TreeWAS – Variant ID: rs1429138

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
D12.8 Rectum	0.000	0.941	0.059
M54.56 Low back pain (Lumbar region)	0.054	0.946	0.000
M54.5 Low back pain	0.048	0.952	0.000
M54.57 Low back pain (Lumbosacral region)	0.044	0.956	0.000
M54.59 Low back pain (Site unspecified)	0.044	0.956	0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.037	0.963	0.000
M54.54 Low back pain-Thoracic	0.036	0.964	0.000
M54.53 Low back pain-Cervicothoracic	0.034	0.965	0.000
M54.51 Low back pain-Occipit-atl-axl	0.034	0.965	0.000
M54.52 Low back pain-Cervical	0.034	0.966	0.000
M54.55 Low back pain (Thoracolumbar region)	0.032	0.968	0.000
I30-I52 Other forms of heart disease	0.031	0.969	0.000
I35 Nonrheumatic aortic valve disorders	0.030	0.970	0.000
I38 Endocarditis, valve unspecified	0.030	0.970	0.000
I35.0 Aortic (valve) stenosis	0.030	0.970	0.000
M54.50 Low back pain (Multiple sites in spine)	0.029	0.971	0.000
I30 Acute pericarditis	0.028	0.972	0.000
I42 Cardiomyopathy	0.027	0.973	0.000
I51 Complications and ill-defined descriptions of heart disease	0.027	0.973	0.000
I31 Other diseases of pericardium	0.027	0.973	0.000
I36 Nonrheumatic tricuspid valve disorders	0.025	0.975	0.000
I35.8 Other aortic valve disorders	0.025	0.975	0.000
I45 Other conduction disorders	0.025	0.975	0.000
T39.1 4-Aminophenol derivatives	0.000	0.975	0.025
I30.9 Acute pericarditis, unspecified	0.025	0.975	0.000
I33 Acute and subacute endocarditis	0.024	0.976	0.000
I50 Heart failure	0.024	0.976	0.000
I35.9 Aortic valve disorder, unspecified	0.023	0.977	0.000
I46 Cardiac arrest	0.023	0.977	0.000
I31.9 Disease of pericardium, unspecified	0.023	0.977	0.000
I51.7 Cardiomegaly	0.023	0.977	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.023	0.977	0.000
I51.8 Other ill-defined heart diseases	0.023	0.977	0.000
I52 Other heart disorders in diseases classified elsewhere	0.022	0.977	0.000
I48 Atrial fibrillation and flutter	0.022	0.977	0.000
I41 Myocarditis in diseases classified elsewhere	0.022	0.977	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.022	0.977	0.000
I32 Pericarditis in diseases classified elsewhere	0.022	0.977	0.000
I51.9 Heart disease, unspecified	0.022	0.978	0.000
I35.2 Aortic (valve) stenosis with insufficiency	0.022	0.978	0.000
I42.6 Alcoholic cardiomyopathy	0.022	0.978	0.000
I30.1 Infective pericarditis	0.022	0.978	0.000
I40 Acute myocarditis	0.022	0.978	0.000
I37 Pulmonary valve disorders	0.022	0.978	0.000
I42.0 Dilated cardiomyopathy	0.022	0.978	0.000
I42.8 Other cardiomyopathies	0.021	0.978	0.000
I45.5 Other specified heart block	0.021	0.979	0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency	0.021	0.979	0.000
I31.3 Pericardial effusion (noninflammatory)	0.021	0.979	0.000
I45.6 Preexcitation syndrome	0.021	0.979	0.000
I31.0 Chronic adhesive pericarditis	0.021	0.979	0.000
I49 Other cardiac arrhythmias	0.021	0.979	0.000
I51.6 Cardiovascular disease, unspecified	0.021	0.979	0.000
I42.2 Other hypertrophic cardiomyopathy	0.021	0.979	0.000
I51.3 Intracardiac thrombosis, not elsewhere classified	0.020	0.979	0.000
I30.8 Other forms of acute pericarditis	0.020	0.979	0.000
I42.7 Cardiomyopathy due to drugs and other external agents	0.020	0.979	0.000
I51.5 Myocardial degeneration	0.020	0.980	0.000
I42.4 Endocardial fibroelastosis	0.020	0.980	0.000
I42.5 Other restrictive cardiomyopathy	0.020	0.980	0.000
I30.0 Acute nonspecific idiopathic pericarditis	0.020	0.980	0.000
I31.1 Chronic constrictive pericarditis	0.020	0.980	0.000
I35.1 Aortic (valve) insufficiency	0.020	0.980	0.000
I42.3 Endomyocardial (eosinophilic) disease	0.020	0.980	0.000
I51.2 Rupture of papillary muscle, not elsewhere classified	0.020	0.980	0.000
I31.8 Other specified diseases of pericardium	0.020	0.980	0.000
I31.2 Haemopericardium, not elsewhere classified	0.020	0.980	0.000
I33.0 Acute and subacute infective endocarditis	0.019	0.980	0.000
I42.9 Cardiomyopathy, unspecified	0.019	0.981	0.000
I45.4 Nonspecific intraventricular block	0.019	0.981	0.000
I42.1 Obstructive hypertrophic cardiomyopathy	0.019	0.981	0.000
I51.0 Cardiac septal defect, acquired	0.019	0.981	0.000
I50.1 Left ventricular failure	0.019	0.981	0.000
I45.0 Right fascicular block	0.018	0.981	0.000
I36.9 Nonrheumatic tricuspid valve disorder, unspecified	0.018	0.982	0.000
I36.8 Other nonrheumatic tricuspid valve disorders	0.018	0.982	0.000
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency	0.018	0.982	0.000
I36.0 Nonrheumatic tricuspid (valve) stenosis	0.018	0.982	0.000
I45.3 Trifascicular block	0.018	0.982	0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.018	0.982	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.000	0.982	0.018
I45.2 Bifascicular block	0.018	0.982	0.000
I33.9 Acute endocarditis, unspecified	0.018	0.982	0.000
I49.5 Sick sinus syndrome	0.018	0.982	0.000
I50.0 Congestive heart failure	0.018	0.982	0.000
I50.9 Heart failure, unspecified	0.018	0.982	0.000
I46.9 Cardiac arrest, unspecified	0.017	0.983	0.000
I46.1 Sudden cardiac death, so described	0.017	0.983	0.000
I46.0 Cardiac arrest with successful resuscitation	0.017	0.983	0.000
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere	0.017	0.983	0.000
I43.8 Cardiomyopathy in other diseases classified elsewhere	0.017	0.983	0.000
I49.8 Other specified cardiac arrhythmias	0.017	0.983	0.000
I43.2 Cardiomyopathy in nutritional diseases	0.017	0.983	0.000
I43.1 Cardiomyopathy in metabolic diseases	0.016	0.983	0.000
I49.0 Ventricular fibrillation and flutter	0.017	0.983	0.000
I32.8 Pericarditis in other diseases classified elsewhere	0.016	0.984	0.000
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere	0.016	0.984	0.000
I32.0 Pericarditis in bacterial diseases classified elsewhere	0.016	0.984	0.000
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere	0.016	0.984	0.000
I39.4 Multiple valve disorders in diseases classified elsewhere	0.016	0.984	0.000
I39.3 Pulmonary valve disorders in diseases classified elsewhere	0.016	0.984	0.000
I39.2 Tricuspid valve disorders in diseases classified elsewhere	0.016	0.984	0.000
I39.1 Aortic valve disorders in diseases classified elsewhere	0.016	0.984	0.000
I39.0 Mitral valve disorders in diseases classified elsewhere	0.016	0.984	0.000
I41.8 Myocarditis in other diseases classified elsewhere	0.016	0.984	0.000
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere	0.016	0.984	0.000
I41.1 Myocarditis in viral diseases classified elsewhere	0.016	0.984	0.000
I41.0 Myocarditis in bacterial diseases classified elsewhere	0.016	0.984	0.000
I48.9 Atrial fibrillation and atrial flutter, unspecified	0.016	0.984	0.000
I48.4 Atypical atrial flutter	0.016	0.984	0.000
I48.3 Typical atrial flutter	0.016	0.984	0.000
I48.2 Chronic atrial fibrillation	0.016	0.984	0.000
I48.1 Persistent atrial fibrillation	0.016	0.984	0.000
I48.0 Paroxysmal atrial fibrillation	0.016	0.984	0.000
I52.8 Other heart disorders in other diseases classified elsewhere	0.016	0.984	0.000
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere	0.016	0.984	0.000
I52.0 Other heart disorders in bacterial diseases classified elsewhere	0.016	0.984	0.000
I40.0 Infective myocarditis	0.016	0.984	0.000
T39.0 Salicylates	0.000	0.984	0.016
I40.8 Other acute myocarditis	0.016	0.984	0.000
I40.1 Isolated myocarditis	0.016	0.984	0.000
I45.9 Conduction disorder, unspecified	0.016	0.984	0.000
I37.9 Pulmonary valve disorder, unspecified	0.016	0.984	0.000
I37.8 Other pulmonary valve disorders	0.016	0.984	0.000
I37.2 Pulmonary valve stenosis with insufficiency	0.016	0.984	0.000
I37.0 Pulmonary valve stenosis	0.015	0.984	0.000
I45.8 Other specified conduction disorders	0.015	0.984	0.000
I45.1 Other and unspecified right bundle-branch block	0.015	0.985	0.000
I51.4 Myocarditis, unspecified	0.015	0.985	0.000
I37.1 Pulmonary valve insufficiency	0.015	0.985	0.000
I49.2 Junctional premature depolarisation	0.015	0.985	0.000
I40.9 Acute myocarditis, unspecified	0.015	0.985	0.000
I49.3 Ventricular premature depolarisation	0.015	0.985	0.000
I44 Atrioventricular and left bundle-branch block	0.014	0.986	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.000	0.986	0.014
M54 Dorsalgia	0.014	0.986	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.000	0.986	0.014
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.000	0.987	0.013
T39.4 Antirheumatics, not elsewhere classified	0.000	0.987	0.013
T39.2 Pyrazolone derivatives	0.000	0.987	0.013
I34 Nonrheumatic mitral valve disorders	0.013	0.987	0.000
I49.1 Atrial premature depolarisation	0.013	0.987	0.000
I47 Paroxysmal tachycardia	0.012	0.987	0.000
I44.2 Atrioventricular block, complete	0.012	0.988	0.000
I44.6 Other and unspecified fascicular block	0.011	0.989	0.000
I49.9 Cardiac arrhythmia, unspecified	0.011	0.989	0.000
M54.6 Pain in thoracic spine	0.011	0.989	0.000
M54.2 Cervicalgia	0.011	0.989	0.000
M54.1 Radiculopathy	0.011	0.989	0.000
I44.0 Atrioventricular block, first degree	0.011	0.989	0.000
I34.2 Nonrheumatic mitral (valve) stenosis	0.010	0.989	0.000
I44.5 Left posterior fascicular block	0.010	0.989	0.000
I49.4 Other and unspecified premature depolarisation	0.010	0.989	0.000
M54.0 Panniculitis affecting regions of neck and back	0.010	0.990	0.000
M54.8 Other dorsalgia	0.010	0.990	0.000
I44.3 Other and unspecified atrioventricular block	0.010	0.990	0.000
I47.0 Reentry ventricular arrhythmia	0.010	0.990	0.000
I34.8 Other nonrheumatic mitral valve disorders	0.010	0.990	0.000
I44.4 Left anterior fascicular block	0.009	0.991	0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified	0.009	0.991	0.000
M54.16 Radiculopathy (Lumbar region)	0.009	0.991	0.000
I47.9 Paroxysmal tachycardia, unspecified	0.009	0.991	0.000
M54.9 Dorsalgia, unspecified	0.009	0.991	0.000
M54.64 Pain in thoracic spine (Thoracic region)	0.008	0.991	0.000
M54.23 Cervicalgia (Cervicothoracic region)	0.008	0.991	0.000
M54.14 Radiculopathy (Thoracic region)	0.008	0.992	0.000
M54.28 Cervicalgia-Sacral/sacrococ	0.008	0.992	0.000
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.008	0.992	0.000
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.008	0.992	0.000
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.008	0.992	0.000
M54.29 Cervicalgia-Site unspe	0.008	0.992	0.000
M54.10 Radiculopathy (Multiple sites in spine)	0.008	0.992	0.000
M54.69 Pain in thoracic spine-Site unspe	0.008	0.992	0.000
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.008	0.992	0.000
M54.67 Pain in thoracic spine-Lumbosacral	0.008	0.992	0.000
M54.66 Pain in thoracic spine-Lumbar	0.008	0.992	0.000
M54.62 Pain in thoracic spine-Cervical	0.008	0.992	0.000
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.008	0.992	0.000
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.008	0.992	0.000
M54.13 Radiculopathy (Cervicothoracic region)	0.008	0.992	0.000
M54.27 Cervicalgia-Lumbosacral	0.008	0.992	0.000
M54.26 Cervicalgia-Lumbar	0.008	0.992	0.000
M54.25 Cervicalgia-Thoracolumbar	0.008	0.992	0.000
M54.24 Cervicalgia-Thoracic	0.008	0.992	0.000
M54.20 Cervicalgia-Mult site	0.008	0.992	0.000
I44.1 Atrioventricular block, second degree	0.008	0.992	0.000
M54.4 Lumbago with sciatica	0.008	0.992	0.000
M54.15 Radiculopathy (Thoracolumbar region)	0.008	0.992	0.000
M54.11 Radiculopathy (Occipito-atlanto-axial region)	0.008	0.992	0.000
M54.19 Radiculopathy (Site unspecified)	0.008	0.992	0.000
M54.22 Cervicalgia (Cervical region)	0.008	0.992	0.000
M54.17 Radiculopathy (Lumbosacral region)	0.007	0.992	0.000
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.007	0.992	0.000
M54.09 Panniculitis affecting regions of neck and back (Site unspecified)	0.007	0.992	0.000
M54.08 Panniculitis affecting regions of neck and back (Sacral and sacrococcygeal region)	0.007	0.992	0.000
M54.07 Panniculitis affecting regions of neck and back (Lumbosacral region)	0.007	0.992	0.000
M54.06 Panniculitis affecting regions of neck and back (Lumbar region)	0.007	0.992	0.000
M54.05 Panniculitis affecting regions of neck and back (Thoracolumbar region)	0.007	0.992	0.000
M54.04 Panniculitis affecting regions of neck and back (Thoracic region)	0.007	0.992	0.000
M54.03 Panniculitis affecting regions of neck and back (Cervicothoracic region)	0.007	0.992	0.000
M54.02 Panniculitis affecting regions of neck and back (Cervical region)	0.007	0.992	0.000
M54.01 Panniculitis affecting regions of neck and back (Occipito-atlanto-axial region)	0.007	0.992	0.000
M54.00 Panniculitis affecting regions of neck and back (Multiple sites in spine)	0.007	0.992	0.000
M54.12 Radiculopathy (Cervical region)	0.007	0.993	0.000
M54.80 Other dorsalgia (Multiple sites in spine)	0.007	0.993	0.000
M54.88 Other dorsalgia (Sacral and sacrococcygeal region)	0.007	0.993	0.000
M54.87 Other dorsalgia (Lumbosacral region)	0.007	0.993	0.000
M54.86 Other dorsalgia (Lumbar region)	0.007	0.993	0.000
M54.85 Other dorsalgia (Thoracolumbar region)	0.007	0.993	0.000
M54.83 Other dorsalgia (Cervicothoracic region)	0.007	0.993	0.000
M54.82 Other dorsalgia (Cervical region)	0.007	0.993	0.000
M54.81 Other dorsalgia (Occipito-atlanto-axial region)	0.007	0.993	0.000
M54.3 Sciatica	0.007	0.993	0.000
M54.94 Dorsalgia, unspecified (Thoracic region)	0.007	0.993	0.000
M54.96 Dorsalgia, unspecified (Lumbar region)	0.007	0.993	0.000
M54.84 Other dorsalgia (Thoracic region)	0.007	0.993	0.000
I34.1 Mitral (valve) prolapse	0.007	0.993	0.000
K60.3 Anal fistula	0.000	0.993	0.007
M54.89 Other dorsalgia (Site unspecified)	0.007	0.993	0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.007	0.993	0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)	0.007	0.993	0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.007	0.993	0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.006	0.993	0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.006	0.994	0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.006	0.994	0.000
M54.92 Dorsalgia, unspecified (Cervical region)	0.006	0.994	0.000
M54.49 Lumbago with sciatica (Site unspecified)	0.006	0.994	0.000
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.006	0.994	0.000
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.006	0.994	0.000
M54.44 Lumbago with sciatica-Thoracic	0.006	0.994	0.000
M54.43 Lumbago with sciatica-Cervicothoracic	0.006	0.994	0.000
M54.42 Lumbago with sciatica-Cervical	0.006	0.994	0.000
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.006	0.994	0.000
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.006	0.994	0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters	0.000	0.994	0.006
I47.1 Supraventricular tachycardia	0.006	0.994	0.000
I47.2 Ventricular tachycardia	0.005	0.994	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.000	0.994	0.006
M54.47 Lumbago with sciatica (Lumbosacral region)	0.005	0.994	0.000
M54.35 Sciatica (Thoracolumbar region)	0.005	0.994	0.000
M54.34 Sciatica-Thoracic	0.005	0.994	0.000
M54.33 Sciatica-Cervicothoracic	0.005	0.994	0.000
M54.32 Sciatica-Cervical	0.005	0.994	0.000
M54.31 Sciatica-Occipit-atl-axl	0.005	0.994	0.000
M54.30 Sciatica (Multiple sites in spine)	0.005	0.995	0.000
F31.9 Bipolar affective disorder, unspecified	0.005	0.995	0.000
M54.36 Sciatica (Lumbar region)	0.005	0.995	0.000
M54.37 Sciatica (Lumbosacral region)	0.005	0.995	0.000
T43.2 Other and unspecified antidepressants	0.000	0.995	0.005
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.000	0.995	0.005
T36 Poisoning by systemic antibiotics	0.000	0.995	0.005
I08.1 Disorders of both mitral and tricuspid valves	0.005	0.995	0.000
M54.39 Sciatica (Site unspecified)	0.005	0.995	0.000
M54.38 Sciatica (Sacral and sacrococcygeal region)	0.004	0.995	0.000
I08 Multiple valve diseases	0.005	0.995	0.000
F31 Bipolar affective disorder	0.005	0.995	0.000
I34.0 Mitral (valve) insufficiency	0.005	0.995	0.000
M54.46 Lumbago with sciatica (Lumbar region)	0.004	0.995	0.000
M11.26 Other chondrocalcinosis (Lower leg)	0.000	0.995	0.005
I05-I09 Chronic rheumatic heart diseases	0.005	0.995	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.000	0.996	0.004
F31.0 Bipolar affective disorder, current episode hypomanic	0.004	0.996	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.000	0.996	0.004
K76.0 Fatty (change of) liver, not elsewhere classified	0.004	0.996	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.000	0.996	0.004
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.000	0.996	0.004
T36.0 Penicillins	0.000	0.996	0.004
T41 Poisoning by anaesthetics and therapeutic gases	0.000	0.996	0.004
Chapter IX Diseases of the circulatory system	0.004	0.996	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.000	0.996	0.004
I71 Aortic aneurysm and dissection	0.004	0.996	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.000	0.996	0.004
F31.3 Bipolar affective disorder, current episode mild or moderate depression	0.004	0.996	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.000	0.996	0.004
F31.6 Bipolar affective disorder, current episode mixed	0.004	0.996	0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.004	0.996	0.000
T43.9 Psychotropic drug, unspecified	0.000	0.996	0.004
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.000	0.996	0.004
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.000	0.996	0.004
I27 Other pulmonary heart diseases	0.004	0.996	0.000
T36.3 Macrolides	0.000	0.996	0.004
T43.3 Phenothiazine antipsychotics and neuroleptics	0.000	0.996	0.004
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.000	0.996	0.004
O72.1 Other immediate postpartum haemorrhage	0.000	0.996	0.004
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms	0.004	0.996	0.000
F31.7 Bipolar affective disorder, currently in remission	0.004	0.996	0.000
I27.0 Primary pulmonary hypertension	0.004	0.996	0.000
I05 Rheumatic mitral valve diseases	0.004	0.996	0.000
T36.4 Tetracyclines	0.000	0.996	0.004
T43.8 Other psychotropic drugs, not elsewhere classified	0.000	0.996	0.004
T36.9 Systemic antibiotic, unspecified	0.000	0.996	0.004
T36.7 Antifungal antibiotics, systemically used	0.000	0.996	0.004
T36.6 Rifamycins	0.000	0.996	0.004
T36.5 Aminoglycosides	0.000	0.996	0.004
T36.2 Chloramphenicol group	0.000	0.996	0.004
K76 Other diseases of liver	0.004	0.996	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.000	0.996	0.004
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.004	0.996	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.004	0.996	0.000
T36.8 Other systemic antibiotics	0.000	0.996	0.004
I06 Rheumatic aortic valve diseases	0.004	0.996	0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.004	0.996	0.000
I27.2 Other secondary pulmonary hypertension	0.004	0.996	0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms	0.004	0.996	0.000
I08.9 Multiple valve disease, unspecified	0.004	0.996	0.000
I08.0 Disorders of both mitral and aortic valves	0.004	0.996	0.000
I09 Other rheumatic heart diseases	0.004	0.996	0.000
K70.3 Alcoholic cirrhosis of liver	0.004	0.996	0.000
F31.8 Other bipolar affective disorders	0.004	0.996	0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms	0.004	0.996	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.000	0.996	0.003
K70 Alcoholic liver disease	0.004	0.996	0.000
H04.2 Epiphora	0.004	0.996	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.996	0.003
T45.1 Antineoplastic and immunosuppressive drugs	0.000	0.996	0.003
T48.6 Antiasthmatics, not elsewhere classified	0.000	0.996	0.003
I08.8 Other multiple valve diseases	0.003	0.996	0.000
I71.3 Abdominal aortic aneurysm, ruptured	0.003	0.996	0.000
I71.0 Dissection of aorta [any part]	0.003	0.996	0.000
T43.6 Psychostimulants with abuse potential	0.000	0.996	0.003
T50.8 Diagnostic agents	0.000	0.996	0.003
T48.5 Anti-common-cold drugs	0.000	0.997	0.003
T45.0 Antiallergic and antiemetic drugs	0.000	0.997	0.003
T50.1 Loop [high-ceiling] diuretics	0.000	0.997	0.003
M11.2 Other chondrocalcinosis	0.000	0.997	0.003
I07 Rheumatic tricuspid valve diseases	0.003	0.997	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.000	0.997	0.003
T48.4 Expectorants	0.000	0.997	0.003
T48.3 Antitussives	0.000	0.997	0.003
T48.2 Other and unspecified agents primarily acting on muscles	0.000	0.997	0.003
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.000	0.997	0.003
T48.0 Oxytocic drugs	0.000	0.997	0.003
I70-I79 Diseases of arteries, arterioles and capillaries	0.003	0.997	0.000
I05.9 Mitral valve disease, unspecified	0.003	0.997	0.000
K76.9 Liver disease, unspecified	0.003	0.997	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.000	0.997	0.003
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms	0.003	0.997	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.003	0.997	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.003	0.997	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.000	0.997	0.003
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.000	0.997	0.003
T37.5 Antiviral drugs	0.000	0.997	0.003
T37.4 Anthelminthics	0.000	0.997	0.003
T37.3 Other antiprotozoal drugs	0.000	0.997	0.003
T37.1 Antimycobacterial drugs	0.000	0.997	0.003
T37.0 Sulphonamides	0.000	0.997	0.003
T40.5 Cocaine	0.000	0.997	0.003
I44.7 Left bundle-branch block, unspecified	0.003	0.997	0.000
I71.1 Thoracic aortic aneurysm, ruptured	0.003	0.997	0.000
T45.9 Primarily systemic and haematological agent, unspecified	0.000	0.997	0.003
T45.8 Other primarily systemic and haematological agents	0.000	0.997	0.003
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.000	0.997	0.003
T45.6 Fibrinolysis-affecting drugs	0.000	0.997	0.003
T45.3 Enzymes, not elsewhere classified	0.000	0.997	0.003
T37.8 Other specified systemic anti-infectives and antiparasitics	0.000	0.997	0.003
T50.7 Analeptics and opioid receptor antagonists	0.000	0.997	0.003
T50.5 Appetite depressants	0.000	0.997	0.003
T50.3 Electrolytic, caloric and water-balance agents	0.000	0.997	0.003
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.000	0.997	0.003
T50.0 Mineralocorticoids and their antagonists	0.000	0.997	0.003
K76.6 Portal hypertension	0.003	0.997	0.000
T41.5 Therapeutic gases	0.000	0.997	0.003
T41.4 Anaesthetic, unspecified	0.000	0.997	0.003
T41.3 Local anaesthetics	0.000	0.997	0.003
T41.1 Intravenous anaesthetics	0.000	0.997	0.003
T41.0 Inhaled anaesthetics	0.000	0.997	0.003
T43.5 Other and unspecified antipsychotics and neuroleptics	0.000	0.997	0.003
T50.4 Drugs affecting uric acid metabolism	0.000	0.997	0.003
T49.9 Topical agent, unspecified	0.000	0.997	0.003
T49.8 Other topical agents	0.000	0.997	0.003
T49.7 Dental drugs, topically applied	0.000	0.997	0.003
T49.6 Otorhinolaryngological drugs and preparations	0.000	0.997	0.003
T49.5 Ophthalmological drugs and preparations	0.000	0.997	0.003
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.000	0.997	0.003
T49.3 Emollients, demulcents and protectants	0.000	0.997	0.003
T49.2 Local astringents and local detergents	0.000	0.997	0.003
T49.1 Antipruritics	0.000	0.997	0.003
I00-I02 Acute rheumatic fever	0.003	0.997	0.000
T45.4 Iron and its compounds	0.000	0.997	0.003
I71.8 Aortic aneurysm of unspecified site, ruptured	0.003	0.997	0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.003	0.997	0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.003	0.997	0.000
T40.1 Heroin	0.000	0.997	0.003
T41.2 Other and unspecified general anaesthetics	0.000	0.997	0.003
T47.2 Stimulant laxatives	0.000	0.997	0.003
T47.0 Histamine H(2)-receptor antagonists	0.000	0.997	0.003
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.997	0.003
M54.99 Dorsalgia, unspecified (Site unspecified)	0.003	0.997	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.000	0.997	0.003
T42.4 Benzodiazepines	0.000	0.997	0.003
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.000	0.997	0.003
T47.8 Other agents primarily affecting the gastro-intestinal system	0.000	0.997	0.003
T47.7 Emetics	0.000	0.997	0.003
T47.5 Digestants	0.000	0.997	0.003
T47.3 Saline and osmotic laxatives	0.000	0.997	0.003
K70.1 Alcoholic hepatitis	0.003	0.997	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.000	0.997	0.003
T50.6 Antidotes and chelating agents, not elsewhere classified	0.000	0.997	0.003
I27.9 Pulmonary heart disease, unspecified	0.003	0.997	0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.000	0.997	0.003
I27.1 Kyphoscoliotic heart disease	0.003	0.997	0.000
T47.6 Antidiarrhoeal drugs	0.000	0.997	0.003
I27.8 Other specified pulmonary heart diseases	0.003	0.997	0.000
T45.2 Vitamins, not elsewhere classified	0.000	0.997	0.003
T47.1 Other antacids and anti-gastric-secretion drugs	0.000	0.997	0.003
I05.2 Mitral stenosis with insufficiency	0.003	0.997	0.000
T47.4 Other laxatives	0.000	0.997	0.003
I05.8 Other mitral valve diseases	0.003	0.997	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.000	0.997	0.003
T40.8 Lysergide [LSD]	0.000	0.997	0.003
T40.7 Cannabis (derivatives)	0.000	0.997	0.003
T40.0 Opium	0.000	0.997	0.003
K70-K77 Diseases of liver	0.003	0.997	0.000
T40.3 Methadone	0.000	0.997	0.003
T45.5 Anticoagulants	0.000	0.997	0.003
I28 Other diseases of pulmonary vessels	0.003	0.997	0.000
I06.1 Rheumatic aortic insufficiency	0.003	0.997	0.000
I09.9 Rheumatic heart disease, unspecified	0.003	0.997	0.000
K70.4 Alcoholic hepatic failure	0.003	0.997	0.000
K70.2 Alcoholic fibrosis and sclerosis of liver	0.003	0.997	0.000
I06.9 Rheumatic aortic valve disease, unspecified	0.003	0.997	0.000
I06.2 Rheumatic aortic stenosis with insufficiency	0.003	0.997	0.000
I05.1 Rheumatic mitral insufficiency	0.003	0.997	0.000
I06.0 Rheumatic aortic stenosis	0.003	0.997	0.000
K76.5 Hepatic veno-occlusive disease	0.003	0.997	0.000
K76.4 Peliosis hepatis	0.003	0.997	0.000
K76.2 Central haemorrhagic necrosis of liver	0.003	0.997	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.000	0.997	0.003
T42.5 Mixed antiepileptics, not elsewhere classified	0.000	0.997	0.003
T42.2 Succinimides and oxazolidinediones	0.000	0.997	0.003
K60 Fissure and fistula of anal and rectal regions	0.000	0.997	0.003
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.997	0.003
I06.8 Other rheumatic aortic valve diseases	0.003	0.997	0.000
T42.1 Iminostilbenes	0.000	0.997	0.003
I05.0 Mitral stenosis	0.003	0.997	0.000
T40.4 Other synthetic narcotics	0.000	0.997	0.003
I09.8 Other specified rheumatic heart diseases	0.003	0.997	0.000
I09.2 Chronic rheumatic pericarditis	0.003	0.997	0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified	0.003	0.997	0.000
I09.0 Rheumatic myocarditis	0.003	0.997	0.000
K76.3 Infarction of liver	0.003	0.997	0.000
T42.3 Barbiturates	0.000	0.997	0.003
T50.9 Other and unspecified drugs, medicaments and biological substances	0.000	0.997	0.003
K70.0 Alcoholic fatty liver	0.003	0.997	0.000
K76.7 Hepatorenal syndrome	0.003	0.997	0.000
K60.1 Chronic anal fissure	0.000	0.997	0.003
K76.1 Chronic passive congestion of liver	0.003	0.997	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.000	0.997	0.003
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.000	0.997	0.003
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.000	0.997	0.003
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.000	0.997	0.003
T44.1 Other parasympathomimetics [cholinergics]	0.000	0.997	0.003
T44.0 Anticholinesterase agents	0.000	0.997	0.003
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.003	0.997	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.000	0.997	0.003
T38.9 Other and unspecified hormone antagonists	0.000	0.997	0.003
T38.7 Androgens and anabolic congeners	0.000	0.997	0.003
T38.4 Oral contraceptives	0.000	0.997	0.003
T38.2 Antithyroid drugs	0.000	0.997	0.003
K70.9 Alcoholic liver disease, unspecified	0.003	0.997	0.000
T38.5 Other oestrogens and progestogens	0.000	0.997	0.003
T40.2 Other opioids	0.000	0.997	0.003
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.997	0.003
M11.27 Other chondrocalcinosis (Ankle and foot)	0.000	0.997	0.003
M11.21 Other chondrocalcinosis (Shoulder region)	0.000	0.997	0.003
T38.0 Glucocorticoids and synthetic analogues	0.000	0.997	0.002
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.000	0.997	0.003
I70 Atherosclerosis	0.003	0.997	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.997	0.002
T40.6 Other and unspecified narcotics	0.000	0.997	0.003
T42.0 Hydantoin derivatives	0.000	0.997	0.003
K75 Other inflammatory liver diseases	0.003	0.997	0.000
I07.9 Tricuspid valve disease, unspecified	0.003	0.997	0.000
I07.8 Other tricuspid valve diseases	0.003	0.997	0.000
I07.2 Tricuspid stenosis with insufficiency	0.003	0.997	0.000
I07.0 Tricuspid stenosis	0.003	0.997	0.000
M11.29 Other chondrocalcinosis (Site unspecified)	0.000	0.997	0.003
M11.28 Other chondrocalcinosis (Other)	0.000	0.997	0.003
M11.25 Other chondrocalcinosis (Pelvic region and thigh)	0.000	0.997	0.003
M11.24 Other chondrocalcinosis (Hand)	0.000	0.997	0.003
M11.22 Other chondrocalcinosis (Upper arm)	0.000	0.997	0.003
M11.20 Other chondrocalcinosis (Multiple sites)	0.000	0.997	0.003
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.000	0.997	0.002
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.997	0.002
T46.5 Other antihypertensive drugs, not elsewhere classified	0.000	0.997	0.002
M11.23 Other chondrocalcinosis (Forearm)	0.000	0.997	0.003
T38.1 Thyroid hormones and substitutes	0.000	0.997	0.002
T46.8 Antivaricose drugs, including sclerosing agents	0.000	0.997	0.002
T46.7 Peripheral vasodilators	0.000	0.997	0.002
I74 Arterial embolism and thrombosis	0.003	0.997	0.000
K76.8 Other specified diseases of liver	0.003	0.997	0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.000	0.997	0.002
N19 Unspecified renal failure	0.000	0.997	0.003
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.000	0.997	0.002
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.000	0.997	0.002
I07.1 Tricuspid insufficiency	0.002	0.997	0.000
K60.5 Anorectal fistula	0.000	0.997	0.003
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.000	0.997	0.002
I02 Rheumatic chorea	0.002	0.997	0.000
I01 Rheumatic fever with heart involvement	0.002	0.997	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations