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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12867435
log Bayes Factor = 19.0079
Chromosome 13   position 76,828,392  (GRCh37) Explore rs12867435 on Ensembl!
Variant rs12867435 is part of Cluster X0033

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
Chapter XV Pregnancy, childbirth and the puerperium
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
0.999 0.001 0.000
O60-O75 Complications of labour and delivery
0.999 0.001 0.000
Chapter VI Diseases of the nervous system
0.998 0.002 0.000
I20-I25 Ischaemic heart diseases
0.995 0.005 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.995 0.005 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.994 0.006 0.000
C79 Secondary malignant neoplasm of other sites
0.992 0.008 0.000
I10-I15 Hypertensive diseases
0.990 0.010 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.989 0.011 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.987 0.013 0.000
D50-D53 Nutritional anaemias
0.985 0.015 0.000
G40-G47 Episodic and paroxysmal disorders
0.984 0.016 0.000
R50-R69 General symptoms and signs
0.981 0.019 0.000
R53 Malaise and fatigue
0.981 0.019 0.000
I25 Chronic ischaemic heart disease
0.979 0.021 0.000
I10 Essential (primary) hypertension
0.978 0.022 0.000
D70 Agranulocytosis
0.977 0.023 0.000
Chapter XX External causes of morbidity and mortality
0.975 0.025 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.973 0.027 0.000
G47 Sleep disorders
0.973 0.027 0.000
I25.2 Old myocardial infarction
0.970 0.030 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.970 0.030 0.000
G47.3 Sleep apnoea
0.962 0.038 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.959 0.041 0.000
C77.3 Axillary and upper limb lymph nodes
0.954 0.046 0.000
D60-D64 Aplastic and other anaemias
0.953 0.047 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.943 0.057 0.000
E10-E14 Diabetes mellitus
0.938 0.062 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.932 0.068 0.000
S80-S89 Injuries to the knee and lower leg
0.931 0.069 0.000
Chapter XXI Factors influencing health status and contact with health services
0.920 0.080 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.918 0.082 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.914 0.086 0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly
0.914 0.086 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.913 0.087 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.913 0.087 0.000
D51 Vitamin B12 deficiency anaemia
0.913 0.087 0.000
I24 Other acute ischaemic heart diseases
0.912 0.088 0.000
C50-C50 Malignant neoplasm of breast
0.908 0.092 0.000
O72 Postpartum haemorrhage
0.908 0.092 0.000
D50 Iron deficiency anaemia
0.906 0.094 0.000
G90-G99 Other disorders of the nervous system
0.905 0.095 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.890 0.110 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.886 0.114 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.882 0.118 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.882 0.118 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.881 0.119 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.876 0.124 0.000
Z12 Special screening examination for neoplasms
0.875 0.125 0.000
S82 Fracture of lower leg, including ankle
0.871 0.129 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.871 0.129 0.000
Y95 Nosocomial condition
0.871 0.129 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.870 0.130 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.870 0.130 0.000
C51-C58 Malignant neoplasms of female genital organs
0.866 0.134 0.000
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis
0.862 0.138 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.861 0.139 0.000
E11 Non-insulin-dependent diabetes mellitus
0.856 0.144 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.854 0.146 0.000
I12 Hypertensive renal disease
0.854 0.146 0.000
R60 Oedema, not elsewhere classified
0.850 0.150 0.000
E10 Insulin-dependent diabetes mellitus
0.849 0.151 0.000
Z12.1 Special screening examination for neoplasm of intestinal tract
0.849 0.151 0.000
D00-D09 In situ neoplasms
0.849 0.151 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.847 0.153 0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid
0.846 0.154 0.000
E70-E90 Metabolic disorders
0.845 0.155 0.000
D50.8 Other iron deficiency anaemias
0.844 0.156 0.000
Y43 Primarily systemic agents
0.843 0.157 0.000
C50 Malignant neoplasm of breast
0.842 0.158 0.000
Chapter VII Diseases of the eye and adnexa
0.842 0.158 0.000
R18 Ascites
0.841 0.159 0.000
D64 Other anaemias
0.840 0.160 0.000
R47-R49 Symptoms and signs involving speech and voice
0.838 0.162 0.000
Chapter XIV Diseases of the genitourinary system
0.838 0.162 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.838 0.162 0.000
D52 Folate deficiency anaemia
0.838 0.162 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.837 0.163 0.000
C77.2 Intra-abdominal lymph nodes
0.836 0.164 0.000
O42 Premature rupture of membranes
0.834 0.166 0.000
O72.1 Other immediate postpartum haemorrhage
0.833 0.167 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.830 0.170 0.000
S20-S29 Injuries to the thorax
0.828 0.172 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.828 0.172 0.000
O70 Perineal laceration during delivery
0.824 0.176 0.000
E20-E35 Disorders of other endocrine glands
0.820 0.180 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.820 0.180 0.000
S90-S99 Injuries to the ankle and foot
0.819 0.181 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.817 0.183 0.000
M05-M14 Inflammatory polyarthropathies
0.809 0.191 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.809 0.191 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.807 0.193 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.806 0.194 0.000
C80 Malignant neoplasm without specification of site
0.806 0.194 0.000
E50-E64 Other nutritional deficiencies
0.804 0.196 0.000
N60-N64 Disorders of breast
0.804 0.196 0.000
G43 Migraine
0.804 0.196 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.802 0.198 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.802 0.198 0.000
E83 Disorders of mineral metabolism
0.802 0.198 0.000
C77.1 Intrathoracic lymph nodes
0.801 0.199 0.000
T93 Sequelae of injuries of lower limb
0.800 0.199 0.000
R12 Heartburn
0.800 0.200 0.000
E11.3 With ophthalmic complications
0.794 0.206 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.793 0.206 0.000
R14 Flatulence and related conditions
0.792 0.208 0.000
R00 Abnormalities of heart beat
0.789 0.211 0.000
C77.5 Intrapelvic lymph nodes
0.787 0.213 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.785 0.215 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.784 0.216 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.783 0.217 0.000
S81 Open wound of lower leg
0.781 0.219 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.780 0.220 0.000
R05 Cough
0.777 0.223 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.777 0.223 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.776 0.224 0.000
M70-M79 Other soft tissue disorders
0.775 0.225 0.000
Z01.8 Other specified special examinations
0.775 0.225 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.774 0.226 0.000
I20 Angina pectoris
0.773 0.227 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.769 0.231 0.000
S70-S79 Injuries to the hip and thigh
0.768 0.232 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.765 0.235 0.000
C77.8 Lymph nodes of multiple regions
0.764 0.236 0.000
G62 Other polyneuropathies
0.763 0.237 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.763 0.237 0.000
R52 Pain, not elsewhere classified
0.762 0.238 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.762 0.238 0.000
E83.5 Disorders of calcium metabolism
0.761 0.239 0.000
G93 Other disorders of brain
0.761 0.239 0.000
N10-N16 Renal tubulo-interstitial diseases
0.761 0.239 0.000
O80-O84 Delivery
0.760 0.240 0.000
Z01.6 Radiological examination, not elsewhere classified
0.759 0.241 0.000
O61 Failed induction of labour
0.759 0.241 0.000
D64.9 Anaemia, unspecified
0.759 0.241 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.758 0.242 0.000
O73 Retained placenta and membranes, without haemorrhage
0.758 0.242 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.756 0.244 0.000
S10-S19 Injuries to the neck
0.755 0.245 0.000
R54 Senility
0.755 0.245 0.000
E27 Other disorders of adrenal gland
0.754 0.246 0.000
C50.2 Upper-inner quadrant of breast
0.754 0.246 0.000
G47.0 Disorders of initiating and maintaining sleep [insomnias]
0.754 0.246 0.000
H30-H36 Disorders of choroid and retina
0.752 0.248 0.000
W00-W19 Falls
0.752 0.248 0.000
Y43.3 Other antineoplastic drugs
0.751 0.249 0.000
C79.2 Secondary malignant neoplasm of skin
0.750 0.250 0.000
C78.7 Secondary malignant neoplasm of liver
0.749 0.251 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.749 0.251 0.000
R00.1 Bradycardia, unspecified
0.749 0.251 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.748 0.252 0.000
N00-N08 Glomerular diseases
0.748 0.252 0.000
D62 Acute posthaemorrhagic anaemia
0.748 0.252 0.000
I22 Subsequent myocardial infarction
0.748 0.252 0.000
I12.0 Hypertensive renal disease with renal failure
0.748 0.252 0.000
I21 Acute myocardial infarction
0.745 0.255 0.000
C77.4 Inguinal and lower limb lymph nodes
0.744 0.256 0.000
O69.1 Labour and delivery complicated by cord around neck, with compression
0.744 0.256 0.000
D61 Other aplastic anaemias
0.743 0.257 0.000
X60-X84 Intentional self-harm
0.743 0.257 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.743 0.257 0.000
Z13 Special screening examination for other diseases and disorders
0.741 0.259 0.000
D75 Other diseases of blood and blood-forming organs
0.741 0.259 0.000
Chapter X Diseases of the respiratory system
0.740 0.260 0.000
N61 Inflammatory disorders of breast
0.738 0.262 0.000
M13 Other arthritis
0.736 0.264 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.735 0.265 0.000
T79-T79 Certain early complications of trauma
0.735 0.265 0.000
Chapter V Mental and behavioural disorders
0.735 0.265 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.735 0.265 0.000
Y40 Systemic antibiotics
0.734 0.266 0.000
R60.0 Localised oedema
0.734 0.266 0.000
O40 Polyhydramnios
0.733 0.267 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.733 0.267 0.000
D52.9 Folate deficiency anaemia, unspecified
0.732 0.268 0.000
I24.8 Other forms of acute ischaemic heart disease
0.732 0.268 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.732 0.268 0.000
G40 Epilepsy
0.730 0.270 0.000
S82.1 Fracture of upper end of tibia
0.729 0.271 0.000
O75.7 Vaginal delivery following previous Caesarean section
0.728 0.272 0.000
Chapter XXII Codes for special purposes
0.728 0.272 0.000
O00-O08 Pregnancy with abortive outcome
0.728 0.272 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.727 0.273 0.000
Chapter VIII Diseases of the ear and mastoid process
0.727 0.273 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.726 0.274 0.000
R82 Other abnormal findings in urine
0.726 0.274 0.000
D63.0 Anaemia in neoplastic disease
0.726 0.274 0.000
G44 Other headache syndromes
0.724 0.276 0.000
O66 Other obstructed labour
0.723 0.277 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.723 0.277 0.000
G20-G26 Extrapyramidal and movement disorders
0.722 0.278 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.722 0.278 0.000
D73 Diseases of spleen
0.722 0.278 0.000
O75.2 Pyrexia during labour, not elsewhere classified
0.721 0.279 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.721 0.279 0.000
T66-T78 Other and unspecified effects of external causes
0.720 0.280 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.717 0.283 0.000
D55-D59 Haemolytic anaemias
0.717 0.283 0.000
O85-O92 Complications predominantly related to the puerperium
0.717 0.283 0.000
O62 Abnormalities of forces of labour
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.716 0.284 0.000
Z04 Examination and observation for other reasons
0.716 0.284 0.000
R68 Other general symptoms and signs
0.716 0.284 0.000
O74 Complications of anaesthesia during labour and delivery
0.716 0.284 0.000
O71 Other obstetric trauma
0.716 0.284 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.716 0.284 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.716 0.284 0.000
O60 Preterm delivery
0.716 0.284 0.000
Q60-Q64 Congenital malformations of the urinary system
0.716 0.284 0.000
G70-G73 Diseases of myoneural junction and muscle
0.715 0.285 0.000
Y44 Agents primarily affecting blood constituents
0.715 0.285 0.000
E10.3 With ophthalmic complications
0.715 0.285 0.000
S82.3 Fracture of lower end of tibia
0.715 0.285 0.000
G47.9 Sleep disorder, unspecified
0.714 0.286 0.000
G91 Hydrocephalus
0.714 0.286 0.000
N17-N19 Renal failure
0.714 0.286 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.714 0.286 0.000
N13 Obstructive and reflux uropathy
0.714 0.286 0.000
Z00 General examination and investigation of persons without complaint or reported diagnosis
0.714 0.286 0.000
T39.0 Salicylates
0.714 0.286 0.000
I23 Certain current complications following acute myocardial infarction
0.713 0.287 0.000
T33-T35 Frostbite
0.713 0.287 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.713 0.287 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.713 0.287 0.000
T00-T07 Injuries involving multiple body regions
0.713 0.287 0.000
J30-J39 Other diseases of upper respiratory tract
0.713 0.287 0.000
D69 Purpura and other haemorrhagic conditions
0.713 0.287 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.712 0.288 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.712 0.288 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.712 0.288 0.000
O48 Prolonged pregnancy
0.712 0.288 0.000
S82.8 Fractures of other parts of lower leg
0.712 0.288 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.712 0.288 0.000
C78.0 Secondary malignant neoplasm of lung
0.712 0.288 0.000
C79.6 Secondary malignant neoplasm of ovary
0.711 0.288 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.711 0.288 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.711 0.288 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.711 0.288 0.000
G96 Other disorders of central nervous system
0.711 0.289 0.000
I15 Secondary hypertension
0.710 0.290 0.000
I13 Hypertensive heart and renal disease
0.710 0.290 0.000
I11 Hypertensive heart disease
0.710 0.290 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.710 0.290 0.000
O42.9 Premature rupture of membranes, unspecified
0.709 0.291 0.000
M80-M85 Disorders of bone density and structure
0.708 0.291 0.000
C56 Malignant neoplasm of ovary
0.708 0.292 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.708 0.292 0.000
D74 Methaemoglobinaemia
0.708 0.292 0.000
D72 Other disorders of white blood cells
0.708 0.292 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.708 0.292 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.708 0.292 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.708 0.292 0.000
Z08 Follow-up examination after treatment for malignant neoplasm
0.708 0.292 0.000
C50.4 Upper-outer quadrant of breast
0.707 0.293 0.000
T93.2 Sequelae of other fractures of lower limb
0.707 0.293 0.000
W20-W49 Exposure to inanimate mechanical forces
0.707 0.293 0.000
D53 Other nutritional anaemias
0.706 0.294 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.706 0.294 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.705 0.294 0.000
G41 Status epilepticus
0.705 0.294 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.705 0.295 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.705 0.295 0.000
V20-V29 Motorcycle rider injured in transport accident
0.704 0.296 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.703 0.296 0.000
R62 Lack of expected normal physiological development
0.703 0.296 0.000
R57 Shock, not elsewhere classified
0.703 0.296 0.000
R64 Cachexia
0.703 0.296 0.000
R58 Haemorrhage, not elsewhere classified
0.703 0.296 0.000
M65-M68 Disorders of synovium and tendon
0.703 0.297 0.000
I20.8 Other forms of angina pectoris
0.703 0.297 0.000
E11.2 With renal complications
0.702 0.298 0.000
I25.6 Silent myocardial ischaemia
0.702 0.298 0.000
I25.4 Coronary artery aneurysm
0.702 0.298 0.000
I25.3 Aneurysm of heart
0.702 0.298 0.000
R56 Convulsions, not elsewhere classified
0.702 0.298 0.000
R49 Voice disturbances
0.701 0.299 0.000
G95 Other diseases of spinal cord
0.701 0.299 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.701 0.299 0.000
O72.2 Delayed and secondary postpartum haemorrhage
0.701 0.299 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.699 0.301 0.000
Y35-Y36 Legal intervention and operations of war
0.699 0.301 0.000
Y10-Y34 Event of undetermined intent
0.699 0.301 0.000
Y00-Y09 Assault
0.699 0.301 0.000
X85-X99 Assault
0.699 0.301 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.699 0.301 0.000
X50-X57 Overexertion, travel and privation
0.699 0.301 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.699 0.301 0.000
X30-X39 Exposure to forces of nature
0.699 0.301 0.000
X20-X29 Contact with venomous animals and plants
0.699 0.301 0.000
X10-X19 Contact with heat and hot substances
0.699 0.301 0.000
X00-X09 Exposure to smoke, fire and flames
0.699 0.301 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.699 0.301 0.000
W75-W84 Other accidental threats to breathing
0.699 0.301 0.000
W65-W74 Accidental drowning and submersion
0.699 0.301 0.000
W50-W64 Exposure to animate mechanical forces
0.699 0.301 0.000
V98-V99 Other and unspecified transport accidents
0.699 0.301 0.000
V95-V97 Air and space transport accidents
0.699 0.301 0.000
V90-V94 Water transport accidents
0.699 0.301 0.000
V80-V89 Other land transport accidents
0.699 0.301 0.000
V70-V79 Bus occupant injured in transport accident
0.699 0.301 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.699 0.301 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.699 0.301 0.000
V40-V49 Car occupant injured in transport accident
0.699 0.301 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.699 0.301 0.000
V01-V09 Pedestrian injured in transport accident
0.699 0.301 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.698 0.302 0.000
H36 Retinal disorders in diseases classified elsewhere
0.698 0.302 0.000
E40-E46 Malnutrition
0.698 0.302 0.000
C77.0 Lymph nodes of head, face and neck
0.698 0.302 0.000
G47.8 Other sleep disorders
0.697 0.302 0.000
G47.4 Narcolepsy and cataplexy
0.697 0.302 0.000
G47.2 Disorders of the sleep-wake schedule
0.697 0.302 0.000
G47.1 Disorders of excessive somnolence [hypersomnias]
0.697 0.302 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.695 0.305 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.694 0.306 0.000
O69.8 Labour and delivery complicated by other cord complications
0.694 0.306 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.694 0.306 0.000
E14 Unspecified diabetes mellitus
0.693 0.307 0.000
D06 Carcinoma in situ of cervix uteri
0.692 0.308 0.000
M10 Gout
0.692 0.308 0.000
E11.5 With peripheral circulatory complications
0.692 0.308 0.000
G30-G32 Other degenerative diseases of the nervous system
0.691 0.309 0.000
R61 Hyperhidrosis
0.690 0.310 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.689 0.310 0.000
I84 Haemorrhoids
0.690 0.310 0.000
Y52 Agents primarily affecting the cardiovascular system
0.689 0.311 0.000
R50 Fever of unknown origin
0.689 0.311 0.000
E10.9 Without complications
0.689 0.311 0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress
0.688 0.312 0.000
O64.0 Obstructed labour due to incomplete rotation of foetal head
0.686 0.314 0.000
G43.9 Migraine, unspecified
0.686 0.314 0.000
E10.4 With neurological complications
0.684 0.316 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.684 0.316 0.000
G80 Infantile cerebral palsy
0.683 0.317 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.683 0.317 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.683 0.317 0.000
S92 Fracture of foot, except ankle
0.683 0.317 0.000
T39.1 4-Aminophenol derivatives
0.682 0.318 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.682 0.318 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.682 0.318 0.000
N99-N99 Other disorders of the genitourinary system
0.680 0.320 0.000
E11.6 With other specified complications
0.679 0.320 0.000
Y43.1 Antineoplastic antimetabolites
0.679 0.321 0.000
G62.9 Polyneuropathy, unspecified
0.679 0.321 0.000
C53 Malignant neoplasm of cervix uteri
0.678 0.322 0.000
O45 Premature separation of placenta [abruptio placentae]
0.676 0.324 0.000
O44 Placenta praevia
0.676 0.324 0.000
O43 Placental disorders
0.676 0.324 0.000
O41 Other disorders of amniotic fluid and membranes
0.676 0.324 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.676 0.324 0.000
O33 Maternal care for known or suspected disproportion
0.676 0.324 0.000
O31 Complications specific to multiple gestation
0.676 0.324 0.000
O30 Multiple gestation
0.676 0.324 0.000
I60-I69 Cerebrovascular diseases
0.676 0.324 0.000
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension
0.676 0.324 0.000
S89 Other and unspecified injuries of lower leg
0.675 0.325 0.000
M13.9 Arthritis, unspecified
0.675 0.325 0.000
R02 Gangrene, not elsewhere classified
0.675 0.325 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.675 0.325 0.000
N02 Recurrent and persistent haematuria
0.674 0.326 0.000
M86-M90 Other osteopathies
0.674 0.326 0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes
0.673 0.327 0.000
E13 Other specified diabetes mellitus
0.673 0.327 0.000
E12 Malnutrition-related diabetes mellitus
0.673 0.327 0.000
C78.2 Secondary malignant neoplasm of pleura
0.672 0.328 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.672 0.328 0.000
C54 Malignant neoplasm of corpus uteri
0.671 0.329 0.000
G82 Paraplegia and tetraplegia
0.671 0.329 0.000
R15 Faecal incontinence
0.670 0.330 0.000
S40-S49 Injuries to the shoulder and upper arm
0.670 0.330 0.000
E88 Other metabolic disorders
0.670 0.330 0.000
O36 Maternal care for other known or suspected foetal problems
0.669 0.331 0.000
Y59 Other and unspecified vaccines and biological substances
0.668 0.332 0.000
Y58 Bacterial vaccines
0.668 0.332 0.000
Y57 Other and unspecified drugs and medicaments
0.668 0.332 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.668 0.332 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.668 0.332 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.668 0.332 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.668 0.332 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.668 0.332 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.668 0.332 0.000
Y48 Anaesthetics and therapeutic gases
0.668 0.332 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.668 0.332 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.668 0.332 0.000
O70.2 Third degree perineal laceration during delivery
0.668 0.332 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.667 0.332 0.000
S88 Traumatic amputation of lower leg
0.667 0.333 0.000
S87 Crushing injury of lower leg
0.667 0.333 0.000
S86 Injury of muscle and tendon at lower leg level
0.667 0.333 0.000
S85 Injury of blood vessels at lower leg level
0.667 0.333 0.000
S84 Injury of nerves at lower leg level
0.667 0.333 0.000
Q00-Q07 Congenital malformations of the nervous system
0.667 0.333 0.000
D80-D89 Certain disorders involving the immune mechanism
0.665 0.335 0.000
S20 Superficial injury of thorax
0.665 0.335 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.664 0.336 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.664 0.336 0.000
M79.6 Pain in limb
0.664 0.336 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.664 0.336 0.000
C50.9 Breast, unspecified
0.664 0.336 0.000
N18 Chronic renal failure
0.664 0.336 0.000
T31 Burns classified according to extent of body surface involved
0.663 0.336 0.000
S80 Superficial injury of lower leg
0.662 0.338 0.000
I25.5 Ischaemic cardiomyopathy
0.662 0.338 0.000
R00.0 Tachycardia, unspecified
0.661 0.339 0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress
0.661 0.339 0.000
T93.8 Sequelae of other specified injuries of lower limb
0.661 0.339 0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
0.661 0.339 0.000
D45 Polycythaemia vera
0.660 0.340 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.660 0.340 0.000
O32.8 Maternal care for other malpresentation of foetus
0.660 0.340 0.000
H36.0 Diabetic retinopathy
0.660 0.340 0.000
C80.9 Malignant neoplasm, unspecified
0.659 0.341 0.000
H10-H13 Disorders of conjunctiva
0.659 0.341 0.000
C50.0 Nipple and areola
0.659 0.341 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.659 0.341 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.658 0.342 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.658 0.342 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.658 0.342 0.000
R17 Unspecified jaundice
0.658 0.342 0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid
0.658 0.342 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.657 0.343 0.000
R60.9 Oedema, unspecified
0.657 0.343 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.655 0.344 0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level
0.655 0.344 0.000
Y98 Lifestyle-related condition
0.655 0.344 0.000
Y97 Environmental-pollution-related condition
0.655 0.344 0.000
Y96 Work-related condition
0.655 0.344 0.000
S81.8 Open wound of other parts of lower leg
0.655 0.345 0.000
E55 Vitamin D deficiency
0.655 0.345 0.000
Q50-Q56 Congenital malformations of genital organs
0.655 0.345 0.000
D46 Myelodysplastic syndromes
0.654 0.345 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.654 0.345 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.654 0.345 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.654 0.345 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.654 0.345 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.654 0.345 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.654 0.345 0.000
Z10 Routine general health check-up of defined subpopulation
0.654 0.345 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.654 0.346 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.654 0.346 0.000
D51.2 Transcobalamin II deficiency
0.654 0.346 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.654 0.346 0.000
I24.1 Dressler's syndrome
0.654 0.346 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.654 0.346 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.654 0.346 0.000
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms
0.654 0.346 0.000
D05 Carcinoma in situ of breast
0.652 0.348 0.000
M72 Fibroblastic disorders
0.652 0.348 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.652 0.348 0.000
O72.3 Postpartum coagulation defects
0.651 0.349 0.000
S82.5 Fracture of medial malleolus
0.651 0.349 0.000
C15-C26 Malignant neoplasms of digestive organs
0.651 0.349 0.000
S82.2 Fracture of shaft of tibia
0.650 0.350 0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium
0.650 0.350 0.000
N60 Benign mammary dysplasia
0.650 0.350 0.000
E83.4 Disorders of magnesium metabolism
0.650 0.350 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.650 0.350 0.000
D50.1 Sideropenic dysphagia
0.650 0.350 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.649 0.351 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.649 0.351 0.000
G90 Disorders of autonomic nervous system
0.649 0.351 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.649 0.351 0.000
G92 Toxic encephalopathy
0.649 0.351 0.000
D37.5 Rectum
0.649 0.351 0.000
S82.4 Fracture of fibula alone
0.648 0.352 0.000
G83 Other paralytic syndromes
0.647 0.352 0.000
O42.0 Premature rupture of membranes, onset of labour within 24 hours
0.647 0.353 0.000
D50.9 Iron deficiency anaemia, unspecified
0.647 0.353 0.000
C73 Malignant neoplasm of thyroid gland
0.646 0.354 0.000
O42.1 Premature rupture of membranes, onset of labour after 24 hours
0.645 0.354 0.000
C77.9 Lymph node, unspecified
0.645 0.355 0.000
D37.7 Other digestive organs
0.645 0.355 0.000
R47 Speech disturbances, not elsewhere classified
0.644 0.355 0.000
Z37 Outcome of delivery
0.643 0.357 0.000
O70.1 Second degree perineal laceration during delivery
0.643 0.357 0.000
O47 False labour
0.643 0.357 0.000
N13.3 Other and unspecified hydronephrosis
0.643 0.357 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.642 0.358 0.000
M13.99 Arthritis, unspecified (Site unspecified)
0.642 0.358 0.000
H53-H54 Visual disturbances and blindness
0.642 0.358 0.000
R80 Isolated proteinuria
0.641 0.359 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.641 0.359 0.000
V10-V19 Pedal cyclist injured in transport accident
0.639 0.360 0.000
T59 Toxic effect of other gases, fumes and vapours
0.638 0.362 0.000
D04 Carcinoma in situ of skin
0.637 0.363 0.000
G93.4 Encephalopathy, unspecified
0.637 0.363 0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified
0.636 0.364 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.636 0.364 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.636 0.364 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.635 0.365 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.635 0.365 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.635 0.365 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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