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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12813285
log Bayes Factor = 22.3499
Chromosome 12   position 68,206,219  (GRCh37) Explore rs12813285 on Ensembl!
Variant rs12813285 is part of Cluster X0253

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XXI Factors influencing health status and contact with health services
1.000 0.000 0.000
M05-M14 Inflammatory polyarthropathies
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
R50-R69 General symptoms and signs
0.999 0.001 0.000
I30-I52 Other forms of heart disease
0.999 0.001 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.999 0.001 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.998 0.002 0.000
M20-M25 Other joint disorders
0.998 0.002 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.997 0.003 0.000
Z86 Personal history of certain other diseases
0.997 0.003 0.000
I60-I69 Cerebrovascular diseases
0.996 0.004 0.000
Chapter V Mental and behavioural disorders
0.995 0.005 0.000
Chapter II Neoplasms
0.994 0.006 0.000
M06 Other rheumatoid arthritis
0.994 0.006 0.000
Z86.7 Personal history of diseases of the circulatory system
0.989 0.011 0.000
O60-O75 Complications of labour and delivery
0.987 0.013 0.000
M50-M54 Other dorsopathies
0.987 0.013 0.000
F30-F39 Mood [affective] disorders
0.985 0.015 0.000
M06.9 Rheumatoid arthritis, unspecified
0.985 0.015 0.000
M13 Other arthritis
0.984 0.016 0.000
M45-M49 Spondylopathies
0.982 0.018 0.000
I49 Other cardiac arrhythmias
0.982 0.018 0.000
I67 Other cerebrovascular diseases
0.979 0.021 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.973 0.027 0.000
R51 Headache
0.971 0.029 0.000
M13.9 Arthritis, unspecified
0.970 0.030 0.000
M54 Dorsalgia
0.969 0.031 0.000
M22 Disorders of patella
0.968 0.032 0.000
M13.99 Arthritis, unspecified (Site unspecified)
0.968 0.032 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.966 0.034 0.000
M47 Spondylosis
0.963 0.037 0.000
I45 Other conduction disorders
0.961 0.039 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.960 0.040 0.000
R63 Symptoms and signs concerning food and fluid intake
0.958 0.042 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.957 0.043 0.000
M54.5 Low back pain
0.956 0.044 0.000
M35 Other systemic involvement of connective tissue
0.955 0.045 0.000
O00-O08 Pregnancy with abortive outcome
0.954 0.046 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.954 0.046 0.000
Z51 Other medical care
0.953 0.047 0.000
M23 Internal derangement of knee
0.952 0.048 0.000
Z86.1 Personal history of infectious and parasitic diseases
0.951 0.049 0.000
I35 Nonrheumatic aortic valve disorders
0.950 0.050 0.000
F32 Depressive episode
0.948 0.052 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.947 0.053 0.000
Z96 Presence of other functional implants
0.947 0.053 0.000
Chapter VI Diseases of the nervous system
0.945 0.055 0.000
I67.8 Other specified cerebrovascular diseases
0.942 0.058 0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system
0.940 0.060 0.000
Z51.0 Radiotherapy session
0.940 0.060 0.000
O70 Perineal laceration during delivery
0.939 0.061 0.000
I45.1 Other and unspecified right bundle-branch block
0.935 0.065 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.933 0.067 0.000
R63.4 Abnormal weight loss
0.932 0.068 0.000
M80-M85 Disorders of bone density and structure
0.932 0.068 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.931 0.069 0.000
R42 Dizziness and giddiness
0.926 0.074 0.000
O72 Postpartum haemorrhage
0.925 0.075 0.000
M22.4 Chondromalacia patellae
0.925 0.075 0.000
Z96.0 Presence of urogenital implants
0.921 0.079 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.920 0.080 0.000
R60 Oedema, not elsewhere classified
0.918 0.082 0.000
C64-C68 Malignant neoplasms of urinary tract
0.918 0.082 0.000
F32.9 Depressive episode, unspecified
0.917 0.083 0.000
M47.8 Other spondylosis
0.913 0.087 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.911 0.089 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.910 0.090 0.000
M05 Seropositive rheumatoid arthritis
0.910 0.090 0.000
M70-M79 Other soft tissue disorders
0.909 0.091 0.000
O70.0 First degree perineal laceration during delivery
0.903 0.097 0.000
S20-S29 Injuries to the thorax
0.900 0.100 0.000
R52 Pain, not elsewhere classified
0.898 0.102 0.000
Z86.0 Personal history of other neoplasms
0.897 0.103 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.895 0.105 0.000
M23.8 Other internal derangements of knee
0.890 0.110 0.000
I49.8 Other specified cardiac arrhythmias
0.889 0.111 0.000
M35.3 Polymyalgia rheumatica
0.887 0.113 0.000
S70-S79 Injuries to the hip and thigh
0.884 0.116 0.000
Chapter XX External causes of morbidity and mortality
0.883 0.117 0.000
C51-C58 Malignant neoplasms of female genital organs
0.878 0.122 0.000
M06.0 Seronegative rheumatoid arthritis
0.876 0.124 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.873 0.127 0.000
O62 Abnormalities of forces of labour
0.872 0.128 0.000
I49.0 Ventricular fibrillation and flutter
0.871 0.129 0.000
Z92 Personal history of medical treatment
0.870 0.130 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.870 0.130 0.000
M48 Other spondylopathies
0.869 0.131 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.866 0.134 0.000
R53 Malaise and fatigue
0.864 0.136 0.000
F33 Recurrent depressive disorder
0.864 0.136 0.000
M07 Psoriatic and enteropathic arthropathies
0.864 0.136 0.000
M54.57 Low back pain (Lumbosacral region)
0.863 0.137 0.000
O02 Other abnormal products of conception
0.861 0.139 0.000
M47.9 Spondylosis, unspecified
0.861 0.139 0.000
I67.1 Cerebral aneurysm, nonruptured
0.859 0.141 0.000
S00-S09 Injuries to the head
0.857 0.143 0.000
I35.0 Aortic (valve) stenosis
0.856 0.144 0.000
Z40 Prophylactic surgery
0.856 0.144 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.854 0.146 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.853 0.147 0.000
I33 Acute and subacute endocarditis
0.852 0.147 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.851 0.149 0.000
I63 Cerebral infarction
0.851 0.149 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.850 0.150 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.848 0.152 0.000
R60.0 Localised oedema
0.847 0.153 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.845 0.155 0.000
M51 Other intervertebral disk disorders
0.845 0.155 0.000
M81 Osteoporosis without pathological fracture
0.843 0.157 0.000
R80 Isolated proteinuria
0.843 0.157 0.000
I46 Cardiac arrest
0.842 0.158 0.000
Z86.6 Personal history of diseases of the nervous system and sense organs
0.842 0.158 0.000
Z82.0 Family history of epilepsy and other diseases of the nervous system
0.841 0.159 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.839 0.161 0.000
C15-C26 Malignant neoplasms of digestive organs
0.838 0.162 0.000
I50 Heart failure
0.838 0.162 0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)
0.836 0.164 0.000
M24 Other specific joint derangements
0.835 0.165 0.000
Z51.8 Other specified medical care
0.831 0.169 0.000
R52.1 Chronic intractable pain
0.831 0.169 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.829 0.171 0.000
O72.1 Other immediate postpartum haemorrhage
0.829 0.171 0.000
M54.56 Low back pain (Lumbar region)
0.828 0.172 0.000
R87 Abnormal findings in specimens from female genital organs
0.827 0.173 0.000
Z86.4 Personal history of psychoactive substance abuse
0.825 0.175 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.825 0.175 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.825 0.175 0.000
R47-R49 Symptoms and signs involving speech and voice
0.825 0.175 0.000
Z63 Other problems related to primary support group, including family circumstances
0.825 0.175 0.000
G90-G99 Other disorders of the nervous system
0.822 0.178 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.822 0.178 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.821 0.179 0.000
M54.59 Low back pain (Site unspecified)
0.820 0.180 0.000
Z50 Care involving use of rehabilitation procedures
0.818 0.182 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.818 0.182 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.817 0.183 0.000
S40-S49 Injuries to the shoulder and upper arm
0.817 0.183 0.000
I60 Subarachnoid haemorrhage
0.817 0.183 0.000
O72.2 Delayed and secondary postpartum haemorrhage
0.817 0.183 0.000
M47.82 Other spondylosis (Cervical region)
0.817 0.183 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.815 0.185 0.000
F31 Bipolar affective disorder
0.814 0.186 0.000
M22.2 Patellofemoral disorders
0.814 0.186 0.000
I69 Sequelae of cerebrovascular disease
0.814 0.186 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.812 0.188 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.812 0.188 0.000
D00-D09 In situ neoplasms
0.811 0.188 0.000
O04 Medical abortion
0.811 0.189 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.810 0.190 0.000
R50 Fever of unknown origin
0.808 0.192 0.000
G20-G26 Extrapyramidal and movement disorders
0.808 0.192 0.000
S50-S59 Injuries to the elbow and forearm
0.808 0.192 0.000
R61 Hyperhidrosis
0.807 0.193 0.000
Z51.9 Medical care, unspecified
0.807 0.193 0.000
Z60 Problems related to social environment
0.806 0.194 0.000
I49.3 Ventricular premature depolarisation
0.801 0.199 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.801 0.199 0.000
I67.9 Cerebrovascular disease, unspecified
0.800 0.200 0.000
C60-C63 Malignant neoplasms of male genital organs
0.799 0.201 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.799 0.201 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.799 0.201 0.000
O03 Spontaneous abortion
0.795 0.205 0.000
I62 Other nontraumatic intracranial haemorrhage
0.795 0.205 0.000
O02.1 Missed abortion
0.795 0.205 0.000
F30 Manic episode
0.792 0.208 0.000
T39.0 Salicylates
0.792 0.208 0.000
C67 Malignant neoplasm of bladder
0.792 0.208 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.789 0.211 0.000
O62.2 Other uterine inertia
0.789 0.211 0.000
R82 Other abnormal findings in urine
0.788 0.212 0.000
M23.4 Loose body in knee
0.788 0.212 0.000
S90-S99 Injuries to the ankle and foot
0.787 0.213 0.000
T66-T78 Other and unspecified effects of external causes
0.787 0.213 0.000
O71 Other obstetric trauma
0.787 0.213 0.000
M35.0 Sicca syndrome [Sjogren]
0.787 0.213 0.000
M47.89 Other spondylosis (Site unspecified)
0.786 0.214 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.785 0.215 0.000
I49.4 Other and unspecified premature depolarisation
0.785 0.215 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.784 0.216 0.000
Z40.0 Prophylactic surgery for risk-factors related to malignant neoplasms
0.781 0.219 0.000
Z49 Care involving dialysis
0.781 0.219 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.781 0.219 0.000
Z92.4 Personal history of major surgery, not elsewhere classified
0.780 0.220 0.000
R63.1 Polydipsia
0.779 0.221 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.779 0.221 0.000
M47.1 Other spondylosis with myelopathy
0.777 0.223 0.000
C88 Malignant immunoproliferative diseases
0.777 0.223 0.000
O70.2 Third degree perineal laceration during delivery
0.777 0.223 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.776 0.224 0.000
I61 Intracerebral haemorrhage
0.776 0.224 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.776 0.224 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.774 0.226 0.000
I35.8 Other aortic valve disorders
0.774 0.226 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.774 0.226 0.000
Z50.1 Other physical therapy
0.773 0.227 0.000
M54.2 Cervicalgia
0.771 0.229 0.000
M40-M43 Deforming dorsopathies
0.771 0.229 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.771 0.229 0.000
F33.9 Recurrent depressive disorder, unspecified
0.769 0.231 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.768 0.232 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.767 0.233 0.000
M07.3 Other psoriatic arthropathies
0.766 0.234 0.000
R87.6 Abnormal cytological findings
0.766 0.234 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.764 0.236 0.000
I49.9 Cardiac arrhythmia, unspecified
0.764 0.236 0.000
M35.7 Hypermobility syndrome
0.763 0.237 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.762 0.238 0.000
S10-S19 Injuries to the neck
0.761 0.239 0.000
M15-M19 Arthrosis
0.761 0.239 0.000
I50.1 Left ventricular failure
0.760 0.240 0.000
M13.0 Polyarthritis, unspecified
0.760 0.240 0.000
T39.1 4-Aminophenol derivatives
0.760 0.240 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.759 0.241 0.000
M54.4 Lumbago with sciatica
0.758 0.242 0.000
M79.8 Other specified soft tissue disorders
0.757 0.243 0.000
Y40 Systemic antibiotics
0.756 0.244 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.754 0.246 0.000
M84 Disorders of continuity of bone
0.753 0.246 0.000
Z89 Acquired absence of limb
0.753 0.247 0.000
R56 Convulsions, not elsewhere classified
0.750 0.250 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.749 0.250 0.000
M79.7 Fibromyalgia
0.749 0.251 0.000
I33.0 Acute and subacute infective endocarditis
0.747 0.253 0.000
M48.0 Spinal stenosis
0.747 0.253 0.000
C56 Malignant neoplasm of ovary
0.747 0.253 0.000
Z50.9 Care involving use of rehabilitation procedure, unspecified
0.747 0.253 0.000
M54.50 Low back pain (Multiple sites in spine)
0.747 0.253 0.000
M81.9 Osteoporosis, unspecified
0.746 0.254 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.746 0.254 0.000
M54.1 Radiculopathy
0.745 0.255 0.000
I37 Pulmonary valve disorders
0.743 0.257 0.000
G37 Other demyelinating diseases of central nervous system
0.743 0.257 0.000
F32.2 Severe depressive episode without psychotic symptoms
0.743 0.257 0.000
Z96.8 Presence of other specified functional implants
0.743 0.257 0.000
Z33 Pregnant state, incidental
0.742 0.258 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.742 0.258 0.000
Z51.2 Other chemotherapy
0.742 0.258 0.000
G70-G73 Diseases of myoneural junction and muscle
0.742 0.258 0.000
Z92.1 Personal history of long-term (current) use of anticoagulants
0.741 0.259 0.000
R47 Speech disturbances, not elsewhere classified
0.740 0.260 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.740 0.260 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.740 0.260 0.000
O61 Failed induction of labour
0.739 0.260 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.739 0.261 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.739 0.261 0.000
F80-F89 Disorders of psychological development
0.739 0.261 0.000
I30 Acute pericarditis
0.739 0.261 0.000
R60.1 Generalised oedema
0.738 0.262 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.738 0.262 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.738 0.262 0.000
S70 Superficial injury of hip and thigh
0.738 0.262 0.000
S72 Fracture of femur
0.736 0.264 0.000
I49.5 Sick sinus syndrome
0.735 0.265 0.000
D04 Carcinoma in situ of skin
0.734 0.266 0.000
I46.0 Cardiac arrest with successful resuscitation
0.734 0.266 0.000
I31 Other diseases of pericardium
0.732 0.268 0.000
M91-M94 Chondropathies
0.732 0.268 0.000
M22.8 Other disorders of patella
0.732 0.268 0.000
S27 Injury of other and unspecified intrathoracic organs
0.732 0.268 0.000
T91 Sequelae of injuries of neck and trunk
0.731 0.269 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.731 0.269 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.730 0.270 0.000
Z64 Problems related to certain psychosocial circumstances
0.730 0.270 0.000
M47.87 Other spondylosis (Lumbosacral region)
0.730 0.270 0.000
S00 Superficial injury of head
0.730 0.270 0.000
C18 Malignant neoplasm of colon
0.729 0.271 0.000
F32.1 Moderate depressive episode
0.729 0.271 0.000
M77 Other enthesopathies
0.728 0.272 0.000
R68 Other general symptoms and signs
0.728 0.272 0.000
F60-F69 Disorders of adult personality and behaviour
0.728 0.272 0.000
Z96.7 Presence of other bone and tendon implants
0.728 0.272 0.000
M21 Other acquired deformities of limbs
0.726 0.273 0.000
I42 Cardiomyopathy
0.726 0.273 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.726 0.274 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.725 0.274 0.000
M31 Other necrotising vasculopathies
0.724 0.276 0.000
M65-M68 Disorders of synovium and tendon
0.724 0.276 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.723 0.277 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.722 0.278 0.000
R69 Unknown and unspecified causes of morbidity
0.722 0.278 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.721 0.279 0.000
M00-M03 Infectious arthropathies
0.720 0.280 0.000
C90.0 Multiple myeloma
0.720 0.280 0.000
R86 Abnormal findings in specimens from male genital organs
0.719 0.281 0.000
I63.8 Other cerebral infarction
0.718 0.282 0.000
Z51.5 Palliative care
0.718 0.282 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.717 0.283 0.000
M14 Arthropathies in other diseases classified elsewhere
0.717 0.283 0.000
M12 Other specific arthropathies
0.717 0.283 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.717 0.283 0.000
M08 Juvenile arthritis
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.716 0.283 0.000
R62 Lack of expected normal physiological development
0.716 0.283 0.000
R57 Shock, not elsewhere classified
0.716 0.283 0.000
R64 Cachexia
0.716 0.283 0.000
R58 Haemorrhage, not elsewhere classified
0.716 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.716 0.283 0.000
I48 Atrial fibrillation and flutter
0.716 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.716 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.716 0.283 0.000
I40 Acute myocarditis
0.716 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.716 0.283 0.000
I36 Nonrheumatic tricuspid valve disorders
0.716 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.716 0.283 0.000
T33-T35 Frostbite
0.716 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.284 0.000
T00-T07 Injuries involving multiple body regions
0.716 0.284 0.000
O85-O92 Complications predominantly related to the puerperium
0.715 0.284 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.715 0.284 0.000
M34 Systemic sclerosis
0.715 0.284 0.000
M33 Dermatopolymyositis
0.715 0.284 0.000
M32 Systemic lupus erythematosus
0.715 0.284 0.000
M30 Polyarteritis nodosa and related conditions
0.715 0.284 0.000
S06 Intracranial injury
0.715 0.285 0.000
Z84 Family history of other conditions
0.715 0.285 0.000
Z81 Family history of mental and behavioural disorders
0.715 0.285 0.000
O03.9 Complete or unspecified, without complication
0.715 0.285 0.000
Z60.2 Living alone
0.715 0.285 0.000
Z39 Postpartum care and examination
0.714 0.285 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.714 0.286 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.714 0.286 0.000
O80-O84 Delivery
0.713 0.286 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.713 0.287 0.000
F70-F79 Mental retardation
0.713 0.287 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.713 0.287 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.713 0.287 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.713 0.287 0.000
M06.8 Other specified rheumatoid arthritis
0.713 0.287 0.000
M06.4 Inflammatory polyarthropathy
0.713 0.287 0.000
M06.3 Rheumatoid nodule
0.713 0.287 0.000
M06.2 Rheumatoid bursitis
0.713 0.287 0.000
M06.1 Adult-onset Still's disease
0.713 0.287 0.000
Z83 Family history of other specific disorders
0.712 0.288 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.711 0.289 0.000
M50 Cervical disk disorders
0.711 0.289 0.000
M23.5 Chronic instability of knee
0.711 0.289 0.000
F52 Sexual dysfunction, not caused by organic disorder or disease
0.710 0.289 0.000
C01 Malignant neoplasm of base of tongue
0.710 0.290 0.000
C92 Myeloid leukaemia
0.709 0.290 0.000
C66 Malignant neoplasm of ureter
0.709 0.291 0.000
M79.0 Rheumatism, unspecified
0.709 0.291 0.000
O04.9 Complete or unspecified, without complication
0.709 0.291 0.000
M13.93 Arthritis, unspecified (Forearm)
0.708 0.292 0.000
O74 Complications of anaesthesia during labour and delivery
0.708 0.292 0.000
O73 Retained placenta and membranes, without haemorrhage
0.708 0.292 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.708 0.292 0.000
O60 Preterm delivery
0.708 0.292 0.000
M53 Other dorsopathies, not elsewhere classified
0.708 0.292 0.000
M80 Osteoporosis with pathological fracture
0.707 0.293 0.000
F38 Other mood [affective] disorders
0.706 0.293 0.000
F34 Persistent mood [affective] disorders
0.706 0.293 0.000
F39 Unspecified mood [affective] disorder
0.706 0.293 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.706 0.294 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.706 0.294 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.706 0.294 0.000
O70.9 Perineal laceration during delivery, unspecified
0.706 0.294 0.000
M13.8 Other specified arthritis
0.706 0.294 0.000
M13.1 Monoarthritis, not elsewhere classified
0.706 0.294 0.000
R54 Senility
0.706 0.294 0.000
I45.6 Preexcitation syndrome
0.705 0.295 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.705 0.295 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.705 0.295 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.704 0.296 0.000
M49 Spondylopathies in diseases classified elsewhere
0.704 0.296 0.000
I49.2 Junctional premature depolarisation
0.704 0.296 0.000
I49.1 Atrial premature depolarisation
0.704 0.296 0.000
I35.1 Aortic (valve) insufficiency
0.704 0.296 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.704 0.296 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.703 0.297 0.000
C73 Malignant neoplasm of thyroid gland
0.703 0.297 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.702 0.298 0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
0.702 0.298 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.702 0.298 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.702 0.298 0.000
I67.5 Moyamoya disease
0.702 0.298 0.000
I67.4 Hypertensive encephalopathy
0.702 0.298 0.000
I67.3 Progressive vascular leukoencephalopathy
0.702 0.298 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.702 0.298 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.702 0.298 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.701 0.299 0.000
Z45 Adjustment and management of implanted device
0.700 0.300 0.000
M23.80 Other internal derangements of knee (Multiple sites)
0.700 0.300 0.000
G25 Other extrapyramidal and movement disorders
0.699 0.301 0.000
T79-T79 Certain early complications of trauma
0.698 0.302 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.698 0.302 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.697 0.303 0.000
C95 Leukaemia of unspecified cell type
0.697 0.303 0.000
C94 Other leukaemias of specified cell type
0.697 0.303 0.000
C93 Monocytic leukaemia
0.697 0.303 0.000
C86 Other specified types of T/NK-cell lymphoma
0.697 0.303 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.697 0.303 0.000
Z31 Procreative management
0.697 0.303 0.000
M81.99 Osteoporosis, unspecified (Site unspecified)
0.697 0.303 0.000
G35 Multiple sclerosis
0.697 0.303 0.000
M51.4 Schmorl's nodes
0.696 0.303 0.000
C57 Malignant neoplasm of other and unspecified female genital organs
0.696 0.303 0.000
M13.92 Arthritis, unspecified (Upper arm)
0.696 0.304 0.000
X10-X19 Contact with heat and hot substances
0.695 0.305 0.000
M54.8 Other dorsalgia
0.695 0.305 0.000
M54.0 Panniculitis affecting regions of neck and back
0.695 0.305 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.695 0.305 0.000
S80-S89 Injuries to the knee and lower leg
0.694 0.306 0.000
M22.1 Recurrent subluxation of patella
0.694 0.306 0.000
M22.9 Disorder of patella, unspecified
0.694 0.306 0.000
M22.3 Other derangements of patella
0.694 0.306 0.000
M22.0 Recurrent dislocation of patella
0.694 0.306 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.694 0.306 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.694 0.306 0.000
L20-L30 Dermatitis and eczema
0.694 0.306 0.000
R30-R39 Symptoms and signs involving the urinary system
0.693 0.307 0.000
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified
0.692 0.307 0.000
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities
0.692 0.307 0.000
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue
0.692 0.307 0.000
Z82.5 Family history of asthma and other chronic lower respiratory diseases
0.692 0.307 0.000
Z82.2 Family history of deafness and hearing loss
0.692 0.307 0.000
Z82.1 Family history of blindness and visual loss
0.692 0.307 0.000
Z96.6 Presence of orthopaedic joint implants
0.692 0.308 0.000
M71 Other bursopathies
0.691 0.309 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.690 0.309 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.690 0.310 0.000
C81 Hodgkin's disease
0.690 0.310 0.000
Z86.2 Personal history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.689 0.311 0.000
I45.8 Other specified conduction disorders
0.689 0.311 0.000
I45.5 Other specified heart block
0.689 0.311 0.000
I45.4 Nonspecific intraventricular block
0.689 0.311 0.000
I45.3 Trifascicular block
0.689 0.311 0.000
I45.2 Bifascicular block
0.689 0.311 0.000
I45.0 Right fascicular block
0.689 0.311 0.000
Z54 Convalescence
0.688 0.312 0.000
Z44 Fitting and adjustment of external prosthetic device
0.688 0.312 0.000
F99-F99 Unspecified mental disorder
0.688 0.312 0.000
S22.2 Fracture of sternum
0.687 0.313 0.000
M81.0 Postmenopausal osteoporosis
0.687 0.313 0.000
R50.8 Other specified fever
0.687 0.313 0.000
R63.6 Insufficient intake of food and water due to self neglect
0.686 0.313 0.000
R63.5 Abnormal weight gain
0.686 0.313 0.000
R63.3 Feeding difficulties and mismanagement
0.686 0.313 0.000
R63.2 Polyphagia
0.686 0.313 0.000
Z63.8 Other specified problems related to primary support group
0.686 0.314 0.000
R46 Symptoms and signs involving appearance and behaviour
0.686 0.314 0.000
R43 Disturbances of smell and taste
0.686 0.314 0.000
M54.55 Low back pain (Thoracolumbar region)
0.685 0.315 0.000
M54.54 Low back pain-Thoracic
0.685 0.315 0.000
M54.53 Low back pain-Cervicothoracic
0.685 0.315 0.000
M54.52 Low back pain-Cervical
0.685 0.315 0.000
M54.51 Low back pain-Occipit-atl-axl
0.685 0.315 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.685 0.315 0.000
M35.8 Other specified systemic involvement of connective tissue
0.685 0.315 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.685 0.315 0.000
M35.5 Multifocal fibrosclerosis
0.685 0.315 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.685 0.315 0.000
M35.2 Behcet's disease
0.685 0.315 0.000
M35.1 Other overlap syndromes
0.685 0.315 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.685 0.315 0.000
O08 Complications following abortion and ectopic and molar pregnancy
0.684 0.316 0.000
O07 Failed attempted abortion
0.684 0.316 0.000
O06 Unspecified abortion
0.684 0.316 0.000
O05 Other abortion
0.684 0.316 0.000
O01 Hydatidiform mole
0.684 0.316 0.000
M54.6 Pain in thoracic spine
0.684 0.316 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.683 0.317 0.000
Z51.6 Desensitisation to allergens
0.683 0.317 0.000
M23.9 Internal derangement of knee, unspecified
0.683 0.317 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.683 0.317 0.000
M23.1 Discoid meniscus (congenital)
0.683 0.317 0.000
M23.0 Cystic meniscus
0.683 0.317 0.000
D45 Polycythaemia vera
0.682 0.318 0.000
M85 Other disorders of bone density and structure
0.681 0.318 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.681 0.319 0.000
C61 Malignant neoplasm of prostate
0.681 0.319 0.000
F32.0 Mild depressive episode
0.681 0.319 0.000
F32.8 Other depressive episodes
0.680 0.320 0.000
I44 Atrioventricular and left bundle-branch block
0.680 0.320 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.679 0.321 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.679 0.321 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.679 0.321 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.679 0.321 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.679 0.321 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.679 0.321 0.000
T36 Poisoning by systemic antibiotics
0.679 0.321 0.000
Z96.9 Presence of functional implant, unspecified
0.679 0.321 0.000
Z96.5 Presence of tooth-root and mandibular implants
0.679 0.321 0.000
Z96.4 Presence of endocrine implants
0.679 0.321 0.000
Z96.3 Presence of artificial larynx
0.679 0.321 0.000
Z96.2 Presence of otological and audiological implants
0.679 0.321 0.000
R41.0 Disorientation, unspecified
0.678 0.322 0.000
W00-W19 Falls
0.678 0.322 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.678 0.322 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.678 0.322 0.000
L40-L45 Papulosquamous disorders
0.678 0.322 0.000
M13.98 Arthritis, unspecified (Other)
0.677 0.323 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.676 0.324 0.000
Z92.0 Personal history of contraception
0.676 0.324 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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