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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12693217
log Bayes Factor = 0.00778813
Chromosome 2   position 180,841,914  (GRCh37) Explore rs12693217 on Ensembl!
Variant rs12693217 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
D50.9 Iron deficiency anaemia, unspecified
0.066 0.934 0.000
D50 Iron deficiency anaemia
0.063 0.937 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.059 0.941 0.000
D50-D53 Nutritional anaemias
0.056 0.944 0.000
D51 Vitamin B12 deficiency anaemia
0.051 0.949 0.000
D50.1 Sideropenic dysphagia
0.045 0.954 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.045 0.955 0.000
D52 Folate deficiency anaemia
0.045 0.955 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.042 0.958 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.038 0.962 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.038 0.962 0.000
D50.8 Other iron deficiency anaemias
0.038 0.962 0.000
D52.9 Folate deficiency anaemia, unspecified
0.037 0.962 0.000
D51.2 Transcobalamin II deficiency
0.037 0.963 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.037 0.963 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.037 0.963 0.000
D23.3 Skin of other and unspecified parts of face
0.037 0.963 0.000
D53 Other nutritional anaemias
0.035 0.965 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.000 0.965 0.035
T39.1 4-Aminophenol derivatives
0.000 0.965 0.035
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.000 0.966 0.034
D55-D59 Haemolytic anaemias
0.034 0.966 0.000
D23 Other benign neoplasms of skin
0.033 0.967 0.000
D23.1 Skin of eyelid, including canthus
0.033 0.967 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.000 0.967 0.033
D52.8 Other folate deficiency anaemias
0.032 0.967 0.000
D52.1 Drug-induced folate deficiency anaemia
0.032 0.967 0.000
D52.0 Dietary folate deficiency anaemia
0.032 0.967 0.000
D23.6 Skin of upper limb, including shoulder
0.031 0.969 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.000 0.969 0.031
T46.1 Calcium-channel blockers
0.000 0.969 0.031
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.000 0.970 0.030
D70-D77 Other diseases of blood and blood-forming organs
0.030 0.970 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.030 0.970 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.000 0.971 0.029
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.000 0.971 0.029
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.000 0.971 0.029
D23.5 Skin of trunk
0.028 0.972 0.000
D75 Other diseases of blood and blood-forming organs
0.028 0.972 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.000 0.972 0.028
D75.8 Other specified diseases of blood and blood-forming organs
0.028 0.972 0.000
D58 Other hereditary haemolytic anaemias
0.028 0.972 0.000
D59 Acquired haemolytic anaemia
0.027 0.973 0.000
D60-D64 Aplastic and other anaemias
0.027 0.973 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.000 0.973 0.027
T43.3 Phenothiazine antipsychotics and neuroleptics
0.000 0.973 0.027
D23.2 Skin of ear and external auricular canal
0.027 0.973 0.000
T39.0 Salicylates
0.000 0.973 0.027
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.000 0.973 0.026
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.000 0.974 0.026
T43.2 Other and unspecified antidepressants
0.000 0.974 0.026
T45.5 Anticoagulants
0.000 0.974 0.026
D80-D89 Certain disorders involving the immune mechanism
0.026 0.974 0.000
D68 Other coagulation defects
0.026 0.974 0.000
T42.4 Benzodiazepines
0.000 0.974 0.026
D56 Thalassaemia
0.026 0.974 0.000
D53.8 Other specified nutritional anaemias
0.025 0.974 0.000
D53.2 Scorbutic anaemia
0.025 0.974 0.000
D53.0 Protein deficiency anaemia
0.025 0.974 0.000
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.025 0.974 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.000 0.974 0.025
D57 Sickle-cell disorders
0.025 0.974 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.000 0.975 0.025
T50.9 Other and unspecified drugs, medicaments and biological substances
0.000 0.975 0.025
T45.2 Vitamins, not elsewhere classified
0.000 0.975 0.025
T41 Poisoning by anaesthetics and therapeutic gases
0.000 0.975 0.025
T45.0 Antiallergic and antiemetic drugs
0.000 0.975 0.025
T39.4 Antirheumatics, not elsewhere classified
0.000 0.975 0.024
T39.2 Pyrazolone derivatives
0.000 0.975 0.024
D55 Anaemia due to enzyme disorders
0.024 0.975 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.000 0.976 0.024
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.000 0.976 0.024
T46.8 Antivaricose drugs, including sclerosing agents
0.000 0.976 0.024
T46.7 Peripheral vasodilators
0.000 0.976 0.024
T46.5 Other antihypertensive drugs, not elsewhere classified
0.000 0.976 0.023
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.000 0.977 0.023
T43.6 Psychostimulants with abuse potential
0.000 0.977 0.023
D66 Hereditary factor VIII deficiency
0.023 0.977 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.000 0.977 0.023
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.000 0.977 0.023
D68.9 Coagulation defect, unspecified
0.023 0.977 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.000 0.977 0.023
T36 Poisoning by systemic antibiotics
0.000 0.977 0.023
T45.4 Iron and its compounds
0.000 0.977 0.023
T45.1 Antineoplastic and immunosuppressive drugs
0.000 0.977 0.023
T40.4 Other synthetic narcotics
0.000 0.977 0.023
T45.9 Primarily systemic and haematological agent, unspecified
0.000 0.977 0.023
T45.8 Other primarily systemic and haematological agents
0.000 0.977 0.023
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.000 0.977 0.023
T45.6 Fibrinolysis-affecting drugs
0.000 0.977 0.023
T45.3 Enzymes, not elsewhere classified
0.000 0.977 0.023
D72 Other disorders of white blood cells
0.023 0.977 0.000
D64 Other anaemias
0.023 0.977 0.000
T37.2 Antimalarials and drugs acting on other blood protozoa
0.000 0.978 0.022
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.000 0.978 0.022
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.000 0.978 0.022
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.000 0.978 0.022
D59.1 Other autoimmune haemolytic anaemias
0.022 0.978 0.000
T42.1 Iminostilbenes
0.000 0.978 0.022
D75.0 Familial erythrocytosis
0.022 0.978 0.000
D84 Other immunodeficiencies
0.022 0.978 0.000
D23.9 Skin, unspecified
0.022 0.978 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.000 0.978 0.022
D58.9 Hereditary haemolytic anaemia, unspecified
0.022 0.978 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.000 0.978 0.022
T43.8 Other psychotropic drugs, not elsewhere classified
0.000 0.978 0.022
D74 Methaemoglobinaemia
0.022 0.978 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.022 0.978 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.022 0.978 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.000 0.978 0.022
T40.1 Heroin
0.000 0.978 0.021
D68.5 Primary Thrombophilia
0.021 0.979 0.000
D70 Agranulocytosis
0.021 0.979 0.000
D58.0 Hereditary spherocytosis
0.021 0.979 0.000
R03.1 Nonspecific low blood-pressure reading
0.000 0.979 0.021
T40.2 Other opioids
0.000 0.979 0.021
T42.5 Mixed antiepileptics, not elsewhere classified
0.000 0.979 0.021
T42.2 Succinimides and oxazolidinediones
0.000 0.979 0.021
D23.7 Skin of lower limb, including hip
0.021 0.979 0.000
D58.2 Other haemoglobinopathies
0.021 0.979 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.021 0.979 0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.000 0.979 0.021
T37.5 Antiviral drugs
0.000 0.979 0.021
T37.4 Anthelminthics
0.000 0.979 0.021
T37.3 Other antiprotozoal drugs
0.000 0.979 0.021
T37.1 Antimycobacterial drugs
0.000 0.979 0.021
T37.0 Sulphonamides
0.000 0.979 0.021
D53.9 Nutritional anaemia, unspecified
0.020 0.979 0.000
T50.7 Analeptics and opioid receptor antagonists
0.000 0.979 0.021
T50.5 Appetite depressants
0.000 0.979 0.021
T50.3 Electrolytic, caloric and water-balance agents
0.000 0.979 0.021
T50.0 Mineralocorticoids and their antagonists
0.000 0.979 0.021
D59.4 Other nonautoimmune haemolytic anaemias
0.021 0.979 0.000
T43.9 Psychotropic drug, unspecified
0.000 0.979 0.021
D75.9 Disease of blood and blood-forming organs, unspecified
0.021 0.979 0.000
T42.0 Hydantoin derivatives
0.000 0.979 0.020
D61 Other aplastic anaemias
0.021 0.979 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.020 0.979 0.000
D59.9 Acquired haemolytic anaemia, unspecified
0.020 0.979 0.000
D72.1 Eosinophilia
0.020 0.979 0.000
D67 Hereditary factor IX deficiency
0.020 0.980 0.000
T40.3 Methadone
0.000 0.980 0.020
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.000 0.980 0.020
T40.8 Lysergide [LSD]
0.000 0.980 0.020
T40.7 Cannabis (derivatives)
0.000 0.980 0.020
T40.0 Opium
0.000 0.980 0.020
D57.1 Sickle-cell anaemia without crisis
0.020 0.980 0.000
T48.5 Anti-common-cold drugs
0.000 0.980 0.020
D83 Common variable immunodeficiency
0.020 0.980 0.000
T50.4 Drugs affecting uric acid metabolism
0.000 0.980 0.020
D68.1 Hereditary factor XI deficiency
0.020 0.980 0.000
D58.8 Other specified hereditary haemolytic anaemias
0.020 0.980 0.000
D58.1 Hereditary elliptocytosis
0.020 0.980 0.000
T40.5 Cocaine
0.000 0.980 0.020
D68.4 Acquired coagulation factor deficiency
0.020 0.980 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.000 0.980 0.020
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.000 0.980 0.020
T50.1 Loop [high-ceiling] diuretics
0.000 0.980 0.020
D56.3 Thalassaemia trait
0.020 0.980 0.000
D59.8 Other acquired haemolytic anaemias
0.020 0.980 0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.020 0.980 0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.020 0.980 0.000
D59.3 Haemolytic-uraemic syndrome
0.020 0.980 0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.020 0.980 0.000
T42.3 Barbiturates
0.000 0.980 0.020
T43.0 Tricyclic and tetracyclic antidepressants
0.000 0.980 0.020
D80 Immunodeficiency with predominantly antibody defects
0.020 0.980 0.000
T48.6 Antiasthmatics, not elsewhere classified
0.000 0.980 0.019
T50.8 Diagnostic agents
0.000 0.980 0.019
T43.4 Butyrophenone and thioxanthene neuroleptics
0.000 0.980 0.019
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.019 0.981 0.000
T40.6 Other and unspecified narcotics
0.000 0.981 0.019
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.000 0.981 0.019
D59.0 Drug-induced autoimmune haemolytic anaemia
0.019 0.981 0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.000 0.981 0.019
T48.4 Expectorants
0.000 0.981 0.019
T48.3 Antitussives
0.000 0.981 0.019
T48.2 Other and unspecified agents primarily acting on muscles
0.000 0.981 0.019
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.000 0.981 0.019
T48.0 Oxytocic drugs
0.000 0.981 0.019
T36.8 Other systemic antibiotics
0.000 0.981 0.019
D23.4 Skin of scalp and neck
0.019 0.981 0.000
D56.1 Beta thalassaemia
0.019 0.981 0.000
D81 Combined immunodeficiencies
0.019 0.981 0.000
D62 Acute posthaemorrhagic anaemia
0.019 0.981 0.000
D56.8 Other thalassaemias
0.018 0.981 0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.018 0.981 0.000
D56.2 Delta-beta thalassaemia
0.018 0.981 0.000
D56.0 Alpha thalassaemia
0.018 0.981 0.000
D68.8 Other specified coagulation defects
0.019 0.981 0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.000 0.981 0.018
D57.8 Other sickle-cell disorders
0.018 0.981 0.000
D57.2 Double heterozygous sickling disorders
0.018 0.981 0.000
D57.0 Sickle-cell anaemia with crisis
0.018 0.981 0.000
T49.9 Topical agent, unspecified
0.000 0.982 0.018
T49.8 Other topical agents
0.000 0.982 0.018
T49.7 Dental drugs, topically applied
0.000 0.982 0.018
T49.6 Otorhinolaryngological drugs and preparations
0.000 0.982 0.018
T49.5 Ophthalmological drugs and preparations
0.000 0.982 0.018
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.000 0.982 0.018
T49.3 Emollients, demulcents and protectants
0.000 0.982 0.018
T49.2 Local astringents and local detergents
0.000 0.982 0.018
T49.1 Antipruritics
0.000 0.982 0.018
D68.0 Von Willebrand's disease
0.018 0.982 0.000
D84.9 Immunodeficiency, unspecified
0.018 0.982 0.000
D82 Immunodeficiency associated with other major defects
0.018 0.982 0.000
D56.9 Thalassaemia, unspecified
0.018 0.982 0.000
D64.9 Anaemia, unspecified
0.018 0.982 0.000
D75.2 Essential thrombocytosis
0.018 0.982 0.000
T41.5 Therapeutic gases
0.000 0.982 0.018
T41.4 Anaesthetic, unspecified
0.000 0.982 0.018
T41.3 Local anaesthetics
0.000 0.982 0.018
T41.1 Intravenous anaesthetics
0.000 0.982 0.018
T41.0 Inhaled anaesthetics
0.000 0.982 0.018
D55.9 Anaemia due to enzyme disorder, unspecified
0.018 0.982 0.000
D55.8 Other anaemias due to enzyme disorders
0.018 0.982 0.000
D55.3 Anaemia due to disorders of nucleotide metabolism
0.018 0.982 0.000
D55.2 Anaemia due to disorders of glycolytic enzymes
0.018 0.982 0.000
D55.1 Anaemia due to other disorders of glutathione metabolism
0.018 0.982 0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.018 0.982 0.000
D64.3 Other sideroblastic anaemias
0.018 0.982 0.000
T38.0 Glucocorticoids and synthetic analogues
0.000 0.982 0.017
T38.9 Other and unspecified hormone antagonists
0.000 0.982 0.017
T38.7 Androgens and anabolic congeners
0.000 0.982 0.017
T38.5 Other oestrogens and progestogens
0.000 0.982 0.017
T38.4 Oral contraceptives
0.000 0.982 0.017
T38.2 Antithyroid drugs
0.000 0.982 0.017
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.000 0.982 0.017
T41.2 Other and unspecified general anaesthetics
0.000 0.982 0.017
D75.1 Secondary polycythaemia
0.017 0.983 0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.000 0.983 0.017
D69 Purpura and other haemorrhagic conditions
0.017 0.983 0.000
D57.3 Sickle-cell trait
0.017 0.983 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.000 0.983 0.017
E23 Hypofunction and other disorders of pituitary gland
0.000 0.983 0.017
D84.8 Other specified immunodeficiencies
0.017 0.983 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.017 0.983 0.000
D23.0 Skin of lip
0.017 0.983 0.000
T36.4 Tetracyclines
0.000 0.983 0.017
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.000 0.983 0.017
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.000 0.983 0.017
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.000 0.983 0.017
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.000 0.983 0.017
T44.1 Other parasympathomimetics [cholinergics]
0.000 0.983 0.017
T44.0 Anticholinesterase agents
0.000 0.983 0.017
E23.0 Hypopituitarism
0.000 0.983 0.017
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.000 0.983 0.017
T47.0 Histamine H(2)-receptor antagonists
0.000 0.983 0.017
D64.8 Other specified anaemias
0.017 0.983 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.017 0.983 0.000
D61.9 Aplastic anaemia, unspecified
0.017 0.983 0.000
D68.6 Other Thrombophilia
0.017 0.983 0.000
T36.9 Systemic antibiotic, unspecified
0.000 0.983 0.016
T36.7 Antifungal antibiotics, systemically used
0.000 0.983 0.016
T36.6 Rifamycins
0.000 0.983 0.016
T36.5 Aminoglycosides
0.000 0.983 0.016
T36.2 Chloramphenicol group
0.000 0.983 0.016
T38.1 Thyroid hormones and substitutes
0.000 0.983 0.017
E23.2 Diabetes insipidus
0.000 0.983 0.017
D72.9 Disorder of white blood cells, unspecified
0.016 0.983 0.000
D72.0 Genetic anomalies of leukocytes
0.016 0.983 0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.000 0.984 0.016
D64.4 Congenital dyserythropoietic anaemia
0.016 0.984 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.016 0.984 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.016 0.984 0.000
D64.0 Hereditary sideroblastic anaemia
0.016 0.984 0.000
D84.1 Defects in the complement system
0.016 0.984 0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.000 0.984 0.016
T47.8 Other agents primarily affecting the gastro-intestinal system
0.000 0.984 0.016
T47.7 Emetics
0.000 0.984 0.016
T47.5 Digestants
0.000 0.984 0.016
T47.3 Saline and osmotic laxatives
0.000 0.984 0.016
T38.8 Other and unspecified hormones and their synthetic substitutes
0.000 0.984 0.016
D83.9 Common variable immunodeficiency, unspecified
0.016 0.984 0.000
T47.6 Antidiarrhoeal drugs
0.000 0.984 0.016
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.000 0.984 0.016
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.016 0.984 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.000 0.984 0.016
D74.9 Methaemoglobinaemia, unspecified
0.016 0.984 0.000
D74.8 Other methaemoglobinaemias
0.016 0.984 0.000
D74.0 Congenital methaemoglobinaemia
0.016 0.984 0.000
D60.9 Acquired pure red cell aplasia, unspecified
0.016 0.984 0.000
T47.4 Other laxatives
0.000 0.984 0.016
T47.2 Stimulant laxatives
0.000 0.984 0.016
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension
0.000 0.984 0.016
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.000 0.984 0.015
T36.3 Macrolides
0.000 0.984 0.015
D73 Diseases of spleen
0.015 0.985 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.000 0.985 0.015
D61.0 Constitutional aplastic anaemia
0.015 0.985 0.000
D80.8 Other immunodeficiencies with predominantly antibody defects
0.015 0.985 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.015 0.985 0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.000 0.985 0.015
D61.8 Other specified aplastic anaemias
0.015 0.985 0.000
D61.3 Idiopathic aplastic anaemia
0.015 0.985 0.000
D61.2 Aplastic anaemia due to other external agents
0.015 0.985 0.000
D69.6 Thrombocytopenia, unspecified
0.015 0.985 0.000
D60.8 Other acquired pure red cell aplasias
0.015 0.985 0.000
D60.1 Transient acquired pure red cell aplasia
0.015 0.985 0.000
D60.0 Chronic acquired pure red cell aplasia
0.015 0.985 0.000
D83.8 Other common variable immunodeficiencies
0.015 0.985 0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.015 0.985 0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.015 0.985 0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.015 0.985 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.015 0.985 0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.015 0.985 0.000
M54.59 Low back pain (Site unspecified)
0.000 0.986 0.014
D80.7 Transient hypogammaglobulinaemia of infancy
0.014 0.986 0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.014 0.986 0.000
D80.0 Hereditary hypogammaglobulinaemia
0.014 0.986 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.000 0.986 0.014
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.014 0.986 0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.014 0.986 0.000
E23.6 Other disorders of pituitary gland
0.000 0.986 0.014
D81.9 Combined immunodeficiency, unspecified
0.014 0.986 0.000
D81.8 Other combined immunodeficiencies
0.014 0.986 0.000
D81.7 Major histocompatibility complex class II deficiency
0.014 0.986 0.000
D81.6 Major histocompatibility complex class I deficiency
0.014 0.986 0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.014 0.986 0.000
D81.4 Nezelof's syndrome
0.014 0.986 0.000
D81.3 Adenosine deaminase [ADA] deficiency
0.014 0.986 0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.014 0.986 0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.014 0.986 0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.014 0.986 0.000
M54.5 Low back pain
0.000 0.986 0.014
E23.7 Disorder of pituitary gland, unspecified
0.000 0.986 0.014
D82.1 Di George's syndrome
0.013 0.986 0.000
D69.9 Haemorrhagic condition, unspecified
0.013 0.986 0.000
D69.1 Qualitative platelet defects
0.013 0.986 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.986 0.014
D61.1 Drug-induced aplastic anaemia
0.013 0.987 0.000
D82.9 Immunodeficiency associated with major defect, unspecified
0.013 0.987 0.000
D82.8 Immunodeficiency associated with other specified major defects
0.013 0.987 0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.013 0.987 0.000
D82.2 Immunodeficiency with short-limbed stature
0.013 0.987 0.000
D82.0 Wiskott-Aldrich syndrome
0.013 0.987 0.000
D69.8 Other specified haemorrhagic conditions
0.013 0.987 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.013 0.987 0.000
D89.1 Cryoglobulinaemia
0.013 0.987 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.013 0.987 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.987 0.013
T36.0 Penicillins
0.000 0.987 0.012
D69.4 Other primary thrombocytopenia
0.013 0.987 0.000
E23.1 Drug-induced hypopituitarism
0.000 0.987 0.013
D63 Anaemia in chronic diseases classified elsewhere
0.013 0.987 0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.012 0.987 0.000
D76.2 Haemophagocytic syndrome, infection-associated
0.012 0.987 0.000
D76.1 Haemophagocytic lymphohistiocytosis
0.012 0.987 0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.012 0.987 0.000
M54.55 Low back pain (Thoracolumbar region)
0.000 0.987 0.013
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.012 0.987 0.000
M54.50 Low back pain (Multiple sites in spine)
0.000 0.988 0.012
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.000 0.988 0.012
D73.4 Cyst of spleen
0.012 0.988 0.000
D89.3 Immune reconstitution syndrome
0.012 0.988 0.000
D68.2 Hereditary deficiency of other clotting factors
0.012 0.988 0.000
D73.5 Infarction of spleen
0.012 0.988 0.000
D73.3 Abscess of spleen
0.011 0.988 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.011 0.989 0.000
D73.2 Chronic congestive splenomegaly
0.011 0.989 0.000
E29 Testicular dysfunction
0.000 0.989 0.011
E20 Hypoparathyroidism
0.000 0.989 0.011
E04.1 Non-toxic single thyroid nodule
0.000 0.989 0.011
M54.54 Low back pain-Thoracic
0.000 0.989 0.011
D73.1 Hypersplenism
0.011 0.989 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.011 0.989 0.000
E26 Hyperaldosteronism
0.000 0.989 0.011
D69.5 Secondary thrombocytopenia
0.010 0.989 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.990 0.010
D86 Sarcoidosis
0.010 0.990 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.990 0.010
E25 Adrenogenital disorders
0.000 0.990 0.010
E34 Other endocrine disorders
0.000 0.990 0.010
E24 Cushing's syndrome
0.000 0.990 0.010
D69.0 Allergic purpura
0.010 0.990 0.000
M54.52 Low back pain-Cervical
0.000 0.990 0.010
M54.53 Low back pain-Cervicothoracic
0.000 0.990 0.010
M54.51 Low back pain-Occipit-atl-axl
0.000 0.990 0.010
E20.9 Hypoparathyroidism, unspecified
0.000 0.990 0.010
D73.8 Other diseases of spleen
0.010 0.990 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.990 0.010
E30 Disorders of puberty, not elsewhere classified
0.000 0.990 0.010
E27 Other disorders of adrenal gland
0.000 0.990 0.010
E29.1 Testicular hypofunction
0.000 0.990 0.010
D73.9 Disease of spleen, unspecified
0.010 0.990 0.000
E31 Polyglandular dysfunction
0.000 0.990 0.010
E22 Hyperfunction of pituitary gland
0.000 0.990 0.010
D69.2 Other nonthrombocytopenic purpura
0.009 0.990 0.000
E32 Diseases of thymus
0.000 0.990 0.009
E61.1 Iron deficiency
0.000 0.991 0.009
D63.1 Anaemia in other chronic diseases classified elsewhere
0.009 0.991 0.000
E21.2 Other hyperparathyroidism
0.000 0.991 0.009
D72.8 Other specified disorders of white blood cells
0.009 0.991 0.000
M54.57 Low back pain (Lumbosacral region)
0.000 0.991 0.009
E27.2 Addisonian crisis
0.000 0.991 0.009
E28 Ovarian dysfunction
0.000 0.991 0.009
D89.2 Hypergammaglobulinaemia, unspecified
0.009 0.991 0.000
T93.2 Sequelae of other fractures of lower limb
0.000 0.991 0.009
E26.0 Primary hyperaldosteronism
0.000 0.991 0.009
D86.3 Sarcoidosis of skin
0.008 0.991 0.000
E29.8 Other testicular dysfunction
0.000 0.992 0.008
E29.0 Testicular hyperfunction
0.000 0.992 0.008
E61 Deficiency of other nutrient elements
0.000 0.992 0.008
E20.0 Idiopathic hypoparathyroidism
0.000 0.992 0.008
E55.9 Vitamin D deficiency, unspecified
0.000 0.992 0.008
E29.9 Testicular dysfunction, unspecified
0.000 0.992 0.008
E50-E64 Other nutritional deficiencies
0.000 0.992 0.008
E55 Vitamin D deficiency
0.000 0.992 0.008
E20.8 Other hypoparathyroidism
0.000 0.992 0.008
E20.1 Pseudohypoparathyroidism
0.000 0.992 0.008
D76.3 Other histiocytosis syndromes
0.007 0.992 0.001
M54.17 Radiculopathy (Lumbosacral region)
0.000 0.992 0.008
M54 Dorsalgia
0.000 0.992 0.008
E24.2 Drug-induced Cushing's syndrome
0.000 0.992 0.008
E34.8 Other specified endocrine disorders
0.000 0.992 0.008
E26.8 Other hyperaldosteronism
0.000 0.992 0.008
E26.1 Secondary hyperaldosteronism
0.000 0.992 0.008
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.008 0.992 0.000
D63.8 Anaemia in other chronic diseases classified elsewhere
0.008 0.992 0.000
D86.8 Sarcoidosis of other and combined sites
0.008 0.992 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.992 0.008
E26.9 Hyperaldosteronism, unspecified
0.000 0.992 0.008
E27.1 Primary adrenocortical insufficiency
0.000 0.992 0.008
M54.1 Radiculopathy
0.000 0.992 0.008
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.992 0.008
E27.8 Other specified disorders of adrenal gland
0.000 0.992 0.008
E24.8 Other Cushing's syndrome
0.000 0.992 0.008
E34.9 Endocrine disorder, unspecified
0.000 0.992 0.008
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.992 0.007
E24.0 Pituitary-dependent Cushing's disease
0.000 0.992 0.007
E25.9 Adrenogenital disorder, unspecified
0.000 0.992 0.007
E25.8 Other adrenogenital disorders
0.000 0.992 0.007
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.992 0.007
E24.3 Ectopic ACTH syndrome
0.000 0.992 0.007
E24.1 Nelson's syndrome
0.000 0.992 0.007
E34.5 Androgen resistance syndrome
0.000 0.992 0.007
E34.4 Constitutional tall stature
0.000 0.992 0.007
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.992 0.007
E34.1 Other hypersecretion of intestinal hormones
0.000 0.992 0.007
E21.4 Other specified disorders of parathyroid gland
0.000 0.992 0.007
E28.3 Primary ovarian failure
0.000 0.993 0.007
E30.9 Disorder of puberty, unspecified
0.000 0.993 0.007
E30.8 Other disorders of puberty
0.000 0.993 0.007
E30.1 Precocious puberty
0.000 0.993 0.007
E30.0 Delayed puberty
0.000 0.993 0.007
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.993 0.007
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.993 0.007
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.993 0.007
E27.5 Adrenomedullary hyperfunction
0.000 0.993 0.007
E27.0 Other adrenocortical overactivity
0.000 0.993 0.007
E34.3 Short stature, not elsewhere classified
0.000 0.993 0.007
E34.0 Carcinoid syndrome
0.000 0.993 0.007
M54.8 Other dorsalgia
0.000 0.993 0.007
E31.9 Polyglandular dysfunction, unspecified
0.000 0.993 0.007
E31.8 Other polyglandular dysfunction
0.000 0.993 0.007
E31.1 Polyglandular hyperfunction
0.000 0.993 0.007
E22.8 Other hyperfunction of pituitary gland
0.000 0.993 0.007
M54.4 Lumbago with sciatica
0.000 0.993 0.007
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.993 0.007
E32.1 Abscess of thymus
0.000 0.993 0.007
E32.0 Persistent hyperplasia of thymus
0.000 0.993 0.007
T93 Sequelae of injuries of lower limb
0.000 0.993 0.007
E24.9 Cushing's syndrome, unspecified
0.000 0.993 0.007
E31.0 Autoimmune polyglandular failure
0.000 0.993 0.007
T93.8 Sequelae of other specified injuries of lower limb
0.000 0.993 0.007
E32.9 Disease of thymus, unspecified
0.000 0.993 0.007
E32.8 Other diseases of thymus
0.000 0.993 0.007
M54.12 Radiculopathy (Cervical region)
0.000 0.993 0.007
E28.9 Ovarian dysfunction, unspecified
0.000 0.993 0.006
E28.8 Other ovarian dysfunction
0.000 0.993 0.006
E28.1 Androgen excess
0.000 0.993 0.006
E28.0 Oestrogen excess
0.000 0.993 0.006
D73.0 Hyposplenism
0.006 0.993 0.000
E51 Thiamine deficiency
0.000 0.993 0.007
E58 Dietary calcium deficiency
0.000 0.993 0.007
E22.1 Hyperprolactinaemia
0.000 0.993 0.006
E63 Other nutritional deficiencies
0.000 0.993 0.006
M54.86 Other dorsalgia (Lumbar region)
0.000 0.993 0.006
R73.0 Abnormal glucose tolerance test
0.000 0.993 0.007
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.994 0.006
E56 Other vitamin deficiencies
0.000 0.994 0.006
E27.9 Disorder of adrenal gland, unspecified
0.000 0.994 0.006
M54.49 Lumbago with sciatica (Site unspecified)
0.000 0.994 0.006
E61.9 Deficiency of nutrient element, unspecified
0.000 0.994 0.006
E61.8 Deficiency of other specified nutrient elements
0.000 0.994 0.006
E61.7 Deficiency of multiple nutrient elements
0.000 0.994 0.006
E61.6 Vanadium deficiency
0.000 0.994 0.006
E61.5 Molybdenum deficiency
0.000 0.994 0.006
E61.4 Chromium deficiency
0.000 0.994 0.006
E61.3 Manganese deficiency
0.000 0.994 0.006
E61.0 Copper deficiency
0.000 0.994 0.006
E22.0 Acromegaly and pituitary gigantism
0.000 0.994 0.006
E04 Other non-toxic goitre
0.000 0.994 0.006
T93.0 Sequelae of open wound of lower limb
0.000 0.994 0.006
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.994 0.006
E50 Vitamin A deficiency
0.000 0.994 0.006
E60 Dietary zinc deficiency
0.000 0.994 0.006
E59 Dietary selenium deficiency
0.000 0.994 0.006
E52 Niacin deficiency [pellagra]
0.000 0.994 0.006
M54.14 Radiculopathy (Thoracic region)
0.000 0.994 0.006

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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