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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12994538
log Bayes Factor = 8.90381
Chromosome 2   position 151,754,956  (GRCh37) Explore rs12994538 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XXI Factors influencing health status and contact with health services
0.999 0.001 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.998 0.002 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.996 0.004 0.000
Chapter X Diseases of the respiratory system
0.989 0.011 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.985 0.015 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.977 0.023 0.000
Z92 Personal history of medical treatment
0.977 0.023 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.974 0.026 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.970 0.030 0.000
H53-H54 Visual disturbances and blindness
0.969 0.031 0.000
Chapter VI Diseases of the nervous system
0.963 0.037 0.000
Z50 Care involving use of rehabilitation procedures
0.958 0.042 0.000
Z83 Family history of other specific disorders
0.958 0.042 0.000
R00 Abnormalities of heart beat
0.957 0.043 0.000
Z92.3 Personal history of irradiation
0.954 0.046 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.953 0.047 0.000
H00 Hordeolum and chalazion
0.952 0.048 0.000
Chapter XX External causes of morbidity and mortality
0.947 0.053 0.000
H01 Other inflammation of eyelid
0.947 0.053 0.000
R50-R69 General symptoms and signs
0.941 0.059 0.000
R00.0 Tachycardia, unspecified
0.941 0.059 0.000
Z92.1 Personal history of long-term (current) use of anticoagulants
0.939 0.061 0.000
Z43 Attention to artificial openings
0.938 0.062 0.000
H30-H36 Disorders of choroid and retina
0.938 0.062 0.000
R50 Fever of unknown origin
0.936 0.064 0.000
J95-J99 Other diseases of the respiratory system
0.935 0.065 0.000
S70-S79 Injuries to the hip and thigh
0.934 0.066 0.000
R50.9 Fever, unspecified
0.931 0.069 0.000
R53 Malaise and fatigue
0.929 0.071 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.927 0.073 0.000
S80-S89 Injuries to the knee and lower leg
0.927 0.073 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.924 0.076 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.922 0.078 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.920 0.080 0.000
J40-J47 Chronic lower respiratory diseases
0.918 0.082 0.000
Z88.1 Personal history of allergy to other antibiotic agents
0.916 0.084 0.000
Z43.2 Attention to ileostomy
0.915 0.085 0.000
Z50.7 Occupational therapy and vocational rehabilitation, not elsewhere classified
0.910 0.090 0.000
H04 Disorders of lachrymal system
0.908 0.092 0.000
H00.1 Chalazion
0.903 0.097 0.000
H54 Blindness and low vision
0.902 0.098 0.000
Chapter I Certain infectious and parasitic diseases
0.902 0.098 0.000
Z83.5 Family history of eye and ear disorders
0.900 0.100 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.898 0.102 0.000
Z46 Fitting and adjustment of other devices
0.897 0.103 0.000
R05 Cough
0.894 0.106 0.000
W20-W49 Exposure to inanimate mechanical forces
0.891 0.109 0.000
S40-S49 Injuries to the shoulder and upper arm
0.891 0.109 0.000
T66-T78 Other and unspecified effects of external causes
0.889 0.111 0.000
H01.0 Blepharitis
0.886 0.114 0.000
S72 Fracture of femur
0.886 0.114 0.000
S20-S29 Injuries to the thorax
0.885 0.114 0.000
R04 Haemorrhage from respiratory passages
0.883 0.117 0.000
G40-G47 Episodic and paroxysmal disorders
0.880 0.120 0.000
H53 Visual disturbances
0.876 0.124 0.000
R47-R49 Symptoms and signs involving speech and voice
0.876 0.124 0.000
S82 Fracture of lower leg, including ankle
0.875 0.125 0.000
S90-S99 Injuries to the ankle and foot
0.874 0.126 0.000
Z94 Transplanted organ and tissue status
0.871 0.129 0.000
Z60 Problems related to social environment
0.869 0.131 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.862 0.138 0.000
H54.4 Blindness, one eye
0.862 0.138 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.860 0.140 0.000
Z50.5 Speech therapy
0.860 0.140 0.000
J98 Other respiratory disorders
0.859 0.141 0.000
Z50.1 Other physical therapy
0.859 0.141 0.000
J40 Bronchitis, not specified as acute or chronic
0.858 0.142 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.857 0.143 0.000
S72.0 Fracture of neck of femur
0.856 0.144 0.000
H35 Other retinal disorders
0.855 0.145 0.000
M05-M14 Inflammatory polyarthropathies
0.855 0.145 0.000
E10-E14 Diabetes mellitus
0.854 0.146 0.000
Z83.3 Family history of diabetes mellitus
0.851 0.149 0.000
Z88.5 Personal history of allergy to narcotic agent
0.851 0.149 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.849 0.151 0.000
H05 Disorders of orbit
0.849 0.151 0.000
Z87 Personal history of other diseases and conditions
0.846 0.154 0.000
Z49 Care involving dialysis
0.846 0.154 0.000
J98.1 Pulmonary collapse
0.845 0.155 0.000
Z52 Donors of organs and tissues
0.840 0.160 0.000
E11 Non-insulin-dependent diabetes mellitus
0.835 0.165 0.000
S72.00 Fracture of neck of femur (closed)
0.834 0.166 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.833 0.167 0.000
T79-T79 Certain early complications of trauma
0.832 0.168 0.000
Z89 Acquired absence of limb
0.832 0.168 0.000
Z87.1 Personal history of diseases of the digestive system
0.831 0.169 0.000
H55-H59 Other disorders of eye and adnexa
0.831 0.169 0.000
J20-J22 Other acute lower respiratory infections
0.830 0.170 0.000
T86 Failure and rejection of transplanted organs and tissues
0.828 0.172 0.000
M65-M68 Disorders of synovium and tendon
0.827 0.173 0.000
Z92.8 Personal history of other medical treatment
0.827 0.173 0.000
E20-E35 Disorders of other endocrine glands
0.826 0.174 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.822 0.178 0.000
J43 Emphysema
0.821 0.179 0.000
W25 Contact with sharp glass
0.820 0.180 0.000
R47 Speech disturbances, not elsewhere classified
0.817 0.183 0.000
A00-A09 Intestinal infectious diseases
0.815 0.185 0.000
G47 Sleep disorders
0.813 0.187 0.000
G30-G32 Other degenerative diseases of the nervous system
0.812 0.188 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.812 0.188 0.000
R09.1 Pleurisy
0.812 0.188 0.000
Z96 Presence of other functional implants
0.811 0.189 0.000
J09-J18 Influenza and pneumonia
0.811 0.189 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.811 0.189 0.000
E11.3 With ophthalmic complications
0.809 0.191 0.000
Z60.2 Living alone
0.809 0.191 0.000
M40-M43 Deforming dorsopathies
0.808 0.192 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.806 0.194 0.000
H10-H13 Disorders of conjunctiva
0.805 0.195 0.000
M06 Other rheumatoid arthritis
0.800 0.200 0.000
J60-J70 Lung diseases due to external agents
0.797 0.203 0.000
Z57 Occupational exposure to risk-factors
0.795 0.205 0.000
H53.0 Amblyopia ex anopsia
0.793 0.207 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.791 0.209 0.000
R54 Senility
0.789 0.211 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.788 0.211 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.787 0.213 0.000
A80-A89 Viral infections of the central nervous system
0.787 0.213 0.000
H01.8 Other specified inflammation of eyelid
0.786 0.214 0.000
Z82.3 Family history of stroke
0.786 0.214 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.785 0.215 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.783 0.217 0.000
R00.1 Bradycardia, unspecified
0.780 0.220 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.779 0.221 0.000
S82.4 Fracture of fibula alone
0.776 0.224 0.000
Z83.1 Family history of other infectious and parasitic diseases
0.775 0.225 0.000
R01 Cardiac murmurs and other cardiac sounds
0.775 0.225 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.774 0.226 0.000
R04.0 Epistaxis
0.773 0.227 0.000
H00.0 Hordeolum and other deep inflammation of eyelid
0.773 0.227 0.000
H36 Retinal disorders in diseases classified elsewhere
0.772 0.228 0.000
Z94.8 Other transplanted organ and tissue status
0.771 0.229 0.000
Z54 Convalescence
0.770 0.230 0.000
W25.9 Unspecified place
0.769 0.231 0.000
H04.1 Other disorders of lachrymal gland
0.769 0.231 0.000
W50-W64 Exposure to animate mechanical forces
0.768 0.232 0.000
Z93 Artificial opening status
0.768 0.232 0.000
Z46.6 Fitting and adjustment of urinary device
0.766 0.234 0.000
R47.8 Other and unspecified speech disturbances
0.762 0.238 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.760 0.240 0.000
S81 Open wound of lower leg
0.759 0.241 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.758 0.242 0.000
M86-M90 Other osteopathies
0.756 0.243 0.000
J00-J06 Acute upper respiratory infections
0.755 0.245 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.755 0.245 0.000
H35.8 Other specified retinal disorders
0.754 0.246 0.000
J43.9 Emphysema, unspecified
0.752 0.248 0.000
Z46.8 Fitting and adjustment of other specified devices
0.752 0.248 0.000
S27 Injury of other and unspecified intrathoracic organs
0.752 0.248 0.000
E11.1 With ketoacidosis
0.752 0.248 0.000
G47.3 Sleep apnoea
0.752 0.248 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.751 0.249 0.000
Z50.4 Psychotherapy, not elsewhere classified
0.749 0.251 0.000
T68 Hypothermia
0.749 0.251 0.000
V10-V19 Pedal cyclist injured in transport accident
0.749 0.251 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.748 0.252 0.000
R50.0 Fever with chills
0.748 0.252 0.000
T78 Adverse effects, not elsewhere classified
0.746 0.254 0.000
Z88.4 Personal history of allergy to anaesthetic agent
0.746 0.254 0.000
M07 Psoriatic and enteropathic arthropathies
0.745 0.255 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.745 0.255 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.743 0.257 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.743 0.257 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.743 0.257 0.000
R00.8 Other and unspecified abnormalities of heart beat
0.743 0.257 0.000
R04.2 Haemoptysis
0.742 0.258 0.000
S82.2 Fracture of shaft of tibia
0.740 0.260 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.739 0.261 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.739 0.261 0.000
Z63 Other problems related to primary support group, including family circumstances
0.739 0.261 0.000
Chapter II Neoplasms
0.738 0.262 0.000
H53.4 Visual field defects
0.738 0.262 0.000
M67 Other disorders of synovium and tendon
0.737 0.263 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.736 0.263 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.732 0.268 0.000
S92 Fracture of foot, except ankle
0.732 0.268 0.000
Z96.4 Presence of endocrine implants
0.730 0.269 0.000
R68 Other general symptoms and signs
0.730 0.269 0.000
Z96.7 Presence of other bone and tendon implants
0.730 0.270 0.000
G82 Paraplegia and tetraplegia
0.730 0.270 0.000
Z83.4 Family history of other endocrine, nutritional and metabolic diseases
0.730 0.270 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.729 0.271 0.000
Z53 Persons encountering health services for specifie procedures, not carried out
0.729 0.271 0.000
Z56 Problems related to employment and unemployment
0.727 0.273 0.000
Z84 Family history of other conditions
0.727 0.273 0.000
H35.4 Peripheral retinal degeneration
0.727 0.273 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.726 0.274 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.724 0.276 0.000
Z49.2 Other dialysis
0.723 0.277 0.000
Z52.4 Kidney donor
0.722 0.278 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.722 0.278 0.000
H04.3 Acute and unspecified inflammation of lachrymal passages
0.721 0.279 0.000
Z82.0 Family history of epilepsy and other diseases of the nervous system
0.720 0.279 0.000
H34 Retinal vascular occlusions
0.720 0.280 0.000
H05.2 Exophthalmic conditions
0.719 0.281 0.000
S32 Fracture of lumbar spine and pelvis
0.718 0.282 0.000
A30-A49 Other bacterial diseases
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.716 0.284 0.000
M60-M63 Disorders of muscles
0.716 0.284 0.000
H40-H42 Glaucoma
0.716 0.284 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.715 0.285 0.000
G20-G26 Extrapyramidal and movement disorders
0.714 0.286 0.000
B15-B19 Viral hepatitis
0.714 0.286 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.713 0.287 0.000
S82.0 Fracture of patella
0.713 0.287 0.000
S43.0 Dislocation of shoulder joint
0.713 0.287 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.713 0.287 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.713 0.287 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.712 0.288 0.000
G81 Hemiplegia
0.711 0.289 0.000
Z89.6 Acquired absence of leg above knee
0.710 0.289 0.000
V40-V49 Car occupant injured in transport accident
0.709 0.291 0.000
W21 Striking against or struck by sports equipment
0.708 0.292 0.000
H02 Other disorders of eyelid
0.707 0.293 0.000
Z43.1 Attention to gastrostomy
0.706 0.294 0.000
Z44 Fitting and adjustment of external prosthetic device
0.706 0.294 0.000
W49 Exposure to other and unspecified inanimate mechanical forces
0.705 0.295 0.000
S82.40 Fracture of fibula alone (closed)
0.704 0.296 0.000
H04.4 Chronic inflammation of lachrymal passages
0.704 0.296 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.704 0.296 0.000
Z50.2 Alcohol rehabilitation
0.703 0.296 0.000
Y00-Y09 Assault
0.703 0.296 0.000
A08 Viral and other specified intestinal infections
0.701 0.299 0.000
M06.9 Rheumatoid arthritis, unspecified
0.701 0.299 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.700 0.300 0.000
Z92.9 Personal history of medical treatment, unspecified
0.700 0.300 0.000
Z92.5 Personal history of rehabilitation measures
0.700 0.300 0.000
W29 Contact with other powered hand tools and household machinery
0.698 0.302 0.000
Z57.2 Occupational exposure to dust
0.698 0.302 0.000
X20-X29 Contact with venomous animals and plants
0.697 0.303 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.697 0.303 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.695 0.305 0.000
M06.0 Seronegative rheumatoid arthritis
0.695 0.305 0.000
Z81 Family history of mental and behavioural disorders
0.693 0.307 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.692 0.308 0.000
Y95 Nosocomial condition
0.692 0.308 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.692 0.308 0.000
T80.2 Infections following infusion, transfusion and therapeutic injection
0.691 0.309 0.000
S40 Superficial injury of shoulder and upper arm
0.691 0.309 0.000
S10-S19 Injuries to the neck
0.691 0.309 0.000
R47.0 Dysphasia and aphasia
0.691 0.309 0.000
T86.8 Failure and rejection of other transplanted organs and tissues
0.691 0.309 0.000
S20 Superficial injury of thorax
0.690 0.310 0.000
S60-S69 Injuries to the wrist and hand
0.690 0.310 0.000
J42 Unspecified chronic bronchitis
0.689 0.311 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.689 0.311 0.000
H35.6 Retinal haemorrhage
0.689 0.311 0.000
Z53.0 Procedure not carried out because of contraindication
0.688 0.312 0.000
Z50.6 Orthoptic training
0.687 0.313 0.000
Z50.3 Drug rehabilitation
0.687 0.313 0.000
Z83.6 Family history of diseases of the respiratory system
0.687 0.313 0.000
Z83.2 Family history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.687 0.313 0.000
Z83.0 Family history of human immunodeficiency virus [HIV]
0.687 0.313 0.000
J06 Acute upper respiratory infections of multiple and unspecified sites
0.687 0.313 0.000
V80-V89 Other land transport accidents
0.686 0.314 0.000
C64-C68 Malignant neoplasms of urinary tract
0.685 0.315 0.000
J20 Acute bronchitis
0.685 0.315 0.000
R57 Shock, not elsewhere classified
0.685 0.315 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.685 0.315 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.685 0.315 0.000
Z46.2 Fitting and adjustment of other devices related to nervous system and special senses
0.684 0.316 0.000
T87 Complications peculiar to reattachment and amputation
0.684 0.316 0.000
Z65 Problems related to other psychosocial circumstances
0.683 0.316 0.000
Z64 Problems related to certain psychosocial circumstances
0.683 0.316 0.000
Z62 Other problems related to upbringing
0.683 0.316 0.000
Z61 Problems related to negative life events in childhood
0.683 0.316 0.000
Z59 Problems related to housing and economic circumstances
0.683 0.316 0.000
Z58 Problems related to physical environment
0.683 0.316 0.000
Z55 Problems related to education and literacy
0.683 0.316 0.000
S80 Superficial injury of lower leg
0.683 0.317 0.000
R26 Abnormalities of gait and mobility
0.682 0.318 0.000
Z88.3 Personal history of allergy to other anti-infective agents
0.682 0.318 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.681 0.319 0.000
D00-D09 In situ neoplasms
0.680 0.320 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.680 0.320 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.680 0.320 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.679 0.321 0.000
Y35-Y36 Legal intervention and operations of war
0.679 0.321 0.000
Y10-Y34 Event of undetermined intent
0.679 0.321 0.000
X85-X99 Assault
0.679 0.321 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.679 0.321 0.000
X50-X57 Overexertion, travel and privation
0.679 0.321 0.000
X30-X39 Exposure to forces of nature
0.679 0.321 0.000
X10-X19 Contact with heat and hot substances
0.679 0.321 0.000
X00-X09 Exposure to smoke, fire and flames
0.679 0.321 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.679 0.321 0.000
W75-W84 Other accidental threats to breathing
0.679 0.321 0.000
W65-W74 Accidental drowning and submersion
0.679 0.321 0.000
V98-V99 Other and unspecified transport accidents
0.679 0.321 0.000
V95-V97 Air and space transport accidents
0.679 0.321 0.000
V90-V94 Water transport accidents
0.679 0.321 0.000
V70-V79 Bus occupant injured in transport accident
0.679 0.321 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.679 0.321 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.679 0.321 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.679 0.321 0.000
V01-V09 Pedestrian injured in transport accident
0.679 0.321 0.000
H01.9 Inflammation of eyelid, unspecified
0.679 0.321 0.000
H01.1 Non-infectious dermatoses of eyelid
0.679 0.321 0.000
B65-B83 Helminthiases
0.679 0.321 0.000
E11.0 With coma
0.679 0.321 0.000
Z40 Prophylactic surgery
0.678 0.321 0.000
R58 Haemorrhage, not elsewhere classified
0.678 0.322 0.000
E29 Testicular dysfunction
0.678 0.322 0.000
H53.8 Other visual disturbances
0.676 0.324 0.000
E50-E64 Other nutritional deficiencies
0.675 0.325 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.675 0.325 0.000
R62 Lack of expected normal physiological development
0.675 0.325 0.000
R64 Cachexia
0.675 0.325 0.000
S82.3 Fracture of lower end of tibia
0.674 0.326 0.000
M67.8 Other specified disorders of synovium and tendon
0.673 0.327 0.000
E40-E46 Malnutrition
0.673 0.327 0.000
Z43.9 Attention to unspecified artificial opening
0.673 0.327 0.000
Z43.8 Attention to other artificial openings
0.673 0.327 0.000
Z43.7 Attention to artificial vagina
0.673 0.327 0.000
Z43.5 Attention to cyctostomy
0.673 0.327 0.000
Z43.4 Attention to other artificial openings of digestive tract
0.673 0.327 0.000
Z43.0 Attention to tracheostomy
0.673 0.327 0.000
G30 Alzheimer's disease
0.673 0.327 0.000
X60-X84 Intentional self-harm
0.672 0.327 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.672 0.328 0.000
H31 Other disorders of choroid
0.672 0.328 0.000
H30 Chorioretinal inflammation
0.672 0.328 0.000
G62 Other polyneuropathies
0.672 0.328 0.000
M50-M54 Other dorsopathies
0.672 0.328 0.000
R50.2 Drug-induced fever
0.671 0.329 0.000
R50.1 Persistent fever
0.671 0.329 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.671 0.329 0.000
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities
0.670 0.329 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.670 0.329 0.000
J96 Respiratory failure, not elsewhere classified
0.670 0.330 0.000
S79 Other and unspecified injuries of hip and thigh
0.670 0.330 0.000
S78 Traumatic amputation of hip and thigh
0.670 0.330 0.000
S77 Crushing injury of hip and thigh
0.670 0.330 0.000
S76 Injury of muscle and tendon at hip and thigh level
0.670 0.330 0.000
S75 Injury of blood vessels at hip and thigh level
0.670 0.330 0.000
S74 Injury of nerves at hip and thigh level
0.670 0.330 0.000
S71 Open wound of hip and thigh
0.670 0.330 0.000
Z97 Presence of other devices
0.668 0.331 0.000
Z87.2 Personal history of diseases of the skin and subcutaneous tissue
0.668 0.332 0.000
A04 Other bacterial intestinal infections
0.668 0.332 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.667 0.332 0.000
M07.3 Other psoriatic arthropathies
0.667 0.333 0.000
R09.2 Respiratory arrest
0.666 0.334 0.000
Z82.5 Family history of asthma and other chronic lower respiratory diseases
0.666 0.334 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.665 0.335 0.000
G80 Infantile cerebral palsy
0.665 0.335 0.000
S88 Traumatic amputation of lower leg
0.665 0.335 0.000
S87 Crushing injury of lower leg
0.665 0.335 0.000
S86 Injury of muscle and tendon at lower leg level
0.665 0.335 0.000
S85 Injury of blood vessels at lower leg level
0.665 0.335 0.000
S84 Injury of nerves at lower leg level
0.665 0.335 0.000
H54.0 Blindness, both eyes
0.664 0.336 0.000
H02.4 Ptosis of eyelid
0.664 0.336 0.000
Z43.6 Attention to other artificial openings of urinary tract
0.664 0.336 0.000
J90-J94 Other diseases of pleura
0.664 0.336 0.000
Z49.1 Extracorporeal dialysis
0.663 0.336 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.662 0.338 0.000
R50.8 Other specified fever
0.662 0.338 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.661 0.339 0.000
Z45 Adjustment and management of implanted device
0.660 0.340 0.000
M41 Scoliosis
0.659 0.341 0.000
J41 Simple and mucopurulent chronic bronchitis
0.658 0.342 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.658 0.342 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.658 0.342 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.657 0.343 0.000
H33 Retinal detachments and breaks
0.656 0.344 0.000
E22 Hyperfunction of pituitary gland
0.656 0.344 0.000
H35.9 Retinal disorder, unspecified
0.655 0.344 0.000
Z89.4 Acquired absence of foot and ankle
0.655 0.345 0.000
A87 Viral meningitis
0.655 0.345 0.000
H36.0 Diabetic retinopathy
0.653 0.347 0.000
H05.0 Acute inflammation of orbit
0.652 0.348 0.000
S72.3 Fracture of shaft of femur
0.652 0.348 0.000
M05 Seropositive rheumatoid arthritis
0.652 0.348 0.000
M66 Spontaneous rupture of synovium and tendon
0.651 0.348 0.000
H04.9 Disorder of lachrymal system, unspecified
0.651 0.349 0.000
H04.8 Other disorders of lachrymal system
0.651 0.349 0.000
H04.6 Other changes in lachrymal passages
0.651 0.349 0.000
H04.0 Dacryoadenitis
0.651 0.349 0.000
Z94.0 Kidney transplant status
0.650 0.350 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.650 0.350 0.000
S41 Open wound of shoulder and upper arm
0.649 0.351 0.000
E28 Ovarian dysfunction
0.649 0.351 0.000
Z96.6 Presence of orthopaedic joint implants
0.649 0.351 0.000
A41 Other septicaemia
0.649 0.351 0.000
J45 Asthma
0.648 0.352 0.000
A86 Unspecified viral encephalitis
0.648 0.352 0.000
S82.6 Fracture of lateral malleolus
0.647 0.353 0.000
H11 Other disorders of conjunctiva
0.647 0.353 0.000
J22 Unspecified acute lower respiratory infection
0.647 0.353 0.000
H54.6 Unqualified visual loss, one eye
0.647 0.353 0.000
H54.5 Low vision, one eye
0.647 0.353 0.000
H54.3 Unqualified visual loss, both eyes
0.647 0.353 0.000
H54.2 Low vision, both eyes
0.647 0.353 0.000
H54.1 Blindness, one eye, low vision, other eye
0.647 0.353 0.000
B99-B99 Other infectious diseases
0.647 0.353 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.647 0.353 0.000
B50-B64 Protozoal diseases
0.647 0.353 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.647 0.353 0.000
A75-A79 Rickettsioses
0.647 0.353 0.000
A70-A74 Other diseases caused by chlamydiae
0.647 0.353 0.000
A65-A69 Other spirochaetal diseases
0.647 0.353 0.000
A20-A28 Certain zoonotic bacterial diseases
0.647 0.353 0.000
A15-A19 Tuberculosis
0.647 0.353 0.000
M00-M03 Infectious arthropathies
0.646 0.353 0.000
H50 Other strabismus
0.646 0.354 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.646 0.354 0.000
M91-M94 Chondropathies
0.645 0.354 0.000
M40 Kyphosis and lordosis
0.645 0.355 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.645 0.355 0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft
0.644 0.356 0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract
0.644 0.356 0.000
T83.2 Mechanical complication of graft of urinary organ
0.644 0.356 0.000
H35.2 Other proliferative retinopathy
0.644 0.356 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.643 0.357 0.000
Z46.9 Fitting and adjustment of other unspecified device
0.643 0.357 0.000
Z46.7 Fitting and adjustment of orthopaedic device
0.643 0.357 0.000
Z46.5 Fitting and adjustment of ileostomy and other intestinal appliances
0.643 0.357 0.000
Z46.4 Fitting and adjustment of orthodontic device
0.643 0.357 0.000
Z46.3 Fitting and adjustment of dental prosthetic device
0.643 0.357 0.000
Z46.1 Fitting and adjustment of hearing aid
0.643 0.357 0.000
Z46.0 Fitting and adjustment of spectacles and contact lenses
0.643 0.357 0.000
G63.2 Diabetic polyneuropathy
0.643 0.357 0.000
S91 Open wound of ankle and foot
0.642 0.357 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.642 0.358 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.642 0.358 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.642 0.358 0.000
M80-M85 Disorders of bone density and structure
0.642 0.358 0.000
G70-G73 Diseases of myoneural junction and muscle
0.641 0.358 0.000
J11 Influenza, virus not identified
0.641 0.359 0.000
Z92.0 Personal history of contraception
0.641 0.359 0.000
R02 Gangrene, not elsewhere classified
0.640 0.360 0.000
S82.5 Fracture of medial malleolus
0.640 0.360 0.000
H53.9 Visual disturbance, unspecified
0.640 0.360 0.000
Z88.7 Personal history of allergy to serum and vaccine
0.639 0.360 0.000
J69 Pneumonitis due to solids and liquids
0.639 0.360 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.639 0.361 0.000
C15-C26 Malignant neoplasms of digestive organs
0.639 0.361 0.000
W46 Contact with hypodermic needle
0.639 0.361 0.000
W45 Foreign body or object entering through skin
0.639 0.361 0.000
W43 Exposure to vibration
0.639 0.361 0.000
W42 Exposure to noise
0.639 0.361 0.000
W41 Exposure to high-pressure jet
0.639 0.361 0.000
W40 Explosion of other materials
0.639 0.361 0.000
W39 Discharge of firework
0.639 0.361 0.000
W38 Explosion and rupture of other specified pressurised devices
0.639 0.361 0.000
W37 Explosion and rupture of pressurised tyre, pipe or hose
0.639 0.361 0.000
W36 Explosion and rupture of gas cylinder
0.639 0.361 0.000
W35 Explosion and rupture of boiler
0.639 0.361 0.000
W34 Discharge from other and unspecified firearms
0.639 0.361 0.000
W33 Rifle, shotgun and larger firearm discharge
0.639 0.361 0.000
W32 Handgun discharge
0.639 0.361 0.000
W31 Contact with other and unspecified machinery
0.639 0.361 0.000
W30 Contact with agricultural machinery
0.639 0.361 0.000
W28 Contact with powered lawn mower
0.639 0.361 0.000
W27 Contact with nonpowered hand tool
0.639 0.361 0.000
W26 Contact with knife, sword or dagger
0.639 0.361 0.000
W24 Contact with lifting and transmission devices, not elsewhere classified
0.639 0.361 0.000
W23 Caught, crushed, jammed or pinched in or between objects
0.639 0.361 0.000
W20 Struck by thrown, projected or falling object
0.639 0.361 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.639 0.361 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.639 0.361 0.000
S48 Traumatic amputation of shoulder and upper arm
0.639 0.361 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.639 0.361 0.000
S44 Injury of nerves at shoulder and upper arm level
0.639 0.361 0.000
S47 Crushing injury of shoulder and upper arm
0.639 0.361 0.000
A41.9 Septicaemia, unspecified
0.639 0.361 0.000
S72.1 Pertrochanteric fracture
0.638 0.361 0.000
S70 Superficial injury of hip and thigh
0.638 0.362 0.000
G43 Migraine
0.638 0.362 0.000
T86.0 Bone-marrow transplant rejection
0.637 0.362 0.000
J06.9 Acute upper respiratory infection, unspecified
0.637 0.363 0.000
R61 Hyperhidrosis
0.637 0.363 0.000
R00.2 Palpitations
0.637 0.363 0.000
T75 Effects of other external causes
0.637 0.363 0.000
T74 Maltreatment syndromes
0.637 0.363 0.000
T73 Effects of other deprivation
0.637 0.363 0.000
T70 Effects of air pressure and water pressure
0.637 0.363 0.000
T69 Other effects of reduced temperature
0.637 0.363 0.000
T67 Effects of heat and light
0.637 0.363 0.000
T71 Asphyxiation
0.637 0.363 0.000
T66 Unspecified effects of radiation
0.637 0.363 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.637 0.363 0.000
H57 Other disorders of eye and adnexa
0.637 0.363 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.636 0.363 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.636 0.364 0.000
H20 Iridocyclitis
0.636 0.364 0.000
H55 Nystagmus and other irregular eye movements
0.636 0.364 0.000
J86 Pyothorax
0.636 0.364 0.000
S82.1 Fracture of upper end of tibia
0.636 0.364 0.000
J98.9 Respiratory disorder, unspecified
0.636 0.364 0.000
S72.9 Fracture of femur, part unspecified
0.635 0.365 0.000
S72.8 Fractures of other parts of femur
0.635 0.365 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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