TreeWAS – Variant ID: rs12147450

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M81.9 Osteoporosis, unspecified	0.036	0.964	0.000
M81.99 Osteoporosis, unspecified (Site unspecified)	0.036	0.964	0.000
M81.98 Osteoporosis, unspecified (Other)	0.033	0.967	0.000
M81 Osteoporosis without pathological fracture	0.031	0.969	0.000
M81.96 Osteoporosis, unspecified (Lower leg)	0.030	0.969	0.000
M81.4 Drug-induced osteoporosis	0.030	0.970	0.000
M81.40 Drug-induced osteoporosis (Multiple sites)	0.029	0.971	0.000
I60 Subarachnoid haemorrhage	0.028	0.972	0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery	0.027	0.973	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.027	0.973	0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.026	0.974	0.000
I67.8 Other specified cerebrovascular diseases	0.026	0.974	0.000
I67 Other cerebrovascular diseases	0.026	0.974	0.000
M81.94 Osteoporosis, unspecified (Hand)	0.026	0.974	0.000
M81.93 Osteoporosis, unspecified (Forearm)	0.026	0.974	0.000
M81.92 Osteoporosis, unspecified (Upper arm)	0.026	0.974	0.000
M81.91 Osteoporosis, unspecified (Shoulder region)	0.026	0.974	0.000
I67.1 Cerebral aneurysm, nonruptured	0.026	0.974	0.000
I60-I69 Cerebrovascular diseases	0.024	0.976	0.000
I69 Sequelae of cerebrovascular disease	0.024	0.976	0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified	0.024	0.976	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.024	0.976	0.000
I60.9 Subarachnoid haemorrhage, unspecified	0.024	0.976	0.000
M81.0 Postmenopausal osteoporosis	0.023	0.977	0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.023	0.977	0.000
I69.3 Sequelae of cerebral infarction	0.023	0.977	0.000
M81.8 Other osteoporosis	0.023	0.977	0.000
M81.6 Localised osteoporosis [Lequesne]	0.023	0.977	0.000
M81.5 Idiopathic osteoporosis	0.023	0.977	0.000
M81.1 Postoophorectomy osteoporosis	0.023	0.977	0.000
M81.49 Drug-induced osteoporosis (Site unspecified)	0.022	0.977	0.000
I60.8 Other subarachnoid haemorrhage	0.022	0.978	0.000
M81.2 Osteoporosis of disuse	0.022	0.978	0.000
M81.48 Drug-induced osteoporosis (Other)	0.022	0.978	0.000
M81.47 Drug-induced osteoporosis (Ankle and foot)	0.022	0.978	0.000
M81.46 Drug-induced osteoporosis (Lower leg)	0.022	0.978	0.000
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)	0.022	0.978	0.000
M81.44 Drug-induced osteoporosis (Hand)	0.022	0.978	0.000
M81.43 Drug-induced osteoporosis (Forearm)	0.022	0.978	0.000
M81.42 Drug-induced osteoporosis (Upper arm)	0.022	0.978	0.000
M81.41 Drug-induced osteoporosis (Shoulder region)	0.022	0.978	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.022	0.978	0.000
E20-E35 Disorders of other endocrine glands	0.022	0.978	0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery	0.022	0.978	0.000
I67.0 Dissection of cerebral arteries, nonruptured	0.021	0.979	0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.021	0.979	0.000
E21.3 Hyperparathyroidism, unspecified	0.021	0.979	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.021	0.979	0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.020	0.979	0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries	0.020	0.980	0.000
I60.5 Subarachnoid haemorrhage from vertebral artery	0.020	0.980	0.000
E34 Other endocrine disorders	0.020	0.980	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.020	0.980	0.000
E27 Other disorders of adrenal gland	0.020	0.980	0.000
I60.4 Subarachnoid haemorrhage from basilar artery	0.019	0.980	0.000
E26 Hyperaldosteronism	0.019	0.980	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.019	0.980	0.000
E22 Hyperfunction of pituitary gland	0.019	0.981	0.000
E34.9 Endocrine disorder, unspecified	0.019	0.981	0.000
I67.7 Cerebral arteritis, not elsewhere classified	0.019	0.981	0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system	0.019	0.981	0.000
I67.5 Moyamoya disease	0.019	0.981	0.000
I67.4 Hypertensive encephalopathy	0.019	0.981	0.000
I67.3 Progressive vascular leukoencephalopathy	0.019	0.981	0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery	0.019	0.981	0.000
E21.0 Primary hyperparathyroidism	0.019	0.981	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.019	0.981	0.000
M81.30 Postsurgical malabsorption osteoporosis (Multiple sites)	0.018	0.981	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.018	0.982	0.000
E23 Hypofunction and other disorders of pituitary gland	0.018	0.982	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.018	0.982	0.000
M81.09 Postmenopausal osteoporosis (Site unspecified)	0.018	0.982	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.017	0.982	0.000
E26.0 Primary hyperaldosteronism	0.017	0.982	0.000
M81.39 Postsurgical malabsorption osteoporosis (Site unspecified)	0.017	0.983	0.000
M81.38 Postsurgical malabsorption osteoporosis (Other)	0.017	0.983	0.000
M81.37 Postsurgical malabsorption osteoporosis (Ankle and foot)	0.017	0.983	0.000
M81.36 Postsurgical malabsorption osteoporosis (Lower leg)	0.017	0.983	0.000
M81.35 Postsurgical malabsorption osteoporosis (Pelvic region and thigh)	0.017	0.983	0.000
M81.34 Postsurgical malabsorption osteoporosis (Hand)	0.017	0.983	0.000
M81.33 Postsurgical malabsorption osteoporosis (Forearm)	0.017	0.983	0.000
M81.32 Postsurgical malabsorption osteoporosis (Upper arm)	0.017	0.983	0.000
M81.31 Postsurgical malabsorption osteoporosis (Shoulder region)	0.017	0.983	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.017	0.983	0.000
M81.08 Postmenopausal osteoporosis (Other)	0.017	0.983	0.000
M81.07 Postmenopausal osteoporosis (Ankle and foot)	0.017	0.983	0.000
M81.06 Postmenopausal osteoporosis (Lower leg)	0.017	0.983	0.000
M81.05 Postmenopausal osteoporosis (Pelvic region and thigh)	0.017	0.983	0.000
M81.04 Postmenopausal osteoporosis (Hand)	0.017	0.983	0.000
M81.03 Postmenopausal osteoporosis (Forearm)	0.017	0.983	0.000
M81.02 Postmenopausal osteoporosis (Upper arm)	0.017	0.983	0.000
M81.01 Postmenopausal osteoporosis (Shoulder region)	0.017	0.983	0.000
M81.00 Postmenopausal osteoporosis (Multiple sites)	0.017	0.983	0.000
E21.4 Other specified disorders of parathyroid gland	0.017	0.983	0.000
M81.19 Postoophorectomy osteoporosis (Site unspecified)	0.016	0.983	0.000
M81.18 Postoophorectomy osteoporosis (Other)	0.016	0.983	0.000
M81.17 Postoophorectomy osteoporosis (Ankle and foot)	0.016	0.983	0.000
M81.16 Postoophorectomy osteoporosis (Lower leg)	0.016	0.983	0.000
M81.15 Postoophorectomy osteoporosis (Pelvic region and thigh)	0.016	0.983	0.000
M81.14 Postoophorectomy osteoporosis (Hand)	0.016	0.983	0.000
M81.13 Postoophorectomy osteoporosis (Forearm)	0.016	0.983	0.000
M81.12 Postoophorectomy osteoporosis (Upper arm)	0.016	0.983	0.000
M81.11 Postoophorectomy osteoporosis (Shoulder region)	0.016	0.983	0.000
M81.10 Postoophorectomy osteoporosis (Multiple sites)	0.016	0.983	0.000
M81.59 Idiopathic osteoporosis (Site unspecified)	0.016	0.983	0.000
M81.58 Idiopathic osteoporosis (Other)	0.016	0.983	0.000
M81.57 Idiopathic osteoporosis (Ankle and foot)	0.016	0.983	0.000
M81.56 Idiopathic osteoporosis (Lower leg)	0.016	0.983	0.000
M81.55 Idiopathic osteoporosis (Pelvic region and thigh)	0.016	0.983	0.000
M81.54 Idiopathic osteoporosis (Hand)	0.016	0.983	0.000
M81.53 Idiopathic osteoporosis (Forearm)	0.016	0.983	0.000
M81.52 Idiopathic osteoporosis (Upper arm)	0.016	0.983	0.000
M81.51 Idiopathic osteoporosis (Shoulder region)	0.016	0.983	0.000
M81.50 Idiopathic osteoporosis (Multiple sites)	0.016	0.983	0.000
M81.69 Localized osteoporosis [Lequesne] (Site unspecified)	0.016	0.983	0.000
M81.68 Localized osteoporosis [Lequesne] (Other)	0.016	0.983	0.000
M81.67 Localized osteoporosis [Lequesne] (Ankle and foot)	0.016	0.983	0.000
M81.66 Localized osteoporosis [Lequesne] (Lower leg)	0.016	0.983	0.000
M81.65 Localized osteoporosis [Lequesne] (Pelvic region and thigh)	0.016	0.983	0.000
M81.64 Localized osteoporosis [Lequesne] (Hand)	0.016	0.983	0.000
M81.63 Localized osteoporosis [Lequesne] (Forearm)	0.016	0.983	0.000
M81.62 Localized osteoporosis [Lequesne] (Upper arm)	0.016	0.983	0.000
M81.61 Localized osteoporosis [Lequesne] (Shoulder region)	0.016	0.983	0.000
M81.60 Localized osteoporosis [Lequesne] (Multiple sites)	0.016	0.983	0.000
M81.89 Other osteoporosis (Site unspecified)	0.016	0.983	0.000
M81.88 Other osteoporosis (Other)	0.016	0.983	0.000
M81.87 Other osteoporosis (Ankle and foot)	0.016	0.983	0.000
M81.86 Other osteoporosis (Lower leg)	0.016	0.983	0.000
M81.85 Other osteoporosis (Pelvic region and thigh)	0.016	0.983	0.000
M81.84 Other osteoporosis (Hand)	0.016	0.983	0.000
M81.83 Other osteoporosis (Forearm)	0.016	0.983	0.000
M81.82 Other osteoporosis (Upper arm)	0.016	0.983	0.000
M81.81 Other osteoporosis (Shoulder region)	0.016	0.983	0.000
M81.80 Other osteoporosis (Multiple sites)	0.016	0.983	0.000
I62 Other nontraumatic intracranial haemorrhage	0.017	0.983	0.000
E27.2 Addisonian crisis	0.016	0.984	0.000
E27.1 Primary adrenocortical insufficiency	0.016	0.984	0.000
E27.8 Other specified disorders of adrenal gland	0.016	0.984	0.000
E28 Ovarian dysfunction	0.016	0.984	0.000
M81.29 Osteoporosis of disuse (Site unspecified)	0.016	0.984	0.000
M81.28 Osteoporosis of disuse (Other)	0.016	0.984	0.000
M81.27 Osteoporosis of disuse (Ankle and foot)	0.016	0.984	0.000
M81.26 Osteoporosis of disuse (Lower leg)	0.016	0.984	0.000
M81.25 Osteoporosis of disuse (Pelvic region and thigh)	0.016	0.984	0.000
M81.24 Osteoporosis of disuse (Hand)	0.016	0.984	0.000
M81.23 Osteoporosis of disuse (Forearm)	0.016	0.984	0.000
M81.22 Osteoporosis of disuse (Upper arm)	0.016	0.984	0.000
M81.21 Osteoporosis of disuse (Shoulder region)	0.016	0.984	0.000
I66.9 Occlusion and stenosis of unspecified cerebral artery	0.016	0.984	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.016	0.984	0.000
E21.2 Other hyperparathyroidism	0.016	0.984	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.016	0.984	0.000
E32 Diseases of thymus	0.016	0.984	0.000
E31 Polyglandular dysfunction	0.016	0.984	0.000
E30 Disorders of puberty, not elsewhere classified	0.016	0.984	0.000
E25 Adrenogenital disorders	0.016	0.984	0.000
M07.3 Other psoriatic arthropathies	0.016	0.984	0.000
E22.0 Acromegaly and pituitary gigantism	0.016	0.984	0.000
E26.9 Hyperaldosteronism, unspecified	0.015	0.985	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.015	0.985	0.000
E23.7 Disorder of pituitary gland, unspecified	0.015	0.985	0.000
M81.20 Osteoporosis of disuse (Multiple sites)	0.015	0.985	0.000
E34.0 Carcinoid syndrome	0.015	0.985	0.000
E23.0 Hypopituitarism	0.015	0.985	0.000
M80-M85 Disorders of bone density and structure	0.015	0.985	0.000
H33.2 Serous retinal detachment	0.000	0.985	0.015
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.014	0.985	0.000
E34.5 Androgen resistance syndrome	0.014	0.986	0.000
E34.4 Constitutional tall stature	0.014	0.986	0.000
E34.3 Short stature, not elsewhere classified	0.014	0.986	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.014	0.986	0.000
E34.1 Other hypersecretion of intestinal hormones	0.014	0.986	0.000
I66.0 Occlusion and stenosis of middle cerebral artery	0.014	0.986	0.000
E27.5 Adrenomedullary hyperfunction	0.014	0.986	0.000
E27.0 Other adrenocortical overactivity	0.014	0.986	0.000
E26.8 Other hyperaldosteronism	0.014	0.986	0.000
E26.1 Secondary hyperaldosteronism	0.014	0.986	0.000
I66.8 Occlusion and stenosis of other cerebral artery	0.014	0.986	0.000
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries	0.014	0.986	0.000
I66.3 Occlusion and stenosis of cerebellar arteries	0.014	0.986	0.000
I66.2 Occlusion and stenosis of posterior cerebral artery	0.014	0.986	0.000
I66.1 Occlusion and stenosis of anterior cerebral artery	0.014	0.986	0.000
E29 Testicular dysfunction	0.014	0.986	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.014	0.986	0.000
E22.8 Other hyperfunction of pituitary gland	0.014	0.986	0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified	0.014	0.986	0.000
E28.2 Polycystic ovarian syndrome	0.014	0.986	0.000
M07.34 Other psoriatic arthropathies (Hand)	0.014	0.986	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.013	0.986	0.000
E24 Cushing's syndrome	0.013	0.987	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.013	0.987	0.000
E23.1 Drug-induced hypopituitarism	0.013	0.987	0.000
E27.9 Disorder of adrenal gland, unspecified	0.013	0.987	0.000
E20 Hypoparathyroidism	0.013	0.987	0.000
E23.6 Other disorders of pituitary gland	0.013	0.987	0.000
M07.31 Other psoriatic arthropathies (Shoulder region)	0.013	0.987	0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere	0.013	0.987	0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere	0.013	0.987	0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere	0.013	0.987	0.000
M85 Other disorders of bone density and structure	0.013	0.987	0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.013	0.987	0.000
E34.8 Other specified endocrine disorders	0.012	0.987	0.000
I68.0 Cerebral amyloid angiopathy	0.012	0.987	0.000
E22.1 Hyperprolactinaemia	0.012	0.988	0.000
E23.2 Diabetes insipidus	0.012	0.988	0.000
M07.36 Other psoriatic arthropathies (Lower leg)	0.012	0.988	0.000
I62.1 Nontraumatic extradural haemorrhage	0.012	0.988	0.000
M84 Disorders of continuity of bone	0.012	0.988	0.000
I67.2 Cerebral atherosclerosis	0.012	0.988	0.000
E28.9 Ovarian dysfunction, unspecified	0.012	0.988	0.000
E28.8 Other ovarian dysfunction	0.012	0.988	0.000
E28.1 Androgen excess	0.012	0.988	0.000
E28.0 Oestrogen excess	0.012	0.988	0.000
E25.9 Adrenogenital disorder, unspecified	0.011	0.988	0.000
E25.8 Other adrenogenital disorders	0.011	0.988	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.011	0.988	0.000
E30.9 Disorder of puberty, unspecified	0.011	0.988	0.000
E30.8 Other disorders of puberty	0.011	0.988	0.000
E30.1 Precocious puberty	0.011	0.988	0.000
E30.0 Delayed puberty	0.011	0.988	0.000
E31.9 Polyglandular dysfunction, unspecified	0.011	0.988	0.000
E31.8 Other polyglandular dysfunction	0.011	0.988	0.000
E31.1 Polyglandular hyperfunction	0.011	0.988	0.000
E31.0 Autoimmune polyglandular failure	0.011	0.988	0.000
E32.9 Disease of thymus, unspecified	0.011	0.988	0.000
E32.8 Other diseases of thymus	0.011	0.988	0.000
E32.1 Abscess of thymus	0.011	0.988	0.000
E32.0 Persistent hyperplasia of thymus	0.011	0.988	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.011	0.988	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.011	0.988	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.011	0.988	0.000
M07.38 Other psoriatic arthropathies (Other)	0.011	0.988	0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.011	0.988	0.000
M07.33 Other psoriatic arthropathies (Forearm)	0.011	0.988	0.000
M07.32 Other psoriatic arthropathies (Upper arm)	0.011	0.988	0.000
M85.6 Other cyst of bone	0.011	0.989	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.011	0.989	0.000
I67.9 Cerebrovascular disease, unspecified	0.011	0.989	0.000
M83 Adult osteomalacia	0.011	0.989	0.000
M84.4 Pathological fracture, not elsewhere classified	0.010	0.990	0.000
E29.9 Testicular dysfunction, unspecified	0.010	0.990	0.000
E29.8 Other testicular dysfunction	0.010	0.990	0.000
E29.0 Testicular hyperfunction	0.010	0.990	0.000
M85.9 Disorder of bone density and structure, unspecified	0.010	0.990	0.000
M82 Osteoporosis in diseases classified elsewhere	0.010	0.990	0.000
E24.8 Other Cushing's syndrome	0.010	0.990	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.010	0.990	0.000
E24.3 Ectopic ACTH syndrome	0.010	0.990	0.000
E24.2 Drug-induced Cushing's syndrome	0.010	0.990	0.000
E24.1 Nelson's syndrome	0.010	0.990	0.000
Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device	0.010	0.990	0.000
E24.0 Pituitary-dependent Cushing's disease	0.010	0.990	0.000
I63 Cerebral infarction	0.010	0.990	0.000
E20.8 Other hypoparathyroidism	0.009	0.990	0.000
E20.1 Pseudohypoparathyroidism	0.009	0.990	0.000
E20.0 Idiopathic hypoparathyroidism	0.009	0.990	0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.010	0.990	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.009	0.990	0.000
M85.5 Aneurysmal bone cyst	0.009	0.990	0.000
M85.4 Solitary bone cyst	0.009	0.990	0.000
M85.3 Osteitis condensans	0.009	0.990	0.000
M85.2 Hyperostosis of skull	0.009	0.990	0.000
M85.1 Skeletal fluorosis	0.009	0.990	0.000
M85.65 Other cyst of bone (Pelvic region and thigh)	0.009	0.991	0.000
M85.8 Other specified disorders of bone density and structure	0.009	0.991	0.000
M07 Psoriatic and enteropathic arthropathies	0.009	0.991	0.000
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.009	0.991	0.000
M85.0 Fibrous dysplasia (monostotic)	0.009	0.991	0.000
M84.48 Pathological fracture, not elsewhere classified (Other)	0.009	0.991	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.009	0.991	0.000
E28.3 Primary ovarian failure	0.009	0.991	0.000
M84.9 Disorder of continuity of bone, unspecified	0.009	0.991	0.000
M84.3 Stress fracture, not elsewhere classified	0.009	0.991	0.000
M84.2 Delayed union of fracture	0.009	0.991	0.000
M85.64 Other cyst of bone (Hand)	0.009	0.991	0.000
M84.8 Other disorders of continuity of bone	0.009	0.991	0.000
E29.1 Testicular hypofunction	0.008	0.991	0.000
M85.95 Disorder of bone density and structure, unspecified (Pelvic region and thigh)	0.008	0.992	0.000
M85.67 Other cyst of bone (Ankle and foot)	0.008	0.992	0.000
M85.68 Other cyst of bone (Other)	0.008	0.992	0.000
M85.69 Other cyst of bone (Site unspecified)	0.008	0.992	0.000
M85.66 Other cyst of bone (Lower leg)	0.008	0.992	0.000
M85.63 Other cyst of bone (Forearm)	0.008	0.992	0.000
M85.62 Other cyst of bone (Upper arm)	0.008	0.992	0.000
M85.61 Other cyst of bone (Shoulder region)	0.008	0.992	0.000
M85.60 Other cyst of bone (Multiple sites)	0.008	0.992	0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.008	0.992	0.000
I65.8 Occlusion and stenosis of other precerebral artery	0.008	0.992	0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.008	0.992	0.000
I65.1 Occlusion and stenosis of basilar artery	0.008	0.992	0.000
I61 Intracerebral haemorrhage	0.008	0.992	0.000
M84.41 Pathological fracture, not elsewhere classified (Shoulder region)	0.008	0.992	0.000
M83.9 Adult osteomalacia, unspecified	0.008	0.992	0.000
M83.8 Other adult osteomalacia	0.008	0.992	0.000
M83.5 Other drug-induced osteomalacia in adults	0.008	0.992	0.000
M83.4 Aluminum bone disease	0.008	0.992	0.000
M83.3 Adult osteomalacia due to malnutrition	0.008	0.992	0.000
M83.2 Adult osteomalacia due to malabsorption	0.008	0.992	0.000
M83.1 Senile osteomalacia	0.008	0.992	0.000
M83.0 Puerperal osteomalacia	0.008	0.992	0.000
M84.0 Malunion of fracture	0.008	0.992	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.008	0.992	0.000
L08.9 Local infection of skin and subcutaneous tissue, unspecified	0.000	0.992	0.008
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.008	0.992	0.000
M84.49 Pathological fracture, not elsewhere classified (Site unspecified)	0.008	0.992	0.000
M84.47 Pathological fracture, not elsewhere classified (Ankle and foot)	0.008	0.992	0.000
M84.46 Pathological fracture, not elsewhere classified (Lower leg)	0.008	0.992	0.000
M84.44 Pathological fracture, not elsewhere classified (Hand)	0.008	0.992	0.000
M84.43 Pathological fracture, not elsewhere classified (Forearm)	0.008	0.992	0.000
M84.42 Pathological fracture, not elsewhere classified (Upper arm)	0.008	0.992	0.000
M84.40 Pathological fracture, not elsewhere classified (Multiple sites)	0.008	0.992	0.000
E24.9 Cushing's syndrome, unspecified	0.007	0.992	0.000
M85.99 Disorder of bone density and structure, unspecified (Site unspecified)	0.007	0.992	0.000
M85.98 Disorder of bone density and structure, unspecified (Other)	0.007	0.992	0.000
M85.97 Disorder of bone density and structure, unspecified (Ankle and foot)	0.007	0.992	0.000
M85.96 Disorder of bone density and structure, unspecified (Lower leg)	0.007	0.992	0.000
M85.94 Disorder of bone density and structure, unspecified (Hand)	0.007	0.992	0.000
M85.93 Disorder of bone density and structure, unspecified (Forearm)	0.007	0.992	0.000
M85.92 Disorder of bone density and structure, unspecified (Upper arm)	0.007	0.992	0.000
M85.91 Disorder of bone density and structure, unspecified (Shoulder region)	0.007	0.992	0.000
M85.90 Disorder of bone density and structure, unspecified (Multiple sites)	0.007	0.992	0.000
M84.45 Pathological fracture, not elsewhere classified (Pelvic region and thigh)	0.007	0.992	0.000
M82.8 Osteoporosis in other diseases classified elsewhere	0.007	0.992	0.000
M82.0 Osteoporosis in multiple myelomatosis	0.007	0.992	0.000
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.007	0.992	0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.007	0.992	0.000
M85.88 Other specified disorders of bone density and structure (Other)	0.007	0.993	0.000
M80 Osteoporosis with pathological fracture	0.007	0.993	0.000
E20.9 Hypoparathyroidism, unspecified	0.007	0.993	0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.007	0.993	0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.007	0.993	0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.007	0.993	0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)	0.007	0.993	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.007	0.993	0.000
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.007	0.993	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.007	0.993	0.000
M85.19 Skeletal fluorosis (Site unspecified)	0.007	0.993	0.000
M85.18 Skeletal fluorosis (Other)	0.007	0.993	0.000
M85.17 Skeletal fluorosis (Ankle and foot)	0.007	0.993	0.000
M85.16 Skeletal fluorosis (Lower leg)	0.007	0.993	0.000
M85.15 Skeletal fluorosis (Pelvic region and thigh)	0.007	0.993	0.000
M85.14 Skeletal fluorosis (Hand)	0.007	0.993	0.000
M85.13 Skeletal fluorosis (Forearm)	0.007	0.993	0.000
M85.12 Skeletal fluorosis (Upper arm)	0.007	0.993	0.000
M85.11 Skeletal fluorosis (Shoulder region)	0.007	0.993	0.000
M85.10 Skeletal fluorosis (Multiple sites)	0.007	0.993	0.000
M85.29 Hyperostosis of skull-Site unspec	0.007	0.993	0.000
M85.28 Hyperostosis of skull-Other	0.007	0.993	0.000
M85.27 Hyperostosis of skull-Ankle/Foot	0.007	0.993	0.000
M85.26 Hyperostosis of skull-Lower Leg	0.007	0.993	0.000
M85.25 Hyperostosis of skull-Pelvic/Thigh	0.007	0.993	0.000
M85.24 Hyperostosis of skull-Hand	0.007	0.993	0.000
M85.23 Hyperostosis of skull-Forearm	0.007	0.993	0.000
M85.22 Hyperostosis of skull-Upper arm	0.007	0.993	0.000
M85.21 Hyperostosis of skull-Shldr region	0.007	0.993	0.000
M85.20 Hyperostosis of skull-Mult sites	0.007	0.993	0.000
M85.39 Osteitis condensans (Site unspecified)	0.007	0.993	0.000
M85.38 Osteitis condensans (Other)	0.007	0.993	0.000
M85.37 Osteitis condensans (Ankle and foot)	0.007	0.993	0.000
M85.36 Osteitis condensans (Lower leg)	0.007	0.993	0.000
M85.35 Osteitis condensans (Pelvic region and thigh)	0.007	0.993	0.000
M85.34 Osteitis condensans (Hand)	0.007	0.993	0.000
M85.33 Osteitis condensans (Forearm)	0.007	0.993	0.000
M85.32 Osteitis condensans (Upper arm)	0.007	0.993	0.000
M85.31 Osteitis condensans (Shoulder region)	0.007	0.993	0.000
M85.30 Osteitis condensans (Multiple sites)	0.007	0.993	0.000
M85.49 Solitary bone cyst (Site unspecified)	0.007	0.993	0.000
M85.48 Solitary bone cyst (Other)	0.007	0.993	0.000
M85.47 Solitary bone cyst (Ankle and foot)	0.007	0.993	0.000
M85.46 Solitary bone cyst (Lower leg)	0.007	0.993	0.000
M85.45 Solitary bone cyst (Pelvic region and thigh)	0.007	0.993	0.000
M85.44 Solitary bone cyst (Hand)	0.007	0.993	0.000
M85.43 Solitary bone cyst (Forearm)	0.007	0.993	0.000
M85.42 Solitary bone cyst (Upper arm)	0.007	0.993	0.000
M85.41 Solitary bone cyst (Shoulder region)	0.007	0.993	0.000
M85.40 Solitary bone cyst (Multiple sites)	0.007	0.993	0.000
M85.59 Aneurysmal bone cyst (Site unspecified)	0.007	0.993	0.000
M85.58 Aneurysmal bone cyst (Other)	0.007	0.993	0.000
M85.57 Aneurysmal bone cyst (Ankle and foot)	0.007	0.993	0.000
M85.56 Aneurysmal bone cyst (Lower leg)	0.007	0.993	0.000
M85.55 Aneurysmal bone cyst (Pelvic region and thigh)	0.007	0.993	0.000
M85.54 Aneurysmal bone cyst (Hand)	0.007	0.993	0.000
M85.53 Aneurysmal bone cyst (Forearm)	0.007	0.993	0.000
M85.52 Aneurysmal bone cyst (Upper arm)	0.007	0.993	0.000
M85.51 Aneurysmal bone cyst (Shoulder region)	0.007	0.993	0.000
M85.50 Aneurysmal bone cyst (Multiple sites)	0.007	0.993	0.000
M85.84 Other specified disorders of bone density and structure (Hand)	0.007	0.993	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.007	0.993	0.000
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.007	0.993	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.007	0.993	0.000
M07.6 Other enteropathic arthropathies	0.007	0.993	0.000
M07.5 Arthropathy in ulcerative colitis	0.007	0.993	0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.007	0.993	0.000
M07.2 Psoriatic spondylitis	0.007	0.993	0.000
M07.1 Arthritis mutilans	0.007	0.993	0.000
M07.0 Distal interphalangeal psoriatic arthropathy	0.007	0.993	0.000
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.007	0.993	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.007	0.993	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.007	0.993	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.007	0.993	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.007	0.993	0.000
M85.04 Fibrous dysplasia (monostotic) (Hand)	0.007	0.993	0.000
M85.03 Fibrous dysplasia (monostotic) (Forearm)	0.007	0.993	0.000
M85.02 Fibrous dysplasia (monostotic) (Upper arm)	0.007	0.993	0.000
M85.01 Fibrous dysplasia (monostotic) (Shoulder region)	0.007	0.993	0.000
M82.1 Osteoporosis in endocrine disorders	0.007	0.993	0.000
M84.07 Malunion of fracture (Ankle and foot)	0.007	0.993	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.007	0.993	0.000
M85.85 Other specified disorders of bone density and structure (Pelvic region and thigh)	0.007	0.993	0.000
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.007	0.993	0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.007	0.993	0.000
M84.29 Delayed union of fracture (Site unspecified)	0.006	0.993	0.000
M84.28 Delayed union of fracture (Other)	0.006	0.993	0.000
M84.27 Delayed union of fracture (Ankle and foot)	0.006	0.993	0.000
M84.26 Delayed union of fracture (Lower leg)	0.006	0.993	0.000
M84.25 Delayed union of fracture (Pelvic region and thigh)	0.006	0.993	0.000
M84.24 Delayed union of fracture (Hand)	0.006	0.993	0.000
M84.23 Delayed union of fracture (Forearm)	0.006	0.993	0.000
M84.22 Delayed union of fracture (Upper arm)	0.006	0.993	0.000
M84.21 Delayed union of fracture (Shoulder region)	0.006	0.993	0.000
M84.20 Delayed union of fracture (Multiple sites)	0.006	0.993	0.000
M84.39 Stress fracture, not elsewhere classified (Site unspecified)	0.006	0.993	0.000
M84.38 Stress fracture, not elsewhere classified (Other)	0.006	0.993	0.000
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.006	0.993	0.000
M84.36 Stress fracture, not elsewhere classified (Lower leg)	0.006	0.993	0.000
M84.35 Stress fracture, not elsewhere classified (Pelvic region and thigh)	0.006	0.993	0.000
M84.34 Stress fracture, not elsewhere classified (Hand)	0.006	0.993	0.000
M84.33 Stress fracture, not elsewhere classified (Forearm)	0.006	0.993	0.000
M84.32 Stress fracture, not elsewhere classified (Upper arm)	0.006	0.993	0.000
M84.31 Stress fracture, not elsewhere classified (Shoulder region)	0.006	0.993	0.000
M84.30 Stress fracture, not elsewhere classified (Multiple sites)	0.006	0.993	0.000
M84.99 Disorder of continuity of bone, unspecified (Site unspecified)	0.006	0.993	0.000
M84.98 Disorder of continuity of bone, unspecified (Other)	0.006	0.993	0.000
M84.97 Disorder of continuity of bone, unspecified (Ankle and foot)	0.006	0.993	0.000
M84.96 Disorder of continuity of bone, unspecified (Lower leg)	0.006	0.993	0.000
M84.95 Disorder of continuity of bone, unspecified (Pelvic region and thigh)	0.006	0.993	0.000
M84.94 Disorder of continuity of bone, unspecified (Hand)	0.006	0.993	0.000
M84.93 Disorder of continuity of bone, unspecified (Forearm)	0.006	0.993	0.000
M84.92 Disorder of continuity of bone, unspecified (Upper arm)	0.006	0.993	0.000
M84.91 Disorder of continuity of bone, unspecified (Shoulder region)	0.006	0.993	0.000
M84.90 Disorder of continuity of bone, unspecified (Multiple sites)	0.006	0.993	0.000
S52.60 Fracture of lower end of both ulna and radius (closed)	0.000	0.993	0.007
M84.89 Other disorders of continuity of bone (Site unspecified)	0.006	0.993	0.000
M84.88 Other disorders of continuity of bone (Other)	0.006	0.993	0.000
M84.86 Other disorders of continuity of bone (Lower leg)	0.006	0.993	0.000
M84.85 Other disorders of continuity of bone (Pelvic region and thigh)	0.006	0.993	0.000
M84.84 Other disorders of continuity of bone (Hand)	0.006	0.993	0.000
M84.83 Other disorders of continuity of bone (Forearm)	0.006	0.993	0.000
M84.82 Other disorders of continuity of bone (Upper arm)	0.006	0.993	0.000
M84.81 Other disorders of continuity of bone (Shoulder region)	0.006	0.993	0.000
M84.80 Other disorders of continuity of bone (Multiple sites)	0.006	0.993	0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.006	0.993	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.006	0.993	0.000
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.006	0.993	0.000
M84.01 Malunion of fracture (Shoulder region)	0.006	0.993	0.000
M84.87 Other disorders of continuity of bone (Ankle and foot)	0.006	0.993	0.000
M10.97 Gout, unspecified (Ankle and foot)	0.006	0.994	0.000
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.000	0.994	0.006
M84.05 Malunion of fracture (Pelvic region and thigh)	0.006	0.994	0.000
Z91.1 Personal history of noncompliance with medical treatment and regimen	0.006	0.994	0.000
M84.06 Malunion of fracture (Lower leg)	0.006	0.994	0.000
I61.6 Intracerebral haemorrhage, multiple localised	0.006	0.994	0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.006	0.994	0.000
I61.8 Other intracerebral haemorrhage	0.006	0.994	0.000
M84.02 Malunion of fracture (Upper arm)	0.006	0.994	0.000
M83.09 Puerperal osteomalacia (Site unspecified)	0.006	0.994	0.000
M83.08 Puerperal osteomalacia (Other)	0.006	0.994	0.000
M83.07 Puerperal osteomalacia (Ankle and foot)	0.006	0.994	0.000
M83.06 Puerperal osteomalacia (Lower leg)	0.006	0.994	0.000
M83.05 Puerperal osteomalacia (Pelvic region and thigh)	0.006	0.994	0.000
M83.04 Puerperal osteomalacia (Hand)	0.006	0.994	0.000
M83.03 Puerperal osteomalacia (Forearm)	0.006	0.994	0.000
M83.02 Puerperal osteomalacia (Upper arm)	0.006	0.994	0.000
M83.01 Puerperal osteomalacia (Shoulder region)	0.006	0.994	0.000
M83.00 Puerperal osteomalacia (Multiple sites)	0.006	0.994	0.000
M83.19 Senile osteomalacia (Site unspecified)	0.006	0.994	0.000
M83.18 Senile osteomalacia (Other)	0.006	0.994	0.000
M83.17 Senile osteomalacia (Ankle and foot)	0.006	0.994	0.000
M83.16 Senile osteomalacia (Lower leg)	0.006	0.994	0.000
M83.15 Senile osteomalacia (Pelvic region and thigh)	0.006	0.994	0.000
M83.14 Senile osteomalacia (Hand)	0.006	0.994	0.000
M83.13 Senile osteomalacia (Forearm)	0.006	0.994	0.000
M83.12 Senile osteomalacia (Upper arm)	0.006	0.994	0.000
M83.11 Senile osteomalacia (Shoulder region)	0.006	0.994	0.000
M83.10 Senile osteomalacia (Multiple sites)	0.006	0.994	0.000
M83.29 Adult osteomalacia due to malabsorption (Site unspecified)	0.006	0.994	0.000
M83.28 Adult osteomalacia due to malabsorption (Other)	0.006	0.994	0.000
M83.27 Adult osteomalacia due to malabsorption (Ankle and foot)	0.006	0.994	0.000
M83.26 Adult osteomalacia due to malabsorption (Lower leg)	0.006	0.994	0.000
M83.25 Adult osteomalacia due to malabsorption (Pelvic region and thigh)	0.006	0.994	0.000
M83.24 Adult osteomalacia due to malabsorption (Hand)	0.006	0.994	0.000
M83.23 Adult osteomalacia due to malabsorption (Forearm)	0.006	0.994	0.000
M83.22 Adult osteomalacia due to malabsorption (Upper arm)	0.006	0.994	0.000
M83.21 Adult osteomalacia due to malabsorption (Shoulder region)	0.006	0.994	0.000
M83.20 Adult osteomalacia due to malabsorption (Multiple sites)	0.006	0.994	0.000
M83.39 Adult osteomalacia due to malnutrition (Site unspecified)	0.006	0.994	0.000
M83.38 Adult osteomalacia due to malnutrition (Other)	0.006	0.994	0.000
M83.37 Adult osteomalacia due to malnutrition (Ankle and foot)	0.006	0.994	0.000
M83.36 Adult osteomalacia due to malnutrition (Lower leg)	0.006	0.994	0.000
M83.35 Adult osteomalacia due to malnutrition (Pelvic region and thigh)	0.006	0.994	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations