TreeWAS – Variant ID: rs1049622

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	0.000	1.000
K90.0 Coeliac disease	0.000	0.000	1.000
L40.9 Psoriasis, unspecified	1.000	0.000	0.000
L40.5 Arthropathic psoriasis	1.000	0.000	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.000	1.000
L40 Psoriasis	1.000	0.000	0.000
E00-E07 Disorders of thyroid gland	0.000	0.000	1.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.000	1.000
E03 Other hypothyroidism	0.000	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	0.001	0.999
E10.9 Without complications	0.000	0.002	0.998
L40.0 Psoriasis vulgaris	0.996	0.004	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.004	0.996
E10-E14 Diabetes mellitus	0.000	0.015	0.985
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.015	0.985
E10.4 With neurological complications	0.000	0.042	0.958
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.051	0.949
M07.39 Other psoriatic arthropathies (Site unspecified)	0.939	0.061	0.000
M07.3 Other psoriatic arthropathies	0.938	0.062	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.934	0.066	0.000
E16 Other disorders of pancreatic internal secretion	0.000	0.077	0.923
E16.2 Hypoglycaemia, unspecified	0.000	0.095	0.905
E10.3 With ophthalmic complications	0.000	0.099	0.901
E10.5 With peripheral circulatory complications	0.000	0.109	0.891
L40.8 Other psoriasis	0.891	0.109	0.000
E07 Other disorders of thyroid	0.000	0.119	0.881
E10.1 With ketoacidosis	0.000	0.127	0.873
L40.1 Generalised pustular psoriasis	0.854	0.146	0.000
E10.6 With other specified complications	0.000	0.167	0.833
E07.9 Disorder of thyroid, unspecified	0.000	0.168	0.832
M07.34 Other psoriatic arthropathies (Hand)	0.824	0.176	0.000
E10.2 With renal complications	0.000	0.186	0.814
E10.0 With coma	0.000	0.189	0.811
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.198	0.802
M07.36 Other psoriatic arthropathies (Lower leg)	0.800	0.200	0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.780	0.220	0.000
E06 Thyroiditis	0.000	0.229	0.770
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.246	0.754
E50-E64 Other nutritional deficiencies	0.000	0.262	0.738
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.267	0.733
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.278	0.722
E05.8 Other thyrotoxicosis	0.000	0.283	0.717
E05.5 Thyroid crisis or storm	0.000	0.283	0.717
E05.4 Thyrotoxicosis factitia	0.000	0.283	0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.283	0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.283	0.717
L40.4 Guttate psoriasis	0.717	0.283	0.000
L40.3 Pustulosis palmaris et plantaris	0.717	0.283	0.000
L40.2 Acrodermatitis continua	0.717	0.283	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.283	0.717
E00 Congenital iodine-deficiency syndrome	0.000	0.283	0.717
E03.5 Myxoedema coma	0.000	0.283	0.717
E03.4 Atrophy of thyroid (acquired)	0.000	0.283	0.717
E03.3 Postinfectious hypothyroidism	0.000	0.283	0.717
E03.1 Congenital hypothyroidism without goitre	0.000	0.283	0.717
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.283	0.717
E10.7 With multiple complications	0.000	0.284	0.716
E12 Malnutrition-related diabetes mellitus	0.000	0.293	0.706
E15 Nondiabetic hypoglycaemic coma	0.000	0.320	0.680
M07.38 Other psoriatic arthropathies (Other)	0.673	0.327	0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.673	0.327	0.000
M07.33 Other psoriatic arthropathies (Forearm)	0.673	0.327	0.000
M07.32 Other psoriatic arthropathies (Upper arm)	0.673	0.327	0.000
M07.31 Other psoriatic arthropathies (Shoulder region)	0.673	0.327	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.338	0.661
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.338	0.661
E16.4 Abnormal secretion of gastrin	0.000	0.338	0.661
E16.3 Increased secretion of glucagon	0.000	0.338	0.661
E07.1 Dyshormogenetic goitre	0.000	0.368	0.632
E07.0 Hypersecretion of calcitonin	0.000	0.368	0.632
E03.8 Other specified hypothyroidism	0.000	0.397	0.603
E06.3 Autoimmune thyroiditis	0.000	0.399	0.601
E55 Vitamin D deficiency	0.000	0.419	0.581
E16.1 Other hypoglycaemia	0.000	0.432	0.567
E13 Other specified diabetes mellitus	0.000	0.439	0.561
E06.9 Thyroiditis, unspecified	0.000	0.441	0.559
E06.5 Other chronic thyroiditis	0.000	0.447	0.552
E06.4 Drug-induced thyroiditis	0.000	0.447	0.552
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.447	0.552
E06.1 Subacute thyroiditis	0.000	0.447	0.552
E06.0 Acute thyroiditis	0.000	0.447	0.552
E10.8 With unspecified complications	0.000	0.448	0.552
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.471	0.529
E63 Other nutritional deficiencies	0.000	0.471	0.529
E56 Other vitamin deficiencies	0.000	0.471	0.529
E51 Thiamine deficiency	0.000	0.471	0.529
E50 Vitamin A deficiency	0.000	0.471	0.529
E60 Dietary zinc deficiency	0.000	0.471	0.529
E59 Dietary selenium deficiency	0.000	0.471	0.529
E58 Dietary calcium deficiency	0.000	0.471	0.529
E54 Ascorbic acid deficiency	0.000	0.471	0.529
E52 Niacin deficiency [pellagra]	0.000	0.471	0.529
K90 Intestinal malabsorption	0.000	0.476	0.524
E53 Deficiency of other B group vitamins	0.000	0.477	0.523
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.486	0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.486	0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.486	0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.486	0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.486	0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.486	0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.486	0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.486	0.514
E61 Deficiency of other nutrient elements	0.000	0.489	0.511
E12.9 Without complications	0.000	0.493	0.506
E12.8 With unspecified complications	0.000	0.493	0.506
E12.7 With multiple complications	0.000	0.493	0.506
E12.6 With other specified complications	0.000	0.493	0.506
E12.5 With peripheral circulatory complications	0.000	0.493	0.506
E12.4 With neurological complications	0.000	0.493	0.506
E12.3 With ophthalmic complications	0.000	0.493	0.506
E12.2 With renal complications	0.000	0.493	0.506
E12.1 With ketoacidosis	0.000	0.493	0.506
E12.0 With coma	0.000	0.493	0.506
E65-E68 Obesity and other hyperalimentation	0.000	0.494	0.505
E40-E46 Malnutrition	0.001	0.510	0.489
E55.9 Vitamin D deficiency, unspecified	0.000	0.532	0.468
E04 Other non-toxic goitre	0.000	0.533	0.467
E14 Unspecified diabetes mellitus	0.000	0.535	0.465
E07.8 Other specified disorders of thyroid	0.000	0.554	0.445
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.560	0.440
E55.0 Rickets, active	0.000	0.583	0.416
K90.9 Intestinal malabsorption, unspecified	0.000	0.584	0.415
M07 Psoriatic and enteropathic arthropathies	0.410	0.590	0.000
E14.3 With ophthalmic complications	0.000	0.592	0.408
E13.8 With unspecified complications	0.000	0.598	0.402
E13.7 With multiple complications	0.000	0.598	0.402
E13.6 With other specified complications	0.000	0.598	0.402
E13.5 With peripheral circulatory complications	0.000	0.598	0.402
E13.4 With neurological complications	0.000	0.598	0.402
E13.3 With ophthalmic complications	0.000	0.598	0.402
E13.2 With renal complications	0.000	0.598	0.402
E13.1 With ketoacidosis	0.000	0.598	0.402
E13.0 With coma	0.000	0.598	0.402
E53.9 Vitamin B deficiency, unspecified	0.000	0.602	0.398
E50.9 Vitamin A deficiency, unspecified	0.000	0.620	0.380
E50.8 Other manifestations of vitamin A deficiency	0.000	0.620	0.380
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.620	0.380
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.620	0.380
E50.5 Vitamin A deficiency with night blindness	0.000	0.620	0.380
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.620	0.380
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.620	0.380
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.620	0.380
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.620	0.380
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.620	0.380
E51.9 Thiamine deficiency, unspecified	0.000	0.620	0.380
E51.8 Other manifestations of thiamine deficiency	0.000	0.620	0.380
E51.2 Wernicke's encephalopathy	0.000	0.620	0.380
E51.1 Beriberi	0.000	0.620	0.380
E56.9 Vitamin deficiency, unspecified	0.000	0.620	0.380
E56.8 Deficiency of other vitamins	0.000	0.620	0.380
E56.1 Deficiency of vitamin K	0.000	0.620	0.380
E56.0 Deficiency of vitamin E	0.000	0.620	0.380
E63.9 Nutritional deficiency, unspecified	0.000	0.620	0.380
E63.8 Other specified nutritional deficiencies	0.000	0.620	0.380
E63.1 Imbalance of constituents of food intake	0.000	0.620	0.380
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.620	0.380
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.620	0.380
E64.8 Sequelae of other nutritional deficiencies	0.000	0.620	0.380
E64.3 Sequelae of rickets	0.000	0.620	0.380
E64.2 Sequelae of vitamin C deficiency	0.000	0.620	0.380
E64.1 Sequelae of vitamin A deficiency	0.000	0.620	0.380
E64.0 Sequelae of protein-energy malnutrition	0.000	0.620	0.380
K90.3 Pancreatic steatorrhoea	0.000	0.624	0.376
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.624	0.376
K90.1 Tropical sprue	0.000	0.624	0.376
E53.1 Pyridoxine deficiency	0.000	0.625	0.375
E53.0 Riboflavin deficiency	0.000	0.625	0.375
E61.2 Magnesium deficiency	0.000	0.626	0.374
E04.9 Non-toxic goitre, unspecified	0.000	0.630	0.370
E61.9 Deficiency of nutrient element, unspecified	0.000	0.633	0.366
E61.8 Deficiency of other specified nutrient elements	0.000	0.633	0.366
E61.7 Deficiency of multiple nutrient elements	0.000	0.633	0.366
E61.6 Vanadium deficiency	0.000	0.633	0.366
E61.5 Molybdenum deficiency	0.000	0.633	0.366
E61.4 Chromium deficiency	0.000	0.633	0.366
E61.3 Manganese deficiency	0.000	0.633	0.366
E61.0 Copper deficiency	0.000	0.633	0.366
E67 Other hyperalimentation	0.000	0.637	0.362
E68 Sequelae of hyperalimentation	0.000	0.637	0.362
E44 Protein-energy malnutrition of moderate and mild degree	0.001	0.648	0.351
E45 Retarded development following protein-energy malnutrition	0.001	0.648	0.351
E43 Unspecified severe protein-energy malnutrition	0.001	0.648	0.351
E42 Marasmic kwashiorkor	0.001	0.648	0.351
E41 Nutritional marasmus	0.001	0.648	0.351
E40 Kwashiorkor	0.001	0.648	0.351
E61.1 Iron deficiency	0.000	0.660	0.340
E53.8 Deficiency of other specified B group vitamins	0.000	0.661	0.339
E04.8 Other specified non-toxic goitre	0.000	0.665	0.335
E14.7 With multiple complications	0.000	0.666	0.333
E14.6 With other specified complications	0.000	0.666	0.333
E14.2 Withrenal complications	0.000	0.666	0.333
E14.0 With coma	0.000	0.666	0.333
E14.1 With ketoacidosis	0.000	0.672	0.327
E14.8 With unspecified complications	0.000	0.681	0.319
E14.5 With peripheral circulatory complications	0.000	0.700	0.300
M07.6 Other enteropathic arthropathies	0.294	0.706	0.000
M07.5 Arthropathy in ulcerative colitis	0.294	0.706	0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.294	0.706	0.000
M07.2 Psoriatic spondylitis	0.294	0.706	0.000
M07.1 Arthritis mutilans	0.294	0.706	0.000
M07.0 Distal interphalangeal psoriatic arthropathy	0.294	0.706	0.000
E04.0 Non-toxic diffuse goitre	0.000	0.714	0.286
E65 Localised adiposity	0.000	0.716	0.284
E66 Obesity	0.000	0.717	0.283
E14.4 With neurological complications	0.000	0.730	0.269
E04.2 Non-toxic multinodular goitre	0.000	0.731	0.269
E66.8 Other obesity	0.000	0.738	0.262
E67.8 Other specified hyperalimentation	0.000	0.740	0.260
E67.3 Hypervitaminosis D	0.000	0.740	0.260
E67.2 Megavitamin-B6 syndrome	0.000	0.740	0.260
E67.1 Hypercarotenaemia	0.000	0.740	0.260
E67.0 Hypervitaminosis A	0.000	0.740	0.260
E13.9 Without complications	0.001	0.743	0.256
K90.8 Other intestinal malabsorption	0.001	0.744	0.255
E44.1 Mild protein-energy malnutrition	0.001	0.748	0.252
E44.0 Moderate protein-energy malnutrition	0.001	0.748	0.252
E20-E35 Disorders of other endocrine glands	0.000	0.773	0.227
L40-L45 Papulosquamous disorders	0.225	0.775	0.000
E04.1 Non-toxic single thyroid nodule	0.000	0.787	0.213
M07.09 Distal interphalangeal psoriatic arthropathy (Site unspecified)	0.211	0.789	0.000
M07.08 Distal interphalangeal proriatic arthropathy-Other	0.211	0.789	0.000
M07.07 Distal interphalangeal psoriatic arthropathy (Ankle and foot)	0.211	0.789	0.000
M07.06 Distal interphalangeal proriatic arthropathy-Lower leg	0.211	0.789	0.000
M07.05 Distal interphalangeal proriatic arthropathy-Pelvic/thigh	0.211	0.789	0.000
M07.04 Distal interphalangeal psoriatic arthropathy (Hand)	0.211	0.789	0.000
M07.03 Distal interphalangeal proriatic arthropathy-Forearm	0.211	0.789	0.000
M07.02 Distal interphalangeal proriatic arthropathy-Upper arm	0.211	0.789	0.000
M07.01 Distal interphalangeal proriatic arthropathy-Shldr region	0.211	0.789	0.000
M07.00 Distal interphalangeal psoriatic arthropathy (Multiple sites)	0.211	0.789	0.000
M07.19 Arthritis mutilans (Site unspecified)	0.211	0.789	0.000
M07.18 Arthritis mutilans (Other)	0.211	0.789	0.000
M07.17 Arthritis mutilans (Ankle and foot)	0.211	0.789	0.000
M07.16 Arthritis mutilans (Lower leg)	0.211	0.789	0.000
M07.15 Arthritis mutilans (Pelvic region and thigh)	0.211	0.789	0.000
M07.14 Arthritis mutilans (Hand)	0.211	0.789	0.000
M07.13 Arthritis mutilans (Forearm)	0.211	0.789	0.000
M07.12 Arthritis mutilans (Upper arm)	0.211	0.789	0.000
M07.11 Arthritis mutilans (Shoulder region)	0.211	0.789	0.000
M07.10 Arthritis mutilans (Multiple sites)	0.211	0.789	0.000
M07.29 Psoriatic spondylitis (Site unspecified)	0.211	0.789	0.000
M07.28 Psoriatic spondylitis (Other)	0.211	0.789	0.000
M07.27 Psoriatic spondylitis (Ankle and foot)	0.211	0.789	0.000
M07.26 Psoriatic spondylitis (Lower leg)	0.211	0.789	0.000
M07.25 Psoriatic spondylitis (Pelvic region and thigh)	0.211	0.789	0.000
M07.24 Psoriatic spondylitis (Hand)	0.211	0.789	0.000
M07.23 Psoriatic spondylitis (Forearm)	0.211	0.789	0.000
M07.22 Psoriatic spondylitis (Upper arm)	0.211	0.789	0.000
M07.21 Psoriatic spondylitis (Shoulder region)	0.211	0.789	0.000
M07.20 Psoriatic spondylitis (Multiple sites)	0.211	0.789	0.000
M07.49 Arthropathy in Crohn's disease [regional enteritis] (Site unspecified)	0.211	0.789	0.000
M07.48 Arthropathy in Crohn's disease [regional enteritis] (Other)	0.211	0.789	0.000
M07.47 Arthropathy in Crohn's disease [regional enteritis] (Ankle and foot)	0.211	0.789	0.000
M07.46 Arthropathy in Crohn's disease [regional enteritis] (Lower leg)	0.211	0.789	0.000
M07.45 Arthropathy in Crohn's disease [regional enteritis] (Pelvic region and thigh)	0.211	0.789	0.000
M07.44 Arthropathy in Crohn's disease [regional enteritis] (Hand)	0.211	0.789	0.000
M07.43 Arthropathy in Crohn's disease [regional enteritis] (Forearm)	0.211	0.789	0.000
M07.42 Arthropathy in Crohn's disease [regional enteritis] (Upper arm)	0.211	0.789	0.000
M07.41 Arthropathy in Crohn's disease [regional enteritis] (Shoulder region)	0.211	0.789	0.000
M07.40 Arthropathy in Crohn's disease [regional enteritis] (Multiple sites)	0.211	0.789	0.000
M07.59 Arthropathy in ulcerative colitis (Site unspecified)	0.211	0.789	0.000
M07.58 Arthropathy in ulcerative colitis (Other)	0.211	0.789	0.000
M07.57 Arthropathy in ulcerative colitis (Ankle and foot)	0.211	0.789	0.000
M07.56 Arthropathy in ulcerative colitis (Lower leg)	0.211	0.789	0.000
M07.55 Arthropathy in ulcerative colitis (Pelvic region and thigh)	0.211	0.789	0.000
M07.54 Arthropathy in ulcerative colitis (Hand)	0.211	0.789	0.000
M07.53 Arthropathy in ulcerative colitis (Forearm)	0.211	0.789	0.000
M07.52 Arthropathy in ulcerative colitis (Upper arm)	0.211	0.789	0.000
M07.51 Arthropathy in ulcerative colitis (Shoulder region)	0.211	0.789	0.000
M07.50 Arthropathy in ulcerative colitis (Multiple sites)	0.211	0.789	0.000
M07.69 Other enteropathic arthropathies (Site unspecified)	0.211	0.789	0.000
M07.68 Other enteropathic arthropathies (Other)	0.211	0.789	0.000
M07.67 Other enteropathic arthropathies (Ankle and foot)	0.211	0.789	0.000
M07.66 Other enteropathic arthropathies (Lower leg)	0.211	0.789	0.000
M07.65 Other enteropathic arthropathies (Pelvic region and thigh)	0.211	0.789	0.000
M07.64 Other enteropathic arthropathies (Hand)	0.211	0.789	0.000
M07.63 Other enteropathic arthropathies (Forearm)	0.211	0.789	0.000
M07.62 Other enteropathic arthropathies (Upper arm)	0.211	0.789	0.000
M07.61 Other enteropathic arthropathies (Shoulder region)	0.211	0.789	0.000
M07.60 Other enteropathic arthropathies (Multiple sites)	0.211	0.789	0.000
E27 Other disorders of adrenal gland	0.000	0.796	0.204
E66.1 Drug-induced obesity	0.000	0.797	0.203
E27.1 Primary adrenocortical insufficiency	0.000	0.798	0.202
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.824	0.176
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.837	0.163
E32 Diseases of thymus	0.000	0.837	0.163
E31 Polyglandular dysfunction	0.000	0.837	0.163
E30 Disorders of puberty, not elsewhere classified	0.000	0.837	0.163
E25 Adrenogenital disorders	0.000	0.837	0.163
L44 Other papulosquamous disorders	0.161	0.838	0.000
L41 Parapsoriasis	0.161	0.838	0.000
L45 Papulosquamous disorders in diseases classified elsewhere	0.161	0.838	0.000
L42 Pityriasis rosea	0.156	0.843	0.000
E34 Other endocrine disorders	0.000	0.845	0.155
E29 Testicular dysfunction	0.000	0.846	0.154
E20 Hypoparathyroidism	0.000	0.846	0.154
E27.8 Other specified disorders of adrenal gland	0.000	0.847	0.152
E66.0 Obesity due to excess calories	0.000	0.849	0.150
E27.5 Adrenomedullary hyperfunction	0.000	0.853	0.147
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.853	0.147
E27.0 Other adrenocortical overactivity	0.000	0.853	0.147
E22 Hyperfunction of pituitary gland	0.000	0.858	0.141
E26 Hyperaldosteronism	0.000	0.859	0.141
E24 Cushing's syndrome	0.000	0.860	0.139
E27.2 Addisonian crisis	0.000	0.863	0.137
E46 Unspecified protein-energy malnutrition	0.002	0.864	0.134
E28 Ovarian dysfunction	0.000	0.865	0.135
E34.9 Endocrine disorder, unspecified	0.000	0.882	0.118
E25.9 Adrenogenital disorder, unspecified	0.000	0.883	0.117
E25.8 Other adrenogenital disorders	0.000	0.883	0.117
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.000	0.883	0.117
E30.9 Disorder of puberty, unspecified	0.000	0.883	0.117
E30.8 Other disorders of puberty	0.000	0.883	0.117
E30.1 Precocious puberty	0.000	0.883	0.117
E30.0 Delayed puberty	0.000	0.883	0.117
E31.9 Polyglandular dysfunction, unspecified	0.000	0.883	0.117
E31.8 Other polyglandular dysfunction	0.000	0.883	0.117
E31.1 Polyglandular hyperfunction	0.000	0.883	0.117
E31.0 Autoimmune polyglandular failure	0.000	0.883	0.117
E32.9 Disease of thymus, unspecified	0.000	0.883	0.117
E32.8 Other diseases of thymus	0.000	0.883	0.117
E32.1 Abscess of thymus	0.000	0.883	0.117
E32.0 Persistent hyperplasia of thymus	0.000	0.883	0.117
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.883	0.117
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.883	0.117
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.883	0.117
E34.0 Carcinoid syndrome	0.000	0.884	0.116
L41.9 Parapsoriasis, unspecified	0.116	0.884	0.000
L41.8 Other parapsoriasis	0.116	0.884	0.000
L41.5 Retiform parapsoriasis	0.116	0.884	0.000
L41.4 Large plaque parapsoriasis	0.116	0.884	0.000
L41.3 Small plaque parapsoriasis	0.116	0.884	0.000
L41.2 Lymphomatoid papulosis	0.116	0.884	0.000
L41.1 Pityriasis lichenoides chronica	0.116	0.884	0.000
L41.0 Pityriasis lichenoides et varioliformis acuta	0.116	0.884	0.000
L44.9 Papulosquamous disorder, unspecified	0.116	0.884	0.000
L44.8 Other specified papulosquamous disorders	0.116	0.884	0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]	0.116	0.884	0.000
L44.3 Lichen ruber moniliformis	0.116	0.884	0.000
L44.2 Lichen striatus	0.116	0.884	0.000
L44.1 Lichen nitidus	0.116	0.884	0.000
L44.0 Pityriasis rubra pilaris	0.116	0.884	0.000
E22.1 Hyperprolactinaemia	0.000	0.888	0.112
E34.5 Androgen resistance syndrome	0.000	0.889	0.111
E34.4 Constitutional tall stature	0.000	0.889	0.111
E34.3 Short stature, not elsewhere classified	0.000	0.889	0.111
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.889	0.111
E34.1 Other hypersecretion of intestinal hormones	0.000	0.889	0.111
E29.9 Testicular dysfunction, unspecified	0.000	0.889	0.111
E29.8 Other testicular dysfunction	0.000	0.889	0.111
E29.0 Testicular hyperfunction	0.000	0.889	0.111
E20.8 Other hypoparathyroidism	0.000	0.889	0.110
E20.1 Pseudohypoparathyroidism	0.000	0.889	0.110
E20.0 Idiopathic hypoparathyroidism	0.000	0.889	0.110
E29.1 Testicular hypofunction	0.000	0.898	0.102
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.898	0.102
E22.8 Other hyperfunction of pituitary gland	0.000	0.898	0.102
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.898	0.101
E20.9 Hypoparathyroidism, unspecified	0.000	0.899	0.101
E24.2 Drug-induced Cushing's syndrome	0.000	0.899	0.101
E26.9 Hyperaldosteronism, unspecified	0.000	0.899	0.101
E26.8 Other hyperaldosteronism	0.000	0.899	0.101
E26.1 Secondary hyperaldosteronism	0.000	0.899	0.101
E24.8 Other Cushing's syndrome	0.000	0.900	0.100
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.900	0.100
E24.3 Ectopic ACTH syndrome	0.000	0.900	0.100
E24.1 Nelson's syndrome	0.000	0.900	0.100
L98.9 Disorder of skin and subcutaneous tissue, unspecified	0.000	0.900	0.100
E28.9 Ovarian dysfunction, unspecified	0.000	0.903	0.097
E28.8 Other ovarian dysfunction	0.000	0.903	0.097
E28.1 Androgen excess	0.000	0.903	0.097
E28.0 Oestrogen excess	0.000	0.903	0.097
E22.0 Acromegaly and pituitary gigantism	0.000	0.905	0.095
E28.3 Primary ovarian failure	0.000	0.906	0.094
E27.9 Disorder of adrenal gland, unspecified	0.001	0.909	0.091
E24.0 Pituitary-dependent Cushing's disease	0.000	0.910	0.090
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.910	0.090
E23 Hypofunction and other disorders of pituitary gland	0.000	0.911	0.089
E24.9 Cushing's syndrome, unspecified	0.000	0.912	0.088
E34.8 Other specified endocrine disorders	0.000	0.913	0.086
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.084	0.916	0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.082	0.918	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.081	0.919	0.000
L43 Lichen planus	0.079	0.920	0.001
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.079	0.921	0.000
E26.0 Primary hyperaldosteronism	0.000	0.921	0.078
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.078	0.922	0.000
E28.2 Polycystic ovarian syndrome	0.000	0.927	0.073
T43.2 Other and unspecified antidepressants	0.072	0.928	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.071	0.929	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.000	0.930	0.070
K90-K93 Other diseases of the digestive system	0.000	0.931	0.069
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.068	0.932	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.068	0.932	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.068	0.932	0.000
E14.9 Without complications	0.000	0.932	0.068
T43.0 Tricyclic and tetracyclic antidepressants	0.067	0.933	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.066	0.934	0.000
E21.4 Other specified disorders of parathyroid gland	0.000	0.935	0.064
E21.2 Other hyperparathyroidism	0.000	0.935	0.064
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.064	0.935	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.000	0.936	0.064
E23.1 Drug-induced hypopituitarism	0.000	0.936	0.064
T43.6 Psychostimulants with abuse potential	0.064	0.936	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.063	0.936	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.062	0.938	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.062	0.938	0.000
T36 Poisoning by systemic antibiotics	0.061	0.939	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.061	0.939	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.061	0.939	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.061	0.939	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.061	0.939	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.061	0.939	0.000
T44.0 Anticholinesterase agents	0.061	0.939	0.000
E21.0 Primary hyperparathyroidism	0.000	0.939	0.061
E23.0 Hypopituitarism	0.000	0.940	0.060
T50.9 Other and unspecified drugs, medicaments and biological substances	0.060	0.940	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.058	0.942	0.000
Chapter V Mental and behavioural disorders	0.058	0.942	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.058	0.942	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.058	0.942	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.058	0.942	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.058	0.942	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.058	0.942	0.000
F33 Recurrent depressive disorder	0.058	0.942	0.000
L43.3 Subacute (active) lichen planus	0.057	0.942	0.001
L43.2 Lichenoid drug reaction	0.057	0.942	0.001
L43.1 Bullous lichen planus	0.057	0.942	0.001
L43.0 Hypertrophic lichen planus	0.057	0.942	0.001
E21.3 Hyperparathyroidism, unspecified	0.000	0.943	0.057
T43.9 Psychotropic drug, unspecified	0.057	0.943	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.057	0.943	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.057	0.943	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.057	0.943	0.000
F30-F39 Mood [affective] disorders	0.056	0.944	0.000
E23.2 Diabetes insipidus	0.000	0.944	0.056
F33.9 Recurrent depressive disorder, unspecified	0.056	0.944	0.000
T47.4 Other laxatives	0.056	0.944	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.055	0.945	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.055	0.945	0.000
F60-F69 Disorders of adult personality and behaviour	0.054	0.946	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.054	0.946	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.053	0.947	0.000
F60 Specific personality disorders	0.053	0.947	0.000
F40 Phobic anxiety disorders	0.053	0.947	0.000
E23.6 Other disorders of pituitary gland	0.000	0.948	0.052
M35.0 Sicca syndrome [Sjogren]	0.000	0.949	0.051
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.051	0.949	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.051	0.949	0.000
T47.7 Emetics	0.051	0.949	0.000
T47.6 Antidiarrhoeal drugs	0.051	0.949	0.000
T47.5 Digestants	0.051	0.949	0.000
T47.3 Saline and osmotic laxatives	0.051	0.949	0.000
T47.2 Stimulant laxatives	0.051	0.949	0.000
T47.0 Histamine H(2)-receptor antagonists	0.051	0.949	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.051	0.949	0.000
F52 Sexual dysfunction, not caused by organic disorder or disease	0.050	0.950	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.950	0.050
F40.2 Specific (isolated) phobias	0.050	0.950	0.000
F33.1 Recurrent depressive disorder, current episode moderate	0.050	0.950	0.000
K93 Disorders of other digestive organs in diseases classified elsewhere	0.000	0.950	0.050
F60.3 Emotionally unstable personality disorder	0.050	0.950	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.050	0.950	0.000
T50.8 Diagnostic agents	0.049	0.951	0.000
T50.7 Analeptics and opioid receptor antagonists	0.049	0.951	0.000
T50.6 Antidotes and chelating agents, not elsewhere classified	0.049	0.951	0.000
T50.5 Appetite depressants	0.049	0.951	0.000
T50.4 Drugs affecting uric acid metabolism	0.049	0.951	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.049	0.951	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.049	0.951	0.000
T50.1 Loop [high-ceiling] diuretics	0.049	0.951	0.000
T50.0 Mineralocorticoids and their antagonists	0.049	0.951	0.000
F48 Other neurotic disorders	0.048	0.952	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.048	0.952	0.000
F52.2 Failure of genital response	0.048	0.952	0.000
T45.0 Antiallergic and antiemetic drugs	0.048	0.952	0.000
T38.1 Thyroid hormones and substitutes	0.048	0.952	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.048	0.952	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.048	0.952	0.000
T42.3 Barbiturates	0.048	0.952	0.000
T42.2 Succinimides and oxazolidinediones	0.048	0.952	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.952	0.047
T36.0 Penicillins	0.047	0.953	0.000
T46.5 Other antihypertensive drugs, not elsewhere classified	0.047	0.953	0.000
R41.0 Disorientation, unspecified	0.000	0.953	0.047
F34 Persistent mood [affective] disorders	0.047	0.953	0.000
T42.0 Hydantoin derivatives	0.046	0.954	0.000
L43.8 Other lichen planus	0.045	0.954	0.001
F25 Schizoaffective disorders	0.046	0.954	0.000
E23.7 Disorder of pituitary gland, unspecified	0.001	0.954	0.046
F44 Dissociative [conversion] disorders	0.046	0.954	0.000
T38.9 Other and unspecified hormone antagonists	0.046	0.954	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.046	0.954	0.000
T38.7 Androgens and anabolic congeners	0.046	0.954	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.046	0.954	0.000
T38.5 Other oestrogens and progestogens	0.046	0.954	0.000
T38.4 Oral contraceptives	0.046	0.954	0.000
T38.2 Antithyroid drugs	0.046	0.954	0.000
T38.0 Glucocorticoids and synthetic analogues	0.046	0.954	0.000
F20 Schizophrenia	0.046	0.954	0.000
T45.1 Antineoplastic and immunosuppressive drugs	0.046	0.954	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations