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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs9271425
log Bayes Factor = 129.757
Chromosome 6   position 32,587,923  (GRCh37) Explore rs9271425 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
H30-H36 Disorders of choroid and retina
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
N00-N08 Glomerular diseases
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
E10.1 With ketoacidosis
1.000 0.000 0.000
D60-D64 Aplastic and other anaemias
1.000 0.000 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
1.000 0.000 0.000
M35 Other systemic involvement of connective tissue
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
1.000 0.000 0.000
M35.0 Sicca syndrome [Sjogren]
1.000 0.000 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
1.000 0.000 0.000
E20-E35 Disorders of other endocrine glands
1.000 0.000 0.000
E14 Unspecified diabetes mellitus
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
M15-M19 Arthrosis
1.000 0.000 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
N17-N19 Renal failure
1.000 0.000 0.000
N18 Chronic renal failure
0.999 0.001 0.000
M05 Seropositive rheumatoid arthritis
0.000 0.001 0.999
M18 Arthrosis of first carpometacarpal joint
0.999 0.001 0.000
D69 Purpura and other haemorrhagic conditions
0.999 0.001 0.000
E27 Other disorders of adrenal gland
0.999 0.001 0.000
M05-M14 Inflammatory polyarthropathies
0.000 0.001 0.999
D64 Other anaemias
0.999 0.001 0.000
E27.1 Primary adrenocortical insufficiency
0.999 0.001 0.000
H36 Retinal disorders in diseases classified elsewhere
0.999 0.001 0.000
M24 Other specific joint derangements
0.999 0.001 0.000
D64.9 Anaemia, unspecified
0.999 0.001 0.000
N04 Nephrotic syndrome
0.999 0.001 0.000
H36.0 Diabetic retinopathy
0.998 0.002 0.000
L40.9 Psoriasis, unspecified
0.000 0.002 0.998
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.998 0.002 0.000
N05 Unspecified nephritic syndrome
0.997 0.003 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.996 0.004 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.996 0.004 0.000
Chapter IX Diseases of the circulatory system
0.996 0.004 0.000
M24.1 Other articular cartilage disorders
0.996 0.004 0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.995 0.005 0.000
D50-D53 Nutritional anaemias
0.995 0.005 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.994 0.006 0.000
N04.9 Unspecified
0.993 0.007 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.993 0.007 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.993 0.007 0.000
Q60-Q64 Congenital malformations of the urinary system
0.992 0.008 0.000
H06.2 Dysthyroid exophthalmos
0.992 0.008 0.000
I10-I15 Hypertensive diseases
0.992 0.008 0.000
D69.6 Thrombocytopenia, unspecified
0.992 0.008 0.000
I12 Hypertensive renal disease
0.992 0.008 0.000
H34 Retinal vascular occlusions
0.992 0.008 0.000
E14.9 Without complications
0.991 0.009 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.010 0.990
M06.3 Rheumatoid nodule
0.000 0.012 0.988
D80-D89 Certain disorders involving the immune mechanism
0.986 0.014 0.000
H34.8 Other retinal vascular occlusions
0.986 0.014 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.015 0.985
Q38-Q45 Other congenital malformations of the digestive system
0.983 0.017 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.017 0.983
I12.0 Hypertensive renal disease with renal failure
0.981 0.019 0.000
E14.3 With ophthalmic complications
0.979 0.021 0.000
D50 Iron deficiency anaemia
0.979 0.021 0.000
I12.9 Hypertensive renal disease without renal failure
0.978 0.022 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.975 0.025 0.000
Q61 Cystic kidney disease
0.975 0.025 0.000
E10.4 With neurological complications
0.973 0.027 0.000
E10.2 With renal complications
0.972 0.028 0.000
N05.2 Diffuse membranous glomerulonephritis
0.970 0.030 0.000
I77 Other disorders of arteries and arterioles
0.970 0.030 0.000
D61 Other aplastic anaemias
0.968 0.032 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.033 0.967
D69.3 Idiopathic thrombocytopenic purpura
0.966 0.034 0.000
E89.0 Postprocedural hypothyroidism
0.962 0.038 0.000
D50.9 Iron deficiency anaemia, unspecified
0.962 0.038 0.000
D86 Sarcoidosis
0.961 0.039 0.000
H35 Other retinal disorders
0.960 0.040 0.000
H33 Retinal detachments and breaks
0.959 0.041 0.000
D68 Other coagulation defects
0.959 0.041 0.000
E28 Ovarian dysfunction
0.958 0.042 0.000
N18.9 Chronic renal failure, unspecified
0.957 0.043 0.000
N18.3 Chronic kidney disease, stage 3
0.956 0.044 0.000
M86-M90 Other osteopathies
0.954 0.046 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.953 0.047 0.000
E70-E90 Metabolic disorders
0.953 0.047 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.050 0.950
I74 Arterial embolism and thrombosis
0.949 0.051 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.948 0.052 0.000
N05.9 Unspecified
0.946 0.054 0.000
D61.9 Aplastic anaemia, unspecified
0.946 0.054 0.000
M06.34 Rheumatoid nodule (Hand)
0.000 0.054 0.946
M21 Other acquired deformities of limbs
0.945 0.055 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.055 0.944
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.060 0.940
Q43 Other congenital malformations of intestine
0.938 0.062 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.937 0.063 0.000
M21.0 Valgus deformity, not elsewhere classified
0.936 0.064 0.000
M15 Polyarthrosis
0.934 0.066 0.000
N18.5 Chronic kidney disease, stage 5
0.934 0.066 0.000
Q61.3 Polycystic kidney, unspecified
0.932 0.068 0.000
H02 Other disorders of eyelid
0.932 0.068 0.000
I71 Aortic aneurysm and dissection
0.932 0.068 0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.930 0.070 0.000
M60-M63 Disorders of muscles
0.929 0.071 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.928 0.072 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.928 0.072 0.000
N17 Acute renal failure
0.928 0.072 0.000
M17 Gonarthrosis [arthrosis of knee]
0.927 0.073 0.000
H33.1 Retinoschisis and retinal cysts
0.923 0.077 0.000
H43-H45 Disorders of vitreous body and globe
0.920 0.080 0.000
H33.4 Traction detachment of retina
0.918 0.082 0.000
M32 Systemic lupus erythematosus
0.915 0.085 0.000
D68.8 Other specified coagulation defects
0.915 0.085 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.913 0.087 0.000
H50 Other strabismus
0.913 0.087 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.913 0.087 0.000
M17.1 Other primary gonarthrosis
0.913 0.087 0.000
N08.5 Glomerular disorders in systemic connective tissue disorders
0.912 0.088 0.000
M07 Psoriatic and enteropathic arthropathies
0.000 0.092 0.908
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.094 0.906
M35.7 Hypermobility syndrome
0.906 0.094 0.000
D51 Vitamin B12 deficiency anaemia
0.904 0.096 0.000
H02.0 Entropion and trichiasis of eyelid
0.901 0.099 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.901 0.099 0.000
H35.8 Other specified retinal disorders
0.896 0.104 0.000
H43 Disorders of vitreous body
0.896 0.104 0.000
N25-N29 Other disorders of kidney and ureter
0.894 0.106 0.000
N18.0 End-stage renal disease
0.894 0.106 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.893 0.107 0.000
N17.9 Acute renal failure, unspecified
0.892 0.108 0.000
N04.2 Diffuse membranous glomerulonephritis
0.892 0.108 0.000
H02.5 Other disorders affecting eyelid function
0.890 0.110 0.000
H00.1 Chalazion
0.000 0.110 0.890
E10.0 With coma
0.889 0.111 0.000
I77.1 Stricture of artery
0.888 0.112 0.000
I73 Other peripheral vascular diseases
0.888 0.112 0.000
E24 Cushing's syndrome
0.887 0.113 0.000
H02.6 Xanthelasma of eyelid
0.887 0.113 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.887 0.113 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.886 0.114 0.000
Q61.2 Polycystic kidney, adult type
0.880 0.120 0.000
M34 Systemic sclerosis
0.879 0.121 0.000
N18.2 Chronic kidney disease, stage 2
0.878 0.122 0.000
E14.8 With unspecified complications
0.877 0.123 0.000
N04.1 Focal and segmental glomerular lesions
0.876 0.124 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.876 0.124 0.000
E28.2 Polycystic ovarian syndrome
0.876 0.124 0.000
H43.8 Other disorders of vitreous body
0.874 0.126 0.000
H35.4 Peripheral retinal degeneration
0.872 0.128 0.000
N05.5 Diffuse mesangiocapillary glomerulonephritis
0.871 0.129 0.000
H35.0 Background retinopathy and retinal vascular changes
0.870 0.130 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.133 0.867
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.866 0.134 0.000
L40 Psoriasis
0.002 0.134 0.864
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.866 0.134 0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)
0.863 0.137 0.000
E28.3 Primary ovarian failure
0.860 0.140 0.000
N18.4 Chronic kidney disease, stage 4
0.859 0.141 0.000
D86.3 Sarcoidosis of skin
0.859 0.141 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.144 0.856
D69.4 Other primary thrombocytopenia
0.856 0.144 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.856 0.144 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.855 0.145 0.000
Q00-Q07 Congenital malformations of the nervous system
0.855 0.145 0.000
D86.9 Sarcoidosis, unspecified
0.854 0.146 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.849 0.151 0.000
Q60.0 Renal agenesis, unilateral
0.846 0.154 0.000
D86.0 Sarcoidosis of lung
0.846 0.154 0.000
M22 Disorders of patella
0.845 0.155 0.000
M86 Osteomyelitis
0.845 0.155 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.844 0.156 0.000
M07.3 Other psoriatic arthropathies
0.000 0.157 0.843
L40.5 Arthropathic psoriasis
0.000 0.157 0.843
D50.8 Other iron deficiency anaemias
0.843 0.157 0.000
E83.1 Disorders of iron metabolism
0.000 0.160 0.839
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.839 0.161 0.000
M60 Myositis
0.838 0.162 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.837 0.163 0.000
N05.1 Focal and segmental glomerular lesions
0.837 0.163 0.000
N28.9 Disorder of kidney and ureter, unspecified
0.837 0.163 0.000
M15.2 Bouchard's nodes (with arthropathy)
0.835 0.165 0.000
E03.8 Other specified hypothyroidism
0.834 0.166 0.000
M35.1 Other overlap syndromes
0.830 0.170 0.000
Q44.6 Cystic disease of liver
0.830 0.170 0.000
D68.6 Other Thrombophilia
0.828 0.172 0.000
Q43.9 Congenital malformation of intestine, unspecified
0.824 0.176 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.817 0.183 0.000
Q43.0 Meckel's diverticulum
0.814 0.186 0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.811 0.189 0.000
M15.1 Heberden's nodes (with arthropathy)
0.811 0.189 0.000
E73 Lactose intolerance
0.809 0.191 0.000
H50.5 Heterophoria
0.808 0.192 0.000
D52 Folate deficiency anaemia
0.807 0.193 0.000
I73.9 Peripheral vascular disease, unspecified
0.804 0.196 0.000
H43.1 Vitreous haemorrhage
0.803 0.197 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.197 0.803
D68.2 Hereditary deficiency of other clotting factors
0.802 0.198 0.000
Q63 Other congenital malformations of kidney
0.801 0.199 0.000
E16.1 Other hypoglycaemia
0.801 0.199 0.000
M87 Osteonecrosis
0.799 0.201 0.000
H35.2 Other proliferative retinopathy
0.796 0.204 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.205 0.795
H35.6 Retinal haemorrhage
0.794 0.206 0.000
E31 Polyglandular dysfunction
0.792 0.208 0.000
Chapter XX External causes of morbidity and mortality
0.790 0.210 0.000
D80 Immunodeficiency with predominantly antibody defects
0.790 0.210 0.000
H50.1 Divergent concomitant strabismus
0.786 0.214 0.000
H05 Disorders of orbit
0.786 0.214 0.000
D69.8 Other specified haemorrhagic conditions
0.786 0.214 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.785 0.215 0.000
E10.5 With peripheral circulatory complications
0.785 0.215 0.000
D69.9 Haemorrhagic condition, unspecified
0.783 0.217 0.000
E27.9 Disorder of adrenal gland, unspecified
0.782 0.218 0.000
M62 Other disorders of muscle
0.781 0.219 0.000
Q60.2 Renal agenesis, unspecified
0.780 0.220 0.000
E14.2 Withrenal complications
0.778 0.222 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.224 0.776
Q38 Other congenital malformations of tongue, mouth and pharynx
0.776 0.224 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.224 0.776
Q43.3 Congenital malformations of intestinal fixation
0.773 0.227 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.228 0.772
E24.2 Drug-induced Cushing's syndrome
0.771 0.229 0.000
H50.2 Vertical strabismus
0.771 0.229 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.770 0.230 0.000
E10.7 With multiple complications
0.769 0.231 0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.232 0.768
E10.8 With unspecified complications
0.768 0.232 0.000
M21.8 Other specified acquired deformities of limbs
0.767 0.233 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.766 0.234 0.000
Q35-Q37 Cleft lip and cleft palate
0.766 0.234 0.000
M14 Arthropathies in other diseases classified elsewhere
0.000 0.235 0.765
M60.9 Myositis, unspecified
0.765 0.235 0.000
M24.5 Contracture of joint
0.763 0.237 0.000
D64.8 Other specified anaemias
0.762 0.238 0.000
M22.2 Patellofemoral disorders
0.762 0.238 0.000
M24.2 Disorder of ligament
0.762 0.238 0.000
E40-E46 Malnutrition
0.761 0.238 0.000
H34.9 Retinal vascular occlusion, unspecified
0.761 0.239 0.000
H00 Hordeolum and chalazion
0.194 0.241 0.565
E20 Hypoparathyroidism
0.759 0.241 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.241 0.759
M23 Internal derangement of knee
0.758 0.242 0.000
D50.1 Sideropenic dysphagia
0.757 0.243 0.000
N00 Acute nephritic syndrome
0.757 0.243 0.000
E14.1 With ketoacidosis
0.756 0.244 0.000
Q61.9 Cystic kidney disease, unspecified
0.754 0.246 0.000
D83 Common variable immunodeficiency
0.752 0.247 0.000
I77.2 Rupture of artery
0.752 0.248 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.751 0.249 0.000
I77.0 Arteriovenous fistula, acquired
0.750 0.250 0.000
M89 Other disorders of bone
0.749 0.251 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.749 0.251 0.000
E14.4 With neurological complications
0.748 0.252 0.000
E27.2 Addisonian crisis
0.748 0.252 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.748 0.252 0.000
H50.6 Mechanical strabismus
0.748 0.252 0.000
Q61.0 Congenital single renal cyst
0.747 0.253 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.747 0.253 0.000
E14.5 With peripheral circulatory complications
0.745 0.255 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.745 0.255 0.000
H49 Paralytic strabismus
0.745 0.255 0.000
I74.8 Embolism and thrombosis of other arteries
0.743 0.257 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.743 0.257 0.000
E70 Disorders of aromatic amino-acid metabolism
0.742 0.258 0.000
D86.8 Sarcoidosis of other and combined sites
0.742 0.258 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.741 0.259 0.000
H35.7 Separation of retinal layers
0.740 0.260 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.260 0.740
D69.0 Allergic purpura
0.739 0.261 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.736 0.264 0.000
E24.0 Pituitary-dependent Cushing's disease
0.735 0.265 0.000
E89.4 Postprocedural ovarian failure
0.734 0.266 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.731 0.269 0.000
N18.1 Chronic kidney disease, stage 1
0.731 0.269 0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)
0.731 0.269 0.000
M34.0 Progressive systemic sclerosis
0.731 0.269 0.000
I77.6 Arteritis, unspecified
0.730 0.270 0.000
M24.7 Protrusio acetabuli
0.730 0.270 0.000
M88 Paget's disease of bone [osteitis deformans]
0.729 0.271 0.000
M87.9 Osteonecrosis, unspecified
0.728 0.272 0.000
H30 Chorioretinal inflammation
0.728 0.272 0.000
M22.3 Other derangements of patella
0.727 0.273 0.000
M90 Osteopathies in diseases classified elsewhere
0.726 0.274 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.725 0.275 0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.725 0.275 0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)
0.725 0.275 0.000
D68.5 Primary Thrombophilia
0.723 0.277 0.000
D68.1 Hereditary factor XI deficiency
0.723 0.277 0.000
M35.2 Behcet's disease
0.722 0.278 0.000
M17.0 Primary gonarthrosis, bilateral
0.721 0.279 0.000
M34.1 CR(E)ST syndrome
0.720 0.280 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.720 0.280 0.000
H34.2 Other retinal artery occlusions
0.719 0.281 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.717 0.283 0.000
N07 Hereditary nephropathy, not elsewhere classified
0.717 0.283 0.000
N06 Isolated proteinuria with specified morphological lesion
0.717 0.283 0.000
N01 Rapidly progressive nephritic syndrome
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.717 0.283 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.717 0.283 0.000
E16.4 Abnormal secretion of gastrin
0.717 0.283 0.000
E16.3 Increased secretion of glucagon
0.717 0.283 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.717 0.283 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.717 0.283 0.000
M35.5 Multifocal fibrosclerosis
0.717 0.283 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.717 0.283 0.000
D67 Hereditary factor IX deficiency
0.717 0.283 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.717 0.283 0.000
E32 Diseases of thymus
0.717 0.283 0.000
E30 Disorders of puberty, not elsewhere classified
0.717 0.283 0.000
E25 Adrenogenital disorders
0.717 0.283 0.000
E14.7 With multiple complications
0.717 0.283 0.000
E14.0 With coma
0.717 0.283 0.000
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.716
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.716
M05.2 Rheumatoid vasculitis
0.000 0.283 0.716
M05.1 Rheumatoid lung disease
0.000 0.283 0.716
M05.0 Felty's syndrome
0.000 0.283 0.716
M18.5 Other secondary arthrosis of first carpometacarpal joint
0.717 0.283 0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral
0.717 0.283 0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint
0.717 0.283 0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral
0.717 0.283 0.000
D69.1 Qualitative platelet defects
0.716 0.283 0.000
E27.5 Adrenomedullary hyperfunction
0.716 0.283 0.000
E27.0 Other adrenocortical overactivity
0.716 0.283 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.716
M08 Juvenile arthritis
0.000 0.283 0.716
D64.4 Congenital dyserythropoietic anaemia
0.716 0.283 0.000
D64.3 Other sideroblastic anaemias
0.716 0.283 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.716 0.283 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.716 0.283 0.000
D64.0 Hereditary sideroblastic anaemia
0.716 0.283 0.000
M24.9 Joint derangement, unspecified
0.716 0.284 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.716 0.284 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.284 0.716
N04.8 Other
0.716 0.284 0.000
N04.7 Diffuse crescentic glomerulonephritis
0.716 0.284 0.000
N04.6 Dense deposit disease
0.716 0.284 0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis
0.716 0.284 0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis
0.716 0.284 0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis
0.716 0.284 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.716 0.284 0.000
D68.0 Von Willebrand's disease
0.716 0.284 0.000
N05.6 Dense deposit disease
0.715 0.285 0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis
0.715 0.285 0.000
N05.0 Minor glomerular abnormality
0.715 0.285 0.000
M24.19 Other articular cartilage disorders (Site unspecified)
0.714 0.286 0.000
M24.18 Other articular cartilage disorders (Other)
0.714 0.286 0.000
M24.14 Other articular cartilage disorders (Hand)
0.714 0.286 0.000
M24.12 Other articular cartilage disorders (Upper arm)
0.714 0.286 0.000
M24.10 Other articular cartilage disorders (Multiple sites)
0.714 0.286 0.000
Q40 Other congenital malformations of upper alimentary tract
0.714 0.286 0.000
M60.99 Myositis, unspecified (Site unspecified)
0.713 0.287 0.000
H06.3 Other disorders of orbit in diseases classified elsewhere
0.712 0.288 0.000
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.712 0.288 0.000
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.712 0.288 0.000
N08.8 Glomerular disorders in other diseases classified elsewhere
0.712 0.288 0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism
0.712 0.288 0.000
N08.1 Glomerular disorders in neoplastic diseases
0.712 0.288 0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere
0.712 0.288 0.000
I13 Hypertensive heart and renal disease
0.711 0.289 0.000
H34.0 Transient retinal artery occlusion
0.711 0.289 0.000
D69.2 Other nonthrombocytopenic purpura
0.711 0.289 0.000
M17.5 Other secondary gonarthrosis
0.711 0.289 0.000
I71.0 Dissection of aorta [any part]
0.710 0.290 0.000
I00-I02 Acute rheumatic fever
0.709 0.291 0.000
M86.9 Osteomyelitis, unspecified
0.709 0.291 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.292 0.708
M06.38 Rheumatoid nodule (Other)
0.000 0.292 0.708
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.292 0.708
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.292 0.708
M06.33 Rheumatoid nodule (Forearm)
0.000 0.292 0.708
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.292 0.708
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.292 0.708
D82 Immunodeficiency associated with other major defects
0.707 0.293 0.000
D81 Combined immunodeficiencies
0.707 0.293 0.000
H10-H13 Disorders of conjunctiva
0.707 0.293 0.000
H05.2 Exophthalmic conditions
0.707 0.293 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.294 0.706
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.294 0.706
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.294 0.706
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.294 0.706
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.294 0.706
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.294 0.706
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.294 0.706
E73.9 Lactose intolerance, unspecified
0.706 0.294 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.706 0.294 0.000
Q45 Other congenital malformations of digestive system
0.705 0.295 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.705 0.295 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.705 0.295 0.000
V10-V19 Pedal cyclist injured in transport accident
0.703 0.297 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.702 0.298 0.000
N27 Small kidney of unknown cause
0.702 0.298 0.000
I73.8 Other specified peripheral vascular diseases
0.700 0.300 0.000
E07 Other disorders of thyroid
0.700 0.300 0.000
Q61.8 Other cystic kidney diseases
0.699 0.301 0.000
Q61.4 Renal dysplasia
0.699 0.301 0.000
Q61.1 Polycystic kidney, infantile type
0.699 0.301 0.000
I15 Secondary hypertension
0.698 0.302 0.000
N04.0 Minor glomerular abnormality
0.697 0.303 0.000
M23.8 Other internal derangements of knee
0.696 0.304 0.000
D53 Other nutritional anaemias
0.696 0.304 0.000
I77.5 Necrosis of artery
0.695 0.305 0.000
I77.4 Coeliac artery compression syndrome
0.695 0.305 0.000
I77.3 Arterial fibromuscular dysplasia
0.695 0.305 0.000
M24.17 Other articular cartilage disorders (Ankle and foot)
0.695 0.305 0.000
Q07 Other congenital malformations of nervous system
0.695 0.305 0.000
D61.0 Constitutional aplastic anaemia
0.694 0.305 0.000
D61.8 Other specified aplastic anaemias
0.694 0.306 0.000
D61.3 Idiopathic aplastic anaemia
0.694 0.306 0.000
D61.2 Aplastic anaemia due to other external agents
0.694 0.306 0.000
V40-V49 Car occupant injured in transport accident
0.694 0.306 0.000
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases
0.693 0.307 0.000
N05.8 Other
0.693 0.307 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.308 0.692
I11 Hypertensive heart disease
0.692 0.308 0.000
M22.9 Disorder of patella, unspecified
0.691 0.309 0.000
Q63.2 Ectopic kidney
0.691 0.309 0.000
Q44.5 Other congenital malformations of bile ducts
0.691 0.309 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.691 0.309 0.000
D61.1 Drug-induced aplastic anaemia
0.688 0.312 0.000
H35.1 Retinopathy of prematurity
0.688 0.312 0.000
D68.4 Acquired coagulation factor deficiency
0.687 0.313 0.000
E28.9 Ovarian dysfunction, unspecified
0.687 0.313 0.000
E28.8 Other ovarian dysfunction
0.687 0.313 0.000
E28.1 Androgen excess
0.687 0.313 0.000
E28.0 Oestrogen excess
0.687 0.313 0.000
M21.9 Acquired deformity of limb, unspecified
0.686 0.314 0.000
Y52 Agents primarily affecting the cardiovascular system
0.686 0.314 0.000
I70 Atherosclerosis
0.685 0.314 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.683 0.317 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.683 0.317 0.000
E89.5 Postprocedural testicular hypofunction
0.683 0.317 0.000
E89.1 Postprocedural hypoinsulinaemia
0.683 0.317 0.000
E77 Disorders of glycoprotein metabolism
0.683 0.317 0.000
E76 Disorders of glycosaminoglycan metabolism
0.683 0.317 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.683 0.317 0.000
E72 Other disorders of amino-acid metabolism
0.683 0.317 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.683 0.317 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.683 0.317 0.000
Q05 Spina bifida
0.682 0.318 0.000
E06 Thyroiditis
0.682 0.318 0.000
M21.4 Flat foot [pes planus] (acquired)
0.681 0.319 0.000
N18.8 Other chronic renal failure
0.681 0.319 0.000
Q43.1 Hirschsprung's disease
0.680 0.320 0.000
E50-E64 Other nutritional deficiencies
0.680 0.320 0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis
0.679 0.320 0.000
H50.8 Other specified strabismus
0.679 0.321 0.000
M34.9 Systemic sclerosis, unspecified
0.678 0.322 0.000
Q43.8 Other specified congenital malformations of intestine
0.678 0.322 0.000
H50.9 Strabismus, unspecified
0.676 0.324 0.000
I20-I25 Ischaemic heart diseases
0.675 0.325 0.000
E88 Other metabolic disorders
0.675 0.325 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.674 0.326 0.000
M15.4 Erosive (osteo)arthrosis
0.674 0.326 0.000
Q43.7 Persistent cloaca
0.673 0.327 0.000
Q43.6 Congenital fistula of rectum and anus
0.673 0.327 0.000
Q43.5 Ectopic anus
0.673 0.327 0.000
Q43.4 Duplication of intestine
0.673 0.327 0.000
Q43.2 Other congenital functional disorders of colon
0.673 0.327 0.000
E05.8 Other thyrotoxicosis
0.672 0.328 0.000
H51 Other disorders of binocular movement
0.672 0.328 0.000
M15.8 Other polyarthrosis
0.672 0.328 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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