TreeWAS – Variant ID: rs147721431

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Showing all nodes without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability
M25.5 Pain in joint	0.153	0.847
M25 Other joint disorders, not elsewhere classified	0.152	0.848
M20 Acquired deformities of fingers and toes	0.151	0.849
M20-M25 Other joint disorders	0.151	0.849
M25.55 Pain in joint (Pelvic region and thigh)	0.150	0.850
M25.51 Pain in joint (Shoulder region)	0.141	0.859
M20.1 Hallux valgus (acquired)	0.137	0.863
M20.5 Other deformities of toe(s) (acquired)	0.130	0.870
M20.0 Deformity of finger(s)	0.129	0.871
M25.0 Haemarthrosis	0.127	0.873
M21 Other acquired deformities of limbs	0.123	0.877
M51 Other intervertebral disk disorders	0.123	0.877
M50-M54 Other dorsopathies	0.121	0.879
M25.56 Pain in joint (Lower leg)	0.121	0.879
M25.50 Pain in joint (Multiple sites)	0.120	0.880
M51.2 Other specified intervertebral disk displacement	0.120	0.880
M31 Other necrotising vasculopathies	0.119	0.881
M20.2 Hallux rigidus	0.117	0.883
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.117	0.883
M20.3 Other deformity of hallux (acquired)	0.117	0.883
M25.8 Other specified joint disorders	0.115	0.885
M20.4 Other hammer toe(s) (acquired)	0.113	0.887
M20.6 Acquired deformity of toe(s), unspecified	0.112	0.888
M25.59 Pain in joint (Site unspecified)	0.110	0.890
M25.58 Pain in joint (Other)	0.110	0.890
M25.52 Pain in joint (Upper arm)	0.110	0.890
M25.06 Haemarthrosis (Lower leg)	0.110	0.890
M25.9 Joint disorder, unspecified	0.109	0.891
M25.6 Stiffness of joint, not elsewhere classified	0.109	0.891
M25.3 Other instability of joint	0.109	0.891
M25.2 Flail joint	0.109	0.891
M25.1 Fistula of joint	0.109	0.891
M25.7 Osteophyte	0.109	0.891
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.108	0.892
M34 Systemic sclerosis	0.108	0.892
M33 Dermatopolymyositis	0.108	0.892
M32 Systemic lupus erythematosus	0.108	0.892
M30 Polyarteritis nodosa and related conditions	0.108	0.892
M35 Other systemic involvement of connective tissue	0.108	0.892
M25.53 Pain in joint (Forearm)	0.106	0.894
M51.8 Other specified intervertebral disk disorders	0.104	0.896
M54 Dorsalgia	0.102	0.898
M22 Disorders of patella	0.100	0.900
M24 Other specific joint derangements	0.099	0.901
M25.54 Pain in joint (Hand)	0.099	0.901
M51.0 Lumbar and other intervertebral disk disorders with myelopathy	0.098	0.902
M25.57 Pain in joint (Ankle and foot)	0.098	0.902
M21.1 Varus deformity, not elsewhere classified	0.098	0.902
M86-M90 Other osteopathies	0.098	0.902
M21.3 Wrist or foot drop (acquired)	0.095	0.905
M25.4 Effusion of joint	0.094	0.905
M31.6 Other giant cell arteritis	0.094	0.905
M50 Cervical disk disorders	0.094	0.906
M51.9 Intervertebral disk disorder, unspecified	0.093	0.907
M25.09 Haemarthrosis (Site unspecified)	0.091	0.908
M25.08 Haemarthrosis (Other)	0.091	0.908
M25.07 Haemarthrosis (Ankle and foot)	0.091	0.908
M25.05 Haemarthrosis (Pelvic region and thigh)	0.091	0.908
M25.04 Haemarthrosis (Hand)	0.091	0.908
M25.03 Haemarthrosis (Forearm)	0.091	0.908
M25.02 Haemarthrosis (Upper arm)	0.091	0.908
M25.01 Haemarthrosis (Shoulder region)	0.091	0.908
M25.00 Haemarthrosis (Multiple sites)	0.091	0.908
M21.0 Valgus deformity, not elsewhere classified	0.091	0.909
M21.9 Acquired deformity of limb, unspecified	0.089	0.911
M21.8 Other specified acquired deformities of limbs	0.089	0.911
M21.7 Unequal limb length (acquired)	0.089	0.911
M21.6 Other acquired deformities of ankle and foot	0.089	0.911
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.089	0.911
M21.4 Flat foot [pes planus] (acquired)	0.089	0.911
M21.2 Flexion deformity	0.089	0.911
M25.87 Other specified joint disorders (Ankle and foot)	0.088	0.912
M51.3 Other specified intervertebral disk degeneration	0.088	0.912
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.088	0.912
M51.4 Schmorl's nodes	0.088	0.912
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.088	0.912
M31.3 Wegener's granulomatosis	0.088	0.912
M25.77 Osteophyte (Ankle and foot)	0.087	0.913
M35.7 Hypermobility syndrome	0.087	0.913
M53 Other dorsopathies, not elsewhere classified	0.087	0.913
M54.5 Low back pain	0.087	0.913
M40-M43 Deforming dorsopathies	0.086	0.914
M31.9 Necrotising vasculopathy, unspecified	0.085	0.915
M31.8 Other specified necrotising vasculopathies	0.085	0.915
M31.7 Microscopic polyangiitis	0.085	0.915
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.085	0.915
M31.4 Aortic arch syndrome [Takayasu]	0.085	0.915
M31.2 Lethal midline granuloma	0.085	0.915
M31.1 Thrombotic microangiopathy	0.085	0.915
M31.0 Hypersensitivity angiitis	0.085	0.915
M91-M94 Chondropathies	0.084	0.916
M60-M63 Disorders of muscles	0.084	0.916
M00-M03 Infectious arthropathies	0.084	0.916
M25.89 Other specified joint disorders (Site unspecified)	0.082	0.917
M25.88 Other specified joint disorders (Other)	0.082	0.917
M25.86 Other specified joint disorders (Lower leg)	0.082	0.917
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.082	0.917
M25.84 Other specified joint disorders (Hand)	0.082	0.917
M25.83 Other specified joint disorders (Forearm)	0.082	0.917
M25.82 Other specified joint disorders (Upper arm)	0.082	0.917
M25.81 Other specified joint disorders (Shoulder region)	0.082	0.917
M25.80 Other specified joint disorders (Multiple sites)	0.082	0.917
M25.74 Osteophyte (Hand)	0.082	0.918
M54.6 Pain in thoracic spine	0.082	0.918
M87 Osteonecrosis	0.081	0.919
M25.75 Osteophyte (Pelvic region and thigh)	0.080	0.920
M54.59 Low back pain (Site unspecified)	0.080	0.920
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.080	0.920
M25.19 Fistula of joint (Site unspecified)	0.078	0.921
M25.18 Fistula of joint (Other)	0.078	0.921
M25.17 Fistula of joint (Ankle and foot)	0.078	0.921
M25.16 Fistula of joint (Lower leg)	0.078	0.921
M25.15 Fistula of joint (Pelvic region and thigh)	0.078	0.921
M25.14 Fistula of joint (Hand)	0.078	0.921
M25.13 Fistula of joint (Forearm)	0.078	0.921
M25.12 Fistula of joint (Upper arm)	0.078	0.921
M25.11 Fistula of joint (Shoulder region)	0.078	0.921
M25.10 Fistula of joint (Multiple sites)	0.078	0.921
M25.29 Flail joint (Site unspecified)	0.078	0.921
M25.28 Flail joint (Other)	0.078	0.921
M25.27 Flail joint (Ankle and foot)	0.078	0.921
M25.26 Flail joint (Lower leg)	0.078	0.921
M25.25 Flail joint (Pelvic region and thigh)	0.078	0.921
M25.24 Flail joint (Hand)	0.078	0.921
M25.23 Flail joint (Forearm)	0.078	0.921
M25.22 Flail joint (Upper arm)	0.078	0.921
M25.21 Flail joint (Shoulder region)	0.078	0.921
M25.20 Flail joint (Multiple sites)	0.078	0.921
M25.39 Other instability of joint (Site unspecified)	0.078	0.921
M25.38 Other instability of joint (Other)	0.078	0.921
M25.37 Other instability of joint (Ankle and foot)	0.078	0.921
M25.36 Other instability of joint (Lower leg)	0.078	0.921
M25.35 Other instability of joint (Pelvic region and thigh)	0.078	0.921
M25.34 Other instability of joint (Hand)	0.078	0.921
M25.33 Other instability of joint (Forearm)	0.078	0.921
M25.32 Other instability of joint (Upper arm)	0.078	0.921
M25.31 Other instability of joint (Shoulder region)	0.078	0.921
M25.30 Other instability of joint (Multiple sites)	0.078	0.921
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.078	0.921
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.078	0.921
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.078	0.921
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.078	0.921
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.078	0.921
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.078	0.921
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.078	0.921
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.078	0.921
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.078	0.921
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.078	0.921
M25.99 Joint disorder, unspecified (Site unspecified)	0.078	0.921
M25.98 Joint disorder, unspecified (Other)	0.078	0.921
M25.97 Joint disorder, unspecified (Ankle and foot)	0.078	0.921
M25.96 Joint disorder, unspecified (Lower leg)	0.078	0.921
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.078	0.921
M25.94 Joint disorder, unspecified (Hand)	0.078	0.921
M25.93 Joint disorder, unspecified (Forearm)	0.078	0.921
M25.92 Joint disorder, unspecified (Upper arm)	0.078	0.921
M25.91 Joint disorder, unspecified (Shoulder region)	0.078	0.921
M25.90 Joint disorder, unspecified (Multiple sites)	0.078	0.921
M25.79 Osteophyte (Site unspecified)	0.078	0.922
M25.73 Osteophyte (Forearm)	0.078	0.922
M25.72 Osteophyte (Upper arm)	0.078	0.922
M25.71 Osteophyte (Shoulder region)	0.078	0.922
M25.70 Osteophyte (Multiple sites)	0.078	0.922
M54.1 Radiculopathy	0.078	0.922
M30.8 Other conditions related to polyarteritis nodosa	0.078	0.922
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.078	0.922
M30.2 Juvenile polyarteritis	0.078	0.922
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.078	0.922
M30.0 Polyarteritis nodosa	0.078	0.922
M32.9 Systemic lupus erythematosus, unspecified	0.078	0.922
M32.8 Other forms of systemic lupus erythematosus	0.078	0.922
M32.1 Systemic lupus erythematosus with organ or system involvement	0.078	0.922
M32.0 Drug-induced systemic lupus erythematosus	0.078	0.922
M33.9 Dermatopolymyositis, unspecified	0.078	0.922
M33.2 Polymyositis	0.078	0.922
M33.1 Other dermatomyositis	0.078	0.922
M33.0 Juvenile dermatomyositis	0.078	0.922
M34.9 Systemic sclerosis, unspecified	0.078	0.922
M34.8 Other forms of systemic sclerosis	0.078	0.922
M34.2 Systemic sclerosis induced by drugs and chemicals	0.078	0.922
M34.1 CR(E)ST syndrome	0.078	0.922
M34.0 Progressive systemic sclerosis	0.078	0.922
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.078	0.922
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.078	0.922
M36.3 Arthropathy in other blood disorders	0.078	0.922
M36.2 Haemophilic arthropathy	0.078	0.922
M36.1 Arthropathy in neoplastic disease	0.078	0.922
M36.0 Dermato(poly)myositis in neoplastic disease	0.078	0.922
M35.9 Systemic involvement of connective tissue, unspecified	0.077	0.923
M35.8 Other specified systemic involvement of connective tissue	0.077	0.923
M35.6 Relapsing panniculitis [Weber-Christian]	0.077	0.923
M35.5 Multifocal fibrosclerosis	0.077	0.923
M35.4 Diffuse (eosinophilic) fasciitis	0.077	0.923
M35.2 Behcet's disease	0.077	0.923
M35.1 Other overlap syndromes	0.077	0.923
M54.3 Sciatica	0.077	0.923
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.075	0.925
M90 Osteopathies in diseases classified elsewhere	0.074	0.926
M50.1 Cervical disk disorder with radiculopathy	0.074	0.926
M54.2 Cervicalgia	0.073	0.927
M54.8 Other dorsalgia	0.073	0.927
M54.0 Panniculitis affecting regions of neck and back	0.073	0.927
M35.3 Polymyalgia rheumatica	0.073	0.927
M23 Internal derangement of knee	0.073	0.927
M65-M68 Disorders of synovium and tendon	0.072	0.927
M50.3 Other cervical disk degeneration	0.072	0.928
M89 Other disorders of bone	0.072	0.928
M22.1 Recurrent subluxation of patella	0.072	0.928
M22.9 Disorder of patella, unspecified	0.072	0.928
M22.3 Other derangements of patella	0.072	0.928
M22.2 Patellofemoral disorders	0.072	0.928
M22.0 Recurrent dislocation of patella	0.072	0.928
M24.9 Joint derangement, unspecified	0.071	0.929
M24.8 Other specific joint derangements, not elsewhere classified	0.071	0.929
M24.7 Protrusio acetabuli	0.071	0.929
M24.6 Ankylosis of joint	0.071	0.929
M24.5 Contracture of joint	0.071	0.929
M24.4 Recurrent dislocation and subluxation of joint	0.071	0.929
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.071	0.929
M24.2 Disorder of ligament	0.071	0.929
M24.0 Loose body in joint	0.071	0.929
M54.4 Lumbago with sciatica	0.071	0.929
M88 Paget's disease of bone [osteitis deformans]	0.070	0.929
M86 Osteomyelitis	0.070	0.929
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.070	0.929
M21.18 Varus deformity, not elsewhere classified (Other)	0.070	0.929
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.070	0.929
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.070	0.929
M21.14 Varus deformity, not elsewhere classified (Hand)	0.070	0.929
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.070	0.929
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.070	0.929
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.070	0.929
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.070	0.929
M22.8 Other disorders of patella	0.070	0.930
M50.0 Cervical disk disorder with myelopathy	0.069	0.930
M25.78 Osteophyte (Other)	0.069	0.931
M21.39 Wrist or foot drop (acquired)-Site unspec	0.068	0.931
M21.38 Wrist or foot drop (acquired)-Other	0.068	0.931
M21.36 Wrist or foot drop (acquired)-Lower leg	0.068	0.931
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.068	0.931
M21.34 Wrist or foot drop (acquired) (Hand)	0.068	0.931
M21.33 Wrist or foot drop (acquired) (Forearm)	0.068	0.931
M21.32 Wrist or foot drop (acquired)-Upper arm	0.068	0.931
M21.31 Wrist or foot drop (acquired)-Shldr region	0.068	0.931
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.068	0.931
M35.0 Sicca syndrome [Sjogren]	0.068	0.932
M25.49 Effusion of joint (Site unspecified)	0.068	0.932
M25.48 Effusion of joint (Other)	0.068	0.932
M25.45 Effusion of joint (Pelvic region and thigh)	0.068	0.932
M25.44 Effusion of joint (Hand)	0.068	0.932
M25.43 Effusion of joint (Forearm)	0.068	0.932
M25.42 Effusion of joint (Upper arm)	0.068	0.932
M25.41 Effusion of joint (Shoulder region)	0.068	0.932
M25.40 Effusion of joint (Multiple sites)	0.068	0.932
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.068	0.932
M25.76 Osteophyte (Lower leg)	0.068	0.932
M50.9 Cervical disk disorder, unspecified	0.068	0.932
M50.8 Other cervical disk disorders	0.068	0.932
M70-M79 Other soft tissue disorders	0.067	0.932
M43 Other deforming dorsopathies	0.067	0.932
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.067	0.933
M54.64 Pain in thoracic spine (Thoracic region)	0.067	0.933
M25.47 Effusion of joint (Ankle and foot)	0.067	0.933
M80-M85 Disorders of bone density and structure	0.066	0.934
C44 Other malignant neoplasms of skin	0.066	0.934
M54.57 Low back pain (Lumbosacral region)	0.065	0.934
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.065	0.935
M21.08 Valgus deformity, not elsewhere classified (Other)	0.065	0.935
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.065	0.935
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.065	0.935
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.065	0.935
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.065	0.935
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.065	0.935
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.065	0.935
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.065	0.935
M22.4 Chondromalacia patellae	0.065	0.935
M05-M14 Inflammatory polyarthropathies	0.065	0.935
M87.2 Osteonecrosis due to previous trauma	0.065	0.935
C44.4 Skin of scalp and neck	0.065	0.935
M54.36 Sciatica (Lumbar region)	0.065	0.935
M87.9 Osteonecrosis, unspecified	0.064	0.936
M21.29 Flexion deformity (Site unspecified)	0.064	0.936
M21.28 Flexion deformity (Other)	0.064	0.936
M21.27 Flexion deformity (Ankle and foot)	0.064	0.936
M21.26 Flexion deformity (Lower leg)	0.064	0.936
M21.25 Flexion deformity (Pelvic region and thigh)	0.064	0.936
M21.24 Flexion deformity (Hand)	0.064	0.936
M21.23 Flexion deformity (Forearm)	0.064	0.936
M21.22 Flexion deformity (Upper arm)	0.064	0.936
M21.21 Flexion deformity (Shoulder region)	0.064	0.936
M21.20 Flexion deformity (Multiple sites)	0.064	0.936
M21.49 Flat foot [pes planus] (acquired)-Site unspec	0.064	0.936
M21.48 Flat foot [pes planus] (acquired)-Other	0.064	0.936
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.064	0.936
M21.46 Flat foot [pes planus] (acquired)-Lower leg	0.064	0.936
M21.45 Flat foot [pes planus] (acquired)-Pelvic/thigh	0.064	0.936
M21.44 Flat foot [pes planus] (acquired)-Hand	0.064	0.936
M21.43 Flat foot [pes planus] (acquired)-Forearm	0.064	0.936
M21.42 Flat foot [pes planus] (acquired)-Upper arm	0.064	0.936
M21.41 Flat foot [pes planus] (acquired)-Shldr region	0.064	0.936
M21.40 Flat foot [pes planus] (acquired)-Mult sites	0.064	0.936
M21.59 Acquired clawhand, clubhand, clawfoot and clubfoot-Site uns	0.064	0.936
M21.58 Acquired clawhand, clubhand, clawfoot and clubfoot-Other	0.064	0.936
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.064	0.936
M21.56 Acquired clawhand, clubhand, clawfoot and clubfoot-Lower le	0.064	0.936
M21.55 Acquired clawhand, clubhand, clawfoot and clubfoot-Pelvic/t	0.064	0.936
M21.54 Acquired clawhand, clubhand, clawfoot and clubfoot (Hand)	0.064	0.936
M21.53 Acquired clawhand, clubhand, clawfoot and clubfoot-Forearm	0.064	0.936
M21.52 Acquired clawhand, clubhand, clawfoot and clubfoot-Upper ar	0.064	0.936
M21.51 Acquired clawhand, clubhand, clawfoot and clubfoot-Shldr re	0.064	0.936
M21.50 Acquired clawhand, clubhand, clawfoot and clubfoot (Multiple sites)	0.064	0.936
M21.69 Other acquired deformities of ankle and foot-Site unspec	0.064	0.936
M21.68 Other acquired deformities of ankle and foot-Other	0.064	0.936
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.064	0.936
M21.66 Other acquired deformities of ankle and foot-Lower leg	0.064	0.936
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh	0.064	0.936
M21.64 Other acquired deformities of ankle and foot-Hand	0.064	0.936
M21.63 Other acquired deformities of ankle and foot-Forearm	0.064	0.936
M21.62 Other acquired deformities of ankle and foot-Upper arm	0.064	0.936
M21.61 Other acquired deformities of ankle and foot-Shldr region	0.064	0.936
M21.60 Other acquired deformities of ankle and foot-Mult sites	0.064	0.936
M21.79 Unequal limb length (acquired) (Site unspecified)	0.064	0.936
M21.78 Unequal limb length (acquired)-Other	0.064	0.936
M21.77 Unequal limb length (acquired) (Ankle and foot)	0.064	0.936
M21.76 Unequal limb length (acquired) (Lower leg)	0.064	0.936
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.064	0.936
M21.74 Unequal limb length (acquired) (Hand)	0.064	0.936
M21.73 Unequal limb length (acquired) (Forearm)	0.064	0.936
M21.72 Unequal limb length (acquired) (Upper arm)	0.064	0.936
M21.71 Unequal limb length (acquired)-Shldr region	0.064	0.936
M21.70 Unequal limb length (acquired) (Multiple sites)	0.064	0.936
M21.89 Other specified acquired deformities of limbs (Site unspecified)	0.064	0.936
M21.88 Other specified acquired deformities of limbs-Other	0.064	0.936
M21.87 Other specified acquired deformities of limbs (Ankle and foot)	0.064	0.936
M21.86 Other specified acquired deformities of limbs (Lower leg)	0.064	0.936
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)	0.064	0.936
M21.84 Other specified acquired deformities of limbs (Hand)	0.064	0.936
M21.83 Other specified acquired deformities of limbs (Forearm)	0.064	0.936
M21.82 Other specified acquired deformities of limbs (Upper arm)	0.064	0.936
M21.81 Other specified acquired deformities of limbs (Shoulder region)	0.064	0.936
M21.80 Other specified acquired deformities of limbs (Multiple sites)	0.064	0.936
M21.99 Acquired deformity of limb, unspecified (Site unspecified)	0.064	0.936
M21.98 Acquired deformity of limb, unspecified-Other	0.064	0.936
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.064	0.936
M21.96 Acquired deformity of limb, unspecified (Lower leg)	0.064	0.936
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)	0.064	0.936
M21.94 Acquired deformity of limb, unspecified (Hand)	0.064	0.936
M21.93 Acquired deformity of limb, unspecified (Forearm)	0.064	0.936
M21.92 Acquired deformity of limb, unspecified (Upper arm)	0.064	0.936
M21.91 Acquired deformity of limb, unspecified (Shoulder region)	0.064	0.936
M21.90 Acquired deformity of limb, unspecified (Multiple sites)	0.064	0.936
M51.19 Lumbar and other intervertebral disc disorders with radiculopathy; site unspecified	0.063	0.936
M51.16 Intervertebral disc disorders w radiculopathy, lumbar region	0.063	0.936
M51.37 Other intervertebral disc degeneration, lumbosacral region	0.063	0.936
M99 Biomechanical lesions, not elsewhere classified	0.063	0.937
M53.9 Dorsopathy, unspecified	0.063	0.937
M53.8 Other specified dorsopathies	0.063	0.937
M53.2 Spinal instabilities	0.063	0.937
M53.1 Cervicobrachial syndrome	0.063	0.937
M53.0 Cervicocranial syndrome	0.063	0.937
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.062	0.937
M24.1 Other articular cartilage disorders	0.062	0.937
C43-C44 Melanoma and other malignant neoplasms of skin	0.063	0.937
D37-D48 Neoplasms of uncertain or unknown behaviour	0.062	0.938
M54.55 Low back pain (Thoracolumbar region)	0.062	0.938
M54.54 Low back pain-Thoracic	0.062	0.938
M54.53 Low back pain-Cervicothoracic	0.062	0.938
M54.52 Low back pain-Cervical	0.062	0.938
M54.51 Low back pain-Occipit-atl-axl	0.062	0.938
M54.50 Low back pain (Multiple sites in spine)	0.062	0.938
M42 Spinal osteochondrosis	0.062	0.938
M40 Kyphosis and lordosis	0.062	0.938
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.062	0.938
Chapter II Neoplasms	0.062	0.938
C44.6 Skin of upper limb, including shoulder	0.061	0.939
M50.2 Other cervical disk displacement	0.061	0.939
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.061	0.939
M02 Reactive arthropathies	0.061	0.939
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.061	0.939
M00 Pyogenic arthritis	0.061	0.939
M63 Disorders of muscle in diseases classified elsewhere	0.061	0.939
M62 Other disorders of muscle	0.061	0.939
M61 Calcification and ossification of muscle	0.061	0.939
M60 Myositis	0.061	0.939
M94 Other disorders of cartilage	0.061	0.939
M93 Other osteochondropathies	0.061	0.939
M92 Other juvenile osteochondrosis	0.061	0.939
M91 Juvenile osteochondrosis of hip and pelvis	0.061	0.939
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.060	0.940
M54.16 Radiculopathy (Lumbar region)	0.060	0.940
Chapter VI Diseases of the nervous system	0.060	0.940
M54.69 Pain in thoracic spine-Site unspe	0.059	0.941
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.059	0.941
M54.67 Pain in thoracic spine-Lumbosacral	0.059	0.941
M54.66 Pain in thoracic spine-Lumbar	0.059	0.941
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.059	0.941
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.059	0.941
M54.62 Pain in thoracic spine-Cervical	0.059	0.941
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.059	0.941
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.059	0.941
C44.3 Skin of other and unspecified parts of face	0.059	0.941
M87.8 Other osteonecrosis	0.058	0.942
M87.3 Other secondary osteonecrosis	0.058	0.942
M87.1 Osteonecrosis due to drugs	0.058	0.942
M87.0 Idiopathic aseptic necrosis of bone	0.058	0.942
M75 Shoulder lesions	0.058	0.942
M41 Scoliosis	0.057	0.942
M54.12 Radiculopathy (Cervical region)	0.057	0.943
# Top node	0.057	0.943
M90.7 Fracture of bone in neoplastic disease	0.057	0.943
M45-M49 Spondylopathies	0.057	0.943
M89.8 Other specified disorders of bone	0.056	0.944
M66 Spontaneous rupture of synovium and tendon	0.056	0.944
M54.19 Radiculopathy (Site unspecified)	0.056	0.944
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.056	0.944
M54.17 Radiculopathy (Lumbosacral region)	0.056	0.944
M54.15 Radiculopathy (Thoracolumbar region)	0.056	0.944
M54.14 Radiculopathy (Thoracic region)	0.056	0.944
M54.13 Radiculopathy (Cervicothoracic region)	0.056	0.944
M54.11 Radiculopathy (Occipito-atlanto-axial region)	0.056	0.944
M54.10 Radiculopathy (Multiple sites in spine)	0.056	0.944
M32.90 Systemic lupus erythematosus, unspecified, Multiple sites	0.056	0.944
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified	0.056	0.944
G90-G99 Other disorders of the nervous system	0.056	0.944
M23.5 Chronic instability of knee	0.055	0.945
M54.38 Sciatica (Sacral and sacrococcygeal region)	0.055	0.945
M54.37 Sciatica (Lumbosacral region)	0.055	0.945
M54.35 Sciatica (Thoracolumbar region)	0.055	0.945
M54.34 Sciatica-Thoracic	0.055	0.945
M54.33 Sciatica-Cervicothoracic	0.055	0.945
M54.32 Sciatica-Cervical	0.055	0.945
M54.31 Sciatica-Occipit-atl-axl	0.055	0.945
M54.30 Sciatica (Multiple sites in spine)	0.055	0.945
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.055	0.945
D45 Polycythaemia vera	0.055	0.945
G40 Epilepsy	0.055	0.945
M25.46 Effusion of joint (Lower leg)	0.054	0.945
G40-G47 Episodic and paroxysmal disorders	0.054	0.945
M43.1 Spondylolisthesis	0.054	0.946
M54.9 Dorsalgia, unspecified	0.054	0.946
M96.8 Other postprocedural musculoskeletal disorders	0.053	0.946
G40.9 Epilepsy, unspecified	0.054	0.946
G50-G59 Nerve, nerve root and plexus disorders	0.053	0.947
M90.8 Osteopathy in other diseases classified elsewhere	0.053	0.947
M90.6 Osteitis deformans in neoplastic disease	0.053	0.947
M90.5 Osteonecrosis in other diseases classified elsewhere	0.053	0.947
M90.4 Osteonecrosis due to heamoglobinopathy	0.053	0.947
M90.3 Osteonecrosis in caisson disease	0.053	0.947
M90.2 Osteopathy in other infectious diseases classified elsewhere	0.053	0.947
M90.1 Periostitis in other infectious diseases classified elsewhere	0.053	0.947
M90.0 Tuberculosis of bone	0.053	0.947
M87.20 Osteonecrosis due to previous trauma (Multiple sites)	0.053	0.947
M54.22 Cervicalgia (Cervical region)	0.053	0.947
M54.29 Cervicalgia-Site unspe	0.053	0.947
M54.28 Cervicalgia-Sacral/sacrococ	0.053	0.947
M54.27 Cervicalgia-Lumbosacral	0.053	0.947
M54.26 Cervicalgia-Lumbar	0.053	0.947
M54.25 Cervicalgia-Thoracolumbar	0.053	0.947
M54.24 Cervicalgia-Thoracic	0.053	0.947
M54.23 Cervicalgia (Cervicothoracic region)	0.053	0.947
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.053	0.947
M54.20 Cervicalgia-Mult site	0.053	0.947
D41 Neoplasm of uncertain or unknown behaviour of urinary organs	0.053	0.947
M54.09 Panniculitis affecting regions of neck and back (Site unspecified)	0.053	0.947
M54.08 Panniculitis affecting regions of neck and back (Sacral and sacrococcygeal region)	0.053	0.947
M54.07 Panniculitis affecting regions of neck and back (Lumbosacral region)	0.053	0.947
M54.06 Panniculitis affecting regions of neck and back (Lumbar region)	0.053	0.947
M54.05 Panniculitis affecting regions of neck and back (Thoracolumbar region)	0.053	0.947
M54.04 Panniculitis affecting regions of neck and back (Thoracic region)	0.053	0.947
M54.03 Panniculitis affecting regions of neck and back (Cervicothoracic region)	0.053	0.947
M54.02 Panniculitis affecting regions of neck and back (Cervical region)	0.053	0.947
M54.01 Panniculitis affecting regions of neck and back (Occipito-atlanto-axial region)	0.053	0.947
M54.00 Panniculitis affecting regions of neck and back (Multiple sites in spine)	0.053	0.947
M54.89 Other dorsalgia (Site unspecified)	0.053	0.947
M54.88 Other dorsalgia (Sacral and sacrococcygeal region)	0.053	0.947
M54.87 Other dorsalgia (Lumbosacral region)	0.053	0.947
M54.86 Other dorsalgia (Lumbar region)	0.053	0.947
M54.85 Other dorsalgia (Thoracolumbar region)	0.053	0.947
M54.84 Other dorsalgia (Thoracic region)	0.053	0.947
M54.83 Other dorsalgia (Cervicothoracic region)	0.053	0.947
M54.82 Other dorsalgia (Cervical region)	0.053	0.947
M54.81 Other dorsalgia (Occipito-atlanto-axial region)	0.053	0.947
M54.80 Other dorsalgia (Multiple sites in spine)	0.053	0.947
M23.8 Other internal derangements of knee	0.053	0.947
M75.0 Adhesive capsulitis of shoulder	0.052	0.947
M23.9 Internal derangement of knee, unspecified	0.052	0.948
M23.6 Other spontaneous disruption of ligament(s) of knee	0.052	0.948
M23.4 Loose body in knee	0.052	0.948
M23.1 Discoid meniscus (congenital)	0.052	0.948
M23.0 Cystic meniscus	0.052	0.948
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.052	0.948
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)	0.052	0.948
M89.6 Osteopathy after poliomyelitis	0.052	0.948
M89.5 Osteolysis	0.052	0.948
M89.4 Other hypertrophic osteo-arthropathy	0.052	0.948
M89.3 Hypertrophy of bone	0.052	0.948
M89.2 Other disorders of bone development and growth	0.052	0.948
M89.1 Epiphyseal arrest	0.052	0.948
M89.0 Algoneurodystrophy	0.052	0.948
M22.10 Recurrent subluxation of patella, unspecified knee	0.051	0.948

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations