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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs117216419
log Bayes Factor = 13.1076
Chromosome 19   position 41,700,346  (GRCh37) Explore rs117216419 on Ensembl!
Variant rs117216419 is part of Cluster X0320

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
0.999 0.001 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.999 0.001 0.000
M15-M19 Arthrosis
0.997 0.003 0.000
M20 Acquired deformities of fingers and toes
0.995 0.005 0.000
Chapter VI Diseases of the nervous system
0.993 0.007 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.992 0.008 0.000
M05-M14 Inflammatory polyarthropathies
0.989 0.011 0.000
Chapter II Neoplasms
0.988 0.012 0.000
Chapter V Mental and behavioural disorders
0.987 0.013 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.983 0.017 0.000
M16 Coxarthrosis [arthrosis of hip]
0.975 0.025 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.972 0.028 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.966 0.034 0.000
F30-F39 Mood [affective] disorders
0.964 0.036 0.000
M06 Other rheumatoid arthritis
0.962 0.038 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.961 0.039 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.961 0.039 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.954 0.046 0.000
M20.1 Hallux valgus (acquired)
0.948 0.052 0.000
G30-G32 Other degenerative diseases of the nervous system
0.941 0.059 0.000
M20.4 Other hammer toe(s) (acquired)
0.939 0.061 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.936 0.064 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.935 0.065 0.000
M06.9 Rheumatoid arthritis, unspecified
0.930 0.070 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.929 0.071 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.921 0.079 0.000
M25 Other joint disorders, not elsewhere classified
0.920 0.080 0.000
M65-M68 Disorders of synovium and tendon
0.918 0.082 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.918 0.082 0.000
M16.9 Coxarthrosis, unspecified
0.913 0.087 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.910 0.090 0.000
M17 Gonarthrosis [arthrosis of knee]
0.909 0.091 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.909 0.091 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.908 0.092 0.000
D60-D64 Aplastic and other anaemias
0.902 0.098 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.897 0.103 0.000
M19 Other arthrosis
0.894 0.106 0.000
M20.5 Other deformities of toe(s) (acquired)
0.892 0.108 0.000
C64-C68 Malignant neoplasms of urinary tract
0.891 0.109 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.891 0.109 0.000
Y43 Primarily systemic agents
0.890 0.110 0.000
M23 Internal derangement of knee
0.886 0.114 0.000
E10-E14 Diabetes mellitus
0.882 0.118 0.000
E20-E35 Disorders of other endocrine glands
0.882 0.118 0.000
M10 Gout
0.879 0.121 0.000
M45-M49 Spondylopathies
0.875 0.125 0.000
E50-E64 Other nutritional deficiencies
0.875 0.125 0.000
E70-E90 Metabolic disorders
0.871 0.129 0.000
T66-T78 Other and unspecified effects of external causes
0.868 0.132 0.000
F32 Depressive episode
0.865 0.135 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.862 0.138 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.862 0.138 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.861 0.139 0.000
M86-M90 Other osteopathies
0.859 0.141 0.000
Chapter I Certain infectious and parasitic diseases
0.859 0.141 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.858 0.142 0.000
M24 Other specific joint derangements
0.858 0.142 0.000
F33 Recurrent depressive disorder
0.858 0.142 0.000
Chapter VII Diseases of the eye and adnexa
0.854 0.146 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.851 0.149 0.000
E00-E07 Disorders of thyroid gland
0.850 0.150 0.000
M19.0 Primary arthrosis of other joints
0.850 0.150 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.848 0.152 0.000
F31 Bipolar affective disorder
0.847 0.153 0.000
W00-W19 Falls
0.846 0.154 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.844 0.156 0.000
M65 Synovitis and tenosynovitis
0.844 0.156 0.000
M16.1 Other primary coxarthrosis
0.843 0.157 0.000
M21 Other acquired deformities of limbs
0.840 0.160 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.839 0.161 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.838 0.162 0.000
B95-B98 Bacterial, viral and other infectious agents
0.837 0.163 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.836 0.164 0.000
M20.2 Hallux rigidus
0.836 0.164 0.000
Y43.3 Other antineoplastic drugs
0.835 0.165 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.829 0.170 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.829 0.171 0.000
T93 Sequelae of injuries of lower limb
0.828 0.172 0.000
F60-F69 Disorders of adult personality and behaviour
0.819 0.180 0.000
M25.8 Other specified joint disorders
0.819 0.181 0.000
Y83.0 Surgical operation with transplant of whole organ
0.819 0.181 0.000
C80 Malignant neoplasm without specification of site
0.817 0.183 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.817 0.183 0.000
M25.7 Osteophyte
0.817 0.183 0.000
Y86 Sequelae of other accidents
0.815 0.185 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.814 0.186 0.000
G90-G99 Other disorders of the nervous system
0.812 0.188 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.812 0.188 0.000
S40-S49 Injuries to the shoulder and upper arm
0.807 0.193 0.000
M16.0 Primary coxarthrosis, bilateral
0.807 0.193 0.000
E04 Other non-toxic goitre
0.807 0.193 0.000
Y44 Agents primarily affecting blood constituents
0.805 0.195 0.000
X60-X84 Intentional self-harm
0.804 0.195 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.804 0.196 0.000
M10.9 Gout, unspecified
0.800 0.200 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.799 0.201 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.798 0.201 0.000
D80-D89 Certain disorders involving the immune mechanism
0.798 0.202 0.000
G20-G26 Extrapyramidal and movement disorders
0.797 0.203 0.000
M48 Other spondylopathies
0.796 0.204 0.000
E11 Non-insulin-dependent diabetes mellitus
0.795 0.205 0.000
M40-M43 Deforming dorsopathies
0.794 0.206 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.790 0.210 0.000
C67 Malignant neoplasm of bladder
0.788 0.212 0.000
T90 Sequelae of injuries of head
0.786 0.214 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.785 0.214 0.000
M06.3 Rheumatoid nodule
0.784 0.216 0.000
D63.0 Anaemia in neoplastic disease
0.783 0.217 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.783 0.217 0.000
F03 Unspecified dementia
0.782 0.218 0.000
D64 Other anaemias
0.777 0.223 0.000
C60-C63 Malignant neoplasms of male genital organs
0.777 0.223 0.000
C51-C58 Malignant neoplasms of female genital organs
0.776 0.224 0.000
G40-G47 Episodic and paroxysmal disorders
0.776 0.224 0.000
M17.0 Primary gonarthrosis, bilateral
0.775 0.225 0.000
S20-S29 Injuries to the thorax
0.774 0.226 0.000
D50-D53 Nutritional anaemias
0.774 0.226 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.773 0.227 0.000
E86 Volume depletion
0.772 0.228 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.770 0.230 0.000
C15-C26 Malignant neoplasms of digestive organs
0.770 0.230 0.000
Q50-Q56 Congenital malformations of genital organs
0.770 0.230 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.765 0.234 0.000
T43.2 Other and unspecified antidepressants
0.764 0.236 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.763 0.237 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.762 0.238 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.762 0.238 0.000
M13 Other arthritis
0.761 0.239 0.000
M16.3 Other dysplastic coxarthrosis
0.761 0.239 0.000
Y52 Agents primarily affecting the cardiovascular system
0.760 0.240 0.000
C83.3 Large cell (diffuse)
0.759 0.241 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.758 0.242 0.000
M05 Seropositive rheumatoid arthritis
0.758 0.242 0.000
C81 Hodgkin's disease
0.757 0.243 0.000
S90-S99 Injuries to the ankle and foot
0.757 0.243 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.757 0.243 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.756 0.244 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.756 0.244 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.756 0.244 0.000
C80.9 Malignant neoplasm, unspecified
0.755 0.245 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.755 0.245 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.754 0.246 0.000
E14 Unspecified diabetes mellitus
0.753 0.247 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.752 0.248 0.000
H40-H42 Glaucoma
0.751 0.249 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.751 0.249 0.000
X50-X57 Overexertion, travel and privation
0.749 0.251 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.749 0.251 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.748 0.252 0.000
T79-T79 Certain early complications of trauma
0.748 0.252 0.000
G30 Alzheimer's disease
0.744 0.256 0.000
S70-S79 Injuries to the hip and thigh
0.742 0.258 0.000
M11 Other crystal arthropathies
0.741 0.258 0.000
E04.2 Non-toxic multinodular goitre
0.741 0.259 0.000
M19.04 Primary arthrosis of other joints (Hand)
0.740 0.260 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.740 0.260 0.000
E28 Ovarian dysfunction
0.740 0.260 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.740 0.260 0.000
E11.3 With ophthalmic complications
0.739 0.261 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.739 0.261 0.000
T86 Failure and rejection of transplanted organs and tissues
0.739 0.261 0.000
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)
0.737 0.263 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.736 0.264 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.736 0.264 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.736 0.264 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.735 0.265 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.734 0.266 0.000
F32.1 Moderate depressive episode
0.734 0.266 0.000
S10-S19 Injuries to the neck
0.733 0.267 0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)
0.733 0.267 0.000
M17.3 Other posttraumatic gonarthrosis
0.733 0.267 0.000
M17.9 Gonarthrosis, unspecified
0.732 0.268 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.732 0.268 0.000
T78 Adverse effects, not elsewhere classified
0.732 0.268 0.000
F32.2 Severe depressive episode without psychotic symptoms
0.732 0.268 0.000
V80-V89 Other land transport accidents
0.731 0.269 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.730 0.270 0.000
F80-F89 Disorders of psychological development
0.730 0.270 0.000
M10.99 Gout, unspecified (Site unspecified)
0.729 0.271 0.000
M91-M94 Chondropathies
0.728 0.272 0.000
M31 Other necrotising vasculopathies
0.728 0.272 0.000
Chapter XXII Codes for special purposes
0.725 0.275 0.000
C85.1 B-cell lymphoma, unspecified
0.725 0.275 0.000
T40.2 Other opioids
0.725 0.275 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.724 0.276 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.724 0.276 0.000
V20-V29 Motorcycle rider injured in transport accident
0.723 0.276 0.000
M48.0 Spinal stenosis
0.723 0.277 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.721 0.279 0.000
F00 Dementia in Alzheimer's disease
0.719 0.281 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.719 0.281 0.000
G81 Hemiplegia
0.719 0.281 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.718 0.282 0.000
Y85 Sequelae of transport accidents
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
M34 Systemic sclerosis
0.717 0.283 0.000
M33 Dermatopolymyositis
0.717 0.283 0.000
M32 Systemic lupus erythematosus
0.717 0.283 0.000
M30 Polyarteritis nodosa and related conditions
0.717 0.283 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.716 0.284 0.000
Y35-Y36 Legal intervention and operations of war
0.716 0.284 0.000
Y10-Y34 Event of undetermined intent
0.716 0.284 0.000
Y00-Y09 Assault
0.716 0.284 0.000
X85-X99 Assault
0.716 0.284 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.716 0.284 0.000
X30-X39 Exposure to forces of nature
0.716 0.284 0.000
X20-X29 Contact with venomous animals and plants
0.716 0.284 0.000
X10-X19 Contact with heat and hot substances
0.716 0.284 0.000
X00-X09 Exposure to smoke, fire and flames
0.716 0.284 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.716 0.284 0.000
W75-W84 Other accidental threats to breathing
0.716 0.284 0.000
W65-W74 Accidental drowning and submersion
0.716 0.284 0.000
W50-W64 Exposure to animate mechanical forces
0.716 0.284 0.000
V98-V99 Other and unspecified transport accidents
0.716 0.284 0.000
V95-V97 Air and space transport accidents
0.716 0.284 0.000
V90-V94 Water transport accidents
0.716 0.284 0.000
V70-V79 Bus occupant injured in transport accident
0.716 0.284 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.716 0.284 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.716 0.284 0.000
V40-V49 Car occupant injured in transport accident
0.716 0.284 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.716 0.284 0.000
V01-V09 Pedestrian injured in transport accident
0.716 0.284 0.000
T33-T35 Frostbite
0.716 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.284 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.716 0.284 0.000
T00-T07 Injuries involving multiple body regions
0.716 0.284 0.000
M15 Polyarthrosis
0.714 0.285 0.000
Q60-Q64 Congenital malformations of the urinary system
0.714 0.286 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.713 0.287 0.000
M67 Other disorders of synovium and tendon
0.713 0.287 0.000
E55 Vitamin D deficiency
0.713 0.287 0.000
M25.4 Effusion of joint
0.712 0.288 0.000
G70-G73 Diseases of myoneural junction and muscle
0.712 0.288 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.712 0.288 0.000
E40-E46 Malnutrition
0.711 0.289 0.000
M89 Other disorders of bone
0.711 0.289 0.000
M14 Arthropathies in other diseases classified elsewhere
0.709 0.290 0.000
M12 Other specific arthropathies
0.709 0.290 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.709 0.290 0.000
M08 Juvenile arthritis
0.709 0.290 0.000
E53 Deficiency of other B group vitamins
0.709 0.291 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.708 0.292 0.000
E04.9 Non-toxic goitre, unspecified
0.708 0.292 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.707 0.293 0.000
F70-F79 Mental retardation
0.707 0.293 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.707 0.293 0.000
T93.2 Sequelae of other fractures of lower limb
0.706 0.294 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.705 0.295 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.705 0.295 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.705 0.295 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.705 0.295 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.705 0.295 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.705 0.295 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.705 0.295 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.705 0.295 0.000
T36 Poisoning by systemic antibiotics
0.705 0.295 0.000
D55-D59 Haemolytic anaemias
0.705 0.295 0.000
T80.8 Other complications following infusion, transfusion and therapeutic injection
0.704 0.296 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.703 0.297 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.703 0.297 0.000
C91 Lymphoid leukaemia
0.703 0.297 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.703 0.297 0.000
E80.4 Gilbert's syndrome
0.703 0.297 0.000
M19.01 Primary arthrosis of other joints (Shoulder region)
0.702 0.297 0.000
T80.2 Infections following infusion, transfusion and therapeutic injection
0.701 0.299 0.000
M18 Arthrosis of first carpometacarpal joint
0.701 0.299 0.000
F99-F99 Unspecified mental disorder
0.701 0.299 0.000
M25.86 Other specified joint disorders (Lower leg)
0.700 0.300 0.000
T75 Effects of other external causes
0.700 0.300 0.000
G95 Other diseases of spinal cord
0.700 0.300 0.000
F60 Specific personality disorders
0.700 0.300 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.699 0.300 0.000
M16.6 Other secondary coxarthrosis, bilateral
0.699 0.301 0.000
M16.5 Other posttraumatic coxarthrosis
0.699 0.301 0.000
M16.4 Posttraumatic coxarthrosis, bilateral
0.699 0.301 0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral
0.699 0.301 0.000
M80-M85 Disorders of bone density and structure
0.699 0.301 0.000
M06.0 Seronegative rheumatoid arthritis
0.698 0.302 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.698 0.302 0.000
F33.9 Recurrent depressive disorder, unspecified
0.697 0.303 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.697 0.303 0.000
T87 Complications peculiar to reattachment and amputation
0.697 0.303 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.697 0.303 0.000
T40.6 Other and unspecified narcotics
0.696 0.304 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.696 0.304 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.695 0.304 0.000
M20.3 Other deformity of hallux (acquired)
0.695 0.305 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.695 0.305 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.694 0.306 0.000
E11.4 With neurological complications
0.694 0.306 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.693 0.307 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.693 0.307 0.000
Y59 Other and unspecified vaccines and biological substances
0.693 0.307 0.000
Y58 Bacterial vaccines
0.693 0.307 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.693 0.307 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.693 0.307 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.693 0.307 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.693 0.307 0.000
Y48 Anaesthetics and therapeutic gases
0.693 0.307 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.693 0.307 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.693 0.307 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.693 0.307 0.000
Y57 Other and unspecified drugs and medicaments
0.692 0.307 0.000
W20-W49 Exposure to inanimate mechanical forces
0.692 0.308 0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.692 0.308 0.000
F38 Other mood [affective] disorders
0.691 0.309 0.000
F34 Persistent mood [affective] disorders
0.691 0.309 0.000
F30 Manic episode
0.691 0.309 0.000
F39 Unspecified mood [affective] disorder
0.691 0.309 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.690 0.310 0.000
Y83.3 Surgical operation with formation of external stoma
0.690 0.310 0.000
Y44.2 Anticoagulants
0.690 0.310 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.690 0.310 0.000
M06.8 Other specified rheumatoid arthritis
0.689 0.310 0.000
M06.4 Inflammatory polyarthropathy
0.689 0.310 0.000
M06.2 Rheumatoid bursitis
0.689 0.310 0.000
M06.1 Adult-onset Still's disease
0.689 0.310 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.689 0.311 0.000
C95 Leukaemia of unspecified cell type
0.689 0.311 0.000
C94 Other leukaemias of specified cell type
0.689 0.311 0.000
C93 Monocytic leukaemia
0.689 0.311 0.000
C88 Malignant immunoproliferative diseases
0.689 0.311 0.000
C86 Other specified types of T/NK-cell lymphoma
0.689 0.311 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.689 0.311 0.000
M23.5 Chronic instability of knee
0.689 0.311 0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.689 0.311 0.000
D64.9 Anaemia, unspecified
0.688 0.312 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.688 0.312 0.000
H10-H13 Disorders of conjunctiva
0.688 0.312 0.000
D51 Vitamin B12 deficiency anaemia
0.687 0.313 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.687 0.313 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.687 0.313 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.684 0.315 0.000
M21.0 Valgus deformity, not elsewhere classified
0.684 0.316 0.000
E22 Hyperfunction of pituitary gland
0.683 0.316 0.000
E61 Deficiency of other nutrient elements
0.683 0.317 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.682 0.318 0.000
B35-B49 Mycoses
0.680 0.320 0.000
Y83.5 Amputation of limb(s)
0.680 0.320 0.000
D10-D36 Benign neoplasms
0.679 0.321 0.000
F01 Vascular dementia
0.679 0.321 0.000
W13 Fall from, out of or through building or structure
0.679 0.321 0.000
Y54.3 Benzothiadiazine derivatives
0.678 0.322 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.678 0.322 0.000
C67.2 Lateral wall of bladder
0.678 0.322 0.000
G44 Other headache syndromes
0.678 0.322 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.677 0.323 0.000
M16.7 Other secondary coxarthrosis
0.677 0.323 0.000
H40 Glaucoma
0.677 0.323 0.000
G20 Parkinson's disease
0.675 0.325 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.675 0.325 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.674 0.326 0.000
V10-V19 Pedal cyclist injured in transport accident
0.674 0.326 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.674 0.326 0.000
M25.74 Osteophyte (Hand)
0.673 0.327 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.672 0.328 0.000
Y88 Sequelae of surgical and medical care as external cause
0.672 0.328 0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.671 0.329 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.671 0.329 0.000
Q80-Q89 Other congenital malformations
0.671 0.329 0.000
Q35-Q37 Cleft lip and cleft palate
0.671 0.329 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.671 0.329 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.671 0.329 0.000
Q00-Q07 Congenital malformations of the nervous system
0.671 0.329 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.670 0.330 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.670 0.330 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.670 0.330 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.670 0.330 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.670 0.330 0.000
C54 Malignant neoplasm of corpus uteri
0.669 0.331 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.669 0.331 0.000
M46 Other inflammatory spondylopathies
0.669 0.331 0.000
M07 Psoriatic and enteropathic arthropathies
0.669 0.331 0.000
M24.1 Other articular cartilage disorders
0.669 0.331 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.668 0.332 0.000
D86 Sarcoidosis
0.667 0.332 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.667 0.333 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.667 0.333 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.667 0.333 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.667 0.333 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.667 0.333 0.000
M87 Osteonecrosis
0.665 0.334 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.665 0.335 0.000
M21.3 Wrist or foot drop (acquired)
0.665 0.335 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.665 0.335 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.664 0.335 0.000
E13 Other specified diabetes mellitus
0.664 0.336 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.662 0.338 0.000
T39.0 Salicylates
0.662 0.338 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.662 0.338 0.000
G83 Other paralytic syndromes
0.661 0.338 0.000
M23.8 Other internal derangements of knee
0.661 0.339 0.000
M25.9 Joint disorder, unspecified
0.660 0.340 0.000
M25.3 Other instability of joint
0.660 0.340 0.000
M25.2 Flail joint
0.660 0.340 0.000
M25.1 Fistula of joint
0.660 0.340 0.000
M25.0 Haemarthrosis
0.660 0.340 0.000
G31.8 Other specified degenerative diseases of nervous system
0.659 0.341 0.000
Y84.8 Other medical procedures
0.659 0.341 0.000
H43-H45 Disorders of vitreous body and globe
0.658 0.341 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.658 0.342 0.000
M66 Spontaneous rupture of synovium and tendon
0.658 0.342 0.000
T98 Sequelae of other and unspecified effects of external causes
0.658 0.342 0.000
T95 Sequelae of burns, corrosions and frostbite
0.658 0.342 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.658 0.342 0.000
T91 Sequelae of injuries of neck and trunk
0.658 0.342 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.658 0.342 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.658 0.342 0.000
M17.1 Other primary gonarthrosis
0.657 0.343 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.657 0.343 0.000
M06.34 Rheumatoid nodule (Hand)
0.656 0.344 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.655 0.345 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.655 0.345 0.000
M23.3 Other meniscus derangements
0.655 0.345 0.000
C16 Malignant neoplasm of stomach
0.654 0.346 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.653 0.347 0.000
T43.9 Psychotropic drug, unspecified
0.653 0.347 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.653 0.347 0.000
T43.6 Psychostimulants with abuse potential
0.653 0.347 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.653 0.347 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.653 0.347 0.000
M17.5 Other secondary gonarthrosis
0.652 0.348 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.652 0.348 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.652 0.348 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.652 0.348 0.000
Y89 Sequelae of other external causes
0.652 0.348 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.652 0.348 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.651 0.349 0.000
F02 Dementia in other diseases classified elsewhere
0.651 0.349 0.000
F09 Unspecified organic or symptomatic mental disorder
0.651 0.349 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.651 0.349 0.000
G82 Paraplegia and tetraplegia
0.651 0.349 0.000
F32.9 Depressive episode, unspecified
0.651 0.349 0.000
M88 Paget's disease of bone [osteitis deformans]
0.649 0.351 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.649 0.351 0.000
F05.9 Delirium, unspecified
0.649 0.351 0.000
E14.3 With ophthalmic complications
0.648 0.352 0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.647 0.353 0.000
W06 Fall involving bed
0.647 0.353 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.647 0.353 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.647 0.353 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.646 0.353 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.646 0.354 0.000
E27 Other disorders of adrenal gland
0.645 0.354 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.645 0.355 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.643 0.357 0.000
M22 Disorders of patella
0.643 0.357 0.000
S42 Fracture of shoulder and upper arm
0.642 0.358 0.000
M19.8 Other specified arthrosis
0.641 0.359 0.000
M19.2 Other secondary arthrosis
0.641 0.359 0.000
W19 Unspecified fall
0.641 0.359 0.000
E23 Hypofunction and other disorders of pituitary gland
0.641 0.359 0.000
M19.1 Posttraumatic arthrosis of other joints
0.640 0.360 0.000
M25.71 Osteophyte (Shoulder region)
0.639 0.361 0.000
G80 Infantile cerebral palsy
0.639 0.361 0.000
C68 Malignant neoplasm of other and unspecified urinary organs
0.639 0.361 0.000
C66 Malignant neoplasm of ureter
0.639 0.361 0.000
C65 Malignant neoplasm of renal pelvis
0.639 0.361 0.000
G31.2 Degeneration of nervous system due to alcohol
0.638 0.361 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.638 0.361 0.000
G31.0 Circumscribed brain atrophy
0.638 0.361 0.000
M48.06 Spinal stenosis (Lumbar region)
0.638 0.362 0.000
E28.2 Polycystic ovarian syndrome
0.638 0.362 0.000
Y43.9 Primarily systemic agent, unspecified
0.638 0.362 0.000
Y43.8 Other primarily systemic agents, not elsewhere classified
0.638 0.362 0.000
Y43.6 Enzymes, not elsewhere classified
0.638 0.362 0.000
Y43.5 Acidifying and alkalising agents
0.638 0.362 0.000
Y43.4 Immunosuppressive agents
0.638 0.362 0.000
Y43.2 Antineoplastic natural products
0.638 0.362 0.000
Y43.1 Antineoplastic antimetabolites
0.638 0.362 0.000
Y43.0 Antiallergic and antiemetic drugs
0.638 0.362 0.000
M23.9 Internal derangement of knee, unspecified
0.636 0.364 0.000
M23.1 Discoid meniscus (congenital)
0.636 0.364 0.000
M23.0 Cystic meniscus
0.636 0.364 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.634 0.365 0.000
C77.9 Lymph node, unspecified
0.634 0.366 0.000
T51 Toxic effect of alcohol
0.633 0.367 0.000
E12 Malnutrition-related diabetes mellitus
0.632 0.368 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.632 0.368 0.000
E34 Other endocrine disorders
0.632 0.368 0.000
E32 Diseases of thymus
0.632 0.368 0.000
E31 Polyglandular dysfunction
0.632 0.368 0.000
E30 Disorders of puberty, not elsewhere classified
0.632 0.368 0.000
E29 Testicular dysfunction
0.632 0.368 0.000
E26 Hyperaldosteronism
0.632 0.368 0.000
E25 Adrenogenital disorders
0.632 0.368 0.000
E24 Cushing's syndrome
0.632 0.368 0.000
E20 Hypoparathyroidism
0.632 0.368 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.632 0.368 0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.632 0.368 0.000
M43 Other deforming dorsopathies
0.631 0.369 0.000
M25.76 Osteophyte (Lower leg)
0.631 0.369 0.000
D61 Other aplastic anaemias
0.630 0.370 0.000
M10.4 Other secondary gout
0.630 0.370 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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