TreeWAS – Variant ID: rs1320448

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	No effect posterior probability	Protective posterior probability
# Top node	0.507	0.493
Chapter IX Diseases of the circulatory system	0.515	0.485
Chapter IV Endocrine, nutritional and metabolic diseases	0.524	0.476
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.526	0.474
I20-I25 Ischaemic heart diseases	0.531	0.469
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.532	0.468
I10-I15 Hypertensive diseases	0.547	0.453
R30-R39 Symptoms and signs involving the urinary system	0.549	0.451
R31 Unspecified haematuria	0.556	0.444
I20 Angina pectoris	0.557	0.443
Chapter XV Pregnancy, childbirth and the puerperium	0.565	0.435
I10 Essential (primary) hypertension	0.570	0.430
M20-M25 Other joint disorders	0.571	0.429
E70-E90 Metabolic disorders	0.575	0.425
Chapter V Mental and behavioural disorders	0.576	0.424
E00-E07 Disorders of thyroid gland	0.577	0.423
I25 Chronic ischaemic heart disease	0.581	0.419
I20.9 Angina pectoris, unspecified	0.589	0.411
Chapter XIV Diseases of the genitourinary system	0.593	0.407
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.593	0.407
R50-R69 General symptoms and signs	0.593	0.407
Chapter VIII Diseases of the ear and mastoid process	0.594	0.406
M50-M54 Other dorsopathies	0.596	0.404
N30-N39 Other diseases of urinary system	0.600	0.400
E78.0 Pure hypercholesterolaemia	0.601	0.399
I70-I79 Diseases of arteries, arterioles and capillaries	0.605	0.395
M05-M14 Inflammatory polyarthropathies	0.612	0.388
E65-E68 Obesity and other hyperalimentation	0.614	0.386
I20.0 Unstable angina	0.615	0.385
M20 Acquired deformities of fingers and toes	0.620	0.380
R69 Unknown and unspecified causes of morbidity	0.623	0.377
M15-M19 Arthrosis	0.623	0.377
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.625	0.375
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.626	0.374
I95-I99 Other and unspecified disorders of the circulatory system	0.628	0.372
Chapter XI Diseases of the digestive system	0.628	0.372
N39 Other disorders of urinary system	0.631	0.368
E10-E14 Diabetes mellitus	0.632	0.368
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.634	0.366
I05-I09 Chronic rheumatic heart diseases	0.636	0.364
N32 Other disorders of bladder	0.639	0.361
E03 Other hypothyroidism	0.639	0.361
I22 Subsequent myocardial infarction	0.642	0.358
O60-O75 Complications of labour and delivery	0.643	0.357
I25.1 Atherosclerotic heart disease	0.643	0.357
M91-M94 Chondropathies	0.644	0.356
E50-E64 Other nutritional deficiencies	0.644	0.356
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.646	0.354
Chapter XVI Certain conditions originating in the perinatal period	0.646	0.354
Chapter VI Diseases of the nervous system	0.647	0.352
R35 Polyuria	0.652	0.348
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.652	0.348
M65-M68 Disorders of synovium and tendon	0.652	0.348
I00-I02 Acute rheumatic fever	0.653	0.347
R47-R49 Symptoms and signs involving speech and voice	0.653	0.347
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.654	0.346
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.655	0.345
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.655	0.345
M80-M85 Disorders of bone density and structure	0.656	0.344
M00-M03 Infectious arthropathies	0.656	0.344
M19 Other arthrosis	0.656	0.344
Chapter II Neoplasms	0.657	0.343
I25.2 Old myocardial infarction	0.658	0.342
Chapter XXII Codes for special purposes	0.658	0.342
M60-M63 Disorders of muscles	0.658	0.342
R39 Other symptoms and signs involving the urinary system	0.659	0.341
M86-M90 Other osteopathies	0.659	0.341
F30-F39 Mood [affective] disorders	0.661	0.339
E40-E46 Malnutrition	0.663	0.336
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.665	0.335
I23 Certain current complications following acute myocardial infarction	0.665	0.335
R95-R99 Ill-defined and unknown causes of mortality	0.665	0.335
I12 Hypertensive renal disease	0.666	0.334
R50 Fever of unknown origin	0.668	0.332
R34 Anuria and oliguria	0.668	0.331
K20-K31 Diseases of oesophagus, stomach and duodenum	0.669	0.331
M40-M43 Deforming dorsopathies	0.669	0.331
Chapter XX External causes of morbidity and mortality	0.669	0.331
H90-H95 Other disorders of ear	0.670	0.330
M35 Other systemic involvement of connective tissue	0.671	0.329
I25.8 Other forms of chronic ischaemic heart disease	0.671	0.329
N35 Urethral stricture	0.671	0.328
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.672	0.328
M20.4 Other hammer toe(s) (acquired)	0.672	0.328
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.673	0.327
I60-I69 Cerebrovascular diseases	0.673	0.327
M34 Systemic sclerosis	0.674	0.326
M45-M49 Spondylopathies	0.675	0.325
R59 Enlarged lymph nodes	0.676	0.324
E05 Thyrotoxicosis [hyperthyroidism]	0.676	0.324
R07 Pain in throat and chest	0.676	0.324
I13 Hypertensive heart and renal disease	0.676	0.324
E66 Obesity	0.676	0.324
M22 Disorders of patella	0.677	0.323
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.678	0.322
R36 Urethral discharge	0.678	0.322
O94-O99 Other obstetric conditions, not elsewhere classified	0.678	0.322
M25 Other joint disorders, not elsewhere classified	0.678	0.322
O80-O84 Delivery	0.678	0.322
M50 Cervical disk disorders	0.679	0.321
M19.9 Arthrosis, unspecified	0.680	0.320
E04 Other non-toxic goitre	0.680	0.320
I15 Secondary hypertension	0.680	0.319
T36-T50 Poisoning by drugs, medicaments and biological substances	0.681	0.319
N32.0 Bladder-neck obstruction	0.681	0.319
I24 Other acute ischaemic heart diseases	0.681	0.318
I11 Hypertensive heart disease	0.682	0.318
M51 Other intervertebral disk disorders	0.682	0.318
I78 Diseases of capillaries	0.682	0.318
M20.1 Hallux valgus (acquired)	0.682	0.318
M21 Other acquired deformities of limbs	0.682	0.318
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.682	0.318
N31 Neuromuscular dysfunction of bladder, not elsewhere classified	0.683	0.317
R32 Unspecified urinary incontinence	0.683	0.317
N39.0 Urinary tract infection, site not specified	0.684	0.316
F99-F99 Unspecified mental disorder	0.684	0.316
M54 Dorsalgia	0.685	0.315
I21 Acute myocardial infarction	0.685	0.315
E02 Subclinical iodine-deficiency hypothyroidism	0.685	0.314
E03.9 Hypothyroidism, unspecified	0.686	0.314
E10 Insulin-dependent diabetes mellitus	0.686	0.314
M06 Other rheumatoid arthritis	0.686	0.313
M24 Other specific joint derangements	0.686	0.313
E79 Disorders of purine and pyrimidine metabolism	0.687	0.313
I73 Other peripheral vascular diseases	0.687	0.313
K22 Other diseases of oesophagus	0.688	0.312
R53 Malaise and fatigue	0.688	0.312
E80 Disorders of porphyrin and bilirubin metabolism	0.690	0.310
H65-H75 Diseases of middle ear and mastoid	0.690	0.310
K90-K93 Other diseases of the digestive system	0.691	0.309
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.691	0.309
E07 Other disorders of thyroid	0.691	0.308
I20.1 Angina pectoris with documented spasm	0.692	0.307
Chapter VII Diseases of the eye and adnexa	0.692	0.307
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.693	0.307
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.693	0.307
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.693	0.307
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.693	0.307
F60-F69 Disorders of adult personality and behaviour	0.694	0.306
M32 Systemic lupus erythematosus	0.694	0.306
E83 Disorders of mineral metabolism	0.695	0.305
E76 Disorders of glycosaminoglycan metabolism	0.695	0.305
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.695	0.305
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.695	0.305
M30 Polyarteritis nodosa and related conditions	0.695	0.305
E77 Disorders of glycoprotein metabolism	0.695	0.305
E70 Disorders of aromatic amino-acid metabolism	0.695	0.304
M33 Dermatopolymyositis	0.695	0.304
E20-E35 Disorders of other endocrine glands	0.695	0.304
E72 Other disorders of amino-acid metabolism	0.696	0.304
E84 Cystic fibrosis	0.696	0.304
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.696	0.304
O85-O92 Complications predominantly related to the puerperium	0.696	0.304
F80-F89 Disorders of psychological development	0.696	0.304
M13 Other arthritis	0.696	0.304
E88 Other metabolic disorders	0.696	0.304
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.696	0.304
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.697	0.303
E00 Congenital iodine-deficiency syndrome	0.697	0.303
E06 Thyroiditis	0.697	0.303
F70-F79 Mental retardation	0.697	0.303
E74 Other disorders of carbohydrate metabolism	0.697	0.303
E73 Lactose intolerance	0.698	0.302
I25.9 Chronic ischaemic heart disease, unspecified	0.699	0.301
I30-I52 Other forms of heart disease	0.699	0.301
H60-H62 Diseases of external ear	0.699	0.301
I25.6 Silent myocardial ischaemia	0.700	0.300
E85 Amyloidosis	0.700	0.300
R58 Haemorrhage, not elsewhere classified	0.700	0.300
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.700	0.300
R04 Haemorrhage from respiratory passages	0.702	0.298
I25.4 Coronary artery aneurysm	0.702	0.298
N32.9 Bladder disorder, unspecified	0.702	0.298
I25.0 Atherosclerotic cardiovascular disease, so described	0.702	0.298
R54 Senility	0.704	0.296
M31 Other necrotising vasculopathies	0.704	0.296
N99-N99 Other disorders of the genitourinary system	0.704	0.296
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.705	0.295
D10-D36 Benign neoplasms	0.705	0.295
I25.3 Aneurysm of heart	0.705	0.295
R00 Abnormalities of heart beat	0.705	0.295
I95 Hypotension	0.706	0.294
F00-F09 Organic, including symptomatic, mental disorders	0.706	0.294
O00-O08 Pregnancy with abortive outcome	0.707	0.293
R30 Pain associated with micturition	0.707	0.293
N25-N29 Other disorders of kidney and ureter	0.707	0.293
N39.4 Other specified urinary incontinence	0.707	0.293
R57 Shock, not elsewhere classified	0.708	0.292
I70 Atherosclerosis	0.708	0.292
E78.3 Hyperchylomicronaemia	0.708	0.291
R62 Lack of expected normal physiological development	0.708	0.292
C43-C44 Melanoma and other malignant neoplasms of skin	0.709	0.291
K35-K38 Diseases of appendix	0.709	0.291
E78.6 Lipoprotein deficiency	0.709	0.291
I25.5 Ischaemic cardiomyopathy	0.709	0.291
M07 Psoriatic and enteropathic arthropathies	0.709	0.291
N00-N08 Glomerular diseases	0.709	0.291
R61 Hyperhidrosis	0.709	0.290
M19.99 Arthrosis, unspecified (Site unspecified)	0.710	0.290
O42 Premature rupture of membranes	0.710	0.290
R65 Systemic Inflammatory Response Syndrome [SIRS]	0.710	0.290
N34 Urethritis and urethral syndrome	0.710	0.290
I20.8 Other forms of angina pectoris	0.710	0.290
R64 Cachexia	0.710	0.290
E78.1 Pure hyperglyceridaemia	0.710	0.290
R52 Pain, not elsewhere classified	0.710	0.289
N60-N64 Disorders of breast	0.711	0.289
E78.4 Other hyperlipidaemia	0.711	0.289
I77 Other disorders of arteries and arterioles	0.712	0.288
R41 Other symptoms and signs involving cognitive functions and awareness	0.713	0.287
E78.8 Other disorders of lipoprotein metabolism	0.713	0.287
F32 Depressive episode	0.713	0.287
N37 Urethral disorders in diseases classified elsewhere	0.713	0.287
N33 Bladder disorders in diseases classified elsewhere	0.713	0.287
N39.8 Other specified disorders of urinary system	0.713	0.287
F40-F48 Neurotic, stress-related and somatoform disorders	0.714	0.286
M20.3 Other deformity of hallux (acquired)	0.714	0.286
R51 Headache	0.714	0.286
E78.2 Mixed hyperlipidaemia	0.714	0.286
R07.4 Chest pain, unspecified	0.715	0.285
K70-K77 Diseases of liver	0.715	0.285
I72 Other aneurysm	0.715	0.285
M53 Other dorsopathies, not elsewhere classified	0.716	0.284
M05 Seropositive rheumatoid arthritis	0.716	0.284
E78.9 Disorder of lipoprotein metabolism, unspecified	0.717	0.283
N39.9 Disorder of urinary system, unspecified	0.717	0.283
K40-K46 Hernia	0.718	0.282
H80-H83 Diseases of inner ear	0.718	0.282
N17-N19 Renal failure	0.718	0.282
N20-N23 Urolithiasis	0.718	0.282
K22.8 Other specified diseases of oesophagus	0.718	0.282
T15-T19 Effects of foreign body entering through natural orifice	0.718	0.281
O68 Labour and delivery complicated by foetal stress [distress]	0.718	0.281
M20.6 Acquired deformity of toe(s), unspecified	0.719	0.281
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.719	0.281
O44 Placenta praevia	0.719	0.280
M23 Internal derangement of knee	0.720	0.280
R63 Symptoms and signs concerning food and fluid intake	0.720	0.280
S40-S49 Injuries to the shoulder and upper arm	0.720	0.280
S60-S69 Injuries to the wrist and hand	0.720	0.280
R68 Other general symptoms and signs	0.720	0.280
C51-C58 Malignant neoplasms of female genital organs	0.720	0.280
O47 False labour	0.720	0.280
O32 Maternal care for known or suspected malpresentation of foetus	0.721	0.279
N36 Other disorders of urethra	0.721	0.279
I74 Arterial embolism and thrombosis	0.721	0.279
M09 Juvenile arthritis in diseases classified elsewhere	0.722	0.278
O41 Other disorders of amniotic fluid and membranes	0.722	0.278
M70-M79 Other soft tissue disorders	0.722	0.278
M08 Juvenile arthritis	0.722	0.278
M11 Other crystal arthropathies	0.723	0.277
E67 Other hyperalimentation	0.723	0.277
E68 Sequelae of hyperalimentation	0.723	0.277
K31 Other diseases of stomach and duodenum	0.723	0.277
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.723	0.277
M12 Other specific arthropathies	0.723	0.276
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.724	0.276
C60-C63 Malignant neoplasms of male genital organs	0.724	0.276
O20-O29 Other maternal disorders predominantly related to pregnancy	0.724	0.276
M14 Arthropathies in other diseases classified elsewhere	0.725	0.275
E66.9 Obesity, unspecified	0.725	0.275
I98 Other disorders of circulatory system in diseases classified elsewhere	0.725	0.275
I08 Multiple valve diseases	0.725	0.275
G30-G32 Other degenerative diseases of the nervous system	0.725	0.275
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.725	0.275
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.725	0.275
E13 Other specified diabetes mellitus	0.725	0.274
F17 Mental and behavioural disorders due to use of tobacco	0.726	0.274
T00-T07 Injuries involving multiple body regions	0.726	0.274
M15 Polyarthrosis	0.726	0.274
R39.1 Other difficulties with micturition	0.726	0.274
E65 Localised adiposity	0.726	0.273
N39.3 Stress incontinence	0.726	0.273
F10 Mental and behavioural disorders due to use of alcohol	0.727	0.273
N35.9 Urethral stricture, unspecified	0.727	0.273
O70 Perineal laceration during delivery	0.727	0.273
Chapter XII Diseases of the skin and subcutaneous tissue	0.727	0.273
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.727	0.273
O63 Long labour	0.727	0.273
S00-S09 Injuries to the head	0.728	0.272
E78.5 Hyperlipidaemia, unspecified	0.728	0.271
I22.9 Subsequent myocardial infarction of unspecified site	0.728	0.271
R50.9 Fever, unspecified	0.729	0.271
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.729	0.271
T79-T79 Certain early complications of trauma	0.730	0.270
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.730	0.270
H92 Otalgia and effusion of ear	0.730	0.270
N32.8 Other specified disorders of bladder	0.730	0.270
K30 Dyspepsia	0.730	0.270
K92 Other diseases of digestive system	0.730	0.269
G40-G47 Episodic and paroxysmal disorders	0.731	0.269
E87 Other disorders of fluid, electrolyte and acid-base balance	0.731	0.269
O40 Polyhydramnios	0.731	0.269
I07 Rheumatic tricuspid valve diseases	0.731	0.269
O34 Maternal care for known or suspected abnormality of pelvic organs	0.731	0.269
T33-T35 Frostbite	0.732	0.268
T26-T28 Burns and corrosions confined to eye and internal organs	0.732	0.268
O72 Postpartum haemorrhage	0.732	0.268
M92 Other juvenile osteochondrosis	0.732	0.267
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.733	0.267
M20.5 Other deformities of toe(s) (acquired)	0.733	0.267
Chapter I Certain infectious and parasitic diseases	0.733	0.266
E03.8 Other specified hypothyroidism	0.734	0.266
O16 Unspecified maternal hypertension	0.734	0.266
T20-T25 Burns and corrosions of external body surface, specified by site	0.734	0.266
E53 Deficiency of other B group vitamins	0.734	0.266
M91 Juvenile osteochondrosis of hip and pelvis	0.734	0.266
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.734	0.266
S70-S79 Injuries to the hip and thigh	0.735	0.265
Chapter X Diseases of the respiratory system	0.735	0.265
C15-C26 Malignant neoplasms of digestive organs	0.735	0.265
K22.1 Ulcer of oesophagus	0.735	0.264
N39.2 Orthostatic proteinuria, unspecified	0.736	0.264
O43 Placental disorders	0.736	0.264
I22.0 Subsequent myocardial infarction of anterior wall	0.736	0.264
E12 Malnutrition-related diabetes mellitus	0.736	0.264
N30 Cystitis	0.736	0.263
O35 Maternal care for known or suspected foetal abnormality and damage	0.737	0.263
O30 Multiple gestation	0.737	0.263
N39.1 Persistent proteinuria, unspecified	0.737	0.263
O66 Other obstructed labour	0.737	0.263
S50-S59 Injuries to the elbow and forearm	0.737	0.263
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.737	0.263
M20.0 Deformity of finger(s)	0.737	0.263
N70-N77 Inflammatory diseases of female pelvic organs	0.737	0.263
R10-R19 Symptoms and signs involving the digestive system and abdomen	0.737	0.262
E05.0 Thyrotoxicosis with diffuse goitre	0.738	0.262
M18 Arthrosis of first carpometacarpal joint	0.738	0.262
K21 Gastro-oesophageal reflux disease	0.738	0.262
E10.9 Without complications	0.738	0.262
O31 Complications specific to multiple gestation	0.738	0.262
O45 Premature separation of placenta [abruptio placentae]	0.738	0.261
I99 Other and unspecified disorders of circulatory system	0.738	0.261
O64 Obstructed labour due to malposition and malpresentation of foetus	0.738	0.261
O33 Maternal care for known or suspected disproportion	0.739	0.261
I71 Aortic aneurysm and dissection	0.739	0.261
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.739	0.261
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.739	0.261
I22.1 Subsequent myocardial infarction of inferior wall	0.739	0.261
O46 Antepartum haemorrhage, not elsewhere classified	0.739	0.260
R56 Convulsions, not elsewhere classified	0.740	0.260
I09 Other rheumatic heart diseases	0.740	0.260
E55 Vitamin D deficiency	0.740	0.260
R45 Symptoms and signs involving emotional state	0.740	0.260
O61 Failed induction of labour	0.740	0.260
G20-G26 Extrapyramidal and movement disorders	0.740	0.260
I06 Rheumatic aortic valve diseases	0.740	0.260
R42 Dizziness and giddiness	0.740	0.260
M66 Spontaneous rupture of synovium and tendon	0.740	0.260
K65-K67 Diseases of peritoneum	0.740	0.260
M19.2 Other secondary arthrosis	0.741	0.259
R07.2 Precordial pain	0.741	0.259
E03.5 Myxoedema coma	0.741	0.259
E03.4 Atrophy of thyroid (acquired)	0.741	0.259
E03.3 Postinfectious hypothyroidism	0.741	0.259
N32.4 Rupture of bladder, nontraumatic	0.741	0.259
O71 Other obstetric trauma	0.741	0.259
M54.3 Sciatica	0.741	0.259
R59.9 Enlarged lymph nodes, unspecified	0.741	0.259
I05 Rheumatic mitral valve diseases	0.741	0.258
E03.0 Congenital hypothyroidism with diffuse goitre	0.741	0.258
R47 Speech disturbances, not elsewhere classified	0.741	0.258
E03.1 Congenital hypothyroidism without goitre	0.741	0.258
N32.2 Vesical fistula, not elsewhere classified	0.742	0.258
N10-N16 Renal tubulo-interstitial diseases	0.742	0.258
R02 Gangrene, not elsewhere classified	0.742	0.258
M06.9 Rheumatoid arthritis, unspecified	0.742	0.258
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.742	0.258
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.742	0.257
F52 Sexual dysfunction, not caused by organic disorder or disease	0.743	0.257
E61 Deficiency of other nutrient elements	0.743	0.256
R60 Oedema, not elsewhere classified	0.743	0.256
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.743	0.256
O60 Preterm delivery	0.744	0.256
R50.0 Fever with chills	0.744	0.256
O74 Complications of anaesthesia during labour and delivery	0.744	0.256
E64 Sequelae of malnutrition and other nutritional deficiencies	0.744	0.255
E50 Vitamin A deficiency	0.744	0.255
E60 Dietary zinc deficiency	0.744	0.255
E59 Dietary selenium deficiency	0.744	0.255
E52 Niacin deficiency [pellagra]	0.744	0.255
E63 Other nutritional deficiencies	0.745	0.255
O65 Obstructed labour due to maternal pelvic abnormality	0.745	0.255
E54 Ascorbic acid deficiency	0.745	0.255
E56 Other vitamin deficiencies	0.745	0.255
E51 Thiamine deficiency	0.745	0.255
E58 Dietary calcium deficiency	0.745	0.255
M84 Disorders of continuity of bone	0.745	0.255
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.745	0.254
R01 Cardiac murmurs and other cardiac sounds	0.746	0.254
M10 Gout	0.746	0.254
D17 Benign lipomatous neoplasm	0.746	0.254
M19.1 Posttraumatic arthrosis of other joints	0.746	0.254
I22.8 Subsequent myocardial infarction of other sites	0.746	0.254
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.746	0.254
N32.1 Vesicointestinal fistula	0.746	0.254
M99 Biomechanical lesions, not elsewhere classified	0.746	0.254
P90-P96 Other disorders originating in the perinatal period	0.746	0.254
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn	0.746	0.254
P75-P78 Digestive system disorders of fetus and newborn	0.746	0.254
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn	0.746	0.254
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn	0.746	0.254
P35-P39 Infections specific to the perinatal period	0.746	0.254
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period	0.746	0.254
P05-P08 Disorders related to length of gestation and fetal growth	0.746	0.254
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery	0.746	0.254
P10-P15 Birth trauma	0.746	0.253
T66-T78 Other and unspecified effects of external causes	0.746	0.253
M25.7 Osteophyte	0.746	0.253
E16 Other disorders of pancreatic internal secretion	0.747	0.253
S10-S19 Injuries to the neck	0.747	0.253
G70-G73 Diseases of myoneural junction and muscle	0.747	0.253
R03 Abnormal blood-pressure reading, without diagnosis	0.747	0.253
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.747	0.253
M35.3 Polymyalgia rheumatica	0.747	0.253
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.747	0.252
S90-S99 Injuries to the ankle and foot	0.747	0.252
M94 Other disorders of cartilage	0.748	0.252
M93 Other osteochondropathies	0.748	0.252
M22.2 Patellofemoral disorders	0.748	0.252
M00 Pyogenic arthritis	0.748	0.252
W20-W49 Exposure to inanimate mechanical forces	0.748	0.252
R43 Disturbances of smell and taste	0.748	0.251
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.748	0.251
M19.97 Arthrosis, unspecified (Ankle and foot)	0.748	0.251
R49 Voice disturbances	0.749	0.251
M51.2 Other specified intervertebral disk displacement	0.749	0.251
O48 Prolonged pregnancy	0.749	0.251
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.749	0.251
M67 Other disorders of synovium and tendon	0.749	0.250
M85 Other disorders of bone density and structure	0.749	0.250
O73 Retained placenta and membranes, without haemorrhage	0.749	0.250
M89 Other disorders of bone	0.750	0.250
E04.1 Non-toxic single thyroid nodule	0.750	0.250
M90 Osteopathies in diseases classified elsewhere	0.750	0.250
S80-S89 Injuries to the knee and lower leg	0.750	0.250
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.750	0.250
R46 Symptoms and signs involving appearance and behaviour	0.750	0.250
M62 Other disorders of muscle	0.751	0.249
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.751	0.249
I02 Rheumatic chorea	0.751	0.249
I01 Rheumatic fever with heart involvement	0.751	0.249
H93 Other disorders of ear, not elsewhere classified	0.751	0.249
R41.0 Disorientation, unspecified	0.751	0.249
M13.9 Arthritis, unspecified	0.751	0.249
E15 Nondiabetic hypoglycaemic coma	0.751	0.248
I00 Rheumatic fever without mention of heart involvement	0.751	0.248
I73.0 Raynaud's syndrome	0.751	0.248
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified	0.751	0.248
M34.9 Systemic sclerosis, unspecified	0.752	0.248
N32.3 Diverticulum of bladder	0.752	0.248
M81 Osteoporosis without pathological fracture	0.752	0.247
O69 Labour and delivery complicated by umbilical cord complications	0.752	0.247
R20 Disturbances of skin sensation	0.752	0.247
I12.0 Hypertensive renal disease with renal failure	0.752	0.247
F18 Mental and behavioural disorders due to use of volatile solvents	0.753	0.247
F16 Mental and behavioural disorders due to use of hallucinogens	0.753	0.247
O15 Eclampsia	0.753	0.247
I69 Sequelae of cerebrovascular disease	0.753	0.247
M19.93 Arthrosis, unspecified (Forearm)	0.753	0.247
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.753	0.247
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.753	0.247
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.753	0.247
F14 Mental and behavioural disorders due to use of cocaine	0.753	0.247
H90 Conductive and sensorineural hearing loss	0.753	0.247
M65 Synovitis and tenosynovitis	0.753	0.247
M35.0 Sicca syndrome [Sjogren]	0.753	0.247
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine	0.753	0.246
F13 Mental and behavioural disorders due to use of sedatives or hypnotics	0.753	0.246
M50.2 Other cervical disk displacement	0.753	0.246
M83 Adult osteomalacia	0.754	0.246
M86 Osteomyelitis	0.754	0.246
M02 Reactive arthropathies	0.754	0.246
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.754	0.246
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances	0.754	0.246
M19.8 Other specified arthrosis	0.754	0.246
N31.8 Other neuromuscular dysfunction of bladder	0.754	0.246
I78.1 Naevus, nonneoplastic	0.754	0.245
M19.90 Arthrosis, unspecified (Multiple sites)	0.754	0.246
X40-X49 Accidental poisoning by and exposure to noxious substances	0.754	0.245
R94 Abnormal results of function studies	0.755	0.245
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.755	0.245
R23 Other skin changes	0.755	0.245
M63 Disorders of muscle in diseases classified elsewhere	0.755	0.245
M61 Calcification and ossification of muscle	0.755	0.245
M82 Osteoporosis in diseases classified elsewhere	0.755	0.245
Y60-Y69 Misadventures to patients during surgical and medical care	0.755	0.245
I78.8 Other diseases of capillaries	0.755	0.245
X60-X84 Intentional self-harm	0.755	0.245
I31 Other diseases of pericardium	0.755	0.245
F11 Mental and behavioural disorders due to use of opioids	0.755	0.244
R39.2 Extrarenal uraemia	0.755	0.244
O62 Abnormalities of forces of labour	0.755	0.244
G00-G09 Inflammatory diseases of the central nervous system	0.755	0.244
F33 Recurrent depressive disorder	0.756	0.244
F12 Mental and behavioural disorders due to use of cannabinoids	0.756	0.244
M19.91 Arthrosis, unspecified (Shoulder region)	0.756	0.244
R39.0 Extravasation of urine	0.756	0.244
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.756	0.243
C40-C41 Malignant neoplasms of bone and articular cartilage	0.756	0.243

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations