TreeWAS – Variant ID: rs1502644

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Showing all nodes without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
S82.80 Fractures of other parts of lower leg (closed)	0.055	0.945	0.000
S82.8 Fractures of other parts of lower leg	0.046	0.954	0.000
S82 Fracture of lower leg, including ankle	0.038	0.962	0.000
S82.81 Fractures of other parts of lower leg (open)	0.036	0.964	0.000
S82.0 Fracture of patella	0.035	0.965	0.000
S82.86 Maisonneuve's fracture	0.033	0.967	0.000
S82.5 Fracture of medial malleolus	0.033	0.967	0.000
S82.00 Fracture of patella (closed)	0.032	0.967	0.000
S82.4 Fracture of fibula alone	0.030	0.969	0.000
S82.1 Fracture of upper end of tibia	0.029	0.971	0.000
S82.7 Multiple fractures of lower leg	0.028	0.972	0.000
S82.50 Fracture of medial malleolus (closed)	0.028	0.972	0.000
S82.9 Fracture of lower leg, part unspecified	0.027	0.972	0.000
S82.01 Fracture of patella (open)	0.026	0.974	0.000
S82.2 Fracture of shaft of tibia	0.026	0.974	0.000
S82.40 Fracture of fibula alone (closed)	0.025	0.975	0.000
S82.51 Fracture of medial malleolus (open)	0.025	0.975	0.000
S82.3 Fracture of lower end of tibia	0.024	0.976	0.000
S82.41 Fracture of fibula alone (open)	0.022	0.978	0.000
S82.11 Fracture of upper end of tibia (open)	0.022	0.978	0.000
S82.10 Fracture of upper end of tibia (closed)	0.022	0.978	0.000
S82.70 Multiple fractures of lower leg (closed)	0.022	0.978	0.000
S82.90 Fracture of lower leg, part unspecified (closed)	0.021	0.979	0.000
S82.71 Multiple fractures of lower leg (open)	0.020	0.979	0.000
S82.21 Fracture of shaft of tibia (open)	0.020	0.980	0.000
S82.6 Fracture of lateral malleolus	0.019	0.981	0.000
S82.91 Fracture of lower leg, part unspecified (open)	0.019	0.981	0.000
S82.20 Fracture of shaft of tibia (closed)	0.017	0.983	0.000
S82.31 Fracture of lower end of tibia (open)	0.016	0.983	0.000
S82.30 Fracture of lower end of tibia (closed)	0.016	0.984	0.000
S82.61 Fracture of lateral malleolus (open)	0.013	0.986	0.000
M20.4 Other hammer toe(s) (acquired)	0.000	0.992	0.008
S82.60 Fracture of lateral malleolus (closed)	0.006	0.993	0.000
M20.1 Hallux valgus (acquired)	0.000	0.994	0.006
M20 Acquired deformities of fingers and toes	0.000	0.994	0.006
S80-S89 Injuries to the knee and lower leg	0.006	0.994	0.000
M20.6 Acquired deformity of toe(s), unspecified	0.000	0.994	0.006
S89 Other and unspecified injuries of lower leg	0.005	0.995	0.000
M20.2 Hallux rigidus	0.000	0.995	0.005
S86 Injury of muscle and tendon at lower leg level	0.004	0.996	0.000
S88 Traumatic amputation of lower leg	0.004	0.996	0.000
M20.0 Deformity of finger(s)	0.000	0.996	0.004
S87 Crushing injury of lower leg	0.004	0.996	0.000
S84 Injury of nerves at lower leg level	0.004	0.996	0.000
S85 Injury of blood vessels at lower leg level	0.004	0.996	0.000
S89.8 Other specified injuries of lower leg	0.004	0.996	0.000
S89.9 Unspecified injury of lower leg	0.004	0.996	0.000
M20.3 Other deformity of hallux (acquired)	0.000	0.996	0.004
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.004	0.996	0.000
J18.9 Pneumonia, unspecified	0.000	0.996	0.004
S81 Open wound of lower leg	0.004	0.996	0.000
S89.7 Multiple injuries of lower leg	0.003	0.996	0.000
S89.1 Other specified injuries of lower leg	0.003	0.996	0.000
S89.0 Multiple injuries of lower leg	0.003	0.996	0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.003	0.996	0.000
I21.4 Acute subendocardial myocardial infarction	0.000	0.997	0.003
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.003	0.997	0.000
S86.0 Injury of Achilles tendon	0.003	0.997	0.000
S86.7 Injury of multiple muscles and tendons at lower leg level	0.003	0.997	0.000
S88.9 Traumatic amputation of lower leg, level unspecified	0.003	0.997	0.000
S88.1 Traumatic amputation at level between knee and ankle	0.003	0.997	0.000
S88.0 Traumatic amputation at knee level	0.003	0.997	0.000
S84.9 Injury of unspecified nerve at lower leg level	0.003	0.997	0.000
S84.8 Injury of other nerves at lower leg level	0.003	0.997	0.000
S84.7 Injury of multiple nerves at lower leg level	0.003	0.997	0.000
S84.2 Injury of cutaneous sensory nerve at lower leg level	0.003	0.997	0.000
S84.0 Injury of tibial nerve at lower leg level	0.003	0.997	0.000
S87.0 Crushing injury of knee	0.003	0.997	0.000
S84.1 Injury of peroneal nerve at lower leg level	0.003	0.997	0.000
S85.9 Injury of unspecified blood vessel at lower leg level	0.003	0.997	0.000
S85.8 Injury of other blood vessels at lower leg level	0.003	0.997	0.000
S85.7 Injury of multiple blood vessels at lower leg level	0.003	0.997	0.000
S85.5 Injury of popliteal vein	0.003	0.997	0.000
S85.4 Injury of lesser saphenous vein at lower leg level	0.003	0.997	0.000
S85.3 Injury of greater saphenous vein at lower leg level	0.003	0.997	0.000
S85.2 Injury of peroneal artery	0.003	0.997	0.000
S85.0 Injury of popliteal artery	0.003	0.997	0.000
S87.8 Crushing injury of other and unspecified parts of lower leg	0.003	0.997	0.000
S86.8 Injury of other muscles and tendons at lower leg level	0.003	0.997	0.000
S85.1 Injury of (anterior)(posterior) tibial artery	0.003	0.997	0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.003	0.997	0.000
J90 Pleural effusion, not elsewhere classified	0.003	0.997	0.000
S81.8 Open wound of other parts of lower leg	0.003	0.997	0.000
S81.7 Multiple open wounds of lower leg	0.003	0.997	0.000
S81.0 Open wound of knee	0.003	0.997	0.000
S86.00 Unspecified injury of Achilles tendon	0.002	0.997	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.002	0.997	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.000	0.997	0.003
S80 Superficial injury of lower leg	0.002	0.997	0.000
Z72.0 Tobacco use	0.000	0.997	0.003
D11.0 Parotid gland	0.000	0.998	0.002
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee	0.002	0.998	0.000
S83.7 Injury to multiple structures of knee	0.002	0.998	0.000
B37.0 Candidal stomatitis	0.002	0.998	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.000	0.998	0.002
S80.7 Multiple superficial injuries of lower leg	0.002	0.998	0.000
K04.8 Radicular cyst	0.000	0.998	0.002
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.000	0.998	0.002
S81.9 Open wound of lower leg, part unspecified	0.002	0.998	0.000
D05.9 Carcinoma in situ of breast, unspecified	0.002	0.998	0.000
S83.1 Dislocation of knee	0.002	0.998	0.000
S83.0 Dislocation of patella	0.002	0.998	0.000
M20.5 Other deformities of toe(s) (acquired)	0.000	0.998	0.002
S83.3 Tear of articular cartilage of knee, current	0.002	0.998	0.000
S80.0 Contusion of knee	0.002	0.998	0.000
B37.9 Candidiasis, unspecified	0.002	0.998	0.000
O75.0 Maternal distress during labour and delivery	0.000	0.998	0.002
K09.0 Developmental odontogenic cysts	0.000	0.998	0.002
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.000	0.998	0.002
R68.8 Other specified general symptoms and signs	0.000	0.998	0.002
D22.3 Melanocytic naevi of other and unspecified parts of face	0.002	0.998	0.000
S83.6 Sprain and strain of other and unspecified parts of knee	0.001	0.998	0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.002	0.998	0.000
Z92.4 Personal history of major surgery, not elsewhere classified	0.002	0.998	0.000
I95.9 Hypotension, unspecified	0.002	0.998	0.000
L30.9 Dermatitis, unspecified	0.002	0.998	0.000
K35.9 Acute appendicitis, unspecified	0.000	0.998	0.002
S80.8 Other superficial injuries of lower leg	0.001	0.998	0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.001	0.998	0.000
S80.1 Contusion of other and unspecified parts of lower leg	0.001	0.998	0.000
G95.9 Disease of spinal cord, unspecified	0.000	0.998	0.002
S64.0 Injury of ulnar nerve at wrist and hand level	0.000	0.998	0.002
Z09.8 Follow-up examination after other treatment for other conditions	0.002	0.998	0.000
I35.0 Aortic (valve) stenosis	0.000	0.998	0.002
K66.0 Peritoneal adhesions	0.002	0.998	0.000
S19.9 Unspecified injury of neck	0.000	0.998	0.002
Z01.9 Special examination, unspecified	0.000	0.998	0.002
B37 Candidiasis	0.002	0.998	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.000	0.998	0.002
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified	0.000	0.998	0.002
L57 Skin changes due to chronic exposure to nonionising radiation	0.000	0.998	0.002
N30.9 Cystitis, unspecified	0.002	0.998	0.000
T39.0 Salicylates	0.000	0.998	0.002
M54.22 Cervicalgia (Cervical region)	0.000	0.998	0.002
B37.3 Candidiasis of vulva and vagina	0.002	0.998	0.000
C54.1 Endometrium	0.002	0.998	0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes	0.000	0.998	0.002
G61.0 Guillain-Barre syndrome	0.000	0.998	0.002
R41.0 Disorientation, unspecified	0.002	0.998	0.000
S80.9 Superficial injury of lower leg, unspecified	0.001	0.998	0.000
Z98.0 Intestinal bypass and anastomosis status	0.000	0.998	0.002
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.000	0.998	0.002
Z41.1 Other plastic surgery for unacceptable cosmetic appearance	0.002	0.998	0.000
M43.09 Spondylolysis (Site unspecified)	0.000	0.998	0.001
B37.2 Candidiasis of skin and nail	0.001	0.998	0.000
G95.0 Syringomyelia and syringobulbia	0.000	0.998	0.001
B37.1 Pulmonary candidiasis	0.001	0.998	0.000
D22.5 Melanocytic naevi of trunk	0.002	0.998	0.000
O47.1 False labour at or after 37 completed weeks of gestation	0.000	0.998	0.001
B37.7 Candidal septicaemia	0.001	0.998	0.000
B37.6 Candidal endocarditis	0.001	0.998	0.000
B37.5 Candidal meningitis	0.001	0.998	0.000
G95.8 Other specified diseases of spinal cord	0.000	0.998	0.001
L57.4 Cutis laxa senilis	0.000	0.999	0.001
L57.3 Poikiloderma of Civatte	0.000	0.999	0.001
L57.2 Cutis rhomboidalis nuchae	0.000	0.999	0.001
L57.1 Actinic reticuloid	0.000	0.999	0.001
B37.4 Candidiasis of other urogenital sites	0.001	0.999	0.000
L57.0 Actinic keratosis	0.000	0.999	0.001
G95 Other diseases of spinal cord	0.000	0.999	0.001
M54.29 Cervicalgia-Site unspe	0.000	0.999	0.001
G95.2 Cord compression, unspecified	0.000	0.999	0.001
K35.8 Acute appendicitis, other and unspecified	0.000	0.999	0.001
K35.3 Acute appendicitis with localized peritonitis	0.000	0.999	0.001
L57.5 Actinic granuloma	0.000	0.999	0.001
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
Z29.2 Other prophylactic chemotherapy	0.001	0.999	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.000	0.999	0.001
D11.9 Major salivary gland, unspecified	0.000	0.999	0.001
S83.2 Tear of meniscus, current	0.001	0.999	0.001
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
D22.4 Melanocytic naevi of scalp and neck	0.001	0.999	0.000
M94.86 Other specified disorders of cartilage (Lower leg)	0.000	0.999	0.001
G95.1 Vascular myelopathies	0.000	0.999	0.001
L05.0 Pilonidal cyst with abscess	0.000	0.999	0.001
T43.9 Psychotropic drug, unspecified	0.000	0.999	0.001
D11 Benign neoplasm of major salivary glands	0.000	0.999	0.001
T43.4 Butyrophenone and thioxanthene neuroleptics	0.000	0.999	0.001
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.000	0.999	0.001
K63.1 Perforation of intestine (nontraumatic)	0.000	0.999	0.001
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
S64.2 Injury of radial nerve at wrist and hand level	0.000	0.999	0.001
S64.1 Injury of median nerve at wrist and hand level	0.000	0.999	0.001
T43.8 Other psychotropic drugs, not elsewhere classified	0.000	0.999	0.001
K35 Acute appendicitis	0.000	0.999	0.001
F05.9 Delirium, unspecified	0.001	0.999	0.000
F60.9 Personality disorder, unspecified	0.000	0.999	0.001
O99.2 Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.000	0.999	0.001
T46.3 Coronary vasodilators, not elsewhere classified	0.000	0.999	0.001
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.001	0.999	0.000
E89.0 Postprocedural hypothyroidism	0.001	0.999	0.000
S64.3 Injury of digital nerve of thumb	0.000	0.999	0.001
S19 Other and unspecified injuries of neck	0.000	0.999	0.001
D69.5 Secondary thrombocytopenia	0.000	0.999	0.001
O99.4 Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
T43.6 Psychostimulants with abuse potential	0.000	0.999	0.001
S64 Injury of nerves at wrist and hand level	0.000	0.999	0.001
O99.7 Diseases of the skin and subcutaneous tissue complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.999	0.001
T43.5 Other and unspecified antipsychotics and neuroleptics	0.000	0.999	0.001
S92.00 Fracture of calcaneus (closed)	0.000	0.999	0.001
D11.7 Other major salivary glands	0.000	0.999	0.001
D23.6 Skin of upper limb, including shoulder	0.001	0.999	0.000
G30.9 Alzheimer's disease, unspecified	0.001	0.999	0.000
M54.2 Cervicalgia	0.000	0.999	0.001
S68.1 Traumatic amputation of other single finger (complete)(partial)	0.000	0.999	0.001
Z71.8 Other specified counselling	0.000	0.999	0.001
M43.02 Spondylolysis (Cervical region)	0.000	0.999	0.001
K04.7 Periapical abscess without sinus	0.000	0.999	0.001
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness	0.001	0.999	0.000
B18.2 Chronic viral hepatitis C	0.000	0.999	0.001
S19.8 Other specified injuries of neck	0.000	0.999	0.001
S19.7 Multiple injuries of neck	0.000	0.999	0.001
S64.9 Injury of unspecified nerve at wrist and hand level	0.000	0.999	0.001
S64.8 Injury of other nerves at wrist and hand level	0.000	0.999	0.001
T46 Poisoning by agents primarily affecting the cardiovascular system	0.000	0.999	0.001
M54.23 Cervicalgia (Cervicothoracic region)	0.000	0.999	0.001
S12.10 Fracture of second cervical vertebra (closed)	0.000	0.999	0.001
D22.0 Melanocytic naevi of lip	0.001	0.999	0.000
J84.1 Other interstitial pulmonary diseases with fibrosis	0.000	0.999	0.001
L29.9 Pruritus, unspecified	0.000	0.999	0.001
M43.0 Spondylolysis	0.000	0.999	0.001
S11.9 Open wound of neck, part unspecified	0.000	0.999	0.001
D22 Melanocytic naevi	0.001	0.999	0.000
K37 Unspecified appendicitis	0.000	0.999	0.001
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.999	0.001
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.001	0.999	0.000
M54.27 Cervicalgia-Lumbosacral	0.000	0.999	0.001
M54.26 Cervicalgia-Lumbar	0.000	0.999	0.001
M54.25 Cervicalgia-Thoracolumbar	0.000	0.999	0.001
M54.24 Cervicalgia-Thoracic	0.000	0.999	0.001
M54.20 Cervicalgia-Mult site	0.000	0.999	0.001
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000
S64.7 Injury of multiple nerves at wrist and hand level	0.000	0.999	0.001
T43.3 Phenothiazine antipsychotics and neuroleptics	0.000	0.999	0.001
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.999	0.001
M43.08 Spondylolysis (Sacral and sacrococcygeal region)	0.000	0.999	0.001
M54.28 Cervicalgia-Sacral/sacrococ	0.000	0.999	0.001
M54.49 Lumbago with sciatica (Site unspecified)	0.000	0.999	0.001
D22.9 Melanocytic naevi, unspecified	0.001	0.999	0.000
K83.1 Obstruction of bile duct	0.000	0.999	0.001
N88.9 Noninflammatory disorder of cervix uteri, unspecified	0.000	0.999	0.001
T38.9 Other and unspecified hormone antagonists	0.000	0.999	0.001
T38.7 Androgens and anabolic congeners	0.000	0.999	0.001
T38.4 Oral contraceptives	0.000	0.999	0.001
T38.2 Antithyroid drugs	0.000	0.999	0.001
T38.0 Glucocorticoids and synthetic analogues	0.000	0.999	0.001
T46.8 Antivaricose drugs, including sclerosing agents	0.000	0.999	0.001
T46.7 Peripheral vasodilators	0.000	0.999	0.001
M43.07 Spondylolysis (Lumbosacral region)	0.000	0.999	0.001
M43.05 Spondylolysis (Thoracolumbar region)	0.000	0.999	0.001
M43.04 Spondylolysis (Thoracic region)	0.000	0.999	0.001
M43.03 Spondylolysis (Cervicothoracic region)	0.000	0.999	0.001
M43.01 Spondylolysis (Occipito-atlanto-axial region)	0.000	0.999	0.001
M43.00 Spondylolysis (Multiple sites in spine)	0.000	0.999	0.001
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.000	0.999	0.001
H54.9 Unspecified visual impairment (binocular)	0.000	0.999	0.001
N87.9 Dysplasia of cervix uteri, unspecified	0.000	0.999	0.001
S12.1 Fracture of second cervical vertebra	0.000	0.999	0.001
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.000	0.999	0.001
O75 Other complications of labour and delivery, not elsewhere classified	0.000	0.999	0.001
R41 Other symptoms and signs involving cognitive functions and awareness	0.001	0.999	0.000
F60.3 Emotionally unstable personality disorder	0.000	0.999	0.001
K09.8 Other cysts of oral region, not elsewhere classified	0.000	0.999	0.001
K85.1 Biliary acute pancreatitis	0.001	0.999	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.000	0.999	0.001
T38.5 Other oestrogens and progestogens	0.000	0.999	0.001
T38.1 Thyroid hormones and substitutes	0.000	0.999	0.001
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.000	0.999	0.001
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.000	0.999	0.001
S12.11 Fracture of second cervical vertebra (open)	0.000	0.999	0.001
S52.50 Fracture of lower end of radius (closed)	0.000	0.999	0.001
K09.9 Cyst of oral region, unspecified	0.000	0.999	0.001
K35.1 Acute appendicitis with peritoneal abscess	0.000	0.999	0.001
N18.3 Chronic kidney disease, stage 3	0.001	0.999	0.000
O75.9 Complication of labour and delivery, unspecified	0.000	0.999	0.001
O75.4 Other complications of obstetric surgery and procedures	0.000	0.999	0.001
O75.3 Other infection during labour	0.000	0.999	0.001
O75.1 Shock during or following labour and delivery	0.000	0.999	0.001
T46.5 Other antihypertensive drugs, not elsewhere classified	0.000	0.999	0.001
T46.4 Angiotensin-converting-enzyme inhibitors	0.000	0.999	0.001
M94.87 Other specified disorders of cartilage (Ankle and foot)	0.000	0.999	0.001
S12.20 Fracture of other specified cervical vertebra (closed)	0.000	0.999	0.001
K35.2 Acute appendicitis with generalized peritonitis	0.000	0.999	0.001
R41.2 Retrograde amnesia	0.001	0.999	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.000	0.999	0.001
M43.06 Spondylolysis (Lumbar region)	0.000	0.999	0.001
M43.26 Other fusion of spine (Lumbar region)	0.000	0.999	0.001
S12.00 Fracture of first cervical vertebra (closed)	0.000	0.999	0.001
B18.1 Chronic viral hepatitis B without delta-agent	0.000	0.999	0.001
K04.0 Pulpitis	0.000	0.999	0.001
K38.1 Appendicular concretions	0.000	0.999	0.001
O75.5 Delayed delivery after artificial rupture of membranes	0.000	0.999	0.001
S12.2 Fracture of other specified cervical vertebra	0.000	0.999	0.001
T36.0 Penicillins	0.000	0.999	0.001
T37.8 Other specified systemic anti-infectives and antiparasitics	0.000	0.999	0.001
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.000	0.999	0.001
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.000	0.999	0.001
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.000	0.999	0.001
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.000	0.999	0.001
T44.1 Other parasympathomimetics [cholinergics]	0.000	0.999	0.001
T44.0 Anticholinesterase agents	0.000	0.999	0.001
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified	0.000	0.999	0.001
K09 Cysts of oral region, not elsewhere classified	0.000	0.999	0.001
S12.21 Fracture of other specified cervical vertebra (open)	0.000	0.999	0.001
S12.90 Fracture of neck, part unspecified (closed)	0.000	0.999	0.001
C45.0 Mesothelioma of pleura	0.001	0.999	0.000
G61.8 Other inflammatory polyneuropathies	0.000	0.999	0.001
L29.0 Pruritus ani	0.000	0.999	0.001
R41.1 Anterograde amnesia	0.001	0.999	0.000
S12.9 Fracture of neck, part unspecified	0.000	0.999	0.001
S12.0 Fracture of first cervical vertebra	0.000	0.999	0.001
T36.4 Tetracyclines	0.000	0.999	0.001
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.000	0.999	0.001
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.999	0.001
T46.1 Calcium-channel blockers	0.000	0.999	0.001
J81 Pulmonary oedema	0.001	0.999	0.000
K04 Diseases of pulp and periapical tissues	0.000	0.999	0.001
T36 Poisoning by systemic antibiotics	0.000	0.999	0.001
M43.27 Other fusion of spine (Lumbosacral region)	0.000	0.999	0.001
M94.85 Other specified disorders of cartilage (Pelvic region and thigh)	0.000	0.999	0.001
S12.01 Fracture of first cervical vertebra (open)	0.000	0.999	0.001
S12.81 Fracture of other parts of neck (open)	0.000	0.999	0.001
S12.80 Fracture of other parts of neck (closed)	0.000	0.999	0.001
S12.91 Fracture of neck, part unspecified (open)	0.000	0.999	0.001
F60.6 Anxious [avoidant] personality disorder	0.000	0.999	0.001
G61.9 Inflammatory polyneuropathy, unspecified	0.000	0.999	0.001
K04.3 Abnormal hard tissue formation in pulp	0.000	0.999	0.001
K04.2 Pulp degeneration	0.000	0.999	0.001
K04.1 Necrosis of pulp	0.000	0.999	0.001
K09.1 Developmental (nonodontogenic) cysts of oral region	0.000	0.999	0.001
S12.8 Fracture of other parts of neck	0.000	0.999	0.001
T36.9 Systemic antibiotic, unspecified	0.000	0.999	0.001
T36.8 Other systemic antibiotics	0.000	0.999	0.001
T36.7 Antifungal antibiotics, systemically used	0.000	0.999	0.001
T36.6 Rifamycins	0.000	0.999	0.001
T36.5 Aminoglycosides	0.000	0.999	0.001
T36.2 Chloramphenicol group	0.000	0.999	0.001
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.000	0.999	0.001
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.000	0.999	0.001
T37.5 Antiviral drugs	0.000	0.999	0.001
T37.4 Anthelminthics	0.000	0.999	0.001
T37.3 Other antiprotozoal drugs	0.000	0.999	0.001
T37.1 Antimycobacterial drugs	0.000	0.999	0.001
T37.0 Sulphonamides	0.000	0.999	0.001
T39.4 Antirheumatics, not elsewhere classified	0.000	0.999	0.001
T39.2 Pyrazolone derivatives	0.000	0.999	0.001
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.000	0.999	0.001
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.000	0.999	0.001
Z29.1 Prophylactic immunotherapy	0.001	0.999	0.000
G61 Inflammatory polyneuropathy	0.000	0.999	0.001
S12 Fracture of neck	0.000	0.999	0.001
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.000	0.999	0.001
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.000	0.999	0.001
M43.29 Other fusion of spine (Site unspecified)	0.000	0.999	0.001
M94.84 Other specified disorders of cartilage (Hand)	0.000	0.999	0.001
M94.83 Other specified disorders of cartilage (Forearm)	0.000	0.999	0.001
M94.82 Other specified disorders of cartilage (Upper arm)	0.000	0.999	0.001
M94.80 Other specified disorders of cartilage (Multiple sites)	0.000	0.999	0.001
D22.2 Melanocytic naevi of ear and external auricular canal	0.001	0.999	0.000
D69.8 Other specified haemorrhagic conditions	0.000	0.999	0.001
G61.1 Serum neuropathy	0.000	0.999	0.001
K04.6 Periapical abscess with sinus	0.000	0.999	0.001
M94.8 Other specified disorders of cartilage	0.000	0.999	0.001
S11.2 Open wound involving pharynx and cervical oesophagus	0.000	0.999	0.001
S11.1 Open wound involving thyroid gland	0.000	0.999	0.001
S11.0 Open wound involving larynx and trachea	0.000	0.999	0.001
S68.0 Traumatic amputation of thumb (complete)(partial)	0.000	0.999	0.001
T41.5 Therapeutic gases	0.000	0.999	0.001
T41.4 Anaesthetic, unspecified	0.000	0.999	0.001
T41.3 Local anaesthetics	0.000	0.999	0.001
T41.2 Other and unspecified general anaesthetics	0.000	0.999	0.001
T41.1 Intravenous anaesthetics	0.000	0.999	0.001
T41.0 Inhaled anaesthetics	0.000	0.999	0.001
T43.2 Other and unspecified antidepressants	0.000	0.999	0.001
T45.2 Vitamins, not elsewhere classified	0.000	0.999	0.001
T50.4 Drugs affecting uric acid metabolism	0.000	0.999	0.001
D69 Purpura and other haemorrhagic conditions	0.000	0.999	0.001
S11 Open wound of neck	0.000	0.999	0.001
T41 Poisoning by anaesthetics and therapeutic gases	0.000	0.999	0.001
T36-T50 Poisoning by drugs, medicaments and biological substances	0.000	0.999	0.001
M94.89 Other specified disorders of cartilage (Site unspecified)	0.000	0.999	0.001
S12.71 Multiple fractures of cervical spine (open)	0.000	0.999	0.001
D69.1 Qualitative platelet defects	0.000	0.999	0.001
H54.7 Unspecified visual loss	0.000	0.999	0.001
K04.4 Acute apical periodontitis of pulpal origin	0.000	0.999	0.001
R04.2 Haemoptysis	0.000	0.999	0.001
S11.8 Open wound of other parts of neck	0.000	0.999	0.001
S11.7 Multiple open wounds of neck	0.000	0.999	0.001
S64.4 Injury of digital nerve of other finger	0.000	0.999	0.001
T36.3 Macrolides	0.000	0.999	0.001
T37.2 Antimalarials and drugs acting on other blood protozoa	0.000	0.999	0.001
T45.5 Anticoagulants	0.000	0.999	0.001
T47.4 Other laxatives	0.000	0.999	0.001
T47.2 Stimulant laxatives	0.000	0.999	0.001
T49.9 Topical agent, unspecified	0.000	0.999	0.001
T49.8 Other topical agents	0.000	0.999	0.001
T49.7 Dental drugs, topically applied	0.000	0.999	0.001
T49.6 Otorhinolaryngological drugs and preparations	0.000	0.999	0.001
T49.5 Ophthalmological drugs and preparations	0.000	0.999	0.001
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.000	0.999	0.001
T49.3 Emollients, demulcents and protectants	0.000	0.999	0.001
T49.2 Local astringents and local detergents	0.000	0.999	0.001
T49.1 Antipruritics	0.000	0.999	0.001
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.000	0.999	0.001
T50.1 Loop [high-ceiling] diuretics	0.000	0.999	0.001
Z89.4 Acquired absence of foot and ankle	0.001	0.999	0.000
Z97.8 Presence of other specified devices	0.000	0.999	0.001
Z98.8 Other specified postsurgical states	0.000	0.999	0.001
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.000	0.999	0.001
M43.28 Other fusion of spine (Sacral and sacrococcygeal region)	0.000	0.999	0.001
M43.25 Other fusion of spine (Thoracolumbar region)	0.000	0.999	0.001
M43.24 Other fusion of spine (Thoracic region)	0.000	0.999	0.001
M43.23 Other fusion of spine (Cervicothoracic region)	0.000	0.999	0.001
M43.22 Other fusion of spine (Cervical region)	0.000	0.999	0.001
M43.21 Other fusion of spine (Occipito-atlanto-axial region)	0.000	0.999	0.001
M43.20 Other fusion of spine (Multiple sites in spine)	0.000	0.999	0.001
M94.81 Other specified disorders of cartilage (Shoulder region)	0.000	0.999	0.001
D22.1 Melanocytic naevi of eyelid, including canthus	0.001	0.999	0.000
D69.9 Haemorrhagic condition, unspecified	0.000	0.999	0.001
G30.1 Alzheimer's disease with late onset	0.001	0.999	0.000
G30.0 Alzheimer's disease with early onset	0.001	0.999	0.000
J18.8 Other pneumonia, organism unspecified	0.000	0.999	0.001
J84.8 Other specified interstitial pulmonary diseases	0.000	0.999	0.001
R41.3 Other amnesia	0.001	0.999	0.000
S12.7 Multiple fractures of cervical spine	0.000	0.999	0.001
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.000	0.999	0.001
T45.9 Primarily systemic and haematological agent, unspecified	0.000	0.999	0.001
T45.8 Other primarily systemic and haematological agents	0.000	0.999	0.001
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.000	0.999	0.001
T45.6 Fibrinolysis-affecting drugs	0.000	0.999	0.001
T45.3 Enzymes, not elsewhere classified	0.000	0.999	0.001
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.000	0.999	0.001
T47.8 Other agents primarily affecting the gastro-intestinal system	0.000	0.999	0.001
T47.7 Emetics	0.000	0.999	0.001
T47.6 Antidiarrhoeal drugs	0.000	0.999	0.001
T47.5 Digestants	0.000	0.999	0.001
T47.3 Saline and osmotic laxatives	0.000	0.999	0.001
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.000	0.999	0.001
T48.5 Anti-common-cold drugs	0.000	0.999	0.001
T48.4 Expectorants	0.000	0.999	0.001
T48.3 Antitussives	0.000	0.999	0.001
T48.2 Other and unspecified agents primarily acting on muscles	0.000	0.999	0.001
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.000	0.999	0.001
T48.0 Oxytocic drugs	0.000	0.999	0.001
T79.6 Traumatic ischaemia of muscle	0.001	0.999	0.000
Z71.6 Tobacco abuse counselling	0.000	0.999	0.001
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.000	0.999	0.001
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.000	0.999	0.001
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.000	0.999	0.001
D69.4 Other primary thrombocytopenia	0.000	0.999	0.001
F60.4 Histrionic personality disorder	0.000	0.999	0.001
F60.1 Schizoid personality disorder	0.000	0.999	0.001
H04.1 Other disorders of lachrymal gland	0.001	0.999	0.000
J18.2 Hypostatic pneumonia, unspecified	0.000	0.999	0.001
K09.2 Other cysts of jaw	0.000	0.999	0.001
M43.2 Other fusion of spine	0.000	0.999	0.001
M50.1 Cervical disk disorder with radiculopathy	0.001	0.999	0.000
O75.2 Pyrexia during labour, not elsewhere classified	0.000	0.999	0.001
S40.9 Superficial injury of shoulder and upper arm, unspecified	0.000	0.999	0.001
T45.4 Iron and its compounds	0.000	0.999	0.001
T45.0 Antiallergic and antiemetic drugs	0.000	0.999	0.001
T47.0 Histamine H(2)-receptor antagonists	0.000	0.999	0.001
T50.8 Diagnostic agents	0.000	0.999	0.001
T50.7 Analeptics and opioid receptor antagonists	0.000	0.999	0.001
T50.6 Antidotes and chelating agents, not elsewhere classified	0.000	0.999	0.001
T50.5 Appetite depressants	0.000	0.999	0.001
T50.3 Electrolytic, caloric and water-balance agents	0.000	0.999	0.001
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.000	0.999	0.001
T50.0 Mineralocorticoids and their antagonists	0.000	0.999	0.001
Z41.8 Other procedures for purposes other than remedying health state	0.001	0.999	0.000
L84 Corns and callosities	0.001	0.999	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.000	0.999	0.001
M53.38 Sacrococcygeal disorders, not elsewhere classified-Sacral/s	0.000	0.999	0.001
S12.70 Multiple fractures of cervical spine (closed)	0.000	0.999	0.001
C85.9 Non-Hodgkin's lymphoma, unspecified type	0.000	0.999	0.001
D69.6 Thrombocytopenia, unspecified	0.000	0.999	0.001
D69.2 Other nonthrombocytopenic purpura	0.000	0.999	0.001
F60.2 Dissocial personality disorder	0.000	0.999	0.001
F60.0 Paranoid personality disorder	0.000	0.999	0.001
G37.9 Demyelinating disease of central nervous system, unspecified	0.001	0.999	0.000
J84.9 Interstitial pulmonary disease, unspecified	0.000	0.999	0.001
L30.4 Erythema intertrigo	0.001	0.999	0.000
L59.8 Other specified disorders of skin and subcutaneous tissue related to radiation	0.000	0.999	0.001
R87.6 Abnormal cytological findings	0.001	0.999	0.000
S10.9 Superficial injury of neck, part unspecified	0.000	0.999	0.001
S10.8 Superficial injury of other parts of neck	0.000	0.999	0.001
S10.7 Multiple superficial injuries of neck	0.000	0.999	0.001
S10.1 Other and unspecified superficial injuries of throat	0.000	0.999	0.001
S10.0 Contusion of throat	0.000	0.999	0.001
T42.1 Iminostilbenes	0.000	0.999	0.001
T48.6 Antiasthmatics, not elsewhere classified	0.000	0.999	0.001
F60 Specific personality disorders	0.000	0.999	0.001
J18 Pneumonia, organism unspecified	0.000	0.999	0.001
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.000	0.999	0.001
M43.86 Other specified deforming dorsopathies (Lumbar region)	0.000	0.999	0.001
M94.88 Other specified disorders of cartilage (Other)	0.000	0.999	0.001

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations