TreeWAS – Variant ID: rs17631303

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M16.9 Coxarthrosis, unspecified	0.998	0.002	0.000
M16 Coxarthrosis [arthrosis of hip]	0.997	0.003	0.000
M16.1 Other primary coxarthrosis	0.995	0.005	0.000
K60.1 Chronic anal fissure	0.987	0.013	0.000
K60 Fissure and fistula of anal and rectal regions	0.983	0.017	0.000
K60.2 Anal fissure, unspecified	0.982	0.018	0.000
M20 Acquired deformities of fingers and toes	0.949	0.051	0.000
M20.5 Other deformities of toe(s) (acquired)	0.947	0.053	0.000
M20.2 Hallux rigidus	0.937	0.063	0.000
M16.3 Other dysplastic coxarthrosis	0.923	0.077	0.000
M20-M25 Other joint disorders	0.900	0.100	0.000
M15-M19 Arthrosis	0.886	0.114	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.867	0.133	0.000
M20.1 Hallux valgus (acquired)	0.853	0.147	0.000
M21 Other acquired deformities of limbs	0.852	0.148	0.000
K60.3 Anal fistula	0.830	0.170	0.000
M20.3 Other deformity of hallux (acquired)	0.823	0.177	0.000
M21.1 Varus deformity, not elsewhere classified	0.794	0.206	0.000
M18 Arthrosis of first carpometacarpal joint	0.774	0.226	0.000
M33 Dermatopolymyositis	0.773	0.227	0.000
M25 Other joint disorders, not elsewhere classified	0.763	0.237	0.000
M91-M94 Chondropathies	0.761	0.239	0.000
M20.0 Deformity of finger(s)	0.757	0.242	0.000
M25.8 Other specified joint disorders	0.754	0.246	0.000
K60.0 Acute anal fissure	0.731	0.269	0.000
M24 Other specific joint derangements	0.730	0.270	0.000
K60.4 Rectal fistula	0.718	0.281	0.000
M21.0 Valgus deformity, not elsewhere classified	0.717	0.283	0.000
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.716	0.284	0.000
M16.6 Other secondary coxarthrosis, bilateral	0.715	0.285	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.715	0.285	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.714	0.286	0.000
M86-M90 Other osteopathies	0.713	0.287	0.000
M25.86 Other specified joint disorders (Lower leg)	0.708	0.292	0.000
M16.7 Other secondary coxarthrosis	0.700	0.299	0.000
M16.5 Other posttraumatic coxarthrosis	0.700	0.300	0.000
M31 Other necrotising vasculopathies	0.696	0.304	0.000
M21.7 Unequal limb length (acquired)	0.686	0.314	0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.681	0.318	0.000
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.676	0.324	0.000
M33.1 Other dermatomyositis	0.672	0.328	0.000
M60-M63 Disorders of muscles	0.672	0.328	0.000
M25.4 Effusion of joint	0.671	0.329	0.000
M65-M68 Disorders of synovium and tendon	0.669	0.331	0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.658	0.342	0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.656	0.344	0.000
E20-E35 Disorders of other endocrine glands	0.656	0.344	0.000
M25.87 Other specified joint disorders (Ankle and foot)	0.653	0.347	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.645	0.354	0.000
M89 Other disorders of bone	0.644	0.356	0.000
E22 Hyperfunction of pituitary gland	0.640	0.360	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.640	0.360	0.000
M00-M03 Infectious arthropathies	0.635	0.365	0.000
E23 Hypofunction and other disorders of pituitary gland	0.635	0.365	0.000
M89.8 Other specified disorders of bone	0.633	0.367	0.000
E65-E68 Obesity and other hyperalimentation	0.628	0.372	0.000
M24.6 Ankylosis of joint	0.626	0.374	0.000
E66.8 Other obesity	0.624	0.376	0.000
E66 Obesity	0.624	0.376	0.000
M25.81 Other specified joint disorders (Shoulder region)	0.621	0.379	0.000
E24 Cushing's syndrome	0.620	0.380	0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.619	0.381	0.000
E23.0 Hypopituitarism	0.619	0.381	0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.618	0.382	0.000
M94 Other disorders of cartilage	0.617	0.383	0.000
M93 Other osteochondropathies	0.616	0.384	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.614	0.386	0.000
E00-E07 Disorders of thyroid gland	0.611	0.389	0.000
M21.9 Acquired deformity of limb, unspecified	0.611	0.389	0.000
M21.8 Other specified acquired deformities of limbs	0.611	0.389	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.607	0.393	0.000
M21.6 Other acquired deformities of ankle and foot	0.604	0.396	0.000
E03 Other hypothyroidism	0.602	0.398	0.000
E03.9 Hypothyroidism, unspecified	0.601	0.399	0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.600	0.400	0.000
H43 Disorders of vitreous body	0.600	0.400	0.000
E22.0 Acromegaly and pituitary gigantism	0.597	0.403	0.000
M67 Other disorders of synovium and tendon	0.596	0.404	0.000
H43.1 Vitreous haemorrhage	0.594	0.406	0.000
M20.4 Other hammer toe(s) (acquired)	0.590	0.410	0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.590	0.410	0.000
M92 Other juvenile osteochondrosis	0.589	0.411	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.588	0.412	0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.585	0.415	0.000
# Top node	0.584	0.416	0.000
M21.3 Wrist or foot drop (acquired)	0.583	0.417	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.582	0.418	0.000
M25.46 Effusion of joint (Lower leg)	0.582	0.418	0.000
S20-S29 Injuries to the thorax	0.581	0.419	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.579	0.421	0.000
H43-H45 Disorders of vitreous body and globe	0.578	0.422	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.578	0.422	0.000
M25.83 Other specified joint disorders (Forearm)	0.576	0.424	0.000
M33.2 Polymyositis	0.575	0.425	0.000
E06 Thyroiditis	0.575	0.425	0.000
M25.88 Other specified joint disorders (Other)	0.573	0.427	0.000
S22 Fracture of rib(s), sternum and thoracic spine	0.572	0.428	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.572	0.428	0.000
H43.8 Other disorders of vitreous body	0.570	0.430	0.000
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.569	0.430	0.000
M21.18 Varus deformity, not elsewhere classified (Other)	0.569	0.430	0.000
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.569	0.430	0.000
M21.14 Varus deformity, not elsewhere classified (Hand)	0.569	0.430	0.000
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.569	0.430	0.000
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.569	0.430	0.000
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.569	0.430	0.000
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.569	0.430	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.569	0.431	0.000
Chapter VII Diseases of the eye and adnexa	0.568	0.432	0.000
S22.3 Fracture of rib	0.567	0.433	0.000
M89.81 Other specified disorders of bone (Shoulder region)	0.567	0.433	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.566	0.434	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.566	0.434	0.000
S22.30 Fracture of rib (closed)	0.565	0.435	0.000
M22 Disorders of patella	0.563	0.437	0.000
L60 Nail disorders	0.563	0.437	0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.563	0.437	0.000
M32 Systemic lupus erythematosus	0.562	0.437	0.000
L60.0 Ingrowing nail	0.562	0.438	0.000
M87 Osteonecrosis	0.560	0.440	0.000
M67.1 Other contracture of tendon (sheath)	0.556	0.444	0.000
E24.9 Cushing's syndrome, unspecified	0.555	0.445	0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.555	0.445	0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.555	0.445	0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.555	0.445	0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.555	0.445	0.000
M33.9 Dermatopolymyositis, unspecified	0.554	0.446	0.000
M33.0 Juvenile dermatomyositis	0.554	0.446	0.000
M89.86 Other specified disorders of bone (Lower leg)	0.554	0.446	0.000
E23.2 Diabetes insipidus	0.554	0.446	0.000
Q24 Other congenital malformations of heart	0.553	0.447	0.000
M21.76 Unequal limb length (acquired) (Lower leg)	0.552	0.448	0.000
M25.40 Effusion of joint (Multiple sites)	0.552	0.448	0.000
L60-L75 Disorders of skin appendages	0.551	0.449	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.551	0.449	0.000
L20-L30 Dermatitis and eczema	0.551	0.449	0.000
M31.0 Hypersensitivity angiitis	0.550	0.450	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.549	0.451	0.000
H30-H36 Disorders of choroid and retina	0.549	0.451	0.000
M25.2 Flail joint	0.547	0.453	0.000
M25.1 Fistula of joint	0.547	0.453	0.000
M25.84 Other specified joint disorders (Hand)	0.546	0.454	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.545	0.455	0.000
H33 Retinal detachments and breaks	0.544	0.456	0.000
M31.3 Wegener's granulomatosis	0.544	0.456	0.000
S32 Fracture of lumbar spine and pelvis	0.543	0.457	0.000
E24.0 Pituitary-dependent Cushing's disease	0.542	0.458	0.000
E06.3 Autoimmune thyroiditis	0.542	0.458	0.000
M94.8 Other specified disorders of cartilage	0.542	0.458	0.000
M21.4 Flat foot [pes planus] (acquired)	0.541	0.459	0.000
K60.5 Anorectal fistula	0.541	0.459	0.000
M25.89 Other specified joint disorders (Site unspecified)	0.541	0.459	0.000
M25.82 Other specified joint disorders (Upper arm)	0.541	0.459	0.000
M25.80 Other specified joint disorders (Multiple sites)	0.541	0.459	0.000
E29 Testicular dysfunction	0.539	0.461	0.000
M60 Myositis	0.538	0.462	0.000
M24.67 Ankylosis of joint (Ankle and foot)	0.535	0.465	0.000
H33.0 Retinal detachment with retinal break	0.534	0.466	0.000
M66 Spontaneous rupture of synovium and tendon	0.534	0.466	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.532	0.468	0.000
S62.60 Fracture of other finger (closed)	0.532	0.468	0.000
M21.2 Flexion deformity	0.529	0.471	0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.528	0.472	0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.527	0.473	0.000
E26 Hyperaldosteronism	0.526	0.474	0.000
S32.0 Fracture of lumbar vertebra	0.525	0.475	0.000
S20 Superficial injury of thorax	0.524	0.476	0.000
M24.9 Joint derangement, unspecified	0.524	0.476	0.000
L27 Dermatitis due to substances taken internally	0.523	0.477	0.000
S62.6 Fracture of other finger	0.522	0.478	0.000
M89.88 Other specified disorders of bone (Other)	0.521	0.479	0.000
S60-S69 Injuries to the wrist and hand	0.521	0.479	0.000
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.520	0.480	0.000
Q24.8 Other specified congenital malformations of heart	0.518	0.482	0.000
E66.9 Obesity, unspecified	0.518	0.482	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.517	0.483	0.000
M30 Polyarteritis nodosa and related conditions	0.517	0.483	0.000
S62 Fracture at wrist and hand level	0.517	0.483	0.000
M24.0 Loose body in joint	0.517	0.483	0.000
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.514	0.486	0.000
M21.08 Valgus deformity, not elsewhere classified (Other)	0.514	0.486	0.000
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.514	0.486	0.000
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.514	0.486	0.000
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.514	0.486	0.000
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.514	0.486	0.000
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.514	0.486	0.000
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.514	0.486	0.000
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.513	0.486	0.000
S32.00 Fracture of lumbar vertebra (closed)	0.512	0.488	0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.512	0.488	0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.512	0.488	0.000
H43.3 Other vitreous opacities	0.512	0.488	0.000
M89.87 Other specified disorders of bone (Ankle and foot)	0.512	0.488	0.000
M93.9 Osteochondropathy, unspecified	0.511	0.489	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.510	0.490	0.000
M25.43 Effusion of joint (Forearm)	0.509	0.491	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.508	0.492	0.000
S70-S79 Injuries to the hip and thigh	0.508	0.492	0.000
S22.2 Fracture of sternum	0.507	0.493	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.507	0.493	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.507	0.493	0.000
M25.47 Effusion of joint (Ankle and foot)	0.503	0.497	0.000
Q60-Q64 Congenital malformations of the urinary system	0.503	0.497	0.000
M31.8 Other specified necrotising vasculopathies	0.499	0.501	0.000
M31.7 Microscopic polyangiitis	0.499	0.501	0.000
M31.4 Aortic arch syndrome [Takayasu]	0.499	0.501	0.000
M31.2 Lethal midline granuloma	0.499	0.501	0.000
M31.1 Thrombotic microangiopathy	0.499	0.501	0.000
M25.9 Joint disorder, unspecified	0.499	0.501	0.000
L60.8 Other nail disorders	0.498	0.502	0.000
L57 Skin changes due to chronic exposure to nonionising radiation	0.498	0.502	0.000
M89.85 Other specified disorders of bone (Pelvic region and thigh)	0.497	0.503	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.497	0.503	0.000
E22.1 Hyperprolactinaemia	0.497	0.503	0.000
M31.9 Necrotising vasculopathy, unspecified	0.497	0.503	0.000
M90 Osteopathies in diseases classified elsewhere	0.495	0.505	0.000
L29 Pruritus	0.494	0.506	0.000
E40-E46 Malnutrition	0.493	0.506	0.000
M21.79 Unequal limb length (acquired) (Site unspecified)	0.492	0.508	0.000
M21.78 Unequal limb length (acquired)-Other	0.492	0.508	0.000
M21.77 Unequal limb length (acquired) (Ankle and foot)	0.492	0.508	0.000
M21.74 Unequal limb length (acquired) (Hand)	0.492	0.508	0.000
M21.73 Unequal limb length (acquired) (Forearm)	0.492	0.508	0.000
M21.72 Unequal limb length (acquired) (Upper arm)	0.492	0.508	0.000
M21.71 Unequal limb length (acquired)-Shldr region	0.492	0.508	0.000
M21.70 Unequal limb length (acquired) (Multiple sites)	0.492	0.508	0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.490	0.510	0.000
M24.7 Protrusio acetabuli	0.490	0.510	0.000
Q27 Other congenital malformations of peripheral vascular system	0.488	0.512	0.000
H33.5 Other retinal detachments	0.488	0.512	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.487	0.513	0.000
M25.41 Effusion of joint (Shoulder region)	0.485	0.514	0.000
Q25 Congenital malformations of great arteries	0.484	0.515	0.000
H31 Other disorders of choroid	0.484	0.516	0.000
L27.1 Localised skin eruption due to drugs and medicaments	0.483	0.517	0.000
H43.2 Crystalline deposits in vitreous body	0.482	0.518	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.482	0.518	0.000
M61 Calcification and ossification of muscle	0.482	0.518	0.000
S72 Fracture of femur	0.481	0.519	0.000
M25.49 Effusion of joint (Site unspecified)	0.481	0.519	0.000
M25.48 Effusion of joint (Other)	0.481	0.519	0.000
M25.42 Effusion of joint (Upper arm)	0.481	0.519	0.000
Q24.9 Congenital malformation of the heart, unspecified	0.481	0.519	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.480	0.520	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.478	0.522	0.000
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.478	0.522	0.000
M62 Other disorders of muscle	0.474	0.526	0.000
M67.4 Ganglion	0.473	0.527	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.473	0.527	0.000
M21.59 Acquired clawhand, clubhand, clawfoot and clubfoot-Site uns	0.472	0.528	0.000
M21.58 Acquired clawhand, clubhand, clawfoot and clubfoot-Other	0.472	0.528	0.000
M21.56 Acquired clawhand, clubhand, clawfoot and clubfoot-Lower le	0.472	0.528	0.000
M21.55 Acquired clawhand, clubhand, clawfoot and clubfoot-Pelvic/t	0.472	0.528	0.000
M21.54 Acquired clawhand, clubhand, clawfoot and clubfoot (Hand)	0.472	0.528	0.000
M21.53 Acquired clawhand, clubhand, clawfoot and clubfoot-Forearm	0.472	0.528	0.000
M21.52 Acquired clawhand, clubhand, clawfoot and clubfoot-Upper ar	0.472	0.528	0.000
M21.51 Acquired clawhand, clubhand, clawfoot and clubfoot-Shldr re	0.472	0.528	0.000
M21.50 Acquired clawhand, clubhand, clawfoot and clubfoot (Multiple sites)	0.472	0.528	0.000
E20 Hypoparathyroidism	0.472	0.528	0.000
S21 Open wound of thorax	0.471	0.529	0.000
L57.0 Actinic keratosis	0.471	0.529	0.000
L29.0 Pruritus ani	0.471	0.529	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.470	0.530	0.000
E32 Diseases of thymus	0.470	0.530	0.000
E31 Polyglandular dysfunction	0.470	0.530	0.000
E30 Disorders of puberty, not elsewhere classified	0.470	0.530	0.000
E25 Adrenogenital disorders	0.470	0.530	0.000
M86 Osteomyelitis	0.469	0.531	0.000
S32.1 Fracture of sacrum	0.467	0.533	0.000
M87.9 Osteonecrosis, unspecified	0.466	0.534	0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand	0.466	0.534	0.000
E34 Other endocrine disorders	0.466	0.534	0.000
S30 Superficial injury of abdomen, lower back and pelvis	0.465	0.535	0.000
S36 Injury of intra-abdominal organs	0.464	0.536	0.000
M00 Pyogenic arthritis	0.463	0.536	0.000
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.463	0.537	0.000
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.463	0.537	0.000
M36.3 Arthropathy in other blood disorders	0.463	0.537	0.000
M36.2 Haemophilic arthropathy	0.463	0.537	0.000
M36.1 Arthropathy in neoplastic disease	0.463	0.537	0.000
M36.0 Dermato(poly)myositis in neoplastic disease	0.463	0.537	0.000
E24.2 Drug-induced Cushing's syndrome	0.463	0.537	0.000
M92.7 Juvenile osteochondrosis of metatarsus	0.462	0.538	0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.462	0.538	0.000
M89.6 Osteopathy after poliomyelitis	0.462	0.538	0.000
M89.4 Other hypertrophic osteo-arthropathy	0.462	0.538	0.000
M89.2 Other disorders of bone development and growth	0.462	0.538	0.000
M89.1 Epiphyseal arrest	0.462	0.538	0.000
Q63 Other congenital malformations of kidney	0.461	0.539	0.000
M89.84 Other specified disorders of bone (Hand)	0.461	0.539	0.000
M02 Reactive arthropathies	0.461	0.539	0.000
S22.20 Fracture of sternum (closed)	0.461	0.539	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.460	0.540	0.000
S65 Injury of blood vessels at wrist and hand level	0.460	0.540	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.459	0.541	0.000
E22.8 Other hyperfunction of pituitary gland	0.459	0.541	0.000
M94.85 Other specified disorders of cartilage (Pelvic region and thigh)	0.459	0.541	0.000
M25.0 Haemarthrosis	0.458	0.542	0.000
M94.88 Other specified disorders of cartilage (Other)	0.457	0.543	0.000
S29 Other and unspecified injuries of thorax	0.457	0.543	0.000
M15 Polyarthrosis	0.456	0.544	0.000
L23 Allergic contact dermatitis	0.456	0.544	0.000
M40-M43 Deforming dorsopathies	0.456	0.544	0.000
L27.0 Generalised skin eruption due to drugs and medicaments	0.456	0.544	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.455	0.544	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.455	0.544	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.455	0.545	0.000
E23.1 Drug-induced hypopituitarism	0.455	0.545	0.000
E29.1 Testicular hypofunction	0.455	0.545	0.000
M89.89 Other specified disorders of bone (Site unspecified)	0.454	0.546	0.000
M89.83 Other specified disorders of bone (Forearm)	0.454	0.546	0.000
M89.82 Other specified disorders of bone (Upper arm)	0.454	0.546	0.000
M89.80 Other specified disorders of bone (Multiple sites)	0.454	0.546	0.000
H43.9 Disorder of vitreous body, unspecified	0.453	0.547	0.000
S20.1 Other and unspecified superficial injuries of breast	0.451	0.549	0.000
M67.2 Synovial hypertrophy, not elsewhere classified	0.451	0.549	0.000
M25.44 Effusion of joint (Hand)	0.450	0.549	0.000
E67 Other hyperalimentation	0.450	0.550	0.000
E68 Sequelae of hyperalimentation	0.450	0.550	0.000
M94.9 Disorder of cartilage, unspecified	0.450	0.550	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.449	0.551	0.000
S31 Open wound of abdomen, lower back and pelvis	0.449	0.551	0.000
M24.69 Ankylosis of joint (Site unspecified)	0.448	0.551	0.000
M24.68 Ankylosis of joint (Other)	0.448	0.551	0.000
M24.66 Ankylosis of joint (Lower leg)	0.448	0.551	0.000
M24.64 Ankylosis of joint (Hand)	0.448	0.551	0.000
M24.63 Ankylosis of joint (Forearm)	0.448	0.551	0.000
M24.62 Ankylosis of joint (Upper arm)	0.448	0.551	0.000
M24.61 Ankylosis of joint (Shoulder region)	0.448	0.551	0.000
M24.60 Ankylosis of joint (Multiple sites)	0.448	0.551	0.000
M66.2 Spontaneous rupture of extensor tendons	0.448	0.552	0.000
E66.1 Drug-induced obesity	0.447	0.552	0.000
S22.4 Multiple fractures of ribs	0.447	0.552	0.000
M89.3 Hypertrophy of bone	0.447	0.553	0.000
E03.1 Congenital hypothyroidism without goitre	0.447	0.553	0.000
Q28 Other congenital malformations of circulatory system	0.447	0.553	0.000
E06.9 Thyroiditis, unspecified	0.445	0.555	0.000
E24.8 Other Cushing's syndrome	0.445	0.555	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.445	0.555	0.000
E24.3 Ectopic ACTH syndrome	0.445	0.555	0.000
E24.1 Nelson's syndrome	0.445	0.555	0.000
H30 Chorioretinal inflammation	0.445	0.555	0.000
L60.9 Nail disorder, unspecified	0.444	0.556	0.000
H33.1 Retinoschisis and retinal cysts	0.444	0.556	0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.443	0.557	0.000
T25 Burn and corrosion of ankle and foot	0.443	0.557	0.000
H33.2 Serous retinal detachment	0.443	0.557	0.000
M94.3 Chondrolysis	0.443	0.557	0.000
M94.1 Relapsing polychondritis	0.443	0.557	0.000
M94.0 Chondrocostal junction syndrome [Tietze]	0.443	0.557	0.000
S30.1 Contusion of abdominal wall	0.442	0.558	0.000
L68 Hypertrichosis	0.442	0.558	0.000
M93.8 Other specified osteochondropathies	0.441	0.558	0.000
M93.2 Osteochondritis dissecans	0.441	0.558	0.000
M93.1 Kienbock's disease of adults	0.441	0.558	0.000
M93.0 Slipped upper femoral epiphysis (nontraumatic)	0.441	0.558	0.000
S37 Injury of urinary and pelvic organs	0.441	0.559	0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.441	0.559	0.000
Q63.0 Accessory kidney	0.441	0.559	0.000
S62.4 Multiple fractures of metacarpal bones	0.440	0.560	0.000
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)	0.440	0.560	0.000
L60.3 Nail dystrophy	0.439	0.560	0.000
M89.5 Osteolysis	0.439	0.561	0.000
L60.1 Onycholysis	0.438	0.561	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.438	0.562	0.000
E00 Congenital iodine-deficiency syndrome	0.438	0.562	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.438	0.562	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.438	0.562	0.000
M21.89 Other specified acquired deformities of limbs (Site unspecified)	0.438	0.562	0.000
M21.88 Other specified acquired deformities of limbs-Other	0.438	0.562	0.000
M21.87 Other specified acquired deformities of limbs (Ankle and foot)	0.438	0.562	0.000
M21.86 Other specified acquired deformities of limbs (Lower leg)	0.438	0.562	0.000
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)	0.438	0.562	0.000
M21.84 Other specified acquired deformities of limbs (Hand)	0.438	0.562	0.000
M21.83 Other specified acquired deformities of limbs (Forearm)	0.438	0.562	0.000
M21.82 Other specified acquired deformities of limbs (Upper arm)	0.438	0.562	0.000
M21.81 Other specified acquired deformities of limbs (Shoulder region)	0.438	0.562	0.000
M21.80 Other specified acquired deformities of limbs (Multiple sites)	0.438	0.562	0.000
M21.99 Acquired deformity of limb, unspecified (Site unspecified)	0.438	0.562	0.000
M21.98 Acquired deformity of limb, unspecified-Other	0.438	0.562	0.000
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.438	0.562	0.000
M21.96 Acquired deformity of limb, unspecified (Lower leg)	0.438	0.562	0.000
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)	0.438	0.562	0.000
M21.94 Acquired deformity of limb, unspecified (Hand)	0.438	0.562	0.000
M21.93 Acquired deformity of limb, unspecified (Forearm)	0.438	0.562	0.000
M21.92 Acquired deformity of limb, unspecified (Upper arm)	0.438	0.562	0.000
M21.91 Acquired deformity of limb, unspecified (Shoulder region)	0.438	0.562	0.000
M21.90 Acquired deformity of limb, unspecified (Multiple sites)	0.438	0.562	0.000
M31.6 Other giant cell arteritis	0.437	0.563	0.000
Q22 Congenital malformations of pulmonary and tricuspid valves	0.437	0.563	0.000
M25.3 Other instability of joint	0.435	0.565	0.000
M35 Other systemic involvement of connective tissue	0.433	0.565	0.002
M24.01 Loose body in joint (Shoulder region)	0.435	0.565	0.000
Q38.7 Pharyngeal pouch	0.434	0.566	0.000
E26.0 Primary hyperaldosteronism	0.433	0.566	0.000
E27 Other disorders of adrenal gland	0.433	0.566	0.000
M21.69 Other acquired deformities of ankle and foot-Site unspec	0.433	0.567	0.000
M21.68 Other acquired deformities of ankle and foot-Other	0.433	0.567	0.000
M21.66 Other acquired deformities of ankle and foot-Lower leg	0.433	0.567	0.000
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh	0.433	0.567	0.000
M21.64 Other acquired deformities of ankle and foot-Hand	0.433	0.567	0.000
M21.63 Other acquired deformities of ankle and foot-Forearm	0.433	0.567	0.000
M21.62 Other acquired deformities of ankle and foot-Upper arm	0.433	0.567	0.000
M21.61 Other acquired deformities of ankle and foot-Shldr region	0.433	0.567	0.000
M21.60 Other acquired deformities of ankle and foot-Mult sites	0.433	0.567	0.000
E03.5 Myxoedema coma	0.432	0.568	0.000
E03.4 Atrophy of thyroid (acquired)	0.432	0.568	0.000
E03.3 Postinfectious hypothyroidism	0.432	0.568	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.432	0.568	0.000
H43.0 Vitreous prolapse	0.430	0.570	0.000
M22.3 Other derangements of patella	0.430	0.570	0.000
Q35-Q37 Cleft lip and cleft palate	0.428	0.572	0.000
T21 Burn and corrosion of trunk	0.428	0.572	0.000
M92.6 Juvenile osteochondrosis of tarsus	0.428	0.572	0.000
M67.9 Disorder of synovium and tendon, unspecified	0.428	0.572	0.000
M67.3 Transient synovitis	0.428	0.572	0.000
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.427	0.573	0.000
H49 Paralytic strabismus	0.427	0.573	0.000
Q24.5 Malformation of coronary vessels	0.426	0.574	0.000
M60.0 Infective myositis	0.425	0.575	0.000
E07 Other disorders of thyroid	0.424	0.576	0.000
S64 Injury of nerves at wrist and hand level	0.423	0.577	0.000
M92.5 Juvenile osteochondrosis of tibia and fibula	0.423	0.577	0.000
M92.1 Juvenile osteochondrosis of radius and ulna	0.423	0.577	0.000
M92.9 Juvenile osteochondrosis, unspecified	0.423	0.577	0.000
M92.8 Other specified juvenile osteochondrosis	0.423	0.577	0.000
M92.4 Juvenile osteochondrosis of patella	0.423	0.577	0.000
M92.3 Other juvenile osteochondrosis of upper limb	0.423	0.577	0.000
M92.2 Juvenile osteochondrosis of hand	0.423	0.577	0.000
M92.0 Juvenile osteochondrosis of humerus	0.423	0.577	0.000
T31 Burns classified according to extent of body surface involved	0.422	0.578	0.000
H31.8 Other specified disorders of choroid	0.422	0.578	0.000
T23 Burn and corrosion of wrist and hand	0.422	0.578	0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.421	0.578	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.421	0.578	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.421	0.578	0.000
S72.1 Pertrochanteric fracture	0.421	0.579	0.000
S72.9 Fracture of femur, part unspecified	0.420	0.579	0.000
L10-L14 Bullous disorders	0.419	0.581	0.000
M22.2 Patellofemoral disorders	0.419	0.581	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.419	0.581	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.419	0.581	0.000
Q00-Q07 Congenital malformations of the nervous system	0.418	0.581	0.000
M21.39 Wrist or foot drop (acquired)-Site unspec	0.418	0.582	0.000
M21.38 Wrist or foot drop (acquired)-Other	0.418	0.582	0.000
M21.36 Wrist or foot drop (acquired)-Lower leg	0.418	0.582	0.000
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.418	0.582	0.000
M21.34 Wrist or foot drop (acquired) (Hand)	0.418	0.582	0.000
M21.33 Wrist or foot drop (acquired) (Forearm)	0.418	0.582	0.000
M21.32 Wrist or foot drop (acquired)-Upper arm	0.418	0.582	0.000
M21.31 Wrist or foot drop (acquired)-Shldr region	0.418	0.582	0.000
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.418	0.582	0.000
E66.0 Obesity due to excess calories	0.417	0.583	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.417	0.583	0.000
S27 Injury of other and unspecified intrathoracic organs	0.417	0.583	0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax	0.416	0.583	0.000
S26 Injury of heart	0.416	0.583	0.000
S25 Injury of blood vessels of thorax	0.416	0.583	0.000
S24 Injury of nerves and spinal cord at thorax level	0.416	0.583	0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax	0.416	0.583	0.000
M87.8 Other osteonecrosis	0.416	0.584	0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere	0.414	0.585	0.000
T33-T35 Frostbite	0.414	0.586	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.414	0.586	0.000
M22.0 Recurrent dislocation of patella	0.412	0.588	0.000
E06.5 Other chronic thyroiditis	0.412	0.588	0.000
E06.4 Drug-induced thyroiditis	0.412	0.588	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.412	0.588	0.000
E06.1 Subacute thyroiditis	0.412	0.588	0.000
E06.0 Acute thyroiditis	0.412	0.588	0.000
S32.10 Fracture of sacrum (closed)	0.412	0.588	0.000
T09 Other injuries of spine and trunk, level unspecified	0.411	0.589	0.000
S22.9 Fracture of bony thorax, part unspecified	0.410	0.590	0.000
S22.8 Fracture of other parts of bony thorax	0.410	0.590	0.000
Q26 Congenital malformations of great veins	0.410	0.590	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.410	0.590	0.000
T22.3 Burn of third degree of shoulder and upper limb, except wrist and hand	0.410	0.590	0.000
L63 Alopecia areata	0.409	0.590	0.000
M60.9 Myositis, unspecified	0.408	0.592	0.000
M25.45 Effusion of joint (Pelvic region and thigh)	0.408	0.592	0.000
S72.2 Subtrochanteric fracture	0.408	0.592	0.000
S22.31 Fracture of rib (open)	0.407	0.593	0.000
L21 Seborrhoeic dermatitis	0.406	0.594	0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis	0.406	0.594	0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level	0.406	0.594	0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level	0.406	0.594	0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis	0.406	0.594	0.000
M89.0 Algoneurodystrophy	0.406	0.594	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.405	0.595	0.000
Q78 Other osteochondrodysplasias	0.404	0.596	0.000
M22.1 Recurrent subluxation of patella	0.404	0.596	0.000
L60.5 Yellow nail syndrome	0.404	0.596	0.000
L60.4 Beau's lines	0.404	0.596	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.403	0.596	0.000
M32.8 Other forms of systemic lupus erythematosus	0.403	0.596	0.000
M32.0 Drug-induced systemic lupus erythematosus	0.403	0.596	0.000
E23.6 Other disorders of pituitary gland	0.403	0.596	0.000
M87.3 Other secondary osteonecrosis	0.402	0.598	0.000
M87.1 Osteonecrosis due to drugs	0.402	0.598	0.000
M87.0 Idiopathic aseptic necrosis of bone	0.402	0.598	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations