TreeWAS – Variant ID: rs9380215

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M45.X9 Ankylosing spondylitis (Site unspecified)	1.000	0.000	0.000
M45 Ankylosing spondylitis	0.975	0.025	0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.949	0.051	0.000
K90.0 Coeliac disease	0.000	0.086	0.914
M45.X2 Ankylosing spondylitis (Cervical region)	0.797	0.203	0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.699	0.301	0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.699	0.301	0.000
M45.X6 Ankylosing spondylitis (Lumbar region)	0.699	0.301	0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.699	0.301	0.000
M45.X4 Ankylosing spondylitis (Thoracic region)	0.699	0.301	0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.699	0.301	0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.699	0.301	0.000
E10 Insulin-dependent diabetes mellitus	0.000	0.306	0.694
M45-M49 Spondylopathies	0.688	0.312	0.000
E10.9 Without complications	0.000	0.318	0.682
E10.3 With ophthalmic complications	0.000	0.322	0.678
E10.1 With ketoacidosis	0.000	0.325	0.675
E03.9 Hypothyroidism, unspecified	0.000	0.406	0.594
M06 Other rheumatoid arthritis	0.580	0.420	0.000
E10.5 With peripheral circulatory complications	0.000	0.423	0.577
M06.9 Rheumatoid arthritis, unspecified	0.575	0.425	0.000
M05-M14 Inflammatory polyarthropathies	0.565	0.435	0.000
M06.0 Seronegative rheumatoid arthritis	0.560	0.440	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.557	0.443	0.000
E03 Other hypothyroidism	0.000	0.448	0.552
E10-E14 Diabetes mellitus	0.000	0.451	0.549
M48 Other spondylopathies	0.545	0.455	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.540	0.460	0.000
E00-E07 Disorders of thyroid gland	0.000	0.463	0.537
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.534	0.466	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.474	0.526
E10.4 With neurological complications	0.000	0.475	0.525
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.524	0.476	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.498	0.502	0.000
E10.8 With unspecified complications	0.000	0.502	0.498
E10.7 With multiple complications	0.000	0.502	0.498
E10.6 With other specified complications	0.000	0.502	0.498
E10.2 With renal complications	0.000	0.502	0.498
E10.0 With coma	0.000	0.502	0.498
M49 Spondylopathies in diseases classified elsewhere	0.494	0.506	0.000
M46 Other inflammatory spondylopathies	0.478	0.521	0.000
M86-M90 Other osteopathies	0.478	0.522	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.524	0.476
M10 Gout	0.471	0.529	0.000
M00-M03 Infectious arthropathies	0.468	0.532	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.539	0.461
M60-M63 Disorders of muscles	0.456	0.544	0.000
M06.3 Rheumatoid nodule	0.451	0.549	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.448	0.552	0.000
M06.4 Inflammatory polyarthropathy	0.444	0.556	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.444	0.556	0.000
M07 Psoriatic and enteropathic arthropathies	0.443	0.557	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.442	0.558	0.000
M48.0 Spinal stenosis	0.439	0.561	0.000
M91-M94 Chondropathies	0.439	0.561	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.438	0.562	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.564	0.436
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.431	0.569	0.000
M40-M43 Deforming dorsopathies	0.428	0.572	0.000
M48.02 Spinal stenosis (Cervical region)	0.421	0.579	0.000
M06.8 Other specified rheumatoid arthritis	0.416	0.584	0.000
M06.2 Rheumatoid bursitis	0.416	0.584	0.000
M06.1 Adult-onset Still's disease	0.416	0.584	0.000
E16 Other disorders of pancreatic internal secretion	0.000	0.585	0.415
E06 Thyroiditis	0.000	0.588	0.412
E13 Other specified diabetes mellitus	0.000	0.592	0.408
M12 Other specific arthropathies	0.405	0.594	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.405	0.594	0.000
M08 Juvenile arthritis	0.405	0.594	0.000
M10.9 Gout, unspecified	0.404	0.596	0.000
M89 Other disorders of bone	0.403	0.597	0.000
M06.08 Seronegative rheumatoid arthritis (Other)	0.401	0.599	0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.401	0.599	0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.401	0.599	0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.401	0.599	0.000
M06.04 Seronegative rheumatoid arthritis (Hand)	0.401	0.599	0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.401	0.599	0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.401	0.599	0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.401	0.599	0.000
M11 Other crystal arthropathies	0.399	0.601	0.000
E40-E46 Malnutrition	0.000	0.602	0.398
M48.5 Collapsed vertebra, not elsewhere classified	0.396	0.603	0.000
E03.5 Myxoedema coma	0.000	0.604	0.396
E03.4 Atrophy of thyroid (acquired)	0.000	0.604	0.396
E03.3 Postinfectious hypothyroidism	0.000	0.604	0.396
E03.1 Congenital hypothyroidism without goitre	0.000	0.604	0.396
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.604	0.396
M02 Reactive arthropathies	0.394	0.606	0.000
E12 Malnutrition-related diabetes mellitus	0.000	0.606	0.394
M48.9 Spondylopathy, unspecified	0.391	0.609	0.000
M48.8 Other specified spondylopathies	0.391	0.609	0.000
M48.4 Fatigue fracture of vertebra	0.391	0.609	0.000
M48.3 Traumatic spondylopathy	0.391	0.609	0.000
M48.2 Kissing spine	0.391	0.609	0.000
M48.1 Ankylosing hyperostosis [Forestier]	0.391	0.609	0.000
K90 Intestinal malabsorption	0.000	0.610	0.390
E16.2 Hypoglycaemia, unspecified	0.000	0.611	0.389
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.615	0.385
E00 Congenital iodine-deficiency syndrome	0.000	0.615	0.385
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.615	0.385
M05 Seropositive rheumatoid arthritis	0.383	0.616	0.000
M62 Other disorders of muscle	0.383	0.617	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.381	0.619	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.376	0.624	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.374	0.626	0.000
M10.99 Gout, unspecified (Site unspecified)	0.373	0.627	0.000
M88 Paget's disease of bone [osteitis deformans]	0.371	0.629	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.370	0.630	0.000
M14 Arthropathies in other diseases classified elsewhere	0.370	0.630	0.000
E20-E35 Disorders of other endocrine glands	0.000	0.632	0.368
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.364	0.636	0.000
M86 Osteomyelitis	0.364	0.636	0.000
M46.4 Discitis, unspecified	0.360	0.640	0.000
M06.34 Rheumatoid nodule (Hand)	0.358	0.642	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.642	0.358
M65-M68 Disorders of synovium and tendon	0.357	0.643	0.000
M00 Pyogenic arthritis	0.355	0.645	0.000
M07.3 Other psoriatic arthropathies	0.355	0.645	0.000
M49.8 Spondylopathy in other diseases classified elsewhere	0.354	0.646	0.000
M49.5 Collapsed vertebra in diseases classified elsewhere	0.354	0.646	0.000
M49.4 Neuropathic spondylopathy	0.354	0.646	0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere	0.354	0.646	0.000
M49.2 Enterobacterial spondylitis	0.354	0.646	0.000
M49.1 Brucella spondylitis	0.354	0.646	0.000
M49.0 Tuberculosis of spine	0.354	0.646	0.000
M40 Kyphosis and lordosis	0.352	0.648	0.000
M93 Other osteochondropathies	0.348	0.652	0.000
M46.8 Other specified inflammatory spondylopathies	0.343	0.657	0.000
M46.5 Other infective spondylopathies	0.343	0.657	0.000
M46.3 Infection of intervertebral disk (pyogenic)	0.343	0.657	0.000
M46.2 Osteomyelitis of vertebra	0.343	0.657	0.000
M46.1 Sacro-iliitis, not elsewhere classified	0.343	0.657	0.000
M46.0 Spinal enthesopathy	0.343	0.657	0.000
E05.8 Other thyrotoxicosis	0.000	0.658	0.342
E05.5 Thyroid crisis or storm	0.000	0.658	0.342
E05.4 Thyrotoxicosis factitia	0.000	0.658	0.342
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.658	0.342
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.658	0.342
M48.04 Spinal stenosis (Thoracic region)	0.341	0.659	0.000
M02.3 Reiter's disease	0.340	0.659	0.000
E03.8 Other specified hypothyroidism	0.000	0.660	0.340
M10.4 Other secondary gout	0.338	0.662	0.000
M10.3 Gout due to impairment of renal function	0.338	0.662	0.000
M10.2 Drug-induced gout	0.338	0.662	0.000
M10.1 Lead-induced gout	0.338	0.662	0.000
M10.0 Idiopathic gout	0.338	0.662	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.664	0.336
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.336	0.664	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.336	0.664	0.000
M90 Osteopathies in diseases classified elsewhere	0.334	0.665	0.000
M87 Osteonecrosis	0.332	0.668	0.000
M62.8 Other specified disorders of muscle	0.331	0.669	0.000
E15 Nondiabetic hypoglycaemic coma	0.000	0.669	0.331
M63 Disorders of muscle in diseases classified elsewhere	0.327	0.673	0.000
M61 Calcification and ossification of muscle	0.327	0.673	0.000
M60 Myositis	0.327	0.673	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.323	0.677	0.000
M06.38 Rheumatoid nodule (Other)	0.323	0.677	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.323	0.677	0.000
M06.36 Rheumatoid nodule (Lower leg)	0.323	0.677	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.323	0.677	0.000
M06.33 Rheumatoid nodule (Forearm)	0.323	0.677	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.323	0.677	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.323	0.677	0.000
M06.30 Rheumatoid nodule (Multiple sites)	0.323	0.677	0.000
E06.3 Autoimmune thyroiditis	0.000	0.678	0.322
M94 Other disorders of cartilage	0.322	0.678	0.000
M80-M85 Disorders of bone density and structure	0.321	0.679	0.000
M89.9 Disorder of bone, unspecified	0.321	0.679	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.318	0.681	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.318	0.681	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.318	0.681	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.318	0.681	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.318	0.681	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.318	0.681	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.318	0.681	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.318	0.681	0.000
M07.6 Other enteropathic arthropathies	0.317	0.682	0.000
M07.5 Arthropathy in ulcerative colitis	0.317	0.682	0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.317	0.682	0.000
M07.2 Psoriatic spondylitis	0.317	0.682	0.000
M07.1 Arthritis mutilans	0.317	0.682	0.000
M07.0 Distal interphalangeal psoriatic arthropathy	0.317	0.682	0.000
E27 Other disorders of adrenal gland	0.000	0.683	0.317
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)	0.315	0.685	0.000
M48.05 Spinal stenosis (Thoracolumbar region)	0.315	0.685	0.000
M48.03 Spinal stenosis (Cervicothoracic region)	0.315	0.685	0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)	0.315	0.685	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.685	0.315
M92 Other juvenile osteochondrosis	0.314	0.685	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.314	0.685	0.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.686	0.314
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.313	0.687	0.000
M89.3 Hypertrophy of bone	0.312	0.688	0.000
M89.8 Other specified disorders of bone	0.308	0.692	0.000
M48.00 Spinal stenosis (Multiple sites in spine)	0.308	0.692	0.000
E13.9 Without complications	0.000	0.693	0.307
M42 Spinal osteochondrosis	0.307	0.693	0.000
M46.9 Inflammatory spondylopathy, unspecified	0.307	0.693	0.000
E46 Unspecified protein-energy malnutrition	0.000	0.694	0.306
M48.07 Spinal stenosis (Lumbosacral region)	0.304	0.696	0.000
M43 Other deforming dorsopathies	0.303	0.696	0.000
M02.39 Reiter's disease (Site unspecified)	0.302	0.698	0.000
M47 Spondylosis	0.302	0.698	0.000
M86.8 Other osteomyelitis	0.301	0.699	0.000
E14 Unspecified diabetes mellitus	0.000	0.700	0.300
M06.19 Adult-onset Still's disease (Site unspecified)	0.298	0.701	0.000
M06.18 Adult-onset Still's disease (Other)	0.298	0.701	0.000
M06.17 Adult-onset Still's disease (Ankle and foot)	0.298	0.701	0.000
M06.16 Adult-onset Still's disease (Lower leg)	0.298	0.701	0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.298	0.701	0.000
M06.14 Adult-onset Still's disease (Hand)	0.298	0.701	0.000
M06.13 Adult-onset Still's disease (Forearm)	0.298	0.701	0.000
M06.12 Adult-onset Still's disease (Upper arm)	0.298	0.701	0.000
M06.11 Adult-onset Still's disease (Shoulder region)	0.298	0.701	0.000
M06.10 Adult-onset Still's disease (Multiple sites)	0.298	0.701	0.000
M06.29 Rheumatoid bursitis (Site unspecified)	0.298	0.701	0.000
M06.28 Rheumatoid bursitis (Other)	0.298	0.701	0.000
M06.27 Rheumatoid bursitis (Ankle and foot)	0.298	0.701	0.000
M06.26 Rheumatoid bursitis (Lower leg)	0.298	0.701	0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.298	0.701	0.000
M06.24 Rheumatoid bursitis (Hand)	0.298	0.701	0.000
M06.23 Rheumatoid bursitis (Forearm)	0.298	0.701	0.000
M06.22 Rheumatoid bursitis (Upper arm)	0.298	0.701	0.000
M06.21 Rheumatoid bursitis (Shoulder region)	0.298	0.701	0.000
M06.20 Rheumatoid bursitis (Multiple sites)	0.298	0.701	0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.298	0.701	0.000
M06.88 Other specified rheumatoid arthritis (Other)	0.298	0.701	0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.298	0.701	0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.298	0.701	0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.298	0.701	0.000
M06.84 Other specified rheumatoid arthritis (Hand)	0.298	0.701	0.000
M06.83 Other specified rheumatoid arthritis (Forearm)	0.298	0.701	0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.298	0.701	0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.298	0.701	0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.298	0.701	0.000
E07 Other disorders of thyroid	0.000	0.701	0.298
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.702	0.298
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.702	0.298
E16.4 Abnormal secretion of gastrin	0.000	0.702	0.298
E16.3 Increased secretion of glucagon	0.000	0.702	0.298
E16.1 Other hypoglycaemia	0.000	0.702	0.298
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)	0.296	0.704	0.000
E06.9 Thyroiditis, unspecified	0.000	0.704	0.295
E06.5 Other chronic thyroiditis	0.000	0.704	0.295
E06.4 Drug-induced thyroiditis	0.000	0.704	0.295
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.704	0.295
E06.1 Subacute thyroiditis	0.000	0.704	0.295
E06.0 Acute thyroiditis	0.000	0.704	0.295
M88.9 Paget's disease of bone, unspecified	0.295	0.705	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.295	0.705	0.000
E13.8 With unspecified complications	0.000	0.707	0.292
E13.7 With multiple complications	0.000	0.707	0.292
E13.6 With other specified complications	0.000	0.707	0.292
E13.5 With peripheral circulatory complications	0.000	0.707	0.292
E13.4 With neurological complications	0.000	0.707	0.292
E13.3 With ophthalmic complications	0.000	0.707	0.292
E13.2 With renal complications	0.000	0.707	0.292
E13.1 With ketoacidosis	0.000	0.707	0.292
E13.0 With coma	0.000	0.707	0.292
E21.0 Primary hyperparathyroidism	0.000	0.708	0.292
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.291	0.709	0.000
M08.9 Juvenile arthritis, unspecified	0.291	0.709	0.000
M08.8 Other juvenile arthritis	0.291	0.709	0.000
M08.4 Pauciarticular juvenile arthritis	0.291	0.709	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.291	0.709	0.000
M08.2 Juvenile arthritis with systemic onset	0.291	0.709	0.000
M08.1 Juvenile ankylosing spondylitis	0.291	0.709	0.000
M08.0 Juvenile rheumatoid arthritis	0.291	0.709	0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.291	0.709	0.000
M09.2 Juvenile arthritis in ulcerative colitis	0.291	0.709	0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.291	0.709	0.000
M09.0 Juvenile arthritis in psoriasis	0.291	0.709	0.000
M12.8 Other specific arthropathies, not elsewhere classified	0.291	0.709	0.000
M12.5 Traumatic arthropathy	0.291	0.709	0.000
M12.4 Intermittent hydrarthrosis	0.291	0.709	0.000
M12.3 Palindromic rheumatism	0.291	0.709	0.000
M12.2 Villonodular synovitis (pigmented)	0.291	0.709	0.000
M12.1 Kaschin-Beck disease	0.291	0.709	0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.291	0.709	0.000
M10.98 Gout, unspecified (Other)	0.290	0.710	0.000
M10.95 Gout, unspecified (Pelvic region and thigh)	0.290	0.710	0.000
M10.93 Gout, unspecified (Forearm)	0.290	0.710	0.000
M10.92 Gout, unspecified (Upper arm)	0.290	0.710	0.000
M10.91 Gout, unspecified (Shoulder region)	0.290	0.710	0.000
M10.90 Gout, unspecified (Multiple sites)	0.290	0.710	0.000
M89.6 Osteopathy after poliomyelitis	0.289	0.711	0.000
M89.5 Osteolysis	0.289	0.711	0.000
M89.4 Other hypertrophic osteo-arthropathy	0.289	0.711	0.000
M89.2 Other disorders of bone development and growth	0.289	0.711	0.000
M89.1 Epiphyseal arrest	0.289	0.711	0.000
M89.0 Algoneurodystrophy	0.289	0.711	0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.713	0.287
M11.9 Crystal arthropathy, unspecified	0.286	0.714	0.000
M11.8 Other specified crystal arthropathies	0.286	0.714	0.000
M11.1 Familial chondrocalcinosis	0.286	0.714	0.000
M11.0 Hydroxyapatite deposition disease	0.286	0.714	0.000
M07.36 Other psoriatic arthropathies (Lower leg)	0.286	0.714	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.715	0.285
E45 Retarded development following protein-energy malnutrition	0.000	0.715	0.285
E43 Unspecified severe protein-energy malnutrition	0.000	0.715	0.285
E42 Marasmic kwashiorkor	0.000	0.715	0.285
E41 Nutritional marasmus	0.000	0.715	0.285
E40 Kwashiorkor	0.000	0.715	0.285
E27.1 Primary adrenocortical insufficiency	0.000	0.715	0.285
M48.59 Collapsed vertebra, not elsewhere classified (Site unspecified)	0.284	0.715	0.000
M48.58 Collapsed vertebra, not elsewhere classified (Sacral and sacrococcygeal region)	0.284	0.715	0.000
M48.57 Collapsed vertebra, not elsewhere classified (Lumbosacral region)	0.284	0.715	0.000
M48.55 Collapsed vertebra, not elsewhere classified (Thoracolumbar region)	0.284	0.715	0.000
M48.53 Collapsed vertebra, not elsewhere classified (Cervicothoracic region)	0.284	0.715	0.000
M48.52 Collapsed vertebra, not elsewhere classified (Cervical region)	0.284	0.715	0.000
M48.51 Collapsed vertebra, not elsewhere classified (Occipito-atlanto-axial region)	0.284	0.715	0.000
M48.50 Collapsed vertebra, not elsewhere classified (Multiple sites in spine)	0.284	0.715	0.000
M41 Scoliosis	0.284	0.716	0.000
M93.9 Osteochondropathy, unspecified	0.283	0.716	0.000
M02.9 Reactive arthopathy, unspecified	0.282	0.717	0.000
M02.8 Other reactive arthropathies	0.282	0.717	0.000
M02.2 Postimmunisation arthropathy	0.282	0.717	0.000
M02.1 Postdysenteric arthropathy	0.282	0.717	0.000
M02.0 Arthropathy following intestinal bypass	0.282	0.717	0.000
E12.9 Without complications	0.000	0.718	0.282
E12.8 With unspecified complications	0.000	0.718	0.282
E12.7 With multiple complications	0.000	0.718	0.282
E12.6 With other specified complications	0.000	0.718	0.282
E12.5 With peripheral circulatory complications	0.000	0.718	0.282
E12.4 With neurological complications	0.000	0.718	0.282
E12.3 With ophthalmic complications	0.000	0.718	0.282
E12.2 With renal complications	0.000	0.718	0.282
E12.1 With ketoacidosis	0.000	0.718	0.282
E12.0 With coma	0.000	0.718	0.282
M40.2 Other and unspecified kyphosis	0.282	0.718	0.000
E22 Hyperfunction of pituitary gland	0.000	0.719	0.281
M10.94 Gout, unspecified (Hand)	0.281	0.719	0.000
M48.19 Ankylosing hyperostosis [Forestier] (Site unspecified)	0.280	0.719	0.000
M48.18 Ankylosing hyperostosis [Forestier] (Sacral and sacrococcygeal region)	0.280	0.719	0.000
M48.17 Ankylosing hyperostosis [Forestier] (Lumbosacral region)	0.280	0.719	0.000
M48.16 Ankylosing hyperostosis [Forestier] (Lumbar region)	0.280	0.719	0.000
M48.15 Ankylosing hyperostosis [Forestier] (Thoracolumbar region)	0.280	0.719	0.000
M48.14 Ankylosing hyperostosis [Forestier] (Thoracic region)	0.280	0.719	0.000
M48.13 Ankylosing hyperostosis [Forestier] (Cervicothoracic region)	0.280	0.719	0.000
M48.12 Ankylosing hyperostosis [Forestier] (Cervical region)	0.280	0.719	0.000
M48.11 Ankylosing hyperostosis [Forestier] (Occipito-atlanto-axial region)	0.280	0.719	0.000
M48.10 Ankylosing hyperostosis [Forestier] (Multiple sites in spine)	0.280	0.719	0.000
M48.29 Kissing spine (Site unspecified)	0.280	0.719	0.000
M48.28 Kissing spine (Sacral and sacrococcygeal region)	0.280	0.719	0.000
M48.27 Kissing spine (Lumbosacral region)	0.280	0.719	0.000
M48.26 Kissing spine (Lumbar region)	0.280	0.719	0.000
M48.25 Kissing spine (Thoracolumbar region)	0.280	0.719	0.000
M48.24 Kissing spine (Thoracic region)	0.280	0.719	0.000
M48.23 Kissing spine (Cervicothoracic region)	0.280	0.719	0.000
M48.22 Kissing spine (Cervical region)	0.280	0.719	0.000
M48.21 Kissing spine (Occipito-atlanto-axial region)	0.280	0.719	0.000
M48.20 Kissing spine (Multiple sites in spine)	0.280	0.719	0.000
M48.39 Traumatic spondylopathy (Site unspecified)	0.280	0.719	0.000
M48.38 Traumatic spondylopathy (Sacral and sacrococcygeal region)	0.280	0.719	0.000
M48.37 Traumatic spondylopathy (Lumbosacral region)	0.280	0.719	0.000
M48.36 Traumatic spondylopathy (Lumbar region)	0.280	0.719	0.000
M48.35 Traumatic spondylopathy (Thoracolumbar region)	0.280	0.719	0.000
M48.34 Traumatic spondylopathy (Thoracic region)	0.280	0.719	0.000
M48.33 Traumatic spondylopathy (Cervicothoracic region)	0.280	0.719	0.000
M48.32 Traumatic spondylopathy (Cervical region)	0.280	0.719	0.000
M48.31 Traumatic spondylopathy (Occipito-atlanto-axial region)	0.280	0.719	0.000
M48.30 Traumatic spondylopathy (Multiple sites in spine)	0.280	0.719	0.000
M48.49 Fatigue fracture of vertebra (Site unspecified)	0.280	0.719	0.000
M48.48 Fatigue fracture of vertebra (Sacral and sacrococcygeal region)	0.280	0.719	0.000
M48.47 Fatigue fracture of vertebra (Lumbosacral region)	0.280	0.719	0.000
M48.46 Fatigue fracture of vertebra (Lumbar region)	0.280	0.719	0.000
M48.45 Fatigue fracture of vertebra (Thoracolumbar region)	0.280	0.719	0.000
M48.44 Fatigue fracture of vertebra (Thoracic region)	0.280	0.719	0.000
M48.43 Fatigue fracture of vertebra (Cervicothoracic region)	0.280	0.719	0.000
M48.42 Fatigue fracture of vertebra (Cervical region)	0.280	0.719	0.000
M48.41 Fatigue fracture of vertebra (Occipito-atlanto-axial region)	0.280	0.719	0.000
M48.40 Fatigue fracture of vertebra (Multiple sites in spine)	0.280	0.719	0.000
M48.89 Other specified spondylopathies (Site unspecified)	0.280	0.719	0.000
M48.88 Other specified spondylopathies (Sacral and sacrococcygeal region)	0.280	0.719	0.000
M48.87 Other specified spondylopathies (Lumbosacral region)	0.280	0.719	0.000
M48.86 Other specified spondylopathies (Lumbar region)	0.280	0.719	0.000
M48.85 Other specified spondylopathies (Thoracolumbar region)	0.280	0.719	0.000
M48.84 Other specified spondylopathies (Thoracic region)	0.280	0.719	0.000
M48.83 Other specified spondylopathies (Cervicothoracic region)	0.280	0.719	0.000
M48.82 Other specified spondylopathies (Cervical region)	0.280	0.719	0.000
M48.81 Other specified spondylopathies (Occipito-atlanto-axial region)	0.280	0.719	0.000
M48.80 Other specified spondylopathies (Multiple sites in spine)	0.280	0.719	0.000
M48.99 Spondylopathy, unspecified (Site unspecified)	0.280	0.719	0.000
M48.98 Spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.280	0.719	0.000
M48.97 Spondylopathy, unspecified (Lumbosacral region)	0.280	0.719	0.000
M48.96 Spondylopathy, unspecified (Lumbar region)	0.280	0.719	0.000
M48.95 Spondylopathy, unspecified (Thoracolumbar region)	0.280	0.719	0.000
M48.94 Spondylopathy, unspecified (Thoracic region)	0.280	0.719	0.000
M48.93 Spondylopathy, unspecified (Cervicothoracic region)	0.280	0.719	0.000
M48.92 Spondylopathy, unspecified (Cervical region)	0.280	0.719	0.000
M48.91 Spondylopathy, unspecified (Occipito-atlanto-axial region)	0.280	0.719	0.000
M48.90 Spondylopathy, unspecified (Multiple sites in spine)	0.280	0.719	0.000
M89.96 Disorder of bone, unspecified (Lower leg)	0.280	0.720	0.000
K90.8 Other intestinal malabsorption	0.000	0.720	0.280
K90.3 Pancreatic steatorrhoea	0.000	0.720	0.280
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.720	0.280
K90.1 Tropical sprue	0.000	0.720	0.280
M11.2 Other chondrocalcinosis	0.280	0.720	0.000
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.277	0.723	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.724	0.276
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.724	0.276
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.724	0.276
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.724	0.276
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.724	0.276
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.724	0.276
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.724	0.276
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.724	0.276
M13 Other arthritis	0.276	0.724	0.000
M05.8 Other seropositive rheumatoid arthritis	0.275	0.725	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.275	0.725	0.000
M05.2 Rheumatoid vasculitis	0.275	0.725	0.000
M05.1 Rheumatoid lung disease	0.275	0.725	0.000
M05.0 Felty's syndrome	0.275	0.725	0.000
M62.9 Disorder of muscle, unspecified	0.275	0.725	0.000
M62.6 Muscle strain	0.275	0.725	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.275	0.725	0.000
M62.4 Contracture of muscle	0.275	0.725	0.000
M62.3 Immobility syndrome (paraplegic)	0.275	0.725	0.000
M62.2 Ischaemic infarction of muscle	0.275	0.725	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.275	0.725	0.000
M62.0 Diastasis of muscle	0.275	0.725	0.000
M46.46 Discitis, unspecified (Lumbar region)	0.275	0.725	0.000
M40.5 Lordosis, unspecified	0.274	0.725	0.000
M00.9 Pyogenic arthritis, unspecified	0.273	0.726	0.000
M99 Biomechanical lesions, not elsewhere classified	0.273	0.727	0.000
M10.97 Gout, unspecified (Ankle and foot)	0.272	0.728	0.000
E04 Other non-toxic goitre	0.000	0.729	0.271
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.732	0.268
M88.8 Paget's disease of other bones	0.266	0.734	0.000
M88.0 Paget's disease of skull	0.266	0.734	0.000
M14.8 Arthropathies in other specified diseases classified elsewhere	0.265	0.735	0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.265	0.735	0.000
M14.4 Arthropathy in amyloidosis	0.265	0.735	0.000
M14.3 Lipoid dermatoarthritis	0.265	0.735	0.000
M14.2 Diabetic arthropathy	0.265	0.735	0.000
M14.1 Crystal arthropathy in other metabolic disorders	0.265	0.735	0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.265	0.735	0.000
K90.9 Intestinal malabsorption, unspecified	0.000	0.735	0.265
M48.09 Spinal stenosis (Site unspecified)	0.264	0.735	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.736	0.264
E32 Diseases of thymus	0.000	0.736	0.264
E31 Polyglandular dysfunction	0.000	0.736	0.264
E30 Disorders of puberty, not elsewhere classified	0.000	0.736	0.264
E25 Adrenogenital disorders	0.000	0.736	0.264
E20 Hypoparathyroidism	0.000	0.736	0.264
M94.2 Chondromalacia	0.263	0.737	0.000
M62.81 Other specified disorders of muscle (Shoulder region)	0.262	0.738	0.000
M86.6 Other chronic osteomyelitis	0.261	0.739	0.000
M86.5 Other chronic haematogenous osteomyelitis	0.261	0.739	0.000
M86.4 Chronic osteomyelitis with draining sinus	0.261	0.739	0.000
M86.3 Chronic multifocal osteomyelitis	0.261	0.739	0.000
M86.2 Subacute osteomyelitis	0.261	0.739	0.000
M86.1 Other acute osteomyelitis	0.261	0.739	0.000
M86.0 Acute haematogenous osteomyelitis	0.261	0.739	0.000
M66 Spontaneous rupture of synovium and tendon	0.260	0.740	0.000
M10.96 Gout, unspecified (Lower leg)	0.260	0.740	0.000
M46.49 Discitis, unspecified (Site unspecified)	0.258	0.742	0.000
M46.48 Discitis, unspecified (Sacral and sacrococcygeal region)	0.258	0.742	0.000
M46.47 Discitis, unspecified (Lumbosacral region)	0.258	0.742	0.000
M46.45 Discitis, unspecified (Thoracolumbar region)	0.258	0.742	0.000
M46.44 Discitis, unspecified (Thoracic region)	0.258	0.742	0.000
M46.43 Discitis, unspecified (Cervicothoracic region)	0.258	0.742	0.000
M46.42 Discitis, unspecified (Cervical region)	0.258	0.742	0.000
M46.41 Discitis, unspecified (Occipito-atlanto-axial region)	0.258	0.742	0.000
M46.40 Discitis, unspecified (Multiple sites in spine)	0.258	0.742	0.000
E24 Cushing's syndrome	0.000	0.742	0.258
M62.89 Other specified disorders of muscle (Site unspecified)	0.258	0.742	0.000
M67 Other disorders of synovium and tendon	0.257	0.743	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.256	0.744	0.000
M86.87 Other osteomyelitis (Ankle and foot)	0.256	0.744	0.000
M00.8 Arthritis and polyarthritis due to other specified bacterial agents	0.254	0.745	0.000
M00.2 Other streptococcal arthritis and polyarthritis	0.254	0.745	0.000
M00.1 Pneumococcal arthritis and polyarthritis	0.254	0.745	0.000
M00.0 Staphylococcal arthritis and polyarthritis	0.254	0.745	0.000
M07.38 Other psoriatic arthropathies (Other)	0.254	0.745	0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.254	0.745	0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.254	0.745	0.000
M07.34 Other psoriatic arthropathies (Hand)	0.254	0.745	0.000
M07.33 Other psoriatic arthropathies (Forearm)	0.254	0.745	0.000
M07.32 Other psoriatic arthropathies (Upper arm)	0.254	0.745	0.000
M07.31 Other psoriatic arthropathies (Shoulder region)	0.254	0.745	0.000
M49.09 Tuberculosis of spine (Site unspecified)	0.254	0.746	0.000
M49.08 Tuberculosis of spine (Sacral and sacrococcygeal region)	0.254	0.746	0.000
M49.07 Tuberculosis of spine (Lumbosacral region)	0.254	0.746	0.000
M49.06 Tuberculosis of spine (Lumbar region)	0.254	0.746	0.000
M49.05 Tuberculosis of spine (Thoracolumbar region)	0.254	0.746	0.000
M49.04 Tuberculosis of spine (Thoracic region)	0.254	0.746	0.000
M49.03 Tuberculosis of spine (Cervicothoracic region)	0.254	0.746	0.000
M49.02 Tuberculosis of spine (Cervical region)	0.254	0.746	0.000
M49.01 Tuberculosis of spine (Occipito-atlanto-axial region)	0.254	0.746	0.000
M49.00 Tuberculosis of spine (Multiple sites in spine)	0.254	0.746	0.000
M49.19 Brucella spondylitis (Site unspecified)	0.254	0.746	0.000
M49.18 Brucella spondylitis (Sacral and sacrococcygeal region)	0.254	0.746	0.000
M49.17 Brucella spondylitis (Lumbosacral region)	0.254	0.746	0.000
M49.16 Brucella spondylitis (Lumbar region)	0.254	0.746	0.000
M49.15 Brucella spondylitis (Thoracolumbar region)	0.254	0.746	0.000
M49.14 Brucella spondylitis (Thoracic region)	0.254	0.746	0.000
M49.13 Brucella spondylitis (Cervicothoracic region)	0.254	0.746	0.000
M49.12 Brucella spondylitis (Cervical region)	0.254	0.746	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations