	0.355
M47.86 Other spondylosis (Lumbar region)	0.645	0.355
M47.80 Other spondylosis (Multiple sites in spine)	0.645	0.355
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.644	0.355
M65-M68 Disorders of synovium and tendon	0.644	0.355
J84.1 Other interstitial pulmonary diseases with fibrosis	0.644	0.356
I64 Stroke, not specified as haemorrhage or infarction	0.643	0.357
Q61 Cystic kidney disease	0.641	0.359
G80-G83 Cerebral palsy and other paralytic syndromes	0.641	0.359
I31 Other diseases of pericardium	0.641	0.359
M47.1 Other spondylosis with myelopathy	0.640	0.360
M47.0 Anterior spinal and vertebral artery compression syndromes	0.640	0.360
R10-R19 Symptoms and signs involving the digestive system and abdomen	0.639	0.361
Chapter XX External causes of morbidity and mortality	0.639	0.361
K26.6 Chronic or unspecified with both haemorrhage and perforation	0.637	0.363
K26.5 Chronic or unspecified with perforation	0.637	0.363
K26.3 Acute without haemorrhage or perforation	0.637	0.363
K26.2 Acute with both haemorrhage and perforation	0.637	0.363
K26.1 Acute with perforation	0.637	0.363
K26.0 Acute with haemorrhage	0.637	0.363
H80-H83 Diseases of inner ear	0.637	0.363
Chapter V Mental and behavioural disorders	0.637	0.363
M47.90 Spondylosis, unspecified (Multiple sites in spine)	0.637	0.363
G61 Inflammatory polyneuropathy	0.637	0.363
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.636	0.363
E00 Congenital iodine-deficiency syndrome	0.636	0.363
E02 Subclinical iodine-deficiency hypothyroidism	0.636	0.363
J84.9 Interstitial pulmonary disease, unspecified	0.636	0.364
R90 Abnormal findings on diagnostic imaging of central nervous system	0.636	0.364
R92 Abnormal findings on diagnostic imaging of breast	0.636	0.364
J06 Acute upper respiratory infections of multiple and unspecified sites	0.636	0.364
L05 Pilonidal cyst	0.635	0.365
I84.8 Unspecified haemorrhoids with other complications	0.634	0.366
T92 Sequelae of injuries of upper limb	0.634	0.366
A04.7 Enterocolitis due to Clostridium difficile	0.634	0.366
J01 Acute sinusitis	0.634	0.366
S02 Fracture of skull and facial bones	0.633	0.366
J45.9 Asthma, unspecified	0.633	0.367
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.633	0.367
H43.3 Other vitreous opacities	0.633	0.367
T90.2 Sequelae of fracture of skull and facial bones	0.632	0.368
I85 Oesophageal varices	0.632	0.368
T81.9 Unspecified complication of procedure	0.632	0.368
T81.7 Vascular complications following a procedure, not elsewhere classified	0.632	0.368
T81.6 Acute reaction to foreign substance accidentally left during a procedure	0.632	0.368
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure	0.632	0.368
T81.1 Shock during or resulting from a procedure, not elsewhere classified	0.632	0.368
K41 Femoral hernia	0.631	0.369
R42 Dizziness and giddiness	0.631	0.369
I49.3 Ventricular premature depolarisation	0.631	0.369
K90-K93 Other diseases of the digestive system	0.631	0.369
G62 Other polyneuropathies	0.631	0.369
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.630	0.370
G30-G32 Other degenerative diseases of the nervous system	0.629	0.371
B95.8 Unspecified staphylococcus as the cause of diseases classified to other chapters	0.629	0.371
J86 Pyothorax	0.629	0.371
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.628	0.372
Q80-Q89 Other congenital malformations	0.628	0.372
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.628	0.372
Q50-Q56 Congenital malformations of genital organs	0.628	0.372
Q38-Q45 Other congenital malformations of the digestive system	0.628	0.372
Q35-Q37 Cleft lip and cleft palate	0.628	0.372
Q30-Q34 Congenital malformations of the respiratory system	0.628	0.372
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.628	0.372
Q00-Q07 Congenital malformations of the nervous system	0.628	0.372
K22.8 Other specified diseases of oesophagus	0.627	0.373
E05.9 Thyrotoxicosis, unspecified	0.627	0.373
M48 Other spondylopathies	0.626	0.374
J41 Simple and mucopurulent chronic bronchitis	0.626	0.374
J46 Status asthmaticus	0.626	0.374
J42 Unspecified chronic bronchitis	0.626	0.374
I21.4 Acute subendocardial myocardial infarction	0.626	0.374
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.626	0.374
M54.55 Low back pain (Thoracolumbar region)	0.625	0.375
M54.54 Low back pain-Thoracic	0.625	0.375
M54.53 Low back pain-Cervicothoracic	0.625	0.375
M54.52 Low back pain-Cervical	0.625	0.375
M54.51 Low back pain-Occipit-atl-axl	0.625	0.375
M54.50 Low back pain (Multiple sites in spine)	0.625	0.375
J93 Pneumothorax	0.623	0.377
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.622	0.378
I49.5 Sick sinus syndrome	0.622	0.378
J38.7 Other diseases of larynx	0.622	0.378
J81 Pulmonary oedema	0.620	0.380
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.620	0.380
D62 Acute posthaemorrhagic anaemia	0.620	0.380
J92 Pleural plaque	0.619	0.381
I34.1 Mitral (valve) prolapse	0.619	0.381
K25.7 Chronic without haemorrhage or perforation	0.619	0.381
B95.4 Other streptococcus as the cause of diseases classified to other chapters	0.619	0.381
J82 Pulmonary eosinophilia, not elsewhere classified	0.618	0.382
J80 Adult respiratory distress syndrome	0.618	0.382
J40 Bronchitis, not specified as acute or chronic	0.617	0.382
H11 Other disorders of conjunctiva	0.617	0.383
S50-S59 Injuries to the elbow and forearm	0.616	0.383
D64 Other anaemias	0.617	0.383
D70-D77 Other diseases of blood and blood-forming organs	0.616	0.384
S05 Injury of eye and orbit	0.616	0.384
I44.2 Atrioventricular block, complete	0.615	0.385
I47.9 Paroxysmal tachycardia, unspecified	0.615	0.385
I47.0 Reentry ventricular arrhythmia	0.615	0.385
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.614	0.385

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations