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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs9257616
log Bayes Factor = 53.9187
Chromosome 6   position 29,180,721  (GRCh37) Explore rs9257616 on Ensembl!
Variant rs9257616 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.001 0.999
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.001 0.999
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E00-E07 Disorders of thyroid gland
0.000 0.002 0.998
E10.3 With ophthalmic complications
0.000 0.008 0.992
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.033 0.967
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.949 0.051 0.000
E10.1 With ketoacidosis
0.000 0.072 0.928
E10.2 With renal complications
0.000 0.083 0.917
E13 Other specified diabetes mellitus
0.000 0.084 0.916
E10.4 With neurological complications
0.000 0.139 0.861
E13.9 Without complications
0.000 0.141 0.859
E10.0 With coma
0.000 0.165 0.835
E05.8 Other thyrotoxicosis
0.000 0.165 0.835
E10.5 With peripheral circulatory complications
0.000 0.179 0.821
E16.1 Other hypoglycaemia
0.000 0.183 0.817
E14 Unspecified diabetes mellitus
0.000 0.189 0.811
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.231 0.769
E10.7 With multiple complications
0.000 0.244 0.756
E40-E46 Malnutrition
0.000 0.246 0.754
E10.6 With other specified complications
0.000 0.255 0.745
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.284 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.715
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.715
E14.3 With ophthalmic complications
0.000 0.311 0.689
E07 Other disorders of thyroid
0.000 0.317 0.683
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.319 0.681
E13.8 With unspecified complications
0.000 0.343 0.656
E13.7 With multiple complications
0.000 0.343 0.656
E13.6 With other specified complications
0.000 0.343 0.656
E13.5 With peripheral circulatory complications
0.000 0.343 0.656
E13.4 With neurological complications
0.000 0.343 0.656
E13.2 With renal complications
0.000 0.343 0.656
E13.1 With ketoacidosis
0.000 0.343 0.656
E13.0 With coma
0.000 0.343 0.656
E06 Thyroiditis
0.000 0.346 0.654
E13.3 With ophthalmic complications
0.000 0.358 0.642
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.365 0.635
E14.6 With other specified complications
0.000 0.366 0.634
E14.4 With neurological complications
0.000 0.395 0.605
E10.8 With unspecified complications
0.000 0.396 0.603
E14.1 With ketoacidosis
0.000 0.397 0.603
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.409 0.590
E14.5 With peripheral circulatory complications
0.000 0.411 0.589
E14.7 With multiple complications
0.000 0.418 0.582
E14.0 With coma
0.000 0.419 0.581
E46 Unspecified protein-energy malnutrition
0.000 0.422 0.578
E14.2 Withrenal complications
0.000 0.423 0.576
E14.8 With unspecified complications
0.000 0.424 0.576
E06.9 Thyroiditis, unspecified
0.000 0.444 0.556
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.460 0.540
E45 Retarded development following protein-energy malnutrition
0.000 0.460 0.540
E43 Unspecified severe protein-energy malnutrition
0.000 0.460 0.540
E42 Marasmic kwashiorkor
0.000 0.460 0.540
E41 Nutritional marasmus
0.000 0.460 0.540
E40 Kwashiorkor
0.000 0.460 0.540
E07.8 Other specified disorders of thyroid
0.000 0.474 0.526
C20 Malignant neoplasm of rectum
0.000 0.476 0.524
C15-C26 Malignant neoplasms of digestive organs
0.000 0.481 0.519
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.487 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.487 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.487 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.487 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.487 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.487 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.487 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.487 0.513
E03 Other hypothyroidism
0.000 0.494 0.506
E06.1 Subacute thyroiditis
0.000 0.501 0.499
E07.1 Dyshormogenetic goitre
0.000 0.510 0.490
E07.0 Hypersecretion of calcitonin
0.000 0.510 0.490
E06.4 Drug-induced thyroiditis
0.000 0.531 0.469
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.531 0.469
E06.0 Acute thyroiditis
0.000 0.531 0.469
E06.5 Other chronic thyroiditis
0.000 0.549 0.451
C25 Malignant neoplasm of pancreas
0.000 0.555 0.445
C15 Malignant neoplasm of oesophagus
0.000 0.568 0.432
E14.9 Without complications
0.000 0.585 0.415
E07.9 Disorder of thyroid, unspecified
0.000 0.594 0.406
C17 Malignant neoplasm of small intestine
0.000 0.597 0.403
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.600 0.400
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.605 0.395
E44.1 Mild protein-energy malnutrition
0.000 0.612 0.387
E44.0 Moderate protein-energy malnutrition
0.000 0.612 0.387
C25.1 Body of pancreas
0.000 0.612 0.387
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.614 0.386
K90 Intestinal malabsorption
0.000 0.616 0.384
C17.0 Duodenum
0.000 0.620 0.379
C25.2 Tail of pancreas
0.000 0.622 0.378
E11 Non-insulin-dependent diabetes mellitus
0.000 0.627 0.373
C15.4 Middle third of oesophagus
0.000 0.634 0.366
E03.5 Myxoedema coma
0.000 0.637 0.362
E03.4 Atrophy of thyroid (acquired)
0.000 0.637 0.362
E03.3 Postinfectious hypothyroidism
0.000 0.637 0.362
E50-E64 Other nutritional deficiencies
0.000 0.637 0.363
E03.8 Other specified hypothyroidism
0.000 0.640 0.360
C25.9 Pancreas, unspecified
0.000 0.643 0.357
E11.6 With other specified complications
0.000 0.645 0.355
C25.3 Pancreatic duct
0.000 0.648 0.352
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.649 0.351
E03.1 Congenital hypothyroidism without goitre
0.000 0.650 0.350
C24.0 Extrahepatic bile duct
0.000 0.654 0.346
C15.5 Lower third of oesophagus
0.000 0.661 0.339
E11.0 With coma
0.000 0.677 0.323
C15.0 Cervical part of oesophagus
0.000 0.677 0.323
C25.8 Overlapping lesion of pancreas
0.000 0.680 0.319
C25.4 Endocrine pancreas
0.000 0.680 0.319
C15.1 Thoracic part of oesophagus
0.000 0.682 0.318
E65-E68 Obesity and other hyperalimentation
0.000 0.685 0.315
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.688 0.312
C15.8 Overlapping lesion of oesophagus
0.000 0.690 0.310
C15.2 Abdominal part of oesophagus
0.000 0.690 0.310
C21 Malignant neoplasm of anus and anal canal
0.000 0.695 0.304
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.698 0.302
C17.8 Overlapping lesion of small intestine
0.000 0.711 0.289
C17.3 Meckel's diverticulum
0.000 0.711 0.289
C25.7 Other parts of pancreas
0.000 0.711 0.289
C15.9 Oesophagus, unspecified
0.000 0.712 0.288
C15.3 Upper third of oesophagus
0.000 0.718 0.282
E11.2 With renal complications
0.000 0.722 0.278
E54 Ascorbic acid deficiency
0.000 0.722 0.278
C24.8 Overlapping lesion of biliary tract
0.000 0.723 0.276
K90.3 Pancreatic steatorrhoea
0.000 0.724 0.275
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.724 0.275
K90.1 Tropical sprue
0.000 0.724 0.275
E11.7 With multiple complications
0.000 0.732 0.267
E11.1 With ketoacidosis
0.000 0.733 0.267
E51 Thiamine deficiency
0.000 0.734 0.266
C17.1 Jejunum
0.000 0.737 0.263
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.740 0.260
E63 Other nutritional deficiencies
0.000 0.740 0.260
E50 Vitamin A deficiency
0.000 0.740 0.260
E60 Dietary zinc deficiency
0.000 0.740 0.260
E59 Dietary selenium deficiency
0.000 0.740 0.260
E52 Niacin deficiency [pellagra]
0.000 0.740 0.260
I83 Varicose veins of lower extremities
0.259 0.741 0.000
E56 Other vitamin deficiencies
0.000 0.747 0.253
K90.8 Other intestinal malabsorption
0.000 0.748 0.252
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.750 0.250
C24.9 Biliary tract, unspecified
0.000 0.753 0.247
C17.2 Ileum
0.000 0.755 0.245
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.764 0.236
E58 Dietary calcium deficiency
0.000 0.764 0.236
E11.8 With unspecified complications
0.000 0.768 0.231
C22.9 Liver, unspecified
0.000 0.771 0.229
C22.1 Intrahepatic bile duct carcinoma
0.000 0.772 0.228
E67 Other hyperalimentation
0.000 0.774 0.226
E68 Sequelae of hyperalimentation
0.000 0.774 0.226
C23 Malignant neoplasm of gallbladder
0.000 0.779 0.221
K90.9 Intestinal malabsorption, unspecified
0.000 0.780 0.220
C21.2 Cloacogenic zone
0.000 0.781 0.218
C22.7 Other specified carcinomas of liver
0.000 0.783 0.217
C22.4 Other sarcomas of liver
0.000 0.783 0.217
C22.3 Angiosarcoma of liver
0.000 0.783 0.217
C22.2 Hepatoblastoma
0.000 0.783 0.217
E53 Deficiency of other B group vitamins
0.000 0.786 0.214
E55 Vitamin D deficiency
0.000 0.799 0.200
E51.2 Wernicke's encephalopathy
0.000 0.803 0.197
E51.9 Thiamine deficiency, unspecified
0.000 0.809 0.191
E51.8 Other manifestations of thiamine deficiency
0.000 0.809 0.191
E51.1 Beriberi
0.000 0.809 0.191
E50.9 Vitamin A deficiency, unspecified
0.000 0.813 0.187
E50.8 Other manifestations of vitamin A deficiency
0.000 0.813 0.187
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.813 0.187
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.813 0.187
E50.5 Vitamin A deficiency with night blindness
0.000 0.813 0.187
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.813 0.187
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.813 0.187
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.813 0.187
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.813 0.187
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.813 0.187
E63.9 Nutritional deficiency, unspecified
0.000 0.813 0.187
E63.8 Other specified nutritional deficiencies
0.000 0.813 0.187
E63.1 Imbalance of constituents of food intake
0.000 0.813 0.187
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.813 0.187
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.813 0.187
E64.8 Sequelae of other nutritional deficiencies
0.000 0.813 0.187
E64.3 Sequelae of rickets
0.000 0.813 0.187
E64.2 Sequelae of vitamin C deficiency
0.000 0.813 0.187
E64.1 Sequelae of vitamin A deficiency
0.000 0.813 0.187
E64.0 Sequelae of protein-energy malnutrition
0.000 0.813 0.187
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.182 0.818 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.818 0.182
E56.8 Deficiency of other vitamins
0.000 0.818 0.182
E56.0 Deficiency of vitamin E
0.000 0.818 0.182
C24.1 Ampulla of Vater
0.000 0.818 0.181
I83.0 Varicose veins of lower extremities with ulcer
0.182 0.818 0.000
C21.1 Anal canal
0.000 0.819 0.181
C26.8 Overlapping lesion of digestive system
0.000 0.820 0.179
C26.1 Spleen
0.000 0.820 0.179
E53.9 Vitamin B deficiency, unspecified
0.000 0.823 0.177
E56.1 Deficiency of vitamin K
0.000 0.825 0.175
E83 Disorders of mineral metabolism
0.165 0.828 0.007
C21.0 Anus, unspecified
0.000 0.830 0.170
E61 Deficiency of other nutrient elements
0.000 0.831 0.169
C17.9 Small intestine, unspecified
0.001 0.831 0.168
E67.8 Other specified hyperalimentation
0.000 0.838 0.162
E67.3 Hypervitaminosis D
0.000 0.838 0.162
E67.2 Megavitamin-B6 syndrome
0.000 0.838 0.162
E67.1 Hypercarotenaemia
0.000 0.838 0.162
E67.0 Hypervitaminosis A
0.000 0.838 0.162
E65 Localised adiposity
0.000 0.838 0.162
E53.1 Pyridoxine deficiency
0.000 0.846 0.153
E53.0 Riboflavin deficiency
0.000 0.846 0.153
E06.3 Autoimmune thyroiditis
0.001 0.851 0.148
E11.3 With ophthalmic complications
0.000 0.852 0.148
E55.0 Rickets, active
0.000 0.856 0.144
C16 Malignant neoplasm of stomach
0.000 0.856 0.143
E20-E35 Disorders of other endocrine glands
0.000 0.859 0.141
C26.9 Ill-defined sites within the digestive system
0.000 0.864 0.136
E83.3 Disorders of phosphorus metabolism
0.134 0.864 0.002
E11.5 With peripheral circulatory complications
0.000 0.867 0.133
C26.0 Intestinal tract, part unspecified
0.000 0.869 0.131
I83.1 Varicose veins of lower extremities with inflammation
0.124 0.876 0.000
E83.8 Other disorders of mineral metabolism
0.118 0.876 0.005
E83.2 Disorders of zinc metabolism
0.118 0.876 0.005
E83.0 Disorders of copper metabolism
0.118 0.876 0.005
E03.9 Hypothyroidism, unspecified
0.000 0.877 0.123
E24 Cushing's syndrome
0.000 0.878 0.122
E61.9 Deficiency of nutrient element, unspecified
0.000 0.878 0.121
E61.8 Deficiency of other specified nutrient elements
0.000 0.878 0.121
E61.7 Deficiency of multiple nutrient elements
0.000 0.878 0.121
E61.6 Vanadium deficiency
0.000 0.878 0.121
E61.5 Molybdenum deficiency
0.000 0.878 0.121
E61.4 Chromium deficiency
0.000 0.878 0.121
E61.3 Manganese deficiency
0.000 0.878 0.121
E61.0 Copper deficiency
0.000 0.878 0.121
E83.9 Disorder of mineral metabolism, unspecified
0.116 0.878 0.005
C18 Malignant neoplasm of colon
0.000 0.882 0.118
C18.1 Appendix
0.000 0.885 0.115
C25.0 Head of pancreas
0.000 0.886 0.114
E20 Hypoparathyroidism
0.000 0.890 0.109
C18.9 Colon, unspecified
0.000 0.892 0.108
C16.0 Cardia
0.000 0.893 0.107
C16.5 Lesser curvature of stomach, unspecified
0.000 0.893 0.106
E29 Testicular dysfunction
0.000 0.893 0.106
C16.2 Body of stomach
0.000 0.898 0.102
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.898 0.102
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.899 0.101
E32 Diseases of thymus
0.000 0.899 0.101
E30 Disorders of puberty, not elsewhere classified
0.000 0.899 0.101
E24.0 Pituitary-dependent Cushing's disease
0.000 0.900 0.100
E61.2 Magnesium deficiency
0.000 0.902 0.098
C16.6 Greater curvature of stomach, unspecified
0.000 0.903 0.097
E25 Adrenogenital disorders
0.000 0.903 0.097
E24.2 Drug-induced Cushing's syndrome
0.000 0.903 0.097
E24.9 Cushing's syndrome, unspecified
0.000 0.905 0.094
E31 Polyglandular dysfunction
0.000 0.905 0.094
C22.0 Liver cell carcinoma
0.000 0.906 0.093
C16.4 Pylorus
0.000 0.911 0.089
E28 Ovarian dysfunction
0.000 0.911 0.089
E21.3 Hyperparathyroidism, unspecified
0.000 0.912 0.088
C16.1 Fundus of stomach
0.000 0.912 0.088
C16.8 Overlapping lesion of stomach
0.000 0.912 0.088
E24.8 Other Cushing's syndrome
0.000 0.912 0.088
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.912 0.088
E24.3 Ectopic ACTH syndrome
0.000 0.912 0.088
E24.1 Nelson's syndrome
0.000 0.912 0.088
E20.9 Hypoparathyroidism, unspecified
0.000 0.913 0.087
E70-E90 Metabolic disorders
0.001 0.914 0.085
C18.8 Overlapping lesion of colon
0.000 0.916 0.084
E55.9 Vitamin D deficiency, unspecified
0.000 0.916 0.084
E34 Other endocrine disorders
0.000 0.918 0.082
E29.1 Testicular hypofunction
0.000 0.918 0.082
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.919 0.081
C16.9 Stomach, unspecified
0.000 0.919 0.081
E78.2 Mixed hyperlipidaemia
0.000 0.921 0.079
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.921 0.079
E20.8 Other hypoparathyroidism
0.000 0.921 0.079
E20.1 Pseudohypoparathyroidism
0.000 0.921 0.079
E20.0 Idiopathic hypoparathyroidism
0.000 0.921 0.079
E83.4 Disorders of magnesium metabolism
0.075 0.923 0.002
E29.9 Testicular dysfunction, unspecified
0.000 0.923 0.076
E29.8 Other testicular dysfunction
0.000 0.923 0.076
E29.0 Testicular hyperfunction
0.000 0.923 0.076
E61.1 Iron deficiency
0.000 0.924 0.076
E26 Hyperaldosteronism
0.000 0.925 0.075
E21.2 Other hyperparathyroidism
0.000 0.926 0.074
C18.6 Descending colon
0.000 0.926 0.074
E21.4 Other specified disorders of parathyroid gland
0.000 0.927 0.073
C16.3 Pyloric antrum
0.000 0.927 0.073
E78.1 Pure hyperglyceridaemia
0.000 0.927 0.073
E30.9 Disorder of puberty, unspecified
0.000 0.927 0.072
E30.8 Other disorders of puberty
0.000 0.927 0.072
E30.1 Precocious puberty
0.000 0.927 0.072
E30.0 Delayed puberty
0.000 0.927 0.072
E32.9 Disease of thymus, unspecified
0.000 0.927 0.072
E32.8 Other diseases of thymus
0.000 0.927 0.072
E32.1 Abscess of thymus
0.000 0.927 0.072
E32.0 Persistent hyperplasia of thymus
0.000 0.927 0.072
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.927 0.072
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.927 0.072
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.927 0.072
S02.40 Fracture of malar and maxillary bones (closed)
0.000 0.928 0.072
E11.4 With neurological complications
0.000 0.929 0.071
E25.9 Adrenogenital disorder, unspecified
0.000 0.930 0.070
E25.8 Other adrenogenital disorders
0.000 0.930 0.070
E31.9 Polyglandular dysfunction, unspecified
0.000 0.932 0.068
E31.8 Other polyglandular dysfunction
0.000 0.932 0.068
E31.1 Polyglandular hyperfunction
0.000 0.932 0.068
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.932 0.067
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.933 0.067
E85 Amyloidosis
0.001 0.933 0.066
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.934 0.066
E88 Other metabolic disorders
0.000 0.934 0.066
E23 Hypofunction and other disorders of pituitary gland
0.000 0.935 0.065
C18.7 Sigmoid colon
0.000 0.935 0.065
E28.2 Polycystic ovarian syndrome
0.000 0.935 0.064
E28.9 Ovarian dysfunction, unspecified
0.000 0.936 0.064
E28.8 Other ovarian dysfunction
0.000 0.936 0.064
E28.1 Androgen excess
0.000 0.936 0.064
E28.0 Oestrogen excess
0.000 0.936 0.064
S02.4 Fracture of malar and maxillary bones
0.000 0.937 0.063
M45.X9 Ankylosing spondylitis (Site unspecified)
0.063 0.937 0.000
E73 Lactose intolerance
0.001 0.937 0.062
E77 Disorders of glycoprotein metabolism
0.001 0.938 0.061
E76 Disorders of glycosaminoglycan metabolism
0.001 0.938 0.061
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.938 0.061
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.938 0.061
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.938 0.062
E78.6 Lipoprotein deficiency
0.000 0.938 0.062
E74 Other disorders of carbohydrate metabolism
0.001 0.938 0.061
E31.0 Autoimmune polyglandular failure
0.000 0.939 0.061
E34.3 Short stature, not elsewhere classified
0.000 0.939 0.061
E78.3 Hyperchylomicronaemia
0.000 0.940 0.060
E34.5 Androgen resistance syndrome
0.000 0.941 0.059
E34.4 Constitutional tall stature
0.000 0.941 0.059
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.941 0.059
E34.1 Other hypersecretion of intestinal hormones
0.000 0.941 0.059
E70 Disorders of aromatic amino-acid metabolism
0.001 0.941 0.058
E11.9 Without complications
0.000 0.942 0.058
S02 Fracture of skull and facial bones
0.000 0.942 0.058
C18.4 Transverse colon
0.000 0.942 0.058
E84 Cystic fibrosis
0.001 0.942 0.057
E85.4 Organ-limited amyloidosis
0.000 0.943 0.057
E79 Disorders of purine and pyrimidine metabolism
0.001 0.943 0.056
E34.8 Other specified endocrine disorders
0.000 0.943 0.057
E78.5 Hyperlipidaemia, unspecified
0.000 0.944 0.056
E34.9 Endocrine disorder, unspecified
0.000 0.944 0.056
S02.6 Fracture of mandible
0.000 0.945 0.055
E88.9 Metabolic disorder, unspecified
0.000 0.946 0.054
E72 Other disorders of amino-acid metabolism
0.001 0.946 0.053
E26.8 Other hyperaldosteronism
0.000 0.946 0.054
E26.1 Secondary hyperaldosteronism
0.000 0.946 0.054
E23.7 Disorder of pituitary gland, unspecified
0.000 0.946 0.054
E75.5 Other lipid storage disorders
0.001 0.946 0.053
E04 Other non-toxic goitre
0.000 0.947 0.052
E28.3 Primary ovarian failure
0.000 0.948 0.052
S02.60 Fracture of mandible (closed)
0.000 0.948 0.052
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.949 0.051
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.950 0.050
E75.2 Other sphingolipidosis
0.001 0.950 0.050
E26.9 Hyperaldosteronism, unspecified
0.000 0.950 0.050
E85.3 Secondary systemic amyloidosis
0.000 0.950 0.049
E78.4 Other hyperlipidaemia
0.000 0.951 0.049
S02.0 Fracture of vault of skull
0.000 0.951 0.049
S02.3 Fracture of orbital floor
0.000 0.951 0.049
E21.0 Primary hyperparathyroidism
0.000 0.951 0.049
E75.6 Lipid storage disorder, unspecified
0.001 0.951 0.048
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.951 0.048
E75.3 Sphingolipidosis, unspecified
0.001 0.951 0.048
E75.1 Other gangliosidosis
0.001 0.951 0.048
E75.0 GM2 gangliosidosis
0.001 0.951 0.048
E85.8 Other amyloidosis
0.001 0.952 0.048
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.952 0.048
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.952 0.048
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.952 0.048
C18.3 Hepatic flexure
0.000 0.952 0.048
E88.2 Lipomatosis, not elsewhere classified
0.000 0.952 0.048
S02.7 Multiple fractures involving skull and facial bones
0.000 0.952 0.048
S02.8 Fractures of other skull and facial bones
0.000 0.953 0.047
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.953 0.047
E23.1 Drug-induced hypopituitarism
0.000 0.953 0.047
E78.8 Other disorders of lipoprotein metabolism
0.000 0.953 0.047
E34.0 Carcinoid syndrome
0.000 0.953 0.046
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.954 0.046
E22 Hyperfunction of pituitary gland
0.000 0.954 0.046
E73.9 Lactose intolerance, unspecified
0.000 0.954 0.045
E73.8 Other lactose intolerance
0.001 0.955 0.045
E73.1 Secondary lactase deficiency
0.001 0.955 0.045
E73.0 Congenital lactase deficiency
0.001 0.955 0.045
E71.3 Disorders of fatty-acid metabolism
0.001 0.955 0.044
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.955 0.044
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.955 0.044
E71.0 Maple-syrup-urine disease
0.001 0.955 0.044
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.955 0.044
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.955 0.044
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.955 0.044
E76.2 Other mucopolysaccharidoses
0.001 0.955 0.044
E76.1 Mucopolysaccharidosis, type II
0.001 0.955 0.044
E76.0 Mucopolysaccharidosis, type I
0.001 0.955 0.044
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.955 0.044
E77.8 Other disorders of glycoprotein metabolism
0.001 0.955 0.044
E77.1 Defects in glycoprotein degradation
0.001 0.955 0.044
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.955 0.044
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.956 0.044
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.956 0.044
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.956 0.044
E74.2 Disorders of galactose metabolism
0.001 0.956 0.044
E74.1 Disorders of fructose metabolism
0.001 0.956 0.044
S02.00 Fracture of vault of skull (closed)
0.000 0.957 0.043
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.957 0.042
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.957 0.042
E70.2 Disorders of tyrosine metabolism
0.001 0.957 0.042
E70.1 Other hyperphenylalaninaemias
0.001 0.957 0.042
E70.0 Classical phenylketonuria
0.001 0.957 0.042
S02.41 Fracture of malar and maxillary bones (open)
0.000 0.957 0.042
S02.30 Fracture of orbital floor (closed)
0.000 0.957 0.043
E88.8 Other specified metabolic disorders
0.000 0.958 0.042
E74.0 Glycogen storage disease
0.001 0.958 0.041
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.958 0.041
E84.8 Cystic fibrosis with other manifestations
0.001 0.958 0.041
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.958 0.041
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.959 0.040
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.959 0.040
E79.1 Lesch-Nyhan syndrome
0.001 0.959 0.040
S02.5 Fracture of tooth
0.000 0.959 0.041
E88.3 Tumour lysis syndrome
0.001 0.959 0.040
S02.70 Multiple fractures involving skull and facial bones (closed)
0.000 0.960 0.040
S02.9 Fracture of skull and facial bones, part unspecified
0.000 0.960 0.040
E70.3 Albinism
0.001 0.960 0.039
S02.61 Fracture of mandible (open)
0.000 0.961 0.039
S02.80 Fractures of other skull and facial bones (closed)
0.000 0.961 0.039
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.961 0.038
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.961 0.038
E72.5 Disorders of glycine metabolism
0.001 0.961 0.038
E72.4 Disorders of ornithine metabolism
0.001 0.961 0.038
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.961 0.038
E72.2 Disorders of urea cycle metabolism
0.001 0.961 0.038
E53.8 Deficiency of other specified B group vitamins
0.000 0.962 0.038
E85.9 Amyloidosis, unspecified
0.001 0.962 0.038
E04.8 Other specified non-toxic goitre
0.000 0.962 0.038
E84.9 Cystic fibrosis, unspecified
0.001 0.962 0.037
E72.0 Disorders of amino-acid transport
0.001 0.963 0.036
Z90.5 Acquired absence of kidney
0.037 0.963 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.963 0.036
S02.2 Fracture of nasal bones
0.000 0.964 0.036
S02.01 Fracture of vault of skull (open)
0.000 0.964 0.036
S02.31 Fracture of orbital floor (open)
0.000 0.964 0.035
E23.0 Hypopituitarism
0.000 0.965 0.035
E26.0 Primary hyperaldosteronism
0.000 0.965 0.035
S02.1 Fracture of base of skull
0.000 0.965 0.035
E23.2 Diabetes insipidus
0.000 0.965 0.035
S02.71 Multiple fractures involving skull and facial bones (open)
0.000 0.965 0.034
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.965 0.034
S02.81 Fractures of other skull and facial bones (open)
0.000 0.966 0.034
E22.8 Other hyperfunction of pituitary gland
0.000 0.966 0.033
E27 Other disorders of adrenal gland
0.000 0.968 0.032
E23.6 Other disorders of pituitary gland
0.000 0.968 0.031
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.969 0.030
S02.21 Fracture of nasal bones (open)
0.000 0.970 0.030
S02.51 Fracture of tooth (open)
0.000 0.970 0.030
E66 Obesity
0.000 0.971 0.029
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.971 0.028
C18.2 Ascending colon
0.000 0.971 0.029
S02.91 Fracture of skull and facial bones, part unspecified (open)
0.000 0.971 0.029
S02.50 Fracture of tooth (closed)
0.000 0.971 0.029
E22.1 Hyperprolactinaemia
0.000 0.971 0.029
H40.2 Primary angle-closure glaucoma
0.029 0.971 0.000
E04.0 Non-toxic diffuse goitre
0.001 0.972 0.027
S02.90 Fracture of skull and facial bones, part unspecified (closed)
0.000 0.973 0.027
M45 Ankylosing spondylitis
0.026 0.974 0.000
S02.11 Fracture of base of skull (open)
0.000 0.974 0.026
E22.0 Acromegaly and pituitary gigantism
0.000 0.974 0.025
C18.5 Splenic flexure
0.001 0.975 0.024
K90-K93 Other diseases of the digestive system
0.000 0.976 0.024
E27.5 Adrenomedullary hyperfunction
0.000 0.977 0.023
E27.0 Other adrenocortical overactivity
0.000 0.977 0.023
E83.5 Disorders of calcium metabolism
0.021 0.977 0.002
E27.1 Primary adrenocortical insufficiency
0.000 0.978 0.022
E27.9 Disorder of adrenal gland, unspecified
0.000 0.979 0.021
E80.2 Other porphyria
0.001 0.979 0.021
E66.1 Drug-induced obesity
0.000 0.979 0.021
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.979 0.020

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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