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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs9263969
log Bayes Factor = 64.6554
Chromosome 6   position 31,186,534  (GRCh37) Explore rs9263969 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
R31 Unspecified haematuria
0.953 0.047 0.000
E10-E14 Diabetes mellitus
0.000 0.194 0.806
E11 Non-insulin-dependent diabetes mellitus
0.000 0.208 0.792
E10 Insulin-dependent diabetes mellitus
0.000 0.217 0.783
E11.4 With neurological complications
0.000 0.218 0.782
E13 Other specified diabetes mellitus
0.000 0.224 0.776
E10.3 With ophthalmic complications
0.000 0.244 0.756
E13.9 Without complications
0.000 0.245 0.755
E11.5 With peripheral circulatory complications
0.000 0.261 0.739
E14 Unspecified diabetes mellitus
0.000 0.267 0.733
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.300 0.700
E14.3 With ophthalmic complications
0.000 0.301 0.699
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.306 0.694
E16 Other disorders of pancreatic internal secretion
0.000 0.309 0.691
E16.2 Hypoglycaemia, unspecified
0.000 0.311 0.689
E11.8 With unspecified complications
0.000 0.336 0.664
K90 Intestinal malabsorption
0.000 0.343 0.657
E10.8 With unspecified complications
0.000 0.352 0.648
E10.2 With renal complications
0.000 0.377 0.623
E10.1 With ketoacidosis
0.000 0.393 0.607
E11.1 With ketoacidosis
0.000 0.399 0.601
E11.6 With other specified complications
0.000 0.404 0.596
E50-E64 Other nutritional deficiencies
0.000 0.405 0.595
D86.9 Sarcoidosis, unspecified
0.000 0.410 0.590
D86 Sarcoidosis
0.000 0.412 0.588
L40.9 Psoriasis, unspecified
0.000 0.421 0.579
E12 Malnutrition-related diabetes mellitus
0.000 0.422 0.578
E03 Other hypothyroidism
0.515 0.422 0.063
E11.7 With multiple complications
0.000 0.432 0.568
E14.8 With unspecified complications
0.000 0.434 0.566
E14.4 With neurological complications
0.000 0.434 0.566
E10.0 With coma
0.000 0.438 0.562
E10.7 With multiple complications
0.000 0.438 0.562
E10.4 With neurological complications
0.000 0.442 0.558
E13.8 With unspecified complications
0.000 0.444 0.556
E13.7 With multiple complications
0.000 0.444 0.556
E13.6 With other specified complications
0.000 0.444 0.556
E13.5 With peripheral circulatory complications
0.000 0.444 0.556
E13.4 With neurological complications
0.000 0.444 0.556
E13.3 With ophthalmic complications
0.000 0.444 0.556
E13.2 With renal complications
0.000 0.444 0.556
E13.1 With ketoacidosis
0.000 0.444 0.556
E13.0 With coma
0.000 0.444 0.556
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.444 0.556
E10.9 Without complications
0.000 0.447 0.553
E55 Vitamin D deficiency
0.000 0.455 0.545
K90.9 Intestinal malabsorption, unspecified
0.000 0.461 0.539
D80-D89 Certain disorders involving the immune mechanism
0.000 0.464 0.536
D86.8 Sarcoidosis of other and combined sites
0.000 0.465 0.535
E14.5 With peripheral circulatory complications
0.000 0.466 0.534
E10.6 With other specified complications
0.000 0.467 0.533
E14.7 With multiple complications
0.000 0.474 0.525
E14.2 Withrenal complications
0.000 0.474 0.525
E14.0 With coma
0.000 0.474 0.525
E11.0 With coma
0.000 0.478 0.522
E14.6 With other specified complications
0.000 0.480 0.520
E14.1 With ketoacidosis
0.000 0.484 0.516
L40 Psoriasis
0.000 0.484 0.516
E83.1 Disorders of iron metabolism
0.000 0.488 0.512
E55.9 Vitamin D deficiency, unspecified
0.000 0.490 0.510
K90.8 Other intestinal malabsorption
0.000 0.493 0.507
D86.1 Sarcoidosis of lymph nodes
0.000 0.496 0.504
E15 Nondiabetic hypoglycaemic coma
0.000 0.502 0.498
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.504 0.496
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.504 0.496
E16.4 Abnormal secretion of gastrin
0.000 0.504 0.496
E16.3 Increased secretion of glucagon
0.000 0.504 0.496
D86.0 Sarcoidosis of lung
0.000 0.505 0.495
E53 Deficiency of other B group vitamins
0.000 0.516 0.484
L40.5 Arthropathic psoriasis
0.000 0.516 0.484
E70-E90 Metabolic disorders
0.000 0.518 0.482
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.523 0.477
E83 Disorders of mineral metabolism
0.000 0.525 0.475
D80 Immunodeficiency with predominantly antibody defects
0.000 0.526 0.474
E16.1 Other hypoglycaemia
0.000 0.527 0.473
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.527 0.473
E11.3 With ophthalmic complications
0.000 0.528 0.472
K90.3 Pancreatic steatorrhoea
0.000 0.529 0.471
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.529 0.471
K90.1 Tropical sprue
0.000 0.529 0.471
D75 Other diseases of blood and blood-forming organs
0.000 0.531 0.469
E11.2 With renal complications
0.000 0.532 0.468
E10.5 With peripheral circulatory complications
0.000 0.533 0.467
D70 Agranulocytosis
0.000 0.533 0.467
D86.3 Sarcoidosis of skin
0.000 0.535 0.465
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.548 0.452
E85 Amyloidosis
0.000 0.548 0.452
E40-E46 Malnutrition
0.000 0.549 0.451
E20-E35 Disorders of other endocrine glands
0.000 0.552 0.448
L40.0 Psoriasis vulgaris
0.000 0.556 0.444
E88 Other metabolic disorders
0.000 0.567 0.433
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.569 0.431
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.572 0.428
D75.1 Secondary polycythaemia
0.000 0.572 0.428
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.573 0.426
E63 Other nutritional deficiencies
0.000 0.573 0.426
E56 Other vitamin deficiencies
0.000 0.573 0.426
E50 Vitamin A deficiency
0.000 0.573 0.426
E60 Dietary zinc deficiency
0.000 0.573 0.426
E59 Dietary selenium deficiency
0.000 0.573 0.426
E54 Ascorbic acid deficiency
0.000 0.573 0.426
E52 Niacin deficiency [pellagra]
0.000 0.573 0.426
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.579 0.421
E51 Thiamine deficiency
0.000 0.580 0.420
E34 Other endocrine disorders
0.000 0.581 0.419
E12.9 Without complications
0.000 0.586 0.414
E12.8 With unspecified complications
0.000 0.586 0.414
E12.7 With multiple complications
0.000 0.586 0.414
E12.6 With other specified complications
0.000 0.586 0.414
E12.5 With peripheral circulatory complications
0.000 0.586 0.414
E12.4 With neurological complications
0.000 0.586 0.414
E12.3 With ophthalmic complications
0.000 0.586 0.414
E12.2 With renal complications
0.000 0.586 0.414
E12.1 With ketoacidosis
0.000 0.586 0.414
E12.0 With coma
0.000 0.586 0.414
E03.5 Myxoedema coma
0.369 0.586 0.045
E03.4 Atrophy of thyroid (acquired)
0.369 0.586 0.045
E03.3 Postinfectious hypothyroidism
0.369 0.586 0.045
E03.0 Congenital hypothyroidism with diffuse goitre
0.369 0.586 0.045
E03.1 Congenital hypothyroidism without goitre
0.367 0.589 0.044
D83 Common variable immunodeficiency
0.000 0.600 0.400
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.600 0.400
E53.8 Deficiency of other specified B group vitamins
0.000 0.601 0.399
E03.8 Other specified hypothyroidism
0.360 0.601 0.038
E85.4 Organ-limited amyloidosis
0.000 0.602 0.398
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.353 0.604 0.043
E55.0 Rickets, active
0.000 0.609 0.391
E00-E07 Disorders of thyroid gland
0.202 0.611 0.187
E65-E68 Obesity and other hyperalimentation
0.000 0.611 0.389
E58 Dietary calcium deficiency
0.000 0.614 0.386
D75.2 Essential thrombocytosis
0.000 0.615 0.385
D81 Combined immunodeficiencies
0.000 0.615 0.384
E85.9 Amyloidosis, unspecified
0.000 0.624 0.376
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.628 0.372
L40.8 Other psoriasis
0.000 0.629 0.371
L40.4 Guttate psoriasis
0.000 0.630 0.370
L40.3 Pustulosis palmaris et plantaris
0.000 0.630 0.370
L40.2 Acrodermatitis continua
0.000 0.630 0.370
L40.1 Generalised pustular psoriasis
0.000 0.630 0.370
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.630 0.370
E34.0 Carcinoid syndrome
0.000 0.630 0.370
E29 Testicular dysfunction
0.000 0.630 0.369
E85.3 Secondary systemic amyloidosis
0.000 0.635 0.365
D72 Other disorders of white blood cells
0.000 0.636 0.364
E34.9 Endocrine disorder, unspecified
0.000 0.638 0.362
D82 Immunodeficiency associated with other major defects
0.000 0.640 0.360
E53.9 Vitamin B deficiency, unspecified
0.000 0.643 0.357
E53.1 Pyridoxine deficiency
0.000 0.653 0.347
E53.0 Riboflavin deficiency
0.000 0.653 0.347
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.653 0.347
E77 Disorders of glycoprotein metabolism
0.000 0.654 0.346
E76 Disorders of glycosaminoglycan metabolism
0.000 0.654 0.346
E72 Other disorders of amino-acid metabolism
0.000 0.654 0.346
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.654 0.346
E70 Disorders of aromatic amino-acid metabolism
0.000 0.654 0.346
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.654 0.346
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.655 0.345
D84 Other immunodeficiencies
0.000 0.655 0.345
E79 Disorders of purine and pyrimidine metabolism
0.000 0.656 0.344
E27 Other disorders of adrenal gland
0.000 0.657 0.343
D74 Methaemoglobinaemia
0.000 0.658 0.342
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.658 0.342
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.658 0.342
E84 Cystic fibrosis
0.000 0.659 0.341
E20 Hypoparathyroidism
0.000 0.659 0.341
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.659 0.341
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.659 0.340
E83.8 Other disorders of mineral metabolism
0.000 0.659 0.340
E83.2 Disorders of zinc metabolism
0.000 0.659 0.340
E83.0 Disorders of copper metabolism
0.000 0.659 0.340
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.660 0.340
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.660 0.340
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.660 0.340
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.660 0.340
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.660 0.340
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.660 0.340
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.660 0.340
E22 Hyperfunction of pituitary gland
0.000 0.661 0.339
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.662 0.337
D75.0 Familial erythrocytosis
0.000 0.664 0.336
E34.8 Other specified endocrine disorders
0.000 0.667 0.333
D55-D59 Haemolytic anaemias
0.000 0.669 0.331
E85.8 Other amyloidosis
0.000 0.676 0.324
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.676 0.324
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.676 0.324
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.676 0.324
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.676 0.324
E45 Retarded development following protein-energy malnutrition
0.000 0.676 0.324
E43 Unspecified severe protein-energy malnutrition
0.000 0.676 0.324
E42 Marasmic kwashiorkor
0.000 0.676 0.324
E41 Nutritional marasmus
0.000 0.676 0.324
E40 Kwashiorkor
0.000 0.676 0.324
E88.2 Lipomatosis, not elsewhere classified
0.000 0.677 0.323
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.679 0.321
E32 Diseases of thymus
0.000 0.679 0.321
E31 Polyglandular dysfunction
0.000 0.679 0.321
E30 Disorders of puberty, not elsewhere classified
0.000 0.679 0.321
E25 Adrenogenital disorders
0.000 0.679 0.321
D50-D53 Nutritional anaemias
0.000 0.681 0.319
E88.3 Tumour lysis syndrome
0.000 0.682 0.318
E27.1 Primary adrenocortical insufficiency
0.000 0.684 0.316
E29.1 Testicular hypofunction
0.000 0.687 0.313
E74 Other disorders of carbohydrate metabolism
0.000 0.688 0.312
E88.9 Metabolic disorder, unspecified
0.000 0.689 0.311
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.689 0.311
D72.8 Other specified disorders of white blood cells
0.000 0.691 0.309
E50.9 Vitamin A deficiency, unspecified
0.000 0.694 0.306
E50.8 Other manifestations of vitamin A deficiency
0.000 0.694 0.306
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.694 0.306
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.694 0.306
E50.5 Vitamin A deficiency with night blindness
0.000 0.694 0.306
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.694 0.306
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.694 0.306
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.694 0.306
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.694 0.306
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.694 0.306
E56.9 Vitamin deficiency, unspecified
0.000 0.694 0.306
E56.8 Deficiency of other vitamins
0.000 0.694 0.306
E56.1 Deficiency of vitamin K
0.000 0.694 0.306
E56.0 Deficiency of vitamin E
0.000 0.694 0.306
E63.9 Nutritional deficiency, unspecified
0.000 0.694 0.306
E63.8 Other specified nutritional deficiencies
0.000 0.694 0.306
E63.1 Imbalance of constituents of food intake
0.000 0.694 0.306
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.694 0.306
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.694 0.306
E64.8 Sequelae of other nutritional deficiencies
0.000 0.694 0.306
E64.3 Sequelae of rickets
0.000 0.694 0.306
E64.2 Sequelae of vitamin C deficiency
0.000 0.694 0.306
E64.1 Sequelae of vitamin A deficiency
0.000 0.694 0.306
E64.0 Sequelae of protein-energy malnutrition
0.000 0.694 0.306
E24 Cushing's syndrome
0.000 0.696 0.304
D83.9 Common variable immunodeficiency, unspecified
0.000 0.698 0.302
D51 Vitamin B12 deficiency anaemia
0.000 0.698 0.302
E51.9 Thiamine deficiency, unspecified
0.000 0.699 0.301
E51.8 Other manifestations of thiamine deficiency
0.000 0.699 0.301
E51.1 Beriberi
0.000 0.699 0.301
E34.5 Androgen resistance syndrome
0.000 0.700 0.300
E34.4 Constitutional tall stature
0.000 0.700 0.300
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.700 0.300
E34.1 Other hypersecretion of intestinal hormones
0.000 0.700 0.300
E51.2 Wernicke's encephalopathy
0.000 0.705 0.295
E61 Deficiency of other nutrient elements
0.000 0.707 0.292
E07 Other disorders of thyroid
0.185 0.710 0.105
D83.8 Other common variable immunodeficiencies
0.000 0.713 0.287
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.713 0.287
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.713 0.287
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.713 0.287
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.714 0.286
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.716 0.284
E88.8 Other specified metabolic disorders
0.000 0.718 0.281
E22.1 Hyperprolactinaemia
0.000 0.720 0.280
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.145 0.721 0.134
E00 Congenital iodine-deficiency syndrome
0.145 0.721 0.134
E67 Other hyperalimentation
0.000 0.721 0.279
E68 Sequelae of hyperalimentation
0.000 0.721 0.279
D81.9 Combined immunodeficiency, unspecified
0.000 0.724 0.276
D81.8 Other combined immunodeficiencies
0.000 0.724 0.276
D81.7 Major histocompatibility complex class II deficiency
0.000 0.724 0.276
D81.6 Major histocompatibility complex class I deficiency
0.000 0.724 0.276
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.724 0.276
D81.4 Nezelof's syndrome
0.000 0.724 0.276
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.724 0.276
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.724 0.276
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.724 0.276
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.724 0.276
E46 Unspecified protein-energy malnutrition
0.000 0.727 0.273
E02 Subclinical iodine-deficiency hypothyroidism
0.157 0.728 0.115
E34.3 Short stature, not elsewhere classified
0.000 0.729 0.271
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.732 0.268
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.735 0.265
D89.3 Immune reconstitution syndrome
0.000 0.735 0.265
D59 Acquired haemolytic anaemia
0.000 0.735 0.265
E29.9 Testicular dysfunction, unspecified
0.000 0.735 0.265
E29.8 Other testicular dysfunction
0.000 0.735 0.265
E29.0 Testicular hyperfunction
0.000 0.735 0.265
E22.0 Acromegaly and pituitary gigantism
0.000 0.735 0.264
E20.9 Hypoparathyroidism, unspecified
0.000 0.736 0.264
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.736 0.263
D72.9 Disorder of white blood cells, unspecified
0.000 0.739 0.261
D72.0 Genetic anomalies of leukocytes
0.000 0.739 0.261
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.741 0.258
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.741 0.258
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.741 0.258
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.741 0.258
D82.2 Immunodeficiency with short-limbed stature
0.000 0.741 0.258
D82.0 Wiskott-Aldrich syndrome
0.000 0.741 0.258
E23 Hypofunction and other disorders of pituitary gland
0.000 0.744 0.256
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.744 0.256
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.749 0.251
E65 Localised adiposity
0.000 0.750 0.250
E73 Lactose intolerance
0.001 0.750 0.250
E75.5 Other lipid storage disorders
0.000 0.750 0.250
E14.9 Without complications
0.000 0.751 0.249
E75.6 Lipid storage disorder, unspecified
0.000 0.751 0.249
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.751 0.249
E75.3 Sphingolipidosis, unspecified
0.000 0.751 0.249
E75.2 Other sphingolipidosis
0.000 0.751 0.249
E75.1 Other gangliosidosis
0.000 0.751 0.249
E75.0 GM2 gangliosidosis
0.000 0.751 0.249
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.752 0.248
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.752 0.248
E70.3 Albinism
0.000 0.752 0.248
E70.2 Disorders of tyrosine metabolism
0.000 0.752 0.248
E70.1 Other hyperphenylalaninaemias
0.000 0.752 0.248
E70.0 Classical phenylketonuria
0.000 0.752 0.248
E71.3 Disorders of fatty-acid metabolism
0.000 0.752 0.248
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.752 0.248
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.752 0.248
E71.0 Maple-syrup-urine disease
0.000 0.752 0.248
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.752 0.248
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.752 0.248
E72.5 Disorders of glycine metabolism
0.000 0.752 0.248
E72.4 Disorders of ornithine metabolism
0.000 0.752 0.248
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.752 0.248
E72.2 Disorders of urea cycle metabolism
0.000 0.752 0.248
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.752 0.248
E72.0 Disorders of amino-acid transport
0.000 0.752 0.248
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.752 0.248
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.752 0.248
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.752 0.248
E76.2 Other mucopolysaccharidoses
0.000 0.752 0.248
E76.1 Mucopolysaccharidosis, type II
0.000 0.752 0.248
E76.0 Mucopolysaccharidosis, type I
0.000 0.752 0.248
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.752 0.248
E77.8 Other disorders of glycoprotein metabolism
0.000 0.752 0.248
E77.1 Defects in glycoprotein degradation
0.000 0.752 0.248
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.752 0.248
D84.8 Other specified immunodeficiencies
0.000 0.752 0.247
D84.1 Defects in the complement system
0.000 0.752 0.247
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.752 0.247
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.753 0.246
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.753 0.246
E79.1 Lesch-Nyhan syndrome
0.000 0.753 0.246
E27.5 Adrenomedullary hyperfunction
0.000 0.754 0.246
E27.0 Other adrenocortical overactivity
0.000 0.754 0.246
D74.9 Methaemoglobinaemia, unspecified
0.000 0.755 0.245
D74.8 Other methaemoglobinaemias
0.000 0.755 0.245
D74.0 Congenital methaemoglobinaemia
0.000 0.755 0.245
E84.8 Cystic fibrosis with other manifestations
0.000 0.755 0.245
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.755 0.245
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.755 0.245
E20.8 Other hypoparathyroidism
0.000 0.755 0.244
E20.1 Pseudohypoparathyroidism
0.000 0.755 0.244
E20.0 Idiopathic hypoparathyroidism
0.000 0.755 0.244
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.756 0.244
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.757 0.243
E22.8 Other hyperfunction of pituitary gland
0.000 0.757 0.243
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.758 0.242
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.758 0.242
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.758 0.242
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.758 0.242
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.759 0.241
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.760 0.240
E84.9 Cystic fibrosis, unspecified
0.000 0.760 0.240
D76.3 Other histiocytosis syndromes
0.000 0.762 0.238
D57 Sickle-cell disorders
0.000 0.763 0.237
D55 Anaemia due to enzyme disorders
0.000 0.763 0.237
E06 Thyroiditis
0.152 0.763 0.085
D58 Other hereditary haemolytic anaemias
0.000 0.764 0.235
D82.1 Di George's syndrome
0.000 0.766 0.234
E26 Hyperaldosteronism
0.000 0.766 0.233
E44.1 Mild protein-energy malnutrition
0.000 0.768 0.232
E44.0 Moderate protein-energy malnutrition
0.000 0.768 0.232
E25.9 Adrenogenital disorder, unspecified
0.000 0.769 0.230
E25.8 Other adrenogenital disorders
0.000 0.769 0.230
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.769 0.230
E30.9 Disorder of puberty, unspecified
0.000 0.769 0.230
E30.8 Other disorders of puberty
0.000 0.769 0.230
E30.1 Precocious puberty
0.000 0.769 0.230
E30.0 Delayed puberty
0.000 0.769 0.230
E31.9 Polyglandular dysfunction, unspecified
0.000 0.769 0.230
E31.8 Other polyglandular dysfunction
0.000 0.769 0.230
E31.1 Polyglandular hyperfunction
0.000 0.769 0.230
E31.0 Autoimmune polyglandular failure
0.000 0.769 0.230
E32.9 Disease of thymus, unspecified
0.000 0.769 0.230
E32.8 Other diseases of thymus
0.000 0.769 0.230
E32.1 Abscess of thymus
0.000 0.769 0.230
E32.0 Persistent hyperplasia of thymus
0.000 0.769 0.230
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.769 0.230
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.769 0.230
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.769 0.230
D89.1 Cryoglobulinaemia
0.000 0.775 0.224
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.776 0.224
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.776 0.224
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.776 0.224
E74.2 Disorders of galactose metabolism
0.000 0.776 0.224
E74.1 Disorders of fructose metabolism
0.000 0.776 0.224
E74.0 Glycogen storage disease
0.000 0.776 0.224
K90-K93 Other diseases of the digestive system
0.000 0.776 0.224
E27.2 Addisonian crisis
0.000 0.777 0.223
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.779 0.221
D53 Other nutritional anaemias
0.000 0.780 0.219
E24.8 Other Cushing's syndrome
0.000 0.782 0.218
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.782 0.218
E24.3 Ectopic ACTH syndrome
0.000 0.782 0.218
E24.1 Nelson's syndrome
0.000 0.782 0.218
E24.0 Pituitary-dependent Cushing's disease
0.000 0.782 0.218
D59.1 Other autoimmune haemolytic anaemias
0.000 0.782 0.218
E23.6 Other disorders of pituitary gland
0.000 0.782 0.218
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.783 0.217
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.783 0.217
D51.2 Transcobalamin II deficiency
0.000 0.783 0.217
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.783 0.217
E24.9 Cushing's syndrome, unspecified
0.000 0.784 0.216
E66 Obesity
0.000 0.788 0.212
D72.1 Eosinophilia
0.000 0.789 0.211
E61.9 Deficiency of nutrient element, unspecified
0.000 0.790 0.210
E61.8 Deficiency of other specified nutrient elements
0.000 0.790 0.210
E61.7 Deficiency of multiple nutrient elements
0.000 0.790 0.210
E61.6 Vanadium deficiency
0.000 0.790 0.210
E61.5 Molybdenum deficiency
0.000 0.790 0.210
E61.4 Chromium deficiency
0.000 0.790 0.210
E61.3 Manganese deficiency
0.000 0.790 0.210
E61.0 Copper deficiency
0.000 0.790 0.210
E07.1 Dyshormogenetic goitre
0.133 0.792 0.075
E07.0 Hypersecretion of calcitonin
0.133 0.792 0.075
D84.9 Immunodeficiency, unspecified
0.000 0.792 0.207
D66 Hereditary factor VIII deficiency
0.000 0.795 0.205
E27.9 Disorder of adrenal gland, unspecified
0.000 0.796 0.204
E24.2 Drug-induced Cushing's syndrome
0.000 0.796 0.204
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.104 0.800 0.096
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.104 0.800 0.096
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.104 0.800 0.096
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.104 0.800 0.096
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.104 0.800 0.096
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.104 0.800 0.096
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.104 0.800 0.096
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.104 0.800 0.096
E67.8 Other specified hyperalimentation
0.000 0.800 0.200
E67.3 Hypervitaminosis D
0.000 0.800 0.200
E67.2 Megavitamin-B6 syndrome
0.000 0.800 0.200
E67.1 Hypercarotenaemia
0.000 0.800 0.200
E67.0 Hypervitaminosis A
0.000 0.800 0.200
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.802 0.198
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.810 0.190
D59.8 Other acquired haemolytic anaemias
0.000 0.810 0.190
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.810 0.190
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.810 0.190
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.810 0.190
D59.3 Haemolytic-uraemic syndrome
0.000 0.810 0.190
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.810 0.190
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.810 0.190
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.810 0.190
E07.9 Disorder of thyroid, unspecified
0.179 0.810 0.011
E05 Thyrotoxicosis [hyperthyroidism]
0.020 0.810 0.170
D56 Thalassaemia
0.000 0.811 0.188
E61.2 Magnesium deficiency
0.000 0.813 0.187
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.816 0.184
E23.1 Drug-induced hypopituitarism
0.000 0.816 0.184
E66.0 Obesity due to excess calories
0.000 0.818 0.182
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.818 0.182
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.000 0.819 0.181
E07.8 Other specified disorders of thyroid
0.093 0.820 0.087
E73.8 Other lactose intolerance
0.001 0.820 0.179
E73.1 Secondary lactase deficiency
0.001 0.820 0.179
E73.0 Congenital lactase deficiency
0.001 0.820 0.179
E89.3 Postprocedural hypopituitarism
0.000 0.821 0.179
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.822 0.178
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.822 0.178
E06.1 Subacute thyroiditis
0.127 0.825 0.048
E80.2 Other porphyria
0.000 0.825 0.174
D67 Hereditary factor IX deficiency
0.000 0.826 0.173
E06.5 Other chronic thyroiditis
0.122 0.827 0.051
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.827 0.172
E80.5 Crigler-Najjar syndrome
0.000 0.827 0.172
E80.3 Defects of catalase and peroxydase
0.000 0.827 0.172
E80.1 Porphyria cutanea tarda
0.000 0.827 0.172
E80.0 Hereditary erythropoietic porphyria
0.000 0.827 0.172
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.830 0.170
D55.8 Other anaemias due to enzyme disorders
0.000 0.830 0.170
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.830 0.170
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.830 0.170
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.830 0.170
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.830 0.170
D57.8 Other sickle-cell disorders
0.000 0.830 0.170
D57.3 Sickle-cell trait
0.000 0.830 0.170
D57.2 Double heterozygous sickling disorders
0.000 0.830 0.170
D57.1 Sickle-cell anaemia without crisis
0.000 0.830 0.170
D57.0 Sickle-cell anaemia with crisis
0.000 0.830 0.170
E06.4 Drug-induced thyroiditis
0.109 0.830 0.061
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.109 0.830 0.061
E06.0 Acute thyroiditis
0.109 0.830 0.061
E27.8 Other specified disorders of adrenal gland
0.000 0.830 0.170
E89.2 Postprocedural hypoparathyroidism
0.000 0.831 0.169
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.831 0.169
D58.2 Other haemoglobinopathies
0.000 0.831 0.169
D58.1 Hereditary elliptocytosis
0.000 0.831 0.169
D58.0 Hereditary spherocytosis
0.000 0.832 0.168
E23.7 Disorder of pituitary gland, unspecified
0.000 0.832 0.168
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.832 0.168
E26.8 Other hyperaldosteronism
0.000 0.832 0.167
E26.1 Secondary hyperaldosteronism
0.000 0.832 0.167
E83.5 Disorders of calcium metabolism
0.000 0.833 0.167
D73 Diseases of spleen
0.000 0.836 0.164
K91.2 Postsurgical malabsorption, not elsewhere classified
0.000 0.836 0.164
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.839 0.160
E05.0 Thyrotoxicosis with diffuse goitre
0.002 0.840 0.158
K91.0 Vomiting following gastro-intestinal surgery
0.000 0.840 0.160

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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