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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs9356551
log Bayes Factor = 24.3083
Chromosome 6   position 167,400,345  (GRCh37) Explore rs9356551 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.001 0.999
C44.3 Skin of other and unspecified parts of face
0.997 0.003 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E10-E14 Diabetes mellitus
0.000 0.004 0.996
E10 Insulin-dependent diabetes mellitus
0.000 0.006 0.994
E05.9 Thyrotoxicosis, unspecified
0.000 0.011 0.989
E50-E64 Other nutritional deficiencies
0.000 0.013 0.987
E53 Deficiency of other B group vitamins
0.000 0.017 0.983
E53.8 Deficiency of other specified B group vitamins
0.000 0.022 0.978
E14 Unspecified diabetes mellitus
0.000 0.024 0.976
C44 Other malignant neoplasms of skin
0.966 0.034 0.000
E10.9 Without complications
0.000 0.034 0.966
C44.5 Skin of trunk
0.961 0.039 0.000
E10.4 With neurological complications
0.000 0.041 0.959
E07 Other disorders of thyroid
0.000 0.043 0.957
E07.9 Disorder of thyroid, unspecified
0.000 0.067 0.933
E14.9 Without complications
0.000 0.071 0.929
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.082 0.918
C43-C44 Melanoma and other malignant neoplasms of skin
0.909 0.091 0.000
C43 Malignant melanoma of skin
0.898 0.102 0.000
C43.5 Malignant melanoma of trunk
0.889 0.111 0.000
E14.4 With neurological complications
0.000 0.123 0.877
E10.2 With renal complications
0.000 0.128 0.872
E03.8 Other specified hypothyroidism
0.000 0.149 0.851
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.153 0.847
E10.1 With ketoacidosis
0.000 0.172 0.828
E10.0 With coma
0.000 0.189 0.811
C43.9 Malignant melanoma of skin, unspecified
0.806 0.194 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.206 0.794
E53.9 Vitamin B deficiency, unspecified
0.000 0.230 0.770
C43.3 Malignant melanoma of other and unspecified parts of face
0.768 0.232 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.237 0.763
E61 Deficiency of other nutrient elements
0.000 0.245 0.755
E51 Thiamine deficiency
0.000 0.248 0.752
E14.3 With ophthalmic complications
0.000 0.257 0.743
C43.1 Malignant melanoma of eyelid, including canthus
0.741 0.258 0.000
C44.6 Skin of upper limb, including shoulder
0.737 0.263 0.000
E14.5 With peripheral circulatory complications
0.000 0.264 0.735
E14.2 Withrenal complications
0.000 0.273 0.727
E10.6 With other specified complications
0.000 0.275 0.725
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
C44.0 Skin of lip
0.715 0.285 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.286 0.714
E10.7 With multiple complications
0.000 0.287 0.712
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.292 0.708
E63 Other nutritional deficiencies
0.000 0.292 0.708
E50 Vitamin A deficiency
0.000 0.292 0.708
E60 Dietary zinc deficiency
0.000 0.292 0.708
E59 Dietary selenium deficiency
0.000 0.292 0.708
E58 Dietary calcium deficiency
0.000 0.292 0.708
E54 Ascorbic acid deficiency
0.000 0.292 0.708
E52 Niacin deficiency [pellagra]
0.000 0.292 0.708
E53.1 Pyridoxine deficiency
0.000 0.295 0.704
E53.0 Riboflavin deficiency
0.000 0.295 0.704
E14.7 With multiple complications
0.000 0.300 0.700
E14.0 With coma
0.000 0.300 0.700
E14.8 With unspecified complications
0.000 0.302 0.698
C44.9 Malignant neoplasm of skin, unspecified
0.695 0.305 0.000
C44.8 Overlapping lesion of skin
0.692 0.307 0.000
E07.1 Dyshormogenetic goitre
0.000 0.314 0.686
E07.0 Hypersecretion of calcitonin
0.000 0.314 0.686
E14.1 With ketoacidosis
0.000 0.321 0.679
E10.8 With unspecified complications
0.000 0.325 0.675
E56 Other vitamin deficiencies
0.000 0.327 0.673
E16 Other disorders of pancreatic internal secretion
0.000 0.351 0.649
E14.6 With other specified complications
0.000 0.356 0.644
C43.8 Overlapping malignant melanoma of skin
0.644 0.356 0.000
C43.0 Malignant melanoma of lip
0.644 0.356 0.000
E05.8 Other thyrotoxicosis
0.000 0.362 0.638
C43.4 Malignant melanoma of scalp and neck
0.609 0.391 0.000
E07.8 Other specified disorders of thyroid
0.000 0.394 0.606
E40-E46 Malnutrition
0.000 0.400 0.600
E61.2 Magnesium deficiency
0.000 0.414 0.586
E51.2 Wernicke's encephalopathy
0.000 0.417 0.583
E15 Nondiabetic hypoglycaemic coma
0.000 0.431 0.569
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.436 0.563
E16.2 Hypoglycaemia, unspecified
0.000 0.438 0.562
E13 Other specified diabetes mellitus
0.000 0.439 0.561
E65-E68 Obesity and other hyperalimentation
0.000 0.444 0.556
E10.3 With ophthalmic complications
0.000 0.447 0.553
C44.2 Skin of ear and external auricular canal
0.548 0.452 0.000
C43.6 Malignant melanoma of upper limb, including shoulder
0.545 0.455 0.000
E61.1 Iron deficiency
0.000 0.457 0.543
E61.9 Deficiency of nutrient element, unspecified
0.000 0.459 0.541
E61.8 Deficiency of other specified nutrient elements
0.000 0.459 0.541
E61.7 Deficiency of multiple nutrient elements
0.000 0.459 0.541
E61.6 Vanadium deficiency
0.000 0.459 0.541
E61.5 Molybdenum deficiency
0.000 0.459 0.541
E61.4 Chromium deficiency
0.000 0.459 0.541
E61.3 Manganese deficiency
0.000 0.459 0.541
E61.0 Copper deficiency
0.000 0.459 0.541
E51.9 Thiamine deficiency, unspecified
0.000 0.461 0.539
E51.8 Other manifestations of thiamine deficiency
0.000 0.461 0.539
E51.1 Beriberi
0.000 0.461 0.539
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.488 0.512
E12.8 With unspecified complications
0.000 0.488 0.512
E12.7 With multiple complications
0.000 0.488 0.512
E12.6 With other specified complications
0.000 0.488 0.512
E12.5 With peripheral circulatory complications
0.000 0.488 0.512
E12.4 With neurological complications
0.000 0.488 0.512
E12.3 With ophthalmic complications
0.000 0.488 0.512
E12.2 With renal complications
0.000 0.488 0.512
E12.1 With ketoacidosis
0.000 0.488 0.512
E12.0 With coma
0.000 0.488 0.512
E06 Thyroiditis
0.000 0.492 0.508
E50.9 Vitamin A deficiency, unspecified
0.000 0.492 0.507
E50.8 Other manifestations of vitamin A deficiency
0.000 0.492 0.507
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.492 0.507
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.492 0.507
E50.5 Vitamin A deficiency with night blindness
0.000 0.492 0.507
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.492 0.507
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.492 0.507
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.492 0.507
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.492 0.507
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.492 0.507
E63.9 Nutritional deficiency, unspecified
0.000 0.492 0.507
E63.8 Other specified nutritional deficiencies
0.000 0.492 0.507
E63.1 Imbalance of constituents of food intake
0.000 0.492 0.507
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.492 0.507
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.492 0.507
E64.8 Sequelae of other nutritional deficiencies
0.000 0.492 0.507
E64.3 Sequelae of rickets
0.000 0.492 0.507
E64.2 Sequelae of vitamin C deficiency
0.000 0.492 0.507
E64.1 Sequelae of vitamin A deficiency
0.000 0.492 0.507
E64.0 Sequelae of protein-energy malnutrition
0.000 0.492 0.507
E10.5 With peripheral circulatory complications
0.000 0.509 0.491
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.512 0.488
E56.9 Vitamin deficiency, unspecified
0.000 0.517 0.482
E56.8 Deficiency of other vitamins
0.000 0.517 0.482
E56.0 Deficiency of vitamin E
0.000 0.517 0.482
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.535 0.465
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.535 0.465
E16.4 Abnormal secretion of gastrin
0.000 0.535 0.465
E16.3 Increased secretion of glucagon
0.000 0.535 0.465
C43.2 Malignant melanoma of ear and external auricular canal
0.450 0.549 0.001
E55 Vitamin D deficiency
0.000 0.549 0.451
E56.1 Deficiency of vitamin K
0.000 0.553 0.447
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.570 0.430
E45 Retarded development following protein-energy malnutrition
0.000 0.570 0.430
E43 Unspecified severe protein-energy malnutrition
0.000 0.570 0.430
E42 Marasmic kwashiorkor
0.000 0.570 0.430
E41 Nutritional marasmus
0.000 0.570 0.430
E40 Kwashiorkor
0.000 0.570 0.430
E13.8 With unspecified complications
0.000 0.598 0.402
E13.7 With multiple complications
0.000 0.598 0.402
E13.6 With other specified complications
0.000 0.598 0.402
E13.5 With peripheral circulatory complications
0.000 0.598 0.402
E13.4 With neurological complications
0.000 0.598 0.402
E13.2 With renal complications
0.000 0.598 0.402
E13.1 With ketoacidosis
0.000 0.598 0.402
E13.0 With coma
0.000 0.598 0.402
E67 Other hyperalimentation
0.000 0.601 0.399
E68 Sequelae of hyperalimentation
0.000 0.601 0.399
E16.1 Other hypoglycaemia
0.000 0.604 0.396
E66 Obesity
0.000 0.609 0.391
E13.3 With ophthalmic complications
0.000 0.622 0.378
E06.5 Other chronic thyroiditis
0.000 0.635 0.364
E06.4 Drug-induced thyroiditis
0.000 0.635 0.364
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.635 0.364
E06.0 Acute thyroiditis
0.000 0.635 0.364
C44.1 Skin of eyelid, including canthus
0.361 0.639 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.645 0.355
E06.3 Autoimmune thyroiditis
0.000 0.658 0.342
E06.1 Subacute thyroiditis
0.000 0.676 0.323
E55.0 Rickets, active
0.000 0.676 0.323
E46 Unspecified protein-energy malnutrition
0.000 0.685 0.315
E20-E35 Disorders of other endocrine glands
0.000 0.686 0.314
E66.8 Other obesity
0.000 0.689 0.311
E44.1 Mild protein-energy malnutrition
0.000 0.691 0.308
E44.0 Moderate protein-energy malnutrition
0.000 0.691 0.308
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.705 0.295
E13.9 Without complications
0.000 0.709 0.291
E67.8 Other specified hyperalimentation
0.000 0.714 0.286
E67.3 Hypervitaminosis D
0.000 0.714 0.286
E67.2 Megavitamin-B6 syndrome
0.000 0.714 0.286
E67.1 Hypercarotenaemia
0.000 0.714 0.286
E67.0 Hypervitaminosis A
0.000 0.714 0.286
E66.1 Drug-induced obesity
0.000 0.720 0.280
E21.3 Hyperparathyroidism, unspecified
0.000 0.725 0.275
E04 Other non-toxic goitre
0.000 0.729 0.271
E06.9 Thyroiditis, unspecified
0.000 0.730 0.270
E65 Localised adiposity
0.000 0.744 0.256
C44.7 Skin of lower limb, including hip
0.254 0.746 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.749 0.251
L43.9 Lichen planus, unspecified
0.000 0.750 0.250
E66.0 Obesity due to excess calories
0.000 0.756 0.244
E26 Hyperaldosteronism
0.000 0.762 0.238
E25 Adrenogenital disorders
0.000 0.765 0.234
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.775 0.225
E32 Diseases of thymus
0.000 0.775 0.225
E31 Polyglandular dysfunction
0.000 0.775 0.225
E30 Disorders of puberty, not elsewhere classified
0.000 0.775 0.225
E28 Ovarian dysfunction
0.000 0.780 0.220
E21.4 Other specified disorders of parathyroid gland
0.000 0.788 0.212
E04.0 Non-toxic diffuse goitre
0.000 0.790 0.210
E21.2 Other hyperparathyroidism
0.000 0.792 0.208
E21.0 Primary hyperparathyroidism
0.000 0.796 0.204
E20 Hypoparathyroidism
0.000 0.799 0.201
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.799 0.201
E04.8 Other specified non-toxic goitre
0.000 0.806 0.194
E24 Cushing's syndrome
0.000 0.806 0.194
E28.3 Primary ovarian failure
0.000 0.808 0.192
E26.0 Primary hyperaldosteronism
0.000 0.816 0.184
E29 Testicular dysfunction
0.000 0.818 0.182
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.822 0.177
C43.7 Malignant melanoma of lower limb, including hip
0.172 0.828 0.000
E26.9 Hyperaldosteronism, unspecified
0.000 0.829 0.171
E26.8 Other hyperaldosteronism
0.000 0.829 0.171
E26.1 Secondary hyperaldosteronism
0.000 0.829 0.171
E22 Hyperfunction of pituitary gland
0.000 0.829 0.171
E23 Hypofunction and other disorders of pituitary gland
0.000 0.830 0.170
E25.9 Adrenogenital disorder, unspecified
0.000 0.832 0.168
E25.8 Other adrenogenital disorders
0.000 0.832 0.168
E30.9 Disorder of puberty, unspecified
0.000 0.838 0.162
E30.8 Other disorders of puberty
0.000 0.838 0.162
E30.1 Precocious puberty
0.000 0.838 0.162
E30.0 Delayed puberty
0.000 0.838 0.162
E31.9 Polyglandular dysfunction, unspecified
0.000 0.838 0.162
E31.8 Other polyglandular dysfunction
0.000 0.838 0.162
E31.1 Polyglandular hyperfunction
0.000 0.838 0.162
E31.0 Autoimmune polyglandular failure
0.000 0.838 0.162
E32.9 Disease of thymus, unspecified
0.000 0.838 0.162
E32.8 Other diseases of thymus
0.000 0.838 0.162
E32.1 Abscess of thymus
0.000 0.838 0.162
E32.0 Persistent hyperplasia of thymus
0.000 0.838 0.162
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.838 0.162
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.838 0.162
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.838 0.162
E28.9 Ovarian dysfunction, unspecified
0.000 0.842 0.158
E28.8 Other ovarian dysfunction
0.000 0.842 0.158
E28.1 Androgen excess
0.000 0.842 0.158
E28.0 Oestrogen excess
0.000 0.842 0.158
E20.8 Other hypoparathyroidism
0.000 0.855 0.144
E20.1 Pseudohypoparathyroidism
0.000 0.855 0.144
E20.0 Idiopathic hypoparathyroidism
0.000 0.855 0.144
E22.0 Acromegaly and pituitary gigantism
0.000 0.859 0.141
E24.8 Other Cushing's syndrome
0.000 0.860 0.139
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.860 0.139
E24.3 Ectopic ACTH syndrome
0.000 0.860 0.139
E24.1 Nelson's syndrome
0.000 0.860 0.139
L43 Lichen planus
0.000 0.863 0.137
E24.9 Cushing's syndrome, unspecified
0.000 0.864 0.136
E23.0 Hypopituitarism
0.000 0.866 0.134
E29.9 Testicular dysfunction, unspecified
0.000 0.869 0.131
E29.8 Other testicular dysfunction
0.000 0.869 0.131
E29.0 Testicular hyperfunction
0.000 0.869 0.131
E34 Other endocrine disorders
0.000 0.869 0.130
E24.0 Pituitary-dependent Cushing's disease
0.000 0.870 0.129
E04.2 Non-toxic multinodular goitre
0.000 0.872 0.128
E24.2 Drug-induced Cushing's syndrome
0.000 0.875 0.125
C44.4 Skin of scalp and neck
0.124 0.876 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.877 0.122
E22.8 Other hyperfunction of pituitary gland
0.000 0.877 0.122
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.878 0.122
E23.1 Drug-induced hypopituitarism
0.000 0.878 0.122
E20.9 Hypoparathyroidism, unspecified
0.000 0.879 0.120
E70-E90 Metabolic disorders
0.000 0.882 0.118
E04.1 Non-toxic single thyroid nodule
0.000 0.884 0.116
E83 Disorders of mineral metabolism
0.000 0.886 0.114
E23.2 Diabetes insipidus
0.000 0.886 0.114
E27 Other disorders of adrenal gland
0.000 0.887 0.113
L43.8 Other lichen planus
0.000 0.889 0.111
E83.3 Disorders of phosphorus metabolism
0.000 0.890 0.110
E23.7 Disorder of pituitary gland, unspecified
0.000 0.894 0.105
E83.5 Disorders of calcium metabolism
0.000 0.898 0.102
L43.3 Subacute (active) lichen planus
0.000 0.902 0.098
L43.2 Lichenoid drug reaction
0.000 0.902 0.098
L43.1 Bullous lichen planus
0.000 0.902 0.098
L43.0 Hypertrophic lichen planus
0.000 0.902 0.098
E04.9 Non-toxic goitre, unspecified
0.000 0.903 0.097
E83.1 Disorders of iron metabolism
0.000 0.905 0.095
E79 Disorders of purine and pyrimidine metabolism
0.000 0.905 0.095
E34.5 Androgen resistance syndrome
0.000 0.906 0.094
E34.4 Constitutional tall stature
0.000 0.906 0.094
E34.3 Short stature, not elsewhere classified
0.000 0.906 0.094
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.906 0.094
E34.1 Other hypersecretion of intestinal hormones
0.000 0.906 0.094
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.908 0.092
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.912 0.088
E29.1 Testicular hypofunction
0.000 0.912 0.087
E22.1 Hyperprolactinaemia
0.000 0.913 0.087
E84 Cystic fibrosis
0.000 0.915 0.085
E77 Disorders of glycoprotein metabolism
0.000 0.915 0.085
E76 Disorders of glycosaminoglycan metabolism
0.000 0.915 0.085
E72 Other disorders of amino-acid metabolism
0.000 0.915 0.085
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.915 0.085
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.915 0.085
G12.2 Motor neuron disease
0.000 0.916 0.084
E23.6 Other disorders of pituitary gland
0.000 0.917 0.083
E88 Other metabolic disorders
0.000 0.918 0.082
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.918 0.082
E83.8 Other disorders of mineral metabolism
0.000 0.918 0.082
E83.2 Disorders of zinc metabolism
0.000 0.918 0.082
E83.0 Disorders of copper metabolism
0.000 0.918 0.082
E74 Other disorders of carbohydrate metabolism
0.000 0.919 0.081
E27.5 Adrenomedullary hyperfunction
0.000 0.919 0.081
E27.0 Other adrenocortical overactivity
0.000 0.919 0.081
E27.9 Disorder of adrenal gland, unspecified
0.000 0.922 0.078
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.922 0.078
E34.9 Endocrine disorder, unspecified
0.000 0.922 0.078
E70 Disorders of aromatic amino-acid metabolism
0.000 0.922 0.078
E34.8 Other specified endocrine disorders
0.000 0.924 0.076
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.924 0.075
G12 Spinal muscular atrophy and related syndromes
0.000 0.926 0.074
E28.2 Polycystic ovarian syndrome
0.000 0.926 0.074
E27.1 Primary adrenocortical insufficiency
0.000 0.928 0.072
E73 Lactose intolerance
0.000 0.929 0.071
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.930 0.070
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.930 0.070
E34.0 Carcinoid syndrome
0.001 0.931 0.068
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.932 0.068
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.932 0.068
E79.1 Lesch-Nyhan syndrome
0.000 0.932 0.068
E88.2 Lipomatosis, not elsewhere classified
0.000 0.932 0.068
G11 Hereditary ataxia
0.000 0.932 0.068
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.000 0.932 0.068
E75.5 Other lipid storage disorders
0.000 0.933 0.067
E55.9 Vitamin D deficiency, unspecified
0.001 0.933 0.066
G11.9 Hereditary ataxia, unspecified
0.000 0.934 0.066
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.935 0.065
E85 Amyloidosis
0.000 0.935 0.065
E78.2 Mixed hyperlipidaemia
0.000 0.936 0.064
E75.6 Lipid storage disorder, unspecified
0.000 0.937 0.063
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.937 0.063
E75.3 Sphingolipidosis, unspecified
0.000 0.937 0.063
E75.1 Other gangliosidosis
0.000 0.937 0.063
E75.0 GM2 gangliosidosis
0.000 0.937 0.063
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.937 0.063
E75.2 Other sphingolipidosis
0.000 0.938 0.062
Z95.0 Presence of cardiac pacemaker
0.000 0.938 0.062
E71.3 Disorders of fatty-acid metabolism
0.000 0.939 0.061
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.939 0.061
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.939 0.061
E71.0 Maple-syrup-urine disease
0.000 0.939 0.061
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.939 0.061
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.939 0.061
E72.5 Disorders of glycine metabolism
0.000 0.939 0.061
E72.4 Disorders of ornithine metabolism
0.000 0.939 0.061
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.939 0.061
E72.2 Disorders of urea cycle metabolism
0.000 0.939 0.061
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.939 0.061
E72.0 Disorders of amino-acid transport
0.000 0.939 0.061
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.939 0.061
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.939 0.061
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.939 0.061
E76.2 Other mucopolysaccharidoses
0.000 0.939 0.061
E76.1 Mucopolysaccharidosis, type II
0.000 0.939 0.061
E76.0 Mucopolysaccharidosis, type I
0.000 0.939 0.061
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.939 0.061
E77.8 Other disorders of glycoprotein metabolism
0.000 0.939 0.061
E77.1 Defects in glycoprotein degradation
0.000 0.939 0.061
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.939 0.061
E84.9 Cystic fibrosis, unspecified
0.000 0.939 0.061
E84.8 Cystic fibrosis with other manifestations
0.000 0.939 0.061
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.939 0.061
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.939 0.061
E89.2 Postprocedural hypoparathyroidism
0.000 0.940 0.060
E88.8 Other specified metabolic disorders
0.000 0.941 0.059
G11.4 Hereditary spastic paraplegia
0.000 0.941 0.059
E88.9 Metabolic disorder, unspecified
0.000 0.941 0.059
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.941 0.058
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.941 0.058
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.941 0.058
E74.2 Disorders of galactose metabolism
0.000 0.941 0.058
E74.1 Disorders of fructose metabolism
0.000 0.941 0.058
E74.0 Glycogen storage disease
0.000 0.941 0.058
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.944 0.056
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.944 0.056
E70.2 Disorders of tyrosine metabolism
0.000 0.944 0.056
E70.1 Other hyperphenylalaninaemias
0.000 0.944 0.056
E70.0 Classical phenylketonuria
0.000 0.944 0.056
E78.4 Other hyperlipidaemia
0.000 0.945 0.055
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.945 0.055
E27.2 Addisonian crisis
0.000 0.945 0.054
G12.9 Spinal muscular atrophy, unspecified
0.000 0.946 0.053
G12.8 Other spinal muscular atrophies and related syndromes
0.000 0.946 0.053
G12.1 Other inherited spinal muscular atrophy
0.000 0.946 0.053
G12.0 Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
0.000 0.946 0.053
E88.3 Tumour lysis syndrome
0.000 0.948 0.052
G10 Huntington's disease
0.000 0.948 0.051
E73.8 Other lactose intolerance
0.000 0.949 0.051
E73.1 Secondary lactase deficiency
0.000 0.949 0.051
E73.0 Congenital lactase deficiency
0.000 0.949 0.051
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.950 0.050
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.950 0.050
E89.5 Postprocedural testicular hypofunction
0.000 0.950 0.050
E89.1 Postprocedural hypoinsulinaemia
0.000 0.950 0.050
E78.8 Other disorders of lipoprotein metabolism
0.000 0.950 0.050
G14 Postpolio syndrome
0.000 0.950 0.050
E70.3 Albinism
0.000 0.951 0.049
G11.8 Other hereditary ataxias
0.000 0.951 0.049
G11.3 Cerebellar ataxia with defective DNA repair
0.000 0.951 0.049
G11.2 Late-onset cerebellar ataxia
0.000 0.951 0.049
G11.1 Early-onset cerebellar ataxia
0.000 0.951 0.049
G11.0 Congenital nonprogressive ataxia
0.000 0.951 0.049
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.000 0.951 0.049
E27.8 Other specified disorders of adrenal gland
0.000 0.952 0.047
E78.1 Pure hyperglyceridaemia
0.000 0.953 0.047
E78.3 Hyperchylomicronaemia
0.000 0.953 0.047
E85.8 Other amyloidosis
0.000 0.953 0.047
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.953 0.047
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.953 0.047
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.953 0.047
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.954 0.046
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.956 0.044
E78.6 Lipoprotein deficiency
0.000 0.956 0.044
E85.4 Organ-limited amyloidosis
0.000 0.956 0.044
E89.0 Postprocedural hypothyroidism
0.000 0.957 0.043
E85.9 Amyloidosis, unspecified
0.000 0.958 0.042
E89.4 Postprocedural ovarian failure
0.000 0.959 0.041
E89.3 Postprocedural hypopituitarism
0.000 0.959 0.041
E85.3 Secondary systemic amyloidosis
0.000 0.962 0.038
E73.9 Lactose intolerance, unspecified
0.000 0.963 0.037
G13.8 Systemic atrophy primarily affecting central nervous system in other diseases classified elsewhere
0.000 0.965 0.035
G13.2 Systemic atrophy primarily affecting central nervous system in myxoedema
0.000 0.965 0.035
G13.1 Other systemic atrophy primarily affecting central nervous system in neoplastic disease
0.000 0.965 0.035
G13.0 Paraneoplastic neuromyopathy and neuropathy
0.000 0.965 0.035
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.966 0.034
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.975 0.024
E80.5 Crigler-Najjar syndrome
0.000 0.975 0.024
E80.3 Defects of catalase and peroxydase
0.000 0.975 0.024
E80.0 Hereditary erythropoietic porphyria
0.000 0.975 0.024
E83.4 Disorders of magnesium metabolism
0.000 0.978 0.022
E80.2 Other porphyria
0.000 0.978 0.022
E80.1 Porphyria cutanea tarda
0.000 0.979 0.021
E80.6 Other disorders of bilirubin metabolism
0.000 0.980 0.019
K50.9 Crohn's disease, unspecified
0.000 0.981 0.019
E86 Volume depletion
0.000 0.981 0.019
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.985 0.015
E78.5 Hyperlipidaemia, unspecified
0.000 0.986 0.014
K50 Crohn's disease [regional enteritis]
0.000 0.986 0.014
L40-L45 Papulosquamous disorders
0.000 0.986 0.014
K50.8 Other Crohn's disease
0.000 0.987 0.013
Z45.0 Adjustment and management of cardiac pacemaker
0.000 0.988 0.012
K50.0 Crohn's disease of small intestine
0.000 0.988 0.012
E80.4 Gilbert's syndrome
0.000 0.989 0.011
L41 Parapsoriasis
0.000 0.990 0.010
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.990 0.010
E11 Non-insulin-dependent diabetes mellitus
0.000 0.990 0.010
L44 Other papulosquamous disorders
0.000 0.991 0.009
E11.0 With coma
0.000 0.991 0.009
K52.1 Toxic gastro-enteritis and colitis
0.000 0.992 0.008
R16.1 Splenomegaly, not elsewhere classified
0.000 0.992 0.008
L42 Pityriasis rosea
0.000 0.992 0.007
L41.9 Parapsoriasis, unspecified
0.000 0.992 0.007
L41.8 Other parapsoriasis
0.000 0.992 0.007
L41.5 Retiform parapsoriasis
0.000 0.992 0.007
L41.4 Large plaque parapsoriasis
0.000 0.992 0.007
L41.3 Small plaque parapsoriasis
0.000 0.992 0.007
L41.2 Lymphomatoid papulosis
0.000 0.992 0.007
L41.1 Pityriasis lichenoides chronica
0.000 0.992 0.007
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.992 0.007
E66.9 Obesity, unspecified
0.000 0.993 0.007
E11.7 With multiple complications
0.000 0.993 0.007
L03.0 Cellulitis of finger and toe
0.000 0.993 0.007
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.993 0.007
L44.9 Papulosquamous disorder, unspecified
0.000 0.993 0.007
L44.8 Other specified papulosquamous disorders
0.000 0.993 0.007
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.993 0.007
L44.3 Lichen ruber moniliformis
0.000 0.993 0.007
L44.2 Lichen striatus
0.000 0.993 0.007
L44.1 Lichen nitidus
0.000 0.993 0.007
E11.8 With unspecified complications
0.000 0.993 0.007
K50-K52 Noninfective enteritis and colitis
0.000 0.993 0.007
D23.3 Skin of other and unspecified parts of face
0.000 0.993 0.007
K50.1 Crohn's disease of large intestine
0.000 0.993 0.006
E87.0 Hyperosmolality and hypernatraemia
0.000 0.994 0.006
K52 Other non-infective gastro-enteritis and colitis
0.000 0.994 0.006
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances
0.000 0.994 0.006
E11.2 With renal complications
0.000 0.994 0.006
L44.0 Pityriasis rubra pilaris
0.000 0.994 0.005
K52.0 Gastro-enteritis and colitis due to radiation
0.000 0.994 0.006
R16.2 Hepatomegaly with splenomegaly, not elsewhere classified
0.000 0.994 0.006
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.000 0.995 0.005
E11.6 With other specified complications
0.000 0.995 0.005
C32.1 Supraglottis
0.005 0.995 0.000
E87.4 Mixed disorder of acid-base balance
0.000 0.995 0.005
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.995 0.005
E87.3 Alkalosis
0.000 0.995 0.005

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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