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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs117291831
log Bayes Factor = 7.6951
Chromosome 12   position 127,045,967  (GRCh37) Explore rs117291831 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.998 0.002 0.000
I25.2 Old myocardial infarction
0.996 0.004 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.995 0.005 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.995 0.005 0.000
Chapter VII Diseases of the eye and adnexa
0.995 0.005 0.000
Chapter XX External causes of morbidity and mortality
0.994 0.006 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.994 0.006 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.993 0.007 0.000
H04 Disorders of lachrymal system
0.985 0.015 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.976 0.024 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.974 0.026 0.000
I20 Angina pectoris
0.971 0.029 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.970 0.030 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.969 0.031 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.968 0.032 0.000
I20.0 Unstable angina
0.967 0.033 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.962 0.038 0.000
H04.2 Epiphora
0.961 0.039 0.000
I50 Heart failure
0.957 0.043 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.957 0.043 0.000
R26 Abnormalities of gait and mobility
0.952 0.048 0.000
M70-M79 Other soft tissue disorders
0.947 0.053 0.000
H02 Other disorders of eyelid
0.942 0.058 0.000
R20 Disturbances of skin sensation
0.942 0.058 0.000
I50.9 Heart failure, unspecified
0.939 0.061 0.000
I51 Complications and ill-defined descriptions of heart disease
0.937 0.063 0.000
I22 Subsequent myocardial infarction
0.934 0.066 0.000
V10-V19 Pedal cyclist injured in transport accident
0.930 0.070 0.000
M75 Shoulder lesions
0.930 0.070 0.000
I95 Hypotension
0.928 0.072 0.000
I35 Nonrheumatic aortic valve disorders
0.923 0.077 0.000
I44 Atrioventricular and left bundle-branch block
0.922 0.078 0.000
R20.2 Paraesthesia of skin
0.917 0.083 0.000
Chapter VI Diseases of the nervous system
0.914 0.086 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.913 0.087 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.911 0.089 0.000
I95.9 Hypotension, unspecified
0.910 0.090 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.909 0.091 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.902 0.098 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.897 0.103 0.000
T90 Sequelae of injuries of head
0.896 0.104 0.000
T93 Sequelae of injuries of lower limb
0.892 0.108 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.887 0.113 0.000
H02.3 Blepharochalasis
0.886 0.114 0.000
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension
0.885 0.115 0.000
I60-I69 Cerebrovascular diseases
0.882 0.118 0.000
M20-M25 Other joint disorders
0.881 0.119 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.878 0.122 0.000
S10-S19 Injuries to the neck
0.877 0.123 0.000
I51.9 Heart disease, unspecified
0.876 0.124 0.000
I42 Cardiomyopathy
0.870 0.130 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.869 0.131 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.869 0.131 0.000
H00 Hordeolum and chalazion
0.863 0.137 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.860 0.140 0.000
M75.0 Adhesive capsulitis of shoulder
0.855 0.145 0.000
H02.4 Ptosis of eyelid
0.854 0.146 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.852 0.148 0.000
M80-M85 Disorders of bone density and structure
0.852 0.148 0.000
M75.1 Rotator cuff syndrome
0.852 0.148 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.850 0.150 0.000
H43-H45 Disorders of vitreous body and globe
0.848 0.152 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.844 0.156 0.000
I44.7 Left bundle-branch block, unspecified
0.843 0.157 0.000
R07 Pain in throat and chest
0.841 0.159 0.000
Y52 Agents primarily affecting the cardiovascular system
0.838 0.162 0.000
G90-G99 Other disorders of the nervous system
0.835 0.165 0.000
M22 Disorders of patella
0.833 0.167 0.000
R07.2 Precordial pain
0.830 0.170 0.000
I46 Cardiac arrest
0.829 0.171 0.000
I45 Other conduction disorders
0.829 0.171 0.000
G40-G47 Episodic and paroxysmal disorders
0.824 0.176 0.000
T17 Foreign body in respiratory tract
0.822 0.178 0.000
T93.0 Sequelae of open wound of lower limb
0.820 0.180 0.000
S80-S89 Injuries to the knee and lower leg
0.818 0.182 0.000
I25.1 Atherosclerotic heart disease
0.815 0.185 0.000
R25 Abnormal involuntary movements
0.815 0.185 0.000
H04.8 Other disorders of lachrymal system
0.815 0.185 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.814 0.186 0.000
H02.5 Other disorders affecting eyelid function
0.812 0.188 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.811 0.189 0.000
X50-X57 Overexertion, travel and privation
0.811 0.189 0.000
I44.2 Atrioventricular block, complete
0.810 0.190 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.810 0.190 0.000
T90.4 Sequelae of injury of eye and orbit
0.807 0.193 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.804 0.196 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.802 0.198 0.000
R26.3 Immobility
0.800 0.199 0.000
M60-M63 Disorders of muscles
0.798 0.202 0.000
H55-H59 Other disorders of eye and adnexa
0.798 0.202 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.797 0.203 0.000
I30 Acute pericarditis
0.797 0.203 0.000
R01 Cardiac murmurs and other cardiac sounds
0.795 0.205 0.000
S40-S49 Injuries to the shoulder and upper arm
0.794 0.206 0.000
T92 Sequelae of injuries of upper limb
0.792 0.208 0.000
Y57 Other and unspecified drugs and medicaments
0.791 0.209 0.000
S70-S79 Injuries to the hip and thigh
0.791 0.209 0.000
G43 Migraine
0.788 0.212 0.000
M75.3 Calcific tendinitis of shoulder
0.784 0.216 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.784 0.216 0.000
S90-S99 Injuries to the ankle and foot
0.784 0.216 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.780 0.219 0.000
H00.0 Hordeolum and other deep inflammation of eyelid
0.778 0.222 0.000
I51.8 Other ill-defined heart diseases
0.777 0.223 0.000
R47-R49 Symptoms and signs involving speech and voice
0.776 0.224 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.775 0.225 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.773 0.227 0.000
X60-X84 Intentional self-harm
0.773 0.227 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.773 0.227 0.000
I47 Paroxysmal tachycardia
0.769 0.231 0.000
H18 Other disorders of cornea
0.768 0.232 0.000
T79-T79 Certain early complications of trauma
0.768 0.232 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.768 0.232 0.000
S19 Other and unspecified injuries of neck
0.767 0.233 0.000
M75.2 Bicipital tendinitis
0.766 0.234 0.000
I38 Endocarditis, valve unspecified
0.765 0.235 0.000
I61 Intracerebral haemorrhage
0.765 0.235 0.000
W50-W64 Exposure to animate mechanical forces
0.764 0.236 0.000
H01 Other inflammation of eyelid
0.764 0.236 0.000
I95.2 Hypotension due to drugs
0.763 0.237 0.000
R02 Gangrene, not elsewhere classified
0.762 0.238 0.000
V40-V49 Car occupant injured in transport accident
0.762 0.238 0.000
I25.5 Ischaemic cardiomyopathy
0.761 0.239 0.000
I24 Other acute ischaemic heart diseases
0.761 0.239 0.000
M20 Acquired deformities of fingers and toes
0.761 0.239 0.000
M22.4 Chondromalacia patellae
0.760 0.240 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.760 0.240 0.000
I35.8 Other aortic valve disorders
0.758 0.242 0.000
T00-T07 Injuries involving multiple body regions
0.758 0.242 0.000
M00-M03 Infectious arthropathies
0.758 0.242 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.756 0.244 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.756 0.244 0.000
H21 Other disorders of iris and ciliary body
0.753 0.247 0.000
H02.0 Entropion and trichiasis of eyelid
0.752 0.248 0.000
R09.0 Asphyxia
0.752 0.248 0.000
I46.0 Cardiac arrest with successful resuscitation
0.752 0.248 0.000
T91 Sequelae of injuries of neck and trunk
0.752 0.248 0.000
R22.0 Localised swelling, mass and lump, head
0.752 0.248 0.000
M20.4 Other hammer toe(s) (acquired)
0.751 0.249 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.750 0.250 0.000
I44.3 Other and unspecified atrioventricular block
0.750 0.250 0.000
R06 Abnormalities of breathing
0.750 0.250 0.000
H04.9 Disorder of lachrymal system, unspecified
0.748 0.252 0.000
H05 Disorders of orbit
0.747 0.253 0.000
W00-W19 Falls
0.746 0.254 0.000
I67 Other cerebrovascular diseases
0.746 0.254 0.000
G43.9 Migraine, unspecified
0.746 0.254 0.000
M80 Osteoporosis with pathological fracture
0.745 0.255 0.000
R27 Other lack of coordination
0.743 0.257 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.742 0.258 0.000
I35.9 Aortic valve disorder, unspecified
0.742 0.258 0.000
I69 Sequelae of cerebrovascular disease
0.741 0.259 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.741 0.259 0.000
X10-X19 Contact with heat and hot substances
0.741 0.259 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.741 0.259 0.000
R26.0 Ataxic gait
0.740 0.260 0.000
V18.2 Unspecified pedal cyclist injured in nontraffic accident
0.738 0.262 0.000
I36 Nonrheumatic tricuspid valve disorders
0.736 0.263 0.000
I45.9 Conduction disorder, unspecified
0.735 0.265 0.000
I37 Pulmonary valve disorders
0.734 0.266 0.000
S86 Injury of muscle and tendon at lower leg level
0.732 0.268 0.000
S89 Other and unspecified injuries of lower leg
0.732 0.268 0.000
H04.3 Acute and unspecified inflammation of lachrymal passages
0.732 0.268 0.000
R25.2 Cramp and spasm
0.732 0.268 0.000
R20.8 Other and unspecified disturbances of skin sensation
0.730 0.270 0.000
H43 Disorders of vitreous body
0.730 0.270 0.000
T20 Burn and corrosion of head and neck
0.730 0.270 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.730 0.270 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.729 0.271 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.729 0.271 0.000
T18 Foreign body in alimentary tract
0.728 0.272 0.000
T17.9 Foreign body in respiratory tract, part unspecified
0.728 0.272 0.000
V19 Pedal cyclist injured in other and unspecified transport accidents
0.728 0.272 0.000
V17 Pedal cyclist injured in collision with fixed or stationary object
0.726 0.274 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.725 0.274 0.000
I42.2 Other hypertrophic cardiomyopathy
0.725 0.275 0.000
T93.1 Sequelae of fracture of femur
0.725 0.275 0.000
V18.3 Person injured while boarding or alighting
0.724 0.276 0.000
I60 Subarachnoid haemorrhage
0.723 0.277 0.000
R22.4 Localised swelling, mass and lump, lower limb
0.723 0.277 0.000
M91-M94 Chondropathies
0.722 0.278 0.000
I05-I09 Chronic rheumatic heart diseases
0.722 0.278 0.000
R22.1 Localised swelling, mass and lump, neck
0.722 0.278 0.000
H02.1 Ectropion of eyelid
0.722 0.278 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.719 0.281 0.000
I10-I15 Hypertensive diseases
0.719 0.281 0.000
S50-S59 Injuries to the elbow and forearm
0.718 0.282 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
I25.6 Silent myocardial ischaemia
0.716 0.284 0.000
I25.4 Coronary artery aneurysm
0.716 0.284 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.716 0.284 0.000
Y57.9 Drug or medicament, unspecified
0.714 0.286 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.714 0.286 0.000
G91 Hydrocephalus
0.713 0.286 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.713 0.287 0.000
T33-T35 Frostbite
0.713 0.287 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.713 0.287 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.713 0.287 0.000
Y35-Y36 Legal intervention and operations of war
0.713 0.287 0.000
Y10-Y34 Event of undetermined intent
0.713 0.287 0.000
Y00-Y09 Assault
0.713 0.287 0.000
X85-X99 Assault
0.713 0.287 0.000
X30-X39 Exposure to forces of nature
0.713 0.287 0.000
X20-X29 Contact with venomous animals and plants
0.713 0.287 0.000
X00-X09 Exposure to smoke, fire and flames
0.713 0.287 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.713 0.287 0.000
W75-W84 Other accidental threats to breathing
0.713 0.287 0.000
W65-W74 Accidental drowning and submersion
0.713 0.287 0.000
V98-V99 Other and unspecified transport accidents
0.713 0.287 0.000
V95-V97 Air and space transport accidents
0.713 0.287 0.000
V90-V94 Water transport accidents
0.713 0.287 0.000
V70-V79 Bus occupant injured in transport accident
0.713 0.287 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.713 0.287 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.713 0.287 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.713 0.287 0.000
V01-V09 Pedestrian injured in transport accident
0.713 0.287 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.713 0.287 0.000
M22.2 Patellofemoral disorders
0.713 0.287 0.000
M75.9 Shoulder lesion, unspecified
0.712 0.288 0.000
T21 Burn and corrosion of trunk
0.711 0.289 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.710 0.290 0.000
H04.6 Other changes in lachrymal passages
0.706 0.294 0.000
H04.4 Chronic inflammation of lachrymal passages
0.706 0.294 0.000
H04.0 Dacryoadenitis
0.706 0.294 0.000
G30-G32 Other degenerative diseases of the nervous system
0.705 0.295 0.000
M79.2 Neuralgia and neuritis, unspecified
0.705 0.295 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.703 0.297 0.000
I51.6 Cardiovascular disease, unspecified
0.703 0.297 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.703 0.297 0.000
I67.9 Cerebrovascular disease, unspecified
0.703 0.297 0.000
H16 Keratitis
0.701 0.299 0.000
R22.9 Localised swelling, mass and lump, unspecified
0.700 0.300 0.000
T95 Sequelae of burns, corrosions and frostbite
0.699 0.300 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.699 0.300 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.699 0.300 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.699 0.300 0.000
I47.2 Ventricular tachycardia
0.698 0.302 0.000
S36 Injury of intra-abdominal organs
0.698 0.302 0.000
I25.3 Aneurysm of heart
0.697 0.303 0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.696 0.304 0.000
R09.1 Pleurisy
0.696 0.304 0.000
R29.4 Clicking hip
0.695 0.305 0.000
R29.3 Abnormal posture
0.695 0.305 0.000
R29.2 Abnormal reflex
0.695 0.305 0.000
R29.1 Meningismus
0.695 0.305 0.000
R29.0 Tetany
0.695 0.305 0.000
M32 Systemic lupus erythematosus
0.695 0.305 0.000
H20 Iridocyclitis
0.694 0.306 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.693 0.307 0.000
M86-M90 Other osteopathies
0.692 0.308 0.000
G40 Epilepsy
0.690 0.310 0.000
S19.9 Unspecified injury of neck
0.688 0.312 0.000
I33 Acute and subacute endocarditis
0.688 0.312 0.000
S10 Superficial injury of neck
0.687 0.312 0.000
Y48 Anaesthetics and therapeutic gases
0.685 0.315 0.000
G93 Other disorders of brain
0.685 0.315 0.000
R26.1 Paralytic gait
0.683 0.317 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.682 0.318 0.000
T98 Sequelae of other and unspecified effects of external causes
0.680 0.320 0.000
X51 Travel and motion
0.679 0.320 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.679 0.321 0.000
T66-T78 Other and unspecified effects of external causes
0.678 0.322 0.000
I21 Acute myocardial infarction
0.678 0.322 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.676 0.324 0.000
M30 Polyarteritis nodosa and related conditions
0.676 0.324 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.675 0.325 0.000
H02.2 Lagophthalmos
0.675 0.325 0.000
R20.3 Hyperaesthesia
0.675 0.325 0.000
R20.1 Hypoaesthesia of skin
0.675 0.325 0.000
R20.0 Anaesthesia of skin
0.675 0.325 0.000
I34 Nonrheumatic mitral valve disorders
0.675 0.325 0.000
V20-V29 Motorcycle rider injured in transport accident
0.674 0.326 0.000
T93.8 Sequelae of other specified injuries of lower limb
0.674 0.326 0.000
M62 Other disorders of muscle
0.673 0.327 0.000
I51.5 Myocardial degeneration
0.672 0.328 0.000
I51.4 Myocarditis, unspecified
0.672 0.328 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.672 0.328 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.672 0.328 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.672 0.328 0.000
I51.0 Cardiac septal defect, acquired
0.672 0.328 0.000
S32 Fracture of lumbar spine and pelvis
0.671 0.329 0.000
G90 Disorders of autonomic nervous system
0.671 0.329 0.000
G70-G73 Diseases of myoneural junction and muscle
0.671 0.329 0.000
S89.9 Unspecified injury of lower leg
0.671 0.329 0.000
M24 Other specific joint derangements
0.671 0.329 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.670 0.329 0.000
I22.8 Subsequent myocardial infarction of other sites
0.669 0.330 0.000
M40-M43 Deforming dorsopathies
0.667 0.333 0.000
V16 Pedal cyclist injured in collision with other nonmotor vehicle
0.666 0.333 0.000
V15 Pedal cyclist injured in collision with railway train or railway vehicle
0.666 0.333 0.000
V14 Pedal cyclist injured in collision with heavy transport vehicle or bus
0.666 0.333 0.000
V13 Pedal cyclist injured in collision with car, pick-up truck or van
0.666 0.333 0.000
V12 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle
0.666 0.333 0.000
V11 Pedal cyclist injured in collision with other pedal cycle
0.666 0.333 0.000
V10 Pedal cyclist injured in collision with pedestrian or animal
0.666 0.333 0.000
M75.8 Other shoulder lesions
0.666 0.333 0.000
T17.2 Foreign body in pharynx
0.666 0.334 0.000
R47 Speech disturbances, not elsewhere classified
0.666 0.334 0.000
I95.8 Other hypotension
0.665 0.335 0.000
I95.0 Idiopathic hypotension
0.665 0.335 0.000
Y79 Orthopaedic devices associated with adverse incidents
0.665 0.335 0.000
S81 Open wound of lower leg
0.665 0.335 0.000
Chapter XXII Codes for special purposes
0.664 0.336 0.000
R06.2 Wheezing
0.664 0.336 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.664 0.336 0.000
M76 Enthesopathies of lower limb, excluding foot
0.663 0.337 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.662 0.337 0.000
I44.5 Left posterior fascicular block
0.661 0.339 0.000
I44.4 Left anterior fascicular block
0.661 0.339 0.000
T90.5 Sequelae of intracranial injury
0.660 0.340 0.000
W07 Fall involving chair
0.660 0.340 0.000
V80-V89 Other land transport accidents
0.659 0.340 0.000
M82 Osteoporosis in diseases classified elsewhere
0.659 0.341 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.659 0.341 0.000
M79.8 Other specified soft tissue disorders
0.657 0.343 0.000
R22.3 Localised swelling, mass and lump, upper limb
0.656 0.343 0.000
I44.6 Other and unspecified fascicular block
0.656 0.344 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.656 0.344 0.000
M75.5 Bursitis of shoulder
0.655 0.345 0.000
H18.4 Corneal degeneration
0.655 0.345 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.654 0.346 0.000
I97.2 Postmastectomy lymphoedema syndrome
0.654 0.346 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.653 0.347 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.653 0.347 0.000
H17 Corneal scars and opacities
0.653 0.347 0.000
H15 Disorders of sclera
0.653 0.347 0.000
T19 Foreign body in genito-urinary tract
0.652 0.348 0.000
T15 Foreign body on external eye
0.652 0.348 0.000
T16 Foreign body in ear
0.652 0.348 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.651 0.348 0.000
I35.0 Aortic (valve) stenosis
0.650 0.350 0.000
G43.1 Migraine with aura [classical migraine]
0.650 0.350 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.649 0.350 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.649 0.350 0.000
M20.0 Deformity of finger(s)
0.649 0.351 0.000
R05 Cough
0.649 0.351 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.649 0.351 0.000
Y44 Agents primarily affecting blood constituents
0.648 0.352 0.000
Y59 Other and unspecified vaccines and biological substances
0.647 0.353 0.000
Y58 Bacterial vaccines
0.647 0.353 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.647 0.353 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.647 0.353 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.647 0.353 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.647 0.353 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.647 0.353 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.647 0.353 0.000
I42.6 Alcoholic cardiomyopathy
0.645 0.355 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.645 0.355 0.000
S12 Fracture of neck
0.645 0.355 0.000
G96 Other disorders of central nervous system
0.645 0.355 0.000
M71 Other bursopathies
0.644 0.356 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.644 0.356 0.000
M79.7 Fibromyalgia
0.644 0.356 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.644 0.356 0.000
R22.7 Localised swelling, mass and lump, multiple sites
0.643 0.357 0.000
M25 Other joint disorders, not elsewhere classified
0.643 0.357 0.000
S72 Fracture of femur
0.643 0.357 0.000
T90.8 Sequelae of other specified injuries of head
0.642 0.357 0.000
T90.3 Sequelae of injury of cranial nerves
0.642 0.357 0.000
T90.1 Sequelae of open wound of head
0.642 0.357 0.000
T90.0 Sequelae of superficial injury of head
0.642 0.357 0.000
I35.1 Aortic (valve) insufficiency
0.642 0.358 0.000
R22.2 Localised swelling, mass and lump, trunk
0.641 0.359 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.640 0.359 0.000
M96.1 Postlaminectomy syndrome, not elsewhere classified
0.640 0.360 0.000
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb
0.640 0.360 0.000
T93.5 Sequelae of injury of muscle and tendon of lower limb
0.640 0.360 0.000
T93.4 Sequelae of injury of nerve of lower limb
0.640 0.360 0.000
I45.2 Bifascicular block
0.639 0.361 0.000
M79.28 Neuralgia and neuritis, unspecified (Other)
0.639 0.361 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.638 0.362 0.000
M31 Other necrotising vasculopathies
0.636 0.364 0.000
H44 Disorders of globe
0.635 0.365 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.635 0.365 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.634 0.366 0.000
R01.1 Cardiac murmur, unspecified
0.633 0.367 0.000
I42.8 Other cardiomyopathies
0.633 0.367 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.632 0.368 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.632 0.368 0.000
W20-W49 Exposure to inanimate mechanical forces
0.632 0.368 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.632 0.368 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.632 0.368 0.000
M33 Dermatopolymyositis
0.632 0.368 0.000
V18.0 Driver injured in nontraffic accident
0.631 0.368 0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.631 0.369 0.000
G41 Status epilepticus
0.630 0.370 0.000
M05-M14 Inflammatory polyarthropathies
0.630 0.370 0.000
T20.1 Burn of first degree of head and neck
0.630 0.370 0.000
I50.1 Left ventricular failure
0.630 0.370 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.629 0.371 0.000
S37 Injury of urinary and pelvic organs
0.629 0.371 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.629 0.371 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.629 0.371 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.629 0.371 0.000
S31 Open wound of abdomen, lower back and pelvis
0.629 0.371 0.000
S17 Crushing injury of neck
0.629 0.371 0.000
S15 Injury of blood vessels at neck level
0.629 0.371 0.000
S14 Injury of nerves and spinal cord at neck level
0.629 0.371 0.000
S11 Open wound of neck
0.629 0.371 0.000
S18 Traumatic amputation at neck level
0.629 0.371 0.000
S16 Injury of muscle and tendon at neck level
0.629 0.371 0.000
M96.0 Pseudarthrosis after fusion or arthrodesis
0.628 0.372 0.000
I62 Other nontraumatic intracranial haemorrhage
0.627 0.373 0.000
I30.1 Infective pericarditis
0.627 0.373 0.000
G04 Encephalitis, myelitis and encephalomyelitis
0.627 0.373 0.000
H10-H13 Disorders of conjunctiva
0.626 0.374 0.000
R04 Haemorrhage from respiratory passages
0.626 0.374 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.625 0.375 0.000
S30.1 Contusion of abdominal wall
0.625 0.375 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.624 0.376 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.624 0.376 0.000
I42.5 Other restrictive cardiomyopathy
0.624 0.376 0.000
I42.4 Endocardial fibroelastosis
0.624 0.376 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.624 0.376 0.000
T25 Burn and corrosion of ankle and foot
0.623 0.377 0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot
0.623 0.377 0.000
T23 Burn and corrosion of wrist and hand
0.623 0.377 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.623 0.377 0.000
S86.8 Injury of other muscles and tendons at lower leg level
0.623 0.377 0.000
G00 Bacterial meningitis, not elsewhere classified
0.622 0.377 0.000
I49 Other cardiac arrhythmias
0.622 0.378 0.000
M81 Osteoporosis without pathological fracture
0.622 0.378 0.000
R01.0 Benign and innocent cardiac murmurs
0.622 0.378 0.000
I20.1 Angina pectoris with documented spasm
0.621 0.379 0.000
M21 Other acquired deformities of limbs
0.620 0.380 0.000
R80 Isolated proteinuria
0.620 0.380 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.620 0.380 0.000
I69.3 Sequelae of cerebral infarction
0.618 0.382 0.000
M84 Disorders of continuity of bone
0.618 0.382 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.618 0.382 0.000
H59.8 Other postprocedural disorders of eye and adnexa
0.618 0.382 0.000
R25.3 Fasciculation
0.617 0.383 0.000
M99 Biomechanical lesions, not elsewhere classified
0.617 0.383 0.000
M79.1 Myalgia
0.617 0.383 0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.616 0.384 0.000
M65-M68 Disorders of synovium and tendon
0.616 0.384 0.000
I44.1 Atrioventricular block, second degree
0.615 0.385 0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care
0.615 0.385 0.000
H21.8 Other specified disorders of iris and ciliary body
0.615 0.385 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.614 0.386 0.000
G91.9 Hydrocephalus, unspecified
0.614 0.386 0.000
S90 Superficial injury of ankle and foot
0.614 0.386 0.000
T92.0 Sequelae of open wound of upper limb
0.614 0.386 0.000
S40 Superficial injury of shoulder and upper arm
0.614 0.386 0.000
R06.6 Hiccough
0.613 0.387 0.000
I45.8 Other specified conduction disorders
0.612 0.387 0.000
M22.3 Other derangements of patella
0.612 0.388 0.000
X63 Intentional self-poisoning by and exposure to other drugs acting on the autonomic nervous system
0.612 0.388 0.000
H02.6 Xanthelasma of eyelid
0.611 0.388 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.611 0.389 0.000
V18.9 Unspecified pedal cyclist injured in traffic accident
0.611 0.389 0.000
V18.4 Driver injured in traffic accident
0.611 0.389 0.000
V18.5 Passenger injured in traffic accident
0.611 0.389 0.000
V18.1 Passenger injured in nontraffic accident
0.611 0.389 0.000
M83 Adult osteomalacia
0.611 0.389 0.000
H43.3 Other vitreous opacities
0.610 0.390 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.609 0.390 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.609 0.390 0.000
R27.8 Other and unspecified lack of coordination
0.609 0.391 0.000
M20.2 Hallux rigidus
0.609 0.391 0.000
G94.1 Hydrocephalus in neoplastic disease
0.608 0.391 0.000
T90.9 Sequelae of unspecified injury of head
0.608 0.392 0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.608 0.392 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.606 0.394 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.605 0.395 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.604 0.396 0.000
I30.9 Acute pericarditis, unspecified
0.604 0.396 0.000
M00 Pyogenic arthritis
0.603 0.397 0.000
I99 Other and unspecified disorders of circulatory system
0.603 0.397 0.000
M70.2 Olecranon bursitis
0.602 0.398 0.000
T91.9 Sequelae of unspecified injury of neck and trunk
0.601 0.399 0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system
0.601 0.399 0.000
Y52.8 Antivaricose drugs, including sclerosing agents
0.601 0.399 0.000
Y52.7 Peripheral vasodilators
0.601 0.399 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.601 0.399 0.000
Y52.1 Calcium-channel blockers
0.601 0.399 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.601 0.399 0.000
G20-G26 Extrapyramidal and movement disorders
0.600 0.400 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.599 0.401 0.000
G92 Toxic encephalopathy
0.599 0.401 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.599 0.401 0.000
T18.9 Foreign body in alimentary tract, part unspecified
0.598 0.402 0.000
M22.8 Other disorders of patella
0.598 0.402 0.000
X58 Exposure to other specified factors
0.598 0.402 0.000
T21.2 Burn of second degree of trunk
0.597 0.402 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.597 0.403 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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