TreeWAS – Variant ID: rs17649553

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M16.9 Coxarthrosis, unspecified	1.000	0.000	0.000
M16 Coxarthrosis [arthrosis of hip]	1.000	0.000	0.000
M16.1 Other primary coxarthrosis	0.999	0.001	0.000
M20 Acquired deformities of fingers and toes	0.995	0.005	0.000
M20.2 Hallux rigidus	0.990	0.010	0.000
M20.5 Other deformities of toe(s) (acquired)	0.989	0.011	0.000
M15-M19 Arthrosis	0.984	0.016	0.000
K60.2 Anal fissure, unspecified	0.978	0.022	0.000
M18 Arthrosis of first carpometacarpal joint	0.974	0.026	0.000
M20.1 Hallux valgus (acquired)	0.969	0.031	0.000
K60 Fissure and fistula of anal and rectal regions	0.959	0.041	0.000
K60.1 Chronic anal fissure	0.958	0.042	0.000
M20.3 Other deformity of hallux (acquired)	0.948	0.052	0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.938	0.062	0.000
M20-M25 Other joint disorders	0.925	0.075	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.919	0.081	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.883	0.117	0.000
M16.3 Other dysplastic coxarthrosis	0.882	0.118	0.000
E66.8 Other obesity	0.880	0.120	0.000
E66 Obesity	0.877	0.123	0.000
E66.9 Obesity, unspecified	0.873	0.127	0.000
M31 Other necrotising vasculopathies	0.866	0.134	0.000
M20.0 Deformity of finger(s)	0.864	0.136	0.000
M91-M94 Chondropathies	0.810	0.190	0.000
M21 Other acquired deformities of limbs	0.805	0.195	0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.796	0.204	0.000
M16.7 Other secondary coxarthrosis	0.783	0.217	0.000
E65-E68 Obesity and other hyperalimentation	0.766	0.234	0.000
M65-M68 Disorders of synovium and tendon	0.762	0.238	0.000
M86-M90 Other osteopathies	0.759	0.241	0.000
M31.3 Wegener's granulomatosis	0.756	0.244	0.000
M33 Dermatopolymyositis	0.751	0.249	0.000
M21.1 Varus deformity, not elsewhere classified	0.732	0.268	0.000
K60.3 Anal fistula	0.723	0.277	0.000
E20-E35 Disorders of other endocrine glands	0.719	0.281	0.000
M94 Other disorders of cartilage	0.719	0.281	0.000
M31.6 Other giant cell arteritis	0.717	0.283	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.717	0.283	0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.713	0.287	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.712	0.288	0.000
M60-M63 Disorders of muscles	0.709	0.291	0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.698	0.302	0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.698	0.302	0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.698	0.302	0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.698	0.302	0.000
M19 Other arthrosis	0.697	0.303	0.000
E22 Hyperfunction of pituitary gland	0.693	0.307	0.000
M67 Other disorders of synovium and tendon	0.691	0.309	0.000
K60.4 Rectal fistula	0.687	0.313	0.000
E24 Cushing's syndrome	0.682	0.318	0.000
M00-M03 Infectious arthropathies	0.681	0.319	0.000
M31.0 Hypersensitivity angiitis	0.676	0.324	0.000
M21.0 Valgus deformity, not elsewhere classified	0.669	0.331	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.663	0.337	0.000
M89 Other disorders of bone	0.663	0.337	0.000
E26 Hyperaldosteronism	0.662	0.337	0.000
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.660	0.340	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.658	0.342	0.000
M94.8 Other specified disorders of cartilage	0.656	0.344	0.000
E23 Hypofunction and other disorders of pituitary gland	0.655	0.345	0.000
M67.1 Other contracture of tendon (sheath)	0.653	0.347	0.000
E22.0 Acromegaly and pituitary gigantism	0.653	0.347	0.000
M19.0 Primary arthrosis of other joints	0.652	0.348	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.650	0.350	0.000
M16.6 Other secondary coxarthrosis, bilateral	0.649	0.351	0.000
M25 Other joint disorders, not elsewhere classified	0.649	0.351	0.000
M89.8 Other specified disorders of bone	0.647	0.353	0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.646	0.354	0.000
M33.1 Other dermatomyositis	0.642	0.358	0.000
M87 Osteonecrosis	0.640	0.360	0.000
E00-E07 Disorders of thyroid gland	0.639	0.361	0.000
M25.8 Other specified joint disorders	0.632	0.368	0.000
M66 Spontaneous rupture of synovium and tendon	0.630	0.370	0.000
M20.4 Other hammer toe(s) (acquired)	0.630	0.370	0.000
M31.9 Necrotising vasculopathy, unspecified	0.629	0.371	0.000
E66.1 Drug-induced obesity	0.629	0.371	0.000
M31.8 Other specified necrotising vasculopathies	0.621	0.379	0.000
M31.7 Microscopic polyangiitis	0.621	0.379	0.000
M31.4 Aortic arch syndrome [Takayasu]	0.621	0.379	0.000
M31.2 Lethal midline granuloma	0.621	0.379	0.000
M31.1 Thrombotic microangiopathy	0.621	0.379	0.000
E26.0 Primary hyperaldosteronism	0.617	0.383	0.000
M21.7 Unequal limb length (acquired)	0.617	0.383	0.000
E23.0 Hypopituitarism	0.615	0.385	0.000
E66.0 Obesity due to excess calories	0.613	0.387	0.000
M16.5 Other posttraumatic coxarthrosis	0.612	0.388	0.000
E24.9 Cushing's syndrome, unspecified	0.612	0.388	0.000
K60.0 Acute anal fissure	0.610	0.390	0.000
M92 Other juvenile osteochondrosis	0.608	0.392	0.000
E06 Thyroiditis	0.605	0.395	0.000
E34 Other endocrine disorders	0.600	0.400	0.000
E24.0 Pituitary-dependent Cushing's disease	0.598	0.402	0.000
M94.88 Other specified disorders of cartilage (Other)	0.595	0.405	0.000
M93 Other osteochondropathies	0.595	0.405	0.000
M89.86 Other specified disorders of bone (Lower leg)	0.593	0.407	0.000
M89.81 Other specified disorders of bone (Shoulder region)	0.590	0.410	0.000
M60 Myositis	0.588	0.411	0.000
E29 Testicular dysfunction	0.588	0.412	0.000
M25.86 Other specified joint disorders (Lower leg)	0.585	0.415	0.000
M25.4 Effusion of joint	0.582	0.418	0.000
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.580	0.420	0.000
M21.3 Wrist or foot drop (acquired)	0.578	0.422	0.000
M21.9 Acquired deformity of limb, unspecified	0.577	0.423	0.000
M21.8 Other specified acquired deformities of limbs	0.577	0.423	0.000
M25.87 Other specified joint disorders (Ankle and foot)	0.575	0.425	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.000	0.428	0.572
E66.2 Extreme obesity with alveolar hypoventilation	0.572	0.428	0.000
E22.1 Hyperprolactinaemia	0.572	0.428	0.000
E06.3 Autoimmune thyroiditis	0.572	0.428	0.000
M32 Systemic lupus erythematosus	0.571	0.428	0.000
E03 Other hypothyroidism	0.571	0.429	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.569	0.431	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.000	0.431	0.569
M21.6 Other acquired deformities of ankle and foot	0.568	0.431	0.000
M24 Other specific joint derangements	0.563	0.437	0.000
M94.85 Other specified disorders of cartilage (Pelvic region and thigh)	0.562	0.438	0.000
M67.4 Ganglion	0.562	0.438	0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type	0.000	0.439	0.561
M87.9 Osteonecrosis, unspecified	0.557	0.443	0.000
M94.0 Chondrocostal junction syndrome [Tietze]	0.554	0.446	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.552	0.448	0.000
E23.2 Diabetes insipidus	0.551	0.449	0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.000	0.450	0.550
E67 Other hyperalimentation	0.549	0.451	0.000
E68 Sequelae of hyperalimentation	0.549	0.451	0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.548	0.452	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.547	0.453	0.000
M67.2 Synovial hypertrophy, not elsewhere classified	0.544	0.456	0.000
M90 Osteopathies in diseases classified elsewhere	0.543	0.457	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.543	0.457	0.000
M94.9 Disorder of cartilage, unspecified	0.542	0.458	0.000
E03.9 Hypothyroidism, unspecified	0.541	0.459	0.000
E07 Other disorders of thyroid	0.541	0.459	0.000
M33.9 Dermatopolymyositis, unspecified	0.538	0.461	0.000
M33.0 Juvenile dermatomyositis	0.538	0.461	0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.538	0.462	0.000
M66.2 Spontaneous rupture of extensor tendons	0.531	0.469	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.000	0.471	0.529
E20 Hypoparathyroidism	0.527	0.473	0.000
M19.08 Primary arthrosis of other joints (Other)	0.526	0.474	0.000
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.525	0.475	0.000
M21.18 Varus deformity, not elsewhere classified (Other)	0.525	0.475	0.000
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.525	0.475	0.000
M21.14 Varus deformity, not elsewhere classified (Hand)	0.525	0.475	0.000
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.525	0.475	0.000
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.525	0.475	0.000
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.525	0.475	0.000
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.525	0.475	0.000
M19.00 Primary arthrosis of other joints (Multiple sites)	0.524	0.475	0.000
C85.1 B-cell lymphoma, unspecified	0.000	0.476	0.524
C88 Malignant immunoproliferative diseases	0.000	0.480	0.520
M30 Polyarteritis nodosa and related conditions	0.520	0.480	0.000
M22 Disorders of patella	0.519	0.480	0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.516	0.484	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.516	0.484	0.000
E32 Diseases of thymus	0.516	0.484	0.000
E31 Polyglandular dysfunction	0.516	0.484	0.000
E30 Disorders of puberty, not elsewhere classified	0.516	0.484	0.000
E25 Adrenogenital disorders	0.516	0.484	0.000
M94.3 Chondrolysis	0.516	0.484	0.000
M94.1 Relapsing polychondritis	0.516	0.484	0.000
C84 Peripheral and cutaneous T-cell lymphomas	0.000	0.485	0.515
M02 Reactive arthropathies	0.513	0.487	0.000
E40-E46 Malnutrition	0.511	0.489	0.000
E24.2 Drug-induced Cushing's syndrome	0.510	0.490	0.000
M89.85 Other specified disorders of bone (Pelvic region and thigh)	0.510	0.490	0.000
C83.3 Large cell (diffuse)	0.000	0.491	0.509
M63 Disorders of muscle in diseases classified elsewhere	0.508	0.492	0.000
M61 Calcification and ossification of muscle	0.508	0.492	0.000
M33.2 Polymyositis	0.507	0.493	0.000
M25.43 Effusion of joint (Forearm)	0.503	0.497	0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.503	0.497	0.000
E34.0 Carcinoid syndrome	0.502	0.498	0.000
M25.81 Other specified joint disorders (Shoulder region)	0.501	0.499	0.000
M19.8 Other specified arthrosis	0.500	0.500	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.497	0.503	0.000
E22.8 Other hyperfunction of pituitary gland	0.497	0.503	0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.497	0.503	0.000
M25.40 Effusion of joint (Multiple sites)	0.497	0.503	0.000
M67.9 Disorder of synovium and tendon, unspecified	0.496	0.504	0.000
M67.3 Transient synovitis	0.496	0.504	0.000
M21.4 Flat foot [pes planus] (acquired)	0.495	0.504	0.000
M66.3 Spontaneous rupture of flexor tendons	0.495	0.505	0.000
E26.9 Hyperaldosteronism, unspecified	0.495	0.505	0.000
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)	0.494	0.506	0.000
M87.1 Osteonecrosis due to drugs	0.494	0.506	0.000
E29.1 Testicular hypofunction	0.494	0.506	0.000
M92.7 Juvenile osteochondrosis of metatarsus	0.490	0.510	0.000
E24.8 Other Cushing's syndrome	0.489	0.511	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.489	0.511	0.000
E24.3 Ectopic ACTH syndrome	0.489	0.511	0.000
E24.1 Nelson's syndrome	0.489	0.511	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.489	0.511	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.488	0.512	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.488	0.512	0.000
E34.3 Short stature, not elsewhere classified	0.488	0.512	0.000
M80-M85 Disorders of bone density and structure	0.487	0.513	0.000
M89.88 Other specified disorders of bone (Other)	0.485	0.514	0.000
M00 Pyogenic arthritis	0.485	0.515	0.000
E06.9 Thyroiditis, unspecified	0.485	0.515	0.000
C82.1 Mixed small cleaved and large cell, follicular	0.000	0.517	0.483
M67.0 Short Achilles tendon (acquired)	0.482	0.517	0.000
M60.0 Infective myositis	0.481	0.519	0.000
E07.9 Disorder of thyroid, unspecified	0.481	0.519	0.000
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.480	0.520	0.000
M21.08 Valgus deformity, not elsewhere classified (Other)	0.480	0.520	0.000
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.480	0.520	0.000
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.480	0.520	0.000
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.480	0.520	0.000
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.480	0.520	0.000
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.480	0.520	0.000
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.480	0.520	0.000
M21.2 Flexion deformity	0.479	0.521	0.000
M25.46 Effusion of joint (Lower leg)	0.478	0.522	0.000
C88.0 Waldenstrom's macroglobulinaemia	0.000	0.522	0.478
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.475	0.524	0.000
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.475	0.524	0.000
M36.3 Arthropathy in other blood disorders	0.475	0.524	0.000
M36.2 Haemophilic arthropathy	0.475	0.524	0.000
M36.1 Arthropathy in neoplastic disease	0.475	0.524	0.000
M36.0 Dermato(poly)myositis in neoplastic disease	0.475	0.524	0.000
M89.6 Osteopathy after poliomyelitis	0.475	0.524	0.000
M89.4 Other hypertrophic osteo-arthropathy	0.475	0.524	0.000
M89.2 Other disorders of bone development and growth	0.475	0.524	0.000
M89.1 Epiphyseal arrest	0.475	0.524	0.000
E26.8 Other hyperaldosteronism	0.475	0.525	0.000
E26.1 Secondary hyperaldosteronism	0.475	0.525	0.000
M19.1 Posttraumatic arthrosis of other joints	0.473	0.527	0.000
M94.87 Other specified disorders of cartilage (Ankle and foot)	0.471	0.529	0.000
M94.84 Other specified disorders of cartilage (Hand)	0.471	0.529	0.000
M94.83 Other specified disorders of cartilage (Forearm)	0.471	0.529	0.000
M94.82 Other specified disorders of cartilage (Upper arm)	0.471	0.529	0.000
M94.81 Other specified disorders of cartilage (Shoulder region)	0.471	0.529	0.000
M94.80 Other specified disorders of cartilage (Multiple sites)	0.471	0.529	0.000
M87.8 Other osteonecrosis	0.471	0.529	0.000
M19.2 Other secondary arthrosis	0.470	0.529	0.000
M21.76 Unequal limb length (acquired) (Lower leg)	0.470	0.530	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.470	0.530	0.000
E23.1 Drug-induced hypopituitarism	0.470	0.530	0.000
M89.3 Hypertrophy of bone	0.470	0.530	0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.469	0.531	0.000
E50-E64 Other nutritional deficiencies	0.468	0.532	0.000
C90 Multiple myeloma and malignant plasma cell neoplasms	0.000	0.532	0.468
M19.09 Primary arthrosis of other joints (Site unspecified)	0.468	0.532	0.000
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)	0.468	0.532	0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified	0.000	0.533	0.467
M25.2 Flail joint	0.465	0.535	0.000
M25.1 Fistula of joint	0.465	0.535	0.000
M99 Biomechanical lesions, not elsewhere classified	0.465	0.535	0.000
M89.89 Other specified disorders of bone (Site unspecified)	0.464	0.536	0.000
M89.83 Other specified disorders of bone (Forearm)	0.464	0.536	0.000
M89.82 Other specified disorders of bone (Upper arm)	0.464	0.536	0.000
M89.80 Other specified disorders of bone (Multiple sites)	0.464	0.536	0.000
C82.2 Large cell, follicular	0.000	0.537	0.463
M89.87 Other specified disorders of bone (Ankle and foot)	0.460	0.540	0.000
M86 Osteomyelitis	0.460	0.540	0.000
M94.89 Other specified disorders of cartilage (Site unspecified)	0.460	0.540	0.000
M66.24 Spontaneous rupture of extensor tendons (Hand)	0.460	0.540	0.000
M89.84 Other specified disorders of bone (Hand)	0.460	0.540	0.000
M66.0 Rupture of popliteal cyst	0.460	0.540	0.000
M87.3 Other secondary osteonecrosis	0.459	0.541	0.000
M87.0 Idiopathic aseptic necrosis of bone	0.459	0.541	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.458	0.542	0.000
E00 Congenital iodine-deficiency syndrome	0.458	0.542	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.458	0.542	0.000
M62 Other disorders of muscle	0.458	0.542	0.000
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.456	0.544	0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified	0.455	0.545	0.000
M25.88 Other specified joint disorders (Other)	0.454	0.546	0.000
C91 Lymphoid leukaemia	0.000	0.547	0.453
M25.89 Other specified joint disorders (Site unspecified)	0.453	0.547	0.000
M25.82 Other specified joint disorders (Upper arm)	0.453	0.547	0.000
M25.80 Other specified joint disorders (Multiple sites)	0.453	0.547	0.000
M25.3 Other instability of joint	0.453	0.547	0.000
M66.5 Spontaneous rupture of unspecified tendon	0.452	0.548	0.000
M66.1 Rupture of synovium	0.452	0.548	0.000
C84.4 Peripheral T-cell lymphoma	0.000	0.549	0.451
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.451	0.549	0.000
M67.43 Ganglion, wrist	0.448	0.552	0.000
M25.83 Other specified joint disorders (Forearm)	0.446	0.554	0.000
E65 Localised adiposity	0.445	0.555	0.000
C93 Monocytic leukaemia	0.000	0.556	0.444
M21.79 Unequal limb length (acquired) (Site unspecified)	0.442	0.558	0.000
M21.78 Unequal limb length (acquired)-Other	0.442	0.558	0.000
M21.77 Unequal limb length (acquired) (Ankle and foot)	0.442	0.558	0.000
M21.74 Unequal limb length (acquired) (Hand)	0.442	0.558	0.000
M21.73 Unequal limb length (acquired) (Forearm)	0.442	0.558	0.000
M21.72 Unequal limb length (acquired) (Upper arm)	0.442	0.558	0.000
M21.71 Unequal limb length (acquired)-Shldr region	0.442	0.558	0.000
M21.70 Unequal limb length (acquired) (Multiple sites)	0.442	0.558	0.000
M93.9 Osteochondropathy, unspecified	0.441	0.558	0.000
C82.0 Small cleaved cell, follicular	0.000	0.560	0.440
E34.9 Endocrine disorder, unspecified	0.438	0.562	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.437	0.563	0.000
M92.5 Juvenile osteochondrosis of tibia and fibula	0.436	0.564	0.000
M92.1 Juvenile osteochondrosis of radius and ulna	0.436	0.564	0.000
M92.9 Juvenile osteochondrosis, unspecified	0.436	0.564	0.000
M92.8 Other specified juvenile osteochondrosis	0.436	0.564	0.000
M92.4 Juvenile osteochondrosis of patella	0.436	0.564	0.000
M92.3 Other juvenile osteochondrosis of upper limb	0.436	0.564	0.000
M92.2 Juvenile osteochondrosis of hand	0.436	0.564	0.000
M92.0 Juvenile osteochondrosis of humerus	0.436	0.564	0.000
E06.5 Other chronic thyroiditis	0.434	0.566	0.000
E06.4 Drug-induced thyroiditis	0.434	0.566	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.434	0.566	0.000
E06.1 Subacute thyroiditis	0.434	0.566	0.000
E06.0 Acute thyroiditis	0.434	0.566	0.000
M24.6 Ankylosis of joint	0.434	0.566	0.000
M88 Paget's disease of bone [osteitis deformans]	0.432	0.567	0.001
M67.47 Ganglion, ankle and foot	0.432	0.567	0.000
M89.5 Osteolysis	0.432	0.568	0.000
C84.5 Other and unspecified T-cell lymphomas	0.000	0.568	0.432
M19.03 Primary arthrosis of other joints (Forearm)	0.431	0.569	0.000
E34.5 Androgen resistance syndrome	0.431	0.569	0.000
E34.4 Constitutional tall stature	0.431	0.569	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.431	0.569	0.000
E34.1 Other hypersecretion of intestinal hormones	0.431	0.569	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.431	0.569	0.000
K60.5 Anorectal fistula	0.430	0.569	0.001
M93.8 Other specified osteochondropathies	0.427	0.573	0.000
M93.2 Osteochondritis dissecans	0.427	0.573	0.000
M93.1 Kienbock's disease of adults	0.427	0.573	0.000
M93.0 Slipped upper femoral epiphysis (nontraumatic)	0.427	0.573	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.427	0.573	0.000
M85 Other disorders of bone density and structure	0.426	0.574	0.000
M19.17 Post-traumatic arthrosis of other joints (Ankle and foot)	0.426	0.574	0.000
M25.47 Effusion of joint (Ankle and foot)	0.425	0.575	0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma	0.000	0.576	0.424
M94.2 Chondromalacia	0.422	0.577	0.000
M60.8 Other myositis	0.422	0.578	0.000
M60.1 Interstitial myositis	0.422	0.578	0.000
M60.9 Myositis, unspecified	0.422	0.578	0.000
E29.9 Testicular dysfunction, unspecified	0.421	0.578	0.000
E29.8 Other testicular dysfunction	0.421	0.578	0.000
E29.0 Testicular hyperfunction	0.421	0.578	0.000
C95 Leukaemia of unspecified cell type	0.000	0.582	0.418
M94.08 Chondrocostal junction syndrome [Tietze]-Other	0.418	0.582	0.000
M25.49 Effusion of joint (Site unspecified)	0.418	0.582	0.000
M25.48 Effusion of joint (Other)	0.418	0.582	0.000
M94.09 Chondrocostal junction syndrome [Tietze]-Site unspec	0.417	0.583	0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.416	0.584	0.000
M87.96 Osteonecrosis, unspecified (Lower leg)	0.416	0.584	0.000
M94.96 Disorder of cartilage, unspecified (Lower leg)	0.415	0.585	0.000
M21.39 Wrist or foot drop (acquired)-Site unspec	0.415	0.585	0.000
M21.38 Wrist or foot drop (acquired)-Other	0.415	0.585	0.000
M21.36 Wrist or foot drop (acquired)-Lower leg	0.415	0.585	0.000
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.415	0.585	0.000
M21.34 Wrist or foot drop (acquired) (Hand)	0.415	0.585	0.000
M21.33 Wrist or foot drop (acquired) (Forearm)	0.415	0.585	0.000
M21.32 Wrist or foot drop (acquired)-Upper arm	0.415	0.585	0.000
M21.31 Wrist or foot drop (acquired)-Shldr region	0.415	0.585	0.000
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.415	0.585	0.000
M21.89 Other specified acquired deformities of limbs (Site unspecified)	0.414	0.586	0.000
M21.88 Other specified acquired deformities of limbs-Other	0.414	0.586	0.000
M21.87 Other specified acquired deformities of limbs (Ankle and foot)	0.414	0.586	0.000
M21.86 Other specified acquired deformities of limbs (Lower leg)	0.414	0.586	0.000
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)	0.414	0.586	0.000
M21.84 Other specified acquired deformities of limbs (Hand)	0.414	0.586	0.000
M21.83 Other specified acquired deformities of limbs (Forearm)	0.414	0.586	0.000
M21.82 Other specified acquired deformities of limbs (Upper arm)	0.414	0.586	0.000
M21.81 Other specified acquired deformities of limbs (Shoulder region)	0.414	0.586	0.000
M21.80 Other specified acquired deformities of limbs (Multiple sites)	0.414	0.586	0.000
M21.99 Acquired deformity of limb, unspecified (Site unspecified)	0.414	0.586	0.000
M21.98 Acquired deformity of limb, unspecified-Other	0.414	0.586	0.000
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.414	0.586	0.000
M21.96 Acquired deformity of limb, unspecified (Lower leg)	0.414	0.586	0.000
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)	0.414	0.586	0.000
M21.94 Acquired deformity of limb, unspecified (Hand)	0.414	0.586	0.000
M21.93 Acquired deformity of limb, unspecified (Forearm)	0.414	0.586	0.000
M21.92 Acquired deformity of limb, unspecified (Upper arm)	0.414	0.586	0.000
M21.91 Acquired deformity of limb, unspecified (Shoulder region)	0.414	0.586	0.000
M21.90 Acquired deformity of limb, unspecified (Multiple sites)	0.414	0.586	0.000
C81 Hodgkin's disease	0.000	0.586	0.414
M90.7 Fracture of bone in neoplastic disease	0.413	0.587	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.412	0.587	0.000
E61 Deficiency of other nutrient elements	0.412	0.588	0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.000	0.589	0.410
C94 Other leukaemias of specified cell type	0.000	0.589	0.410
C86 Other specified types of T/NK-cell lymphoma	0.000	0.589	0.410
M25.84 Other specified joint disorders (Hand)	0.410	0.589	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.410	0.590	0.000
M32.8 Other forms of systemic lupus erythematosus	0.410	0.590	0.000
M32.0 Drug-induced systemic lupus erythematosus	0.410	0.590	0.000
E03.5 Myxoedema coma	0.410	0.590	0.000
E03.4 Atrophy of thyroid (acquired)	0.410	0.590	0.000
E03.3 Postinfectious hypothyroidism	0.410	0.590	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.410	0.590	0.000
C90.0 Multiple myeloma	0.000	0.591	0.409
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.409	0.591	0.000
M15 Polyarthrosis	0.408	0.591	0.001
M91.9 Juvenile osteochondrosis of hip and pelvis, unspecified	0.408	0.592	0.000
M91.8 Other juvenile osteochondrosis of hip and pelvis	0.408	0.592	0.000
M91.3 Pseudocoxalgia	0.408	0.592	0.000
M91.1 Juvenile osteochondrosis of head of femur [Legg-Calve-Perthes]	0.408	0.592	0.000
M91.0 Juvenile osteochondrosis of pelvis	0.408	0.592	0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma	0.000	0.592	0.408
C85.0 Lymphosarcoma	0.000	0.592	0.408
M21.69 Other acquired deformities of ankle and foot-Site unspec	0.408	0.592	0.000
M21.68 Other acquired deformities of ankle and foot-Other	0.408	0.592	0.000
M21.66 Other acquired deformities of ankle and foot-Lower leg	0.408	0.592	0.000
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh	0.408	0.592	0.000
M21.64 Other acquired deformities of ankle and foot-Hand	0.408	0.592	0.000
M21.63 Other acquired deformities of ankle and foot-Forearm	0.408	0.592	0.000
M21.62 Other acquired deformities of ankle and foot-Upper arm	0.408	0.592	0.000
M21.61 Other acquired deformities of ankle and foot-Shldr region	0.408	0.592	0.000
M21.60 Other acquired deformities of ankle and foot-Mult sites	0.408	0.592	0.000
E03.1 Congenital hypothyroidism without goitre	0.406	0.594	0.000
M19.04 Primary arthrosis of other joints (Hand)	0.406	0.594	0.000
M24.9 Joint derangement, unspecified	0.404	0.596	0.000
M67.49 Ganglion, multiple sites	0.403	0.597	0.000
M67.45 Ganglion, hip	0.403	0.597	0.000
M20.6 Acquired deformity of toe(s), unspecified	0.402	0.598	0.000
M17 Gonarthrosis [arthrosis of knee]	0.402	0.598	0.000
C83.7 Burkitt's tumour	0.000	0.598	0.402
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.402	0.598	0.000
M87.97 Osteonecrosis, unspecified (Ankle and foot)	0.401	0.599	0.000
M94.86 Other specified disorders of cartilage (Lower leg)	0.401	0.599	0.000
M87.99 Osteonecrosis, unspecified (Site unspecified)	0.399	0.601	0.000
M87.98 Osteonecrosis, unspecified (Other)	0.399	0.601	0.000
M87.94 Osteonecrosis, unspecified (Hand)	0.399	0.601	0.000
M87.93 Osteonecrosis, unspecified (Forearm)	0.399	0.601	0.000
M87.92 Osteonecrosis, unspecified (Upper arm)	0.399	0.601	0.000
M87.90 Osteonecrosis, unspecified (Multiple sites)	0.399	0.601	0.000
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.399	0.601	0.000
M66.34 Spontaneous rupture of flexor tendons (Hand)	0.398	0.602	0.000
M92.6 Juvenile osteochondrosis of tarsus	0.398	0.602	0.000
M94.07 Chondrocostal junction syndrome [Tietze]-Ankle/foot	0.397	0.603	0.000
M94.06 Chondrocostal junction syndrome [Tietze]-Lower leg	0.397	0.603	0.000
M94.05 Chondrocostal junction syndrome [Tietze]-Pelvic/thigh	0.397	0.603	0.000
M94.04 Chondrocostal junction syndrome [Tietze]-Hand	0.397	0.603	0.000
M94.03 Chondrocostal junction syndrome [Tietze]-Forearm	0.397	0.603	0.000
M94.02 Chondrocostal junction syndrome [Tietze]-Upper arm	0.397	0.603	0.000
M94.01 Chondrocostal junction syndrome [Tietze]-Shldr region	0.397	0.603	0.000
M94.00 Chondrocostal junction syndrome [Tietze]-Mult sites	0.397	0.603	0.000
M25.41 Effusion of joint (Shoulder region)	0.397	0.603	0.000
M66.4 Spontaneous rupture of other tendons	0.397	0.603	0.000
M91.2 Coxa plana	0.396	0.603	0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.396	0.604	0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.396	0.604	0.000
M22.3 Other derangements of patella	0.395	0.605	0.000
C82.6 Cutaneous follicle centre lymphoma	0.000	0.605	0.395
C82.5 Diffuse follicle centre lymphoma	0.000	0.605	0.395
C82.4 Follicular lymphoma grade IIIb	0.000	0.605	0.395
E23.7 Disorder of pituitary gland, unspecified	0.394	0.606	0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.000	0.606	0.394
E67.8 Other specified hyperalimentation	0.394	0.606	0.000
E67.3 Hypervitaminosis D	0.394	0.606	0.000
E67.2 Megavitamin-B6 syndrome	0.394	0.606	0.000
E67.1 Hypercarotenaemia	0.394	0.606	0.000
E67.0 Hypervitaminosis A	0.394	0.606	0.000
M60.08 Infective myositis (Other)	0.393	0.607	0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.393	0.607	0.000
M68.8 Other disorders of synovium and tendon in diseases classified elsewhere	0.392	0.608	0.000
M68.0 Synovitis and tenosynovitis in bacterial diseases classified elsewhere	0.392	0.608	0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]	0.000	0.608	0.392
M24.0 Loose body in joint	0.391	0.609	0.000
E03.8 Other specified hypothyroidism	0.391	0.609	0.000
M22.0 Recurrent dislocation of patella	0.391	0.609	0.000
M87.2 Osteonecrosis due to previous trauma	0.391	0.609	0.000
M25.44 Effusion of joint (Hand)	0.391	0.609	0.000
M19.02 Primary arthrosis of other joints (Upper arm)	0.390	0.610	0.000
M90.8 Osteopathy in other diseases classified elsewhere	0.389	0.610	0.000
M90.6 Osteitis deformans in neoplastic disease	0.389	0.610	0.000
M90.5 Osteonecrosis in other diseases classified elsewhere	0.389	0.610	0.000
M90.4 Osteonecrosis due to heamoglobinopathy	0.389	0.610	0.000
M90.3 Osteonecrosis in caisson disease	0.389	0.610	0.000
M90.2 Osteopathy in other infectious diseases classified elsewhere	0.389	0.610	0.000
M90.0 Tuberculosis of bone	0.389	0.610	0.000
M87.15 Osteonecrosis due to drugs (Pelvic region and thigh)	0.389	0.611	0.000
M95.2 Other acquired deformity of head	0.389	0.611	0.000
E20.9 Hypoparathyroidism, unspecified	0.389	0.611	0.000
M94.99 Disorder of cartilage, unspecified (Site unspecified)	0.389	0.611	0.000
M94.98 Disorder of cartilage, unspecified (Other)	0.389	0.611	0.000
M94.97 Disorder of cartilage, unspecified (Ankle and foot)	0.389	0.611	0.000
M94.95 Disorder of cartilage, unspecified (Pelvic region and thigh)	0.389	0.611	0.000
M94.94 Disorder of cartilage, unspecified (Hand)	0.389	0.611	0.000
M94.93 Disorder of cartilage, unspecified (Forearm)	0.389	0.611	0.000
M94.92 Disorder of cartilage, unspecified (Upper arm)	0.389	0.611	0.000
M94.91 Disorder of cartilage, unspecified (Shoulder region)	0.389	0.611	0.000
M94.90 Disorder of cartilage, unspecified (Multiple sites)	0.389	0.611	0.000
E23.6 Other disorders of pituitary gland	0.389	0.611	0.000
M87.91 Osteonecrosis, unspecified (Shoulder region)	0.388	0.611	0.000
E07.1 Dyshormogenetic goitre	0.388	0.612	0.000
E07.0 Hypersecretion of calcitonin	0.388	0.612	0.000
M19.06 Primary arthrosis of other joints-Lower leg	0.386	0.614	0.000
M21.59 Acquired clawhand, clubhand, clawfoot and clubfoot-Site uns	0.386	0.614	0.000
M21.58 Acquired clawhand, clubhand, clawfoot and clubfoot-Other	0.386	0.614	0.000
M21.56 Acquired clawhand, clubhand, clawfoot and clubfoot-Lower le	0.386	0.614	0.000
M21.55 Acquired clawhand, clubhand, clawfoot and clubfoot-Pelvic/t	0.386	0.614	0.000
M21.54 Acquired clawhand, clubhand, clawfoot and clubfoot (Hand)	0.386	0.614	0.000
M21.53 Acquired clawhand, clubhand, clawfoot and clubfoot-Forearm	0.386	0.614	0.000
M21.52 Acquired clawhand, clubhand, clawfoot and clubfoot-Upper ar	0.386	0.614	0.000
M21.51 Acquired clawhand, clubhand, clawfoot and clubfoot-Shldr re	0.386	0.614	0.000
M21.50 Acquired clawhand, clubhand, clawfoot and clubfoot (Multiple sites)	0.386	0.614	0.000
C91.0 Acute lymphoblastic leukaemia	0.000	0.615	0.384
M25.42 Effusion of joint (Upper arm)	0.383	0.617	0.000
C83.1 Small cleaved cell (diffuse)	0.000	0.617	0.383
M25.45 Effusion of joint (Pelvic region and thigh)	0.383	0.617	0.000
M02.3 Reiter's disease	0.382	0.618	0.000
M21.27 Flexion deformity (Ankle and foot)	0.381	0.619	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations