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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs9469220
log Bayes Factor = 239.257
Chromosome 6   position 32,658,310  (GRCh37) Explore rs9469220 on Ensembl!
Variant rs9469220 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
D86.9 Sarcoidosis, unspecified
0.000 0.000 1.000
D86 Sarcoidosis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.000 1.000
D80-D89 Certain disorders involving the immune mechanism
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
0.000 0.000 1.000
M06 Other rheumatoid arthritis
1.000 0.000 0.000
D50-D53 Nutritional anaemias
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.999 0.001 0.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
L40 Psoriasis
0.999 0.001 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.999 0.001 0.000
H33 Retinal detachments and breaks
0.000 0.001 0.999
E14.3 With ophthalmic complications
0.000 0.002 0.998
E10.2 With renal complications
0.000 0.002 0.998
E27.1 Primary adrenocortical insufficiency
0.000 0.003 0.997
Chapter VII Diseases of the eye and adnexa
0.000 0.005 0.995
# Top node
0.000 0.006 0.994
L40.5 Arthropathic psoriasis
0.994 0.006 0.000
E27 Other disorders of adrenal gland
0.000 0.006 0.994
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.994 0.006 0.000
H33.2 Serous retinal detachment
0.000 0.006 0.994
M06.0 Seronegative rheumatoid arthritis
0.993 0.007 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.007 0.993
E14.9 Without complications
0.000 0.007 0.993
M05-M14 Inflammatory polyarthropathies
0.991 0.008 0.001
E10.5 With peripheral circulatory complications
0.000 0.008 0.992
D51 Vitamin B12 deficiency anaemia
0.000 0.009 0.991
M05 Seropositive rheumatoid arthritis
0.987 0.012 0.000
M35.3 Polymyalgia rheumatica
0.000 0.015 0.985
M35 Other systemic involvement of connective tissue
0.000 0.016 0.984
M05.9 Seropositive rheumatoid arthritis, unspecified
0.983 0.017 0.000
R31 Unspecified haematuria
0.982 0.018 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.979 0.021 0.000
H33.3 Retinal breaks without detachment
0.000 0.023 0.977
M35.0 Sicca syndrome [Sjogren]
0.000 0.024 0.976
N48 Other disorders of penis
0.974 0.026 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.028 0.972
D50 Iron deficiency anaemia
0.000 0.029 0.971
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.029 0.971
M07 Psoriatic and enteropathic arthropathies
0.967 0.032 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.034 0.966
D50.9 Iron deficiency anaemia, unspecified
0.000 0.035 0.965
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.965 0.035 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.003 0.037 0.961
Chapter II Neoplasms
0.560 0.048 0.393
N48.6 Balanitis xerotica obliterans
0.951 0.049 0.000
M07.3 Other psoriatic arthropathies
0.951 0.049 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.543 0.054 0.403
N48.0 Leukoplakia of penis
0.945 0.055 0.000
K90 Intestinal malabsorption
0.000 0.056 0.944
M07.39 Other psoriatic arthropathies (Site unspecified)
0.941 0.059 0.000
C82.0 Small cleaved cell, follicular
0.940 0.060 0.000
M06.3 Rheumatoid nodule
0.938 0.062 0.000
E50-E64 Other nutritional deficiencies
0.000 0.065 0.935
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.540 0.067 0.393
N48.8 Other specified disorders of penis
0.932 0.068 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.931 0.069 0.000
N47 Redundant prepuce, phimosis and paraphimosis
0.924 0.076 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.078 0.922
L20-L30 Dermatitis and eczema
0.000 0.082 0.918
Chapter VI Diseases of the nervous system
0.000 0.090 0.910
C82.3 Follicular lymphoma grade IIIa
0.909 0.091 0.000
D86.1 Sarcoidosis of lymph nodes
0.000 0.101 0.899
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.899 0.101 0.000
E10.0 With coma
0.000 0.101 0.899
N48.1 Balanoposthitis
0.898 0.102 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.102 0.898
L40-L45 Papulosquamous disorders
0.860 0.103 0.037
E55 Vitamin D deficiency
0.000 0.103 0.897
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.000 0.106 0.894
N48.2 Other inflammatory disorders of penis
0.894 0.106 0.000
H33.4 Traction detachment of retina
0.000 0.106 0.894
L10-L14 Bullous disorders
0.002 0.106 0.891
C82.2 Large cell, follicular
0.892 0.108 0.000
D68 Other coagulation defects
0.000 0.111 0.889
N40-N51 Diseases of male genital organs
0.887 0.113 0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.883 0.117 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.117 0.883
E27.8 Other specified disorders of adrenal gland
0.000 0.120 0.880
L21 Seborrhoeic dermatitis
0.000 0.120 0.880
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.121 0.879
E11.3 With ophthalmic complications
0.000 0.121 0.879
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.878 0.122 0.000
M35.1 Other overlap syndromes
0.000 0.124 0.876
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.128 0.872
D86.0 Sarcoidosis of lung
0.000 0.128 0.872
L13 Other bullous disorders
0.001 0.130 0.869
E55.9 Vitamin D deficiency, unspecified
0.000 0.131 0.869
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.137 0.863
E10.8 With unspecified complications
0.000 0.139 0.861
C44.3 Skin of other and unspecified parts of face
0.861 0.139 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.140 0.860
D52 Folate deficiency anaemia
0.000 0.142 0.858
G37 Other demyelinating diseases of central nervous system
0.000 0.143 0.857
M06.98 Rheumatoid arthritis, unspecified (Other)
0.855 0.145 0.000
L13.0 Dermatitis herpetiformis
0.000 0.146 0.854
L21.9 Seborrhoeic dermatitis, unspecified
0.000 0.147 0.853
E14.8 With unspecified complications
0.000 0.147 0.853
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.000 0.151 0.849
C44 Other malignant neoplasms of skin
0.849 0.151 0.000
E34 Other endocrine disorders
0.000 0.154 0.846
C83 Diffuse non-Hodgkin's lymphoma
0.490 0.156 0.354
E40-E46 Malnutrition
0.000 0.157 0.843
L40.4 Guttate psoriasis
0.842 0.158 0.000
C44.7 Skin of lower limb, including hip
0.841 0.159 0.000
C44.5 Skin of trunk
0.841 0.159 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.163 0.837
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.163 0.837
M20-M25 Other joint disorders
0.000 0.165 0.835
M86-M90 Other osteopathies
0.000 0.166 0.834
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.833 0.167 0.000
N48.5 Ulcer of penis
0.833 0.167 0.000
E14.6 With other specified complications
0.000 0.168 0.832
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.171 0.829
H16 Keratitis
0.000 0.172 0.828
L27 Dermatitis due to substances taken internally
0.000 0.173 0.827
E06 Thyroiditis
0.000 0.173 0.827
E11.5 With peripheral circulatory complications
0.000 0.174 0.826
D69 Purpura and other haemorrhagic conditions
0.000 0.175 0.825
M21 Other acquired deformities of limbs
0.000 0.177 0.823
D53 Other nutritional anaemias
0.000 0.182 0.818
H06.2 Dysthyroid exophthalmos
0.000 0.183 0.817
M05.8 Other seropositive rheumatoid arthritis
0.815 0.184 0.000
M21.0 Valgus deformity, not elsewhere classified
0.000 0.185 0.815
H05 Disorders of orbit
0.000 0.185 0.815
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.187 0.813
M86 Osteomyelitis
0.000 0.189 0.811
D68.5 Primary Thrombophilia
0.000 0.189 0.811
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.000 0.192 0.808
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.807 0.193 0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.807 0.193 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.194 0.806
N48.9 Disorder of penis, unspecified
0.804 0.196 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.803 0.197 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.796 0.204 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.794 0.206 0.000
C82.4 Follicular lymphoma grade IIIb
0.791 0.209 0.000
H04 Disorders of lachrymal system
0.000 0.213 0.787
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.216 0.784
E10.6 With other specified complications
0.000 0.217 0.783
C82.1 Mixed small cleaved and large cell, follicular
0.782 0.218 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.218 0.782
D82 Immunodeficiency associated with other major defects
0.000 0.218 0.781
D67 Hereditary factor IX deficiency
0.000 0.219 0.781
M89 Other disorders of bone
0.000 0.220 0.780
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.463 0.220 0.317
M06.37 Rheumatoid nodule (Ankle and foot)
0.779 0.221 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.779 0.221 0.000
E11.1 With ketoacidosis
0.000 0.222 0.778
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.226 0.774
E07 Other disorders of thyroid
0.000 0.228 0.772
M06.34 Rheumatoid nodule (Hand)
0.769 0.231 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.232 0.768
L42 Pityriasis rosea
0.752 0.232 0.016
M11 Other crystal arthropathies
0.766 0.234 0.000
E14.2 Withrenal complications
0.000 0.235 0.765
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.765 0.235 0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.764 0.235 0.000
L40.0 Psoriasis vulgaris
0.761 0.239 0.000
M86.9 Osteomyelitis, unspecified
0.000 0.241 0.759
G36 Other acute disseminated demyelination
0.000 0.241 0.759
E31 Polyglandular dysfunction
0.000 0.241 0.759
L93 Lupus erythematosus
0.000 0.241 0.759
E34.0 Carcinoid syndrome
0.000 0.243 0.757
D68.8 Other specified coagulation defects
0.000 0.243 0.757
M60-M63 Disorders of muscles
0.000 0.243 0.757
D52.9 Folate deficiency anaemia, unspecified
0.000 0.244 0.756
E14.1 With ketoacidosis
0.000 0.245 0.755
H31 Other disorders of choroid
0.000 0.245 0.755
C43-C44 Melanoma and other malignant neoplasms of skin
0.661 0.245 0.094
H47 Other disorders of optic [2nd] nerve and visual pathways
0.000 0.246 0.754
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.247 0.753
D86.3 Sarcoidosis of skin
0.000 0.247 0.753
H16.0 Corneal ulcer
0.000 0.248 0.752
H18 Other disorders of cornea
0.000 0.249 0.751
L23 Allergic contact dermatitis
0.000 0.250 0.750
E53 Deficiency of other B group vitamins
0.000 0.251 0.749
M07.36 Other psoriatic arthropathies (Lower leg)
0.748 0.251 0.000
H33.1 Retinoschisis and retinal cysts
0.000 0.251 0.748
M06.33 Rheumatoid nodule (Forearm)
0.747 0.253 0.000
H04.8 Other disorders of lachrymal system
0.000 0.253 0.747
N44 Torsion of testis
0.745 0.255 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.744 0.256 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.257 0.742
L40.1 Generalised pustular psoriasis
0.742 0.258 0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.737 0.263 0.000
D84 Other immunodeficiencies
0.000 0.263 0.737
M08 Juvenile arthritis
0.736 0.264 0.001
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.000 0.264 0.736
M35.2 Behcet's disease
0.000 0.264 0.736
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.732 0.268 0.000
H05.2 Exophthalmic conditions
0.000 0.268 0.732
M06.4 Inflammatory polyarthropathy
0.731 0.269 0.000
E46 Unspecified protein-energy malnutrition
0.000 0.269 0.731
L89 Decubitus ulcer
0.000 0.270 0.730
M89.8 Other specified disorders of bone
0.000 0.271 0.729
L25 Unspecified contact dermatitis
0.000 0.271 0.729
H18.6 Keratoconus
0.000 0.272 0.728
L50-L54 Urticaria and erythema
0.001 0.274 0.725
M87 Osteonecrosis
0.000 0.274 0.726
L60-L75 Disorders of skin appendages
0.000 0.274 0.725
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.725 0.275 0.000
L27.0 Generalised skin eruption due to drugs and medicaments
0.000 0.275 0.725
M35.8 Other specified systemic involvement of connective tissue
0.000 0.277 0.723
E20 Hypoparathyroidism
0.000 0.280 0.720
N48.3 Priapism
0.718 0.282 0.000
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
D81 Combined immunodeficiencies
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.717 0.283 0.000
M06.1 Adult-onset Still's disease
0.717 0.283 0.000
L40.2 Acrodermatitis continua
0.716 0.284 0.000
C82.6 Cutaneous follicle centre lymphoma
0.716 0.284 0.000
C82.5 Diffuse follicle centre lymphoma
0.716 0.284 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.716 0.284 0.000
L93.0 Discoid lupus erythematosus
0.000 0.285 0.715
L40.3 Pustulosis palmaris et plantaris
0.714 0.286 0.000
M32 Systemic lupus erythematosus
0.000 0.287 0.713
E27.5 Adrenomedullary hyperfunction
0.000 0.287 0.713
E27.0 Other adrenocortical overactivity
0.000 0.287 0.713
M06.08 Seronegative rheumatoid arthritis (Other)
0.712 0.288 0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.712 0.288 0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.712 0.288 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.288 0.712
E32 Diseases of thymus
0.000 0.288 0.712
E30 Disorders of puberty, not elsewhere classified
0.000 0.288 0.712
M09 Juvenile arthritis in diseases classified elsewhere
0.711 0.288 0.001
D51.2 Transcobalamin II deficiency
0.000 0.289 0.710
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.289 0.710
E14.5 With peripheral circulatory complications
0.000 0.291 0.709
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.708 0.292 0.000
M05.0 Felty's syndrome
0.708 0.292 0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.293 0.707
M89.87 Other specified disorders of bone (Ankle and foot)
0.000 0.293 0.707
M05.1 Rheumatoid lung disease
0.706 0.294 0.000
M07.38 Other psoriatic arthropathies (Other)
0.706 0.294 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.295 0.705
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.295 0.705
M35.5 Multifocal fibrosclerosis
0.000 0.295 0.705
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.295 0.705
D50.1 Sideropenic dysphagia
0.000 0.295 0.705
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.705 0.295 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.298 0.702
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.702 0.298 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.701 0.299 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.701 0.299 0.000
E11.2 With renal complications
0.000 0.299 0.701
H16.4 Corneal neovascularisation
0.000 0.299 0.701
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.700 0.300 0.000
L11 Other acantholytic disorders
0.001 0.300 0.699
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.300 0.700
M62 Other disorders of muscle
0.000 0.301 0.699
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.699 0.301 0.000
E07.8 Other specified disorders of thyroid
0.000 0.305 0.695
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.000 0.306 0.694
L89.9 Decubitus ulcer and pressure area, unspecified
0.000 0.306 0.694
M07.5 Arthropathy in ulcerative colitis
0.693 0.306 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.693 0.306 0.000
M07.2 Psoriatic spondylitis
0.693 0.306 0.000
M07.1 Arthritis mutilans
0.693 0.306 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.693 0.306 0.000
L43 Lichen planus
0.683 0.307 0.010
H46 Optic neuritis
0.000 0.310 0.690
E06.9 Thyroiditis, unspecified
0.000 0.310 0.690
M86.97 Osteomyelitis, unspecified (Ankle and foot)
0.000 0.311 0.689
M35.7 Hypermobility syndrome
0.000 0.311 0.689
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.312 0.688
M21.8 Other specified acquired deformities of limbs
0.000 0.312 0.688
D53.9 Nutritional anaemia, unspecified
0.000 0.312 0.688
H16.9 Keratitis, unspecified
0.000 0.314 0.686
E51 Thiamine deficiency
0.000 0.314 0.685
M05.2 Rheumatoid vasculitis
0.684 0.316 0.000
M07.33 Other psoriatic arthropathies (Forearm)
0.682 0.318 0.000
M07.32 Other psoriatic arthropathies (Upper arm)
0.682 0.318 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.000 0.318 0.682
M07.31 Other psoriatic arthropathies (Shoulder region)
0.682 0.318 0.000
L40.8 Other psoriasis
0.681 0.318 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.000 0.319 0.681
M06.04 Seronegative rheumatoid arthritis (Hand)
0.680 0.320 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.389 0.322 0.289
C94 Other leukaemias of specified cell type
0.389 0.322 0.289
M89.3 Hypertrophy of bone
0.000 0.322 0.678
E11.6 With other specified complications
0.000 0.323 0.677
K90.8 Other intestinal malabsorption
0.000 0.323 0.677
K90.3 Pancreatic steatorrhoea
0.000 0.323 0.677
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.323 0.677
K90.1 Tropical sprue
0.000 0.323 0.677
L44 Other papulosquamous disorders
0.652 0.324 0.024
H05.0 Acute inflammation of orbit
0.000 0.324 0.676
M62.8 Other specified disorders of muscle
0.000 0.324 0.676
H30 Chorioretinal inflammation
0.000 0.325 0.675
D68.0 Von Willebrand's disease
0.000 0.325 0.675
H04.3 Acute and unspecified inflammation of lachrymal passages
0.000 0.325 0.675
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)
0.000 0.326 0.674
N00-N08 Glomerular diseases
0.000 0.327 0.673
M07.6 Other enteropathic arthropathies
0.672 0.327 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.672 0.327 0.000
M06.38 Rheumatoid nodule (Other)
0.672 0.327 0.000
M06.36 Rheumatoid nodule (Lower leg)
0.672 0.327 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.672 0.327 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.672 0.327 0.000
M86.6 Other chronic osteomyelitis
0.000 0.329 0.671
M86.8 Other osteomyelitis
0.000 0.329 0.671
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.329 0.671
E63 Other nutritional deficiencies
0.000 0.329 0.671
E50 Vitamin A deficiency
0.000 0.329 0.671
E60 Dietary zinc deficiency
0.000 0.329 0.671
E59 Dietary selenium deficiency
0.000 0.329 0.671
E54 Ascorbic acid deficiency
0.000 0.329 0.671
E52 Niacin deficiency [pellagra]
0.000 0.329 0.671
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.387 0.331 0.282
D69.4 Other primary thrombocytopenia
0.000 0.331 0.669
D83 Common variable immunodeficiency
0.000 0.333 0.667
H53-H54 Visual disturbances and blindness
0.000 0.333 0.667
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.334 0.666
C86 Other specified types of T/NK-cell lymphoma
0.376 0.335 0.289
E61 Deficiency of other nutrient elements
0.000 0.336 0.664
E28 Ovarian dysfunction
0.000 0.337 0.663
D68.4 Acquired coagulation factor deficiency
0.000 0.338 0.662
C33 Malignant neoplasm of trachea
0.401 0.339 0.260
L71 Rosacea
0.000 0.339 0.661
E11.7 With multiple complications
0.000 0.339 0.661
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.339 0.660
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.340 0.660
L28 Lichen simplex chronicus and prurigo
0.000 0.341 0.659
E22 Hyperfunction of pituitary gland
0.000 0.342 0.658
L24 Irritant contact dermatitis
0.000 0.342 0.658
L26 Exfoliative dermatitis
0.000 0.342 0.658
L22 Diaper [napkin] dermatitis
0.000 0.342 0.658
L27.1 Localised skin eruption due to drugs and medicaments
0.000 0.344 0.656
C31 Malignant neoplasm of accessory sinuses
0.365 0.344 0.291
C93 Monocytic leukaemia
0.327 0.347 0.326
Chapter XIV Diseases of the genitourinary system
0.000 0.348 0.652
L20 Atopic dermatitis
0.000 0.349 0.651
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.000 0.350 0.650
M06.8 Other specified rheumatoid arthritis
0.648 0.351 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.648 0.352 0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)
0.648 0.352 0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.647 0.353 0.000
M86.95 Osteomyelitis, unspecified (Pelvic region and thigh)
0.000 0.354 0.646
C37 Malignant neoplasm of thymus
0.382 0.354 0.265
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.354 0.646
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)
0.646 0.354 0.000
M87.9 Osteonecrosis, unspecified
0.000 0.354 0.646
E06.1 Subacute thyroiditis
0.000 0.356 0.644
M00-M03 Infectious arthropathies
0.000 0.357 0.643
L45 Papulosquamous disorders in diseases classified elsewhere
0.617 0.357 0.026
L84 Corns and callosities
0.000 0.357 0.643
E55.0 Rickets, active
0.000 0.357 0.643
C30 Malignant neoplasm of nasal cavity and middle ear
0.381 0.357 0.262
L23.9 Allergic contact dermatitis, unspecified cause
0.000 0.357 0.643
C95 Leukaemia of unspecified cell type
0.364 0.359 0.277
L14 Bullous disorders in diseases classified elsewhere
0.002 0.359 0.639
L41 Parapsoriasis
0.615 0.359 0.026
E27.2 Addisonian crisis
0.000 0.360 0.640
M32.1 Systemic lupus erythematosus with organ or system involvement
0.000 0.360 0.640
N08.5 Glomerular disorders in systemic connective tissue disorders
0.000 0.362 0.638
E06.5 Other chronic thyroiditis
0.000 0.362 0.638
H15 Disorders of sclera
0.000 0.363 0.637
G50-G59 Nerve, nerve root and plexus disorders
0.000 0.363 0.637
L72 Follicular cysts of skin and subcutaneous tissue
0.000 0.365 0.635
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.365 0.635
G59 Mononeuropathy in diseases classified elsewhere
0.000 0.366 0.634
G59.0 Diabetic mononeuropathy
0.000 0.366 0.634
H31.0 Chorioretinal scars
0.000 0.367 0.633
L81 Other disorders of pigmentation
0.000 0.368 0.632
G80-G83 Cerebral palsy and other paralytic syndromes
0.000 0.369 0.631
L21.8 Other seborrhoeic dermatitis
0.000 0.369 0.631
L21.1 Seborrhoeic infantile dermatitis
0.000 0.369 0.631
L21.0 Seborrhoea capitis
0.000 0.369 0.631
M21.3 Wrist or foot drop (acquired)
0.000 0.369 0.631
C38 Malignant neoplasm of heart, mediastinum and pleura
0.341 0.370 0.288
N04 Nephrotic syndrome
0.000 0.371 0.629
D68.9 Coagulation defect, unspecified
0.000 0.372 0.628
E05.8 Other thyrotoxicosis
0.000 0.374 0.626
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.000 0.374 0.625
L27.2 Dermatitis due to ingested food
0.000 0.375 0.625
C40-C41 Malignant neoplasms of bone and articular cartilage
0.352 0.375 0.274
D82.1 Di George's syndrome
0.000 0.375 0.625
H05.4 Enophthalmos
0.000 0.375 0.625
E11.4 With neurological complications
0.000 0.376 0.624
D86.8 Sarcoidosis of other and combined sites
0.000 0.376 0.624
L13.9 Bullous disorder, unspecified
0.001 0.376 0.623
L13.8 Other specified bullous disorders
0.001 0.376 0.623
L13.1 Subcorneal pustular dermatitis
0.001 0.376 0.623
M21.1 Varus deformity, not elsewhere classified
0.000 0.376 0.624
H47.0 Disorders of optic nerve, not elsewhere classified
0.000 0.377 0.623
H03 Disorders of eyelid in diseases classified elsewhere
0.000 0.377 0.623
H04.1 Other disorders of lachrymal gland
0.000 0.377 0.623
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.377 0.623
L83 Acanthosis nigricans
0.000 0.377 0.623
C44.0 Skin of lip
0.621 0.379 0.000
E34.8 Other specified endocrine disorders
0.000 0.379 0.621
H16.3 Interstitial and deep keratitis
0.000 0.380 0.620
N17-N19 Renal failure
0.000 0.381 0.619
D52.8 Other folate deficiency anaemias
0.000 0.385 0.615
D52.1 Drug-induced folate deficiency anaemia
0.000 0.385 0.615
D52.0 Dietary folate deficiency anaemia
0.000 0.385 0.615
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.350 0.385 0.265
G37.5 Concentric sclerosis [Balo]
0.000 0.385 0.614
G37.4 Subacute necrotising myelitis
0.000 0.385 0.614
G37.2 Central pontine myelinolysis
0.000 0.385 0.614
G37.1 Central demyelination of corpus callosum
0.000 0.385 0.614
G37.0 Diffuse sclerosis
0.000 0.385 0.614
E16.1 Other hypoglycaemia
0.000 0.386 0.614
D68.6 Other Thrombophilia
0.000 0.387 0.612
D69.5 Secondary thrombocytopenia
0.000 0.388 0.612
E34.9 Endocrine disorder, unspecified
0.000 0.388 0.612
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere
0.000 0.388 0.612
E53.9 Vitamin B deficiency, unspecified
0.000 0.389 0.611
H47.3 Other disorders of optic disk
0.000 0.390 0.610
D00-D09 In situ neoplasms
0.609 0.390 0.001
H06.3 Other disorders of orbit in diseases classified elsewhere
0.000 0.391 0.609
H06.1 Parasitic infestation of orbit in diseases classified elsewhere
0.000 0.391 0.609
H06.0 Disorders of lachrymal system in diseases classified elsewhere
0.000 0.391 0.609
C44.8 Overlapping lesion of skin
0.609 0.391 0.000
E34.5 Androgen resistance syndrome
0.000 0.393 0.607
E34.4 Constitutional tall stature
0.000 0.393 0.607
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.393 0.607
E34.1 Other hypersecretion of intestinal hormones
0.000 0.393 0.607
E29 Testicular dysfunction
0.000 0.394 0.606
G36.0 Neuromyelitis optica [Devic]
0.000 0.394 0.606
C83.6 Undifferentiated (diffuse)
0.352 0.394 0.254
C83.5 Lymphoblastic (diffuse)
0.352 0.394 0.254
C83.4 Immunoblastic (diffuse)
0.352 0.394 0.254
C83.2 Mixed small and large cell (diffuse)
0.352 0.394 0.254
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.395 0.605
E45 Retarded development following protein-energy malnutrition
0.000 0.395 0.605
E43 Unspecified severe protein-energy malnutrition
0.000 0.395 0.605
E42 Marasmic kwashiorkor
0.000 0.395 0.605
E41 Nutritional marasmus
0.000 0.395 0.605
E40 Kwashiorkor
0.000 0.395 0.605
M86.4 Chronic osteomyelitis with draining sinus
0.000 0.396 0.604
M33 Dermatopolymyositis
0.000 0.397 0.603
D07 Carcinoma in situ of other and unspecified genital organs
0.602 0.398 0.000
M86.1 Other acute osteomyelitis
0.000 0.399 0.601
D89.3 Immune reconstitution syndrome
0.000 0.400 0.600
M87.2 Osteonecrosis due to previous trauma
0.000 0.400 0.600
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.005 0.400 0.595
N51 Disorders of male genital organs in diseases classified elsewhere
0.598 0.401 0.000
L53 Other erythematous conditions
0.000 0.402 0.598
C32 Malignant neoplasm of larynx
0.548 0.402 0.050
M89.37 Hypertrophy of bone (Ankle and foot)
0.000 0.402 0.598
L72.8 Other follicular cysts of skin and subcutaneous tissue
0.000 0.403 0.597
D07.1 Vulva
0.596 0.404 0.000
M62.89 Other specified disorders of muscle (Site unspecified)
0.000 0.404 0.596
H54 Blindness and low vision
0.000 0.405 0.595
E14.4 With neurological complications
0.000 0.405 0.594
L95 Vasculitis limited to skin, not elsewhere classified
0.000 0.406 0.594
L89.3 Stage IV decubitus ulcer
0.000 0.406 0.594
L71.1 Rhinophyma
0.000 0.406 0.594
L27.9 Dermatitis due to unspecified substance taken internally
0.000 0.407 0.593
L27.8 Dermatitis due to other substances taken internally
0.000 0.407 0.593
L25.9 Unspecified contact dermatitis, unspecified cause
0.000 0.407 0.593
M11.9 Crystal arthropathy, unspecified
0.592 0.407 0.000
E06.4 Drug-induced thyroiditis
0.000 0.407 0.593
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.407 0.593
E06.0 Acute thyroiditis
0.000 0.407 0.593
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.408 0.592
D69.8 Other specified haemorrhagic conditions
0.000 0.409 0.591
C84 Peripheral and cutaneous T-cell lymphomas
0.329 0.409 0.262
E31.0 Autoimmune polyglandular failure
0.000 0.409 0.591
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.000 0.409 0.591
M86.86 Other osteomyelitis (Lower leg)
0.000 0.410 0.590
L72.1 Trichilemmal cyst
0.000 0.410 0.590
N19 Unspecified renal failure
0.000 0.411 0.589

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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