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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs154977
log Bayes Factor = 164.311
Chromosome 6   position 32,900,018  (GRCh37) Explore rs154977 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
K90.0 Coeliac disease
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
G35 Multiple sclerosis
1.000 0.000 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
M05 Seropositive rheumatoid arthritis
0.000 0.001 0.999
M05-M14 Inflammatory polyarthropathies
0.000 0.001 0.999
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.998 0.002 0.000
E20-E35 Disorders of other endocrine glands
0.998 0.002 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.998 0.002 0.000
Chapter VI Diseases of the nervous system
0.996 0.004 0.000
L40.9 Psoriasis, unspecified
0.000 0.005 0.995
D60-D64 Aplastic and other anaemias
0.995 0.005 0.000
D64 Other anaemias
0.995 0.005 0.000
D64.9 Anaemia, unspecified
0.992 0.008 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.009 0.991
E27 Other disorders of adrenal gland
0.991 0.009 0.000
E27.1 Primary adrenocortical insufficiency
0.989 0.011 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.984 0.016 0.000
K90 Intestinal malabsorption
0.974 0.026 0.000
R31 Unspecified haematuria
0.000 0.029 0.971
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.029 0.971
D50-D53 Nutritional anaemias
0.970 0.030 0.000
E10-E14 Diabetes mellitus
0.966 0.034 0.000
E10 Insulin-dependent diabetes mellitus
0.964 0.036 0.000
K70-K77 Diseases of liver
0.962 0.038 0.000
M07 Psoriatic and enteropathic arthropathies
0.000 0.038 0.962
Chapter XI Diseases of the digestive system
0.960 0.040 0.000
K90-K93 Other diseases of the digestive system
0.959 0.041 0.000
K75 Other inflammatory liver diseases
0.957 0.043 0.000
M06.0 Seronegative rheumatoid arthritis
0.000 0.046 0.954
Chapter XII Diseases of the skin and subcutaneous tissue
0.954 0.046 0.000
E50-E64 Other nutritional deficiencies
0.952 0.048 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.050 0.950
L10-L14 Bullous disorders
0.950 0.050 0.000
E10.3 With ophthalmic complications
0.947 0.053 0.000
K75.4 Autoimmune hepatitis
0.945 0.055 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.944 0.056 0.000
L13 Other bullous disorders
0.942 0.058 0.000
Q60-Q64 Congenital malformations of the urinary system
0.941 0.059 0.000
D69 Purpura and other haemorrhagic conditions
0.940 0.060 0.000
L13.0 Dermatitis herpetiformis
0.937 0.063 0.000
E10.1 With ketoacidosis
0.934 0.066 0.000
M07.3 Other psoriatic arthropathies
0.000 0.067 0.933
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.927 0.073 0.000
D64.8 Other specified anaemias
0.917 0.083 0.000
E34 Other endocrine disorders
0.913 0.087 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.909 0.091 0.000
K72 Hepatic failure, not elsewhere classified
0.905 0.095 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.903 0.097 0.000
D51 Vitamin B12 deficiency anaemia
0.900 0.100 0.000
D69.6 Thrombocytopenia, unspecified
0.899 0.101 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.104 0.896
M06.3 Rheumatoid nodule
0.000 0.106 0.894
K75.8 Other specified inflammatory liver diseases
0.890 0.110 0.000
L50-L54 Urticaria and erythema
0.889 0.111 0.000
E10.2 With renal complications
0.888 0.112 0.000
K74 Fibrosis and cirrhosis of liver
0.884 0.116 0.000
D80-D89 Certain disorders involving the immune mechanism
0.879 0.121 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.878 0.122 0.000
E53 Deficiency of other B group vitamins
0.877 0.123 0.000
G20-G26 Extrapyramidal and movement disorders
0.876 0.124 0.000
Q44.6 Cystic disease of liver
0.874 0.126 0.000
D52 Folate deficiency anaemia
0.872 0.128 0.000
Q43 Other congenital malformations of intestine
0.871 0.129 0.000
Q61 Cystic kidney disease
0.868 0.132 0.000
K73 Chronic hepatitis, not elsewhere classified
0.860 0.140 0.000
Chapter I Certain infectious and parasitic diseases
0.858 0.142 0.000
L11 Other acantholytic disorders
0.857 0.143 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.147 0.853
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.850 0.150 0.000
E28 Ovarian dysfunction
0.847 0.153 0.000
Q27 Other congenital malformations of peripheral vascular system
0.845 0.155 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.841 0.159 0.000
K72.0 Acute and subacute hepatic failure
0.840 0.160 0.000
L57 Skin changes due to chronic exposure to nonionising radiation
0.839 0.161 0.000
G24 Dystonia
0.837 0.163 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.833 0.167 0.000
E20 Hypoparathyroidism
0.832 0.168 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.169 0.831
D69.4 Other primary thrombocytopenia
0.830 0.170 0.000
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.828 0.172 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.828 0.172 0.000
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.827 0.173 0.000
K74.0 Hepatic fibrosis
0.826 0.174 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.822 0.178 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.182 0.818
D69.8 Other specified haemorrhagic conditions
0.818 0.182 0.000
A63.0 Anogenital (venereal) warts
0.818 0.182 0.000
B07 Viral warts
0.818 0.182 0.000
E06 Thyroiditis
0.817 0.183 0.000
L53 Other erythematous conditions
0.816 0.184 0.000
K74.6 Other and unspecified cirrhosis of liver
0.816 0.184 0.000
E53.8 Deficiency of other specified B group vitamins
0.813 0.187 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.812 0.188 0.000
L40 Psoriasis
0.035 0.188 0.777
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.192 0.808
E58 Dietary calcium deficiency
0.807 0.193 0.000
Q40 Other congenital malformations of upper alimentary tract
0.806 0.194 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.805 0.195 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.802 0.198 0.000
D69.9 Haemorrhagic condition, unspecified
0.802 0.198 0.000
D52.9 Folate deficiency anaemia, unspecified
0.802 0.198 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.200 0.800
E27.2 Addisonian crisis
0.799 0.201 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.798 0.202 0.000
D53 Other nutritional anaemias
0.795 0.205 0.000
K75.0 Abscess of liver
0.789 0.211 0.000
E51 Thiamine deficiency
0.788 0.212 0.000
E22 Hyperfunction of pituitary gland
0.787 0.213 0.000
Chapter XXII Codes for special purposes
0.786 0.214 0.000
Q27.3 Peripheral arteriovenous malformation
0.785 0.215 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.215 0.785
L52 Erythema nodosum
0.782 0.218 0.000
M06.4 Inflammatory polyarthropathy
0.000 0.219 0.781
G24.9 Dystonia, unspecified
0.780 0.220 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.776 0.224 0.000
E34.9 Endocrine disorder, unspecified
0.773 0.227 0.000
Q64 Other congenital malformations of urinary system
0.773 0.227 0.000
L11.0 Acquired keratosis follicularis
0.772 0.228 0.000
E31 Polyglandular dysfunction
0.770 0.230 0.000
Q61.2 Polycystic kidney, adult type
0.768 0.232 0.000
E10.0 With coma
0.768 0.232 0.000
E55 Vitamin D deficiency
0.767 0.232 0.000
Q35-Q37 Cleft lip and cleft palate
0.761 0.239 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.240 0.760
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.242 0.758
Q25 Congenital malformations of great arteries
0.755 0.245 0.000
E40-E46 Malnutrition
0.755 0.245 0.000
Q61.9 Cystic kidney disease, unspecified
0.750 0.250 0.000
G37 Other demyelinating diseases of central nervous system
0.750 0.250 0.000
L40.5 Arthropathic psoriasis
0.001 0.251 0.748
M14 Arthropathies in other diseases classified elsewhere
0.000 0.252 0.748
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.748 0.252 0.000
Q43.9 Congenital malformation of intestine, unspecified
0.747 0.253 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.254 0.746
Q30-Q34 Congenital malformations of the respiratory system
0.744 0.255 0.000
G00 Bacterial meningitis, not elsewhere classified
0.742 0.258 0.000
B00 Herpesviral [herpes simplex] infections
0.741 0.258 0.000
A80-A89 Viral infections of the central nervous system
0.741 0.259 0.000
K90.9 Intestinal malabsorption, unspecified
0.741 0.259 0.000
Q23 Congenital malformations of aortic and mitral valves
0.739 0.261 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.262 0.738
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.738 0.262 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.738 0.262 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.737 0.263 0.000
E34.8 Other specified endocrine disorders
0.737 0.263 0.000
G36 Other acute disseminated demyelination
0.736 0.264 0.000
E28.2 Polycystic ovarian syndrome
0.734 0.266 0.000
L53.9 Erythematous condition, unspecified
0.734 0.266 0.000
Q43.3 Congenital malformations of intestinal fixation
0.733 0.267 0.000
Q14 Congenital malformations of posterior segment of eye
0.733 0.267 0.000
E07 Other disorders of thyroid
0.732 0.268 0.000
Q44.5 Other congenital malformations of bile ducts
0.730 0.270 0.000
E10.4 With neurological complications
0.730 0.270 0.000
G58 Other mononeuropathies
0.729 0.271 0.000
E27.8 Other specified disorders of adrenal gland
0.729 0.271 0.000
K77 Liver disorders in diseases classified elsewhere
0.729 0.271 0.000
L56 Other acute skin changes due to ultraviolet radiation
0.729 0.271 0.000
M05.8 Other seropositive rheumatoid arthritis
0.000 0.271 0.728
M06.34 Rheumatoid nodule (Hand)
0.000 0.272 0.728
Q39 Congenital malformations of oesophagus
0.726 0.274 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.725 0.275 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.276 0.724
G24.5 Blepharospasm
0.723 0.277 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.722 0.278 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.279 0.721
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.279 0.721
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.716
E34.0 Carcinoid syndrome
0.716 0.284 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.715 0.284 0.000
E32 Diseases of thymus
0.715 0.284 0.000
E30 Disorders of puberty, not elsewhere classified
0.715 0.284 0.000
K72.9 Hepatic failure, unspecified
0.715 0.285 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.715 0.285 0.000
E10.8 With unspecified complications
0.714 0.286 0.000
E06.5 Other chronic thyroiditis
0.714 0.286 0.000
D64.4 Congenital dyserythropoietic anaemia
0.713 0.287 0.000
D64.3 Other sideroblastic anaemias
0.713 0.287 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.713 0.287 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.713 0.287 0.000
D64.0 Hereditary sideroblastic anaemia
0.713 0.287 0.000
E20.9 Hypoparathyroidism, unspecified
0.712 0.288 0.000
M05.2 Rheumatoid vasculitis
0.000 0.288 0.711
E27.5 Adrenomedullary hyperfunction
0.710 0.290 0.000
E27.0 Other adrenocortical overactivity
0.710 0.290 0.000
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.290 0.710
D67 Hereditary factor IX deficiency
0.709 0.291 0.000
Q61.3 Polycystic kidney, unspecified
0.708 0.292 0.000
Q43.8 Other specified congenital malformations of intestine
0.707 0.293 0.000
Q27.9 Congenital malformation of peripheral vascular system, unspecified
0.706 0.294 0.000
L58 Radiodermatitis
0.706 0.294 0.000
B01 Varicella [chickenpox]
0.706 0.294 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.705 0.294 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.705 0.294 0.000
Q74 Other congenital malformations of limb(s)
0.704 0.296 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.704 0.296 0.000
Q45 Other congenital malformations of digestive system
0.703 0.297 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.703 0.297 0.000
M12 Other specific arthropathies
0.000 0.297 0.703
M07.6 Other enteropathic arthropathies
0.000 0.299 0.701
K71 Toxic liver disease
0.700 0.300 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.700 0.300 0.000
Chapter V Mental and behavioural disorders
0.699 0.301 0.000
K90.3 Pancreatic steatorrhoea
0.698 0.302 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.698 0.302 0.000
K90.1 Tropical sprue
0.698 0.302 0.000
E26 Hyperaldosteronism
0.698 0.302 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.697 0.303 0.000
Q18 Other congenital malformations of face and neck
0.697 0.303 0.000
G70-G73 Diseases of myoneural junction and muscle
0.695 0.305 0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.307 0.693
E12 Malnutrition-related diabetes mellitus
0.692 0.308 0.000
E34.3 Short stature, not elsewhere classified
0.692 0.308 0.000
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.692 0.308 0.000
D69.1 Qualitative platelet defects
0.692 0.308 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.309 0.691
M07.5 Arthropathy in ulcerative colitis
0.000 0.311 0.689
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.311 0.689
M07.2 Psoriatic spondylitis
0.000 0.311 0.689
M07.1 Arthritis mutilans
0.000 0.311 0.689
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.311 0.689
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.689 0.311 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.688 0.312 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.687 0.313 0.000
K75.2 Nonspecific reactive hepatitis
0.686 0.314 0.000
K75.1 Phlebitis of portal vein
0.686 0.314 0.000
K72.1 Chronic hepatic failure
0.686 0.314 0.000
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.316 0.684
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.316 0.684
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.316 0.684
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.316 0.684
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.316 0.684
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.316 0.684
D69.0 Allergic purpura
0.684 0.316 0.000
G58.8 Other specified mononeuropathies
0.684 0.316 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.682 0.317 0.000
E63 Other nutritional deficiencies
0.682 0.317 0.000
E50 Vitamin A deficiency
0.682 0.317 0.000
E60 Dietary zinc deficiency
0.682 0.317 0.000
E59 Dietary selenium deficiency
0.682 0.317 0.000
E54 Ascorbic acid deficiency
0.682 0.317 0.000
E52 Niacin deficiency [pellagra]
0.682 0.317 0.000
L10 Pemphigus
0.681 0.319 0.000
L14 Bullous disorders in diseases classified elsewhere
0.681 0.319 0.000
Q12 Congenital lens malformations
0.680 0.319 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.680 0.320 0.000
F03 Unspecified dementia
0.680 0.320 0.000
G21 Secondary Parkinsonism
0.679 0.320 0.000
G24.1 Idiopathic familial dystonia
0.679 0.321 0.000
Q17 Other congenital malformations of ear
0.679 0.321 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.676 0.324 0.000
L13.9 Bullous disorder, unspecified
0.675 0.324 0.000
L13.8 Other specified bullous disorders
0.675 0.324 0.000
L13.1 Subcorneal pustular dermatitis
0.675 0.324 0.000
B00.5 Herpesviral ocular disease
0.674 0.326 0.000
B15-B19 Viral hepatitis
0.674 0.326 0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.326 0.674
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.326 0.673
D63.8 Anaemia in other chronic diseases classified elsewhere
0.672 0.328 0.000
G30-G32 Other degenerative diseases of the nervous system
0.671 0.329 0.000
E53.9 Vitamin B deficiency, unspecified
0.671 0.329 0.000
E51.2 Wernicke's encephalopathy
0.670 0.329 0.000
A86 Unspecified viral encephalitis
0.670 0.329 0.000
K74.1 Hepatic sclerosis
0.670 0.330 0.000
D53.9 Nutritional anaemia, unspecified
0.670 0.330 0.000
M07.38 Other psoriatic arthropathies (Other)
0.000 0.331 0.669
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.331 0.669
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.331 0.669
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.331 0.669
L11.1 Transient acantholytic dermatosis [Grover]
0.669 0.331 0.000
D69.2 Other nonthrombocytopenic purpura
0.669 0.331 0.000
Q78 Other osteochondrodysplasias
0.667 0.332 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.667 0.333 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.334 0.666
Q44.7 Other congenital malformations of liver
0.665 0.335 0.000
Q44.4 Choledochal cyst
0.665 0.335 0.000
Q44.3 Congenital stenosis and stricture of bile ducts
0.665 0.335 0.000
Q44.2 Atresia of bile ducts
0.665 0.335 0.000
Q44.1 Other congenital malformations of gallbladder
0.665 0.335 0.000
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder
0.665 0.335 0.000
M11 Other crystal arthropathies
0.000 0.336 0.664
M08 Juvenile arthritis
0.000 0.336 0.664
E25 Adrenogenital disorders
0.662 0.337 0.000
G58.9 Mononeuropathy, unspecified
0.662 0.338 0.000
E29 Testicular dysfunction
0.662 0.338 0.000
F01 Vascular dementia
0.661 0.339 0.000
E10.7 With multiple complications
0.660 0.339 0.000
Q64.3 Other atresia and stenosis of urethra and bladder neck
0.660 0.340 0.000
E23 Hypofunction and other disorders of pituitary gland
0.659 0.341 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.655 0.344 0.000
M06.1 Adult-onset Still's disease
0.000 0.345 0.655
E34.5 Androgen resistance syndrome
0.654 0.346 0.000
E34.4 Constitutional tall stature
0.654 0.346 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.654 0.346 0.000
E34.1 Other hypersecretion of intestinal hormones
0.654 0.346 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.654 0.346 0.000
B08 Other viral infections characterised by skin and mucous membrane lesions, not elsewhere classified
0.653 0.347 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.652 0.348 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.348 0.652
Q26 Congenital malformations of great veins
0.651 0.349 0.000
Q20 Congenital malformations of cardiac chambers and connexions
0.651 0.349 0.000
D82 Immunodeficiency associated with other major defects
0.651 0.349 0.000
Q40.2 Other specified congenital malformations of stomach
0.650 0.350 0.000
D89.1 Cryoglobulinaemia
0.648 0.352 0.000
A60 Anogenital herpesviral [herpes simplex] infections
0.648 0.352 0.000
L53.8 Other specified erythematous conditions
0.647 0.353 0.000
L55 Sunburn
0.647 0.353 0.000
G00.9 Bacterial meningitis, unspecified
0.646 0.354 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.645 0.355 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.645 0.355 0.000
D51.2 Transcobalamin II deficiency
0.645 0.355 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.645 0.355 0.000
B02 Zoster [herpes zoster]
0.644 0.356 0.000
L51 Erythema multiforme
0.643 0.356 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.641 0.358 0.000
D83 Common variable immunodeficiency
0.641 0.359 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.359 0.641
M06.38 Rheumatoid nodule (Other)
0.000 0.359 0.641
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.359 0.641
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.359 0.641
M06.33 Rheumatoid nodule (Forearm)
0.000 0.359 0.641
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.359 0.641
U89 Agent resistant to other and unspecified antibiotics
0.641 0.359 0.000
F01.9 Vascular dementia, unspecified
0.640 0.360 0.000
K73.9 Chronic hepatitis, unspecified
0.640 0.360 0.000
L54 Erythema in diseases classified elsewhere
0.638 0.362 0.000
Q00-Q07 Congenital malformations of the nervous system
0.637 0.363 0.000
E56 Other vitamin deficiencies
0.637 0.363 0.000
E55.9 Vitamin D deficiency, unspecified
0.635 0.365 0.000
K74.4 Secondary biliary cirrhosis
0.634 0.366 0.000
K74.2 Hepatic fibrosis with hepatic sclerosis
0.634 0.366 0.000
E05.8 Other thyrotoxicosis
0.631 0.369 0.000
D81 Combined immunodeficiencies
0.630 0.369 0.000
D80 Immunodeficiency with predominantly antibody defects
0.630 0.370 0.000
Q16 Congenital malformations of ear causing impairment of hearing
0.629 0.371 0.000
Q13 Congenital malformations of anterior segment of eye
0.629 0.371 0.000
Q14.1 Congenital malformation of retina
0.629 0.371 0.000
E53.1 Pyridoxine deficiency
0.629 0.371 0.000
E53.0 Riboflavin deficiency
0.629 0.371 0.000
Q24 Other congenital malformations of heart
0.628 0.372 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.628 0.372 0.000
G22 Parkinsonism in diseases classified elsewhere
0.628 0.372 0.000
B00.8 Other forms of herpesviral infection
0.627 0.373 0.000
D52.8 Other folate deficiency anaemias
0.625 0.375 0.000
D52.1 Drug-induced folate deficiency anaemia
0.625 0.375 0.000
D52.0 Dietary folate deficiency anaemia
0.625 0.375 0.000
Q43.7 Persistent cloaca
0.624 0.376 0.000
Q43.6 Congenital fistula of rectum and anus
0.624 0.376 0.000
Q43.5 Ectopic anus
0.624 0.376 0.000
Q43.4 Duplication of intestine
0.624 0.376 0.000
Q43.2 Other congenital functional disorders of colon
0.624 0.376 0.000
G04 Encephalitis, myelitis and encephalomyelitis
0.624 0.376 0.000
Q11 Anophthalmos, microphthalmos and macrophthalmos
0.624 0.376 0.000
E06.9 Thyroiditis, unspecified
0.623 0.376 0.000
L40-L45 Papulosquamous disorders
0.397 0.377 0.226
Q61.8 Other cystic kidney diseases
0.622 0.378 0.000
Q61.1 Polycystic kidney, infantile type
0.622 0.378 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.622 0.378 0.000
Q23.1 Congenital insufficiency of aortic valve
0.622 0.378 0.000
Q38.1 Ankyloglossia
0.621 0.379 0.000
L12 Pemphigoid
0.621 0.379 0.000
Q40.8 Other specified congenital malformations of upper alimentary tract
0.620 0.380 0.000
B16 Acute hepatitis B
0.619 0.381 0.000
L59 Other disorders of skin and subcutaneous tissue related to radiation
0.619 0.381 0.000
E28.3 Primary ovarian failure
0.618 0.382 0.000
K75.3 Granulomatous hepatitis, not elsewhere classified
0.617 0.382 0.000
G53.0 Postzoster neuralgia
0.617 0.383 0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.617 0.383 0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.617 0.383 0.000
E13 Other specified diabetes mellitus
0.617 0.383 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.384 0.616
Q61.5 Medullary cystic kidney
0.616 0.384 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.615 0.384 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.615 0.384 0.000
A75-A79 Rickettsioses
0.615 0.384 0.000
A70-A74 Other diseases caused by chlamydiae
0.615 0.384 0.000
A20-A28 Certain zoonotic bacterial diseases
0.615 0.384 0.000
L11.9 Acantholytic disorder, unspecified
0.615 0.385 0.000
L11.8 Other specified acantholytic disorders
0.615 0.385 0.000
L53.0 Toxic erythema
0.615 0.385 0.000
Q68 Other congenital musculoskeletal deformities
0.613 0.387 0.000
Q43.1 Hirschsprung's disease
0.611 0.389 0.000
A65-A69 Other spirochaetal diseases
0.610 0.390 0.000
M14.6 Neuropathic arthropathy
0.000 0.390 0.610
B06 Rubella [German measles]
0.610 0.390 0.000
B05 Measles
0.610 0.390 0.000
B09 Unspecified viral infection characterised by skin and mucous membrane lesions
0.610 0.390 0.000
B04 Monkeypox
0.610 0.390 0.000
B03 Smallpox
0.610 0.390 0.000
U89.8 Agent resistant to other single specified antibiotic
0.608 0.392 0.000
A80 Acute poliomyelitis
0.608 0.392 0.000
E28.9 Ovarian dysfunction, unspecified
0.607 0.392 0.000
E28.8 Other ovarian dysfunction
0.607 0.392 0.000
E28.1 Androgen excess
0.607 0.392 0.000
E28.0 Oestrogen excess
0.607 0.392 0.000
D50 Iron deficiency anaemia
0.607 0.393 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.607 0.393 0.000
B00.9 Herpesviral infection, unspecified
0.607 0.393 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.607 0.393 0.000
Q25.0 Patent ductus arteriosus
0.607 0.393 0.000
Q61.4 Renal dysplasia
0.606 0.394 0.000
E31.0 Autoimmune polyglandular failure
0.606 0.394 0.000
Q27.4 Congenital phlebectasia
0.606 0.394 0.000
Q27.2 Other congenital malformations of renal artery
0.606 0.394 0.000
Q27.1 Congenital renal artery stenosis
0.606 0.394 0.000
Q27.0 Congenital absence and hypoplasia of umbilical artery
0.606 0.394 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.394 0.606
Q28 Other congenital malformations of circulatory system
0.605 0.395 0.000
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit
0.604 0.395 0.000
A59 Trichomoniasis
0.603 0.397 0.000
A56 Other sexually transmitted chlamydial diseases
0.603 0.397 0.000
A54 Gonococcal infection
0.603 0.397 0.000
A53 Other and unspecified syphilis
0.603 0.397 0.000
A51 Early syphilis
0.603 0.397 0.000
A50 Congenital syphilis
0.603 0.397 0.000
A64 Unspecified sexually transmitted disease
0.603 0.397 0.000
A58 Granuloma inguinale
0.603 0.397 0.000
A57 Chancroid
0.603 0.397 0.000
A55 Chlamydial lymphogranuloma (venereum)
0.603 0.397 0.000
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.602 0.398 0.000
E07.8 Other specified disorders of thyroid
0.602 0.398 0.000
B01.9 Varicella without complications
0.602 0.398 0.000
L57.5 Actinic granuloma
0.602 0.398 0.000
L57.3 Poikiloderma of Civatte
0.602 0.398 0.000
L57.2 Cutis rhomboidalis nuchae
0.602 0.398 0.000
L57.1 Actinic reticuloid
0.602 0.398 0.000
A15-A19 Tuberculosis
0.601 0.399 0.000
D89.2 Hypergammaglobulinaemia, unspecified
0.601 0.399 0.000
G58.7 Mononeuritis multiplex
0.601 0.399 0.000
G20 Parkinson's disease
0.601 0.399 0.000
G24.4 Idiopathic orofacial dystonia
0.600 0.400 0.000
G24.2 Idiopathic nonfamilial dystonia
0.600 0.400 0.000
G24.0 Drug-induced dystonia
0.600 0.400 0.000
G23 Other degenerative diseases of basal ganglia
0.600 0.400 0.000
G24.8 Other dystonia
0.599 0.400 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.598 0.401 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.598 0.402 0.000
K65-K67 Diseases of peritoneum
0.598 0.402 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.597 0.403 0.000
E20.8 Other hypoparathyroidism
0.596 0.404 0.000
E20.1 Pseudohypoparathyroidism
0.596 0.404 0.000
E20.0 Idiopathic hypoparathyroidism
0.596 0.404 0.000
Q63 Other congenital malformations of kidney
0.595 0.405 0.000
A52 Late syphilis
0.595 0.405 0.000
Q15 Other congenital malformations of eye
0.594 0.405 0.000
G37.8 Other specified demyelinating diseases of central nervous system
0.593 0.406 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.593 0.407 0.000
Q25.7 Other congenital malformations of pulmonary artery
0.593 0.407 0.000
Q62.5 Duplication of ureter
0.592 0.408 0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.590 0.410 0.000
Q75 Other congenital malformations of skull and face bones
0.589 0.411 0.000
Q73 Reduction defects of unspecified limb
0.589 0.411 0.000
Q72 Reduction defects of lower limb
0.589 0.411 0.000
Q71 Reduction defects of upper limb
0.589 0.411 0.000
Q70 Syndactyly
0.589 0.411 0.000
Q69 Polydactyly
0.589 0.411 0.000
D86 Sarcoidosis
0.589 0.411 0.000
E10.6 With other specified complications
0.588 0.411 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.588 0.412 0.000
Q74.0 Other congenital malformations of upper limb(s), including shoulder girdle
0.587 0.413 0.000
L40.8 Other psoriasis
0.022 0.413 0.565
Q25.6 Stenosis of pulmonary artery
0.586 0.414 0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine
0.586 0.414 0.000
E06.4 Drug-induced thyroiditis
0.586 0.414 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.586 0.414 0.000
E06.1 Subacute thyroiditis
0.586 0.414 0.000
E06.0 Acute thyroiditis
0.586 0.414 0.000
B02.2 Zoster with other nervous system involvement
0.585 0.415 0.000
L53.3 Other chronic figurate erythema
0.585 0.415 0.000
L53.2 Erythema marginatum
0.585 0.415 0.000
L53.1 Erythema annulare centrifugum
0.585 0.415 0.000
E23.2 Diabetes insipidus
0.585 0.415 0.000
Q35 Cleft palate
0.584 0.416 0.000
D89.3 Immune reconstitution syndrome
0.582 0.417 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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