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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs986522
log Bayes Factor = 19.6927
Chromosome 6   position 33,135,962  (GRCh37) Explore rs986522 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.035 0.965
E10.2 With renal complications
0.000 0.058 0.942
E10.5 With peripheral circulatory complications
0.000 0.159 0.841
E10.6 With other specified complications
0.000 0.167 0.833
E10-E14 Diabetes mellitus
0.000 0.176 0.824
E10.7 With multiple complications
0.000 0.246 0.754
E27.1 Primary adrenocortical insufficiency
0.000 0.256 0.744
E11 Non-insulin-dependent diabetes mellitus
0.000 0.258 0.742
E10.8 With unspecified complications
0.000 0.263 0.737
E11.4 With neurological complications
0.000 0.291 0.709
E27 Other disorders of adrenal gland
0.000 0.300 0.700
E10.0 With coma
0.000 0.304 0.696
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.324 0.676
E20-E35 Disorders of other endocrine glands
0.000 0.326 0.674
E11.3 With ophthalmic complications
0.000 0.328 0.672
E11.6 With other specified complications
0.000 0.340 0.660
E22 Hyperfunction of pituitary gland
0.000 0.369 0.631
E10.4 With neurological complications
0.000 0.371 0.629
E27.2 Addisonian crisis
0.000 0.388 0.612
E11.0 With coma
0.000 0.397 0.603
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.397 0.602
E12 Malnutrition-related diabetes mellitus
0.000 0.409 0.591
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.430 0.570
E13 Other specified diabetes mellitus
0.000 0.442 0.558
E22.1 Hyperprolactinaemia
0.000 0.446 0.554
E16 Other disorders of pancreatic internal secretion
0.000 0.450 0.550
E16.2 Hypoglycaemia, unspecified
0.000 0.476 0.524
E11.2 With renal complications
0.000 0.487 0.513
E29 Testicular dysfunction
0.000 0.494 0.506
E40-E46 Malnutrition
0.000 0.496 0.504
E27.5 Adrenomedullary hyperfunction
0.000 0.498 0.502
E27.0 Other adrenocortical overactivity
0.000 0.498 0.502
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.508 0.492
E25 Adrenogenital disorders
0.000 0.508 0.491
E11.7 With multiple complications
0.000 0.516 0.484
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.516 0.483
E32 Diseases of thymus
0.000 0.516 0.483
E31 Polyglandular dysfunction
0.000 0.516 0.483
E30 Disorders of puberty, not elsewhere classified
0.000 0.516 0.483
E50-E64 Other nutritional deficiencies
0.000 0.525 0.475
E11.8 With unspecified complications
0.000 0.530 0.470
E28 Ovarian dysfunction
0.000 0.537 0.462
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.544 0.456
E27.9 Disorder of adrenal gland, unspecified
0.000 0.545 0.455
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.547 0.453
E22.8 Other hyperfunction of pituitary gland
0.000 0.547 0.453
E26 Hyperaldosteronism
0.000 0.548 0.452
E20 Hypoparathyroidism
0.000 0.555 0.445
E11.1 With ketoacidosis
0.000 0.558 0.442
E15 Nondiabetic hypoglycaemic coma
0.000 0.568 0.432
E12.9 Without complications
0.000 0.576 0.424
E12.8 With unspecified complications
0.000 0.576 0.424
E12.7 With multiple complications
0.000 0.576 0.424
E12.6 With other specified complications
0.000 0.576 0.424
E12.5 With peripheral circulatory complications
0.000 0.576 0.424
E12.4 With neurological complications
0.000 0.576 0.424
E12.3 With ophthalmic complications
0.000 0.576 0.424
E12.2 With renal complications
0.000 0.576 0.424
E12.1 With ketoacidosis
0.000 0.576 0.424
E12.0 With coma
0.000 0.576 0.424
E53 Deficiency of other B group vitamins
0.000 0.578 0.422
E22.0 Acromegaly and pituitary gigantism
0.000 0.578 0.422
E13.3 With ophthalmic complications
0.000 0.583 0.417
E29.1 Testicular hypofunction
0.000 0.591 0.409
E13.8 With unspecified complications
0.000 0.600 0.400
E13.7 With multiple complications
0.000 0.600 0.400
E13.6 With other specified complications
0.000 0.600 0.400
E13.5 With peripheral circulatory complications
0.000 0.600 0.400
E13.4 With neurological complications
0.000 0.600 0.400
E13.2 With renal complications
0.000 0.600 0.400
E13.1 With ketoacidosis
0.000 0.600 0.400
E13.0 With coma
0.000 0.600 0.400
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.605 0.395
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.605 0.395
E16.4 Abnormal secretion of gastrin
0.000 0.605 0.395
E16.3 Increased secretion of glucagon
0.000 0.605 0.395
E53.8 Deficiency of other specified B group vitamins
0.000 0.615 0.385
E46 Unspecified protein-energy malnutrition
0.000 0.619 0.381
E28.3 Primary ovarian failure
0.000 0.624 0.376
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.627 0.373
E51 Thiamine deficiency
0.000 0.635 0.365
E29.8 Other testicular dysfunction
0.000 0.637 0.363
E29.0 Testicular hyperfunction
0.000 0.637 0.363
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.639 0.361
E45 Retarded development following protein-energy malnutrition
0.000 0.639 0.361
E43 Unspecified severe protein-energy malnutrition
0.000 0.639 0.361
E42 Marasmic kwashiorkor
0.000 0.639 0.361
E41 Nutritional marasmus
0.000 0.639 0.361
E40 Kwashiorkor
0.000 0.639 0.361
E54 Ascorbic acid deficiency
0.000 0.639 0.361
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.639 0.360
E27.8 Other specified disorders of adrenal gland
0.000 0.641 0.359
E16.1 Other hypoglycaemia
0.000 0.644 0.355
E25.9 Adrenogenital disorder, unspecified
0.000 0.647 0.352
E25.8 Other adrenogenital disorders
0.000 0.647 0.352
E34 Other endocrine disorders
0.000 0.653 0.347
E30.9 Disorder of puberty, unspecified
0.000 0.653 0.347
E30.8 Other disorders of puberty
0.000 0.653 0.347
E30.1 Precocious puberty
0.000 0.653 0.347
E30.0 Delayed puberty
0.000 0.653 0.347
E31.9 Polyglandular dysfunction, unspecified
0.000 0.653 0.347
E31.8 Other polyglandular dysfunction
0.000 0.653 0.347
E31.1 Polyglandular hyperfunction
0.000 0.653 0.347
E31.0 Autoimmune polyglandular failure
0.000 0.653 0.347
E32.9 Disease of thymus, unspecified
0.000 0.653 0.347
E32.8 Other diseases of thymus
0.000 0.653 0.347
E32.1 Abscess of thymus
0.000 0.653 0.347
E32.0 Persistent hyperplasia of thymus
0.000 0.653 0.347
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.653 0.347
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.653 0.347
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.653 0.347
E13.9 Without complications
0.000 0.655 0.345
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.660 0.340
E63 Other nutritional deficiencies
0.000 0.660 0.340
E50 Vitamin A deficiency
0.000 0.660 0.340
E60 Dietary zinc deficiency
0.000 0.660 0.340
E59 Dietary selenium deficiency
0.000 0.660 0.340
E52 Niacin deficiency [pellagra]
0.000 0.660 0.340
E58 Dietary calcium deficiency
0.000 0.665 0.335
E14 Unspecified diabetes mellitus
0.000 0.668 0.332
E28.9 Ovarian dysfunction, unspecified
0.000 0.668 0.332
E28.8 Other ovarian dysfunction
0.000 0.668 0.332
E28.1 Androgen excess
0.000 0.668 0.332
E28.0 Oestrogen excess
0.000 0.668 0.332
E26.0 Primary hyperaldosteronism
0.000 0.670 0.330
E29.9 Testicular dysfunction, unspecified
0.000 0.671 0.329
E26.8 Other hyperaldosteronism
0.000 0.676 0.324
E26.1 Secondary hyperaldosteronism
0.000 0.676 0.324
E20.8 Other hypoparathyroidism
0.000 0.681 0.319
E20.1 Pseudohypoparathyroidism
0.000 0.681 0.319
E20.0 Idiopathic hypoparathyroidism
0.000 0.681 0.319
E56 Other vitamin deficiencies
0.000 0.688 0.312
E24 Cushing's syndrome
0.000 0.691 0.309
E53.9 Vitamin B deficiency, unspecified
0.000 0.697 0.303
E53.1 Pyridoxine deficiency
0.000 0.697 0.303
E53.0 Riboflavin deficiency
0.000 0.697 0.303
E51.2 Wernicke's encephalopathy
0.000 0.713 0.287
E26.9 Hyperaldosteronism, unspecified
0.000 0.715 0.284
E20.9 Hypoparathyroidism, unspecified
0.000 0.719 0.281
K90 Intestinal malabsorption
0.000 0.725 0.275
E14.3 With ophthalmic complications
0.000 0.729 0.271
E23 Hypofunction and other disorders of pituitary gland
0.000 0.732 0.268
E55 Vitamin D deficiency
0.000 0.734 0.265
E51.9 Thiamine deficiency, unspecified
0.000 0.738 0.262
E51.8 Other manifestations of thiamine deficiency
0.000 0.738 0.262
E51.1 Beriberi
0.000 0.738 0.262
E14.2 Withrenal complications
0.000 0.739 0.260
E44.1 Mild protein-energy malnutrition
0.000 0.741 0.259
E44.0 Moderate protein-energy malnutrition
0.000 0.741 0.259
E34.5 Androgen resistance syndrome
0.000 0.751 0.249
E34.4 Constitutional tall stature
0.000 0.751 0.249
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.751 0.249
E34.1 Other hypersecretion of intestinal hormones
0.000 0.751 0.249
E14.6 With other specified complications
0.000 0.753 0.247
E34.8 Other specified endocrine disorders
0.000 0.754 0.246
E34.3 Short stature, not elsewhere classified
0.000 0.755 0.245
E50.9 Vitamin A deficiency, unspecified
0.000 0.756 0.244
E50.8 Other manifestations of vitamin A deficiency
0.000 0.756 0.244
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.756 0.244
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.756 0.244
E50.5 Vitamin A deficiency with night blindness
0.000 0.756 0.244
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.756 0.244
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.756 0.244
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.756 0.244
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.756 0.244
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.756 0.244
E63.9 Nutritional deficiency, unspecified
0.000 0.756 0.244
E63.8 Other specified nutritional deficiencies
0.000 0.756 0.244
E63.1 Imbalance of constituents of food intake
0.000 0.756 0.244
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.756 0.244
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.756 0.244
E64.8 Sequelae of other nutritional deficiencies
0.000 0.756 0.244
E64.3 Sequelae of rickets
0.000 0.756 0.244
E64.2 Sequelae of vitamin C deficiency
0.000 0.756 0.244
E64.1 Sequelae of vitamin A deficiency
0.000 0.756 0.244
E64.0 Sequelae of protein-energy malnutrition
0.000 0.756 0.244
E14.5 With peripheral circulatory complications
0.000 0.761 0.239
E14.7 With multiple complications
0.000 0.762 0.238
E14.0 With coma
0.000 0.762 0.238
E11.5 With peripheral circulatory complications
0.000 0.763 0.237
E28.2 Polycystic ovarian syndrome
0.000 0.768 0.232
E56.9 Vitamin deficiency, unspecified
0.000 0.776 0.224
E56.8 Deficiency of other vitamins
0.000 0.776 0.224
E56.0 Deficiency of vitamin E
0.000 0.776 0.224
E24.8 Other Cushing's syndrome
0.000 0.778 0.221
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.778 0.221
E24.3 Ectopic ACTH syndrome
0.000 0.778 0.221
E24.1 Nelson's syndrome
0.000 0.778 0.221
E00-E07 Disorders of thyroid gland
0.001 0.784 0.215
E65-E68 Obesity and other hyperalimentation
0.000 0.786 0.214
E14.8 With unspecified complications
0.000 0.786 0.213
E24.0 Pituitary-dependent Cushing's disease
0.000 0.790 0.209
E23.7 Disorder of pituitary gland, unspecified
0.000 0.794 0.206
E14.1 With ketoacidosis
0.000 0.795 0.205
K90.8 Other intestinal malabsorption
0.000 0.796 0.204
E34.0 Carcinoid syndrome
0.000 0.799 0.201
E61 Deficiency of other nutrient elements
0.001 0.799 0.201
E34.9 Endocrine disorder, unspecified
0.000 0.800 0.200
E24.2 Drug-induced Cushing's syndrome
0.000 0.801 0.198
K90.3 Pancreatic steatorrhoea
0.000 0.803 0.197
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.803 0.197
K90.1 Tropical sprue
0.000 0.803 0.197
E23.6 Other disorders of pituitary gland
0.000 0.803 0.197
E56.1 Deficiency of vitamin K
0.000 0.804 0.195
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.808 0.192
E23.1 Drug-induced hypopituitarism
0.000 0.808 0.192
E55.0 Rickets, active
0.000 0.809 0.190
K90.9 Intestinal malabsorption, unspecified
0.000 0.810 0.190
E06 Thyroiditis
0.000 0.810 0.189
E14.4 With neurological complications
0.000 0.814 0.185
E04 Other non-toxic goitre
0.000 0.834 0.166
M35.0 Sicca syndrome [Sjogren]
0.000 0.835 0.165
E06.3 Autoimmune thyroiditis
0.000 0.839 0.161
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.001 0.845 0.154
E00 Congenital iodine-deficiency syndrome
0.001 0.845 0.154
E06.9 Thyroiditis, unspecified
0.000 0.846 0.154
E67 Other hyperalimentation
0.000 0.846 0.154
E68 Sequelae of hyperalimentation
0.000 0.846 0.154
E02 Subclinical iodine-deficiency hypothyroidism
0.001 0.854 0.145
E61.9 Deficiency of nutrient element, unspecified
0.001 0.856 0.144
E61.8 Deficiency of other specified nutrient elements
0.001 0.856 0.144
E61.7 Deficiency of multiple nutrient elements
0.001 0.856 0.144
E61.6 Vanadium deficiency
0.001 0.856 0.144
E61.5 Molybdenum deficiency
0.001 0.856 0.144
E61.4 Chromium deficiency
0.001 0.856 0.144
E61.3 Manganese deficiency
0.001 0.856 0.144
E61.0 Copper deficiency
0.001 0.856 0.144
R29.6 Tendency to fall, not elsewhere classified
0.000 0.856 0.144
E04.1 Non-toxic single thyroid nodule
0.000 0.857 0.143
E06.5 Other chronic thyroiditis
0.000 0.859 0.141
E06.4 Drug-induced thyroiditis
0.000 0.864 0.136
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.864 0.136
E06.0 Acute thyroiditis
0.000 0.864 0.136
E61.2 Magnesium deficiency
0.001 0.866 0.133
E06.1 Subacute thyroiditis
0.000 0.867 0.133
E24.9 Cushing's syndrome, unspecified
0.001 0.872 0.127
E04.2 Non-toxic multinodular goitre
0.000 0.873 0.127
E04.0 Non-toxic diffuse goitre
0.000 0.878 0.121
E04.8 Other specified non-toxic goitre
0.000 0.881 0.119
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.882 0.118
E55.9 Vitamin D deficiency, unspecified
0.000 0.884 0.115
E23.0 Hypopituitarism
0.000 0.885 0.115
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.001 0.889 0.110
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.001 0.889 0.110
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.001 0.889 0.110
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.001 0.889 0.110
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.001 0.889 0.110
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.001 0.889 0.110
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.001 0.889 0.110
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.001 0.889 0.110
E67.8 Other specified hyperalimentation
0.000 0.889 0.110
E67.3 Hypervitaminosis D
0.000 0.889 0.110
E67.2 Megavitamin-B6 syndrome
0.000 0.889 0.110
E67.1 Hypercarotenaemia
0.000 0.889 0.110
E67.0 Hypervitaminosis A
0.000 0.889 0.110
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.896 0.104
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.898 0.102
E65 Localised adiposity
0.000 0.902 0.097
E23.2 Diabetes insipidus
0.001 0.920 0.079
E21.2 Other hyperparathyroidism
0.000 0.921 0.079
E04.9 Non-toxic goitre, unspecified
0.000 0.922 0.078
E05.5 Thyroid crisis or storm
0.000 0.925 0.075
E05.4 Thyrotoxicosis factitia
0.000 0.925 0.075
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.925 0.075
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.927 0.073
E21.4 Other specified disorders of parathyroid gland
0.000 0.929 0.071
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.929 0.071
E05.8 Other thyrotoxicosis
0.000 0.930 0.070
G35 Multiple sclerosis
0.000 0.932 0.068
E05.9 Thyrotoxicosis, unspecified
0.000 0.933 0.067
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.936 0.064
E07 Other disorders of thyroid
0.001 0.936 0.063
D86.0 Sarcoidosis of lung
0.000 0.937 0.063
D86 Sarcoidosis
0.000 0.937 0.063
D86.9 Sarcoidosis, unspecified
0.000 0.940 0.060
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.941 0.059
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.000 0.944 0.056
D86.1 Sarcoidosis of lymph nodes
0.000 0.944 0.056
D86.3 Sarcoidosis of skin
0.000 0.947 0.053
D86.8 Sarcoidosis of other and combined sites
0.000 0.953 0.047
E07.1 Dyshormogenetic goitre
0.001 0.954 0.045
E07.0 Hypersecretion of calcitonin
0.001 0.954 0.045
R29.2 Abnormal reflex
0.000 0.954 0.046
R29.0 Tetany
0.000 0.956 0.044
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.956 0.044
G62.9 Polyneuropathy, unspecified
0.000 0.956 0.044
E66 Obesity
0.000 0.957 0.043
E21.3 Hyperparathyroidism, unspecified
0.000 0.958 0.042
R29.1 Meningismus
0.000 0.959 0.041
R29.4 Clicking hip
0.000 0.959 0.041
R29.3 Abnormal posture
0.000 0.959 0.041
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.001 0.962 0.037
E03 Other hypothyroidism
0.014 0.963 0.023
E61.1 Iron deficiency
0.001 0.964 0.035
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.967 0.033
Z50.1 Other physical therapy
0.000 0.968 0.032
E14.9 Without complications
0.000 0.968 0.032
G62 Other polyneuropathies
0.000 0.968 0.032
M35 Other systemic involvement of connective tissue
0.000 0.968 0.032
M65.34 Trigger finger-Hand
0.000 0.969 0.031
E66.1 Drug-induced obesity
0.000 0.969 0.031
B18.2 Chronic viral hepatitis C
0.000 0.971 0.029
E66.0 Obesity due to excess calories
0.000 0.971 0.029
D80-D89 Certain disorders involving the immune mechanism
0.000 0.972 0.028
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.972 0.028
M79.65 Pain in limb (Pelvic region and thigh)
0.027 0.973 0.000
K37 Unspecified appendicitis
0.000 0.973 0.027
G62.0 Drug-induced polyneuropathy
0.000 0.973 0.027
E03.5 Myxoedema coma
0.010 0.973 0.017
E03.4 Atrophy of thyroid (acquired)
0.010 0.973 0.017
E03.3 Postinfectious hypothyroidism
0.010 0.973 0.017
M35.7 Hypermobility syndrome
0.000 0.974 0.026
E03.0 Congenital hypothyroidism with diffuse goitre
0.009 0.974 0.017
B18 Chronic viral hepatitis
0.000 0.974 0.026
E07.8 Other specified disorders of thyroid
0.002 0.974 0.024
E03.1 Congenital hypothyroidism without goitre
0.010 0.974 0.016
G36 Other acute disseminated demyelination
0.000 0.976 0.024
D82 Immunodeficiency associated with other major defects
0.000 0.976 0.024
M35.2 Behcet's disease
0.000 0.976 0.024
B18.1 Chronic viral hepatitis B without delta-agent
0.000 0.976 0.024
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.000 0.976 0.024
G62.2 Polyneuropathy due to other toxic agents
0.000 0.977 0.023
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.977 0.023
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.977 0.023
M35.5 Multifocal fibrosclerosis
0.000 0.977 0.023
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.977 0.023
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.012 0.977 0.011
D84 Other immunodeficiencies
0.000 0.978 0.022
E21.0 Primary hyperparathyroidism
0.000 0.979 0.021
C22.9 Liver, unspecified
0.021 0.979 0.000
D82.1 Di George's syndrome
0.000 0.979 0.021
M35.1 Other overlap syndromes
0.000 0.979 0.021
D81 Combined immunodeficiencies
0.000 0.979 0.021
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.000 0.979 0.021
G62.1 Alcoholic polyneuropathy
0.000 0.979 0.020
G62.8 Other specified polyneuropathies
0.000 0.980 0.020
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.980 0.020
M35.8 Other specified systemic involvement of connective tissue
0.000 0.980 0.020
E03.8 Other specified hypothyroidism
0.016 0.980 0.004
K90-K93 Other diseases of the digestive system
0.000 0.981 0.019
G63 Polyneuropathy in diseases classified elsewhere
0.000 0.981 0.019
B18.9 Chronic viral hepatitis, unspecified
0.000 0.981 0.019
B18.8 Other chronic viral hepatitis
0.000 0.981 0.019
B18.0 Chronic viral hepatitis B with delta-agent
0.000 0.981 0.019
G60 Hereditary and idiopathic neuropathy
0.000 0.981 0.019
D83 Common variable immunodeficiency
0.000 0.981 0.019
B15-B19 Viral hepatitis
0.000 0.981 0.019
G36.0 Neuromyelitis optica [Devic]
0.000 0.982 0.018
G36.9 Acute disseminated demyelination, unspecified
0.000 0.982 0.018
G36.8 Other specified acute disseminated demyelination
0.000 0.982 0.018
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.982 0.018
R26 Abnormalities of gait and mobility
0.000 0.982 0.018
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.982 0.017
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.982 0.017
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.982 0.017
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.982 0.017
D82.2 Immunodeficiency with short-limbed stature
0.000 0.982 0.017
D82.0 Wiskott-Aldrich syndrome
0.000 0.982 0.017
Chapter VI Diseases of the nervous system
0.000 0.983 0.017
G64 Other disorders of peripheral nervous system
0.000 0.983 0.017
E66.8 Other obesity
0.000 0.983 0.017
B16 Acute hepatitis B
0.000 0.983 0.017
G60.8 Other hereditary and idiopathic neuropathies
0.000 0.983 0.017
G37 Other demyelinating diseases of central nervous system
0.000 0.983 0.017
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified
0.000 0.983 0.017
D84.9 Immunodeficiency, unspecified
0.000 0.983 0.017
D84.8 Other specified immunodeficiencies
0.000 0.983 0.016
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.983 0.016
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.984 0.016
B16.9 Acute hepatitis B without delta-agent and without hepatic coma
0.000 0.984 0.016
B19 Unspecified viral hepatitis
0.000 0.984 0.016
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.984 0.016
D84.1 Defects in the complement system
0.000 0.984 0.016
G63.2 Diabetic polyneuropathy
0.000 0.984 0.016
D89.1 Cryoglobulinaemia
0.000 0.984 0.015
R26.8 Other and unspecified abnormalities of gait and mobility
0.000 0.985 0.015
D81.9 Combined immunodeficiency, unspecified
0.000 0.985 0.015
D81.8 Other combined immunodeficiencies
0.000 0.985 0.015
D81.7 Major histocompatibility complex class II deficiency
0.000 0.985 0.015
D81.6 Major histocompatibility complex class I deficiency
0.000 0.985 0.015
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.985 0.015
D81.4 Nezelof's syndrome
0.000 0.985 0.015
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.985 0.015
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.985 0.015
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.985 0.015
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.985 0.015
R26.0 Ataxic gait
0.000 0.985 0.015
D80 Immunodeficiency with predominantly antibody defects
0.000 0.985 0.015
D89.3 Immune reconstitution syndrome
0.000 0.985 0.015
G60.9 Hereditary and idiopathic neuropathy, unspecified
0.000 0.985 0.015
G30-G32 Other degenerative diseases of the nervous system
0.000 0.985 0.015
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.000 0.986 0.014
B19.9 Unspecified viral hepatitis without coma
0.000 0.986 0.014
B17 Other acute viral hepatitis
0.000 0.986 0.014
R26.2 Difficulty in walking, not elsewhere classified
0.000 0.986 0.014
E70-E90 Metabolic disorders
0.000 0.986 0.014
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.986 0.014
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.014 0.986 0.000
E07.9 Disorder of thyroid, unspecified
0.001 0.986 0.013
G63.8 Polyneuropathy in other diseases classified elsewhere
0.000 0.986 0.014
G63.6 Polyneuropathy in other musculoskeletal disorders
0.000 0.986 0.014
G63.5 Polyneuropathy in systemic connective tissue disorders
0.000 0.986 0.014
G63.4 Polyneuropathy in nutritional deficiency
0.000 0.986 0.014
G63.3 Polyneuropathy in other endocrine and metabolic diseases
0.000 0.986 0.014
G63.1 Polyneuropathy in neoplastic disease
0.000 0.986 0.014
G63.0 Polyneuropathy in infectious and parasitic diseases classified elsewhere
0.000 0.986 0.014
R27 Other lack of coordination
0.000 0.986 0.014
G60.3 Idiopathic progressive neuropathy
0.000 0.986 0.014
G60.2 Neuropathy in association with hereditary ataxia
0.000 0.986 0.014
G60.1 Refsum's disease
0.000 0.986 0.014
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.986 0.014
G56.0 Carpal tunnel syndrome
0.000 0.986 0.014
D83.8 Other common variable immunodeficiencies
0.000 0.986 0.013
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.986 0.013
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.986 0.013
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.986 0.013
G11 Hereditary ataxia
0.000 0.986 0.014
G11.9 Hereditary ataxia, unspecified
0.000 0.987 0.013
C22.0 Liver cell carcinoma
0.013 0.987 0.000
E03.9 Hypothyroidism, unspecified
0.013 0.987 0.000
R26.1 Paralytic gait
0.000 0.987 0.013
M65.3 Trigger finger
0.000 0.987 0.013
G30 Alzheimer's disease
0.000 0.987 0.013
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.987 0.013
B16.2 Acute hepatitis B without delta-agent with hepatic coma
0.000 0.987 0.012
B16.1 Acute hepatitis B with delta-agent (coinfection) without hepatic coma
0.000 0.987 0.012
B16.0 Acute hepatitis B with delta-agent (coinfection) with hepatic coma
0.000 0.987 0.012
G61 Inflammatory polyneuropathy
0.000 0.987 0.013
G37.5 Concentric sclerosis [Balo]
0.000 0.987 0.012
G37.4 Subacute necrotising myelitis
0.000 0.987 0.012
G37.2 Central pontine myelinolysis
0.000 0.987 0.012
G37.1 Central demyelination of corpus callosum
0.000 0.987 0.012
G37.0 Diffuse sclerosis
0.000 0.987 0.012
Z90.2 Acquired absence of lung [part of]
0.000 0.988 0.012
G00-G09 Inflammatory diseases of the central nervous system
0.000 0.988 0.012
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.988 0.012
B17.1 Acute hepatitis C
0.000 0.988 0.012
B19.0 Unspecified viral hepatitis with coma
0.000 0.988 0.012
E74 Other disorders of carbohydrate metabolism
0.000 0.988 0.012
D83.9 Common variable immunodeficiency, unspecified
0.000 0.988 0.011
G30.0 Alzheimer's disease with early onset
0.000 0.988 0.012
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.988 0.011
K12.1 Other forms of stomatitis
0.000 0.988 0.012
R27.0 Ataxia, unspecified
0.000 0.989 0.011
G30.9 Alzheimer's disease, unspecified
0.000 0.989 0.011
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.989 0.011
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.989 0.011
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.989 0.011
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.989 0.011
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.989 0.011
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.989 0.011
B15 Acute hepatitis A
0.000 0.989 0.011
G80-G83 Cerebral palsy and other paralytic syndromes
0.000 0.989 0.011
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.000 0.989 0.011
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.989 0.011
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.000 0.989 0.011
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.000 0.989 0.011
E70 Disorders of aromatic amino-acid metabolism
0.000 0.989 0.011
E80.6 Other disorders of bilirubin metabolism
0.000 0.989 0.011
E79 Disorders of purine and pyrimidine metabolism
0.000 0.989 0.011
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.000 0.989 0.010
B17.9 Acute viral hepatitis, unspecified
0.000 0.990 0.010
B17.2 Acute hepatitis E
0.000 0.990 0.010
B17.0 Acute delta-(super) infection of hepatitis B carrier
0.000 0.990 0.010
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.990 0.010
G10 Huntington's disease
0.000 0.990 0.010
E77 Disorders of glycoprotein metabolism
0.000 0.990 0.010
E76 Disorders of glycosaminoglycan metabolism
0.000 0.990 0.010
E72 Other disorders of amino-acid metabolism
0.000 0.990 0.010
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.990 0.010
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.990 0.010
C22.7 Other specified carcinomas of liver
0.010 0.990 0.000
C22.4 Other sarcomas of liver
0.010 0.990 0.000
C22.3 Angiosarcoma of liver
0.010 0.990 0.000
C22.2 Hepatoblastoma
0.010 0.990 0.000
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.990 0.010
K93.1 Megacolon in Chagas' disease
0.000 0.990 0.010
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.990 0.010
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.990 0.010
E73 Lactose intolerance
0.000 0.990 0.010
C18.6 Descending colon
0.010 0.990 0.000
C22.1 Intrahepatic bile duct carcinoma
0.010 0.990 0.000
G11.1 Early-onset cerebellar ataxia
0.000 0.990 0.010
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.990 0.010
G11.4 Hereditary spastic paraplegia
0.000 0.990 0.010
G11.8 Other hereditary ataxias
0.000 0.990 0.010
G11.3 Cerebellar ataxia with defective DNA repair
0.000 0.990 0.010
G11.2 Late-onset cerebellar ataxia
0.000 0.990 0.010
G11.0 Congenital nonprogressive ataxia
0.000 0.990 0.010
E80.2 Other porphyria
0.000 0.990 0.010
E84 Cystic fibrosis
0.000 0.990 0.010
G05.1 Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
0.000 0.990 0.010
G20-G26 Extrapyramidal and movement disorders
0.000 0.990 0.010
G24.9 Dystonia, unspecified
0.000 0.990 0.010
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.990 0.010
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.990 0.009

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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